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Aliases for DRD2 Gene

Aliases for DRD2 Gene

  • Dopamine Receptor D2 2 3 5
  • Dopamine D2 Receptor 3 4
  • Seven Transmembrane Helix Receptor 3
  • Dopamine Receptor D2 Isoform 3
  • D(2) Dopamine Receptor 3
  • D2DR 3
  • D2R 3

External Ids for DRD2 Gene

Previous GeneCards Identifiers for DRD2 Gene

  • GC11M115633
  • GC11M114792
  • GC11M112817
  • GC11M112785
  • GC11M109208
  • GC11M113280

Summaries for DRD2 Gene

Entrez Gene Summary for DRD2 Gene

  • This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD2 Gene

DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include Dystonia-11, Myoclonic and Cocaine Dependence. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and identical protein binding. An important paralog of this gene is DRD3.

UniProtKB/Swiss-Prot for DRD2 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Tocris Summary for DRD2 Gene

  • D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are involved in the modulation of locomotion, reward, reinforcement and memory and learning.

Gene Wiki entry for DRD2 Gene

PharmGKB "VIP" Summary for DRD2 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for DRD2 Gene

Genomics for DRD2 Gene

Regulatory Elements for DRD2 Gene

Enhancers for DRD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F113680 0.6 FANTOM5 ENCODE 16.3 -206.0 -205959 1.5 PKNOX1 CBX3 FEZF1 ZBTB40 ZNF488 TSHZ1 HDAC8 ZNF843 MEF2D TFDP1 DRD2 LRRC37A13P LOC105369499 TTC12 TMPRSS5 MTRF1LP1 LOC105369501
GH11F113312 0.2 ENCODE 10.9 +161.3 161269 3.6 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2 ZNF143 TTC12 DRD2 ENSG00000256757 ANKK1 LOC105369499 GC11M113268
GH11F113445 0.7 ENCODE 10.6 +28.4 28367 3.3 ATF1 JUN INSM2 ZNF175 FEZF1 ZNF316 SCRT2 PRDM10 ZNF600 FOS DRD2 MIR4301 GC11M113416 GC11M113417
GH11F113345 0.2 ENCODE 10.4 +129.5 129506 0.9 CTCF ENSG00000256757 DRD2 TTC12 GC11P113361
GH11F113387 0.2 ENCODE 10.4 +87.5 87535 0.7 CTCF POLR2A CTBP2 KDM6A DRD2 ANKK1 ENSG00000256757
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DRD2 on UCSC Golden Path with GeneCards custom track

Promoters for DRD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001772338 491 801 KLF1 KLF17 ZIC2 ZFHX2 GLIS2 POLR2A ZNF366 ZNF600 KLF8 EGR2

Genomic Location for DRD2 Gene

Chromosome:
11
Start:
113,409,595 bp from pter
End:
113,475,691 bp from pter
Size:
66,097 bases
Orientation:
Minus strand

Genomic View for DRD2 Gene

Genes around DRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD2 Gene

Proteins for DRD2 Gene

  • Protein details for DRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14416-DRD2_HUMAN
    Recommended name:
    D(2) dopamine receptor
    Protein Accession:
    P14416
    Secondary Accessions:
    • Q9NZR3
    • Q9UPA9

    Protein attributes for DRD2 Gene

    Size:
    443 amino acids
    Molecular mass:
    50619 Da
    Quaternary structure:
    • Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.

    Three dimensional structures from OCA and Proteopedia for DRD2 Gene

    Alternative splice isoforms for DRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRD2 Gene

Post-translational modifications for DRD2 Gene

  • Glycosylation at Asn 5, Asn 17, and Asn 23
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for DRD2 (Dopamine D2 R/DRD2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for DRD2

No data available for DME Specific Peptides for DRD2 Gene

Domains & Families for DRD2 Gene

Gene Families for DRD2 Gene

Suggested Antigen Peptide Sequences for DRD2 Gene

Graphical View of Domain Structure for InterPro Entry

P14416

UniProtKB/Swiss-Prot:

