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Aliases for DRD3 Gene

Aliases for DRD3 Gene

  • Dopamine Receptor D3 2 3
  • ETM1 3 6
  • FET1 3 6
  • D(3) Dopamine Receptor 3
  • Dopamine D3 Receptor 4
  • Essential Tremor 1 3
  • D3DR 3

External Ids for DRD3 Gene

Summaries for DRD3 Gene

Entrez Gene Summary for DRD3 Gene

  • This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD3 Gene

DRD3 (Dopamine Receptor D3) is a Protein Coding gene. Diseases associated with DRD3 include delusional disorder and essential tremor. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein domain specific binding and dopamine binding. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for DRD3 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Tocris Summary for DRD3 Gene

  • D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion and have a possible role in cognition and emotion. The human D3 receptor gene has been localized to chromosome 3 (3q13.3).

Gene Wiki entry for DRD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD3 Gene

Genomics for DRD3 Gene

Genomic Location for DRD3 Gene

Start:
114,128,652 bp from pter
End:
114,199,407 bp from pter
Size:
70,756 bases
Orientation:
Minus strand

Genomic View for DRD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD3 Gene

Regulatory Elements for DRD3 Gene

Proteins for DRD3 Gene

  • Protein details for DRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35462-DRD3_HUMAN
    Recommended name:
    D(3) dopamine receptor
    Protein Accession:
    P35462
    Secondary Accessions:
    • A1A4V5
    • Q4VBM8

    Protein attributes for DRD3 Gene

    Size:
    400 amino acids
    Molecular mass:
    44225 Da
    Quaternary structure:
    • Interacts with CLIC6 (By similarity). Interacts with GRK4. Interacts with PALM.
    SequenceCaution:
    • Sequence=AAA03543.1; Type=Frameshift; Positions=288; Evidence={ECO:0000305}; Sequence=AAA64369.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DRD3 Gene

    Alternative splice isoforms for DRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRD3 Gene

Proteomics data for DRD3 Gene at MOPED

Post-translational modifications for DRD3 Gene

  • Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn12, Asn19, Asn97, and Asn173

Other Protein References for DRD3 Gene

No data available for DME Specific Peptides for DRD3 Gene

Domains for DRD3 Gene

Gene Families for DRD3 Gene

HGNC:
  • DRD :GPCR / Class A : Dopamine receptors
IUPHAR :

UniProtKB/Swiss-Prot:

DRD3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P35462
genes like me logo Genes that share domains with DRD3: view

Function for DRD3 Gene

Molecular function for DRD3 Gene

GENATLAS Biochemistry: dopamine receptor D3,adenylate cyclase inhibiting,G protein coupled receptor superfamily (no evidence for association of sequence variants and bipolar disorder),or attention-deficit hyperactivity disorder,some evidence for association with schizophrenia,at least in Caucasians
UniProtKB/Swiss-Prot Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS --
GO:0004930 G-protein coupled receptor activity --
GO:0004952 dopamine neurotransmitter receptor activity --
GO:0005515 protein binding IPI 10692483
GO:0008144 drug binding ISS --
genes like me logo Genes that share ontologies with DRD3: view
genes like me logo Genes that share phenotypes with DRD3: view

Animal Models for DRD3 Gene

MGI Knock Outs for DRD3:

miRNA for DRD3 Gene

miRTarBase miRNAs that target DRD3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DRD3 Gene

Localization for DRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD3 Gene

Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD3 Gene COMPARTMENTS Subcellular localization image for DRD3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 8413587
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030139 endocytic vesicle IEA --
genes like me logo Genes that share ontologies with DRD3: view

Pathways for DRD3 Gene

genes like me logo Genes that share pathways with DRD3: view

Gene Ontology (GO) - Biological Process for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0001975 response to amphetamine IEA --
GO:0002016 regulation of blood volume by renin-angiotensin IEA --
GO:0002031 G-protein coupled receptor internalization IDA 18424554
genes like me logo Genes that share ontologies with DRD3: view

Compounds for DRD3 Gene

(5) Tocris Compounds for DRD3 Gene

Compound Action Cas Number
(+)-PD 128907 hydrochloride D3 agonist (D3 = D2 > D4) [300576-59-4]
Nafadotride Highly potent, preferential D3 antagonist [149649-22-9]
PG 01037 dihydrochloride D3 receptor selective antagonist [675599-62-9]
Pramipexole dihydrochloride Selective D3 agonist [104632-25-9]
SB 277011A dihydrochloride Selective D3 antagonist [1226917-67-4]

