DRD3 Gene
protein-coding GIFtS: 68
GCID: GC03M113847
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|
dopamine receptor D3
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Aliases
for DRD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dopamine Receptor D31 2 | | D3DR2 | | Dopamine D3 Receptor2 3 | | D(3) Dopamine Receptor2 | | ETM12 5 | | Essential Tremor 12 | | FET12 5 | | |
Export aliases for DRD3 gene to outside databasesPrevious GC identifers: GC03M110629 GC03M113418 GC03M115128 GC03M115168 GC03M115330 GC03M111221 |
Summaries
for DRD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DRD3:
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor ismediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain,which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may beassociated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results intranscript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay(NMD). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cellproliferation
 summary
for DRD3: D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1,
D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja
where they are involved in the modulation of locomotion and have a possible role in cognition and emotion.
The human D3 receptor gene has been localized to chromosome 3 (3q13.3).
Gene Wiki entry for DRD3 (Dopamine receptor D3)
|
Genomic Views
for DRD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DRD3 gene promoter:
POU2F1 POU2F1a POU3F1 HOXA5 NRSF form 1 POU3F2 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DRD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.3 Ensembl cytogenetic band: 3q13.31 HGNC cytogenetic band: 3q13.3DRD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M113847: view genomic region
(about GC identifiers)
Start:
|
113,847,499 bp from pter |
End:
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113,918,254 bp from pter |
Size:
|
70,756 bases |
Orientation:
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minus strand |
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Proteins
for DRD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462 (See
protein sequence)Recommended Name: D(3) dopamine receptor Size: 400 amino acids; 44225 Da
Subunit: Interacts with CLIC6 (By similarity). Interacts with GRK4. Interacts with PALM
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in thecytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of thereceptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells
Sequence caution: Sequence=AAA03543.1; Type=Frameshift; Positions=288; Sequence=AAA64369.1; Type=Erroneous gene modelprediction;
1 PDB 3D structure from  and Proteopedia  for DRD3:3PBL (3D)
Secondary accessions: A1A4V5 Q4VBM8Alternative splicing: 2 isoforms: P35462-1 P35462-3 Explore the universe of human proteins at neXtProt for DRD3: NX_P35462
Post-translational modifications:
Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35462
DRD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000787.2 NP_387512.3
ENSEMBL proteins: ENSP00000419402 ENSP00000420662 ENSP00000295881 ENSP00000373169 Reactome Protein details: P35462
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
DRD3 for ontologies About GeneDecksing
DRD3 Antibody Products:
Assay Products for DRD3: |
Protein
Domains /
Families
for DRD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DRD3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35462ProtoNet protein and cluster: P35462 2 Blocks protein families: IPB000929 Dopamine receptor signature IPB001620 Dopamine D3 receptor signature
UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for DRD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cellproliferation Genatlas biochemistry entry for DRD3:dopamine receptor D3,adenylate cyclase inhibiting,G protein coupled receptor superfamily (no evidence for associationof sequence variants and bipolar disorder),or attention-deficit hyperactivity disorder,some evidence for associationwith schizophrenia,at least in Caucasians
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DRD3 (NM_000796) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DRD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD3 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
DRD3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DRD3:
Animal Models:
Mouse knock-outs for DRD3: Drd3tm1Schm Drd3tm1Rmw Drd3tm1Dac Drd3tm1Stl
9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Drd3):
DRD3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DRD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Monoamine GPCRs | | | 4 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | | | 5 | Dopamine receptors | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DRD3
4  BioSystems Pathways for DRD3
5/8 
Reactome Pathways for DRD3 (see all 8)
1  PharmGKB Pathway for DRD3
1 
Kegg Pathway (Kegg details for DRD3):
DRD3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DRD3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/160 Interacting proteins for DRD3 (P354623 ENSP000003731694) via UniProtKB, MINT, STRING, and/or I2D (see all 160)About this table
Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0001963 | synaptic transmission, dopaminergic |
IEA | -- | | GO:0001975 | response to amphetamine |
IEA | -- | | GO:0002016 | regulation of blood volume by renin-angiotensin |
IEA | -- | | GO:0002031 | G-protein coupled receptor internalization |
IDA | 18424554 |
DRD3 for ontologies About GeneDecksing
|
Drugs & Compounds
for DRD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DRD3 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for DRD3 |
Compounds for DRD3 available from Tocris Bioscience About this table
2 HMDB Compounds for DRD3 About this table
10/26 DrugBank Compounds for DRD3 (see all 26) About this table
10/52 Novoseek chemical compound relationships for DRD3 gene (see all 52) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dopamine |
86.3 |
228 |
7493610 (3), 10578238 (2), 8813541 (2), 14681904 (2) (see all 99) |
| nafadotride |
82.3 |
9 |
8531087 (3), 11334239 (2), 16793583 (1) |
| pramipexole |
81.7 |
16 |
8891576 (2), 10082211 (1), 11054155 (1), 19412489 (1) (see all 15) |
| pd 128907 |
81.2 |
3 |
10728880 (2), 9371544 (1) |
| quinpirole |
78.5 |
4 |
7904244 (1), 7915820 (1), 15689168 (1), 7498261 (1) |
| arylamide |
71.1 |
1 |
19924694 (1) |
| pergolide |
64.3 |
3 |
10082211 (1), 11261747 (1), 12539211 (1) |
| amisulpride |
63.2 |
5 |
12165366 (1), 9165379 (1), 10200742 (1), 7802104 (1) (see all 5) |
| apomorphine |
58.9 |
3 |
9353400 (2), 7904244 (1) |
| haloperidol |
57.8 |
4 |
15584906 (1), 8313980 (1), 8996810 (1), 9421827 (1) |
5 PharmGKB related drug/compound annotations for DRD3 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about DRD3
|
Transcripts
for DRD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DRD3 gene (5 alternative transcripts): NM_000796.3 NM_033663.3 NM_033658.1 NM_033659.1 NM_033660.1 Unigene Cluster for DRD3: Dopamine receptor D3 Hs.121478 [show with all ESTs]Unigene Representative Sequence: NM_0007964 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460779(uc010hqn.1) ENST00000467632(uc003ebd.2) ENST00000295881
ENST00000383673(uc003ebb.1 uc003ebc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DRD3 (NM_000796) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DRD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD3 |
Additional cDNA sequence: AK292309.1 AY228454.1 AY228455.1 AY228456.1 AY228457.1 AY228458.1 AY228459.1 BC095510.1 BC128122.1 BC128123.1 L20469.1 U32499.1 2 DOTS entries: DT.104818 DT.92414650 23 AceView cDNA sequences: AY228456 AY228459 AY228458 BC069132 NM_000796 AY228454 CN843313 NM_033660 NM_033658 NM_033663 NM_033659 CN831709 CN843849 U32499 AY228457 L20469 CN843052 CN843985 CN841983 AY228455 CN831545 CN843649 CN843233
GeneLoc Exon Structure
|
Expression
for DRD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DRD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGGCTAC
About this image
See DRD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DRD3
SOURCE GeneReport for Unigene cluster: Hs.121478
UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462Tissue specificity: Brain
SABiosciences Expression via Pathway-Focused PCR Arrays including DRD3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DRD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DRD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD3 |
Orthologs
for DRD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DRD3 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for DRD3 (if available)
TreeFam Gene Tree for DRD3 (if available) |
Paralogs
for DRD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DRD3 gene
- DRD42 HTR1A2 ADRA1B2 DRD22 HTR1F2 HTR72 ADRA2C2 ADRA2A2
- HTR1D2 ADRA2B2 ADRA1A2 HTR1E2 HTR5A2 HTR1B2 ADRA1D2
18/36 SIMAP similar genes for DRD3 using alignment to 6 protein entries: DRD3_HUMAN (see all proteins)
(see all similar genes):NPY2R HCRTR2 NPFFR1 ADRA1D DRD2 GPR19
GPR83 ADORA2B dopamine D4 receptor hA2aR HTR2A NMUR1
dopamine D4 receptor/ DRD4 alpha 1c-adrenoceptor subtype HRH3 HTR2C 5HT1A HTR1A
DRD3 for paralogs About GeneDecksing
|
Genomic Variants
for DRD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DRD3 (113847499 - 113918254 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for DRD3
6 Indels: 42231 27136 98409 12322 62088 40555
Human Gene Mutation Database (HGMD): DRD3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DRD3 |
|
Disorders
/ Diseases
for DRD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DRD3 for disorders About GeneDecksing
OMIM gene information: 126451
OMIM disorders: 181500 190300
UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462
Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 isthe most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, andfacial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperatureextremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant
