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Aliases for DRG1 Gene

Aliases for DRG1 Gene

  • Developmentally Regulated GTP Binding Protein 1 2 3
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 3 3 4
  • Developmentally Regulated GTP-Binding Protein 1 2 3
  • NEDD-3 3 4
  • DRG-1 3 4
  • NEDD3 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 3 3
  • Developmentally-Regulated GTP-Binding Protein 1 3

External Ids for DRG1 Gene

Previous HGNC Symbols for DRG1 Gene

  • NEDD3

Previous GeneCards Identifiers for DRG1 Gene

  • GC22P028491
  • GC22P030120
  • GC22P031795
  • GC22P014757

Summaries for DRG1 Gene

GeneCards Summary for DRG1 Gene

DRG1 (Developmentally Regulated GTP Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and transcription factor binding.

UniProtKB/Swiss-Prot for DRG1 Gene

  • Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest

Gene Wiki entry for DRG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRG1 Gene

Genomics for DRG1 Gene

Regulatory Elements for DRG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DRG1 Gene

31,399,523 bp from pter
31,528,740 bp from pter
129,218 bases
Plus strand

Genomic View for DRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRG1 Gene

Proteins for DRG1 Gene

  • Protein details for DRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Developmentally-regulated GTP-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RDS8
    • Q6FGP8
    • Q8WW69
    • Q9UGF2

    Protein attributes for DRG1 Gene

    367 amino acids
    Molecular mass:
    40542 Da
    Quaternary structure:
    • Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DRG1 Gene

neXtProt entry for DRG1 Gene

Proteomics data for DRG1 Gene at MOPED

Post-translational modifications for DRG1 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Ubiquitination at Lys46, Lys61, Lys112, Lys126, Lys159, Lys186, Lys213, and Lys290
  • Modification sites at PhosphoSitePlus

Other Protein References for DRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DRG1 Gene

Domains for DRG1 Gene

Suggested Antigen Peptide Sequences for DRG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y295
  • Contains 1 OBG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with DRG1: view

No data available for Gene Families for DRG1 Gene

Function for DRG1 Gene

Molecular function for DRG1 Gene

GENATLAS Biochemistry:
developmentally regulated GTP-binding protein 1,mouse Nedd3 homolog,binding to SCL in clones from human fetal liver and thymus
UniProtKB/Swiss-Prot Function:
Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest
UniProtKB/Swiss-Prot Induction:
By androgens

Gene Ontology (GO) - Molecular Function for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
GO:0008134 transcription factor binding TAS 9824680
GO:0015093 ferrous iron transmembrane transporter activity --
GO:0042802 identical protein binding IPI 23711155
genes like me logo Genes that share ontologies with DRG1: view

Animal Model Products

miRNA for DRG1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DRG1 Gene

Localization for DRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRG1 Gene

Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.

Subcellular locations from

Jensen Localization Image for DRG1 Gene COMPARTMENTS Subcellular localization image for DRG1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IDA 19819225
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with DRG1: view

Pathways for DRG1 Gene

SuperPathways for DRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 9824680
GO:0007275 multicellular organismal development TAS 1280421
GO:0015684 ferrous iron transport --
genes like me logo Genes that share ontologies with DRG1: view

No data available for Pathways by source for DRG1 Gene

Compounds for DRG1 Gene

(1) HMDB Compounds for DRG1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with DRG1: view

Transcripts for DRG1 Gene

Unigene Clusters for DRG1 Gene

Developmentally regulated GTP binding protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: -
SP3: - -

Relevant External Links for DRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRG1 Gene

mRNA expression in normal human tissues for DRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRG1 Gene

This gene is overexpressed in Testis (4.1).

Protein differential expression in normal tissues for DRG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.1) and Breast (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DRG1 Gene

SOURCE GeneReport for Unigene cluster for DRG1 Gene Hs.115242

mRNA Expression by UniProt/SwissProt for DRG1 Gene

Tissue specificity: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
genes like me logo Genes that share expressions with DRG1: view

