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Aliases for DRD2 Gene

Aliases for DRD2 Gene

  • Dopamine Receptor D2 2 3
  • Dopamine D2 Receptor 3 4
  • Seven Transmembrane Helix Receptor 3
  • Dopamine Receptor D2 Isoform 3
  • D(2) Dopamine Receptor 3
  • D2DR 3
  • D2R 3

External Ids for DRD2 Gene

Previous GeneCards Identifiers for DRD2 Gene

  • GC11M115633
  • GC11M114792
  • GC11M112817
  • GC11M112785
  • GC11M109208
  • GC11M113280

Summaries for DRD2 Gene

Entrez Gene Summary for DRD2 Gene

  • This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD2 Gene

DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include dystonia-11, myoclonic and periodic limb movement disorder. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include identical protein binding and potassium channel regulator activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for DRD2 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Tocris Summary for DRD2 Gene

  • D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The human D2 receptor gene has been localized to chromosome 11 (11q22-23).

Gene Wiki entry for DRD2 Gene

PharmGKB "VIP" Summary for DRD2 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for DRD2 Gene

Genomics for DRD2 Gene

Regulatory Elements for DRD2 Gene

Genomic Location for DRD2 Gene

Start:
113,409,595 bp from pter
End:
113,475,691 bp from pter
Size:
66,097 bases
Orientation:
Minus strand

Genomic View for DRD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD2 Gene

Proteins for DRD2 Gene

  • Protein details for DRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14416-DRD2_HUMAN
    Recommended name:
    D(2) dopamine receptor
    Protein Accession:
    P14416
    Secondary Accessions:
    • Q9NZR3
    • Q9UPA9

    Protein attributes for DRD2 Gene

    Size:
    443 amino acids
    Molecular mass:
    50619 Da
    Quaternary structure:
    • Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI1 (PubMed:17264214). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.

    Three dimensional structures from OCA and Proteopedia for DRD2 Gene

    Alternative splice isoforms for DRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRD2 Gene

Proteomics data for DRD2 Gene at MOPED

Post-translational modifications for DRD2 Gene

  • Glycosylation at Asn5, Asn17, and Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD2 Gene

No data available for DME Specific Peptides for DRD2 Gene

Domains for DRD2 Gene

Gene Families for DRD2 Gene

HGNC:
  • DRD :GPCR / Class A : Dopamine receptors
IUPHAR :

Suggested Antigen Peptide Sequences for DRD2 Gene

Graphical View of Domain Structure for InterPro Entry

P14416

UniProtKB/Swiss-Prot:

DRD2_HUMAN :
  • P14416
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD2: view

Function for DRD2 Gene

Molecular function for DRD2 Gene

GENATLAS Biochemistry: dopamine receptor D2 (two isoforms),adenylate cyclase inhibiting,G protein coupled receptor superfamily,expressed in the basal ganglia (contradictory evidence for association of the S311C variant with schizophrenia),regulated by DNA methylation,involved in the regulation of appetite and growth hormone
UniProtKB/Swiss-Prot Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA 2531656
GO:0004930 G-protein coupled receptor activity --
GO:0004952 dopamine neurotransmitter receptor activity --
GO:0005102 receptor binding --
GO:0005515 protein binding IPI 10692483
genes like me logo Genes that share ontologies with DRD2: view
genes like me logo Genes that share phenotypes with DRD2: view

Animal Models for DRD2 Gene

MGI Knock Outs for DRD2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DRD2 Gene

Localization for DRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD2 Gene COMPARTMENTS Subcellular localization image for DRD2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 8413587
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with DRD2: view

Pathways for DRD2 Gene

genes like me logo Genes that share pathways with DRD2: view

Gene Ontology (GO) - Biological Process for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis ISS --
GO:0001666 response to hypoxia IEA --
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0001964 startle response --
GO:0001975 response to amphetamine ISS --
genes like me logo Genes that share ontologies with DRD2: view

