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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DRG1 Gene

protein-coding   GIFtS: 62
GCID: GC22P031795

Developmentally Regulated GTP Binding Protein 1

(Previous name: developmentally regulated GTP-binding protein 1)
(Previous symbol: NEDD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Developmentally Regulated GTP Binding Protein 11 2     DRG-12 3
NEDD31 2 3     NEDD-32 3
Developmentally Regulated GTP-Binding Protein 11 2     Developmentally-Regulated GTP-Binding Protein 12
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 32 3     Neural Precursor Cell Expressed, Developmentally Down-Regulated 32

External Ids:    HGNC: 30291   Entrez Gene: 47332   Ensembl: ENSG000001857217   OMIM: 6039525   UniProtKB: Q9Y2953   

Export aliases for DRG1 gene to outside databases

Previous GC identifers: GC22P028491 GC22P030120 GC22P014757


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DRG1 Gene: 
DRG1 (developmentally regulated GTP binding protein 1) is a protein-coding gene. Diseases associated with DRG1 include charcot-marie-tooth neuropathy type 4d, and charcot-marie-tooth neuropathy type 4. GO annotations related to this gene include GTP binding and transcription factor binding.

UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295
Function: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell
cycle arrest

Gene Wiki entry for DRG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DRG1 gene promoter:
         Pbx1a   Sp1   p53   FOXO3   POU3F2 (N-Oct-5b)   AP-4   XBP-1   Gfi-1   FOXO3b   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DRG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

DRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRG1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031795:  view genomic region     (about GC identifiers)

Start:
31,795,509 bp from pter      End:
31,924,726 bp from pter
Size:
129,218 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295 (See protein sequence)
Recommended Name: Developmentally-regulated GTP-binding protein 1  
Size: 367 amino acids; 40542 Da
Subunit: Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal
DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination.
Interacts with STK16; the interaction phosphorylates STK16 (By similarity)
Subcellular location: Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes
1 PDB 3D structure from and Proteopedia for DRG1:
2EKI (3D)    
Secondary accessions: B2RDS8 Q6FGP8 Q8WW69 Q9UGF2

Explore the universe of human proteins at neXtProt for DRG1: NX_Q9Y295

Explore proteomics data for DRG1 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated by UBE2I in response to MEKK1-mediated stimuli
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y295

  • DRG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DRG1 Protein Expression
    REFSEQ proteins: NP_004138.1  
    ENSEMBL proteins: 
     ENSP00000329715   ENSP00000408091   ENSP00000448252  

    Human Recombinant Protein Products for DRG1: 
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    Novus Biologicals DRG1 Proteins
    Novus Biologicals DRG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DRG1
    Cloud-Clone Corp. Proteins for DRG1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005844polysome IDA19819225
    GO:0016021integral to membrane ----
    GO:0045111intermediate filament cytoskeleton IDA--

    DRG1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DRG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR027417 P-loop_NTPase
     IPR005225 Small_GTP-bd_dom
     IPR012676 TGS-like
     IPR006073 GTP_binding_domain
     IPR004095 TGS

    Graphical View of Domain Structure for InterPro Entry Q9Y295

    ProtoNet protein and cluster: Q9Y295

    2 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature


    UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295
    Similarity: Belongs to the GTP1/OBG family
    Similarity: Contains 1 G (guanine nucleotide-binding) domain


    DRG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRG1_HUMAN, Q9Y295
    Function: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell
    cycle arrest
    Induction: By androgens

         Genatlas biochemistry entry for DRG1:
    developmentally regulated GTP-binding protein 1,mouse Nedd3 homolog,binding to SCL in clones from human fetal
    liver and thymus

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
    GO:0008134transcription factor binding TAS9824680
    GO:0015093ferrous iron transmembrane transporter activity ----
    GO:0042802identical protein binding IPI--
         
    DRG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Drg1 (no phenotypes)

    DRG1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DRG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DRG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRG1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DRG1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DRG1:
    hsa-miR-640 hsa-miR-145 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidDRG1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DRG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/866 Interacting proteins for DRG1 (Q9Y2951, 2, 3 ENSP000003297154) via UniProtKB, MINT, STRING, and/or I2D (see all 866)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent TAS9824680
    GO:0007275multicellular organismal development TAS1280421
    GO:0015684ferrous iron transport ----

    DRG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DRG1

    1 HMDB Compound for DRG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about DRG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DRG1 gene: 
    NM_004147.3  

    Unigene Cluster for DRG1:

    Developmentally regulated GTP binding protein 1
    Hs.115242  [show with all ESTs]
    Unigene Representative Sequence: AF078103
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331457(uc003aku.3) ENST00000416465 ENST00000433341 ENST00000486584
    ENST00000469673 ENST00000548143
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DRG1:
    hsa-miR-640 hsa-miR-145 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidDRG1 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRG1

    Additional mRNA sequence: 

    AF078103.1 AJ005940.1 AK098576.1 AK315659.1 AL133085.1 BC019285.1 BC020803.1 BT007237.1 
    CR456488.1 CR542059.1 

    17 DOTS entries:

    DT.75100551  DT.456234  DT.120664422  DT.91761126  DT.120965055  DT.91761122  DT.100884254  DT.120664224 
    DT.97864258  DT.95332803  DT.100884252  DT.120664288  DT.120664431  DT.91761127  DT.95332807  DT.95332809 
    DT.120664256 

    24/381 AceView cDNA sequences (see all 381):

