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DRD2 Gene

protein-coding   GIFtS: 73
GCID: GC11M113280

Dopamine Receptor D2

  See DRD2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dopamine Receptor D21 2     D(2) Dopamine Receptor2
Dopamine D2 Receptor2 3     Dopamine Receptor D2 Isoform2
D2DR2     Seven Transmembrane Helix Receptor2
D2R2     

External Ids:    HGNC: 30231   Entrez Gene: 18132   Ensembl: ENSG000001492957   OMIM: 1264505   UniProtKB: P144163   

Export aliases for DRD2 gene to outside databases

Previous GC identifers: GC11M115633 GC11M114792 GC11M113314 GC11M112817 GC11M112785 GC11M109208


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DRD2 Gene:
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl
cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been
associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding
different isoforms. A third variant has been described, but it has not been determined whether this form is
normal or due to aberrant splicing. (provided by RefSeq, Jul 2008)

GeneCards Summary for DRD2 Gene:
DRD2 (dopamine receptor D2) is a protein-coding gene. Diseases associated with DRD2 include myoclonus-dystonia, and hemiparkinsonism-hemiatrophy syndrome. GO annotations related to this gene include potassium channel regulator activity and identical protein binding. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By
similarity)

summary for DRD2 Gene:
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1,
D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle
where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The
human D2 receptor gene has been localized to chromosome 11 (11q22-23).

Gene Wiki entry for DRD2 (Dopamine receptor D2) Gene

PharmGKB "VIP" summary for DRD2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DRD2 gene promoter:
         CREB   GR   Sp1   p300   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRD2 promoter sequence
   Search Chromatin IP Primers for DRD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q22-q23

DRD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRD2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M113280:  view genomic region     (about GC identifiers)

Start:
113,280,317 bp from pter      End:
113,346,413 bp from pter
Size:
66,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416 (See protein sequence)
Recommended Name: D(2) dopamine receptor  
Size: 443 amino acids; 50619 Da
Subunit: Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced
downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2.
Interacts with ARRB2 (By similarity). Interacts with GNAI1. Interacts with GNAI2 isoform sGi2, the interaction
allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist
stimulation. Interacts with HTR2A
2 PDB 3D structures from and Proteopedia for DRD2:
1I15 (3D)        2YOU (3D)    
Secondary accessions: Q9NZR3 Q9UPA9
Alternative splicing: 3 isoforms:  P14416-1   P14416-2   P14416-3   

Explore the universe of human proteins at neXtProt for DRD2: NX_P14416

Explore proteomics data for DRD2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn17, Asn23
  • Modification sites at PhosphoSitePlus

  • See DRD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000786.1  NP_057658.2  

    ENSEMBL proteins: 
     ENSP00000278597   ENSP00000354859   ENSP00000441068   ENSP00000442172   ENSP00000438215  
     ENSP00000438419   ENSP00000441474   ENSP00000347474  
    Reactome Protein details: P14416

    DRD2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant DRD2 Protein
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    Novus Biologicals DRD2 Proteins
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for DRD2

     
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    DRD2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DRD2
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    DRD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript DRD2-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for DRD2
    Cloud-Clone Corp. CLIAs for DRD2
    Search eBioscience for ELISAs for DRD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DRD: GPCR / Class A : Dopamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: D2 receptor
    Dopamine receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002233 ADR_fam
     IPR001922 Dopamine_D2_rcpt
     IPR000929 Dopamine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P14416

    ProtoNet protein and cluster: P14416

    2 Blocks protein domains:
    IPB000929 Dopamine receptor signature
    IPB001922 Dopamine D2 receptor signature


    UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with DRD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRD2_HUMAN, P14416
    Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By
    similarity)

         Genatlas biochemistry entry for DRD2:
    dopamine receptor D2 (two isoforms),adenylate cyclase inhibiting,G protein coupled receptor superfamily,expressed
    in the basal ganglia (contradictory evidence for association of the S311C variant with schizophrenia),regulated
    by DNA methylation,involved in the regulation of appetite and growth hormone

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA2531656
    GO:0004930G-protein coupled receptor activity ----
    GO:0004935adrenergic receptor activity IEA--
    GO:0004952dopamine neurotransmitter receptor activity ----
    GO:0005102receptor binding ----
         