(2) HMDB Compounds for DRD3 Gene

Compound Synonyms Cas Number PubMed IDs
Dopamine
  • 2-(3,4-Dihydroxyphenyl)ethylamine
62-31-7
Olanzapine
  • Lanzac
132539-06-1

(28) Drugbank Compounds for DRD3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amisulpride
53583-79-2 target antagonist
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist partial agonist
Asenapine
65576-45-6 target antagonist
Bromocriptine
  • Bromergocryptine
25614-03-3 target agonist

(41) IUPHAR Ligand for DRD3 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]nemonapride Antagonist Antagonist 10.9
S33084 Antagonist Antagonist 9.6
[3H]7-OH-DPAT Agonist Agonist 9.6
nemonapride Antagonist Antagonist 9.3
eticlopride Antagonist Antagonist 9.2
[3H]PD128907 Agonist Agonist 9
terguride Antagonist Antagonist 8.9
(-)-N-porphynorapomorphine Agonist Full agonist 8.9
roxindole Antagonist Antagonist 8.6
nafadotride Antagonist Antagonist 8.5
(+)-butaclamol Antagonist Antagonist 8.5
cis flupentixol Antagonist Antagonist 8.4
domperidone Antagonist Antagonist 8.4
(+)-sulpiride Antagonist Antagonist 8.22
SB 277011-A Antagonist Antagonist 8
raclopride Antagonist Antagonist 8
(-)-sulpiride Antagonist Antagonist 8
sulpiride Antagonist Antagonist 7.92
risperidone Antagonist Antagonist 7.8
quinpirole Agonist Full agonist 7.7
7-OH-DPAT Agonist Full agonist 7.6
pramipexole Agonist Full agonist 7.4
lisuride Agonist Partial agonist 7.2
(+)-UH232 Antagonist Antagonist 7.1
piribedil Agonist Partial agonist 6.9
spiperone Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
clozapine Antagonist Antagonist 6.7
pergolide Agonist Full agonist 6.5
PD 128907 Agonist Full agonist 6.4
pimozide Antagonist Antagonist 6.2
bromocriptine Agonist Partial agonist 6.2
(+)-AJ76 Antagonist Antagonist 6.2
haloperidol Antagonist Antagonist 6.1
trans flupenthixol Antagonist Antagonist 6
quinelorane Agonist Full agonist 5.7
7-trans-OH-PIPAT Agonist Full agonist 5.6
dopamine Agonist Full agonist 5.6
(+)-S-14297 Antagonist Antagonist 5.5
apomorphine Activator Activation 5.1
chlorpromazine Channel blocker None

(52) Novoseek inferred chemical compound relationships for DRD3 Gene

Compound -log(P) Hits PubMed IDs
dopamine 86.3 115
nafadotride 82.3 6
pramipexole 81.7 16
pd 128907 81.2 3
quinpirole 78.5 4

(6) PharmGKB related drug/compound annotations for DRD3 Gene

Drug/compound Annotation
clozapine CA
duloxetine CA
olanzapine CA
paroxetine CA
pramipexole CA
risperidone CA
genes like me logo Genes that share compounds with DRD3: view

Transcripts for DRD3 Gene

Unigene Clusters for DRD3 Gene

Dopamine receptor D3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRD3 Gene

No ASD Table

Relevant External Links for DRD3 Gene

GeneLoc Exon Structure for
DRD3
ECgene alternative splicing isoforms for
DRD3

Expression for DRD3 Gene

mRNA expression in normal human tissues for DRD3 Gene

mRNA differential expression in normal tissues according to GTEx for DRD3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (25.6), Brain - Caudate (basal ganglia) (9.2), and Brain - Putamen (basal ganglia) (8.7).

