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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DRD2 Gene

protein-coding   GIFtS: 74
GCID: GC11M113280

Dopamine Receptor D2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dopamine Receptor D21 2     D(2) Dopamine Receptor2
Dopamine D2 Receptor2 3     Dopamine Receptor D2 Isoform2
D2DR2     Seven Transmembrane Helix Receptor2
D2R2     

External Ids:    HGNC: 30231   Entrez Gene: 18132   Ensembl: ENSG000001492957   OMIM: 1264505   UniProtKB: P144163   

Export aliases for DRD2 gene to outside databases

Previous GC identifers: GC11M115633 GC11M114792 GC11M113314 GC11M112817 GC11M112785 GC11M109208


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DRD2 Gene:
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl
cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been
associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding
different isoforms. A third variant has been described, but it has not been determined whether this form is
normal or due to aberrant splicing. (provided by RefSeq, Jul 2008)

GeneCards Summary for DRD2 Gene: 
DRD2 (dopamine receptor D2) is a protein-coding gene. Diseases associated with DRD2 include hemiparkinsonism-hemiatrophy syndrome, and periodic limb movement disorder, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Amine ligand-binding receptors. GO annotations related to this gene include drug binding and ionotropic glutamate receptor binding. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By
similarity)

summary for DRD2 Gene:
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1,
D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle
where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The
human D2 receptor gene has been localized to chromosome 11 (11q22-23).

Gene Wiki entry for DRD2 (Dopamine receptor D2) Gene

PharmGKB "VIP" summary for DRD2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DRD2 gene promoter:
         CREB   GR   Sp1   p300   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DRD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q22-q23

DRD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRD2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M113280:  view genomic region     (about GC identifiers)

Start:
113,280,317 bp from pter      End:
113,346,413 bp from pter
Size:
66,097 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416 (See protein sequence)
Recommended Name: D(2) dopamine receptor  
Size: 443 amino acids; 50619 Da
Subunit: Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced
downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2.
Interacts with ARRB2 (By similarity). Interacts with GNAI1. Interacts with GNAI2 isoform sGi2, the interaction
allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist
stimulation
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for DRD2:
1I15 (3D)    
Secondary accessions: Q9NZR3 Q9UPA9
Alternative splicing: 3 isoforms:  P14416-1   P14416-2   P14416-3   

Explore the universe of human proteins at neXtProt for DRD2: NX_P14416

Explore proteomics data for DRD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14416

  • DRD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DRD2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000786.1  NP_057658.2  

    ENSEMBL proteins: 
     ENSP00000278597   ENSP00000354859   ENSP00000441068   ENSP00000442172   ENSP00000438215  
     ENSP00000438419   ENSP00000441474   ENSP00000347474  
    Reactome Protein details: P14416
    Human Recombinant Protein Products for DRD2: 
    EMD Millipore Purified and/or Recombinant DRD2 Protein
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    OriGene Protein Over-expression Lysate for DRD2
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    OriGene Custom Protein Services for DRD2
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    Novus Biologicals DRD2 Proteins
    Novus Biologicals DRD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DRD2 

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA8413587
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane ----

    DRD2 for ontologies           About GeneDecksing



    DRD2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DRD: GPCR / Class A : Dopamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: D2 receptor 
    Dopamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001922 Dopamine_D2_rcpt
     IPR000929 Dopamine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P14416

    ProtoNet protein and cluster: P14416

    2 Blocks protein domains:
    IPB000929 Dopamine receptor signature
    IPB001922 Dopamine D2 receptor signature


    UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
    Similarity: Belongs to the G-protein coupled receptor 1 family


    DRD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRD2_HUMAN, P14416
    Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By
    similarity)

         Genatlas biochemistry entry for DRD2:
    dopamine receptor D2 (two isoforms),adenylate cyclase inhibiting,G protein coupled receptor superfamily,expressed
    in the basal ganglia (contradictory evidence for association of the S311C variant with schizophrenia),regulated
    by DNA methylation,involved in the regulation of appetite and growth hormone

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA2531656
    GO:0004930G-protein coupled receptor activity ----
    GO:0004935adrenergic receptor activity IEA--
    GO:0004952dopamine neurotransmitter receptor activity ----
    GO:0005102receptor binding ----
         
