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DRD1 Gene

protein-coding   GIFtS: 67
GCID: GC05M174800

Dopamine Receptor D1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dopamine Receptor D11 2
Dopamine D1 Receptor2 3
DADR2
DRD1A2
D(1A) Dopamine Receptor2

External Ids:    HGNC: 30201   Entrez Gene: 18122   Ensembl: ENSG000001848457   OMIM: 1264495   UniProtKB: P217283   

Export aliases for DRD1 gene to outside databases

Previous GC identifers: GC05M175180 GC05M175606 GC05M174803 GC05M174848 GC05M169967


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DRD1 Gene:
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor
in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic
AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral
responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in
two transcript variants of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DRD1 Gene:
DRD1 (dopamine receptor D1) is a protein-coding gene. Diseases associated with DRD1 include cerebral meningioma, and transient cerebral ischemia. GO annotations related to this gene include dopamine binding and dopamine neurotransmitter receptor activity, coupled via Gs. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: DRD1_HUMAN, P21728
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

summary for DRD1 Gene:
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor
G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly
homologous and very few ligands have been identified that are selective between the D1 and D5 subtypes. D1
receptors are widely expressed throughout the brain, whereas D5 receptors show a restricted distribution
(mainly limbic areas).

Gene Wiki entry for DRD1 (Dopamine receptor D1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the DRD1 gene promoter:
         STAT5B   HFH-3   AML1a   FOXD1   HSF1 (long)   LCR-F1   FOXI1   Egr-2   HSF2   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRD1 promoter sequence
   Search Chromatin IP Primers for DRD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q34-q35

DRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRD1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M174800:  view genomic region     (about GC identifiers)

Start:
174,867,042 bp from pter      End:
174,871,211 bp from pter
Size:
4,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DRD1_HUMAN, P21728 (See protein sequence)
Recommended Name: D(1A) dopamine receptor  
Size: 446 amino acids; 49293 Da
Subunit: Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP
1 PDB 3D structure from and Proteopedia for DRD1:
1OZ5 (3D)    
Secondary accessions: B2RA44 Q4QRJ0

Explore the universe of human proteins at neXtProt for DRD1: NX_P21728

Explore proteomics data for DRD1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus

  • See DRD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000785.1  
    ENSEMBL proteins: 
     ENSP00000377353  
    Reactome Protein details: P21728

    DRD1 Human Recombinant Protein Products:

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    Novus Biologicals DRD1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DRD1

    DRD1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DRD1
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    Abcam antibodies for DRD1
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    LSBio Antibodies in human, mouse, rat for DRD1

    DRD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript DRD1-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for DRD1
    Cloud-Clone Corp. CLIAs for DRD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DRD: GPCR / Class A : Dopamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: D1 receptor
    Dopamine receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001413 Dopamine_D1_rcpt
     IPR000497 Dopamine_D5_rcpt
     IPR000929 Dopamine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21728

    ProtoNet protein and cluster: P21728

    2 Blocks protein domains:
    IPB000929 Dopamine receptor signature
    IPB001413 Dopamine 1A receptor signature


    UniProtKB/Swiss-Prot: DRD1_HUMAN, P21728
    Similarity: Belongs to the G-protein coupled receptor 1 family


    DRD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRD1_HUMAN, P21728
    Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase

         Genatlas biochemistry entry for DRD1:
    dopamine receptor D1,mainly expressed in hypophysis and parathyroid in ovary and granulosa luteal cells,adenylate
    cyclase stimulating,G protein coupled receptor superfamily,involved in the control of vascular tone

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs IMP1282671
    GO:0004930G-protein coupled receptor activity ----
    GO:0004952dopamine neurotransmitter receptor activity IDA1831904
    GO:0005515protein binding IPI15569306
    GO:0035240dopamine binding IMP1282671
         
    DRD1 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Drd1a) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  normal  respiratory system 

    DRD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DRD1: Drd1atm1Stl Drd1atm1Jcd Drd1atm1Tono

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DRD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRD1

    miRNA
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    miRTarBase miRNAs that target DRD1:
    hsa-mir-504-5p (MIRT000044)

    Block miRNA regulation of human, mouse, rat DRD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DRD1 (see all 36):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-502-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidDRD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DRD1
    Predesigned siRNA for gene silencing in human, mouse, rat DRD1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DRD1

    Clone
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    OriGene ORF clones in mouse, rat for DRD1
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    GenScript: all cDNA clones in your preferred vector: DRD1 (NM_000794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DRD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRD1_HUMAN, P21728: Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane;
    Multi-pass membrane protein (By similarity). Note=Transport from the endoplasmic reticulum to the cell surface is
    regulated by interaction with DNAJC14 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC2144334
    GO:0016020membrane ----

