Aliases for DRD5 Gene
External Ids for DRD5 Gene
Previous Symbols for DRD5 Gene
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD5 Gene
DRD5 (Dopamine Receptor D5) is a Protein Coding gene. Diseases associated with DRD5 include substance dependence and blepharospasm. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include dopamine binding and dopamine neurotransmitter receptor activity, coupled via Gs. An important paralog of this gene is TAAR9.
UniProtKB/Swiss-Prot for DRD5 Gene
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1 receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution (mainly limbic areas).