    DRD2 for ontologies           About GeneDecksing


    Phenotypes:
         15/25 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Drd2) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    DRD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DRD2: Drd2tm2Ebo Drd2tm1Low Drd2tm1.2Mrub Drd2tm1Yyw Drd2tm1Mok Drd2tm1Schm
                                                         Drd2tm1Ebo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DRD2 
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    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate DRD2 (see all 15):
    hsa-miR-615-5p hsa-miR-330-5p hsa-miR-509-5p hsa-miR-200a hsa-miR-1205 hsa-miR-141 hsa-miR-1184 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDRD2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Premade adenovirus for overexpression of DRD2 in human, mouse 
                         Customized adenovirus for overexpression of DRD2

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DRD2 (NM_000795)
    Sino Biological Human cDNA Clone for DRD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DRD2 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Amine ligand-binding receptors0.79
    3Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    4Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DRD2
        Development Dopamine D2 receptor transactivation of EGFR

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DRD2
        CDK5 Pathway
    Signaling in Gap Junctions
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for DRD2
        Development Dopamine D2 receptor transactivation of EGFR

    4 BioSystems Pathways for DRD2
        Hypothetical Network for Drug Addiction
    Nicotine Activity on Dopaminergic Neurons
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs


    5/8        Reactome Pathways for DRD2 (see all 8)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)
    Dopamine receptors

    1 PharmGKB Pathway for DRD2
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    5         Kegg Pathways  (Kegg details for DRD2):
        Neuroactive ligand-receptor interaction
    Gap junction
    Dopaminergic synapse
    Cocaine addiction
    Alcoholism


    DRD2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DRD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/172 Interacting proteins for DRD2 (P144161, 2, 3 ENSP000003548594) via UniProtKB, MINT, STRING, and/or I2D (see all 172)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC6A3Q019592, 3, ENSP000002703494MINT-4789680 MINT-4789661 MINT-4789619 MINT-4789636 I2D: score=3 STRING: ENSP00000270349
    ADORA2AP292741, 3, ENSP000003366304EBI-2928178,EBI-2902702 I2D: score=5 STRING: ENSP00000336630
    PPP1R9BQ96SB32, 3MINT-4953534 I2D: score=6 
    CALM1P621583, ENSP000003494674I2D: score=4 STRING: ENSP00000349467
    DRD2P144162MINT-7300158 MINT-7300532 MINT-7300553 MINT-7300514
    About this table

    Gene Ontology (GO): 5/92 biological process terms (GO ID links to tree view) (see all 92):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis ISS--
    GO:0001666response to hypoxia IEA--
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0001964startle response ----
    GO:0001975response to amphetamine ISS--

    DRD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DRD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for DRD2

    Compounds for DRD2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Rotigotine hydrochlorideDopamine D2/D3 agonist[125572-93-2]
    L-741,626 High affinity D2 antagonist[81226-60-0]
    Prochlorperazine dimaleateD2 receptor antagonist. Also 5-HT3 and nAChR antagonist[84-02-6]
    Sumanirole maleateD2-selective agonist[179386-43-7]
    B-HT 920D2 receptor agonist. Also alpha2 agonist and 5-HT3 antagonist[36085-73-1]

    5 HMDB Compounds for DRD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AripiprazoleAbilify (see all 3)129722-12-9--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    RisperidoneBelivon (see all 7)106266-06-2--

    10/68 DrugBank Compounds for DRD2 (see all 68)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ApomorphineApomorfin (see all 9)41372-20-7targetagonist11215397 11212866 11692072 11343576 11752352 10494453 10641988 18691132
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist10721819 11444429 10626749 12010185 12753422 11752352 10641988 18691132
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist12464354 11436517 12008749 8951172 12721865 11752352 18303487 15341508
    Haloperidol-- 52-86-8targetantagonist15894081 16730699 20643630 11752352 16132064 7520908 17134027 17316700
    Olanzapine-- 132539-06-1targetantagonist agonist17092971 17067304 16730699 16513877 17848919 11752352 17316700 14575800
    PergolidePergolida [INN-Spanish] (see all 4)66104-22-1targetagonist10516878 11752352 1674528 3828803 2860228 10641988 18691132 16842172
    PimozidePimozida [INN-Spanish] (see all 2)2062-78-4targetantagonist7855217 12828573 8301582 11752352 10503726 8082693 11873706 2378927
    Flupenthixol-- 2709-56-0targetantagonist7498321 6149133 11752352 1674528 11873706 8797192 17111172
    Levodopa3,4-dihydroxyphenylalanine (see all 4)59-92-7targetagonist15728856 11978145 18549347 15824260 9633680 17553470 15710490
    Loxapine-- 1977-10-2targetantagonist15694653 9342550 9570468 8665533 6239298 11752352 8101879

