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Aliases for DRD5 Gene

Aliases for DRD5 Gene

  • Dopamine Receptor D5 2 3 5
  • D1beta Dopamine Receptor 3 4
  • D(5) Dopamine Receptor 3 4
  • Dopamine D5 Receptor 3 4
  • DRD1L2 3 4
  • DRD1B 3 4
  • Dopamine Receptor D1B 3
  • DBDR 3

External Ids for DRD5 Gene

Previous HGNC Symbols for DRD5 Gene

  • DRD1L2

Previous GeneCards Identifiers for DRD5 Gene

  • GC04P009453
  • GC04M009734
  • GC04P009534
  • GC04P009459
  • GC04P009392
  • GC04P009117

Summaries for DRD5 Gene

Entrez Gene Summary for DRD5 Gene

  • This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD5 Gene

DRD5 (Dopamine Receptor D5) is a Protein Coding gene. Diseases associated with DRD5 include blepharospasm, primary benign and attention deficit-hyperactivity disorder. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for DRD5 Gene

  • Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for DRD5 Gene

  • D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.

Gene Wiki entry for DRD5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD5 Gene

Genomics for DRD5 Gene

Regulatory Elements for DRD5 Gene

Genomic Location for DRD5 Gene

Chromosome:
4
Start:
9,781,634 bp from pter
End:
9,784,009 bp from pter
Size:
2,376 bases
Orientation:
Plus strand

Genomic View for DRD5 Gene

Genes around DRD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD5 Gene

Proteins for DRD5 Gene

  • Protein details for DRD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21918-DRD5_HUMAN
    Recommended name:
    D(1B) dopamine receptor
    Protein Accession:
    P21918
    Secondary Accessions:
    • B2R9S3
    • Q8NEQ8

    Protein attributes for DRD5 Gene

    Size:
    477 amino acids
    Molecular mass:
    52951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DRD5 Gene

Proteomics data for DRD5 Gene at MOPED

Post-translational modifications for DRD5 Gene

No Post-translational modifications

Other Protein References for DRD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for DRD5 (Dopamine D5 R/DRD5)

No data available for DME Specific Peptides for DRD5 Gene

Domains & Families for DRD5 Gene

Gene Families for DRD5 Gene

Suggested Antigen Peptide Sequences for DRD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21918

UniProtKB/Swiss-Prot:

DRD5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD5: view

Function for DRD5 Gene

Molecular function for DRD5 Gene

GENATLAS Biochemistry:
dopamine receptor D5,high affinity,adenylate cyclase stimulating,G protein coupled receptor superfamily,complexing with GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions between these receptor systems
UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035240 dopamine binding IDA 1826762
genes like me logo Genes that share ontologies with DRD5: view
genes like me logo Genes that share phenotypes with DRD5: view

Animal Models for DRD5 Gene

MGI Knock Outs for DRD5:

Animal Model Products

miRNA for DRD5 Gene

miRTarBase miRNAs that target DRD5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRD5 Gene

Localization for DRD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD5 Gene COMPARTMENTS Subcellular localization image for DRD5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9457173
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DRD5: view

Pathways & Interactions for DRD5 Gene

genes like me logo Genes that share pathways with DRD5: view

Gene Ontology (GO) - Biological Process for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic NAS 11036203
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA,IDA 11500503
GO:0007190 activation of adenylate cyclase activity TAS 9457173
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IDA 1826762
genes like me logo Genes that share ontologies with DRD5: view

No data available for SIGNOR curated interactions for DRD5 Gene

Drugs & Compounds for DRD5 Gene

(75) Drugs for DRD5 Gene - From: IUPHAR, DGIdb, DrugBank, HMDB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist, agonist, Target, Target 3084
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 34
Bromocriptine Approved, Investigational Pharma Antagonist, agonist, Target 29
Cabergoline Approved Pharma Antagonist, agonist, Target, Target 45
Lisuride Approved Pharma Antagonist, agonist, Target, antagonist 5

(9) Additional Compounds for DRD5 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-HT
Full agonist, Agonist
cis flupentixol
Antagonist
NPA
Full agonist, Agonist
A 68930 hydrochloride
130465-39-3
CY 208-243
100999-26-6

(5) Tocris Compounds for DRD5 Gene

Compound Action Cas Number
A 68930 hydrochloride Potent, selective D1-like agonist 130465-39-3
CY 208-243 Selective D1-like agonist 100999-26-6
Dihydrexidine hydrochloride Selective D1-like agonist 158704-02-0
SKF 38393 hydrobromide Selective D1-like agonist 20012-10-6
SKF 81297 hydrobromide D1 agonist 67287-39-2

(24) ApexBio Compounds for DRD5 Gene

Compound Action Cas Number
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Aripiprazole Antipsychotic 129722-12-9
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Haloperidol Antipsychotic drug 52-86-8
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Metoclopramide Dopamine receptor antagonist 364-62-5
Paliperidone 144598-75-4
PD128907 HCl 112960-16-4
Pergolide mesylate 66104-23-2
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Sitaxentan sodium 210421-74-2
genes like me logo Genes that share compounds with DRD5: view

