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DRG1 Gene

protein-coding   GIFtS: 63
GCID: GC22P031795

Developmentally Regulated GTP Binding Protein 1

(Previous name: developmentally regulated GTP-binding protein 1)
(Previous symbol: NEDD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Developmentally Regulated GTP Binding Protein 11 2     DRG-12 3
NEDD31 2 3     NEDD-32 3
Developmentally Regulated GTP-Binding Protein 11 2     Developmentally-Regulated GTP-Binding Protein 12
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 32 3     Neural Precursor Cell Expressed, Developmentally Down-Regulated 32

External Ids:    HGNC: 30291   Entrez Gene: 47332   Ensembl: ENSG000001857217   OMIM: 6039525   UniProtKB: Q9Y2953   

Export aliases for DRG1 gene to outside databases

Previous GC identifers: GC22P028491 GC22P030120 GC22P014757


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DRG1 Gene:
DRG1 (developmentally regulated GTP binding protein 1) is a protein-coding gene. Diseases associated with DRG1 include charcot-marie-tooth neuropathy type 4d, and charcot-marie-tooth neuropathy type 4. GO annotations related to this gene include transcription factor binding and identical protein binding.

UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295
Function: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell
cycle arrest

Gene Wiki entry for DRG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DRG1 gene promoter:
         Pbx1a   Sp1   p53   FOXO3   POU3F2 (N-Oct-5b)   AP-4   XBP-1   Gfi-1   FOXO3b   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRG1 promoter sequence
   Search Chromatin IP Primers for DRG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

DRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRG1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031795:  view genomic region     (about GC identifiers)

Start:
31,795,509 bp from pter      End:
31,924,726 bp from pter
Size:
129,218 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295 (See protein sequence)
Recommended Name: Developmentally-regulated GTP-binding protein 1  
Size: 367 amino acids; 40542 Da
Subunit: Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal
DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination.
Interacts with STK16; the interaction phosphorylates STK16 (By similarity)
1 PDB 3D structure from and Proteopedia for DRG1:
2EKI (3D)    
Secondary accessions: B2RDS8 Q6FGP8 Q8WW69 Q9UGF2

Explore the universe of human proteins at neXtProt for DRG1: NX_Q9Y295

Explore proteomics data for DRG1 at MOPED

Post-translational modifications: 

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli1
  • Ubiquitination2 at Lys46, Lys61, Lys112, Lys126, Lys159, Lys186, Lys213, Lys290
  • Modification sites at PhosphoSitePlus

  • See DRG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004138.1  
    ENSEMBL proteins: 
     ENSP00000329715   ENSP00000408091   ENSP00000448252  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR027417 P-loop_NTPase
     IPR005225 Small_GTP-bd_dom
     IPR012676 TGS-like
     IPR006073 GTP_binding_domain
     IPR004095 TGS

    Graphical View of Domain Structure for InterPro Entry Q9Y295

    ProtoNet protein and cluster: Q9Y295

    2 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature


    UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295
    Similarity: Belongs to the GTP1/OBG family
    Similarity: Contains 1 G (guanine nucleotide-binding) domain


    DRG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRG1_HUMAN, Q9Y295
    Function: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell
    cycle arrest
    Induction: By androgens

         Genatlas biochemistry entry for DRG1:
    developmentally regulated GTP-binding protein 1,mouse Nedd3 homolog,binding to SCL in clones from human fetal
    liver and thymus

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
    GO:0008134transcription factor binding TAS9824680
    GO:0015093ferrous iron transmembrane transporter activity ----
    GO:0042802identical protein binding IPI--
         
    DRG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Drg1 (no phenotypes)

    DRG1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRG1

    miRNA
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    miRTarBase miRNAs that target DRG1:
    hsa-mir-615-3p (MIRT040302), hsa-mir-605-5p (MIRT040480), hsa-mir-455-5p (MIRT040743), hsa-mir-34a-5p (MIRT025534)

