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Aliases for DRD5 Gene

Aliases for DRD5 Gene

  • Dopamine Receptor D5 2 3
  • DRD1L2 3 4 6
  • DRD1B 3 4 6
  • D1beta Dopamine Receptor 3 4
  • D(5) Dopamine Receptor 3 4
  • Dopamine D5 Receptor 3 4
  • D(1B) Dopamine Receptor 3
  • Dopamine Receptor D1B 3
  • DBDR 3

External Ids for DRD5 Gene

Previous HGNC Symbols for DRD5 Gene

  • DRD1L2

Previous GeneCards Identifiers for DRD5 Gene

  • GC04P009453
  • GC04M009734
  • GC04P009534
  • GC04P009459
  • GC04P009392
  • GC04P009117

Summaries for DRD5 Gene

Entrez Gene Summary for DRD5 Gene

  • This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD5 Gene

DRD5 (Dopamine Receptor D5) is a Protein Coding gene. Diseases associated with DRD5 include blepharospasm, primary benign and blepharospasm. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include dopamine binding and dopamine neurotransmitter receptor activity, coupled via Gs. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for DRD5 Gene

  • Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for DRD5 Gene

  • D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1 receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution (mainly limbic areas).

Gene Wiki entry for DRD5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD5 Gene

Genomics for DRD5 Gene

Regulatory Elements for DRD5 Gene

Genomic Location for DRD5 Gene

Start:
9,781,634 bp from pter
End:
9,784,009 bp from pter
Size:
2,376 bases
Orientation:
Plus strand

Genomic View for DRD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD5 Gene

Proteins for DRD5 Gene

  • Protein details for DRD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21918-DRD5_HUMAN
    Recommended name:
    D(1B) dopamine receptor
    Protein Accession:
    P21918
    Secondary Accessions:
    • B2R9S3
    • Q8NEQ8

    Protein attributes for DRD5 Gene

    Size:
    477 amino acids
    Molecular mass:
    52951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DRD5 Gene

Proteomics data for DRD5 Gene at MOPED

Post-translational modifications for DRD5 Gene

Other Protein References for DRD5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DRD5 Gene

Domains for DRD5 Gene

Gene Families for DRD5 Gene

HGNC:
  • DRD :GPCR / Class A : Dopamine receptors
IUPHAR :

Suggested Antigen Peptide Sequences for DRD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21918

UniProtKB/Swiss-Prot:

DRD5_HUMAN :
  • P21918
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD5: view

Function for DRD5 Gene

Molecular function for DRD5 Gene

GENATLAS Biochemistry: dopamine receptor D5,high affinity,adenylate cyclase stimulating,G protein coupled receptor superfamily,complexing with GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions between these receptor systems
UniProtKB/Swiss-Prot Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs TAS 9457173
GO:0004930 G-protein coupled receptor activity --
GO:0004952 dopamine neurotransmitter receptor activity IDA 1826762
GO:0008227 G-protein coupled amine receptor activity IBA --
GO:0035240 dopamine binding IDA 1826762
genes like me logo Genes that share ontologies with DRD5: view
genes like me logo Genes that share phenotypes with DRD5: view

Animal Models for DRD5 Gene

MGI Knock Outs for DRD5:

miRNA for DRD5 Gene

miRTarBase miRNAs that target DRD5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DRD5 Gene

Localization for DRD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD5 Gene COMPARTMENTS Subcellular localization image for DRD5 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9457173
GO:0016021 integral component of membrane --
GO:0031526 brush border membrane IEA --
genes like me logo Genes that share ontologies with DRD5: view

Pathways for DRD5 Gene

genes like me logo Genes that share pathways with DRD5: view

Gene Ontology (GO) - Biological Process for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic NAS 11036203
GO:0001975 response to amphetamine IEA --
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0006874 cellular calcium ion homeostasis TAS 9457173
genes like me logo Genes that share ontologies with DRD5: view