DRD2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD2: view

Function for DRD2 Gene

Molecular function for DRD2 Gene

GENATLAS Biochemistry:
dopamine receptor D2 (two isoforms),adenylate cyclase inhibiting,G protein coupled receptor superfamily,expressed in the basal ganglia (contradictory evidence for association of the S311C variant with schizophrenia),regulated by DNA methylation,involved in the regulation of appetite and growth hormone
UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA 8301582
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 NOT adrenergic receptor activity IBA --
GO:0004952 dopamine neurotransmitter receptor activity IEA --
genes like me logo Genes that share ontologies with DRD2: view
genes like me logo Genes that share phenotypes with DRD2: view

Human Phenotype Ontology for DRD2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DRD2 Gene

MGI Knock Outs for DRD2:

Animal Model Products

  • Taconic Biosciences Mouse Models for DRD2

miRNA for DRD2 Gene

miRTarBase miRNAs that target DRD2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DRD2
  • R&D Systems cDNA Clones for DRD2 (Dopamine D2 R/DRD2)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DRD2 Gene

Localization for DRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD2 Gene COMPARTMENTS Subcellular localization image for DRD2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IEA,IDA 8413587
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DRD2: view

Pathways & Interactions for DRD2 Gene

genes like me logo Genes that share pathways with DRD2: view

Gene Ontology (GO) - Biological Process for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis ISS --
GO:0001666 response to hypoxia IEA --
GO:0001963 synaptic transmission, dopaminergic IBA --
GO:0001964 startle response IEA --
GO:0001975 response to amphetamine ISS --
genes like me logo Genes that share ontologies with DRD2: view

No data available for SIGNOR curated interactions for DRD2 Gene

Drugs & Compounds for DRD2 Gene

(286) Drugs for DRD2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amisulpride Approved, Investigational Pharma Antagonist, antagonist, Target Dopamine D2/D3 receptor antagonist 0
Aripiprazole Approved, Investigational Pharma Antagonist, agonist, Target, antagonist, partial agonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 353
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication 114
Chlorpromazine Approved, Vet_approved Pharma Antagonist, antagonist, Target 17
Domperidone Approved, Investigational, Vet_approved Pharma Antagonist, antagonist, Target Drug for gastroparesis 48

(27) Additional Compounds for DRD2 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis flupentixol
Antagonist
trans flupenthixol
Antagonist
Promazine 5-sulfoxide
Prochlorperazine dimaleate
84-02-6

(5) Tocris Compounds for DRD2 Gene

Compound Action Cas Number
Aripiprazole High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 129722-12-9
L-741,626 High affinity D2 antagonist 81226-60-0
Prochlorperazine dimaleate D2 receptor antagonist. Also 5-HT3 and nAChR antagonist 84-02-6
Rotigotine hydrochloride Dopamine D2/D3 agonist 125572-93-2
Sumanirole maleate D2-selective agonist 179386-44-8

