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Aliases for DRD4 Gene

Aliases for DRD4 Gene

  • Dopamine Receptor D4 2 3
  • D(2C) Dopamine Receptor 3 4
  • Dopamine D4 Receptor 3 4
  • Seven Transmembrane Helix Receptor 3
  • D4DR 3

External Ids for DRD4 Gene

Previous GeneCards Identifiers for DRD4 Gene

  • GC11P001092
  • GC11M000923
  • GC11M000559
  • GC11P000627
  • GC11P000452
  • GC11P000638
  • GC11P000646
  • GC11P000653
  • GC11P000656
  • GC11P000644

Summaries for DRD4 Gene

Entrez Gene Summary for DRD4 Gene

  • This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD4 Gene

DRD4 (Dopamine Receptor D4) is a Protein Coding gene. Diseases associated with DRD4 include attention deficit-hyperactivity disorder and conduct disorder. Among its related pathways are Signaling by GPCR and Circadian entrainment. GO annotations related to this gene include G-protein coupled receptor activity and SH3 domain binding. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for DRD4 Gene

  • Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

Tocris Summary for DRD4 Gene

  • D4 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D3 and D5. They are located primarily in the frontal cortex, midbrain, amygdala and the cardiovascular system. A role in cognition and emotion has been proposed.

Gene Wiki entry for DRD4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD4 Gene

Genomics for DRD4 Gene

Regulatory Elements for DRD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DRD4 Gene

Chromosome:
11
Start:
637,293 bp from pter
End:
640,706 bp from pter
Size:
3,414 bases
Orientation:
Plus strand

Genomic View for DRD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD4 Gene

Proteins for DRD4 Gene

  • Protein details for DRD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21917-DRD4_HUMAN
    Recommended name:
    D(4) dopamine receptor
    Protein Accession:
    P21917
    Secondary Accessions:
    • B0M0J7
    • Q7Z7Q5
    • Q8NGM5

    Protein attributes for DRD4 Gene

    Size:
    467 amino acids
    Molecular mass:
    48361 Da
    Quaternary structure:
    • Forms homo- and heterooligomers with DRD2. D4.7 allele exhibits higher affinity for homodimers compared to DRD2 heterodimers, while alleles D42. and 4.4 have similar affinities for both. The interaction with DRD2 may modulate agonist-induced downstream signaling. Interacts with CLIC6 (By similarity) and GPRASP1. May interact with ADORA2A. Interacts with KLHL12.
    SequenceCaution:
    • Sequence=AAL58637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DRD4 Gene

Proteomics data for DRD4 Gene at MOPED

Post-translational modifications for DRD4 Gene

  • Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein.
  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DRD4 Gene

Domains & Families for DRD4 Gene

Gene Families for DRD4 Gene

Graphical View of Domain Structure for InterPro Entry

P21917

UniProtKB/Swiss-Prot:

DRD4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD4: view

Function for DRD4 Gene

Molecular function for DRD4 Gene

GENATLAS Biochemistry:
dopamine receptor D4,with high affinity for antagonist clozapine,G protein coupled receptor superfamily,not imprinted in the human brain (putatively involved in the susceptibility to Gilles de la Tourette syndrome),and a wide range of neuropsychiatric disorders and normal behavioural variation
UniProtKB/Swiss-Prot Function:
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

Gene Ontology (GO) - Molecular Function for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS --
GO:0004930 G-protein coupled receptor activity --
GO:0004952 dopamine neurotransmitter receptor activity IDA 8413587
GO:0005515 protein binding IPI 12297500
GO:0008144 drug binding IDA 1319557
genes like me logo Genes that share ontologies with DRD4: view
genes like me logo Genes that share phenotypes with DRD4: view

Animal Models for DRD4 Gene

MGI Knock Outs for DRD4:

Animal Model Products

miRNA for DRD4 Gene

miRTarBase miRNAs that target DRD4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRD4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DRD4 Gene

Localization for DRD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD4 Gene COMPARTMENTS Subcellular localization image for DRD4 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 8413587
GO:0005938 cell cortex IEA --
GO:0012506 vesicle membrane IEA --
genes like me logo Genes that share ontologies with DRD4: view

Pathways & Interactions for DRD4 Gene

genes like me logo Genes that share pathways with DRD4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 9843378
GO:0001662 behavioral fear response NAS 12860355
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0001975 response to amphetamine ISS --
GO:0006874 cellular calcium ion homeostasis IC 7921596
genes like me logo Genes that share ontologies with DRD4: view

No data available for SIGNOR curated interactions for DRD4 Gene

Drugs & Compounds for DRD4 Gene

(109) Drugs for DRD4 Gene - From: DGIdb, IUPHAR, NovoSeek, ClinicalTrials, ApexBio, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist, agonist, Target 2814
Apomorphine Approved, Investigational Pharma Activation, Activator, agonist, Target 32
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication 108
Pramipexole Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Dopamine agonist 135
Bromocriptine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target, antagonist 27

