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Aliases for DRC3 Gene

Aliases for DRC3 Gene

  • Dynein Regulatory Complex Subunit 3 2 3 5
  • Leucine-Rich Repeat-Containing Protein 48 3 4
  • Leucine Rich Repeat Containing 48 2 3
  • LRRC48 3 4
  • CFAP134 3

External Ids for DRC3 Gene

Previous HGNC Symbols for DRC3 Gene

  • LRRC48

Summaries for DRC3 Gene

GeneCards Summary for DRC3 Gene

DRC3 (Dynein Regulatory Complex Subunit 3) is a Protein Coding gene. An important paralog of this gene is LRRC9.

UniProtKB/Swiss-Prot for DRC3 Gene

  • Key component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary motility.

Gene Wiki entry for DRC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRC3 Gene

Genomics for DRC3 Gene

Regulatory Elements for DRC3 Gene

Enhancers for DRC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DRC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DRC3 Gene

17,972,780 bp from pter
18,016,889 bp from pter
44,110 bases
Plus strand

Genomic View for DRC3 Gene

Genes around DRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRC3 Gene

Proteins for DRC3 Gene

  • Protein details for DRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynein regulatory complex subunit 3
    Protein Accession:
    Secondary Accessions:
    • A8KAE6
    • Q86SF9
    • Q86W73
    • Q8IWG0

    Protein attributes for DRC3 Gene

    523 amino acids
    Molecular mass:
    61054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DRC3 Gene


neXtProt entry for DRC3 Gene

Post-translational modifications for DRC3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DRC3 Gene

Domains & Families for DRC3 Gene

Gene Families for DRC3 Gene

Protein Domains for DRC3 Gene

Suggested Antigen Peptide Sequences for DRC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRCT domain.
  • Belongs to the DRC3 family.
  • Contains 5 LRR (leucine-rich) repeats.
  • Contains 1 LRRCT domain.
  • Belongs to the DRC3 family.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with DRC3: view

Function for DRC3 Gene

Molecular function for DRC3 Gene

UniProtKB/Swiss-Prot Function:
Key component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary motility.

Phenotypes for DRC3 Gene

GenomeRNAi human phenotypes for DRC3:
genes like me logo Genes that share phenotypes with DRC3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DRC3 Gene

Localization for DRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRC3 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Gene Ontology (GO) - Cellular Components for DRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with DRC3: view

No data available for Subcellular locations from COMPARTMENTS for DRC3 Gene

Pathways & Interactions for DRC3 Gene

SuperPathways for DRC3 Gene

No Data Available

Interacting Proteins for DRC3 Gene

Gene Ontology (GO) - Biological Process for DRC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for DRC3 Gene

Drugs & Compounds for DRC3 Gene

No Compound Related Data Available

Transcripts for DRC3 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRC3 Gene

No ASD Table

Relevant External Links for DRC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of DRC3 Gene:

genes like me logo Genes that share expression patterns with DRC3: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DRC3 Gene

Orthologs for DRC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DRC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC48 34
  • 85.92 (n)
  • 85.85 (a)
LRRC48 35
  • 85 (a)
(Canis familiaris)
Mammalia LRRC48 34
  • 85.79 (n)
  • 82.22 (a)
LRRC48 35
  • 82 (a)
(Mus musculus)
Mammalia Lrrc48 34
  • 83.43 (n)
  • 80.88 (a)
Lrrc48 16
Lrrc48 35
  • 81 (a)
(Pan troglodytes)
Mammalia LRRC48 34
  • 99.04 (n)
  • 98.09 (a)
LRRC48 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Lrrc48 34
  • 82.92 (n)
  • 80.5 (a)
(Monodelphis domestica)
Mammalia LRRC48 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC48 35
  • 67 (a)
(Gallus gallus)
Aves LRRC48 34
  • 62.94 (n)
  • 56.07 (a)
LRRC48 35
  • 55 (a)
(Anolis carolinensis)
Reptilia LRRC48 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc48 34
  • 64.41 (n)
  • 58.99 (a)
(Danio rerio)
Actinopterygii lrrc48 34
  • 59.21 (n)
  • 50.7 (a)
lrrc48 35
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010129 34
  • 45.69 (n)
  • 35.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ppr-Y 34
  • 46 (n)
  • 36.8 (a)
Ppr-Y 35
  • 30 (a)
TbCMF46 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDS22 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
Species where no ortholog for DRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DRC3 Gene

Gene Tree for DRC3 (if available)
Gene Tree for DRC3 (if available)

Paralogs for DRC3 Gene

Paralogs for DRC3 Gene

genes like me logo Genes that share paralogs with DRC3: view

Variants for DRC3 Gene

Sequence variations from dbSNP and Humsavar for DRC3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_025625 -
VAR_051120 -
VAR_051121 -
rs4299203 -- 17,974,845(+) CTGGG(G/T)TAAAG intron-variant
rs4321247 -- 17,975,298(+) CCTCC(A/G)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRC3 Gene

Variant ID Type Subtype PubMed ID
esv2668379 CNV deletion 23128226
esv3640139 CNV loss 21293372
nsv1132448 CNV duplication 24896259
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241
nsv510701 CNV deletion 20534489
nsv960428 CNV duplication 23825009

Variation tolerance for DRC3 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRC3 Gene

Disorders for DRC3 Gene

Relevant External Links for DRC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRC3 Gene

Publications for DRC3 Gene

  1. The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans. (PMID: 23354437) Wirschell M. … Omran H. (Nat. Genet. 2013) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W. … Lupski J.R. (Genome Res. 2002) 2 3 65
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 65

Products for DRC3 Gene

Sources for DRC3 Gene

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