Compounds for DRD5 Gene

(5) Tocris Compounds for DRD5 Gene

Compound Action Cas Number
Dihydrexidine hydrochloride Selective D1-like agonist [158704-02-0]
SCH 23390 hydrochloride Standard selective D1-like antagonist; also 5-HT2C agonist [125941-87-9]
SCH 39166 hydrobromide High affinity D1/D5 receptor antagonist [1227675-51-5]
SKF 38393 hydrobromide Selective D1-like agonist [20012-10-6]
SKF 81297 hydrobromide D1 agonist [67287-39-2]

(1) HMDB Compounds for DRD5 Gene

Compound Synonyms Cas Number PubMed IDs
Dopamine
  • 2-(3,4-Dihydroxyphenyl)ethylamine
62-31-7

(18) Drugbank Compounds for DRD5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist partial agonist
Bromocriptine
  • Bromergocryptine
25614-03-3 target agonist
Cabergoline
  • Cabergolina [Spanish]
81409-90-7 target agonist
Carphenazine
  • Carfenazine
2622-30-2 target antagonist

(30) IUPHAR Ligand for DRD5 Gene

Ligand Type Action Affinity Pubmed IDs
SCH-23390 Antagonist Antagonist 9.5
SKF-83556 Antagonist Antagonist 9.5
[3H]SCH-23390 Antagonist Antagonist 9.5
(+)-butaclamol Antagonist Antagonist 8.5
cis flupentixol Antagonist Antagonist 8.4
ecopipam Antagonist Antagonist 8.3
fluphenazine Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
(+)-SKF-82526 Agonist Full agonist 7.6
NPA Agonist Full agonist 7.4
lisuride Agonist Partial agonist 7.2
beta-ergocriptine Agonist Full agonist 6.9
A68930 Agonist Agonist 6.82
SKF-38393 Agonist Full agonist 6.8
cabergoline Agonist Full agonist 6.7
clozapine Antagonist Antagonist 6.7
spiperone Antagonist Antagonist 6.7
pergolide Agonist Full agonist 6.5
(+)-ADTN Agonist Full agonist 6.4
ketanserin Inhibitor Inhibition 6.3
bromocriptine Agonist Partial agonist 6.2
SKF-76783 Agonist Full agonist 6.2
haloperidol Antagonist Antagonist 6.1
(-)-SKF-82526 Agonist Full agonist 6.1
dopamine Agonist Full agonist 5.6
rotigotine Agonist Full agonist 5.6
apomorphine Activator Activation 5.1
noradrenaline Agonist Full agonist 4.3
5-HT Inhibitor Inhibition 2.2
chlorpromazine Channel blocker None

(7) Novoseek inferred chemical compound relationships for DRD5 Gene

Compound -log(P) Hits PubMed IDs
dopamine 78.6 52
methylphenidate 47.8 2
catecholamine 26.9 1
clozapine 20.9 1
tyrosine 0 2
genes like me logo Genes that share compounds with DRD5: view

Transcripts for DRD5 Gene

mRNA/cDNA for DRD5 Gene

(13) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD5 Gene

Dopamine receptor D5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRD5 Gene

No ASD Table

Relevant External Links for DRD5 Gene

GeneLoc Exon Structure for
DRD5
ECgene alternative splicing isoforms for
DRD5

Expression for DRD5 Gene

mRNA expression in normal human tissues for DRD5 Gene

mRNA differential expression in normal tissues according to GTEx for DRD5 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (10.1), Brain - Cortex (5.5), Brain - Hippocampus (5.1), Brain - Frontal Cortex (BA9) (4.7), Brain - Putamen (basal ganglia) (4.6), and Brain - Amygdala (4.4).