    CR625851 AI521976 CR542059 AV710811 BM724058 BM785587 BX443052 BM828844 
    BM662390 AA584332 BU552960 AI567315 BU506861 CR617097 CB133279 AA488336 
    BM475939 BQ932405 CR617637 AA313577 CB133755 BQ183681 CB139639 AA314769 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DRG1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                                      -                                       
    SP2:                                                                              
    SP3:                    -                 -                                       


    ECgene alternative splicing isoforms for DRG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DRG1 expression in normal human tissues (normalized intensities)      DRG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAAGCACC
    DRG1 Expression
    About this image


    DRG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             brain/midbrain   
     
     Kidney (Urinary System)
             Metanephros
     
     Uterus (Reproductive System)
             CERVIX   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Neural Tube (Nervous System)
             Telencephalon

    See DRG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DRG1

    SOURCE GeneReport for Unigene cluster: Hs.115242

    UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295
    Tissue specificity: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and
    brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DRG1 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drg11 , 5 developmentally regulated GTP binding protein 11, 5 91.83(n)1
    99.73(a)1
      11 (2.23 cM)5
    134941  NM_007879.11  NP_031905.11 
     31873605 
    chicken
    (Gallus gallus)
    Aves DRG11 developmentally regulated GTP binding protein 1 81.47(n)
    98.64(a)
      416962  NM_001032362.1  NP_001027533.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.922 Xenopus laevis Xdrg mRNA for GTP-binding protein DRG, more 79.95(n)    D13865.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb06g122 wufb06g12 78.54(n)   336823  BC053264.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 128up1 , 3 GTP binding3
    upstream of RpIII1281
    80(a)3
    70.75(n)1
    80.93(a)1
      2 48D83
    362881  NM_080485.51  NP_536733.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T28D6.61 Protein T28D6.6 67.03(n)
    81.32(a)
      176563  NM_067056.5  NP_499457.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RBG1(YAL036C)4
    RBG11
    Member of the DRG family of GTP-binding proteins; associates more4
    Rbg1p1
    63.03(n)1
    65.94(a)1
      1(76152-75043)4
    8511951, 4  NP_009364.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G395201 GTP-binding protein-relatedlike protein 65.67(n)
    70.57(a)
      830106  NM_120112.3  NP_195662.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109182 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.17(n)    AK066361.1 


    ENSEMBL Gene Tree for DRG1 (if available)
    TreeFam Gene Tree for DRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DRG1 gene
    2 SIMAP similar genes for DRG1 using alignment to 3 protein entries:     DRG1_HUMAN (see all proteins):
    DKFZp434N1827    DRG2

    DRG1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DRG1
    PGOHUM00000239985 PGOHUM00000237732


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/722 SNPs in DRG1 are shown (see all 722)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386327521,2
    C--31793675(+) TCGATC/TTCCTG 1 -- us2k10--------
    rs1921477731,2
    --31793742(+) GCCACC/TGCGCC 1 -- us2k10--------
    rs1836585541,2
    --31793793(+) ACTCTC/TTACTC 1 -- us2k10--------
    rs1428616691,2
    --31793797(+) TCTACG/TCTGTC 1 -- us2k10--------
    rs1470139481,2
    --31793853(+) AACGAC/TTGCAT 1 -- us2k10--------
    rs1382152901,2
    C--31794419(+) CAGCC-/CTGTGGGTTAA
    GCCTGGCCTGTCGA
    CTGTG
    1 -- us2k10--------
    rs1892024751,2
    --31794547(+) AGTTCA/CTGGAC 1 -- us2k10--------
    rs622361861,2
    C,F--31794592(+) GTCTTC/TTGAAA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs113314471,2
    C--31794715(+) CACAGT/-TAAGA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1447282901,2
    --31794734(+) TGTATA/TTTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DRG1 (31795509 - 31924726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DRG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1490942CNV Deletion17803354
    esv2656791CNV Deletion23128226
    nsv834176CNV Loss17160897
    nsv483006CNV Gain15286789

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603952    OMIM disorders: --

    7 diseases for DRG1:    About MalaCards
    charcot-marie-tooth neuropathy type 4d    charcot-marie-tooth neuropathy type 4    autism spectrum disorder    tuberculosis
    prostate cancer    prostatitis    breast cancer


    DRG1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DRG1
    Human Genome Epidemiology (HuGE) Navigator: DRG1 (8 documents)

    Export disorders for DRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DRG1 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with DRG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DRG represents a family of two closely related GTP-binding proteins. (PubMed id 10760581)1, 2, 9 Li B. and Trueeb B. (2000)
    2. Independent stabilizations of polysomal Drg1/Dfrp1 co mplex and non-polysomal Drg2/Dfrp2 complex in mammalian cells. (PubMed id 19819225)1, 2 Ishikawa K....Inoue J. (2009)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    4. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (2007)
    5. Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2. (PubMed id 15676025)1, 2 Ishikawa K.... Inoue J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    9. SCL binds the human homologue of DRG in vivo. (PubMed id 9824680)1, 2 Zhao X.-F. and Aplan P.D. (1998)
    10. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. (PubMed id 7929244)1, 3 Schenker T....Trueb B. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4733 HGNC: 3029 AceView: DRG1 Ensembl:ENSG00000185721 euGenes: HUgn4733
    ECgene: DRG1 H-InvDB: DRG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DRG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DRG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DRG1 gene:
    Search GeneIP for patents involving DRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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