    10/36 IUPHAR Ligands for DRD2 (D2 receptor) (see all 36)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]nemonapride
    AntagonistAntagonist10.914535946
    lisuride
    AgonistPartial agonist9.2 - 9.512388666
    eticlopride
    AntagonistAntagonist9.27907989 8301592
    cabergoline
    AgonistPartial agonist9 - 9.212388666
    (-)-N-porphynorapomorphine
    AgonistFull agonist7.5 - 8.98301582 7756621
    terguride
    AntagonistAntagonist8.912388666
    pimozide
    AntagonistAntagonist7 - 8.88301582 1354163
    haloperidol
    AntagonistAntagonist7.4 - 8.88301582 7907989 1354163 7862709 7664822
    (+)-butaclamol
    AntagonistAntagonist7.5 - 8.77576010 8301582 7907989 8301592
    roxindole
    AntagonistAntagonist8.612388666

    10/107 Novoseek inferred chemical compound relationships for DRD2 gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 93 842 8242725 (4), 18363853 (3), 8208404 (3), 16766383 (3) (see all 99)
    ibzm 90.6 29 9046079 (4), 9613734 (2), 16259998 (2), 7984527 (2) (see all 23)
    raclopride 84.4 25 1365855 (2), 7753373 (1), 7790956 (1), 1978494 (1) (see all 23)
    quinpirole 83.9 35 7957635 (1), 15857393 (1), 17179741 (1), 19298320 (1) (see all 32)
    haloperidol 82.6 87 1533719 (3), 7566476 (2), 1978483 (2), 11697576 (2) (see all 69)
    (11c)-n-methylspiperone 81.6 16 10647606 (3), 7909948 (2), 17413189 (1), 7480390 (1) (see all 10)
    remoxipride 80.4 23 1978494 (4), 1978483 (2), 11607043 (2), 8153056 (1) (see all 17)
    clozapine 80 64 16040180 (7), 7542051 (4), 16738543 (2), 9577836 (2) (see all 47)
    2'-iodospiperone 79.7 9 8534585 (3), 7790943 (3), 1399682 (1)
    bromocriptine 79.5 46 20138024 (2), 8012964 (2), 9134209 (2), 8951172 (1) (see all 37)

    9 PharmGKB related drug/compound annotations for DRD2 gene    About this table
    Drug/compound PharmGKB Annotation
    antipsychoticsCA  
    aripiprazoleCA  
    bromperidolCA  
    chlorpromazineCA  
    clozapineCA  
    methadoneCA  
    nemonaprideCA  
    olanzapineCA  
    risperidoneCA  

    Search CenterWatch for drugs/clinical trials and news about DRD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DRD2 gene (2 alternative transcripts): 
    NM_000795.3  NM_016574.3  

    Unigene Cluster for DRD2:

    Dopamine receptor D2
    Hs.73893  [show with all ESTs]
    Unigene Representative Sequence: NM_000795
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346454 ENST00000362072 ENST00000544518 ENST00000542968 ENST00000538967
    ENST00000540600(uc009yyr.1) ENST00000535984 ENST00000539420 ENST00000543292
    ENST00000542616 ENST00000355319(uc010rwv.2 uc001pnz.3 uc001poa.4 uc001pob.4)


    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate DRD2 (see all 15):
    hsa-miR-615-5p hsa-miR-330-5p hsa-miR-509-5p hsa-miR-200a hsa-miR-1205 hsa-miR-141 hsa-miR-1184 hsa-miR-9
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    Additional mRNA sequence: 

    AB209832.1 AB451480.1 AF176812.1 AK308777.1 BC021195.2 M29066.1 M30625.1 S62137.1 
    S69899.1 X51362.1 X51645.1 

    5 DOTS entries:

    DT.91757826  DT.99961527  DT.97836669  DT.91757824  DT.100775079 

    24/34 AceView cDNA sequences (see all 34):