    Block miRNA regulation of human, mouse, rat DRG1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DRG1:
    hsa-miR-640 hsa-miR-145 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidDRG1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DRG1

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    GenScript: all cDNA clones in your preferred vector: DRG1 (NM_004147)
    Sino Biological Human cDNA Clone for DRG1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRG1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRG1_HUMAN, Q9Y295: Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    cytosol3
    lysosome1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IDA19819225
    GO:0016021integral component of membrane ----
    GO:0045111intermediate filament cytoskeleton ----

    DRG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DRG1
    Interactions:

        Search GeneGlobe Interaction Network for DRG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DRG1 (Q9Y2951, 2, 3 ENSP000003297154) via UniProtKB, MINT, STRING, and/or I2D (see all 888)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated TAS9824680
    GO:0007275multicellular organismal development TAS1280421
    GO:0015684ferrous iron transport ----

    DRG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DRG1

    1 HMDB Compound for DRG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DRG1 gene: 
    NM_004147.3  

    Unigene Cluster for DRG1:

    Developmentally regulated GTP binding protein 1
    Hs.115242  [show with all ESTs]
    Unigene Representative Sequence: AF078103
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331457(uc003aku.3) ENST00000416465 ENST00000433341 ENST00000486584
    ENST00000469673 ENST00000548143
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate DRG1:
    hsa-miR-640 hsa-miR-145 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidDRG1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DRG1
    Predesigned siRNA for gene silencing in human, mouse, rat DRG1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRG1
    Primer
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    OriGene qPCR primer pairs and template standards for DRG1
    OriGene qSTAR qPCR primer pairs in human, mouse for DRG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRG1
      QuantiTect SYBR Green Assays in human, mouse, rat DRG1
      QuantiFast Probe-based Assays in human, mouse, rat DRG1

    Additional mRNA sequence: 

    AF078103.1 AJ005940.1 AK098576.1 AK315659.1 AL133085.1 BC019285.1 BC020803.1 BT007237.1 
    CR456488.1 CR542059.1 

    17 DOTS entries:

    DT.75100551  DT.456234  DT.120664422  DT.91761126  DT.120965055  DT.91761122  DT.100884254  DT.120664224 
    DT.97864258  DT.95332803  DT.100884252  DT.120664288  DT.120664431  DT.91761127  DT.95332807  DT.95332809 
    DT.120664256 

    Selected AceView cDNA sequences (see all 381):

    BQ932405 CB133279 BP369259 NM_004147 CR598092 BQ959637 AI421012 AV710811 
    CR610738 CR456488 CR617637 AA584332 CR617097 BI752260 BQ183681 BP371454 
    BF242842 AA877656 BX367508 CR625851 BQ926384 AA488336 AA313577 BM828844 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DRG1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                                      -                                       
    SP2:                                                                              
    SP3:                    -                 -                                       


    ECgene alternative splicing isoforms for DRG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DRG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAAGCACC
    DRG1 Expression
    About this image


    DRG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    DRG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115242

    UniProtKB/Swiss-Prot: DRG1_HUMAN, Q9Y295
    Tissue specificity: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and
    brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DRG1 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drg11 , 5 developmentally regulated GTP binding protein 11, 5 91.83(n)1
    99.73(a)1
      11 (2.23 cM)5
    134941  NM_007879.11  NP_031905.11 
     31873605 
    chicken
    (Gallus gallus)
    Aves DRG11 developmentally regulated GTP binding protein 1 81.47(n)
    98.64(a)
      416962  NM_001032362.1  NP_001027533.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.922 Xenopus laevis Xdrg mRNA for GTP-binding protein DRG, more 79.95(n)    D13865.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb06g122 wufb06g12 78.54(n)   336823  BC053264.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 128up1 , 3 GTP binding3
    upstream of RpIII1281
    80(a)3
    70.75(n)1
    80.93(a)1
      2 48D83
    362881  NM_080485.51  NP_536733.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T28D6.61 T28D6.6 66.3(n)
    80.22(a)
      176563  NM_001268197.1  NP_001255126.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RBG1(YAL036C)4
    RBG11
    Member of the DRG family of GTP-binding proteins; associates more4
    RBG11
    62.58(n)1
    65.12(a)1
      1(76152-75043)4
    8511951, 4  NP_009364.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G395201 AT4G39520 64.85(n)
    69.48(a)
      830106  NM_120112.3  NP_195662.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109182 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.17(n)    AK066361.1 


