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Aliases for DRAM2 Gene

Aliases for DRAM2 Gene

  • DNA-Damage Regulated Autophagy Modulator 2 2 3
  • Transmembrane Protein 77 2 3 4
  • TMEM77 3 4 6
  • DNA Damage-Regulated Autophagy Modulator Protein 2 3
  • Damage Regulated Autophagy Modulator 2 3
  • RP5-1180E21.1 3
  • WWFQ154 3
  • PRO180 3

External Ids for DRAM2 Gene

Previous Symbols for DRAM2 Gene

  • TMEM77

Summaries for DRAM2 Gene

GeneCards Summary for DRAM2 Gene

DRAM2 (DNA-Damage Regulated Autophagy Modulator 2) is a Protein Coding gene. An important paralog of this gene is DRAM1.

UniProtKB/Swiss-Prot for DRAM2 Gene

  • Induces apoptotic cell death when coexpressed with DRAM1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAM2 Gene

Genomics for DRAM2 Gene

Genomic Location for DRAM2 Gene

Start:
111,117,332 bp from pter
End:
111,140,216 bp from pter
Size:
22,885 bases
Orientation:
Minus strand

Genomic View for DRAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRAM2 Gene

No data available for Regulatory Elements for DRAM2 Gene

Proteins for DRAM2 Gene

  • Protein details for DRAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX65-DRAM2_HUMAN
    Recommended name:
    DNA damage-regulated autophagy modulator protein 2
    Protein Accession:
    Q6UX65
    Secondary Accessions:
    • B3SUG9
    • Q4VWF6
    • Q86VD3
    • Q8NBQ4

    Protein attributes for DRAM2 Gene

    Size:
    266 amino acids
    Molecular mass:
    29766 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11562.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DRAM2 Gene

Proteomics data for DRAM2 Gene at MOPED

Post-translational modifications for DRAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRAM2 Gene

Domains for DRAM2 Gene

Protein Domains for DRAM2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DRAM2_HUMAN
Family:
  • Belongs to the DRAM/TMEM150 family.:
    • Q6UX65
genes like me logo Genes that share domains with DRAM2: view

No data available for Gene Families for DRAM2 Gene

Function for DRAM2 Gene

Molecular function for DRAM2 Gene

UniProtKB/Swiss-Prot Function: Induces apoptotic cell death when coexpressed with DRAM1.
UniProtKB/Swiss-Prot Induction: Not induced by p53/TP53 or TP73/p73.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DRAM2 Gene

Localization for DRAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAM2 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRAM2 Gene COMPARTMENTS Subcellular localization image for DRAM2 gene
Compartment Confidence
lysosome 5
vacuole 5
golgi apparatus 4
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for DRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19895784
GO:0005764 lysosome IDA 19556885
GO:0005765 lysosomal membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with DRAM2: view

Pathways for DRAM2 Gene

SuperPathways for DRAM2 Gene

No Data Available

Interacting Proteins for DRAM2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000286692%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000286692 Q6UX65-DRAM2_HUMAN for DRAM2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0010506 regulation of autophagy IDA 19895784
genes like me logo Genes that share ontologies with DRAM2: view

No data available for Pathways by source for DRAM2 Gene

Transcripts for DRAM2 Gene

Unigene Clusters for DRAM2 Gene

DNA-damage regulated autophagy modulator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRAM2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - -
SP10: - -
SP11: -
SP12: - -
SP13:

Relevant External Links for DRAM2 Gene

GeneLoc Exon Structure for
DRAM2
ECgene alternative splicing isoforms for
DRAM2

Expression for DRAM2 Gene

mRNA expression in normal human tissues for DRAM2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DRAM2 Gene

SOURCE GeneReport for Unigene cluster for DRAM2 Gene Hs.485606

mRNA Expression by UniProt/SwissProt for DRAM2 Gene

Q6UX65-DRAM2_HUMAN
Tissue specificity: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus.
genes like me logo Genes that share expressions with DRAM2: view

Orthologs for DRAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRAM2 36
  • 100 (n)
  • 100 (a)
DRAM2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRAM2 36
  • 92.61 (n)
  • 90.23 (a)
DRAM2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRAM2 36
  • 91.85 (n)
  • 91.73 (a)
DRAM2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dram2 36
  • 88.43 (n)
  • 86.42 (a)
Dram2 16
Dram2 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRAM2 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRAM2 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dram2 36
  • 87.92 (n)
  • 86.04 (a)
chicken
(Gallus gallus)
Aves DRAM2 36
  • 66.17 (n)
  • 62.03 (a)
lizard
(Anolis carolinensis)
Reptilia DRAM2 37
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dram2a 37
  • 48 (a)
OneToMany
dram2b 36
  • 57.3 (n)
  • 55.42 (a)
dram2b 37
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4025 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33A11.2 36
  • 42.81 (n)
  • 32 (a)
C33A11.2 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2907 37
  • 44 (a)
OneToOne
Species with no ortholog for DRAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DRAM2 Gene

ENSEMBL:
Gene Tree for DRAM2 (if available)
TreeFam:
Gene Tree for DRAM2 (if available)

Paralogs for DRAM2 Gene

Paralogs for DRAM2 Gene

Selected SIMAP similar genes for DRAM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DRAM2: view

Variants for DRAM2 Gene

Sequence variations from dbSNP and Humsavar for DRAM2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11002 -- 111,117,918(-) AAGTC(A/G)AAAGA utr-variant-3-prime
rs182732 -- 111,133,975(-) GAGGA(A/T)GAGAA intron-variant
rs325913 -- 111,116,879(+) TTATT(C/T)CTTGA downstream-variant-500B
rs325914 -- 111,117,375(+) CCCAA(A/C)CTTCT utr-variant-3-prime
rs325916 -- 111,118,791(-) GCACA(A/G)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRAM2 Gene

Variant ID Type Subtype PubMed ID
nsv872149 CNV Loss 21882294
nsv10639 CNV Gain 18304495

Relevant External Links for DRAM2 Gene

HapMap Linkage Disequilibrium report
DRAM2

Disorders for DRAM2 Gene

Relevant External Links for DRAM2

Genetic Association Database (GAD)
DRAM2
Human Genome Epidemiology (HuGE) Navigator
DRAM2
genes like me logo Genes that share disorders with DRAM2: view

No data available for UniProtKB/Swiss-Prot for DRAM2 Gene

Publications for DRAM2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. (PMID: 19556885) O'Prey J. … Ryan K.M. (Cell Cycle 2009) 3 4

Products for DRAM2 Gene

Sources for DRAM2 Gene

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