DRD2 Gene
protein-coding GIFtS: 69
GCID: GC11M113280
|
|
dopamine receptor D2
| |
Aliases
for DRD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dopamine Receptor D21 2 | | D(2) Dopamine Receptor2 | | Dopamine D2 Receptor2 3 | | Dopamine Receptor D2 Isoform2 | | D2DR2 | | Seven Transmembrane Helix Receptor2 | | D2R2 | | |
Export aliases for DRD2 gene to outside databasesPrevious GC identifers: GC11M115633 GC11M114792 GC11M113314 GC11M112817 GC11M112785 GC11M109208 |
Summaries
for DRD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DRD2:
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclaseactivity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated withschizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Athird variant has been described, but it has not been determined whether this form is normal or due to aberrantsplicing. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)
 summary
for DRD2: D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1,
D3, D4 and D5. They are located primarily in the caudate putamen, nucleus accumbens and olfactory tubercle
where they are involved in the modulation of locomotion, reward, reinforcement and memory and learning. The
human D2 receptor gene has been localized to chromosome 11 (11q22-23).
Gene Wiki entry for DRD2 (Dopamine receptor D2)
PharmGKB "VIP" summary for
DRD2
|
Genomic Views
for DRD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DRD2 gene promoter:
CREB GR Sp1 p300 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for DRD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q22-q23DRD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M113280: view genomic region
(about GC identifiers)
Start:
|
113,280,317 bp from pter |
End:
|
113,346,413 bp from pter |
Size:
|
66,097 bases |
Orientation:
|
minus strand |
|
Proteins
for DRD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416 (See
protein sequence)Recommended Name: D(2) dopamine receptor Size: 443 amino acids; 50619 Da
Subunit: Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstreamsignaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts withARRB2 (By similarity). Interacts with GNAI1. Interacts with GNAI2 isoform sGi2, the interaction allows the creation ofan intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from  and Proteopedia  for DRD2:1I15 (3D)
Secondary accessions: Q9NZR3 Q9UPA9Alternative splicing: 3 isoforms: P14416-1 P14416-2 P14416-3 Explore the universe of human proteins at neXtProt for DRD2: NX_P14416
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P14416
DRD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000786.1 NP_057658.2
ENSEMBL proteins: ENSP00000278597 ENSP00000354859 ENSP00000441068 ENSP00000442172 ENSP00000438215 ENSP00000438419 ENSP00000441474 ENSP00000347474 Reactome Protein details: P14416
Human Recombinant Protein Products:
Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17): About this table
DRD2 for ontologies About GeneDecksing
DRD2 Antibody Products:
Assay Products for DRD2: |
Protein
Domains /
Families
for DRD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DRD2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P14416ProtoNet protein and cluster: P14416 2 Blocks protein families: IPB000929 Dopamine receptor signature IPB001922 Dopamine D2 receptor signature
UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for DRD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) Genatlas biochemistry entry for DRD2:dopamine receptor D2 (two isoforms),adenylate cyclase inhibiting,G protein coupled receptor superfamily,expressed inthe basal ganglia (contradictory evidence for association of the S311C variant with schizophrenia),regulated by DNAmethylation,involved in the regulation of appetite and growth hormone
Clone
Products: |  | EMD Millipore Clones for the Expression of DRD2 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DRD2 (NM_000795) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DRD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD2 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
DRD2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for DRD2: Drd2tm2Ebo Drd2tm1Low Drd2tm1.2Mrub Drd2tm1Yyw Drd2tm1Mok Drd2tm1Schm
Drd2tm1Ebo
15/24 MGI mutant phenotypes (inferred from 10 alleles ) (MGI details for Drd2) (see all 24):
DRD2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DRD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Development_Dopamine D2 receptor transactivation of EGFR | | | 4 | Signaling in Gap Junctions | | | 5 | Monoamine GPCRs | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DRD2
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DRD2
1  GeneGo (Thomson Reuters) Pathway for DRD2
4  BioSystems Pathways for DRD2
5/8 
Reactome Pathways for DRD2 (see all 8)
1  PharmGKB Pathway for DRD2
2 
Kegg Pathways (Kegg details for DRD2):
DRD2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DRD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/172 Interacting proteins for DRD2 (P144161, 2, 3 ENSP000003548594) via UniProtKB, MINT, STRING, and/or I2D (see all 172)About this table
Gene Ontology (GO): 5/91 biological process terms (GO ID links to tree view) (see all 91): About this table