    Find genes that share ontologies with DRD2           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Drd2) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with DRD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DRD2: Drd2tm2Ebo Drd2tm1Low Drd2tm1.2Mrub Drd2tm1Yyw Drd2tm1Mok Drd2tm1Schm
                                                         Drd2tm1Ebo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DRD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRD2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DRD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DRD2 (see all 15):
    hsa-miR-615-5p hsa-miR-330-5p hsa-miR-509-5p hsa-miR-200a hsa-miR-1205 hsa-miR-141 hsa-miR-1184 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDRD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DRD2
    Predesigned siRNA for gene silencing in human, mouse, rat DRD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DRD2

    Clone
    Products:
         
    OriGene clones in human, mouse for DRD2 (see all 12)
    OriGene ORF clones in mouse, rat for DRD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DRD2 (NM_000795)
    Sino Biological Human cDNA Clone for DRD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD2
    Addgene plasmids for DRD2 

    Cell Line
    Products:
         
    GenScript DRD2-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for DRD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRD2_HUMAN, P14416: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA8413587
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with DRD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DRD2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Dopamine receptors0.00
    Amine ligand-binding receptors0.79
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    4Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with DRD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DRD2
        CDK5 Pathway
    Signaling in Gap Junctions
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for DRD2
        Development Dopamine D2 receptor transactivation of EGFR

    4 BioSystems Pathways for DRD2
        Hypothetical Network for Drug Addiction
    Nicotine Activity on Dopaminergic Neurons
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs


    2 Reactome Pathways for DRD2
        Dopamine receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for DRD2
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for DRD2) (see all 7):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Dopaminergic synapse
    Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DRD2 (see all 7): 
              Parkinson's Disease in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              Neurogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DRD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DRD2 (P144161, 2, 3 ENSP000003548594) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD2P144161, 2EBI-2928178,EBI-2928178 MINT-7300158 MINT-7300532 MINT-7300553 MINT-7300514
    PPP1R9BQ96SB32, 3MINT-4953534 I2D: score=6 
    SLC6A3Q019591, 2, 3, ENSP000002703494EBI-2928178,EBI-6661445 MINT-4789680 MINT-4789661 MINT-4789619 MINT-4789636 I2D: score=3 STRING: ENSP00000270349
    CALM1P621583, ENSP000003494674I2D: score=4 STRING: ENSP00000349467
    CALM2P621583I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 97):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis ISS--
    GO:0001666response to hypoxia IEA--
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0001964startle response ----
    GO:0001975response to amphetamine ISS--

    Find genes that share ontologies with DRD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DRD2
      Browse compounds at ApexBio 

    Compounds for DRD2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Rotigotine hydrochlorideDopamine D2/D3 agonist[125572-93-2]
    L-741,626 High affinity D2 antagonist[81226-60-0]
    Prochlorperazine dimaleateD2 receptor antagonist. Also 5-HT3 and nAChR antagonist[84-02-6]
    Sumanirole maleateD2-selective agonist[179386-43-7]
    B-HT 920D2 receptor agonist. Also alpha2 agonist and 5-HT3 antagonist[36085-73-1]

    5 HMDB Compounds for DRD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AripiprazoleAbilify (see all 3)129722-12-9--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    RisperidoneBelivon (see all 7)106266-06-2--

    Selected DrugBank Compounds for DRD2 (see all 68)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ApomorphineApomorfin (see all 9)41372-20-7targetagonist11215397 11212866 11692072 11343576 11752352 10494453 10641988 18691132
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist10721819 11444429 10626749 12010185 12753422 11752352 10641988 18691132
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist12464354 11436517 12008749 8951172 12721865 11752352 18303487 15341508
    Haloperidol-- 52-86-8targetantagonist15894081 16730699 20643630 11752352 16132064 7520908 17134027 17316700
    Olanzapine-- 132539-06-1targetantagonist agonist17092971 17067304 16730699 16513877 17848919 11752352 17316700 14575800
    PergolidePergolida [INN-Spanish] (see all 4)66104-22-1targetagonist10516878 11752352 1674528 3828803 2860228 10641988 18691132 16842172
    PimozidePimozida [INN-Spanish] (see all 2)2062-78-4targetantagonist7855217 12828573 8301582 11752352 10503726 8082693 11873706 2378927
    Flupenthixol-- 2709-56-0targetantagonist7498321 6149133 11752352 1674528 11873706 8797192 17111172
    Levodopa3,4-dihydroxyphenylalanine (see all 4)59-92-7targetagonist15728856 11978145 18549347 15824260 9633680 17553470 15710490
    Loxapine-- 1977-10-2targetantagonist15694653 9342550 9570468 8665533 6239298 11752352 8101879

