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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DRD5 Gene

protein-coding   GIFtS: 65
GCID: GC04P009783

dopamine receptor D5


(Previous symbol: DRD1L2)
 Explore 35 diseases affiliated with
DRD5 via our new
 Human Malady Compendium 
Biological research products
for DRD5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dopamine Receptor D51 2     D1beta Dopamine Receptor2 3
DRD1B1 2 3 5     DBDR2
DRD1L21 2 3 5     D(1B) Dopamine Receptor2
D(5) Dopamine Receptor2 3     Dopamine Receptor D1B2
Dopamine D5 Receptor2 3     

External Ids:    HGNC: 30261   Entrez Gene: 18162   Ensembl: ENSG000001696767   OMIM: 1264535   UniProtKB: P219183   

Export aliases for DRD5 gene to outside databases

Previous GC identifers: GC04P009453 GC04M009734 GC04P009534 GC04P009459 GC04P009392 GC04P009117


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DRD5:
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which
stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a
10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and
2. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

summary for DRD5:
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor
G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly
homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1
receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution
(mainly limbic areas).

Gene Wiki entry for DRD5 (Dopamine receptor D5)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DRD5 gene promoter:
         RORalpha1   PPAR-gamma1   Sp1   PPAR-gamma2   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DRD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

DRD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRD5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P009783:  view genomic region     (about GC identifiers)

Start:
9,783,258 bp from pter      End:
9,785,633 bp from pter
Size:
2,376 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918 (See protein sequence)
Recommended Name: D(1B) dopamine receptor  
Size: 477 amino acids; 52951 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2R9S3 Q8NEQ8

Explore the universe of human proteins at neXtProt for DRD5: NX_P21918

DRD5 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_000789.1  
ENSEMBL proteins: 
 ENSP00000306129  
Reactome Protein details: P21918
Human Recombinant Protein Products: 
EMD Millipore Purified and/or Recombinant DRD5 Protein
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OriGene Protein Over-expression Lysate: DRD5
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Novus Biologicals DRD5 Protein
Novus Biologicals DRD5 Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for DRD5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS9457173
GO:0031526brush border membrane IEA--


DRD5 for ontologies           About GeneDecksing



DRD5 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of DRD5
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OriGene Custom Antibody Services for DRD5 
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Novus Biologicals DRD5 Antibodies
Search for Antibodies for DRD5 at Abcam  
Uscn Antibodies for DRD5
ThermoFisher Antibodies for DRD5

Assay Products for DRD5: 
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OriGene Custom Immunoassay Development
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GenScript DRD5-overexpressing Cell Line for Assay
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for DRD5


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DRD5 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000497 Dopa_1B_rcpt
 IPR000929 Dopamine_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P21918

ProtoNet protein and cluster: P21918

2 Blocks protein families:
IPB000497 Dopamine 1B receptor signature
IPB000929 Dopamine receptor signature


UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Similarity: Belongs to the G-protein coupled receptor 1 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

     Genatlas biochemistry entry for DRD5:
dopamine receptor D5,high affinity,adenylate cyclase stimulating,G protein coupled receptor superfamily,complexing with
GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions between
these receptor systems

miRNA
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DRD5
1 QIAGEN miScript miRNA Assays for microRNA that regulate DRD5:
hsa-miR-942
SwitchGear 3'UTR luciferase reporter plasmidDRD5 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DRD5 (see all 7)
OriGene shRNA RFP: DRD5
OriGene siRNA: DRD5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DRD5

Gene Editing
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Clone
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EMD Millipore Clones for the Expression of DRD5
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: DRD5 (NM_000798)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRD5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD5 

Cell Line
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Search LifeMap BioReagents cell lines for DRD5

In Situ Assay
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DRD5

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs TAS9457173
GO:0001965G-protein alpha-subunit binding ----
GO:0004952dopamine neurotransmitter receptor activity IDA1826762
GO:0008144drug binding ----
GO:0035240dopamine binding IDA1826762


