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Aliases for DRD3 Gene

Aliases for DRD3 Gene

  • Dopamine Receptor D3 2 3 5
  • Dopamine D3 Receptor 4
  • Essential Tremor 1 3
  • D3DR 3
  • ETM1 3
  • FET1 3

External Ids for DRD3 Gene

Previous GeneCards Identifiers for DRD3 Gene

  • GC03M110629
  • GC03M113418
  • GC03M115128
  • GC03M115168
  • GC03M115330
  • GC03M113847
  • GC03M111221

Summaries for DRD3 Gene

Entrez Gene Summary for DRD3 Gene

  • This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD3 Gene

DRD3 (Dopamine Receptor D3) is a Protein Coding gene. Diseases associated with DRD3 include essential tremor and schizophrenia. Among its related pathways are Signaling by GPCR and Beta-Adrenergic Signaling. GO annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for DRD3 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Tocris Summary for DRD3 Gene

  • D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion.

Gene Wiki entry for DRD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD3 Gene

Genomics for DRD3 Gene

Regulatory Elements for DRD3 Gene

Genomic Location for DRD3 Gene

Chromosome:
3
Start:
114,127,797 bp from pter
End:
114,199,407 bp from pter
Size:
71,611 bases
Orientation:
Minus strand

Genomic View for DRD3 Gene

Genes around DRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD3 Gene

Proteins for DRD3 Gene

  • Protein details for DRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35462-DRD3_HUMAN
    Recommended name:
    D(3) dopamine receptor
    Protein Accession:
    P35462
    Secondary Accessions:
    • A1A4V5
    • Q4VBM8

    Protein attributes for DRD3 Gene

    Size:
    400 amino acids
    Molecular mass:
    44225 Da
    Quaternary structure:
    • Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).
    SequenceCaution:
    • Sequence=AAA03543.1; Type=Frameshift; Positions=288; Evidence={ECO:0000305}; Sequence=AAA64369.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DRD3 Gene

    Alternative splice isoforms for DRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRD3 Gene

Proteomics data for DRD3 Gene at MOPED

Post-translational modifications for DRD3 Gene

  • Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
  • Glycosylation at Asn 12, Asn 19, Asn 97, and Asn 173
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD3 Gene

Antibody Products

No data available for DME Specific Peptides for DRD3 Gene

Domains & Families for DRD3 Gene

Gene Families for DRD3 Gene

Graphical View of Domain Structure for InterPro Entry

P35462

UniProtKB/Swiss-Prot:

DRD3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD3: view

Function for DRD3 Gene

Molecular function for DRD3 Gene

GENATLAS Biochemistry:
dopamine receptor D3,adenylate cyclase inhibiting,G protein coupled receptor superfamily (no evidence for association of sequence variants and bipolar disorder),or attention-deficit hyperactivity disorder,some evidence for association with schizophrenia,at least in Caucasians
UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10692483
GO:0035240 dopamine binding IEA,IBA --
genes like me logo Genes that share ontologies with DRD3: view
genes like me logo Genes that share phenotypes with DRD3: view

Animal Models for DRD3 Gene

MGI Knock Outs for DRD3:

Animal Model Products

miRNA for DRD3 Gene

miRTarBase miRNAs that target DRD3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRD3 Gene

Localization for DRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD3 Gene

Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD3 Gene COMPARTMENTS Subcellular localization image for DRD3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DRD3: view

Pathways & Interactions for DRD3 Gene

genes like me logo Genes that share pathways with DRD3: view

Gene Ontology (GO) - Biological Process for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001963 synaptic transmission, dopaminergic IEA,IBA --
GO:0001975 response to amphetamine IEA --
GO:0002016 regulation of blood volume by renin-angiotensin IEA --
GO:0002031 G-protein coupled receptor internalization IEA,IDA 18424554
genes like me logo Genes that share ontologies with DRD3: view

No data available for SIGNOR curated interactions for DRD3 Gene

Drugs & Compounds for DRD3 Gene

(122) Drugs for DRD3 Gene - From: Novoseek, DGIdb, DrugBank, HMDB, IUPHAR, ApexBio, Tocris, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramipexole Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Dopamine agonist 137
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Dopamine Approved Pharma Full agonist, Agonist, agonist, Target 3084
Haloperidol Approved Pharma Antagonist, antagonist, Target, inverse agonist Antipsychotic drug 136
Domperidone Approved, Investigational Pharma Antagonist, antagonist, Target Drug for gastroparesis 44

(21) Additional Compounds for DRD3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis flupentixol
Antagonist
trans flupenthixol
Antagonist
(+)-PD 128907 hydrochloride
300576-59-4
7-Hydroxy-DPAT hydrobromide
76135-30-3
7-Hydroxy-PIPAT maleate
200722-46-9

(5) Tocris Compounds for DRD3 Gene

Compound Action Cas Number
(+)-PD 128907 hydrochloride D3 agonist (D3 > D2 > D4) 300576-59-4
7-Hydroxy-DPAT hydrobromide Dopamine agonist (D3 > D2 < > D4) 76135-30-3
7-Hydroxy-PIPAT maleate D3 agonist (D3 > D2) 200722-46-9
Pramipexole dihydrochloride Selective D3 agonist 104632-25-9
Rotigotine hydrochloride Dopamine D2/D3 agonist 125572-93-2