Compounds for DRD2 Gene

(5) Tocris Compounds for DRD2 Gene

Compound Action Cas Number
L-741,626 High affinity D2 antagonist [81226-60-0]
PAOPA Dopamine D2 receptor allosteric modulator [114200-31-6]
Prochlorperazine dimaleate D2 receptor antagonist. Also 5-HT3 and nAChR antagonist [84-02-6]
Rotigotine hydrochloride Dopamine D2/D3 agonist [125572-93-2]
Sumanirole maleate D2-selective agonist [179386-44-8]

(5) HMDB Compounds for DRD2 Gene

Compound Synonyms Cas Number PubMed IDs
Aripiprazole
  • Abilify
129722-12-9
Dopamine
  • 2-(3,4-Dihydroxyphenyl)ethylamine
62-31-7
Olanzapine
  • Lanzac
132539-06-1
Quetiapine
  • Quetiapine fumarate
111974-69-7
Risperidone
  • Belivon
106266-06-2

(68) Drugbank Compounds for DRD2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acepromazine
  • 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
61-00-7 target antagonist
Acetophenazine
2751-68-0 target antagonist
Alizapride
  • Alizaprida [inn-spanish]
59338-93-1 target antagonist
Amantadine
  • 1-aminoadamantane
768-94-5 target agonist
Amisulpride
53583-79-2 target antagonist

(36) IUPHAR Ligand for DRD2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]nemonapride Antagonist Antagonist 10.9
eticlopride Antagonist Antagonist 9.2
(-)-N-porphynorapomorphine Agonist Full agonist 8.9
terguride Antagonist Antagonist 8.9
roxindole Antagonist Antagonist 8.6
(+)-butaclamol Antagonist Antagonist 8.5
nafadotride Antagonist Antagonist 8.5
domperidone Antagonist Antagonist 8.4
cis flupentixol Antagonist Antagonist 8.4
(+)-sulpiride Antagonist Antagonist 8.22
sumanirole Agonist Full agonist 8.1
amisulpride Antagonist Antagonist 8
(-)-sulpiride Antagonist Antagonist 8
raclopride Antagonist Antagonist 8
sulpiride Antagonist Antagonist 7.92
quinpirole Agonist Full agonist 7.7
7-OH-DPAT Agonist Full agonist 7.6
pramipexole Agonist Full agonist 7.4
lisuride Agonist Partial agonist 7.2
(+)-UH232 Antagonist Antagonist 7.1
piribedil Agonist Partial agonist 6.9
cabergoline Agonist Full agonist 6.7
clozapine Antagonist Antagonist 6.7
pergolide Agonist Full agonist 6.5
PD 128907 Agonist Full agonist 6.4
pimozide Antagonist Antagonist 6.2
bromocriptine Agonist Partial agonist 6.2
haloperidol Antagonist Antagonist 6.1
trans flupenthixol Antagonist Antagonist 6
quinelorane Agonist Full agonist 5.7
dopamine Agonist Full agonist 5.6
7-trans-OH-PIPAT Agonist Full agonist 5.6
(+)-S-14297 Antagonist Antagonist 5.5
(+)-SCH-23390 Antagonist Antagonist 5.3
apomorphine Activator Activation 5.1
chlorpromazine Channel blocker None

(107) Novoseek inferred chemical compound relationships for DRD2 Gene

Compound -log(P) Hits PubMed IDs
dopamine 93 175
ibzm 90.6 29
raclopride 84.4 24
quinpirole 83.9 32
haloperidol 82.6 80

(10) PharmGKB related drug/compound annotations for DRD2 Gene

genes like me logo Genes that share compounds with DRD2: view

Transcripts for DRD2 Gene

Unigene Clusters for DRD2 Gene

Dopamine receptor D2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRD2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - -
SP2: - -
SP3:
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for DRD2 Gene

GeneLoc Exon Structure for
DRD2
ECgene alternative splicing isoforms for
DRD2

Expression for DRD2 Gene

mRNA expression in normal human tissues for DRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRD2 Gene

This gene is overexpressed in Pituitary (12.9), Brain - Putamen (basal ganglia) (12.2), Brain - Nucleus accumbens (basal ganglia) (9.7), and Brain - Caudate (basal ganglia) (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DRD2 Gene