    ENSEMBL Gene Tree for DRG1 (if available)
    TreeFam Gene Tree for DRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRG1 gene
    2 SIMAP similar genes for DRG1 using alignment to 3 protein entries:     DRG1_HUMAN (see all proteins):
    DKFZp434N1827    DRG2

    DRG1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DRG1
    PGOHUM00000239985 PGOHUM00000237732


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DRG1 (see all 722)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386327521,2
    C--31793675(+) TCGATC/TTCCTG 1 -- us2k10--------
    rs1921477731,2
    --31793742(+) GCCACC/TGCGCC 1 -- us2k10--------
    rs1836585541,2
    --31793793(+) ACTCTC/TTACTC 1 -- us2k10--------
    rs1428616691,2
    --31793797(+) TCTACG/TCTGTC 1 -- us2k10--------
    rs1470139481,2
    --31793853(+) AACGAC/TTGCAT 1 -- us2k10--------
    rs1382152901,2
    C--31794419(+) CAGCC-/CTGTGGGTTAA
    GCCTGGCCTGTCGA
    CTGTG
    1 -- us2k10--------
    rs1892024751,2
    --31794547(+) AGTTCA/CTGGAC 1 -- us2k10--------
    rs622361861,2
    C,F--31794592(+) GTCTTC/TTGAAA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs113314471,2
    C--31794715(+) CACAGT/-TAAGA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1447282901,2
    --31794734(+) TGTATA/TTTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DRG1 (31795509 - 31924726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DRG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1490942CNV Deletion17803354
    esv2656791CNV Deletion23128226
    nsv834176CNV Loss17160897
    nsv483006CNV Gain15286789

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603952    OMIM disorders: --

    11 diseases for DRG1:    
    About MalaCards
    charcot-marie-tooth neuropathy type 4d    charcot-marie-tooth neuropathy type 4    autism spectrum disorder    neuropathy
    tuberculosis    neuroblastoma    prostate cancer    prostatitis
    breast cancer    malaria    cerebritis


    DRG1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DRG1
    Human Genome Epidemiology (HuGE) Navigator: DRG1 (8 documents)

    Export disorders for DRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRG1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with DRG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DRG represents a family of two closely related GTP-binding proteins. (PubMed id 10760581)1, 2, 9 Li B. and Trueeb B. (Biochim. Biophys. Acta 2000)
    2. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non- polysomal Drg2/Dfrp2 complex in mammalian cells. (PubMed id 19819225)1, 2 Ishikawa K.... Inoue J. (Biochem. Biophys. Res. Commun. 2009)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    4. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (Nucleic Acids Res. 2007)
    5. Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2. (PubMed id 15676025)1, 2 Ishikawa K.... Inoue J. (Genes Cells 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. SCL binds the human homologue of DRG in vivo. (PubMed id 9824680)1, 2 Zhao X.-F. and Aplan P.D. (Biochim. Biophys. Acta 1998)
    10. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. (PubMed id 7929244)1, 3 Schenker T.... Trueb B. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4733 HGNC: 3029 AceView: DRG1 Ensembl:ENSG00000185721 euGenes: HUgn4733
    ECgene: DRG1 H-InvDB: DRG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DRG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DRG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRG1 gene:
    Search GeneIP for patents involving DRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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