DRD5 for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for DRD5:
 Decreased substrate adherent c  Increased gamma-H2AX phosphory 

Animal Models:
     Mouse knock-out Drd5tm1Sib for DRD5
     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Drd5):
 cardiovascular system  endocrine/exocrine gland  nervous system  normal  renal/urinary system 
 vision/eye 

DRD5 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)1.00
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.75
Neuroactive ligand-receptor interaction0.38
2Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
GPCR downstream signaling0.89
3Development_Ligand-independent activation of ESR1 and ESR2
Development_Ligand-independent activation of ESR1 and ESR21.00
Development Ligand-independent activation of ESR1 and ESR20.97
4Transcription CREB pathway
Transcription CREB pathway1.00
Transcription_CREB pathway0.93
5Monoamine GPCRs
Monoamine GPCRs1.00
Amine ligand-binding receptors0.79

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DRD5
    Transcription CREB pathway
Development Ligand-independent activation of ESR1 and ESR2

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DRD5
    CDK5 Pathway
Dopamine-DARPP32 Feedback onto cAMP Pathway

2 GeneGo (Thomson Reuters) Pathways for DRD5
    Development Ligand-independent activation of ESR1 and ESR2
Transcription CREB pathway

2 BioSystems Pathways for DRD5 
    GPCRs, Class A Rhodopsin-like
Monoamine GPCRs

5/8        Reactome Pathways for DRD5 (see all 8)
    GPCR downstream signaling
Signaling by GPCR
GPCR ligand binding
Class A/1 (Rhodopsin-like receptors)
Dopamine receptors


2         Kegg Pathways  (Kegg details for DRD5):
    Calcium signaling pathway
Neuroactive ligand-receptor interaction


DRD5 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DRD5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/73 Interacting proteins for DRD5 (P219183 ENSP000003061294) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
InteractantInteraction Details
GeneCardExternal ID(s)
GABRG2P185073, ENSP000004107324I2D: score=1 STRING: ENSP00000410732
GNA12Q031133, ENSP000002753644I2D: score=2 STRING: ENSP00000275364
GNA13Q143443, ENSP000004007174I2D: score=2 STRING: ENSP00000400717
GNAZP190863, ENSP000002489964I2D: score=1 STRING: ENSP00000248996
NCS1P621663, ENSP000003614754I2D: score=2 STRING: ENSP00000361475
About this table

Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001963synaptic transmission, dopaminergic NAS11036203
GO:0001975response to amphetamine IEA--
GO:0001992regulation of systemic arterial blood pressure by vasopressin IEA--
GO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA--
GO:0006469negative regulation of protein kinase activity ----


DRD5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DRD5 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for DRD5 available from Tocris Bioscience    About this table
CompoundAction CAS #
Dihydrexidine hydrochlorideSelective D1-like agonist[123039-93-0]
SCH 39166 hydrobromideHigh affinity D1/D5 receptor antagonist--
SCH 23390 hydrochlorideStandard selective D1-like antagonist. Also 5-HT2C agonist[125941-87-9]

1 HMDB Compound for DRD5    About this table
CompoundSynonyms CAS #PubMed Ids
Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

10/18 DrugBank Compounds for DRD5 (see all 18)    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
FenoldopamFenodopam mesylate (see all 3)67227-57-0targetagonist17139284 19293728 8103596 17016423
CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist11436517 18691132 16982285
CarphenazineCarfenazine (see all 2)2622-30-2targetantagonist4861216 4887393 4889058
Levodopa3,4-dihydroxyphenylalanine (see all 4)59-92-7targetagonist11978145 18549347 9633680
ApomorphineApomorfin (see all 9)41372-20-7targetagonist11752352 18691132
Olanzapine-- 132539-06-1targetantagonist10227113 17848919
Zuclopenthixolzuclopenthixol acetate (see all 5)53772-83-1targetantagonist1822319 10222441
AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist partial agonist17848919
BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist18691132
DopamineDopamin (see all 6)51-61-6targetagonist17301410

