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Aliases for DRAXIN Gene

Aliases for DRAXIN Gene

  • Dorsal Inhibitory Axon Guidance Protein 2 3 4
  • Dorsal Repulsive Axon Guidance Protein 2 3 4
  • Neural Tissue-Specific Cysteine-Rich Protein 2 3
  • C1orf187 3 4
  • Neucrin 3 4
  • Chromosome 1 Open Reading Frame 187 2
  • AGPA3119 3
  • UNQ3119 3

External Ids for DRAXIN Gene

Previous HGNC Symbols for DRAXIN Gene

  • C1orf187

Previous GeneCards Identifiers for DRAXIN Gene

  • GC01P011753

Summaries for DRAXIN Gene

GeneCards Summary for DRAXIN Gene

DRAXIN (Dorsal Inhibitory Axon Guidance Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DRAXIN Gene

  • Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAXIN Gene

Genomics for DRAXIN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DRAXIN Gene

Chromosome:
1
Start:
11,686,647 bp from pter
End:
11,725,857 bp from pter
Size:
39,211 bases
Orientation:
Plus strand

Genomic View for DRAXIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DRAXIN Gene

No data available for Regulatory Elements for DRAXIN Gene

Proteins for DRAXIN Gene

  • Protein details for DRAXIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI3-DRAXI_HUMAN
    Recommended name:
    Draxin
    Protein Accession:
    Q8NBI3
    Secondary Accessions:
    • B6EV15
    • Q5SNX0
    • Q6UWK8

    Protein attributes for DRAXIN Gene

    Size:
    349 amino acids
    Molecular mass:
    38650 Da
    Quaternary structure:
    • Interacts with LRP6.

neXtProt entry for DRAXIN Gene

Proteomics data for DRAXIN Gene at MOPED

Post-translational modifications for DRAXIN Gene

  • Glycosylation at Thr 84 and Asn 264
  • Modification sites at PhosphoSitePlus

Other Protein References for DRAXIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRAXIN Gene

Domains & Families for DRAXIN Gene

Protein Domains for DRAXIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRAXIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBI3

UniProtKB/Swiss-Prot:

DRAXI_HUMAN :
  • Belongs to the draxin family.
Family:
  • Belongs to the draxin family.
genes like me logo Genes that share domains with DRAXIN: view

No data available for Gene Families for DRAXIN Gene

Function for DRAXIN Gene

Molecular function for DRAXIN Gene

UniProtKB/Swiss-Prot Function:
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

Gene Ontology (GO) - Molecular Function for DRAXIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26190107
genes like me logo Genes that share ontologies with DRAXIN: view

Phenotypes for DRAXIN Gene

MGI mutant phenotypes for DRAXIN:
inferred from 1 alleles
GenomeRNAi human phenotypes for DRAXIN:
genes like me logo Genes that share phenotypes with DRAXIN: view

Animal Model Products

CRISPR Products

miRNA for DRAXIN Gene

miRTarBase miRNAs that target DRAXIN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRAXIN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DRAXIN Gene

Localization for DRAXIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAXIN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRAXIN Gene COMPARTMENTS Subcellular localization image for DRAXIN gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for DRAXIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
genes like me logo Genes that share ontologies with DRAXIN: view

Pathways & Interactions for DRAXIN Gene

SuperPathways for DRAXIN Gene

No Data Available

Interacting Proteins for DRAXIN Gene

Selected Interacting proteins: Q8NBI3-DRAXI_HUMAN for DRAXIN Gene via UniProtKB

Gene Ontology (GO) - Biological Process for DRAXIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0021516 dorsal spinal cord development ISS --
GO:0021528 commissural neuron differentiation in spinal cord ISS --
GO:0030517 negative regulation of axon extension IEA --
genes like me logo Genes that share ontologies with DRAXIN: view

No data available for Pathways by source and SIGNOR curated interactions for DRAXIN Gene