(30) Additional Compounds for DRD4 Gene - From: NovoSeek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SKF-82526
Full agonist, Agonist
Promazine 5-sulfoxide
A 412997 dihydrochloride
1347744-96-0
ABT 724 trihydrochloride
587870-77-7
PD 168077 maleate
630117-19-0
genes like me logo Genes that share compounds with DRD4: view

Drug Products

Transcripts for DRD4 Gene

mRNA/cDNA for DRD4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD4 Gene

Dopamine receptor D4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRD4 Gene

No ASD Table

Relevant External Links for DRD4 Gene

GeneLoc Exon Structure for
DRD4
ECgene alternative splicing isoforms for
DRD4

Expression for DRD4 Gene

mRNA expression in normal human tissues for DRD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DRD4 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DRD4 Gene



SOURCE GeneReport for Unigene cluster for DRD4 Gene Hs.99922

genes like me logo Genes that share expression patterns with DRD4: view

Protein tissue co-expression partners for DRD4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DRD4 Gene

Orthologs for DRD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Drd4 35
  • 82.34 (n)
  • 79.32 (a)
Drd4 16
Drd4 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd4 35
  • 81.77 (n)
  • 78.35 (a)
oppossum
(Monodelphis domestica)
Mammalia DRD4 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DRD4 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRD4 35
  • 66.38 (n)
  • 60.98 (a)
DRD4 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD4 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drd4 35
  • 66.67 (n)
  • 69.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6249 35
zebrafish
(Danio rerio)
Actinopterygii drd4a 35
  • 61.93 (n)
  • 59.71 (a)
drd4-rs 36
  • 50 (a)
OneToMany
drd4a 36
  • 51 (a)
OneToMany
drd4b 36
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDOP3 35
  • 51.62 (n)
  • 48.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta D2R 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-2 36
  • 15 (a)
ManyToMany
dop-3 36
  • 20 (a)
ManyToMany
Species with no ortholog for DRD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD4 Gene

ENSEMBL:
Gene Tree for DRD4 (if available)
TreeFam:
Gene Tree for DRD4 (if available)

Paralogs for DRD4 Gene

Paralogs for DRD4 Gene

genes like me logo Genes that share paralogs with DRD4: view

Variants for DRD4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DRD4 Gene

P21917-DRD4_HUMAN
The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction

Sequence variations from dbSNP and Humsavar for DRD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs936463 -- 640,432(+) TTCTT(C/T)GTGGT reference, synonymous-codon
rs1800443 Benign, Benign, - 639,830(+) CGTGG(G/T)CTACT missense, reference
rs2396543 -- 636,703(-) ccccc(A/C)cgcag upstream-variant-2KB
rs7124601 -- 639,273(-) CCCAC(G/T)CAGAT intron-variant
rs10902180 -- 636,706(+) GCTGG(C/G)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DRD4 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
nsv896545 CNV Loss 21882294
dgv935n71 CNV Loss 21882294
dgv936n71 CNV Loss 21882294
nsv467635 CNV Loss 19166990
dgv940n71 CNV Loss 21882294
dgv941n71 CNV Loss 21882294
nsv896570 CNV Loss 21882294
dgv942n71 CNV Loss 21882294
nsv832043 CNV Loss 17160897
esv2743857 CNV Deletion 23290073

Variation tolerance for DRD4 Gene

Gene Damage Index Score: 6.52; 77.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRD4 Gene

HapMap Linkage Disequilibrium report
DRD4
Human Gene Mutation Database (HGMD)
DRD4

Disorders for DRD4 Gene

MalaCards: The human disease database

(25) MalaCards diseases for DRD4 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

- elite association
Search DRD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DRD4

Genetic Association Database (GAD)
DRD4
Human Genome Epidemiology (HuGE) Navigator
DRD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRD4
genes like me logo Genes that share disorders with DRD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRD4 Gene

Publications for DRD4 Gene

  1. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. (PMID: 9015795) Seeman P. … Van Tol H.H. (Neuropsychopharmacology 1997) 23 25 26 67
  2. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. (PMID: 16135699) Burstein E.S. … Brann M.R. (J. Pharmacol. Exp. Ther. 2005) 23 25 67
  3. The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. (PMID: 17301410) Ostadali M.R. … Boulhari J. (Iran J Allergy Asthma Immunol 2004) 25 26 67
  4. Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis. (PMID: 13129658) Glatt S.J. … Tsuang M.T. (Biol. Psychiatry 2003) 23 25 67
  5. Dopamine receptor D4 polymorphism predicts the effect of L-DOPA on gambling behavior. (PMID: 19914604) Eisenegger C. … Fehr E. (Biol. Psychiatry 2010) 23 67

Products for DRD4 Gene

  • Addgene plasmids for DRD4

Sources for DRD4 Gene

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