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DRD3 Gene

protein-coding   GIFtS: 71
GCID: GC03M113847

Dopamine Receptor D3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dopamine Receptor D31 2     D(3) Dopamine Receptor2
ETM12 5     Essential Tremor 12
FET12 5     Dopamine D3 Receptor3
D3DR2     

External Ids:    HGNC: 30241   Entrez Gene: 18142   Ensembl: ENSG000001515777   OMIM: 1264515   UniProtKB: P354623   

Export aliases for DRD3 gene to outside databases

Previous GC identifers: GC03M110629 GC03M113418 GC03M115128 GC03M115168 GC03M115330 GC03M111221


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DRD3 Gene:
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor
is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the
brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene
may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results
in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated
decay (NMD). (provided by RefSeq, Jul 2008)

GeneCards Summary for DRD3 Gene:
DRD3 (dopamine receptor D3) is a protein-coding gene. Diseases associated with DRD3 include tremor, and essential tremor. GO annotations related to this gene include dopamine binding and protein domain specific binding. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462
Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell
proliferation

summary for DRD3 Gene:
D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1,
D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja
where they are involved in the modulation of locomotion and have a possible role in cognition and emotion.
The human D3 receptor gene has been localized to chromosome 3 (3q13.3).

Gene Wiki entry for DRD3 (Dopamine receptor D3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DRD3 gene promoter:
         POU2F1   POU2F1a   POU3F1   HOXA5   NRSF form 1   POU3F2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRD3 promoter sequence
   Search Chromatin IP Primers for DRD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3   Ensembl cytogenetic band:  3q13.31   HGNC cytogenetic band: 3q13.3

DRD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRD3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M113847:  view genomic region     (about GC identifiers)

Start:
113,847,499 bp from pter      End:
113,918,254 bp from pter
Size:
70,756 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462 (See protein sequence)
Recommended Name: D(3) dopamine receptor  
Size: 400 amino acids; 44225 Da
Subunit: Interacts with CLIC6 (By similarity). Interacts with GRK4. Interacts with PALM
Sequence caution: Sequence=AAA03543.1; Type=Frameshift; Positions=288; Sequence=AAA64369.1; Type=Erroneous gene
model prediction;
1 PDB 3D structure from and Proteopedia for DRD3:
3PBL (3D)    
Secondary accessions: A1A4V5 Q4VBM8
Alternative splicing: 2 isoforms:  P35462-1   P35462-3   

Explore the universe of human proteins at neXtProt for DRD3: NX_P35462

Explore proteomics data for DRD3 at MOPED

Post-translational modifications: 

  • Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma)1
  • Glycosylation2 at Asn12, Asn19, Asn97, Asn173
  • Modification sites at PhosphoSitePlus

  • See DRD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000787.2  NP_001269492.1  NP_001277738.1  NP_387512.3  

    ENSEMBL proteins: 
     ENSP00000419402   ENSP00000420662   ENSP00000373169   ENSP00000295881  
    Reactome Protein details: P35462

    DRD3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant DRD3 Protein
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    Browse OriGene Protein Over-expression Lysates
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    Cloud-Clone Corp. Proteins for DRD3

    DRD3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DRD3
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    LSBio Antibodies in human, mouse, rat for DRD3

    DRD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for DRD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DRD: GPCR / Class A : Dopamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: D3 receptor
    Dopamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000929 Dopamine_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001620 Dopamine_D3_rcpt

    Graphical View of Domain Structure for InterPro Entry P35462

    ProtoNet protein and cluster: P35462

    2 Blocks protein domains:
    IPB000929 Dopamine receptor signature
    IPB001620 Dopamine D3 receptor signature


    UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462
    Similarity: Belongs to the G-protein coupled receptor 1 family


    DRD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRD3_HUMAN, P35462
    Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell
    proliferation

         Genatlas biochemistry entry for DRD3:
    dopamine receptor D3,adenylate cyclase inhibiting,G protein coupled receptor superfamily (no evidence for
    association of sequence variants and bipolar disorder),or attention-deficit hyperactivity disorder,some evidence
    for association with schizophrenia,at least in Caucasians

