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Aliases for DRC1 Gene

Aliases for DRC1 Gene

  • Dynein Regulatory Complex Subunit 1 2 3
  • C2orf39 3 4 6
  • CCDC164 3 4 6
  • Coiled-Coil Domain-Containing Protein 164 3 4
  • Coiled-Coil Domain Containing 164 2 3
  • CILD21 3 6
  • Dynein Regulatory Complex Subunit 1 Homolog (Chlamydomonas) 2
  • Dynein Regulatory Complex Subunit 1 Homolog 3
  • Dynein Regulatory Complex Protein 1 3
  • Chromosome 2 Open Reading Frame 39 2

External Ids for DRC1 Gene

Previous HGNC Symbols for DRC1 Gene

  • C2orf39
  • CCDC164

Previous GeneCards Identifiers for DRC1 Gene

  • GC02P026626

Summaries for DRC1 Gene

GeneCards Summary for DRC1 Gene

DRC1 (Dynein Regulatory Complex Subunit 1) is a Protein Coding gene. Diseases associated with DRC1 include ciliary dyskinesia, primary, 21.

UniProtKB/Swiss-Prot for DRC1 Gene

  • Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRC1 Gene

Genomics for DRC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DRC1 Gene

Start:
26,401,916 bp from pter
End:
26,456,711 bp from pter
Size:
54,796 bases
Orientation:
Plus strand

Genomic View for DRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRC1 Gene

No data available for Regulatory Elements for DRC1 Gene

Proteins for DRC1 Gene

  • Protein details for DRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MC2-DRC1_HUMAN
    Recommended name:
    Dynein regulatory complex protein 1
    Protein Accession:
    Q96MC2
    Secondary Accessions:
    • A8K1N8
    • Q53R91
    • Q53TA3
    • Q8NDI5

    Protein attributes for DRC1 Gene

    Size:
    740 amino acids
    Molecular mass:
    87134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DRC1 Gene

Proteomics data for DRC1 Gene at MOPED

Post-translational modifications for DRC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRC1 Gene

Domains for DRC1 Gene

Protein Domains for DRC1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96MC2

UniProtKB/Swiss-Prot:

DRC1_HUMAN :
  • Q96MC2
Family:
  • Belongs to the DRC1 family.
genes like me logo Genes that share domains with DRC1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for DRC1 Gene

Function for DRC1 Gene

Molecular function for DRC1 Gene

UniProtKB/Swiss-Prot Function: Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending.

Phenotypes for DRC1 Gene

genes like me logo Genes that share phenotypes with DRC1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DRC1 Gene

Localization for DRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRC1 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Gene Ontology (GO) - Cellular Components for DRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0005930 axoneme ISS --
genes like me logo Genes that share ontologies with DRC1: view

No data available for Subcellular locations from COMPARTMENTS for DRC1 Gene

Pathways for DRC1 Gene

SuperPathways for DRC1 Gene

No Data Available

Interacting Proteins for DRC1 Gene

Gene Ontology (GO) - Biological Process for DRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060285 cilium-dependent cell motility IMP 23354437
GO:0070286 axonemal dynein complex assembly IMP 23354437
GO:0071973 bacterial-type flagellum-dependent cell motility IMP 23354437
genes like me logo Genes that share ontologies with DRC1: view

No data available for Pathways by source for DRC1 Gene

Transcripts for DRC1 Gene

Unigene Clusters for DRC1 Gene

Dynein regulatory complex subunit 1 homolog (Chlamydomonas):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DRC1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for DRC1 Gene

GeneLoc Exon Structure for
DRC1
ECgene alternative splicing isoforms for
DRC1

Expression for DRC1 Gene

mRNA expression in normal human tissues for DRC1 Gene

mRNA differential expression in normal tissues according to GTEx for DRC1 Gene

This gene is overexpressed in Testis (17.8) and Brain - Hypothalamus (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DRC1 Gene

SOURCE GeneReport for Unigene cluster for DRC1 Gene Hs.393714

genes like me logo Genes that share expressions with DRC1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DRC1 Gene

Orthologs for DRC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC164 35
  • 99.5 (n)
  • 99.05 (a)
CCDC164 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRC1 35
  • 85.02 (n)
  • 85.11 (a)
DRC1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC164 35
  • 86.29 (n)
  • 85.87 (a)
DRC1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc164 16
Drc1 35
  • 79.21 (n)
  • 76.32 (a)
Drc1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRC1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Drc1 35
  • 79.09 (n)
  • 77.51 (a)
chicken
(Gallus gallus)
Aves CCDC164 35
  • 63.47 (n)
  • 57.22 (a)
DRC1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRC1 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68877 35
tropical clawed frog
(Silurana tropicalis)
Amphibia drc1 35
  • 62.1 (n)
  • 56.34 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9642 35
zebrafish
(Danio rerio)
Actinopterygii drc1 35
  • 59.23 (n)
  • 49.08 (a)
drc1 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002143 35
  • 42.53 (n)
  • 28.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10958 35
  • 44.64 (n)
  • 29.57 (a)
CG10958 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for DRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DRC1 Gene

ENSEMBL:
Gene Tree for DRC1 (if available)
TreeFam:
Gene Tree for DRC1 (if available)

Paralogs for DRC1 Gene

No data available for Paralogs for DRC1 Gene

Variants for DRC1 Gene

Sequence variations from dbSNP and Humsavar for DRC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs939820 - 26,444,747(-) CTCCC(A/G)AAACT missense, reference
rs1054737 -- 26,456,526(+) GGACC(A/G)CCAAA utr-variant-3-prime
rs1344734 -- 26,414,200(-) CAGGA(A/G)TTCAA intron-variant
rs1402962 -- 26,453,454(+) AAGGA(A/G)GAAGA synonymous-codon, reference
rs1464489 -- 26,443,819(-) GCAAG(A/G)AAATT intron-variant

Relevant External Links for DRC1 Gene

HapMap Linkage Disequilibrium report
DRC1
Human Gene Mutation Database (HGMD)
DRC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DRC1 Gene

Disorders for DRC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DRC1 Gene including...

Search for DRC1 Gene in MalaCards »

(1) OMIM Diseases for DRC1 Gene (615288)

UniProtKB/Swiss-Prot

DRC1_HUMAN
  • Ciliary dyskinesia, primary, 21 (CILD21) [MIM:615294]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. {ECO:0000269 PubMed:23354437, ECO:0000269 PubMed:25186273}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with DRC1: view

Publications for DRC1 Gene

  1. The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans. (PMID: 23354437) Wirschell M. … Omran H. (Nat. Genet. 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx J.J. … Ophoff R.A. (Mol. Psychiatry 2013) 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for DRC1 Gene

Sources for DRC1 Gene

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