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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DRD5 Gene

protein-coding   GIFtS: 68
GCID: GC04P009783

Dopamine Receptor D5


(Previous symbol: DRD1L2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dopamine Receptor D51 2     D1beta Dopamine Receptor2 3
DRD1L21 2 3 5     DBDR2
DRD1B2 3 5     D(1B) Dopamine Receptor2
D(5) Dopamine Receptor2 3     Dopamine Receptor D1B2
Dopamine D5 Receptor2 3     

External Ids:    HGNC: 30261   Entrez Gene: 18162   Ensembl: ENSG000001696767   OMIM: 1264535   UniProtKB: P219183   

Export aliases for DRD5 gene to outside databases

Previous GC identifers: GC04P009453 GC04M009734 GC04P009534 GC04P009459 GC04P009392 GC04P009117


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DRD5 Gene:
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which
stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a
10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes
1 and 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for DRD5 Gene: 
DRD5 (dopamine receptor D5) is a protein-coding gene. Diseases associated with DRD5 include cervical dystonia, and blepharospasm, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Amine ligand-binding receptors. GO annotations related to this gene include dopamine binding and dopamine neurotransmitter receptor activity, coupled via Gs. An important paralog of this gene is HTR6.

UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

summary for DRD5 Gene:
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor
G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly
homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1
receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution
(mainly limbic areas).

Gene Wiki entry for DRD5 (Dopamine receptor D5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DRD5 gene promoter:
         RORalpha1   PPAR-gamma1   Sp1   PPAR-gamma2   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DRD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

DRD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRD5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P009783:  view genomic region     (about GC identifiers)

Start:
9,783,258 bp from pter      End:
9,785,633 bp from pter
Size:
2,376 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918 (See protein sequence)
Recommended Name: D(1B) dopamine receptor  
Size: 477 amino acids; 52951 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2R9S3 Q8NEQ8

Explore the universe of human proteins at neXtProt for DRD5: NX_P21918

Explore proteomics data for DRD5 at MOPED 

DRD5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

DRD5 Protein Expression

REFSEQ proteins: NP_000789.1  
ENSEMBL proteins: 
 ENSP00000306129  
Reactome Protein details: P21918
Human Recombinant Protein Products for DRD5: 
EMD Millipore Purified and/or Recombinant DRD5 Protein
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
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Novus Biologicals DRD5 Protein
Novus Biologicals DRD5 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for DRD5 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS9457173
GO:0016021integral to membrane ----
GO:0031526brush border membrane IEA--

DRD5 for ontologies           About GeneDecksing



DRD5 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of DRD5
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Novus Biologicals DRD5 Antibodies
Abcam antibodies for DRD5
Cloud-Clone Corp. Antibodies for DRD5 
ThermoFisher Antibodies for DRD5
LSBio Antibodies in human, mouse, rat for DRD5 

Assay Products for DRD5: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DRD5
Browse R&D Systems for biochemical assays
GenScript DRD5-overexpressing Cell Line for Assay
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DRD5 
Cloud-Clone Corp. CLIAs for DRD5


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
DRD: GPCR / Class A : Dopamine receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: D5 receptor 
Dopamine receptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000497 Dopamine_D5_rcpt
 IPR000929 Dopamine_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P21918

ProtoNet protein and cluster: P21918

2 Blocks protein domains:
IPB000497 Dopamine 1B receptor signature
IPB000929 Dopamine receptor signature


UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Similarity: Belongs to the G-protein coupled receptor 1 family


DRD5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DRD5_HUMAN, P21918
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

     Genatlas biochemistry entry for DRD5:
dopamine receptor D5,high affinity,adenylate cyclase stimulating,G protein coupled receptor superfamily,complexing
with GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions
between these receptor systems

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs TAS9457173
GO:0004930G-protein coupled receptor activity ----
GO:0004952dopamine neurotransmitter receptor activity IDA1826762
GO:0035240dopamine binding IDA1826762
     
DRD5 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for DRD5:
 Decreased substrate adherent c  Increased gamma-H2AX phosphory 

     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Drd5):
 cardiovascular system  endocrine/exocrine gland  nervous system  normal  renal/urinary system 
 vision/eye 

DRD5 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Drd5tm1Sib for DRD5

   inGenious Targeting Laboratory - Custom generated mouse model solutions for DRD5 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DRD5

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRD5 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRD5 

miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate DRD5:
hsa-miR-942
SwitchGear 3'UTR luciferase reporter plasmidDRD5 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for DRD5
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Gene Editing
Products:
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Sirion Biotech Customized adenovirus for overexpression of DRD5

Clone
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EMD Millipore Clones for the Expression of DRD5
OriGene clones in human, mouse for DRD5 (see all 6)
OriGene ORF clones in mouse, rat for DRD5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DRD5 (NM_000798)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRD5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD5
Sirion Biotech Customized lentivirus for stable overexpression of DRD5 
                     Customized lentivirus expression plasmids for stable overexpression of DRD5 