DRD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DRD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DRD2 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for DRD2 |
Compounds for DRD2 available from Tocris Bioscience About this table
5 HMDB Compounds for DRD2 About this table
10/64 DrugBank Compounds for DRD2 (see all 64) About this table
10/107 Novoseek chemical compound relationships for DRD2 gene (see all 107) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dopamine |
93 |
842 |
8242725 (4), 18363853 (3), 8208404 (3), 16766383 (3) (see all 99) |
| ibzm |
90.6 |
29 |
9046079 (4), 9613734 (2), 16259998 (2), 7984527 (2) (see all 23) |
| raclopride |
84.4 |
25 |
1365855 (2), 7753373 (1), 7790956 (1), 1978494 (1) (see all 23) |
| quinpirole |
83.9 |
35 |
7957635 (1), 15857393 (1), 17179741 (1), 19298320 (1) (see all 32) |
| haloperidol |
82.6 |
87 |
1533719 (3), 7566476 (2), 1978483 (2), 11697576 (2) (see all 69) |
| (11c)-n-methylspiperone |
81.6 |
16 |
10647606 (3), 7909948 (2), 17413189 (1), 7480390 (1) (see all 10) |
| remoxipride |
80.4 |
23 |
1978494 (4), 1978483 (2), 11607043 (2), 8153056 (1) (see all 17) |
| clozapine |
80 |
64 |
16040180 (7), 7542051 (4), 16738543 (2), 9577836 (2) (see all 47) |
| 2'-iodospiperone |
79.7 |
9 |
8534585 (3), 7790943 (3), 1399682 (1) |
| bromocriptine |
79.5 |
46 |
20138024 (2), 8012964 (2), 9134209 (2), 8951172 (1) (see all 37) |
9 PharmGKB related drug/compound annotations for DRD2 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about DRD2
|
Transcripts
for DRD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DRD2 gene (2 alternative transcripts): NM_000795.3 NM_016574.3 Unigene Cluster for DRD2: Dopamine receptor D2 Hs.73893 [show with all ESTs]Unigene Representative Sequence: NM_00079511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000346454 ENST00000362072 ENST00000544518 ENST00000542968 ENST00000538967
ENST00000540600(uc009yyr.1) ENST00000535984 ENST00000539420 ENST00000543292
ENST00000542616 ENST00000355319(uc010rwv.2 uc001pnz.3 uc001poa.4 uc001pob.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DRD2 (NM_000795) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DRD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD2 |
Additional cDNA sequence: AB209832.1 AB451480.1 AF176812.1 AK308777.1 BC021195.2 M29066.1 M30625.1 S62137.1 S69899.1 X51362.1 X51645.1 5 DOTS entries: DT.91757826 DT.99961527 DT.97836669 DT.91757824 DT.100775079 24/34 AceView cDNA sequences (see all 34): BE795107 BC021195 NM_016574 AI369867 NM_000795 BX283073 BG827135 M29066 BE266564 BE798784 BF311952 BM685017 BQ719305 BQ879192 BV203633 X51645 AF176812 AA316796 AI732883 BM931977 BF311583 BI195997 S62137 S69899
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DRD2 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DRD2
|
Expression
for DRD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DRD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCAAACTA
About this image
See DRD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DRD2
SOURCE GeneReport for Unigene cluster: Hs.73893
SABiosciences Expression via Pathway-Focused PCR Arrays including DRD2 (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DRD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DRD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD2 |
Orthologs
for DRD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DRD2 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DRD21 |
dopamine receptor D2 |
78.59(n)
81.42(a) |
|
428252 NM_001113290.1 NP_001106761.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DRD26 |
-- |
77(a) |
1 ↔ 1 |
GL343354.1(451491-460712) |
African clawed frog
(Xenopus laevis) |
Amphibia |
X59500.12 |
-- |
75.34(n) |
|
X59500.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AY333792.12 |
-- |
78.23(n) |
|
378719 AY333792.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG74313 |
G-protein coupled receptor protein signaling
pathway more |
39(a)
(best of 2) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
dop-31 |
Protein DOP-3 |
49.27(n)
45.76(a) |
|
188499 NM_001029737.2 NP_001024908.2 |
ENSEMBL Gene Tree for DRD2 (if available)
TreeFam Gene Tree for DRD2 (if available) |
Paralogs
for DRD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DRD2 gene
- DRD42 HTR1A2 ADRA1B2 HTR1F2 HTR72 ADRA2C2 ADRA2A2 HTR1D2
- ADRA2B2 ADRA1A2 HTR1E2 DRD32 HTR5A2 HTR1B2 ADRA1D2
18/32 SIMAP similar genes for DRD2 using alignment to 4 protein entries: DRD2_HUMAN (see all proteins)
(see all similar genes):DRD3 CHRM1 HRH3 HTR4 ADRB3 hA2aR
CHRM5 ADORA2A alpha 1c-adrenoceptor subtype TAAR2 ADRA1A QRFPR
DRD1 GPR19 HCRTR1 5HT1A HTR1A GPR63
DRD2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DRD2
PGOHUM00000259095
|
Genomic Variants
for DRD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416Polymorphism: Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Geneticvariations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be arisk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism andmight contribute to suicide risk in alcoholics
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DRD2 (113280317 - 113346413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DRD2: --
