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Aliases for DRD1 Gene

Aliases for DRD1 Gene

  • Dopamine Receptor D1 2 3 5
  • Dopamine D1 Receptor 3 4
  • DRD1A 3
  • DADR 3

External Ids for DRD1 Gene

Previous GeneCards Identifiers for DRD1 Gene

  • GC05M175180
  • GC05M175606
  • GC05M174803
  • GC05M174848
  • GC05M174800
  • GC05M169967

Summaries for DRD1 Gene

Entrez Gene Summary for DRD1 Gene

  • This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD1 Gene

DRD1 (Dopamine Receptor D1) is a Protein Coding gene. Diseases associated with DRD1 include cerebral meningioma and pathological gambling. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for DRD1 Gene

  • Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for DRD1 Gene

  • D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.

Gene Wiki entry for DRD1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD1 Gene

Genomics for DRD1 Gene

Regulatory Elements for DRD1 Gene

Promoters for DRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DRD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DRD1 Gene

Chromosome:
5
Start:
175,440,039 bp from pter
End:
175,444,208 bp from pter
Size:
4,170 bases
Orientation:
Minus strand

Genomic View for DRD1 Gene

Genes around DRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD1 Gene

Proteins for DRD1 Gene

  • Protein details for DRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21728-DRD1_HUMAN
    Recommended name:
    D(1A) dopamine receptor
    Protein Accession:
    P21728
    Secondary Accessions:
    • B2RA44
    • Q4QRJ0

    Protein attributes for DRD1 Gene

    Size:
    446 amino acids
    Molecular mass:
    49293 Da
    Quaternary structure:
    • Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.

    Three dimensional structures from OCA and Proteopedia for DRD1 Gene

neXtProt entry for DRD1 Gene

Proteomics data for DRD1 Gene at MOPED

Post-translational modifications for DRD1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for DRD1 (Dopamine D1 R/DRD1)

No data available for DME Specific Peptides for DRD1 Gene

Domains & Families for DRD1 Gene

Gene Families for DRD1 Gene

Suggested Antigen Peptide Sequences for DRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21728

UniProtKB/Swiss-Prot:

DRD1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD1: view

Function for DRD1 Gene

Molecular function for DRD1 Gene

GENATLAS Biochemistry:
dopamine receptor D1,mainly expressed in hypophysis and parathyroid in ovary and granulosa luteal cells,adenylate cyclase stimulating,G protein coupled receptor superfamily,involved in the control of vascular tone
UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0005515 protein binding IEA,IPI 15569306
genes like me logo Genes that share ontologies with DRD1: view
genes like me logo Genes that share phenotypes with DRD1: view

Animal Models for DRD1 Gene

MGI Knock Outs for DRD1:

Animal Model Products

miRNA for DRD1 Gene

miRTarBase miRNAs that target DRD1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRD1 Gene

Localization for DRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD1 Gene COMPARTMENTS Subcellular localization image for DRD1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
endoplasmic reticulum 3
nucleus 3
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IC 2144334
GO:0030425 dendrite IEA --
GO:0044327 dendritic spine head IEA --
GO:0060170 ciliary membrane IDA 20531939
genes like me logo Genes that share ontologies with DRD1: view

Pathways & Interactions for DRD1 Gene

genes like me logo Genes that share pathways with DRD1: view

Interacting Proteins for DRD1 Gene

Selected Interacting proteins: P21728-DRD1_HUMAN for DRD1 Gene via I2D

Gene Ontology (GO) - Biological Process for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0001662 behavioral fear response IEA --
GO:0001963 synaptic transmission, dopaminergic IEA,IBA --
GO:0001975 response to amphetamine IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with DRD1: view

No data available for SIGNOR curated interactions for DRD1 Gene

Drugs & Compounds for DRD1 Gene

(132) Drugs for DRD1 Gene - From: Novoseek, IUPHAR, DGIdb, DrugBank, HMDB, ApexBio, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Dopamine Approved Pharma Full agonist, Agonist, agonist, Target, Target 3084
Haloperidol Approved Pharma Antagonist, antagonist, Target Antipsychotic drug 136
Pergolide Approved, Withdrawn Pharma Partial agonist, Agonist, agonist, Target 12
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 34

(37) Additional Compounds for DRD1 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-HT
Full agonist, Agonist
cis flupentixol
Antagonist
NPA
Full agonist, Agonist
SKF-82526
Full agonist, Agonist
Promazine 5-sulfoxide

(5) Tocris Compounds for DRD1 Gene

Compound Action Cas Number
A 68930 hydrochloride Potent, selective D1-like agonist 130465-39-3
CY 208-243 Selective D1-like agonist 100999-26-6
Dihydrexidine hydrochloride Selective D1-like agonist 158704-02-0
SKF 38393 hydrobromide Selective D1-like agonist 20012-10-6
SKF 81297 hydrobromide D1 agonist 67287-39-2