Cell Line
Products:
     
GenScript DRD5-overexpressing Cell Line for Assay
Search LifeMap BioReagents cell lines for DRD5
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD5


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for DRD5 About   (see all 10)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
2Monoamine GPCRs
Monoamine GPCRs0.79
Amine ligand-binding receptors0.79
3Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
4Development Ligand-independent activation of ESR1 and ESR2
Transcription CREB pathway0.93
Development Ligand-independent activation of ESR1 and ESR20.34
5Circadian entrainment
Dopaminergic synapse0.37

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for DRD5
    Transcription CREB pathway
Development Ligand-independent activation of ESR1 and ESR2

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DRD5
    CDK5 Pathway
Dopamine-DARPP32 Feedback onto cAMP Pathway

2 GeneGo (Thomson Reuters) Pathways for DRD5
    Development Ligand-independent activation of ESR1 and ESR2
Transcription CREB pathway

2 BioSystems Pathways for DRD5
    GPCRs, Class A Rhodopsin-like
Monoamine GPCRs

5/8        Reactome Pathways for DRD5 (see all 8)
    GPCR downstream signaling
Signaling by GPCR
GPCR ligand binding
Class A/1 (Rhodopsin-like receptors)
Dopamine receptors


3         Kegg Pathways  (Kegg details for DRD5):
    Calcium signaling pathway
Neuroactive ligand-receptor interaction
Dopaminergic synapse


DRD5 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DRD5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/73 Interacting proteins for DRD5 (P219183 ENSP000003061294) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
InteractantInteraction Details
GeneCardExternal ID(s)
GABRG2P185073, ENSP000004107324I2D: score=1 STRING: ENSP00000410732
GNA12Q031133, ENSP000002753644I2D: score=2 STRING: ENSP00000275364
GNA13Q143443, ENSP000004007174I2D: score=2 STRING: ENSP00000400717
GNAZP190863, ENSP000002489964I2D: score=1 STRING: ENSP00000248996
NCS1P621663, ENSP000003614754I2D: score=2 STRING: ENSP00000361475
About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001963synaptic transmission, dopaminergic NAS11036203
GO:0001975response to amphetamine IEA--
GO:0001992regulation of systemic arterial blood pressure by vasopressin IEA--
GO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA--
GO:0006874cellular calcium ion homeostasis TAS9457173

DRD5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DRD5 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for DRD5 available from Tocris Bioscience    About this table
CompoundAction CAS #
SKF 38393 hydrobromideSelective D1-like agonist[81633-77-4]
SCH 39166 hydrobromideHigh affinity D1/D5 receptor antagonist--
SKF 83959 hydrobromideD1-like partial agonist[80751-85-5]
SKF 81297 hydrobromideD1 agonist[71636-61-8]
SCH 23390 hydrochlorideStandard selective D1-like antagonist. Also 5-HT2C agonist[125941-87-9]

1 HMDB Compound for DRD5    About this table
CompoundSynonyms CAS #PubMed Ids
Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

10/18 DrugBank Compounds for DRD5 (see all 18)    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
FenoldopamFenodopam mesylate (see all 3)67227-57-0targetagonist17139284 19293728 8103596 17016423
CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist11436517 18691132 16982285
CarphenazineCarfenazine (see all 2)2622-30-2targetantagonist4861216 4887393 4889058
Levodopa3,4-dihydroxyphenylalanine (see all 4)59-92-7targetagonist11978145 18549347 9633680
ApomorphineApomorfin (see all 9)41372-20-7targetagonist11752352 18691132
Olanzapine-- 132539-06-1targetantagonist10227113 17848919
Zuclopenthixolzuclopenthixol acetate (see all 5)53772-83-1targetantagonist1822319 10222441
AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist partial agonist17848919
BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist18691132
DopamineDopamin (see all 6)51-61-6targetagonist17301410

10/30 IUPHAR Ligands for DRD5 (D5 receptor) (see all 30)    About this table 
LigandTypeActionAffinityPubmed IDs
SCH-23390
AntagonistAntagonist7.5 - 9.51826762
SKF-83556
AntagonistAntagonist9.41826762
[3H]SCH-23390
AntagonistAntagonist9.28051291
lisuride
AgonistPartial agonist8.512388666
ecopipam
AntagonistAntagonist8.31826762
cis flupentixol
AntagonistAntagonist8.11826762
fluphenazine
AntagonistAntagonist7.91826762
apomorphine
AgonistPartial agonist6.4 - 7.812388666 1826762
(+)-SKF-82526
AgonistFull agonist7.81826762
cabergoline
AgonistFull agonist7.712388666