20/59  diseases for DRD3 (see all 59): About MalaCardsessential tremor tremor obsessive-compulsive disorder obsessive-compulsive personality disorder
manic-depressive illness myoclonus-dystonia attention deficit hyperactivity disorder migraine without aura
cocaine dependence substance dependence personality disorder drug dependence
restless legs syndrome pathological gambling alcohol abuse drug addiction
tardive dyskinesia delusional disorder schizoaffective disorder major depressive disorder
7 diseases from the University of Copenhagen DISEASES database for DRD3:Schizophrenia Essential tremor Substance dependence Parkinson's disease
lingual-facial-buccal dyskinesia Substance abuse Pathological gambling 10/33 Novoseek disease relationships for DRD3 gene (see all 33) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
76.4 |
159 |
19897343 (6), 9674978 (5), 11104840 (4), 18449897 (4) (see all 72) |
| parkinson disease |
56.6 |
13 |
8891576 (2), 19371585 (2), 17174156 (2), 19711120 (1) (see all 10) |
| drug addiction |
53.9 |
9 |
10432116 (1), 19128200 (1), 15960988 (1), 17627675 (1) (see all 8) |
| essential tremor |
51.8 |
10 |
18316228 (2), 19645064 (2), 16809426 (1), 19524641 (1) |
| bipolar disorder |
48.9 |
20 |
15539862 (2), 8509522 (2), 11093065 (2), 12834818 (2) (see all 13) |
| cocaine dependence |
44.7 |
12 |
12893467 (4), 10523822 (4), 19503018 (1), 9154209 (1) |
| movement disorders |
44.5 |
4 |
19058789 (1), 10893495 (1), 11179771 (1) |
| drug dependence |
43.3 |
7 |
15963538 (3), 9702742 (2), 17155853 (1) |
| substance dependence |
37 |
2 |
9790747 (1), 11681590 (1) |
| psychotic |
35 |
11 |
11104840 (2), 10490702 (2), 11723200 (2), 9779662 (1) (see all 7) |
Genetic Association Database (GAD): DRD3
Human Genome Epidemiology (HuGE) Navigator: DRD3 (202 documents)
Export disorders for DRD3 gene to outside databases
|
Publications
for DRD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DRD3 gene, integrated from 9 sources (see all 580):
(articles sorted by number of sources associating them with DRD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. (PubMed id 9034004)1, 2, 4, 9 Chen C.-H.... Hsiao K.-J. (1997)
- Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. (PubMed id 14681904)1, 4, 9 Szekeres G....Janka Z. (2004)
- DRD3 and DAT1 genes in schizophrenia: an association study. (PubMed id 11104840)1, 4, 9 Joober R....Rouleau G.A. (2000)
- Ser9Gly polymorphism in the dopamine D3 receptor gene is not associated with essential hypertension in the Japanese. (PubMed id 11796958)1, 4, 9 Soma M....Kanmatsuse K. (2002)
- Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors. (PubMed id 18831971)1, 7, 9 Tadori Y....Kikuchi T. (2008)
- [Correlation between the effectiveness of atypical antipsychotics and dopamine D3 receptor polymorphism in schizophrenia] (PubMed id 12632798)1, 4, 9 Szekeres G....Janka Z. (2002)
- Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. (PubMed id 11920858)1, 4, 9 Li T....Collier D.A. (2002)
- Dopamine D3 receptor (DRD3) gene polymorphism is associated with the intensity of eye movement disturbances in schizophrenic patients and healthy subjects. (PubMed id 11673801)1, 4, 9 Rybakowski J.K....Hauser J. (2001)
- Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population. (PubMed id 15567076)1, 4, 9 Staddon S....Kerwin R.W. (2005)
- Habit learning and the genetics of the dopamine D3 receptor: evidence from patients with schizophrenia and healthy controls. (PubMed id 15998189)1, 4, 9 Keri S....Janka Z. (2005)
|
External Searches for DRD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DRD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DRD3 gene
(According to HUGE)
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Specialized Databases showing DRD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for DRD3 | Pharmacogenomics, SNPs, Pathways | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=DRD3 |
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| Patent Information for DRD3 gene:
Search GeneIP for patents involving DRD3
Licensable Technologies for DRD3 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DRD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DRD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DRD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DRD3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DRD3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DRD3 | | OriGene Custom Protein Services for DRD3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DRD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DRD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DRD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRD3 |
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| | | | Tocris compounds for DRD3 |
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 | | | DRD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD3 |
|  |  |  | | | | Search ThermoFisher Antibodies for DRD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD3 |
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