(26) ApexBio Compounds for DRD1 Gene

Compound Action Cas Number
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Aripiprazole Antipsychotic 129722-12-9
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Haloperidol Antipsychotic drug 52-86-8
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Metoclopramide Dopamine receptor antagonist 364-62-5
Paliperidone 144598-75-4
PD128907 HCl 112960-16-4
Pergolide mesylate 66104-23-2
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Sitaxentan sodium 210421-74-2
genes like me logo Genes that share compounds with DRD1: view

Drug Products

Transcripts for DRD1 Gene

mRNA/cDNA for DRD1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD1 Gene

Dopamine receptor D1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRD1 Gene

No ASD Table

Relevant External Links for DRD1 Gene

GeneLoc Exon Structure for
DRD1
ECgene alternative splicing isoforms for
DRD1

Expression for DRD1 Gene

mRNA expression in normal human tissues for DRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.4), Brain - Caudate (basal ganglia) (x13.8), and Brain - Putamen (basal ganglia) (x12.5).

SOURCE GeneReport for Unigene cluster for DRD1 Gene Hs.2624

mRNA Expression by UniProt/SwissProt for DRD1 Gene

P21728-DRD1_HUMAN
Tissue specificity: Detected in caudate, nucleus accumbens and in the olfactory tubercle.
genes like me logo Genes that share expression patterns with DRD1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DRD1 Gene

Orthologs for DRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DRD1 35
  • 91.03 (n)
  • 94.39 (a)
DRD1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRD1 35
  • 91.85 (n)
  • 95.52 (a)
DRD1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd1a 35
  • 87.1 (n)
  • 91.86 (a)
Drd1 16
Drd1a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DRD1 35
  • 99.85 (n)
  • 100 (a)
DRD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd1 35
  • 85.97 (n)
  • 90.95 (a)
oppossum
(Monodelphis domestica)
Mammalia DRD1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRD1 35
  • 77.48 (n)
  • 82.66 (a)
D1A 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drd1 35
  • 72.22 (n)
  • 81.53 (a)
zebrafish
(Danio rerio)
Actinopterygii drd1b 35
  • 70.1 (n)
  • 75.18 (a)
CT025914.2 36
  • 76 (a)
OneToMany
drd1b 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 39 (a)
CG6989 37
  • 34 (a)
DopR 37
  • 39 (a)
DopR 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-1 36
  • 29 (a)
OneToMany
Species with no ortholog for DRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD1 Gene

ENSEMBL:
Gene Tree for DRD1 (if available)
TreeFam:
Gene Tree for DRD1 (if available)

Paralogs for DRD1 Gene

Paralogs for DRD1 Gene

genes like me logo Genes that share paralogs with DRD1: view

Variants for DRD1 Gene

Sequence variations from dbSNP and Humsavar for DRD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs5327 - 175,442,991(-) TGTCC(A/C/G)CGCTC reference, missense
VAR_014671 -
rs5330 - 175,442,950(-) ATCAG(A/G/T)TTCCG reference, synonymous-codon, missense
rs5331 - 175,442,505(-) CATCC(G/T)CTGTA reference, missense
VAR_064577 -

Variation tolerance for DRD1 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRD1 Gene

HapMap Linkage Disequilibrium report
DRD1
Human Gene Mutation Database (HGMD)
DRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DRD1 Gene

Disorders for DRD1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for DRD1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebral meningioma
  • meningioma of cerebrum
pathological gambling
  • compulsive gambling
early-onset schizophrenia
  • early onset schizophrenia
bipolar i disorder
striatonigral degeneration
- elite association - COSMIC cancer census association via MalaCards
Search DRD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DRD1

Genetic Association Database (GAD)
DRD1
Human Genome Epidemiology (HuGE) Navigator
DRD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRD1
genes like me logo Genes that share disorders with DRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRD1 Gene

Publications for DRD1 Gene

  1. A haplotype of the DRD1 gene is associated with alcohol dependence. (PMID: 18341651) Batel P. … Gorwood P. (Alcohol. Clin. Exp. Res. 2008) 3 23 48 67
  2. Dopamine genes and pathological gambling in discordant sib-pairs. (PMID: 17394052) da Silva Lobo D.S. … Kennedy J.L. (J Gambl Stud 2007) 3 23 25 26
  3. Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. (PMID: 17455212) Dolzan V. … Breskvar K. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 25 26
  4. Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations. (PMID: 17468175) Fu W. … Jiang H. (Biophys. J. 2007) 23 25 26
  5. The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. (PMID: 17301410) Ostadali M.R. … Boulhari J. (Iran J Allergy Asthma Immunol 2004) 23 25 26

Products for DRD1 Gene

Sources for DRD1 Gene

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