SOURCE GeneReport for Unigene cluster for DRD2 Gene Hs.73893

genes like me logo Genes that share expressions with DRD2: view

No data available for mRNA Expression by UniProt/SwissProt for DRD2 Gene

Orthologs for DRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD2 35
  • 99.7 (n)
  • 99.77 (a)
DRD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRD2 35
  • 93 (n)
  • 96.61 (a)
DRD2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRD2 35
  • 93.98 (n)
  • 96.39 (a)
DRD2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd2 35
  • 90.82 (n)
  • 95.71 (a)
Drd2 16
Drd2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRD2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRD2 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd2 35
  • 90.29 (n)
  • 95.94 (a)
chicken
(Gallus gallus)
Aves DRD2 35
  • 78.67 (n)
  • 81.19 (a)
DRD2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493063 35
  • 69.6 (n)
  • 78.47 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
drd2a 36
  • 67 (a)
OneToMany
drd2b 35
  • 68.89 (n)
  • 71.43 (a)
drd2b 36
  • 69 (a)
OneToMany
drd2l 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta D2R 36
  • 25 (a)
OneToMany
CG7431 37
  • 39 (a)
5-HT2 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea C24A8.6 36
  • 12 (a)
ManyToMany
dop-2 36
  • 17 (a)
ManyToMany
dop-3 35
  • 48.47 (n)
  • 44.44 (a)
dop-3 36
  • 23 (a)
ManyToMany
dop-6 36
  • 15 (a)
ManyToMany
Species with no ortholog for DRD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD2 Gene

ENSEMBL:
Gene Tree for DRD2 (if available)
TreeFam:
Gene Tree for DRD2 (if available)

Paralogs for DRD2 Gene

Paralogs for DRD2 Gene

Pseudogenes.org Pseudogenes for DRD2 Gene

genes like me logo Genes that share paralogs with DRD2: view

Variants for DRD2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DRD2 Gene

P14416-DRD2_HUMAN
Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics

Sequence variations from dbSNP and Humsavar for DRD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6273 -- 113,409,801(-) CTCCT(A/G/T)TTTCC utr-variant-3-prime
rs6274 -- 113,410,206(-) GCAGG(A/G/T)TGGAC utr-variant-3-prime
rs6275 -- 113,412,755(-) CACCA(C/T)GGTCT synonymous-codon, reference
rs6276 -- 113,410,675(-) AGGCC(A/G)GCCAG utr-variant-3-prime
rs6277 -- 113,412,737(-) ACTCC(C/T)GACAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DRD2 Gene

Variant ID Type Subtype PubMed ID
nsv898394 CNV Loss 21882294
nsv523683 CNV Loss 19592680

Relevant External Links for DRD2 Gene

HapMap Linkage Disequilibrium report
DRD2
Human Gene Mutation Database (HGMD)
DRD2

Disorders for DRD2 Gene

(1) OMIM Diseases for DRD2 Gene (126450)

UniProtKB/Swiss-Prot

DRD2_HUMAN
  • Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. {ECO:0000269 PubMed:10220438}. Note=The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258). {ECO:0000269 PubMed:10716258}.

(92) Novoseek inferred disease relationships for DRD2 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 83.9 163
alcoholism 77.1 196
parkinson disease 72.4 88
prolactinoma 69.2 16
parkinsonism 65 20

Relevant External Links for DRD2

GeneTests
DRD2
GeneReviews
DRD2
Genetic Association Database (GAD)
DRD2
Human Genome Epidemiology (HuGE) Navigator
DRD2
genes like me logo Genes that share disorders with DRD2: view

Publications for DRD2 Gene

  1. Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (PMID: 10220438) Klein C. … Ozelius L.J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23 48
  2. Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (PMID: 15389757) Johann M. … Wodarz N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005) 3 4 23 48
  3. Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function. (PMID: 15140279) Lane H.Y. … Chang W.H. (Int. J. Neuropsychopharmacol. 2004) 3 23 25 48
  4. Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. (PMID: 15694263) Wu S. … He L. (Neurosci. Lett. 2005) 3 23 25 48
  5. DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. (PMID: 16513877) Lencz T. … Malhotra A.K. (Am J Psychiatry 2006) 3 23 25 48

Products for DRD2 Gene

Sources for DRD2 Gene

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