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Aliases for DRAP1 Gene

Aliases for DRAP1 Gene

  • DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) 2 3
  • Negative Cofactor 2 Alpha 2 3
  • Negative Cofactor 2-Alpha 3 4
  • NC2-Alpha 3 4
  • DR1-Associated Corepressor 2
  • Dr1-Associated Corepressor 3
  • Negative Co-Factor 2-Alpha 3
  • Dr1-Associated Protein 1 4

External Ids for DRAP1 Gene

Previous GeneCards Identifiers for DRAP1 Gene

  • GC11P068221
  • GC11P067368
  • GC11P065462
  • GC11P065443
  • GC11P065686
  • GC11P062013

Summaries for DRAP1 Gene

Entrez Gene Summary for DRAP1 Gene

  • Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRAP1 Gene

DRAP1 (DR1-Associated Protein 1 (Negative Cofactor 2 Alpha)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for DRAP1 Gene

  • The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.

Gene Wiki entry for DRAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAP1 Gene

Genomics for DRAP1 Gene

Regulatory Elements for DRAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DRAP1 Gene

Start:
65,919,257 bp from pter
End:
65,921,577 bp from pter
Size:
2,321 bases
Orientation:
Plus strand

Genomic View for DRAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRAP1 Gene

Proteins for DRAP1 Gene

  • Protein details for DRAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14919-NC2A_HUMAN
    Recommended name:
    Dr1-associated corepressor
    Protein Accession:
    Q14919
    Secondary Accessions:
    • Q13448

    Protein attributes for DRAP1 Gene

    Size:
    205 amino acids
    Molecular mass:
    22350 Da
    Quaternary structure:
    • Heterodimer with DR1. Binds BTAF1.

    Three dimensional structures from OCA and Proteopedia for DRAP1 Gene

    Alternative splice isoforms for DRAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRAP1 Gene

Proteomics data for DRAP1 Gene at MOPED

Post-translational modifications for DRAP1 Gene

  • Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRAP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DRAP1 Gene

Domains for DRAP1 Gene

Protein Domains for DRAP1 Gene

Suggested Antigen Peptide Sequences for DRAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14919

UniProtKB/Swiss-Prot:

NC2A_HUMAN :
  • Q14919
Domain:
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the NC2 alpha/DRAP1 family.
genes like me logo Genes that share domains with DRAP1: view

No data available for Gene Families for DRAP1 Gene

Function for DRAP1 Gene

Molecular function for DRAP1 Gene

GENATLAS Biochemistry: Dr1-associated polypeptide,corepressor of transcription,expressed with higher levels in tissues with low mitotic index
UniProtKB/Swiss-Prot Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.

Gene Ontology (GO) - Molecular Function for DRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8670811
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8608938
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with DRAP1: view

Phenotypes for DRAP1 Gene

MGI mutant phenotypes for DRAP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for DRAP1:
genes like me logo Genes that share phenotypes with DRAP1: view

Animal Models for DRAP1 Gene

MGI Knock Outs for DRAP1:

Animal Model Products

CRISPR Products

miRNA for DRAP1 Gene

miRTarBase miRNAs that target DRAP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DRAP1 Gene

Localization for DRAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRAP1 Gene COMPARTMENTS Subcellular localization image for DRAP1 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DRAP1: view

Pathways for DRAP1 Gene

genes like me logo Genes that share pathways with DRAP1: view

Pathways by source for DRAP1 Gene

Gene Ontology (GO) - Biological Process for DRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DRAP1: view

Transcripts for DRAP1 Gene

mRNA/cDNA for DRAP1 Gene

Unigene Clusters for DRAP1 Gene

DR1-associated protein 1 (negative cofactor 2 alpha):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DRAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRAP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for DRAP1 Gene

GeneLoc Exon Structure for
DRAP1
ECgene alternative splicing isoforms for
DRAP1

Expression for DRAP1 Gene

mRNA expression in normal human tissues for DRAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DRAP1 Gene

SOURCE GeneReport for Unigene cluster for DRAP1 Gene Hs.356742

mRNA Expression by UniProt/SwissProt for DRAP1 Gene

Q14919-NC2A_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
genes like me logo Genes that share expressions with DRAP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DRAP1 Gene

Orthologs for DRAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DRAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRAP1 35
  • 97.62 (n)
  • 97.25 (a)
DRAP1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRAP1 35
  • 91.54 (n)
  • 92.68 (a)
DRAP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
DRAP1 35
  • 89.27 (n)
  • 93.17 (a)
mouse
(Mus musculus)
Mammalia Drap1 35
  • 88.58 (n)
  • 93.92 (a)
Drap1 16
Drap1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRAP1 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drap1 35
  • 88.77 (n)
  • 94.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23737 35
tropical clawed frog
(Silurana tropicalis)
Amphibia drap1 35
  • 69.84 (n)
  • 67.62 (a)
MGC75665 35
zebrafish
(Danio rerio)
Actinopterygii Dr.719 35
drap1 35
  • 76.73 (n)
  • 84.02 (a)
drap1 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NC2alpha 36
  • 27 (a)
OneToOne
NC2alpha 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea drap-1 36
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUR6 36
  • 27 (a)
OneToOne
BUR6 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.259 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9522 36
  • 30 (a)
OneToOne
Species with no ortholog for DRAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRAP1 Gene

ENSEMBL:
Gene Tree for DRAP1 (if available)
TreeFam:
Gene Tree for DRAP1 (if available)

Paralogs for DRAP1 Gene

No data available for Paralogs for DRAP1 Gene

Variants for DRAP1 Gene

Sequence variations from dbSNP and Humsavar for DRAP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1055612 -- 65,921,359(+) CGCCT(C/T)TACTC reference, missense
rs3782083 -- 65,921,833(-) tcaag(C/T)gattc downstream-variant-500B
rs9326360 -- 65,917,384(+) TTCAT(A/G)GGACA upstream-variant-2KB
rs9667389 -- 65,917,458(+) GCCCC(C/T)CTAGG upstream-variant-2KB
rs11358680 -- 65,921,918(+) ATGTC(-/A)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DRAP1 Gene

Variant ID Type Subtype PubMed ID
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv832191 CNV Loss 17160897
nsv897767 CNV Loss 21882294

Relevant External Links for DRAP1 Gene

HapMap Linkage Disequilibrium report
DRAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAP1 Gene

Disorders for DRAP1 Gene

No disorders were found for DRAP1 Gene.

No data available for UniProtKB/Swiss-Prot for DRAP1 Gene

Publications for DRAP1 Gene

  1. NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. (PMID: 15509807) Klejman M.P. … Timmers H.T.M. (Mol. Cell. Biol. 2004) 3 4 23
  2. Requirement of a corepressor for Dr1-mediated repression of transcription. (PMID: 8608938) Mermelstein F. … Reinberg D. (Genes Dev. 1996) 2 3 4
  3. A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. (PMID: 8670811) Goppelt A.R. … Meisterernst M. (EMBO J. 1996) 3 4
  4. Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. (PMID: 11461703) Kamada K. … Burley S.K. (Cell 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DRAP1 Gene

Sources for DRAP1 Gene

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