Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DRD4 Gene

Aliases for DRD4 Gene

  • Dopamine Receptor D4 2 3
  • D(2C) Dopamine Receptor 3 4
  • Dopamine D4 Receptor 3 4
  • Seven Transmembrane Helix Receptor 3
  • D(4) Dopamine Receptor 3
  • D4DR 3

External Ids for DRD4 Gene

Summaries for DRD4 Gene

Entrez Gene Summary for DRD4 Gene

  • This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD4 Gene

DRD4 (Dopamine Receptor D4) is a Protein Coding gene. Diseases associated with DRD4 include separation anxiety disorder and chronic tic disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include identical protein binding and drug binding. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for DRD4 Gene

  • Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

Tocris Summary for DRD4 Gene

  • D4 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D3 and D5. They are located primarily in the frontal cortex, midbrain, amygdala and the cardiovascular system. The function of the D4 receptor is unknown, although a role in cognition and emotion has been proposed. The human D4 receptor gene has been localized to chromosome 11 (11q15.5).

Gene Wiki entry for DRD4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD4 Gene

Genomics for DRD4 Gene

Genomic Location for DRD4 Gene

Start:
637,293 bp from pter
End:
640,706 bp from pter
Size:
3,414 bases
Orientation:
Plus strand

Genomic View for DRD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD4 Gene

Regulatory Elements for DRD4 Gene

Proteins for DRD4 Gene

  • Protein details for DRD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21917-DRD4_HUMAN
    Recommended name:
    D(4) dopamine receptor
    Protein Accession:
    P21917
    Secondary Accessions:
    • B0M0J7
    • Q7Z7Q5
    • Q8NGM5

    Protein attributes for DRD4 Gene

    Size:
    467 amino acids
    Molecular mass:
    48361 Da
    Quaternary structure:
    • Forms homo- and heterooligomers with DRD2. D4.7 allele exhibits higher affinity for homodimers compared to DRD2 heterodimers, while alleles D42. and 4.4 have similar affinities for both. The interaction with DRD2 may modulate agonist-induced downstream signaling. Interacts with CLIC6 (By similarity) and GPRASP1. May interact with ADORA2A. Interacts with KLHL12.
    SequenceCaution:
    • Sequence=AAL58637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DRD4 Gene

Proteomics data for DRD4 Gene at MOPED

Post-translational modifications for DRD4 Gene

  • Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn3

Other Protein References for DRD4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DRD4 Gene

Domains for DRD4 Gene

Gene Families for DRD4 Gene

HGNC:
  • DRD :GPCR / Class A : Dopamine receptors
IUPHAR :

UniProtKB/Swiss-Prot:

DRD4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P21917
genes like me logo Genes that share domains with DRD4: view

Function for DRD4 Gene

Molecular function for DRD4 Gene

GENATLAS Biochemistry: dopamine receptor D4,with high affinity for antagonist clozapine,G protein coupled receptor superfamily,not imprinted in the human brain (putatively involved in the susceptibility to Gilles de la Tourette syndrome),and a wide range of neuropsychiatric disorders and normal behavioural variation
UniProtKB/Swiss-Prot Function: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

Gene Ontology (GO) - Molecular Function for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS --
GO:0004930 G-protein coupled receptor activity --
GO:0004952 dopamine neurotransmitter receptor activity IDA 8413587
GO:0005515 protein binding IPI 12297500
GO:0008144 drug binding IDA 1319557
genes like me logo Genes that share ontologies with DRD4: view
genes like me logo Genes that share phenotypes with DRD4: view

Animal Models for DRD4 Gene

MGI Knock Outs for DRD4:

miRNA for DRD4 Gene

miRTarBase miRNAs that target DRD4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DRD4 Gene

Localization for DRD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD4 Gene COMPARTMENTS Subcellular localization image for DRD4 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 15755724
GO:0005938 cell cortex IEA --
GO:0012506 vesicle membrane IEA --
genes like me logo Genes that share ontologies with DRD4: view

