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DRD5 Gene

protein-coding   GIFtS: 69
GCID: GC04P009783

Dopamine Receptor D5


(Previous symbol: DRD1L2)
  See DRD5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dopamine Receptor D51 2     D1beta Dopamine Receptor2 3
DRD1L21 2 3 5     DBDR2
DRD1B2 3 5     D(1B) Dopamine Receptor2
D(5) Dopamine Receptor2 3     Dopamine Receptor D1B2
Dopamine D5 Receptor2 3     

External Ids:    HGNC: 30261   Entrez Gene: 18162   Ensembl: ENSG000001696767   OMIM: 1264535   UniProtKB: P219183   

Export aliases for DRD5 gene to outside databases

Previous GC identifers: GC04P009453 GC04M009734 GC04P009534 GC04P009459 GC04P009392 GC04P009117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DRD5 Gene:
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which
stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a
10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes
1 and 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for DRD5 Gene:
DRD5 (dopamine receptor D5) is a protein-coding gene. Diseases associated with DRD5 include pathological gambling, and substance dependence. GO annotations related to this gene include dopamine binding and dopamine neurotransmitter receptor activity, coupled via Gs. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

summary for DRD5 Gene:
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor
G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly
homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1
receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution
(mainly limbic areas).

Gene Wiki entry for DRD5 (Dopamine receptor D5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006316.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DRD5 gene promoter:
         RORalpha1   PPAR-gamma1   Sp1   PPAR-gamma2   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRD5 promoter sequence
   Search Chromatin IP Primers for DRD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

DRD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRD5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P009783:  view genomic region     (about GC identifiers)

Start:
9,783,258 bp from pter      End:
9,785,633 bp from pter
Size:
2,376 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918 (See protein sequence)
Recommended Name: D(1B) dopamine receptor  
Size: 477 amino acids; 52951 Da
Secondary accessions: B2R9S3 Q8NEQ8

Explore the universe of human proteins at neXtProt for DRD5: NX_P21918

Explore proteomics data for DRD5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn222

  • See DRD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000789.1  
    ENSEMBL proteins: 
     ENSP00000306129  
    Reactome Protein details: P21918

    DRD5 Human Recombinant Protein Products:

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    Novus Biologicals DRD5 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DRD5

     
    Search eBioscience for Proteins for DRD5 

    DRD5 Antibody Products:

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    Search eBioscience for ELISAs for DRD5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DRD: GPCR / Class A : Dopamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: D5 receptor
    Dopamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000497 Dopamine_D5_rcpt
     IPR000929 Dopamine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21918

    ProtoNet protein and cluster: P21918

    2 Blocks protein domains:
    IPB000497 Dopamine 1B receptor signature
    IPB000929 Dopamine receptor signature


    UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with DRD5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRD5_HUMAN, P21918
    Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

         Genatlas biochemistry entry for DRD5:
    dopamine receptor D5,high affinity,adenylate cyclase stimulating,G protein coupled receptor superfamily,complexing
    with GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions
    between these receptor systems

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs TAS9457173
    GO:0004930G-protein coupled receptor activity ----
    GO:0004952dopamine neurotransmitter receptor activity IDA1826762
    GO:0035240dopamine binding IDA1826762
         
    Find genes that share ontologies with DRD5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DRD5:
     Decreased substrate adherent c  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Drd5):
     cardiovascular system  endocrine/exocrine gland  nervous system  normal  renal/urinary system 
     vision/eye 

    Find genes that share phenotypes with DRD5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Drd5tm1Sib for DRD5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRD5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DRD5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRD5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRD5

    miRNA
    Products:
        
    miRTarBase miRNAs that target DRD5:
    hsa-mir-335-5p (MIRT017477)

    Block miRNA regulation of human, mouse, rat DRD5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DRD5:
    hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidDRD5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat DRD5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DRD5 (NM_000798)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRD5_HUMAN, P21918: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9457173
    GO:0016021integral component of membrane ----
    GO:0031526brush border membrane IEA--

    Find genes that share ontologies with DRD5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DRD5 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Dopamine receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Transcription CREB pathway
    Development Ligand independent activation of ESR1 and ESR20.34
    Transcription CREB pathway0.34
    5Circadian entrainment
    Dopaminergic synapse0.37