7 Novoseek chemical compound relationships for DRD5 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dopamine 78.6 69 10337922 (3), 10578238 (2), 11036203 (2), 14699430 (2) (see all 44)
methylphenidate 47.8 2 10889550 (1), 15108184 (1)
catecholamine 26.9 1 8522958 (1)
clozapine 20.9 1 16395606 (1)
tyrosine 0 3 16459247 (1), 11449400 (1)
cyclic amp 0 2 7609904 (1)
norepinephrine 0 1 18480676 (1)

Search CenterWatch for drugs/clinical trials and news about DRD5 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DRD5 gene: 
NM_000798.4  

Unigene Cluster for DRD5:

Dopamine receptor D5
Hs.380681  [show with all ESTs]
Unigene Representative Sequence: NM_000798
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000304374(uc003gmb.4)

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DRD5
1 QIAGEN miScript miRNA Assays for microRNA that regulate DRD5:
hsa-miR-942
SwitchGear 3'UTR luciferase reporter plasmidDRD5 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DRD5 (see all 7)
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DRD5
Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: DRD5 (NM_000798)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD5 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRD5
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRD5

Additional cDNA sequence: 

AK313897.1 AY136750.1 BC009748.2 

1 DOTS entry:

DT.97775741 

13 AceView cDNA sequences:

BX283486 CN831342 BE746231 NM_000798 BC009748 AY136750 CD609573 BM805454 
BV200290 BV200289 CN831353 BM718235 BQ186987 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DRD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTCTGTG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See DRD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DRD5

SOURCE GeneReport for Unigene cluster: Hs.380681

UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Tissue specificity: Neuron-specific, localized primarily within limbic regions of the brain

    SABiosciences Expression via Pathway-Focused PCR Arrays including DRD5: 
          Neurotransmitter Receptors in human mouse rat
          G Protein Coupled Receptors 384HT in human mouse rat
          Hypertension in human mouse rat

Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DRD5
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRD5
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DRD5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DRD5 gene from 3/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves DRD51 dopamine receptor D5 75.97(n)
77.78(a)
  428795  XM_426351.3  XP_426351.3 
lizard
(Anolis carolinensis)
Reptilia DRD56
--
--
68(a)
50(a)
1 ↔ many
1 ↔ many
GL343236.1(531475-532791)
GL343219.1(1203755-1205460)
zebrafish
(Danio rerio)
Actinopterygii LOC5635671 D(5)-like dopamine receptor-like 68.64(n)
65.55(a)
  563567  XM_686933.3  XP_692025.3 


ENSEMBL Gene Tree for DRD5 (if available)
TreeFam Gene Tree for DRD5 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DRD5 gene
TAAR62  HTR2A2  HTR62  TAAR22  ADRB12  TAAR82  HRH22  HTR2B2  
DRD12  HTR2C2  TAAR12  ADRB22  HTR42  ADRB32  TAAR52  
10 SIMAP similar genes for DRD5 using alignment to 1 protein entry:     DRD5_HUMAN:
DRD5P2    DRD5P1    DRD1    ADRB2    ADRA1D    HTR4
HTR4B    ADRA1A    ADRB1    HTR1D

DRD5 for paralogs           About GeneDecksing


5 Pseudogenes.org Pseudogenes for DRD5
PGOHUM00000244982 PGOHUM00000240174 PGOHUM00000263277 PGOHUM00000263281 PGOHUM00000263282


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DRD5
     2 CNVs: 2497 3479
Human Gene Mutation Database (HGMD): DRD5
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DRD5
DNA2.0 Custom Variant and Variant Library Synthesis for DRD5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DRD5 for disorders           About GeneDecksing

OMIM gene information: 126453   
OMIM disorders: 606798  143465  
UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
  • Defects in DRD5 are a cause of benign essential blepharospasm (BEB) [MIM:606798]. BEB is a primary focal
  • dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle
    contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye
    irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The
    visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional
    blindness