    DRD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DRD1 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Dopamine receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DRD1
        CDK5 Pathway
    Signaling in Gap Junctions
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    3 GeneGo (Thomson Reuters) Pathways for DRD1
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    3 BioSystems Pathways for DRD1
        Hypothetical Network for Drug Addiction
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for DRD1
        Dopamine receptors
    G alpha (s) signalling events

    1 PharmGKB Pathway for DRD1
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for DRD1) (see all 9):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Dopaminergic synapse
    Parkinson's disease


    DRD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DRD1: 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DRD1

    Selected Interacting proteins for DRD1 (P217283) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAP008133I2D: score=2 
    ADORA1P305423I2D: score=2 
    CALYQ9NYX43I2D: score=2 
    COPG1Q9Y6783I2D: score=2 
    COPG2Q9UBF23I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis IEA--
    GO:0001661conditioned taste aversion IEA--
    GO:0001662behavioral fear response IEA--
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0001975response to amphetamine IEA--

    DRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DRD1
      Browse compounds at ApexBio 

    Compounds for DRD1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 38393 hydrobromideSelective D1-like agonist[81633-77-4]
    SCH 39166 hydrobromideHigh affinity D1/D5 receptor antagonist--
    SKF 83959 hydrobromideD1-like partial agonist[80751-85-5]
    SKF 81297 hydrobromideD1 agonist[71636-61-8]
    SCH 23390 hydrochlorideStandard selective D1-like antagonist. Also 5-HT2C agonist[125941-87-9]

    3 HMDB Compounds for DRD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--

    Selected DrugBank Compounds for DRD1 (see all 47)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DopamineDopamin (see all 6)51-61-6targetagonist17455212 17301410 17468175 17394052 17449449
    MethylergonovineMethylergobasin (see all 7)113-42-8targetantagonist17139284 11752352 17016423 15930499 10200235
    ApomorphineApomorfin (see all 9)41372-20-7targetagonist11752352 12453049 10641988 18691132
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist11436517 10641988 18691132 16982285
    Dihydroergotoxine-- 11032-41-0targetantagonist agonist10084415 8786706 2869188 1606351
    Flupenthixol-- 2709-56-0targetantagonist10531405 17139284 17016423 17111172
    FluphenazineFluorfenazine (see all 6)69-23-8targetantagonist11113312 10531405 11752352 11873706
    CarphenazineCarfenazine (see all 2)2622-30-2targetantagonist4861216 4887393 4889058
    ChlorprothixeneAlpha-Chlorprothixene (see all 9)113-59-7targetantagonist17139284 17016423 1830565
    FenoldopamFenodopam mesylate (see all 3)67227-57-0targetagonist19293728 8103596 11752352

    Selected IUPHAR Ligands for DRD1 (D1 receptor) (see all 30)    About this table
    LigandTypeActionAffinityPubmed IDs
    SCH-23390
    AntagonistAntagonist7.4 - 9.57525564 1826762
    SKF-83556
    AntagonistAntagonist9.51826762
    [3H]SCH-23390
    AntagonistAntagonist9.52168520
    [125I]SCH23982
    AntagonistAntagonist9.52144334
    (+)-butaclamol
    AntagonistAntagonist6.5 - 8.57525564 1826762
    cis flupentixol
    AntagonistAntagonist7 - 8.47525564 1826762
    ecopipam
    AntagonistAntagonist8.37862709
    SKF-82526
    AgonistFull agonist6.5 - 7.97525564
    fluphenazine
    AntagonistAntagonist7.71826762
    (+)-SKF-82526
    AgonistFull agonist5.7 - 7.61826762

    Selected Novoseek inferred chemical compound relationships for DRD1 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopamine 88.9 211 12738794 (3), 8105856 (2), 9881592 (2), 1826481 (2) (see all 99)
    dihydrexidine 86.1 7 7914538 (2), 8100195 (2), 8786574 (1), 7566481 (1)
    skf 81297 85.2 4 9336323 (1), 14592686 (1), 14757130 (1)
    sch 23390 83.4 19 11465634 (2), 17562373 (1), 1356432 (1), 8505636 (1) (see all 16)
    skf-83959 81 1 16771826 (1)
    skf 38393 80.8 11 9730903 (2), 10837822 (2), 15255946 (1), 18381284 (1) (see all 8)
    quinpirole 72.5 6 16549074 (1), 1977110 (1), 12429201 (1), 7895776 (1) (see all 5)
    skf-82958 69.2 2 14757130 (1), 7566481 (1)
    sulpiride 68.9 6 14757137 (1), 1695244 (1), 1675997 (1), 7895776 (1) (see all 5)
    (+)-butaclamol 66.7 2 1385626 (1)

