Aliases for DRD2 Gene
External Ids for DRD2 Gene
Previous GeneCards Identifiers for DRD2 Gene
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD2 Gene
DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include dystonia-11, myoclonic and cocaine dependence. Among its related pathways are Signaling by GPCR and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and identical protein binding. An important paralog of this gene is CHRM4.
UniProtKB/Swiss-Prot for DRD2 Gene
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are involved in the modulation of locomotion, reward, reinforcement and memory and learning.