    Selected IUPHAR Ligands for DRD2 (D2 receptor) (see all 36)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]nemonapride
    AntagonistAntagonist10.914535946
    lisuride
    AgonistPartial agonist9.2 - 9.512388666
    eticlopride
    AntagonistAntagonist9.27907989 8301592
    cabergoline
    AgonistPartial agonist9 - 9.212388666
    (-)-N-porphynorapomorphine
    AgonistFull agonist7.5 - 8.98301582 7756621
    terguride
    AntagonistAntagonist8.912388666
    pimozide
    AntagonistAntagonist7 - 8.88301582 1354163
    haloperidol
    AntagonistAntagonist7.4 - 8.88301582 7907989 1354163 7862709 7664822
    (+)-butaclamol
    AntagonistAntagonist7.5 - 8.77576010 8301582 7907989 8301592
    roxindole
    AntagonistAntagonist8.612388666

    Selected Novoseek inferred chemical compound relationships for DRD2 gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 93 842 8242725 (4), 18363853 (3), 8208404 (3), 16766383 (3) (see all 99)
    ibzm 90.6 29 9046079 (4), 9613734 (2), 16259998 (2), 7984527 (2) (see all 23)
    raclopride 84.4 25 1365855 (2), 7753373 (1), 7790956 (1), 1978494 (1) (see all 23)
    quinpirole 83.9 35 7957635 (1), 15857393 (1), 17179741 (1), 19298320 (1) (see all 32)
    haloperidol 82.6 87 1533719 (3), 7566476 (2), 1978483 (2), 11697576 (2) (see all 69)
    (11c)-n-methylspiperone 81.6 16 10647606 (3), 7909948 (2), 17413189 (1), 7480390 (1) (see all 10)
    remoxipride 80.4 23 1978494 (4), 1978483 (2), 11607043 (2), 8153056 (1) (see all 17)
    clozapine 80 64 16040180 (7), 7542051 (4), 16738543 (2), 9577836 (2) (see all 47)
    2'-iodospiperone 79.7 9 8534585 (3), 7790943 (3), 1399682 (1)
    bromocriptine 79.5 46 20138024 (2), 8012964 (2), 9134209 (2), 8951172 (1) (see all 37)

    Selected PharmGKB related drug/compound annotations for DRD2 gene (see all 10)    About this table
    Drug/compound PharmGKB Annotation
    antipsychoticsCA  
    aripiprazoleCA  
    bromperidolCA  
    chlorpromazineCA  
    clozapine  CA  
    disulfiramCA  
    methadoneCA  
    nemonaprideCA  
    olanzapineCA  
    risperidoneCA  



    Find genes that share compounds with DRD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for DRD2 gene (2 alternative transcripts): 
    NM_000795.3  NM_016574.3  

    Unigene Cluster for DRD2:

    Dopamine receptor D2
    Hs.73893  [show with all ESTs]
    Unigene Representative Sequence: NM_000795
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346454 ENST00000362072 ENST00000544518 ENST00000542968 ENST00000538967
    ENST00000540600(uc009yyr.1) ENST00000535984 ENST00000539420 ENST00000543292
    ENST00000542616 ENST00000355319(uc010rwv.2 uc001pnz.3 uc001poa.4 uc001pob.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DRD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DRD2 (see all 15):
    hsa-miR-615-5p hsa-miR-330-5p hsa-miR-509-5p hsa-miR-200a hsa-miR-1205 hsa-miR-141 hsa-miR-1184 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDRD2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DRD2 (NM_000795)
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    Addgene plasmids for DRD2 
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    Additional mRNA sequence: 

    AB209832.1 AB451480.1 AF176812.1 AK308777.1 BC021195.2 M29066.1 M30625.1 S62137.1 
    S69899.1 X51362.1 X51645.1 

    5 DOTS entries:

    DT.91757826  DT.99961527  DT.97836669  DT.91757824  DT.100775079 

    Selected AceView cDNA sequences (see all 34):

