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Aliases for DRD1 Gene

Aliases for DRD1 Gene

  • Dopamine Receptor D1 2 3
  • Dopamine D1 Receptor 3 4
  • D(1A) Dopamine Receptor 3
  • DRD1A 3
  • DADR 3

External Ids for DRD1 Gene

Previous GeneCards Identifiers for DRD1 Gene

  • GC05M175180
  • GC05M175606
  • GC05M174803
  • GC05M174848
  • GC05M174800
  • GC05M169967

Summaries for DRD1 Gene

Entrez Gene Summary for DRD1 Gene

  • This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD1 Gene

DRD1 (Dopamine Receptor D1) is a Protein Coding gene. Diseases associated with DRD1 include cerebral meningioma and transient cerebral ischemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include dopamine binding and dopamine neurotransmitter receptor activity, coupled via Gs. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for DRD1 Gene

  • Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

Tocris Summary for DRD1 Gene

  • D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1 receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution (mainly limbic areas).

Gene Wiki entry for DRD1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD1 Gene

Genomics for DRD1 Gene

Regulatory Elements for DRD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DRD1 Gene

Start:
175,440,039 bp from pter
End:
175,444,208 bp from pter
Size:
4,170 bases
Orientation:
Minus strand

Genomic View for DRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD1 Gene

Proteins for DRD1 Gene

  • Protein details for DRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21728-DRD1_HUMAN
    Recommended name:
    D(1A) dopamine receptor
    Protein Accession:
    P21728
    Secondary Accessions:
    • B2RA44
    • Q4QRJ0

    Protein attributes for DRD1 Gene

    Size:
    446 amino acids
    Molecular mass:
    49293 Da
    Quaternary structure:
    • Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.

    Three dimensional structures from OCA and Proteopedia for DRD1 Gene

neXtProt entry for DRD1 Gene

Proteomics data for DRD1 Gene at MOPED

Post-translational modifications for DRD1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DRD1 Gene

Domains for DRD1 Gene

Gene Families for DRD1 Gene

HGNC:
  • DRD :GPCR / Class A : Dopamine receptors
IUPHAR :

Suggested Antigen Peptide Sequences for DRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21728

UniProtKB/Swiss-Prot:

DRD1_HUMAN :
  • P21728
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD1: view

Function for DRD1 Gene

Molecular function for DRD1 Gene

GENATLAS Biochemistry: dopamine receptor D1,mainly expressed in hypophysis and parathyroid in ovary and granulosa luteal cells,adenylate cyclase stimulating,G protein coupled receptor superfamily,involved in the control of vascular tone
UniProtKB/Swiss-Prot Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO) - Molecular Function for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IMP 1282671
GO:0004930 G-protein coupled receptor activity --
GO:0004952 dopamine neurotransmitter receptor activity IDA 1831904
GO:0005515 protein binding IPI 15569306
GO:0008227 G-protein coupled amine receptor activity IBA --
genes like me logo Genes that share ontologies with DRD1: view
genes like me logo Genes that share phenotypes with DRD1: view

Animal Models for DRD1 Gene

MGI Knock Outs for DRD1:

Animal Model Products

CRISPR Products

miRNA for DRD1 Gene

miRTarBase miRNAs that target DRD1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRD1

Clone Products

  • Addgene plasmids for DRD1
  • R&D Systems cDNA Clones for DRD1 (Dopamine D1 R/DRD1)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DRD1 Gene

Localization for DRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRD1 Gene COMPARTMENTS Subcellular localization image for DRD1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 2144334
genes like me logo Genes that share ontologies with DRD1: view

Pathways for DRD1 Gene

genes like me logo Genes that share pathways with DRD1: view

PCR Array Products

Interacting Proteins for DRD1 Gene

Selected Interacting proteins: P21728-DRD1_HUMAN for DRD1 Gene via I2D

Gene Ontology (GO) - Biological Process for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0001661 conditioned taste aversion IEA --
GO:0001662 behavioral fear response IEA --
GO:0001963 synaptic transmission, dopaminergic IBA --
GO:0001975 response to amphetamine IEA --
genes like me logo Genes that share ontologies with DRD1: view