(27) ApexBio Compounds for DRD3 Gene

Compound Action Cas Number
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Aripiprazole Antipsychotic 129722-12-9
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Haloperidol Antipsychotic drug 52-86-8
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Metoclopramide Dopamine receptor antagonist 364-62-5
Paliperidone 144598-75-4
PD128907 HCl 112960-16-4
Pergolide mesylate 66104-23-2
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Rotigotine Agonist of dopamine D2/D3 receptor 99755-59-6
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Sitaxentan sodium 210421-74-2
genes like me logo Genes that share compounds with DRD3: view

Drug Products

Transcripts for DRD3 Gene

Unigene Clusters for DRD3 Gene

Dopamine receptor D3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRD3 Gene

No ASD Table

Relevant External Links for DRD3 Gene

GeneLoc Exon Structure for
DRD3
ECgene alternative splicing isoforms for
DRD3

Expression for DRD3 Gene

mRNA expression in normal human tissues for DRD3 Gene

mRNA differential expression in normal tissues according to GTEx for DRD3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x25.6), Brain - Caudate (basal ganglia) (x9.2), and Brain - Putamen (basal ganglia) (x8.7).

SOURCE GeneReport for Unigene cluster for DRD3 Gene Hs.121478

mRNA Expression by UniProt/SwissProt for DRD3 Gene

P35462-DRD3_HUMAN
Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with DRD3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DRD3 Gene

Orthologs for DRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DRD3 35
  • 89.19 (n)
  • 89.65 (a)
DRD3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRD3 35
  • 89.67 (n)
  • 93.75 (a)
DRD3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd3 35
  • 87.13 (n)
  • 90.73 (a)
Drd3 16
Drd3 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DRD3 35
  • 99.17 (n)
  • 99.5 (a)
DRD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd3 35
  • 85.71 (n)
  • 89.97 (a)
oppossum
(Monodelphis domestica)
Mammalia DRD3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRD3 35
  • 70.94 (n)
  • 71.28 (a)
DRD3 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD3 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
drd3 35
  • 63.27 (n)
  • 68.1 (a)
drd3 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta D2R 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C09B7.1a 37
  • 31 (a)
C09B7.1b 37
  • 31 (a)
dop-2 35
  • 46.84 (n)
  • 39.2 (a)
dop-2 36
  • 16 (a)
ManyToMany
dop-3 36
  • 22 (a)
ManyToMany
Species with no ortholog for DRD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DRD3 Gene

ENSEMBL:
Gene Tree for DRD3 (if available)
TreeFam:
Gene Tree for DRD3 (if available)

Paralogs for DRD3 Gene

genes like me logo Genes that share paralogs with DRD3: view

Variants for DRD3 Gene

Sequence variations from dbSNP and Humsavar for DRD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6280 - 114,171,968(+) GTGGC(C/T)ACTCA reference, missense
rs226082 -- 114,162,166(+) TAAGG(C/T)ATTCA intron-variant
rs226083 -- 114,160,564(+) TGACT(A/G)CCCGA intron-variant
rs167770 -- 114,160,715(+) AGCTT(A/G)GAAAC intron-variant
rs167771 -- 114,157,428(+) ACAAT(A/G)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRD3 Gene

Variant ID Type Subtype PubMed ID
nsv877352 CNV Gain 21882294
nsv877353 CNV Gain 21882294
esv259489 OTHER Complex 20981092
esv1358990 CNV Insertion 17803354
esv2537070 CNV Deletion 19546169
esv990133 CNV Deletion 20482838
esv2841 CNV Deletion 18987735
esv2725782 CNV Deletion 23290073
esv1006467 CNV Deletion 20482838
nsv236315 CNV Loss 16902084
dgv25e197 CNV Deletion 19546169
esv9452 CNV Loss 19470904
esv1654104 CNV Deletion 17803354
nsv237833 CNV Loss 16902084

Variation tolerance for DRD3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRD3 Gene

HapMap Linkage Disequilibrium report
DRD3
Human Gene Mutation Database (HGMD)
DRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD3 Gene

Disorders for DRD3 Gene

MalaCards: The human disease database

(28) MalaCards diseases for DRD3 Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
essential tremor
  • benign essential tremor
schizophrenia
  • schizophrenia 12
tremor
bipolar disorder
  • major affective disorder 1
obsessive-compulsive personality disorder
  • anankastic personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search DRD3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DRD3_HUMAN
  • Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:16650084, ECO:0000269 PubMed:16809426}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for DRD3

Genetic Association Database (GAD)
DRD3
Human Genome Epidemiology (HuGE) Navigator
DRD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRD3
genes like me logo Genes that share disorders with DRD3: view

No data available for Genatlas for DRD3 Gene

Publications for DRD3 Gene

  1. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. (PMID: 16809426) Jeanneteau F. … Sokoloff P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23 48 67
  2. Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors. (PMID: 18831971) Tadori Y. … Kikuchi T. (Eur. J. Pharmacol. 2008) 3 23 25 26
  3. The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. (PMID: 17301410) Ostadali M.R. … Boulhari J. (Iran J Allergy Asthma Immunol 2004) 23 25 26
  4. Expression and pharmacological characterization of the human D3 dopamine receptor. (PMID: 8301582) Freedman S.B. … McAllister G. (J. Pharmacol. Exp. Ther. 1994) 3 25 26
  5. Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium. (PMID: 19309018) van Munster B.C. … Korevaar J.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23

Products for DRD3 Gene

Sources for DRD3 Gene

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