    BE795107 BC021195 NM_016574 BG827135 BM685017 BX283073 BV203633 AI732883 
    AF176812 NM_000795 BF311583 BI195997 BQ879192 BM931977 AI369867 BQ719305 
    AA316796 X51645 BF311952 BE798784 BE266564 M29066 S69899 BF315049 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DRD2 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                          -     -     -                                                                       -                                 
    SP2:                                                              -                                               -                                 
    SP3:                                                                                                                                                
    SP4:                          -     -     -                                                                 -     -                                 
    SP5:        -     -     -     -     -     -                                                                                                         


    ECgene alternative splicing isoforms for DRD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DRD2 expression in normal human tissues (normalized intensities)      DRD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCAAACTA
    DRD2 Expression
    About this image


    DRD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Nose (Sensory Organs)
             sensory organ/nose   

    See DRD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DRD2

    SOURCE GeneReport for Unigene cluster: Hs.73893
        SABiosciences Expression via Pathway-Focused PCR Arrays including DRD2 (see all 7): 
              Parkinson's Disease in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              Neurogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DRD2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drd21 , 5 dopamine receptor D21, 5 90.82(n)1
    95.71(a)1
      9 (26.72 cM)5
    134891  NM_010077.21  NP_034207.21 
     493406625 
    chicken
    (Gallus gallus)
    Aves DRD21 dopamine receptor D2 78.59(n)
    81.42(a)
      428252  NM_001113290.1  NP_001106761.1 
    lizard
    (Anolis carolinensis)
    Reptilia DRD26
    Uncharacterized protein
    74(a)
    1 ↔ 1
    GL343354.1(422378-460712)
    African clawed frog
    (Xenopus laevis)
    Amphibia X59500.12   -- 75.34(n)    X59500.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY333792.12   -- 78.23(n)   378719  AY333792.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74313 G-protein coupled receptor protein
    signaling pathway more
    39(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea dop-31 Protein DOP-3 49.27(n)
    45.76(a)
      188499  NM_001029737.2  NP_001024908.2 


    ENSEMBL Gene Tree for DRD2 (if available)
    TreeFam Gene Tree for DRD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DRD2 gene
    HTR2A2  DRD42  HTR1A2  HTR1F2  HTR72  HTR2B2  ADRA2C2  HTR2C2  
    ADRA2A2  HTR1D2  ADRA2B2  DRD32  HTR1E2  HTR5A2  HTR1B2  
    18/27 SIMAP similar genes for DRD2 using alignment to 4 protein entries:     DRD2_HUMAN (see all proteins) (see all similar genes):
    DRD3    CHRM1    HRH3    HTR4    ADRB3    hA2aR
    CHRM5    ADORA2A    alpha 1c-adrenoceptor subtype    TAAR2    ADRA1A    QRFPR
    DRD1    GPR19    HCRTR1    5HT1A    HTR1A    GPR63

    DRD2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DRD2
    PGOHUM00000259095


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
    Polymorphism: Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780].
    Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might
    also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of
    alcoholism and might contribute to suicide risk in alcoholics


    10/1535 SNPs in DRD2 are shown (see all 1535)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048942201,2,4
    Cpathogenic1113151014(-) TCACCG/ATCATG 4 /I /V mis11Minor allele frequency- A:0.00EU 1227
    rs1415074081,2
    C--109218617(+) ACAGG-/CA/CAC
    A
    /CACACA
    CACAC
    4 -- int1 cds10--------
    rs361525731,2
    C--109251801(+) CCATC-/TTTTTT 2 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs71167681,2
    C--109274250(+) CGCCCC/GGGGGC 2 -- ut51 ese37Minor allele frequency- G:0.37NA WA EA 366
    rs1135746611,2
    C--109275021(+) CTTTCCTTT/-  
            
    CTTTC
    2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1823645251,2
    --109276193(+) AGGAAA/GAAGAT 2 -- int10--------
    rs1444796651,2
    --109276267(+) CTTACA/GTGGCT 2 -- int10--------
    rs1478556131,2
    C--109276283(+) GATTTC/TATGCT 2 -- int10--------
    rs1863114581,2
    --109276296(+) CTGTGA/GGTGAG 2 -- int10--------
    rs1402489621,2
    --109276402(+) ATCTGC/TGGCCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for DRD2 (113280317 - 113346413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DRD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898394CNV Loss21882294
    nsv523683CNV Loss19592680