(121) ApexBio Compounds for DRD2 Gene

Compound Action Cas Number
(-)-Quinpirole hydrochloride 85798-08-9
(+)-AJ 76 hydrochloride Dopamine receptor antagonist 85378-82-1
(+)-UH 232 maleate 1217473-50-1
(R)-(-)-Apomorphine hydrochloride 314-19-2
(RS)-(±)-Sulpiride 15676-16-1
2-CMDO 24140-98-5
3-CPMT 14008-79-8
3'-Fluorobenzylspiperone maleate 1135278-61-3
3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride 202646-03-5
4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride 6109-35-9
6-Hydroxydopamine hydrobromide 636-00-0
7-Hydroxy-DPAT hydrobromide 76135-30-3
7-Hydroxy-PIPAT maleate 200722-46-9
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
AMI-193 5-HT/D2DR receptor antagonist 510-74-7
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Amisulpride hydrochloride Dopamine D2/D3 receptor antagonist 81342-13-4
Amoxapine GLYT2a transport activity inhibitor 14028-44-5
Aripiprazole Antipsychotic 129722-12-9
B-HT 920 D2 receptor agonist 36085-73-1
Brexpiprazole 5-HT2A, α1B-, and α2C-adrenergic receptors antagonist 913611-97-9
Bromocriptine mesylate 22260-51-1
BTCP maleate 207455-25-2
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Cariprazine D2/D3 partial agonist,antipsychotic drug 839712-12-8
Cariprazine hydrochloride Antipsychotic drug 1083076-69-0
Carmoxirole hydrochloride 115092-85-8
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Cocaine hydrochloride 53-21-4
CY 208-243 100999-26-6
D-Amphetamine sulfate 51-63-8
Dexpramipexole Neuroprotective agent 104632-28-2
Dexpramipexole dihydrochloride Neuroprotective agent 104632-27-1
Diclofensine hydrochloride 34041-84-4
Dihydrexidine hydrochloride 158704-02-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Droperidol 548-73-2
Eticlopride hydrochloride 97612-24-3
Flupenthixol dihydrochloride Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors 2413-38-9
GBR 12783 dihydrochloride 67469-75-4
GBR 12935 Dopamine inhibitor 76778-22-8
GBR 12935 dihydrochloride 67469-81-2
GBR 13069 dihydrochloride 67469-45-8
GR 103691 162408-66-4
GSK 789472 hydrochloride 1257326-24-1
Haloperidol Antipsychotic drug 52-86-8
Iloperidone Dopamine (D2) and serotonin (5HT2) receptor antagonist 133454-47-4
JHW 007 hydrochloride 202645-74-7
L-741,626 81226-60-0
L-741,742 hydrochloride 874882-93-6
L-745,870 trihydrochloride 866021-03-6
LE 300 274694-98-3
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
Loxapine Succinate 27833-64-3
L-Stepholidine D2/D1 receptor agonist 16562-13-3
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Mephedrone hydrochloride 1189726-22-4
Mesoridazine 0 5588-33-0
Mesoridazine Besylate 0 32672-69-8
Metoclopramide Dopamine receptor antagonist 364-62-5
Nemonapride 75272-39-8
NGB 2904 189061-11-8
NGD 94-1 178928-68-2
Nomifensine 32795-47-4
NPEC-caged-dopamine 1257326-23-0
OSU 6162 hydrochloride 156907-84-5
Paliperidone 144598-75-4
PAOPA 114200-31-6
PD 168077 maleate 630117-19-0
PD 168568 dihydrochloride 210688-56-5
PD128907 HCl 112960-16-4
Pemoline 2152-34-3
Penfluridol 26864-56-2
Pergolide mesylate 66104-23-2
PG 01037 dihydrochloride 675599-62-9
Phenothiazine 92-84-2
Piribedil dihydrochloride 1451048-94-4
PNU 177864 hydrochloride 250266-51-4
PNU 96415E 170856-41-4
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Prochlorperazine Dopamine (D2) receptor antagonist 1984-02-6
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Quinelorane hydrochloride 97548-97-5
Raclopride 84225-95-6
rac-Rotigotine Hydrochloride Agonist of dopamine D2/D3 receptor 102120-99-0
Remoxipride hydrochloride 73220-03-8
Ro 10-5824 dihydrochloride 189744-94-3
Ropinirole HCl 91374-20-8
Rotigotine Agonist of dopamine D2/D3 receptor 99755-59-6
Rotigotine hydrochloride Agonist of dopamine D2/D3 receptor 125572-93-2
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Roxindole hydrochloride 108050-82-4
RuBi-Dopa
SB 277011A dihydrochloride 1226917-67-4
SB269652 Dopamine D2 receptor modulator 215802-15-6
SB-277011 215803-78-4
SCH 23390 hydrochloride 125941-87-9
Sitaxentan sodium 210421-74-2
SKF 38393 hydrobromide 20012-10-6
SKF 77434 hydrobromide 300561-58-4
SKF 81297 hydrobromide 67287-39-2
SKF 83566 hydrobromide 108179-91-5
SKF 83822 hydrobromide 74115-10-9
SKF 83959 hydrobromide 67287-95-0
Sonepiprazole 170858-33-0
ST-836 Dopamine receptor ligand 1148156-63-1
ST-836 hydrochloride Dopamine receptor ligand 1415564-68-9
Sumanirole maleate Dopamine D2 agonist 179386-44-8
Talipexole 101626-70-4
Threo-methylphenidate hydrochloride 298-59-9
U 99194 maleate 234757-41-6
genes like me logo Genes that share compounds with DRD2: view

Drug Products

Transcripts for DRD2 Gene

Unigene Clusters for DRD2 Gene

Dopamine receptor D2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DRD2
  • R&D Systems cDNA Clones for DRD2 (Dopamine D2 R/DRD2)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRD2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - -
SP2: - -
SP3:
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for DRD2 Gene

GeneLoc Exon Structure for
DRD2
ECgene alternative splicing isoforms for
DRD2

Expression for DRD2 Gene

mRNA expression in normal human tissues for DRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRD2 Gene

This gene is overexpressed in Pituitary (x12.9), Brain - Putamen (basal ganglia) (x12.2), Brain - Nucleus accumbens (basal ganglia) (x9.7), and Brain - Caudate (basal ganglia) (x7.8).