SOURCE GeneReport for Unigene cluster for DRD5 Gene Hs.380681

mRNA Expression by UniProt/SwissProt for DRD5 Gene

P21918-DRD5_HUMAN
Tissue specificity: Neuron-specific, localized primarily within limbic regions of the brain.
genes like me logo Genes that share expressions with DRD5: view

No data available for Protein expression for DRD5 Gene

Orthologs for DRD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD5 35
  • 98.95 (n)
  • 98.53 (a)
DRD5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DBDR 36
  • 84 (a)
OneToOne
DRD5 35
  • 86.84 (n)
  • 85.56 (a)
dog
(Canis familiaris)
Mammalia DRD5 35
  • 89.03 (n)
  • 87.34 (a)
DRD5 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd5 35
  • 83.16 (n)
  • 84.08 (a)
Drd5 16
Drd5 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRD5 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRD5 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd5 35
  • 82.91 (n)
  • 83.62 (a)
chicken
(Gallus gallus)
Aves DRD5 36
  • 76 (a)
OneToOne
SPATA2L 35
  • 75.67 (n)
  • 77.57 (a)
lizard
(Anolis carolinensis)
Reptilia DRD5 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495174 35
  • 69.35 (n)
  • 71.43 (a)
zebrafish
(Danio rerio)
Actinopterygii DRD5 (1 of 2) 36
  • 63 (a)
OneToMany
DRD5 (2 of 2) 36
  • 70 (a)
OneToMany
drd7 35
  • 64.2 (n)
  • 63.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta DopR 36
  • 29 (a)
OneToMany
CG6919 37
  • 34 (a)
DopR 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-1 36
  • 29 (a)
OneToMany
Species with no ortholog for DRD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD5 Gene

ENSEMBL:
Gene Tree for DRD5 (if available)
TreeFam:
Gene Tree for DRD5 (if available)

Paralogs for DRD5 Gene

Paralogs for DRD5 Gene

Selected SIMAP similar genes for DRD5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DRD5: view

Variants for DRD5 Gene

Sequence variations from dbSNP and Humsavar for DRD5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_003458 -
VAR_003459 -
VAR_003460 -
VAR_003461 -
VAR_011837 -

Structural Variations from Database of Genomic Variants (DGV) for DRD5 Gene

Variant ID Type Subtype PubMed ID
dgv1570e1 CNV Complex 17122850
dgv1577e1 CNV Complex 17122850
essv18917 CNV CNV 17122850
nsv878667 CNV Gain 21882294
nsv878669 CNV Gain 21882294
dgv5473n71 CNV Gain 21882294
nsv482087 CNV Gain 20164927

Relevant External Links for DRD5 Gene

HapMap Linkage Disequilibrium report
DRD5
Human Gene Mutation Database (HGMD)
DRD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD5 Gene

Disorders for DRD5 Gene

(2) OMIM Diseases for DRD5 Gene (126453)

UniProtKB/Swiss-Prot

DRD5_HUMAN
  • Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. {ECO:0000269 PubMed:11781417}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(11) Novoseek inferred disease relationships for DRD5 Gene

Disease -log(P) Hits PubMed IDs
attention-deficit hyperactivity disorder 82.6 12
focal dystonia 53.5 2
schizophrenia 46.4 14
blepharospasm 39.7 2
bipolar disorder 37.2 6

Relevant External Links for DRD5

Genetic Association Database (GAD)
DRD5
Human Genome Epidemiology (HuGE) Navigator
DRD5
genes like me logo Genes that share disorders with DRD5: view

Publications for DRD5 Gene

  1. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. (PMID: 7633397) Sobell J.L. … Sommer S.S. (Hum. Mol. Genet. 1995) 3 4 23 48
  2. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. (PMID: 11781417) Misbahuddin A. … Warner T.T. (Neurology 2002) 3 4 23 48
  3. Antisociality, substance dependence, and the DRD5 gene: a preliminary study. (PMID: 11054773) Vanyukov M.M. … Tarter R.E. (Am. J. Med. Genet. 2000) 3 23 48
  4. An association study of DRD5 with smoking initiation and progression to nicotine dependence. (PMID: 11353446) Sullivan P.F. … Straub R.E. (Am. J. Med. Genet. 2001) 3 23 48
  5. Dopamine D5 receptor gene polymorphism and the risk of levodopa-induced motor fluctuations in patients with Parkinson's disease. (PMID: 11445276) Wang J. … Chen B. (Neurosci. Lett. 2001) 3 23 48

Products for DRD5 Gene

Sources for DRD5 Gene

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