Pathways for DRD4 Gene

genes like me logo Genes that share pathways with DRD4: view

Gene Ontology (GO) - Biological Process for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 15755724
GO:0001662 behavioral fear response NAS 12860355
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0001975 response to amphetamine ISS --
GO:0006874 cellular calcium ion homeostasis IC 7921596
genes like me logo Genes that share ontologies with DRD4: view

Compounds for DRD4 Gene

(5) Tocris Compounds for DRD4 Gene

Compound Action Cas Number
A 412997 dihydrochloride Selective D4 agonist [1347744-96-0]
L-741,742 hydrochloride Highly selective D4 antagonist [156337-32-5]
L-745,870 trihydrochloride Highly selective D4 antagonist [158985-00-3]
PD 168077 maleate High affinity, selective D4 agonist [630117-19-0]
PNU 96415E D4 and 5-HT2A antagonist; antipsychotic [170856-41-4]

(2) HMDB Compounds for DRD4 Gene

Compound Synonyms Cas Number PubMed IDs
Dopamine
  • 2-(3,4-Dihydroxyphenyl)ethylamine
62-31-7
Olanzapine
  • Lanzac
132539-06-1

(24) Drugbank Compounds for DRD4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist partial agonist
Asenapine
65576-45-6 target antagonist
Bromocriptine
  • Bromergocryptine
25614-03-3 target antagonist
Cabergoline
  • Cabergolina [Spanish]
81409-90-7 target agonist

(26) IUPHAR Ligand for DRD4 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]L750667 Antagonist Antagonist 9.8
[3H]spiperone Antagonist Antagonist 9.5
L745870 Antagonist Antagonist 9.4
nemonapride Antagonist Antagonist 9.3
eticlopride Antagonist Antagonist 9.2
U101958 Antagonist Antagonist 8.9
terguride Antagonist Antagonist 8.9
roxindole Antagonist Antagonist 8.6
L741742 Antagonist Antagonist 8.5
(+)-butaclamol Antagonist Antagonist 8.5
[3H]NGD941 Antagonist Antagonist 8.3
(+)-sulpiride Antagonist Antagonist 8.22
(-)-sulpiride Antagonist Antagonist 8
SKF-82526 Agonist Full agonist 7.9
quinpirole Agonist Full agonist 7.7
lisuride Agonist Partial agonist 7.2
piribedil Agonist Partial agonist 6.9
spiperone Antagonist Antagonist 6.7
clozapine Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
pergolide Agonist Full agonist 6.5
bromocriptine Agonist Partial agonist 6.2
haloperidol Antagonist Antagonist 6.1
dopamine Agonist Full agonist 5.6
apomorphine Activator Activation 5.1
chlorpromazine Channel blocker None

(56) Novoseek inferred chemical compound relationships for DRD4 Gene

Compound -log(P) Hits PubMed IDs
dopamine 87.9 140
maoa 78.3 20
clozapine 75.9 46
fananserin 67.5 3
raclopride 62.9 2
genes like me logo Genes that share compounds with DRD4: view

Transcripts for DRD4 Gene

mRNA/cDNA for DRD4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD4 Gene

Dopamine receptor D4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRD4 Gene

No ASD Table

Relevant External Links for DRD4 Gene

GeneLoc Exon Structure for
DRD4
ECgene alternative splicing isoforms for
DRD4

Expression for DRD4 Gene

mRNA expression in normal human tissues for DRD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DRD4 Gene

