Aliases for DRD1 Gene
External Ids for DRD1 Gene
Previous GeneCards Identifiers for DRD1 Gene
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD1 Gene
DRD1 (Dopamine Receptor D1) is a Protein Coding gene. Diseases associated with DRD1 include cerebral meningioma and transient cerebral ischemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include dopamine binding and dopamine neurotransmitter receptor activity, coupled via Gs. An important paralog of this gene is TAAR9.
UniProtKB/Swiss-Prot for DRD1 Gene
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1 receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution (mainly limbic areas).