Protein differential expression in normal tissues from HIPED for DRD2 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DRD2 Gene



Protein tissue co-expression partners for DRD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DRD2 Gene:

DRD2

SOURCE GeneReport for Unigene cluster for DRD2 Gene:

Hs.73893
genes like me logo Genes that share expression patterns with DRD2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DRD2 Gene

Orthologs for DRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD2 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia DRD2 34 35
  • 93.98 (n)
cow
(Bos Taurus)
Mammalia DRD2 34 35
  • 93 (n)
mouse
(Mus musculus)
Mammalia Drd2 34 16 35
  • 90.82 (n)
rat
(Rattus norvegicus)
Mammalia Drd2 34
  • 90.29 (n)
oppossum
(Monodelphis domestica)
Mammalia DRD2 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRD2 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRD2 34 35
  • 78.67 (n)
lizard
(Anolis carolinensis)
Reptilia DRD2 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493063 34
  • 69.6 (n)
zebrafish
(Danio rerio)
Actinopterygii drd2b 34 35
  • 68.89 (n)
drd2a 35
  • 67 (a)
OneToMany
drd2l 35
  • 56 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG7431 36
  • 39 (a)
5-HT2 36
  • 37 (a)
D2R 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-3 34 35
  • 48.47 (n)
dop-2 35
  • 17 (a)
ManyToMany
dop-6 35
  • 15 (a)
ManyToMany
C24A8.6 35
  • 12 (a)
ManyToMany
Species where no ortholog for DRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD2 Gene

ENSEMBL:
Gene Tree for DRD2 (if available)
TreeFam:
Gene Tree for DRD2 (if available)

Paralogs for DRD2 Gene

Paralogs for DRD2 Gene

genes like me logo Genes that share paralogs with DRD2: view

Variants for DRD2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DRD2 Gene

DRD2_HUMAN-P14416
Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.

Sequence variations from dbSNP and Humsavar for DRD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1799978 drug-response 113,475,629(-) AGCTT(A/G)TTACT nc-transcript-variant, upstream-variant-2KB
rs1800496 Likely benign 113,412,766(-) CCGAC(C/T)CGTCC reference, missense
rs1800499 Likely benign 113,416,972(-) ATGCT(A/G)TACAA reference, synonymous-codon
rs199523375 Likely benign 113,410,711(+) CTGTG(C/T)GGGCA utr-variant-3-prime
rs104894220 Uncertain significance 113,416,935(-) TCACC(A/G)TCATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DRD2 Gene

Variant ID Type Subtype PubMed ID
nsv1040152 CNV loss 25217958
nsv473342 CNV novel sequence insertion 20440878
nsv523683 CNV loss 19592680
nsv556444 CNV gain 21841781

Variation tolerance for DRD2 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRD2 Gene

Human Gene Mutation Database (HGMD)
DRD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRD2

Disorders for DRD2 Gene

MalaCards: The human disease database

(73) MalaCards diseases for DRD2 Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DRD2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DRD2

Genetic Association Database (GAD)
DRD2
Human Genome Epidemiology (HuGE) Navigator
DRD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRD2
genes like me logo Genes that share disorders with DRD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRD2 Gene

Publications for DRD2 Gene

  1. Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. (PMID: 16867246) Wu S.N. … He L. (Acta Pharmacol. Sin. 2006) 3 22 25 46 64
  2. Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. (PMID: 15694263) Wu S. … He L. (Neurosci. Lett. 2005) 3 22 25 46 64
  3. Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (PMID: 15389757) Johann M. … Wodarz N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005) 3 4 22 46 64
  4. Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (PMID: 10220438) Klein C. … Ozelius L.J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 22 46 64
  5. Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. (PMID: 20170711) Lohoff F.W. … Oslin D.W. (Neurosci. Lett. 2010) 3 22 46 64

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