    20/35 diseases for DRD5 (see all 35):    About MalaCards
    attention deficit hyperactivity disorder    gilles de la tourette syndrome    blepharospasm, primary benign    blepharospasm
    migraine without aura    dystonia, primary cervical    focal dystonia    substance dependence
    pathological gambling    substance abuse    bipolar affective disorder    autism spectrum disorder
    conduct disorder    tourette syndrome    nicotine dependence    essential hypertension
    cervical dystonia    anorexia nervosa    mutism    wolfram syndrome

    4 diseases from the University of Copenhagen DISEASES database for DRD5:
    Attention deficit hyperactivity disorder     Conduct disorder     Schizophrenia     Substance dependence

    10/11 Novoseek disease relationships for DRD5 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    attention-deficit hyperactivity disorder 82.6 12 11032390 (2), 15578613 (1), 18164132 (1), 15389755 (1) (see all 11)
    focal dystonia 53.5 3 14581671 (1), 17133500 (1)
    schizophrenia 46.4 14 11304828 (5), 9702739 (2), 16459247 (1), 9686426 (1) (see all 9)
    blepharospasm 39.7 2 11781417 (1), 17133500 (1)
    bipolar disorder 37.2 6 11304828 (3), 10578238 (1), 9702739 (1), 9774780 (1)
    substance dependence 36.3 3 9583233 (1), 11054773 (1)
    conduct disorder 36 1 17579368 (1)
    genetic susceptibility 27.7 3 9034008 (1), 19772578 (1)
    psychiatric disorder 26.1 3 9583233 (1), 11304828 (1)
    migraine 17.3 4 8731424 (2), 12967601 (1), 19772578 (1)

    Genetic Association Database (GAD): DRD5
    Human Genome Epidemiology (HuGE) Navigator: DRD5 (54 documents)

    Export disorders for DRD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DRD5 gene, integrated from 9 sources (see all 209):
    (articles sorted by number of sources associating them with DRD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. (PubMed id 11781417)1, 2, 4, 9 Misbahuddin A....Warner T.T. (2002)
    2. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. (PubMed id 7633397)1, 2, 4, 9 Sobell J.L.... Sommer S.S. (1995)
    3. Role of the dopamine D5 receptor (DRD5) as a susceptibility gene for cervical dystonia. (PubMed id 12700316)1, 4, 9 Brancati F....Dallapiccola B. (2003)
    4. An association study of DRD5 with smoking initiation and progression to nicotine dependence. (PubMed id 11353446)1, 4, 9 Sullivan P.F....Straub R.E. (2001)
    5. Candidate gene studies in focal dystonia. (PubMed id 14581671)1, 4, 9 Sibbing D....Bandmann O. (2003)
    6. Antisociality, substance dependence, and the DRD5 gene: a preliminary study. (PubMed id 11054773)1, 4, 9 Vanyukov M.M....Tarter R.E. (2000)
    7. The human D5 dopamine receptor (DRD5) maps on chromosome 4. (PubMed id 1774076)1, 3, 9 Polymeropoulos M.H....Merril C.R. (1991)
    8. Dopamine receptor gene polymorphisms in Guangzhou Hans. (PubMed id 11024217)1, 4, 9 Wang J....Zhu Y. (2000)
    9. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. (PubMed id 1826762)1, 2, 9 Sunahara R.K.... Niznik H.B. (1991)
    10. No association between 12 dopaminergic genes and schizophrenia in a large Dutch sample. (PubMed id 15635698)1, 4, 9 Hoogendoorn M.L....Sinke R.J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1816 HGNC: 3026 AceView: DRD5 Ensembl:ENSG00000169676 euGenes: HUgn1816
    ECgene: DRD5 Kegg: 1816 H-InvDB: DRD5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DRD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DRD5 gene:
    Search GeneIP for patents involving DRD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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