Compounds for DRD1 Gene

(5) Tocris Compounds for DRD1 Gene

Compound Action Cas Number
Dihydrexidine hydrochloride Selective D1-like agonist [158704-02-0]
SCH 23390 hydrochloride Standard selective D1-like antagonist; also 5-HT2C agonist [125941-87-9]
SCH 39166 hydrobromide High affinity D1/D5 receptor antagonist [1227675-51-5]
SKF 38393 hydrobromide Selective D1-like agonist [20012-10-6]
SKF 81297 hydrobromide D1 agonist [67287-39-2]

(3) HMDB Compounds for DRD1 Gene

Compound Synonyms Cas Number PubMed IDs
Dopamine
  • 2-(3,4-Dihydroxyphenyl)ethylamine
62-31-7
Olanzapine
  • Lanzac
132539-06-1
Quetiapine
  • Quetiapine fumarate
111974-69-7

(47) Drugbank Compounds for DRD1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acepromazine
  • 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
61-00-7 target antagonist
Acetophenazine
2751-68-0 target antagonist
Amoxapine
14028-44-5 target antagonist
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist partial agonist

(30) IUPHAR Ligand for DRD1 Gene

Ligand Type Action Affinity Pubmed IDs
SCH-23390 Antagonist Antagonist 9.5
SKF-83556 Antagonist Antagonist 9.5
[3H]SCH-23390 Antagonist Antagonist 9.5
[125I]SCH23982 Antagonist Antagonist 9.5
(+)-butaclamol Antagonist Antagonist 8.5
cis flupentixol Antagonist Antagonist 8.4
ecopipam Antagonist Antagonist 8.3
SKF-82526 Agonist Full agonist 7.9
fluphenazine Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
(+)-SKF-82526 Agonist Full agonist 7.6
NPA Agonist Full agonist 7.4
lisuride Agonist Partial agonist 7.2
A68930 Agonist Agonist 6.82
SKF-38393 Agonist Full agonist 6.8
clozapine Antagonist Antagonist 6.7
spiperone Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
pergolide Agonist Full agonist 6.5
(+)-ADTN Agonist Full agonist 6.4
ketanserin Inhibitor Inhibition 6.3
bromocriptine Agonist Partial agonist 6.2
SKF-76783 Agonist Full agonist 6.2
haloperidol Antagonist Antagonist 6.1
rotigotine Agonist Full agonist 5.6
dopamine Agonist Full agonist 5.6
apomorphine Activator Activation 5.1
noradrenaline Agonist Full agonist 4.3
5-HT Inhibitor Inhibition 2.2
chlorpromazine Channel blocker None

(81) Novoseek inferred chemical compound relationships for DRD1 Gene

Compound -log(P) Hits PubMed IDs
dopamine 88.9 117
dihydrexidine 86.1 6
skf 81297 85.2 3
sch 23390 83.4 17
skf-83959 81 1

(1) PharmGKB related drug/compound annotations for DRD1 Gene

Drug/compound Annotation
lithium CA
genes like me logo Genes that share compounds with DRD1: view

Transcripts for DRD1 Gene

mRNA/cDNA for DRD1 Gene

(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD1 Gene

Dopamine receptor D1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRD1

Clone Products

  • Addgene plasmids for DRD1
  • R&D Systems cDNA Clones for DRD1 (Dopamine D1 R/DRD1)

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRD1 Gene

No ASD Table

Relevant External Links for DRD1 Gene

GeneLoc Exon Structure for
DRD1
ECgene alternative splicing isoforms for
DRD1

Expression for DRD1 Gene

mRNA expression in normal human tissues for DRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (14.4), Brain - Caudate (basal ganglia) (13.8), and Brain - Putamen (basal ganglia) (12.5).