SOURCE GeneReport for Unigene cluster for DRD3 Gene Hs.121478

mRNA Expression by UniProt/SwissProt for DRD3 Gene

P35462-DRD3_HUMAN
Tissue specificity: Brain
genes like me logo Genes that share expressions with DRD3: view

Orthologs for DRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD3 36
  • 99.17 (n)
  • 99.5 (a)
DRD3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRD3 36
  • 89.19 (n)
  • 89.65 (a)
DRD3 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRD3 36
  • 89.67 (n)
  • 93.75 (a)
DRD3 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd3 36
  • 87.13 (n)
  • 90.73 (a)
Drd3 16
Drd3 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRD3 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd3 36
  • 85.71 (n)
  • 89.97 (a)
chicken
(Gallus gallus)
Aves DRD3 36
  • 70.94 (n)
  • 71.28 (a)
DRD3 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD3 37
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 36
drd3 36
  • 63.27 (n)
  • 68.1 (a)
drd3 37
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta D2R 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-2 36
  • 46.84 (n)
  • 39.2 (a)
dop-2 37
  • 16 (a)
ManyToMany
dop-3 37
  • 22 (a)
ManyToMany
C09B7.1b 38
  • 31 (a)
C09B7.1a 38
  • 31 (a)
Species with no ortholog for DRD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DRD3 Gene

ENSEMBL:
Gene Tree for DRD3 (if available)
TreeFam:
Gene Tree for DRD3 (if available)

Paralogs for DRD3 Gene

Paralogs for DRD3 Gene

genes like me logo Genes that share paralogs with DRD3: view

Variants for DRD3 Gene

Sequence variations from dbSNP and Humsavar for DRD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6280 other, - 114,171,968(+) GTGGC(C/T)ACTCA missense, reference
rs167770 -- 114,160,715(+) AGCTT(A/G)GAAAC intron-variant
rs167771 -- 114,157,428(+) ACAAT(A/G)ATCCT intron-variant
rs170482 -- 114,172,822(+) aattt(A/G)ttgtc intron-variant, upstream-variant-2KB
rs188958 -- 114,167,039(-) GATAT(C/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRD3 Gene

Variant ID Type Subtype PubMed ID
nsv877352 CNV Gain 21882294
nsv877353 CNV Gain 21882294
esv259489 OTHER Complex 20981092
esv1358990 CNV Insertion 17803354
esv2537070 CNV Deletion 19546169
esv990133 CNV Deletion 20482838
esv2841 CNV Deletion 18987735
esv2725782 CNV Deletion 23290073
esv1006467 CNV Deletion 20482838
nsv236315 CNV Loss 16902084
dgv25e197 CNV Deletion 19546169
esv9452 CNV Loss 19470904
esv1654104 CNV Deletion 17803354
nsv237833 CNV Loss 16902084

Relevant External Links for DRD3 Gene

HapMap Linkage Disequilibrium report
DRD3
Human Gene Mutation Database (HGMD)
DRD3

Disorders for DRD3 Gene

(2) OMIM Diseases for DRD3 Gene (126451)

UniProtKB/Swiss-Prot

DRD3_HUMAN
  • Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:16650084, ECO:0000269 PubMed:16809426}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(33) Novoseek inferred disease relationships for DRD3 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 76.4 123
parkinson disease 56.6 13
drug addiction 53.9 8
essential tremor 51.8 6
bipolar disorder 48.9 17

Relevant External Links for DRD3

Genetic Association Database (GAD)
DRD3
Human Genome Epidemiology (HuGE) Navigator
DRD3
genes like me logo Genes that share disorders with DRD3: view

Publications for DRD3 Gene

  1. Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. (PMID: 9034004) Chen C.-H. … Hsiao K.-J. (Am. J. Med. Genet. 1997) 3 4 23 49
  2. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. (PMID: 16809426) Jeanneteau F. … Sokoloff P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23 49
  3. Genetic susceptibility to Parkinson's disease among South and North Indians: I. Role of polymorphisms in dopamine receptor and transporter genes and association of DRD4 120-bp duplication marker. (PMID: 16816977) Juyal R.C. … Thelma B.K. (Neurogenetics 2006) 3 23 49
  4. Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression. (PMID: 16583407) Light K.J. … Kennedy M.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 49
  5. No association of dopamine receptor sensitivity in vivo with genetic predisposition for alcoholism and DRD2/DRD3 gene polymorphisms in alcohol dependence. (PMID: 16759339) Wiesbeck G.A. … BAPning J. (Addict Biol 2006) 3 23 49

Products for DRD3 Gene

Sources for DRD3 Gene

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