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004952dopamine neurotransmitter receptor activity ----
    GO:0005515protein binding IPI10692483
    GO:0008144drug binding ISS--
         
    DRD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DRD3:
     Decreased DCP1a protein expres 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Drd3):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body 
     homeostasis/metabolism  mortality/aging  nervous system  renal/urinary system 

    DRD3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DRD3: Drd3tm1Schm Drd3tm1Rmw Drd3tm1Dac Drd3tm1Stl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRD3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRD3

    miRNA
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    miRTarBase miRNAs that target DRD3:
    hsa-mir-26b-5p (MIRT029658)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DRD3 (NM_000796)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRD3_HUMAN, P35462: Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the
    cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of
    the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the
    membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA8413587
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030139endocytic vesicle IEA--

    DRD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DRD3 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Dopamine receptors0.00
    Amine ligand-binding receptors0.79
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Circadian entrainment
    Dopaminergic synapse0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DRD3
        CDK5 Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    4 BioSystems Pathways for DRD3
        Nicotine Activity on Dopaminergic Neurons
    GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for DRD3
        Dopamine receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for DRD3
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    2 Kegg Pathways  (Kegg details for DRD3):
        Neuroactive ligand-receptor interaction
    Dopaminergic synapse


    DRD3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DRD3: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DRD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DRD3 (P354623 ENSP000003731694) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPB41L1Q9H4G03, ENSP000003371684I2D: score=3 STRING: ENSP00000337168
    CLIC6Q96NY73, ENSP000002903324I2D: score=2 STRING: ENSP00000290332
    RDXP352413, ENSP000003428304I2D: score=1 STRING: ENSP00000342830
    FLNAP213333, ENSP000003588664I2D: score=4 STRING: ENSP00000358866
    GIPC1O149083, ENSP000003406984I2D: score=4 STRING: ENSP00000340698
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0001975response to amphetamine IEA--
    GO:0002016regulation of blood volume by renin-angiotensin IEA--
    GO:0002031G-protein coupled receptor internalization IDA18424554

    DRD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DRD3
      Browse compounds at ApexBio 

    Compounds for DRD3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Pramipexole dihydrochlorideSelective D3 agonist[104632-25-9]
    (+)-PD 128907 hydrochlorideD3 agonist (D3 = D2 > D4)[300576-59-4]
    PG 01037 dihydrochlorideD3 receptor selective antagonist[675599-62-9]
    SB 277011A dihydrochlorideSelective D3 antagonist[1226917-67-4]
    Nafadotride Highly potent, preferential D3 antagonist [149649-22-9]

    2 HMDB Compounds for DRD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    OlanzapineLanzac (see all 5)132539-06-1--

    Selected DrugBank Compounds for DRD3 (see all 28)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Haloperidol-- 52-86-8targetinverse agonist16123775 18831971 9536001 7520908 19496999
    Amisulpride-- 53583-79-2targetantagonist12404702 16696579 11873706
    Asenapine-- 65576-45-6targetantagonist21655346 21658377 18308814
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist10641988 18691132 18992242
    ChlorprothixeneAlpha-Chlorprothixene (see all 9)113-59-7targetantagonist17139284 17016423 1830565
    Levodopa3,4-dihydroxyphenylalanine (see all 4)59-92-7targetagonist11978145 18549347 9633680
    PergolidePergolida [INN-Spanish] (see all 4)66104-22-1targetagonist1683537 10641988 18691132
    Pramipexole-- 104632-26-0targetagonist11752352 10641988 18691132
    RopiniroleRopinirol [INN-Spanish] (see all 4)91374-21-9targetagonist11752352 10641988 18691132
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist10641988 18691132