SOURCE GeneReport for Unigene cluster for DRD1 Gene Hs.2624

mRNA Expression by UniProt/SwissProt for DRD1 Gene

P21728-DRD1_HUMAN
Tissue specificity: Detected in caudate, nucleus accumbens and in the olfactory tubercle.
genes like me logo Genes that share expressions with DRD1: view

In Situ Assay Products

No data available for Protein expression for DRD1 Gene

Orthologs for DRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD1 35
  • 99.85 (n)
  • 100 (a)
DRD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRD1 35
  • 91.03 (n)
  • 94.39 (a)
DRD1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRD1 35
  • 91.85 (n)
  • 95.52 (a)
DRD1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd1a 35
  • 87.1 (n)
  • 91.86 (a)
Drd1a 16
Drd1a 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRD1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drd1 35
  • 85.97 (n)
  • 90.95 (a)
chicken
(Gallus gallus)
Aves D1A 36
  • 75 (a)
OneToOne
DRD1 35
  • 77.48 (n)
  • 82.66 (a)
lizard
(Anolis carolinensis)
Reptilia DRD1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drd1 35
  • 72.22 (n)
  • 81.53 (a)
zebrafish
(Danio rerio)
Actinopterygii CT025914.2 36
  • 76 (a)
OneToMany
drd1b 35
  • 70.1 (n)
  • 75.18 (a)
drd1b 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta DopR 36
  • 28 (a)
OneToMany
CG6989 37
  • 34 (a)
CG6919 37
  • 39 (a)
DopR 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-1 36
  • 29 (a)
OneToMany
Species with no ortholog for DRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD1 Gene

ENSEMBL:
Gene Tree for DRD1 (if available)
TreeFam:
Gene Tree for DRD1 (if available)

Paralogs for DRD1 Gene

Paralogs for DRD1 Gene

genes like me logo Genes that share paralogs with DRD1: view

Variants for DRD1 Gene

Sequence variations from dbSNP and Humsavar for DRD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs686 -- 175,441,697(+) AGCAA(A/G)CCCCA utr-variant-3-prime
rs4532 -- 175,443,147(+) GTTCC(C/T)AAGCA utr-variant-5-prime
rs5326 -- 175,443,193(-) TGCCT(A/G)GTGGG utr-variant-5-prime
rs5327 - 175,442,990(-) TGTCC(A/C/G)SGCTC frameshift-variant, reference
rs5329 -- 175,442,959(-) GCTGC(A/C/G)GTTAT synonymous-codon, reference

Relevant External Links for DRD1 Gene

HapMap Linkage Disequilibrium report
DRD1
Human Gene Mutation Database (HGMD)
DRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DRD1 Gene

Disorders for DRD1 Gene

(33) Novoseek inferred disease relationships for DRD1 Gene

Disease -log(P) Hits PubMed IDs
calcyon 79.6 9
schizophrenia 59.3 33
parkinson disease 57.6 20
cerebral meningioma 56.5 5
attention-deficit hyperactivity disorder 51.4 2

Relevant External Links for DRD1

Genetic Association Database (GAD)
DRD1
Human Genome Epidemiology (HuGE) Navigator
DRD1
genes like me logo Genes that share disorders with DRD1: view

No data available for UniProtKB/Swiss-Prot for DRD1 Gene

Publications for DRD1 Gene

  1. Dopamine genes and pathological gambling in discordant sib-pairs. (PMID: 17394052) da Silva Lobo D.S. … Kennedy J.L. (J Gambl Stud 2007) 3 23 25 48
  2. Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. (PMID: 17455212) Dolzan V. … Breskvar K. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 25 48
  3. Molecular cloning and expression of the gene for a human D1 dopamine receptor. (PMID: 2144334) Dearry A. … Caron M.G. (Nature 1990) 3 4 23
  4. Cloning and expression of human and rat D1 dopamine receptors. (PMID: 2168520) Zhou Q.-Y. … Civelli O. (Nature 1990) 3 4 23
  5. Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. (PMID: 11723200) Holmes C. … Lovestone S. (J. Neurol. Neurosurg. Psychiatr. 2001) 3 23 48

Products for DRD1 Gene

  • Addgene plasmids for DRD1

Sources for DRD1 Gene

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