    Find genes that share SuperPaths with DRD5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DRD5
        CDK5 Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 GeneGo (Thomson Reuters) Pathways for DRD5
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway

    2 BioSystems Pathways for DRD5
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for DRD5
        Dopamine receptors
    G alpha (s) signalling events


    3 Kegg Pathways  (Kegg details for DRD5):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Dopaminergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DRD5: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DRD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DRD5 (P219183 ENSP000003061294) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABRG2P185073, ENSP000004107324I2D: score=1 STRING: ENSP00000410732
    GNA12Q031133, ENSP000002753644I2D: score=2 STRING: ENSP00000275364
    GNA13Q143443, ENSP000004007174I2D: score=2 STRING: ENSP00000400717
    GNAZP190863, ENSP000002489964I2D: score=1 STRING: ENSP00000248996
    NCS1P621663, ENSP000003614754I2D: score=2 STRING: ENSP00000361475
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic NAS11036203
    GO:0001975response to amphetamine IEA--
    GO:0001992regulation of systemic arterial blood pressure by vasopressin IEA--
    GO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA--
    GO:0006874cellular calcium ion homeostasis TAS9457173

    Find genes that share ontologies with DRD5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DRD5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 38393 hydrobromideSelective D1-like agonist[81633-77-4]
    SCH 39166 hydrobromideHigh affinity D1/D5 receptor antagonist--
    SKF 83959 hydrobromideD1-like partial agonist[80751-85-5]
    SKF 81297 hydrobromideD1 agonist[71636-61-8]
    SCH 23390 hydrochlorideStandard selective D1-like antagonist. Also 5-HT2C agonist[125941-87-9]

    1 HMDB Compound for DRD5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

    Selected DrugBank Compounds for DRD5 (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FenoldopamFenodopam mesylate (see all 3)67227-57-0targetagonist17139284 19293728 8103596 17016423
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist11436517 18691132 16982285
    CarphenazineCarfenazine (see all 2)2622-30-2targetantagonist4861216 4887393 4889058
    Levodopa3,4-dihydroxyphenylalanine (see all 4)59-92-7targetagonist11978145 18549347 9633680
    ApomorphineApomorfin (see all 9)41372-20-7targetagonist11752352 18691132
    Olanzapine-- 132539-06-1targetantagonist10227113 17848919
    Zuclopenthixolzuclopenthixol acetate (see all 5)53772-83-1targetantagonist1822319 10222441
    AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist partial agonist17848919
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist18691132
    DopamineDopamin (see all 6)51-61-6targetagonist17301410

    Selected IUPHAR Ligands for DRD5 (D5 receptor) (see all 30)    About this table
    LigandTypeActionAffinityPubmed IDs
    SCH-23390
    AntagonistAntagonist7.5 - 9.51826762
    SKF-83556
    AntagonistAntagonist9.41826762
    [3H]SCH-23390
    AntagonistAntagonist9.28051291
    lisuride
    AgonistPartial agonist8.512388666
    ecopipam
    AntagonistAntagonist8.31826762
    cis flupentixol
    AntagonistAntagonist8.11826762
    fluphenazine
    AntagonistAntagonist7.91826762
    apomorphine
    AgonistPartial agonist6.4 - 7.812388666 1826762
    (+)-SKF-82526
    AgonistFull agonist7.81826762
    cabergoline
    AgonistFull agonist7.712388666

    7 Novoseek inferred chemical compound relationships for DRD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 78.6 69 10337922 (3), 10578238 (2), 11036203 (2), 14699430 (2) (see all 44)
    methylphenidate 47.8 2 10889550 (1), 15108184 (1)
    catecholamine 26.9 1 8522958 (1)
    clozapine 20.9 1 16395606 (1)
    tyrosine 0 3 16459247 (1), 11449400 (1)
    cyclic amp 0 2 7609904 (1)
    norepinephrine 0 1 18480676 (1)



    Find genes that share compounds with DRD5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DRD5 gene: 
    NM_000798.4  

    Unigene Cluster for DRD5:

    Dopamine receptor D5
    Hs.380681  [show with all ESTs]
    Unigene Representative Sequence: NM_000798
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304374(uc003gmb.4)
    miRNA
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    hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidDRD5 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DRD5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRD5
      QuantiTect SYBR Green Assays in human, mouse, rat DRD5
      QuantiFast Probe-based Assays in human, mouse, rat DRD5

    Additional mRNA sequence: 

    AK313897.1 AY136750.1 BC009748.2 

    1 DOTS entry:

    DT.97775741 

    13 AceView cDNA sequences:

    BE746231 BX283486 CN831342 AY136750 CD609573 BC009748 NM_000798 BM805454 
    CN831353 BV200290 BV200289 BM718235 BQ186987 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DRD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTCTGTG
    DRD5 Expression
    About this image


    DRD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Stomach (Gastrointestinal Tract)
    DRD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380681

    UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
    Tissue specificity: Neuron-specific, localized primarily within limbic regions of the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DRD5: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DRD5
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    QuantiFast Probe-based Assays in human, mouse, rat DRD5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DRD5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drd51 , 5 dopamine receptor D51, 5 83.16(n)1
    84.08(a)1
      5 (20.40 cM)5
    134921  NM_013503.21  NP_038531.11 
     383195095 
    chicken
    (Gallus gallus)
    Aves SPATA2L1 spermatogenesis associated 2-like 75.67(n)
    77.57(a)
      427552  XM_004936301.1  XP_004936358.1 
    lizard
    (Anolis carolinensis)
    Reptilia DRD56
    dopamine receptor D5
    67(a)
    1 ↔ 1
    GL343236.1(531484-532791)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004951741 D(1B) dopamine receptor-like 69.35(n)
    71.43(a)
      100495174  XM_004911239.1  XP_004911296.1 
    zebrafish
    (Danio rerio)
    Actinopterygii drd71 dopamine receptor D7 64.2(n)
    63.01(a)
      100002285  NM_001113643.1  NP_001107115.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR3 dopamine receptor signaling pathway
    G-protein more
    36(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea dop-16
    Protein DOP-1, isoform a
    29(a)
    1 → many
    X(4411380-4416079) WBGene00001052


    ENSEMBL Gene Tree for DRD5 (if available)
    TreeFam Gene Tree for DRD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRD5 gene
    TAAR62  HTR62  TAAR22  ADRB12  TAAR92  TAAR82  HRH22  DRD12  
    TAAR12  ADRB22  HTR42  ADRB32  TAAR52  
    10 SIMAP similar genes for DRD5 using alignment to 1 protein entry:     DRD5_HUMAN:
    DRD5P2    DRD5P1    DRD1    ADRB2    ADRA1D    HTR4
    HTR4B    ADRA1A    ADRB1    HTR1D

    Find genes that share paralogs with DRD5           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for DRD5
    PGOHUM00000244982 PGOHUM00000240174 PGOHUM00000263277 PGOHUM00000263281 PGOHUM00000263282


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DRD5 (see all 209)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777845091,2
    Cuntested19734282(+) AGATCC/TGCAGG 2 R C mis10--------
    rs125044321,2
    H--9117702(+) GCCCCA/TCAGTG 1 -- ut510--------
    rs1893118861,2
    --9731092(+) CTCACA/GATCCA 1 -- us2k10--------
    rs1807990041,2
    --9731144(+) CCACCA/GTGCAC 1 -- us2k10--------
    rs1408144891,2
    C--9731179(+) TAGCA-/TCTCTCT 1 -- us2k10--------
    rs612309621,2
    C--9731208(+) CTCTC-/CC/TC 
            
    CCTCC
    1 -- us2k10--------
    rs788766481,2
    C,F--9731332(+) CTCTTG/TTCTGA 1 -- us2k10--------
    rs1499057591,2
    --9731373(+) AGATAA/GGGGAA 1 -- us2k10--------
    rs1903552791,2
    --9731375(+) ATAGGA/GGAAGG 1 -- us2k10--------
    rs1155171511,2
    F--9731389(+) TTCCAG/AGTTGA 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for DRD5 (9783258 - 9785633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DRD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482087CNV Gain20164927
    dgv5473n71CNV Gain21882294
    nsv878667CNV Gain21882294
    nsv878669CNV Gain21882294
    essv18917CNV CNV17122850
    dgv1570e1CNV Complex17122850
    dgv1577e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): DRD5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DRD5
    DNA2.0 Custom Variant and Variant Library Synthesis for DRD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 126453   
    OMIM disorders: 606798  143465  
    UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
  • Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis
    oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to
    abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent
    blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance
    is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
    Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry

  • 20 diseases for DRD5:    
    About MalaCards
    pathological gambling    substance dependence    cervical dystonia    blepharospasm
    conduct disorder    blepharospasm, primary benign    dystonia, primary cervical    focal dystonia
    dystonia 24    migraine without aura    wolfram syndrome    substance abuse
    attention deficit hyperactivity disorder    gilles de la tourette syndrome    autism spectrum disorder    nicotine dependence
    bipolar disorder    alcohol dependence    essential hypertension    schizophrenia

    5 diseases from the University of Copenhagen DISEASES database for DRD5:
    Attention deficit hyperactivity disorder     Conduct disorder     Gilles de la Tourette syndrome     Schizophrenia
    Substance dependence

    Find genes that share disorders with DRD5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DRD5 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    attention-deficit hyperactivity disorder 82.6 12 11032390 (2), 15578613 (1), 18164132 (1), 15389755 (1) (see all 11)
    focal dystonia 53.5 3 14581671 (1), 17133500 (1)
    schizophrenia 46.4 14 11304828 (5), 9702739 (2), 16459247 (1), 9686426 (1) (see all 9)
    blepharospasm 39.7 2 11781417 (1), 17133500 (1)
    bipolar disorder 37.2 6 11304828 (3), 10578238 (1), 9702739 (1), 9774780 (1)
    substance dependence 36.3 3 9583233 (1), 11054773 (1)
    conduct disorder 36 1 17579368 (1)
    genetic susceptibility 27.7 3 9034008 (1), 19772578 (1)
    psychiatric disorder 26.1 3 9583233 (1), 11304828 (1)
    migraine 17.3 4 8731424 (2), 12967601 (1), 19772578 (1)

    Genetic Association Database (GAD): DRD5
    Human Genome Epidemiology (HuGE) Navigator: DRD5 (54 documents)

    Export disorders for DRD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRD5 gene, integrated from 10 sources (see all 213):
    (articles sorted by number of sources associating them with DRD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. (PubMed id 11781417)1, 2, 4, 9 Misbahuddin A....Warner T.T. (Neurology 2002)
    2. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. (PubMed id 7633397)1, 2, 4, 9 Sobell J.L.... Sommer S.S. (Hum. Mol. Genet. 1995)
    3. Role of the dopamine D5 receptor (DRD5) as a susceptibility gene for cervical dystonia. (PubMed id 12700316)1, 4, 9 Brancati F....Dallapiccola B. (J. Neurol. Neurosurg. Psychiatr. 2003)
    4. An association study of DRD5 with smoking initiation and progression to nicotine dependence. (PubMed id 11353446)1, 4, 9 Sullivan P.F....Straub R.E. (Am. J. Med. Genet. 2001)
    5. Candidate gene studies in focal dystonia. (PubMed id 14581671)1, 4, 9 Sibbing D....Bandmann O. (Neurology 2003)
    6. Antisociality, substance dependence, and the DRD5 gene: a preliminary study. (PubMed id 11054773)1, 4, 9 Vanyukov M.M....Tarter R.E. (Am. J. Med. Genet. 2000)
    7. The human D5 dopamine receptor (DRD5) maps on chromosome 4. (PubMed id 1774076)1, 3, 9 Polymeropoulos M.H....Merril C.R. (Genomics 1991)
    8. Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. (PubMed id 17501935)1, 4, 9 Lasky-Su J....Faraone S.V. (Ann. Hum. Genet. 2007)
    9. Dopamine receptor gene polymorphisms in Guangzhou Hans. (PubMed id 11024217)1, 4, 9 Wang J....Zhu Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000)
    10. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. (PubMed id 1826762)1, 2, 9 Sunahara R.K.... Niznik H.B. (Nature 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1816 HGNC: 3026 AceView: DRD5 Ensembl:ENSG00000169676 euGenes: HUgn1816
    ECgene: DRD5 Kegg: 1816 H-InvDB: DRD5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DRD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRD5 gene:
    Search GeneIP for patents involving DRD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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