    BE795107 BC021195 NM_000795 BM931977 AI369867 BE266564 BM685017 AF176812 
    BX283073 AA316796 NM_016574 BQ719305 BF311583 BV203633 X51645 BQ879192 
    BF311952 BI195997 M29066 AI732883 BE798784 BG827135 BM711919 X51362 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DRD2 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                          -     -     -                                                                       -                                 
    SP2:                                                              -                                               -                                 
    SP3:                                                                                                                                                
    SP4:                          -     -     -                                                                 -     -                                 
    SP5:        -     -     -     -     -     -                                                                                                         


    ECgene alternative splicing isoforms for DRD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DRD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCAAACTA
    DRD2 Expression
    About this image


    DRD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    DRD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73893
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DRD2 (see all 7): 
              Parkinson's Disease in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              Neurogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DRD2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drd21 , 5 dopamine receptor D21, 5 90.82(n)1
    95.71(a)1
      9 (26.72 cM)5
    134891  NM_010077.21  NP_034207.21 
     493406625 
    chicken
    (Gallus gallus)
    Aves DRD21 dopamine receptor D2 78.67(n)
    81.19(a)
      428252  NM_001113290.1  NP_001106761.1 
    lizard
    (Anolis carolinensis)
    Reptilia DRD26
    dopamine receptor D2
    74(a)
    1 ↔ 1
    GL343354.1(422378-460712)
    African clawed frog
    (Xenopus laevis)
    Amphibia X59500.12   -- 75.34(n)    X59500.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY333792.12   -- 78.23(n)   378719  AY333792.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74313 G-protein coupled receptor protein
    signaling pathway amine receptor less
    39(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea dop-31 dop-3 48.47(n)
    44.44(a)
      188499  NM_001029737.2  NP_001024908.2 


    ENSEMBL Gene Tree for DRD2 (if available)
    TreeFam Gene Tree for DRD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRD2 gene
    HTR2A2  DRD42  CHRM12  CHRM22  HRH32  HTR2B2  HRH42  HTR2C2  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    Selected SIMAP similar genes for DRD2 using alignment to 4 protein entries:     DRD2_HUMAN (see all proteins) (see all similar genes):
    DRD3    CHRM1    HRH3    HTR4    ADRB3    hA2aR
    CHRM5    ADORA2A    alpha 1c-adrenoceptor subtype    TAAR2    ADRA1A    QRFPR
    DRD1    GPR19    HCRTR1    HCRTR2    5HT1A    HTR1A

    Find genes that share paralogs with DRD2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DRD2
    PGOHUM00000259095


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    DRD2_HUMAN, P14416: Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780].
    Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might
    also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of
    alcoholism and might contribute to suicide risk in alcoholics


    Selected SNPs for DRD2 (see all 1535)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048942201,2,,4
    Cpathogenic1113151014(-) TCACCG/ATCATG 4 /I /V mis11Minor allele frequency- A:0.00EU 1227
    rs1415074081,2
    C--109218617(+) ACAGG-/CA/CAC
    A
    /CACACA
    CACAC
    4 -- int1 cds10--------
    rs361525731,2
    C--109251801(+) CCATC-/TTTTTT 2 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs71167681,2
    C--109274250(+) CGCCCC/GGGGGC 2 -- ut51 ese37Minor allele frequency- G:0.37NA WA EA 366
    rs1135746611,2
    C--109275021(+) CTTTCCTTT/-  
            
    CTTTC
    2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1823645251,2
    --109276193(+) AGGAAA/GAAGAT 2 -- int10--------
    rs1444796651,2
    --109276267(+) CTTACA/GTGGCT 2 -- int10--------
    rs1478556131,2
    C--109276283(+) GATTTC/TATGCT 2 -- int10--------
    rs1863114581,2
    --109276296(+) CTGTGA/GGTGAG 2 -- int10--------
    rs1402489621,2
    --109276402(+) ATCTGC/TGGCCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for DRD2 (113280317 - 113346413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DRD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898394CNV Loss21882294
    nsv523683CNV Loss19592680

    Human Gene Mutation Database (HGMD): DRD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DRD2
    DNA2.0 Custom Variant and Variant Library Synthesis for DRD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 126450   
    OMIM disorders: 159900  
    UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
  • Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained
    involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary
    lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The
    age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
    Note=The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic
    dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258)