Transcripts for DRD5 Gene

mRNA/cDNA for DRD5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD5 Gene

Dopamine receptor D5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRD5 Gene

No ASD Table

Relevant External Links for DRD5 Gene

GeneLoc Exon Structure for
DRD5
ECgene alternative splicing isoforms for
DRD5

Expression for DRD5 Gene

mRNA expression in normal human tissues for DRD5 Gene

mRNA differential expression in normal tissues according to GTEx for DRD5 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x10.1), Brain - Cortex (x5.5), Brain - Hippocampus (x5.1), Brain - Frontal Cortex (BA9) (x4.7), Brain - Putamen (basal ganglia) (x4.6), and Brain - Amygdala (x4.4).

SOURCE GeneReport for Unigene cluster for DRD5 Gene Hs.380681

mRNA Expression by UniProt/SwissProt for DRD5 Gene

P21918-DRD5_HUMAN
Tissue specificity: Neuron-specific, localized primarily within limbic regions of the brain.
genes like me logo Genes that share expression patterns with DRD5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DRD5 Gene

Orthologs for DRD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DRD5 35
  • 86.84 (n)
  • 85.56 (a)
DBDR 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRD5 35
  • 89.03 (n)
  • 87.34 (a)
DRD5 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd5 35
  • 83.16 (n)
  • 84.08 (a)
Drd5 16
Drd5 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DRD5 35
  • 98.95 (n)
  • 98.53 (a)
DRD5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd5 35
  • 82.91 (n)
  • 83.62 (a)
oppossum
(Monodelphis domestica)
Mammalia DRD5 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRD5 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA2L 35
  • 75.67 (n)
  • 77.57 (a)
DRD5 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD5 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495174 35
  • 69.35 (n)
  • 71.43 (a)
zebrafish
(Danio rerio)
Actinopterygii drd7 35
  • 64.2 (n)
  • 63.01 (a)
DRD5 (1 of 2) 36
  • 63 (a)
OneToMany
DRD5 (2 of 2) 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 34 (a)
DopR 37
  • 36 (a)
DopR 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-1 36
  • 29 (a)
OneToMany
Species with no ortholog for DRD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD5 Gene

ENSEMBL:
Gene Tree for DRD5 (if available)
TreeFam:
Gene Tree for DRD5 (if available)

Paralogs for DRD5 Gene

Paralogs for DRD5 Gene

(10) SIMAP similar genes for DRD5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DRD5: view

Variants for DRD5 Gene

Sequence variations from dbSNP and Humsavar for DRD5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_003458 -
VAR_003459 -
VAR_003460 -
VAR_003461 -
VAR_011837 -

Structural Variations from Database of Genomic Variants (DGV) for DRD5 Gene

Variant ID Type Subtype PubMed ID
dgv1570e1 CNV Complex 17122850
dgv1577e1 CNV Complex 17122850
essv18917 CNV CNV 17122850
nsv878667 CNV Gain 21882294
nsv878669 CNV Gain 21882294
dgv5473n71 CNV Gain 21882294
nsv482087 CNV Gain 20164927

Variation tolerance for DRD5 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRD5 Gene

HapMap Linkage Disequilibrium report
DRD5
Human Gene Mutation Database (HGMD)
DRD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD5 Gene

Disorders for DRD5 Gene

MalaCards: The human disease database

(22) MalaCards diseases for DRD5 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
blepharospasm, primary benign
  • beb
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
blepharospasm
  • beb
focal dystonia
  • focal hand dystonia
meige syndrome
  • blepharospasm - oromandibular dystonia
- elite association - COSMIC cancer census association via MalaCards
Search DRD5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DRD5_HUMAN
  • Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. {ECO:0000269 PubMed:11781417}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for DRD5

Genetic Association Database (GAD)
DRD5
Human Genome Epidemiology (HuGE) Navigator
DRD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRD5
genes like me logo Genes that share disorders with DRD5: view

No data available for Genatlas for DRD5 Gene

Publications for DRD5 Gene

  1. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. (PMID: 11781417) Misbahuddin A. … Warner T.T. (Neurology 2002) 3 4 48 67
  2. The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. (PMID: 17301410) Ostadali M.R. … Boulhari J. (Iran J Allergy Asthma Immunol 2004) 23 25 26
  3. The human D5 dopamine receptor (DRD5) maps on chromosome 4. (PMID: 1774076) Polymeropoulos M.H. … Merril C.R. (Genomics 1991) 2 3 23
  4. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. (PMID: 18563476) Langley K. … Thapar A. (Eur Child Adolesc Psychiatry 2009) 3 23
  5. Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers. (PMID: 19171671) So C.H. … George S.R. (Mol. Pharmacol. 2009) 3 23

Products for DRD5 Gene

Sources for DRD5 Gene

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