Aliases for DRD2 Gene
External Ids for DRD2 Gene
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD2 Gene
DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include periodic limb movement disorder and hemiparkinsonism-hemiatrophy syndrome. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include identical protein binding and potassium channel regulator activity. An important paralog of this gene is CHRM4.
UniProtKB/Swiss-Prot for DRD2 Gene
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The human D2 receptor gene has been localized to chromosome 11 (11q22-23).