SOURCE GeneReport for Unigene cluster for DRD4 Gene Hs.99922

genes like me logo Genes that share expressions with DRD4: view

Orthologs for DRD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD4 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd4 36
  • 82.34 (n)
  • 79.32 (a)
Drd4 16
Drd4 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRD4 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd4 36
  • 81.77 (n)
  • 78.35 (a)
chicken
(Gallus gallus)
Aves DRD4 36
  • 66.38 (n)
  • 60.98 (a)
DRD4 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD4 37
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6249 36
tropical clawed frog
(Silurana tropicalis)
Amphibia drd4 36
  • 66.67 (n)
  • 69.4 (a)
zebrafish
(Danio rerio)
Actinopterygii drd4-rs 37
  • 50 (a)
OneToMany
drd4a 36
  • 61.93 (n)
  • 59.71 (a)
drd4a 37
  • 51 (a)
OneToMany
drd4b 37
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDOP3 36
  • 51.62 (n)
  • 48.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta D2R 37
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-2 37
  • 15 (a)
ManyToMany
dop-3 37
  • 20 (a)
ManyToMany
Species with no ortholog for DRD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD4 Gene

ENSEMBL:
Gene Tree for DRD4 (if available)
TreeFam:
Gene Tree for DRD4 (if available)

Paralogs for DRD4 Gene

Paralogs for DRD4 Gene

genes like me logo Genes that share paralogs with DRD4: view

Variants for DRD4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DRD4 Gene

P21917-DRD4_HUMAN
The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction

Sequence variations from dbSNP and Humsavar for DRD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs747302 -- 636,689(+) CTGAG(A/C/G)GCCAG upstream-variant-2KB
rs747303 -- 636,702(+) GCTGC(G/T)GGGGG upstream-variant-2KB
rs752306 -- 637,622(-) AGCAG(A/G)TGAGG intron-variant
rs762502 -- 640,119(+) CCCTG(C/T)GGCCC reference, synonymous-codon
rs916455 -- 636,929(+) GCACG(C/T)ACGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DRD4 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
nsv896545 CNV Loss 21882294
dgv935n71 CNV Loss 21882294
dgv936n71 CNV Loss 21882294
nsv467635 CNV Loss 19166990
dgv940n71 CNV Loss 21882294
dgv941n71 CNV Loss 21882294
nsv896570 CNV Loss 21882294
dgv942n71 CNV Loss 21882294
nsv832043 CNV Loss 17160897
esv2743857 CNV Deletion 23290073

Relevant External Links for DRD4 Gene

HapMap Linkage Disequilibrium report
DRD4
Human Gene Mutation Database (HGMD)
DRD4

Disorders for DRD4 Gene

(2) OMIM Diseases for DRD4 Gene (126452)

(36) Novoseek inferred disease relationships for DRD4 Gene

Disease -log(P) Hits PubMed IDs
novelty seeking personality trait 88.4 6
attention-deficit hyperactivity disorder 88.3 76
schizophrenia 68 102
psychotic 52.5 29
bipolar disorder 51.2 14

Relevant External Links for DRD4

Genetic Association Database (GAD)
DRD4
Human Genome Epidemiology (HuGE) Navigator
DRD4
genes like me logo Genes that share disorders with DRD4: view

No data available for UniProtKB/Swiss-Prot for DRD4 Gene

Publications for DRD4 Gene

  1. Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis. (PMID: 13129658) Glatt S.J. … Tsuang M.T. (Biol. Psychiatry 2003) 3 23 25 49
  2. Dopamine D4 receptor variant, D4-glycine-194, in Africans, but not in Caucasians: no association with schizophrenia. (PMID: 7726213) Seeman P. … Seeman M.V. (Am. J. Med. Genet. 1994) 3 4 23
  3. No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses. (PMID: 10050966) Serretti A. … Smeraldi E. (Am. J. Med. Genet. 1999) 3 23 49
  4. Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects. (PMID: 11054768) Li T. … Collier D.A. (Am. J. Med. Genet. 2000) 3 23 49
  5. Long forms of the dopamine receptor (DRD4) gene VNTR are more prevalent in substance abusers: no interaction with functional alleles of the catechol-o-methyltransferase (COMT) gene. (PMID: 11054777) Vandenbergh D.J. … Uhl G.R. (Am. J. Med. Genet. 2000) 3 23 49

Products for DRD4 Gene

  • Addgene plasmids for DRD4

Sources for DRD4 Gene

Back to Top

Content