    Selected IUPHAR Ligands for DRD3 (D3 receptor) (see all 41)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]nemonapride
    AntagonistAntagonist10.314535946
    S33084
    AntagonistAntagonist9.610869410
    [3H]7-OH-DPAT
    AgonistAgonist9.67759603
    lisuride
    AgonistPartial agonist9.612388666
    nafadotride
    AntagonistAntagonist9.528531087
    nemonapride
    AntagonistAntagonist9.2 - 9.37907989 8301592
    spiperone
    AntagonistAntagonist9.21975644
    cabergoline
    AgonistPartial agonist9.112388666
    [3H]PD128907
    AgonistAgonist97674830
    terguride
    AgonistPartial agonist912388666

    Selected Novoseek inferred chemical compound relationships for DRD3 gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 86.3 228 7493610 (3), 10578238 (2), 8813541 (2), 14681904 (2) (see all 99)
    nafadotride 82.3 9 8531087 (3), 11334239 (2), 16793583 (1)
    pramipexole 81.7 16 8891576 (2), 10082211 (1), 11054155 (1), 19412489 (1) (see all 15)
    pd 128907 81.2 3 10728880 (2), 9371544 (1)
    quinpirole 78.5 4 7904244 (1), 7915820 (1), 15689168 (1), 7498261 (1)
    arylamide 71.1 1 19924694 (1)
    pergolide 64.3 3 10082211 (1), 11261747 (1), 12539211 (1)
    amisulpride 63.2 5 12165366 (1), 9165379 (1), 10200742 (1), 7802104 (1) (see all 5)
    apomorphine 58.9 3 9353400 (2), 7904244 (1)
    haloperidol 57.8 4 15584906 (1), 8313980 (1), 8996810 (1), 9421827 (1)

    6 PharmGKB related drug/compound annotations for DRD3 gene    About this table
    Drug/compound PharmGKB Annotation
    clozapineCA  
    duloxetineCA  
    olanzapineCA  
    paroxetineCA  
    pramipexoleCA  
    risperidoneCA  



    DRD3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DRD3 gene (7 alternative transcripts): 
    NM_000796.5  NM_001282563.2  NM_001290809.1  NM_033663.5  NM_033658.1  NM_033659.1  NM_033660.1  

    Unigene Cluster for DRD3:

    Dopamine receptor D3
    Hs.121478  [show with all ESTs]
    Unigene Representative Sequence: NM_000796
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460779(uc010hqn.1) ENST00000467632(uc003ebd.2) ENST00000383673(uc003ebb.1 uc003ebc.1)
    ENST00000295881

    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DRD3 (NM_000796)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD3
    Primer
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    OriGene qPCR primer pairs and template standards for DRD3
    OriGene qSTAR qPCR primer pairs in human, mouse for DRD3
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      QuantiTect SYBR Green Assays in human, mouse, rat DRD3
      QuantiFast Probe-based Assays in human, mouse, rat DRD3

    Additional mRNA sequence: 

    AK292309.1 AY228454.1 AY228455.1 AY228456.1 AY228457.1 AY228458.1 AY228459.1 BC095510.1 
    BC128122.1 BC128123.1 L20469.1 U32499.1 

    2 DOTS entries:

    DT.104818  DT.92414650 

    23 AceView cDNA sequences:

    AY228459 AY228456 NM_033658 NM_033663 AY228454 U32499 NM_000796 NM_033659 
    CN843849 AY228458 L20469 NM_033660 BC069132 AY228457 CN831709 CN843313 
    CN841983 AY228455 CN843649 CN843052 CN843985 CN831545 CN843233 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DRD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGGCTAC
    DRD3 Expression
    About this image


    DRD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
    DRD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121478

    UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462
    Tissue specificity: Brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DRD3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DRD3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drd31 , 5 dopamine receptor D31, 5 87.13(n)1
    90.73(a)1
      16 (28.44 cM)5
    134901  NM_007877.11  NP_031903.11 
     437622425 
    chicken
    (Gallus gallus)
    Aves DRD31 dopamine receptor D3 70.94(n)
    71.28(a)
      770757  XM_004938205.1  XP_004938262.1 
    lizard
    (Anolis carolinensis)
    Reptilia DRD36
    dopamine receptor D3
    65(a)
    1 ↔ 1
    3(176551888-176591711)
    zebrafish
    (Danio rerio)
    Actinopterygii AY183455.12   -- 76.59(n)   282554  AY183455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta D2R6
    Dopamine 2-like receptor
    24(a)
    1 → many
    X(19898715-19922226)
    worm
    (Caenorhabditis elegans)
    Secernentea C09B7.1a3
    dop-21
    G-protein coupled receptor3
    dop-21
    31(a)
    (best of 2)3
    46.84(n)1
    39.2(a)1
      X(2709003-2717449)3
    1793471  NM_001269198.11  NP_001256127.11 


    ENSEMBL Gene Tree for DRD3 (if available)
    TreeFam Gene Tree for DRD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRD3 gene
    HTR2A2  DRD42  DRD22  CHRM12  CHRM22  HRH32  HTR2B2  HRH42  
    HTR2C2  HRH12  CHRM52  CHRM42  CHRM32  
    Selected SIMAP similar genes for DRD3 using alignment to 6 protein entries:     DRD3_HUMAN (see all proteins) (see all similar genes):
    NPY2R    HCRTR2    NPFFR1    ADRA1D    DRD2    GPR19
    GPR83    ADORA2B    dopamine D4 receptor    hA2aR    HTR2A    NMUR1
    dopamine D4 receptor/ DRD4    alpha 1c-adrenoceptor subtype    HRH3    HTR2C    5HT1A    HTR1A

    DRD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DRD3 (see all 1219)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491227731,2
    Cuntested1113858354(+) AGGATA/GAGCGC 4 L syn10--------
    rs62801,2,,4
    C,F,O,A,Hother1113858446(+) GTGGCT/CACTCA 4 /S /G mis1 ese333Minor allele frequency- C:0.49MN NS EA EU NA WA 7277
    rs98170631,2
    C,F,H--113815056(+) AGGAAT/CGGGCC 2 -- ds500124Minor allele frequency- C:0.42NA EA NS WA 2844
    rs1470732211,2
    --113815121(+) TGGCT-/GGGGGT
    GGGGGGGG
    GTTCT
    2 -- ds50010--------
    rs1420775821,2
    --113815148(+) GCTGAA/TTTCAA 2 -- ds50010--------
    rs1511395321,2
    --113815216(+) CATGCC/TTCTGA 2 -- ds50010--------
    rs37327901,2
    C,F,H--113815231(+) AATTTA/TGTGTG 2 -- ds500125Minor allele frequency- N:0.00EA NA NS WA 2972
    rs1132267121,2
    F--113815314(+) CAGAAC/TGAAGT 2 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1834304081,2
    --113815363(+) GGACAC/TATCTG 2 -- ds50010--------
    rs1879711791,2
    --113815436(+) GACACC/TGCACA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DRD3 (113847499 - 113918254 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DRD3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2841CNV Deletion18987735
    esv2725782CNV Deletion23290073
    esv1654104CNV Deletion17803354
    esv990133CNV Deletion20482838
    dgv25e197CNV Deletion19546169
    esv1006467CNV Deletion20482838
    esv2537070CNV Deletion19546169
    esv1358990CNV Insertion17803354
    nsv237833CNV Loss16902084
    esv9452CNV Loss19470904

    Human Gene Mutation Database (HGMD): DRD3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DRD3
    DNA2.0 Custom Variant and Variant Library Synthesis for DRD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 126451   
    OMIM disorders: 181500  190300  
    UniProtKB/Swiss-Prot: DRD3_HUMAN, P35462
  • Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by
    postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The
    condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional
    disability or even incapacitation. Inheritance is autosomal dominant. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry

  • Selected diseases for DRD3 (see all 57):    
    About MalaCards
    tremor    essential tremor    lingual-facial-buccal dyskinesia    pathological gambling
    cocaine dependence    obsessive-compulsive personality disorder    delusional disorder    substance dependence
    opiate dependence    drug addiction    schizophrenia    migraine without aura
    tardive dyskinesia    drug dependence    schizoaffective disorder    early-onset schizophrenia
    restless legs syndrome    myoclonus-dystonia    substance abuse    alcohol abuse