  • Selected diseases for DRD2 (see all 41):    
    About MalaCards
    myoclonus-dystonia    hemiparkinsonism-hemiatrophy syndrome    periodic limb movement disorder    schizophreniform disorder
    dystonia-11, myoclonic    striatonigral degeneration    bruxism    peripartum cardiomyopathy
    cocaine dependence    impulse control disorder    cocaine abuse    restless legs syndrome
    focal dystonia    mcleod syndrome    delusional disorder    tic disorder
    neuroleptic malignant syndrome    antisocial personality disorder    substance dependence    heroin dependence

    18 diseases from the University of Copenhagen DISEASES database for DRD2:
    Schizophrenia     Parkinson's disease     Alcohol dependence     Substance abuse
    Nicotine dependence     Pathological gambling     Cocaine dependence     Gilles de la Tourette syndrome
    Attention deficit hyperactivity disorder     Antisocial personality disorder     Hyperprolactinemia     Neuroleptic malignant syndrome
    Heroin dependence     Migraine     Schizoaffective disorder     Huntington's disease
    Delusional disorder     Pituitary adenoma

    Find genes that share disorders with DRD2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DRD2 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 83.9 339 2069495 (6), 8439241 (5), 17207969 (4), 18332877 (4) (see all 99)
    alcoholism 77.1 297 10235293 (6), 11236830 (5), 8871803 (5), 17850642 (5) (see all 99)
    parkinson disease 72.4 103 10647606 (4), 10990520 (4), 8489408 (3), 8543941 (3) (see all 65)
    prolactinoma 69.2 19 7907340 (2), 12552124 (2), 7641411 (1), 12972179 (1) (see all 14)
    parkinsonism 65 20 9452320 (1), 8534585 (1), 11993184 (1), 10416511 (1) (see all 20)
    hyperprolactinemia 64.4 16 16169407 (5), 19339912 (3), 19896213 (1), 12704865 (1) (see all 9)
    catalepsy 63.8 11 1975782 (1), 1358127 (1), 7901761 (1), 10958084 (1) (see all 9)
    extrapyramidal syndrome 61.2 7 9949416 (2), 11606886 (1), 8103229 (1), 16867246 (1)
    psychotic 60.6 19 10208638 (1), 11765615 (1), 15952869 (1), 7771917 (1) (see all 19)
    schizoaffective disorder 59.6 2 8439241 (1), 18786813 (1)

    GeneTests: DRD2
    GeneReviews: DRD2
    Genetic Association Database (GAD): DRD2
    Human Genome Epidemiology (HuGE) Navigator: DRD2 (863 documents)

    Export disorders for DRD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRD2 gene, integrated from 10 sources (see all 2163):
    (articles sorted by number of sources associating them with DRD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. (PubMed id 16867246)1, 4, 7, 9 Wu S.N....He L. (Acta Pharmacol. Sin. 2006)
    2. Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (PubMed id 15389757)1, 2, 4, 9 Johann M.... Wodarz N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005)
    3. Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (PubMed id 10220438)1, 2, 4, 9 Klein C.... Ozelius L.J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. (PubMed id 15694263)1, 4, 7, 9 Wu S....He L. (Neurosci. Lett. 2005)
    5. DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. (PubMed id 16513877)1, 4, 7, 9 Lencz T....Malhotra A.K. (Am J Psychiatry 2006)
    6. Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele. (PubMed id 15286066)1, 4, 7, 9 Young R.M....Noble E.P. (Br J Psychiatry 2004)
    7. Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function. (PubMed id 15140279)1, 4, 7, 9 Lane H.Y....Chang W.H. (Int. J. Neuropsychopharmacol. 2004)
    8. C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo. (PubMed id 19285111)1, 4, 9 Hirvonen M.M....Hietala J. (amp 2009)
    9. The interaction of DRD2 and violent victimization on depression: an analysis by gender and race. (PubMed id 18501970)1, 4, 9 Vaske J....Wright J.P. (J Affect Disord 2009)
    10. Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. (PubMed id 17007976)1, 4, 9 Wang T.J....Lu R.B. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1813 HGNC: 3023 AceView: DRD2 Ensembl:ENSG00000149295 euGenes: HUgn1813
    ECgene: DRD2 Kegg: 1813 H-InvDB: DRD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DRD2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/505383/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRD2 gene:
    Search GeneIP for patents involving DRD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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