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Aliases for DRC1 Gene

Aliases for DRC1 Gene

  • Dynein Regulatory Complex Subunit 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 164 3 4
  • C2orf39 3 4
  • CCDC164 3 4
  • Dynein Regulatory Complex Subunit 1 Homolog (Chlamydomonas) 2
  • Chromosome 2 Open Reading Frame 39 2
  • Coiled-Coil Domain Containing 164 2
  • CILD21 3

External Ids for DRC1 Gene

Previous HGNC Symbols for DRC1 Gene

  • C2orf39
  • CCDC164

Previous GeneCards Identifiers for DRC1 Gene

  • GC02P026626

Summaries for DRC1 Gene

Entrez Gene Summary for DRC1 Gene

  • This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015]

GeneCards Summary for DRC1 Gene

DRC1 (Dynein Regulatory Complex Subunit 1) is a Protein Coding gene. Diseases associated with DRC1 include Ciliary Dyskinesia, Primary, 21 and Primary Ciliary Dyskinesia21: Drc1-Related Primary Ciliary Dyskinesia.

UniProtKB/Swiss-Prot for DRC1 Gene

  • Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRC1 Gene

Genomics for DRC1 Gene

Regulatory Elements for DRC1 Gene

Enhancers for DRC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DRC1 on UCSC Golden Path with GeneCards custom track

Promoters for DRC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DRC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DRC1 Gene

26,401,916 bp from pter
26,456,713 bp from pter
54,798 bases
Plus strand

Genomic View for DRC1 Gene

Genes around DRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRC1 Gene

Proteins for DRC1 Gene

  • Protein details for DRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynein regulatory complex protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K1N8
    • Q53R91
    • Q53TA3
    • Q8NDI5

    Protein attributes for DRC1 Gene

    740 amino acids
    Molecular mass:
    87134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DRC1 Gene

Proteomics data for DRC1 Gene at MOPED

Post-translational modifications for DRC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRC1 Gene

Domains & Families for DRC1 Gene

Gene Families for DRC1 Gene

Protein Domains for DRC1 Gene


Suggested Antigen Peptide Sequences for DRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DRC1 family.
  • Belongs to the DRC1 family.
genes like me logo Genes that share domains with DRC1: view

Function for DRC1 Gene

Molecular function for DRC1 Gene

UniProtKB/Swiss-Prot Function:
Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending.
genes like me logo Genes that share phenotypes with DRC1: view

Human Phenotype Ontology for DRC1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DRC1 Gene

Localization for DRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRC1 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DRC1 Gene

Pathways & Interactions for DRC1 Gene

SuperPathways for DRC1 Gene

No Data Available

Interacting Proteins for DRC1 Gene

Gene Ontology (GO) - Biological Process for DRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007507 heart development IEA --
GO:0060285 cilium-dependent cell motility IMP 23354437
GO:0070286 axonemal dynein complex assembly IMP 23354437
genes like me logo Genes that share ontologies with DRC1: view

No data available for Pathways by source and SIGNOR curated interactions for DRC1 Gene

Drugs & Compounds for DRC1 Gene

No Compound Related Data Available

Transcripts for DRC1 Gene

Unigene Clusters for DRC1 Gene

Dynein regulatory complex subunit 1 homolog (Chlamydomonas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - -
SP2: - -
SP3: - - -

Relevant External Links for DRC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRC1 Gene

mRNA expression in normal human tissues for DRC1 Gene

mRNA differential expression in normal tissues according to GTEx for DRC1 Gene

This gene is overexpressed in Testis (x17.8) and Brain - Hypothalamus (x4.9).

Protein differential expression in normal tissues from HIPED for DRC1 Gene

This gene is overexpressed in Adipocyte (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DRC1 Gene

SOURCE GeneReport for Unigene cluster for DRC1 Gene Hs.393714

genes like me logo Genes that share expression patterns with DRC1: view

Protein tissue co-expression partners for DRC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DRC1 Gene

Orthologs for DRC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DRC1 35
  • 85.02 (n)
  • 85.11 (a)
DRC1 36
  • 85 (a)
(Canis familiaris)
Mammalia CCDC164 35
  • 86.29 (n)
  • 85.87 (a)
DRC1 36
  • 86 (a)
(Mus musculus)
Mammalia Drc1 35
  • 79.21 (n)
  • 76.32 (a)
Drc1 16
Drc1 36
  • 74 (a)
(Pan troglodytes)
Mammalia CCDC164 35
  • 99.5 (n)
  • 99.05 (a)
CCDC164 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Drc1 35
  • 79.09 (n)
  • 77.51 (a)
(Monodelphis domestica)
Mammalia DRC1 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves CCDC164 35
  • 63.47 (n)
  • 57.22 (a)
DRC1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia DRC1 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia drc1 35
  • 62.1 (n)
  • 56.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68877 35
(Danio rerio)
Actinopterygii drc1 35
  • 59.23 (n)
  • 49.08 (a)
drc1 36
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9642 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002143 35
  • 42.53 (n)
  • 28.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10958 35
  • 44.64 (n)
  • 29.57 (a)
CG10958 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for DRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DRC1 Gene

Gene Tree for DRC1 (if available)
Gene Tree for DRC1 (if available)

Paralogs for DRC1 Gene

No data available for Paralogs for DRC1 Gene

Variants for DRC1 Gene

Sequence variations from dbSNP and Humsavar for DRC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3795958 - 26,444,262(+) ATGCC(A/G)AGCAA reference, missense
rs939820 - 26,444,747(-) CTCCC(A/G)AAACT reference, missense
rs12623642 - 26,453,527(+) CCTTC(A/G/T)TCATG reference, missense
rs3172008 - 26,455,172(+) AAACA(G/T)TTCTC reference, missense
rs35313480 - 26,456,494(+) CTCAG(A/G)TGTTG reference, missense

Variation tolerance for DRC1 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.63; 95.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRC1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DRC1 Gene

Disorders for DRC1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for DRC1 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ciliary dyskinesia, primary, 21
  • cild21
primary ciliary dyskinesia21: drc1-related primary ciliary dyskinesia
  • ciliary dyskinesia, primary, 21
ciliary dyskinesia, primary, 1, with or without situs inversus
  • kartagener syndrome
kartagener syndrome
  • kartagener's syndrome
  • kartagener syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DRC1 in MalaCards View complete list of genes associated with diseases


  • Ciliary dyskinesia, primary, 21 (CILD21) [MIM:615294]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. {ECO:0000269 PubMed:23354437, ECO:0000269 PubMed:25186273}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DRC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DRC1: view

No data available for Genatlas for DRC1 Gene

Publications for DRC1 Gene

  1. The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans. (PMID: 23354437) Wirschell M. … Omran H. (Nat. Genet. 2013) 2 3 4 67
  2. Detailed structural and biochemical characterization of the nexin-dynein regulatory complex. (PMID: 25411337) Oda T. … Kikkawa M. (Mol. Biol. Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia. (PMID: 25186273) Raidt J. … Werner C. (Eur. Respir. J. 2014) 3

Products for DRC1 Gene

Sources for DRC1 Gene