Human Gene Mutation Database (HGMD): DRD2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DRD2 |
|
Disorders
/ Diseases
for DRD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DRD2 for disorders About GeneDecksing
OMIM gene information: 126450
OMIM disorders: 159900
UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416
Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsivedystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary musclecontractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonicmovements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of bodyinvolvement, presence of myoclonus and response to alcohol are all variable
20/145  diseases for DRD2 (see all 145): About MalaCardsmyoclonus-dystonia periodic limb movement disorder myoclonus gilles de la tourette syndrome
obsessive-compulsive disorder post-traumatic stress disorder novelty seeking personality dopa-responsive dystonia
attention deficit hyperactivity disorder manic-depressive illness antisocial personality disorder schizophrenia
restless legs syndrome supranuclear palsy diffuse large b-cell lymphoma striatonigral degeneration
migraine without aura complex regional pain syndrome neuroleptic malignant syndrome leptin receptor deficiency
19 diseases from the University of Copenhagen DISEASES database for DRD2:Schizophrenia Parkinson's disease Alcohol dependence Substance abuse
Nicotine dependence Pathological gambling Cocaine dependence Attention deficit hyperactivity disorder
Antisocial personality disorder Neuroleptic malignant syndrome Hyperprolactinemia Movement disease
Heroin dependence Migraine Huntington's disease Schizoaffective disorder
Delusional disorder Pituitary adenoma Adenoma 10/92 Novoseek disease relationships for DRD2 gene (see all 92) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
83.9 |
339 |
2069495 (6), 8439241 (5), 17207969 (4), 18332877 (4) (see all 99) |
| alcoholism |
77.1 |
297 |
10235293 (6), 11236830 (5), 8871803 (5), 17850642 (5) (see all 99) |
| parkinson disease |
72.4 |
103 |
10647606 (4), 10990520 (4), 8489408 (3), 8543941 (3) (see all 65) |
| prolactinoma |
69.2 |
19 |
7907340 (2), 12552124 (2), 7641411 (1), 12972179 (1) (see all 14) |
| parkinsonism |
65 |
20 |
9452320 (1), 8534585 (1), 11993184 (1), 10416511 (1) (see all 20) |
| hyperprolactinemia |
64.4 |
16 |
16169407 (5), 19339912 (3), 19896213 (1), 12704865 (1) (see all 9) |
| catalepsy |
63.8 |
11 |
1975782 (1), 1358127 (1), 7901761 (1), 10958084 (1) (see all 9) |
| extrapyramidal syndrome |
61.2 |
7 |
9949416 (2), 11606886 (1), 8103229 (1), 16867246 (1) |
| psychotic |
60.6 |
19 |
10208638 (1), 11765615 (1), 15952869 (1), 7771917 (1) (see all 19) |
| schizoaffective disorder |
59.6 |
2 |
8439241 (1), 18786813 (1) |
GeneTests: DRD2
Myoclonus-Dystonia
Genetic Association Database (GAD): DRD2
Human Genome Epidemiology (HuGE) Navigator: DRD2 (863 documents)
Export disorders for DRD2 gene to outside databases
|
Publications
for DRD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DRD2 gene, integrated from 9 sources (see all 2062):
(articles sorted by number of sources associating them with DRD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (PubMed id 10220438)1, 2, 4, 9 Klein C.... Ozelius L.J. (1999)
- Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function. (PubMed id 15140279)1, 4, 7, 9 Lane H.Y....Chang W.H. (2004)
- Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. (PubMed id 15084894)1, 4, 9 Huang S.Y....Lu R.B. (2004)
- Dopamine D2 receptor gene (DRD2) is associated with alcoholism with conduct disorder. (PubMed id 11236830)1, 4, 9 Lu R.B....Lin W.W. (2001)
- Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients. (PubMed id 11343878)1, 4, 9 Dubertret C....Ades J. (2001)
- Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. (PubMed id 16867246)1, 7, 9 Wu S.N....He L. (2006)
- Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (PubMed id 15389757)1, 2, 9 Johann M.... Wodarz N. (2005)
- Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders. (PubMed id 11857579)1, 4, 9 Massat I....Mendlewicz J. (2002)
- A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys). (PubMed id 7902708)1, 2, 9 Itokawa M.... Toru M. (1993)
- A polymorphism of DRD2 gene and brain atrophy in methamphetamine psychosis. (PubMed id 15542731)1, 4, 9 Harano M....Ujike H. (2004)
|
External Searches for DRD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing DRD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing DRD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DRD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DRD2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DRD2 |
|
| | |
About This Section
| Patent Information for DRD2 gene:
Search GeneIP for patents involving DRD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DRD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DRD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DRD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DRD2 | | | OriGene Protein Over-expression Lysate for DRD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DRD2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD2 |
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