7 Novoseek inferred chemical compound relationships for DRD5 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dopamine 78.6 69 10337922 (3), 10578238 (2), 11036203 (2), 14699430 (2) (see all 44)
methylphenidate 47.8 2 10889550 (1), 15108184 (1)
catecholamine 26.9 1 8522958 (1)
clozapine 20.9 1 16395606 (1)
tyrosine 0 3 16459247 (1), 11449400 (1)
cyclic amp 0 2 7609904 (1)
norepinephrine 0 1 18480676 (1)

Search CenterWatch for drugs/clinical trials and news about DRD5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DRD5 gene: 
NM_000798.4  

Unigene Cluster for DRD5:

Dopamine receptor D5
Hs.380681  [show with all ESTs]
Unigene Representative Sequence: NM_000798
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000304374(uc003gmb.4)

miRNA
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Inhib. RNA
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OriGene ORF clones in mouse, rat for DRD5
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GenScript: all cDNA clones in your preferred vector: DRD5 (NM_000798)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRD5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD5
Sirion Biotech Customized lentivirus for stable overexpression of DRD5 
                     Customized lentivirus expression plasmids for stable overexpression of DRD5 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DRD5
OriGene qSTAR qPCR primer pairs in human, mouse for DRD5
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DRD5
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRD5
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRD5

Additional mRNA sequence: 

AK313897.1 AY136750.1 BC009748.2 

1 DOTS entry:

DT.97775741 

13 AceView cDNA sequences:

BX283486 BE746231 CN831342 CD609573 AY136750 NM_000798 BC009748 BV200289 
CN831353 BM805454 BV200290 BQ186987 BM718235 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DRD5 expression in normal human tissues (normalized intensities)      DRD5 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTTTCTGTG
DRD5 Expression
About this image


DRD5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 15 entries
         Thalamus
         Septum   
 
 Spinal Cord (Nervous System)    fully expand to see all 2 entries
         Dorsal Horn   
 
 Stomach (Gastrointestinal Tract)

See DRD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DRD5

SOURCE GeneReport for Unigene cluster: Hs.380681

UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
Tissue specificity: Neuron-specific, localized primarily within limbic regions of the brain

    SABiosciences Expression via Pathway-Focused PCR Arrays including DRD5: 
          Neurotransmitter Receptors in human mouse rat
          G Protein Coupled Receptors 384HT in human mouse rat
          Hypertension in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for DRD5
OriGene qSTAR qPCR primer pairs in human, mouse for DRD5
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DRD5
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRD5
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRD5
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DRD5 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Drd51 , 5 dopamine receptor D51, 5 83.16(n)1
84.08(a)1
  5 (20.40 cM)5
134921  NM_013503.21  NP_038531.11 
 383195095 
chicken
(Gallus gallus)
Aves DRD51 dopamine receptor D5 75.97(n)
77.78(a)
  428795  XM_426351.3  XP_426351.3 
lizard
(Anolis carolinensis)
Reptilia DRD56
--
Uncharacterized protein
68(a)
50(a)
1 ↔ 1
possible ortholog
GL343236.1(531484-532791)
GL343219.1(1203755-1205460)
zebrafish
(Danio rerio)
Actinopterygii LOC5635671 D(5)-like dopamine receptor-like 68.64(n)
65.55(a)
  563567  XM_686933.3  XP_692025.3 
fruit fly
(Drosophila melanogaster)
Insecta DopR3 dopamine receptor signaling pathway
G-protein more
36(a)
(best of 2)
    --


ENSEMBL Gene Tree for DRD5 (if available)
TreeFam Gene Tree for DRD5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DRD5 gene
HTR62  TAAR22  TAAR92  TAAR82  HRH22  ADRA1A2  TAAR52  TAAR62  
ADRB12  ADRA1B2  DRD12  TAAR12  ADRB22  HTR42  ADRB32  ADRA1D2  
10 SIMAP similar genes for DRD5 using alignment to 1 protein entry:     DRD5_HUMAN:
DRD5P2    DRD5P1    DRD1    ADRB2    ADRA1D    HTR4
HTR4B    ADRA1A    ADRB1    HTR1D

DRD5 for paralogs           About GeneDecksing


5 Pseudogenes.org Pseudogenes for DRD5
PGOHUM00000244982 PGOHUM00000240174 PGOHUM00000263277 PGOHUM00000263281 PGOHUM00000263282