    Human Gene Mutation Database (HGMD): DRD2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 126450   
    OMIM disorders: 159900  
    UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
  • Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained
    involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary
    lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The
    age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
    Note=The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic
    dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258)

  • 20/136 diseases for DRD2 (see all 136):    About MalaCards
    hemiparkinsonism-hemiatrophy syndrome    periodic limb movement disorder    schizophreniform disorder    cocaine abuse
    myoclonus-dystonia    opiate dependence    bruxism    striatonigral degeneration
    peripartum cardiomyopathy    cocaine dependence    restless legs syndrome    leptin receptor deficiency
    impulse control disorder    tic disorder    focal dystonia    prolactinoma
    myoclonus    neuroleptic malignant syndrome    mcleod syndrome    novelty seeking personality

    18 diseases from the University of Copenhagen DISEASES database for DRD2:
    Schizophrenia     Parkinson's disease     Alcohol dependence     Substance abuse
    Nicotine dependence     Pathological gambling     Cocaine dependence     Gilles de la Tourette syndrome
    Attention deficit hyperactivity disorder     Antisocial personality disorder     Hyperprolactinemia     Neuroleptic malignant syndrome
    Heroin dependence     Migraine     Schizoaffective disorder     Huntington's disease
    Delusional disorder     Pituitary adenoma

    DRD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for DRD2 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 83.9 339 2069495 (6), 8439241 (5), 17207969 (4), 18332877 (4) (see all 99)
    alcoholism 77.1 297 10235293 (6), 11236830 (5), 8871803 (5), 17850642 (5) (see all 99)
    parkinson disease 72.4 103 10647606 (4), 10990520 (4), 8489408 (3), 8543941 (3) (see all 65)
    prolactinoma 69.2 19 7907340 (2), 12552124 (2), 7641411 (1), 12972179 (1) (see all 14)
    parkinsonism 65 20 9452320 (1), 8534585 (1), 11993184 (1), 10416511 (1) (see all 20)
    hyperprolactinemia 64.4 16 16169407 (5), 19339912 (3), 19896213 (1), 12704865 (1) (see all 9)
    catalepsy 63.8 11 1975782 (1), 1358127 (1), 7901761 (1), 10958084 (1) (see all 9)
    extrapyramidal syndrome 61.2 7 9949416 (2), 11606886 (1), 8103229 (1), 16867246 (1)
    psychotic 60.6 19 10208638 (1), 11765615 (1), 15952869 (1), 7771917 (1) (see all 19)
    schizoaffective disorder 59.6 2 8439241 (1), 18786813 (1)

    GeneTests: DRD2
    GeneReviews: DRD2
    Genetic Association Database (GAD): DRD2
    Human Genome Epidemiology (HuGE) Navigator: DRD2 (863 documents)

    Export disorders for DRD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DRD2 gene, integrated from 9 sources (see all 2124):
    (articles sorted by number of sources associating them with DRD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. (PubMed id 16867246)1, 4, 7, 9 Wu S.N....He L. (2006)
    2. Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (PubMed id 15389757)1, 2, 4, 9 Johann M.... Wodarz N. (2005)
    3. Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (PubMed id 10220438)1, 2, 4, 9 Klein C.... Ozelius L.J. (1999)
    4. Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. (PubMed id 15694263)1, 4, 7, 9 Wu S....He L. (2005)
    5. DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. (PubMed id 16513877)1, 4, 7, 9 Lencz T....Malhotra A.K. (2006)
    6. Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele. (PubMed id 15286066)1, 4, 7, 9 Young R.M....Noble E.P. (2004)
    7. Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function. (PubMed id 15140279)1, 4, 7, 9 Lane H.Y....Chang W.H. (2004)
    8. C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo. (PubMed id 19285111)1, 4, 9 Hirvonen M.M....Hietala J. (2009)
    9. The interaction of DRD2 and violent victimization on depression: An analysis by gender and race. (PubMed id 18501970)1, 4, 9 Vaske J....Wright J.P. (2008)
    10. Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. (PubMed id 17007976)1, 4, 9 Wang T.J....Lu R.B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1813 HGNC: 3023 AceView: DRD2 Ensembl:ENSG00000149295 euGenes: HUgn1813
    ECgene: DRD2 Kegg: 1813 H-InvDB: DRD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DRD2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DRD2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DRD2 gene:
    Search GeneIP for patents involving DRD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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