External Ids for DRD1 Gene
Previous GeneCards Identifiers for DRD1 Gene
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD1 Gene
DRD1 (Dopamine Receptor D1) is a Protein Coding gene. Diseases associated with DRD1 include cerebral meningioma and pathological gambling. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Amphetamine addiction. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is TAAR9.
UniProtKB/Swiss-Prot for DRD1 Gene
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.