    1 PharmGKB related drug/compound annotation for DRD1 gene    About this table
    Drug/compound PharmGKB Annotation
    lithiumCA  



    DRD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DRD1 gene: 
    NM_000794.3  

    Unigene Cluster for DRD1:

    Dopamine receptor D1
    Hs.2624  [show with all ESTs]
    Unigene Representative Sequence: NM_000794
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000393752(uc003mcz.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DRD1 (see all 36):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-502-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidDRD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DRD1
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    GenScript: all cDNA clones in your preferred vector: DRD1 (NM_000794)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRD1
    Primer
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    OriGene qPCR primer pairs and template standards for DRD1
    OriGene qSTAR qPCR primer pairs in human, mouse for DRD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRD1
      QuantiTect SYBR Green Assays in human, mouse, rat DRD1
      QuantiFast Probe-based Assays in human, mouse, rat DRD1

    Additional mRNA sequence: 

    AF498961.1 AK314031.1 BC074978.2 BC074979.2 BC096837.1 CR541922.1 X58987.1 

    1 DOTS entry:

    DT.308039 

    13 AceView cDNA sequences:

    AF498961 BM690062 CB565882 BC074979 CK903140 X58987 CR541922 NM_000794 
    BC074978 CA950381 BV183492 BV183491 BM661781 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCAGGTAG
    DRD1 Expression
    About this image


    DRD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    DRD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2624

    UniProtKB/Swiss-Prot: DRD1_HUMAN, P21728
    Tissue specificity: Detected in caudate, nucleus accumbens and in the olfactory tubercle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DRD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Drd1a1 , 5 dopamine receptor D1A1, 5 87.1(n)1
    91.86(a)1
      13 (28.40 cM)5
    134881  NM_010076.31  NP_034206.11 
     540511865 
    chicken
    (Gallus gallus)
    Aves DRD11 dopamine receptor D1 77.48(n)
    82.66(a)
      427633  NM_001144848.1  NP_001138320.1 
    lizard
    (Anolis carolinensis)
    Reptilia DRD16
    dopamine receptor D1
    81(a)
    1 ↔ 1
    2(137143913-137145274)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia drd11 dopamine receptor D1 72.22(n)
    81.53(a)
      100485463  XM_004912869.1  XP_004912926.1 
    zebrafish
    (Danio rerio)
    Actinopterygii drd1b1 dopamine receptor D1b 70.1(n)
    75.18(a)
      568126  NM_001135976.2  NP_001129448.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR3 dopamine receptor signaling pathway
    G-protein more
    39(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea dop-16
    Protein DOP-1, isoform a
    29(a)
    1 → many
    X(4411380-4416079) WBGene00001052


    ENSEMBL Gene Tree for DRD1 (if available)
    TreeFam Gene Tree for DRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRD1 gene
    TAAR62  HTR62  TAAR22  ADRB12  TAAR92  TAAR82  HRH22  TAAR12  
    ADRB22  HTR42  ADRB32  DRD52  TAAR52  
    Selected SIMAP similar genes for DRD1 using alignment to 2 protein entries:     DRD1_HUMAN (see all proteins) (see all similar genes):
    DRD5P1    DRD5P2    DRD5    ADRB2    HRH3    DRD2
    HTR1D    HTR5A    ADRA1A    ADRA1B    ADRA1D    HRH2
    HTR4    HTR1B    ADRB1    TAAR9    HTR7    HTR4B

    DRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DRD1 (see all 150)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446671961,2
    C--175094770(+) TATCAA/GGAAGA 1 -- ds50010--------
    rs1398415231,2
    --175094777(+) AAGAAC/TACGTT 1 -- ds50010--------
    rs1410036851,2
    C--175094819(+) CCCCA-/CGAGTT 1 -- ds50010--------
    rs1142913381,2
    C,F--175094864(+) CAGTCC/TGGGTG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1439241061,2
    --175094885(+) AACCTA/GATTCC 1 -- ds50010--------
    rs1165554191,2
    C,F--175095314(+) GCAGCA/GTATAC 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs1472618781,2
    --175095435(+) TAAAAC/TGTTTT 1 -- ut310--------
    rs48677981,2
    C,F,A,H--175095464(+) ACTTTT/CTTAAA 1 -- ut3120Minor allele frequency- C:0.36NS EA NA CSA WA 2685
    rs1488690031,2
    C--175095636(+) CTCAC-/AGAGTCT 1 -- ut310--------
    rs623883191,2
    C,F--175095695(+) ATGTGG/ATTGTA 1 -- ut312Minor allele frequency- A:0.03NA 122