    6 diseases from the University of Copenhagen DISEASES database for DRD3:
    Schizophrenia     Essential tremor     Substance dependence     Parkinson's disease
    Pathological gambling     Substance abuse

    DRD3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for DRD3 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 76.4 159 19897343 (6), 9674978 (5), 11104840 (4), 18449897 (4) (see all 72)
    parkinson disease 56.6 13 8891576 (2), 19371585 (2), 17174156 (2), 19711120 (1) (see all 10)
    drug addiction 53.9 9 10432116 (1), 19128200 (1), 15960988 (1), 17627675 (1) (see all 8)
    essential tremor 51.8 10 18316228 (2), 19645064 (2), 16809426 (1), 19524641 (1)
    bipolar disorder 48.9 20 15539862 (2), 8509522 (2), 11093065 (2), 12834818 (2) (see all 13)
    cocaine dependence 44.7 12 12893467 (4), 10523822 (4), 19503018 (1), 9154209 (1)
    movement disorders 44.5 4 19058789 (1), 10893495 (1), 11179771 (1)
    drug dependence 43.3 7 15963538 (3), 9702742 (2), 17155853 (1)
    substance dependence 37 2 9790747 (1), 11681590 (1)
    psychotic 35 11 11104840 (2), 10490702 (2), 11723200 (2), 9779662 (1) (see all 7)

    Genetic Association Database (GAD): DRD3
    Human Genome Epidemiology (HuGE) Navigator: DRD3 (202 documents)

    Export disorders for DRD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRD3 gene, integrated from 10 sources (see all 603):
    (articles sorted by number of sources associating them with DRD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. (PubMed id 16809426)1, 2, 4, 9 Jeanneteau F.... Sokoloff P. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. (PubMed id 9034004)1, 2, 4, 9 Chen C.-H.... Hsiao K.-J. (Am. J. Med. Genet. 1997)
    3. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. (PubMed id 19897343)1, 4, 9 Nunokawa A....Someya T. (Schizophr. Res. 2010)
    4. Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia. (PubMed id 19217756)1, 4, 9 Zai C.C....Kennedy J.L. (Eur Neuropsychopharmacol 2009)
    5. Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor. (PubMed id 19645064)1, 4, 9 GarcA-a-MartA-n E....JimAcnez-JimAcnez F.J. (Mov. Disord. 2009)
    6. Dopamine D3 receptor gene polymorphism influences on behavioral and psychological symptoms of dementia (BPSD) in mild dementia of Alzheimer's type. (PubMed id 19363270)1, 4, 9 Sato N....Morita Y. (J. Alzheimers Dis. 2009)
    7. Structural evaluation of type 3 dopaminergic receptor gene (DRD3) in chronic anovulatory women. (PubMed id 18393218)1, 4, 9 Santos A.D....Longui C.A. (Genet. Mol. Res. 2008)
    8. Effects of the dopamine D3 receptor (DRD3) gene polymorphisms on risperidone response: a pharmacogenetic study. (PubMed id 17429404)1, 4, 9 Xuan J....He L. (Neuropsychopharmacology 2008)
    9. Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. (PubMed id 14681904)1, 4, 9 Szekeres G....Janka Z. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    10. DRD3 and DAT1 genes in schizophrenia: an association study. (PubMed id 11104840)1, 4, 9 Joober R....Rouleau G.A. (J Psychiatr Res 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1814 HGNC: 3024 AceView: DRD3 Ensembl:ENSG00000151577 euGenes: HUgn1814
    ECgene: DRD3 Kegg: 1814 H-InvDB: DRD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DRD3 Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=DRD3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRD3 gene:
    Search GeneIP for patents involving DRD3

    Licensable Technologies for DRD3 gene:
    Weizmann Institute:Diagnosis and Follow-up of Schizophrenia
    GeneCards and IP:
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