Drugs & Compounds for DRAXIN Gene

No Compound Related Data Available

Transcripts for DRAXIN Gene

mRNA/cDNA for DRAXIN Gene

Unigene Clusters for DRAXIN Gene

Dorsal inhibitory axon guidance protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRAXIN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRAXIN Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for DRAXIN Gene

GeneLoc Exon Structure for
DRAXIN
ECgene alternative splicing isoforms for
DRAXIN

Expression for DRAXIN Gene

mRNA expression in normal human tissues for DRAXIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRAXIN Gene

This gene is overexpressed in Whole Blood (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Cerebellum (x4.5), Brain - Amygdala (x4.4), and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for DRAXIN Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DRAXIN Gene



SOURCE GeneReport for Unigene cluster for DRAXIN Gene Hs.632364

genes like me logo Genes that share expression patterns with DRAXIN: view

Protein tissue co-expression partners for DRAXIN Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DRAXIN Gene

Orthologs for DRAXIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DRAXIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C16H1orf187 35
  • 86.73 (n)
  • 86.21 (a)
DRAXIN 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRAXIN 35
  • 85.63 (n)
  • 81.74 (a)
DRAXIN 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Draxin 35
  • 80.7 (n)
  • 78.36 (a)
Draxin 16
Draxin 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DRAXIN 35
  • 99.62 (n)
  • 99.43 (a)
DRAXIN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Draxin 35
  • 79.86 (n)
  • 78.59 (a)
oppossum
(Monodelphis domestica)
Mammalia DRAXIN 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRAXIN 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C21H1ORF187 35
  • 65.31 (n)
  • 60.82 (a)
DRAXIN 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia draxin 35
  • 56 (n)
  • 51.47 (a)
zebrafish
(Danio rerio)
Actinopterygii draxin 36
  • 38 (a)
OneToMany
DRAXIN (2 of 2) 36
  • 33 (a)
OneToMany
Species with no ortholog for DRAXIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DRAXIN Gene

ENSEMBL:
Gene Tree for DRAXIN (if available)
TreeFam:
Gene Tree for DRAXIN (if available)

Paralogs for DRAXIN Gene

Pseudogenes.org Pseudogenes for DRAXIN Gene

genes like me logo Genes that share paralogs with DRAXIN: view

No data available for Paralogs for DRAXIN Gene

Variants for DRAXIN Gene

Sequence variations from dbSNP and Humsavar for DRAXIN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs745806 -- 11,697,946(-) GGTGC(A/G)TTGAT intron-variant
rs988333 -- 11,694,530(-) CTAAG(C/T)GATCA intron-variant
rs998246 -- 11,715,714(-) CAGCA(C/T)ACTTA intron-variant
rs1534986 -- 11,714,225(-) TGTTG(C/T)GCttt intron-variant
rs1534987 -- 11,701,767(-) CAGGC(A/G)GAAGG intron-variant

Variation tolerance for DRAXIN Gene

Residual Variation Intolerance Score: 89.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRAXIN Gene

HapMap Linkage Disequilibrium report
DRAXIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DRAXIN Gene

Disorders for DRAXIN Gene

Relevant External Links for DRAXIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRAXIN
genes like me logo Genes that share disorders with DRAXIN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRAXIN Gene

Publications for DRAXIN Gene

  1. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. (PMID: 19150847) Islam S.M. … Tanaka H. (Science 2009) 2 67
  2. A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. (PMID: 26190107) Gao X. … SAPllner C. (Cell Rep 2015) 67
  3. Inhibitory effects of draxin on axonal outgrowth and migration of precerebellar neurons. (PMID: 24832731) Riyadh M.A. … Tanaka H. (Biochem. Biophys. Res. Commun. 2014) 67
  4. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. (PMID: 19857465) Miyake A. … Itoh N. (Biochem. Biophys. Res. Commun. 2009) 67
  5. Genomewide association for schizophrenia in the CATIE study: results of stage 1. (PMID: 18347602) Sullivan P.F. … Close S.L. (Mol. Psychiatry 2008) 67

Products for DRAXIN Gene

Sources for DRAXIN Gene

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