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/209 SNPs in DRD5 are shown (see all 209)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs777845091,2
Cuntested19734282(+) AGATCC/TGCAGG 2 R C mis10--------
VAR_0242544
----see VAR_0242542 V I mis40--------
VAR_0034584
----see VAR_0034582 A V mis40--------
VAR_0292144
----see VAR_0292142 R H mis40--------
VAR_0034614
----see VAR_0034612 S C mis40--------
VAR_0292134
----see VAR_0292132 S N mis40--------
VAR_0034604
----see VAR_0034602 N D mis40--------
rs125044321,2
H--9117702(+) GCCCCA/TCAGTG 1 -- ut510--------
rs1893118861,2
--9731092(+) CTCACA/GATCCA 1 -- us2k10--------
rs1807990041,2
--9731144(+) CCACCA/GTGCAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for DRD5 (9783258 - 9785633 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for DRD5:    About this table     
Variant IDTypeSubtypePubMed ID
nsv482087CNV Gain20164927
dgv5473n71CNV Gain21882294
nsv878667CNV Gain21882294
nsv878669CNV Gain21882294
essv18917CNV CNV17122850
dgv1570e1CNV Complex17122850
dgv1577e1CNV Complex17122850


Human Gene Mutation Database (HGMD): DRD5
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing DRD5
DNA2.0 Custom Variant and Variant Library Synthesis for DRD5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 126453   
OMIM disorders: 606798  143465  
UniProtKB/Swiss-Prot: DRD5_HUMAN, P21918
  • Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis
    oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to
    abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent
    blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance
    is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
    Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry

  • 20/29 diseases for DRD5 (see all 29):    About MalaCards
    cervical dystonia    blepharospasm    substance dependence    blepharospasm, primary benign
    pathological gambling    focal dystonia    migraine without aura    wolfram syndrome
    attention deficit hyperactivity disorder    gilles de la tourette syndrome    substance abuse    mutism
    bipolar disorder    nicotine dependence    migraine    essential hypertension
    panic disorder    autism spectrum disorder    anorexia nervosa    schizophrenia

    5 diseases from the University of Copenhagen DISEASES database for DRD5:
    Attention deficit hyperactivity disorder     Conduct disorder     Gilles de la Tourette syndrome     Schizophrenia
    Substance dependence

    DRD5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for DRD5 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    attention-deficit hyperactivity disorder 82.6 12 11032390 (2), 15578613 (1), 18164132 (1), 15389755 (1) (see all 11)
    focal dystonia 53.5 3 14581671 (1), 17133500 (1)
    schizophrenia 46.4 14 11304828 (5), 9702739 (2), 16459247 (1), 9686426 (1) (see all 9)
    blepharospasm 39.7 2 11781417 (1), 17133500 (1)
    bipolar disorder 37.2 6 11304828 (3), 10578238 (1), 9702739 (1), 9774780 (1)
    substance dependence 36.3 3 9583233 (1), 11054773 (1)
    conduct disorder 36 1 17579368 (1)
    genetic susceptibility 27.7 3 9034008 (1), 19772578 (1)
    psychiatric disorder 26.1 3 9583233 (1), 11304828 (1)
    migraine 17.3 4 8731424 (2), 12967601 (1), 19772578 (1)

    Genetic Association Database (GAD): DRD5
    Human Genome Epidemiology (HuGE) Navigator: DRD5 (54 documents)

    Export disorders for DRD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DRD5 gene, integrated from 9 sources (see all 212):
    (articles sorted by number of sources associating them with DRD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. (PubMed id 11781417)1, 2, 4, 9 Misbahuddin A....Warner T.T. (2002)
    2. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. (PubMed id 7633397)1, 2, 4, 9 Sobell J.L.... Sommer S.S. (1995)
    3. Role of the dopamine D5 receptor (DRD5) as a susceptibility gene for cervical dystonia. (PubMed id 12700316)1, 4, 9 Brancati F....Dallapiccola B. (2003)
    4. An association study of DRD5 with smoking initiation and progression to nicotine dependence. (PubMed id 11353446)1, 4, 9 Sullivan P.F....Straub R.E. (2001)
    5. Candidate gene studies in focal dystonia. (PubMed id 14581671)1, 4, 9 Sibbing D....Bandmann O. (2003)
    6. Antisociality, substance dependence, and the DRD5 gene: a preliminary study. (PubMed id 11054773)1, 4, 9 Vanyukov M.M....Tarter R.E. (2000)
    7. The human D5 dopamine receptor (DRD5) maps on chromosome 4. (PubMed id 1774076)1, 3, 9 Polymeropoulos M.H....Merril C.R. (1991)
    8. Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. (PubMed id 17501935)1, 4, 9 Lasky-Su J....Faraone S.V. (2007)
    9. Dopamine receptor gene polymorphisms in Guangzhou Hans. (PubMed id 11024217)1, 4, 9 Wang J....Zhu Y. (2000)
    10. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. (PubMed id 1826762)1, 2, 9 Sunahara R.K.... Niznik H.B. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1816 HGNC: 3026 AceView: DRD5 Ensembl:ENSG00000169676 euGenes: HUgn1816
    ECgene: DRD5 Kegg: 1816 H-InvDB: DRD5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DRD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DRD5 gene:
    Search GeneIP for patents involving DRD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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