Expression partners for DRG1 Gene

In Situ Assay Products

Orthologs for DRG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DRG1 35
  • 94.37 (n)
  • 100 (a)
-- 36
  • 97 (a)
DRG1 36
  • 100 (a)
(Canis familiaris)
Mammalia DRG1 35
  • 94.55 (n)
  • 100 (a)
DRG1 36
  • 100 (a)
(Mus musculus)
Mammalia Drg1 35
  • 91.83 (n)
  • 99.73 (a)
Drg1 16
Drg1 36
  • 100 (a)
(Pan troglodytes)
Mammalia DRG1 35
  • 99.73 (n)
  • 100 (a)
DRG1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Drg1 35
  • 91.73 (n)
  • 99.73 (a)
(Monodelphis domestica)
Mammalia DRG1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia DRG1 36
  • 99 (a)
(Gallus gallus)
Aves DRG1 35
  • 81.47 (n)
  • 98.64 (a)
DRG1 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia drg1 35
  • 79.2 (n)
  • 95.37 (a)
Str.2997 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.92 35
(Danio rerio)
Actinopterygii drg1 35
  • 77.53 (n)
  • 92.88 (a)
wufb06g12 35
drg1 36
  • 92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.102 35
fruit fly
(Drosophila melanogaster)
Insecta 128up 37
  • 80 (a)
128up 35
  • 70.75 (n)
  • 80.93 (a)
128up 36
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010624 35
  • 69.49 (n)
  • 80.87 (a)
(Caenorhabditis elegans)
Secernentea T28D6.6 35
  • 66.3 (n)
  • 80.22 (a)
T28D6.6 36
  • 81 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR372C 35
  • 61.67 (n)
  • 66.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23287g 35
  • 63.22 (n)
  • 65.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBG1 35
  • 62.58 (n)
  • 65.12 (a)
RBG1 36
  • 65 (a)
RBG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39520 35
  • 64.85 (n)
  • 69.48 (a)
(Glycine max)
eudicotyledons Gma.4107 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4893 35
(Hordeum vulgare)
Liliopsida Hv.1866 35
(Oryza sativa)
Liliopsida Os.10918 35
Os07g0627800 35
  • 66.76 (n)
  • 71.93 (a)
(Triticum aestivum)
Liliopsida Ta.7400 35
(Zea mays)
Liliopsida Zm.6218 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.256 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00389 35
  • 61.19 (n)
  • 66.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC9.07c 35
  • 60.84 (n)
  • 65.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9185 36
  • 81 (a)
Species with no ortholog for DRG1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DRG1 Gene

Gene Tree for DRG1 (if available)
Gene Tree for DRG1 (if available)

Paralogs for DRG1 Gene

Selected SIMAP similar genes for DRG1 Gene using alignment to 3 proteins: Pseudogenes for DRG1 Gene

genes like me logo Genes that share paralogs with DRG1: view

No data available for Paralogs for DRG1 Gene

Variants for DRG1 Gene

Sequence variations from dbSNP and Humsavar for DRG1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs695257 -- 31,427,844(+) ttctc(C/T)tgcct intron-variant
rs695269 -- 31,401,829(+) tgggc(A/G)gatca intron-variant
rs695304 -- 31,405,680(+) GTGTG(G/T)GGGGG intron-variant
rs695334 -- 31,433,624(+) AGGCT(C/G)TTTAT intron-variant
rs695413 -- 31,413,380(+) tgagc(C/T)gctgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRG1 Gene

Variant ID Type Subtype PubMed ID
nsv834176 CNV Loss 17160897
nsv483006 CNV Gain 15286789
esv2656791 CNV Deletion 23128226
esv1490942 CNV Deletion 17803354

Relevant External Links for DRG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRG1 Gene

Disorders for DRG1 Gene

Relevant External Links for DRG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DRG1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DRG1 Gene

Publications for DRG1 Gene

  1. DRG represents a family of two closely related GTP-binding proteins. (PMID: 10760581) Li B. … Trueeb B. (Biochim. Biophys. Acta 2000) 3 4 23
  2. DRG: a novel developmentally regulated GTP-binding protein. (PMID: 1449490) Sazuka T. … Kumar S. (Biochem. Biophys. Res. Commun. 1992) 2 3
  3. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. (PMID: 7929244) Schenker T. … Trueb B. (J. Biol. Chem. 1994) 2 3
  4. SCL binds the human homologue of DRG in vivo. (PMID: 9824680) Zhao X.-F. … Aplan P.D. (Biochim. Biophys. Acta 1998) 3 4
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for DRG1 Gene

Sources for DRG1 Gene

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