    HapMap Linkage Disequilibrium report for DRD1 (174867042 - 174871211 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DRD1: --
    Human Gene Mutation Database (HGMD): DRD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DRD1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 126449    OMIM disorders: --

    Selected diseases for DRD1 (see all 54):    
    About MalaCards
    cerebral meningioma    transient cerebral ischemia    early-onset schizophrenia    pathological gambling
    drug addiction    migraine without aura    neuroepithelioma    narcolepsy
    striatonigral degeneration    restless legs syndrome    tardive dyskinesia    attention deficit hyperactivity disorder
    obsessive-compulsive disorder    cholera    cocaine dependence    alcohol dependence
    bipolar i disorder    bipolar disorder    meningioma    brain disease

    4 diseases from the University of Copenhagen DISEASES database for DRD1:
    Schizophrenia     Pathological gambling     Attention deficit hyperactivity disorder     Alcohol dependence

    DRD1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for DRD1 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 79.6 10 11567648 (6), 14534309 (1), 12853145 (1), 10698743 (1)
    schizophrenia 59.3 36 9024661 (2), 20127886 (2), 17455212 (2), 8837716 (2) (see all 27)
    parkinson disease 57.6 20 16840977 (2), 8505636 (2), 10401786 (2), 8558425 (1) (see all 17)
    cerebral meningioma 56.5 5 1385626 (4), 8869066 (1)
    attention-deficit hyperactivity disorder 51.4 2 9613858 (1), 14569274 (1)
    neuroepithelioma 40.9 1 16595738 (1)
    bipolar disorder 38.3 20 12488059 (4), 16397404 (3), 1385598 (2), 8837716 (2) (see all 10)
    catalepsy 36.8 2 1975782 (1), 2154287 (1)
    drug addiction 36.5 1 19179847 (1)
    huntington disease 36.1 2 8172940 (2)

    Genetic Association Database (GAD): DRD1
    Human Genome Epidemiology (HuGE) Navigator: DRD1 (93 documents)

    Export disorders for DRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRD1 gene, integrated from 10 sources (see all 624):
    (articles sorted by number of sources associating them with DRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. (PubMed id 17455212)1, 4, 7, 9 Dolzan V....Breskvar K. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    2. Dopamine genes and pathological gambling in discordant sib-pairs. (PubMed id 17394052)1, 4, 7, 9 da Silva Lobo D.S....Kennedy J.L. (J Gambl Stud 2007)
    3. A haplotype of the DRD1 gene is associated with alcohol dependence. (PubMed id 18341651)1, 4, 9 Batel P....Gorwood P. (Alcohol. Clin. Exp. Res. 2008)
    4. Association of the dopamine receptor D1 gene, DRD1, with inattention symptoms in families selected for reading problems. (PubMed id 17310237)1, 4, 9 Luca P....Barr C.L. (Mol. Psychiatry 2007)
    5. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. (PubMed id 18413491)1, 4, 9 Staessen J.A....Brand E. (Hypertension 2008)
    6. A DRD1 haplotype is associated with risk for autism spectrum disorders in male-only affected sib-pair families. (PubMed id 18205172)1, 4, 9 Hettinger J.A....Holden J.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    7. Association analysis between Tourette's syndrome and dopamine D1 receptor gene in Taiwanese children. (PubMed id 15564897)1, 4, 9 Chou I.C....Tsai F.J. (Psychiatr. Genet. 2004)
    8. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. (PubMed id 19675531)1, 4, 9 Fung M.M....O'Connor D.T. (Kidney Int. 2009)
    9. 5' UTR polymorphism of dopamine receptor D1 (DRD1) associated with severity and temperament of alcoholism. (PubMed id 17466946)1, 4, 9 Kim D.J....Shin H.D. (Biochem. Biophys. Res. Commun. 2007)
    10. Molecular cloning and expression of the gene for a human D1 dopamine receptor. (PubMed id 2144334)1, 2, 9 Dearry A....Caron M.G. (Nature 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1812 HGNC: 3020 AceView: DRD1 Ensembl:ENSG00000184845 euGenes: HUgn1812
    ECgene: DRD1 Kegg: 1812 H-InvDB: DRD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DRD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRD1 gene:
    Search GeneIP for patents involving DRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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