DRAM2 Gene
protein-coding GIFtS : 46
GCID: GC01 M111659
DNA-damage regulated autophagy modulator 2 (Previous name: transmembrane protein 77 ) (Previous symbol: TMEM77 )
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Aliasesfor DRAM2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DNA-Damage Regulated Autophagy Modulator 2 1 2 WWFQ1541 2 TMEM771 2 3 5 MGC542891 Transmembrane Protein 771 2 3 Damage Regulated Autophagy Modulator 22 PRO1801 2 DNA Damage-Regulated Autophagy Modulator Protein 22 RP5-1180E21.11 2
Export aliases for DRAM2 gene to outside databases Previous GC identifers: GC01M111461 GC01M109531
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Summariesfor DRAM2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Function : Induces apoptotic cell death when coexpressed with DRAM1
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Genomic Viewsfor DRAM2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for DRAM2 Other transcription factors Search SABiosciences Chromatin IP Primers for DRAM2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DRAM2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3 DRAM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M111659: view genomic region
(about GC identifiers )
Start:
111,659,954 bp from pter
End:
111,682,838 bp from pter
Size:
22,885 bases
Orientation:
minus strand
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Proteinsfor DRAM2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 (See
protein sequence )Recommended Name: DNA damage-regulated autophagy modulator protein 2 Size : 266 amino acids; 29766 Da
Subcellular location : Lysosome membrane; Multi-pass membrane protein
Sequence caution : Sequence=BAC11562.1; Type=Erroneous initiation;
Secondary accessions : B3SUG9 Q4VWF6 Q86VD3 Q8NBQ4Explore the universe of human proteins at neXtProt for DRAM2: NX_Q6UX65 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6UX65 DRAM2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_848549.3 ENSEMBL proteins: ENSP00000286692 ENSP00000437718 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
DRAM2 for ontologies About GeneDecksing DRAM2 Antibody Products: Assay Products for DRAM2:
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Protein
Domains / Familiesfor DRAM2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DRAM2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6UX65 ProtoNet protein and cluster: Q6UX65
UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Similarity : Belongs to the DRAM/TMEM150 family
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Functionfor DRAM2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Function : Induces apoptotic cell death when coexpressed with DRAM1Induction : Not induced by p53/TP53 or TP73/p73
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DRAM2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DRAM2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DRAM2 (NM_178454 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DRAM2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DRAM2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM2
Animal Models: Mouse knock-out Dram2 tm1Lex for DRAM2 1 MGI phenotypic allele for Dram2 (no phenotypes)
DRAM2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor DRAM2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DRAM2 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for DRAM2 (Q6UX65 3 ENSP00000286692 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
DRAM2 for ontologies About GeneDecksing
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Drugs & Compoundsfor DRAM2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DRAM2 Search CenterWatch for drugs/clinical trials and news about DRAM2
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Transcriptsfor DRAM2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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GenScript ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DRAM2 gene: NM_178454.4 Unigene Cluster for DRAM2:
DNA-damage regulated autophagy modulator 2 Hs.485606 [show with all ESTs ] Unigene Representative Sequence: AK092961 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000286692 (uc001eae.4 ) ENST00000484310 ENST00000496430 ENST00000461449 ENST00000477588 ENST00000477769 ENST00000480600 ENST00000462092 ENST00000490780 ENST00000463682 ENST00000539140 (uc001ead.4 uc009wfy.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DRAM2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DRAM2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DRAM2 (NM_178454 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DRAM2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DRAM2
Additional cDNA sequence: AK075350.1 AK092961.1 AK309557.1 AL833098.1 AY336747.1 AY358492.1 BC047025.1 BC091509.1 EF710624.1
24/28 DOTS entries (see all 28 ): DT.100883773 DT.95155118
DT.102837002 DT.100883775 DT.208306 DT.100717399 DT.100883777 DT.100705590 DT.92447452 DT.100883780 DT.121409427 DT.100830893 DT.437327 DT.100883779 DT.95155125 DT.121409467 DT.91740571 DT.92447467 DT.100883778 DT.121409308 DT.121409332 DT.409117 DT.97845083 DT.100691333 24/257 AceView cDNA sequences (see all 257 ):
AI088857 AA991257 AA594963 BM784358 AA807741 AW675383 AV711819 AA507967 CR613969 AI783537 AW068971 CA311750 CR602380 AA459282 BU956507 CR598225 AA613581 CA941868 BQ067934 BU069696 BG496936 BC047025 BU626796 CR626576 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DRAM2 (see all 13 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c SP1 :         -   -   -         -   -   -       -   -                   SP2 :         -   -   -         -   -   -   -   -   -   -                   SP3 :         -   -   -         -   -   -   -   -     -                   SP4 :         -             -   -   -   -   -   -   -                   SP5 :         -             -   -   -       -   -                  
ECgene alternative splicing isoforms for DRAM2
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Expression for DRAM2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DRAM2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAGAAGCCA
About this image DRAM2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Adipose Body Subcutaneous White Adipose Adipose Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DRAM2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DRAM2 SOURCE GeneReport for Unigene cluster: Hs.485606 UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 Tissue specificity : Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highestlevels in placenta and heart. Not detected in brain or thymus SABiosciences Expression via Pathway-Focused PCR Array including DRAM2 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DRAM2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DRAM2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DRAM2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DRAM2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM2
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Orthologsfor DRAM2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for DRAM2 gene from 4/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for DRAM2 (if available)TreeFam Gene Tree for DRAM2 (if available)
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Paralogsfor DRAM2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DRAM2 gene TMEM150A 2 DRAM1 2 TMEM150C 2 TMEM150B 2 1 SIMAP similar gene for DRAM2 using alignment to 1 protein entry: DRAM2_HUMAN :DRAM1
DRAM2 for paralogs About GeneDecksing
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Genomic Variantsfor DRAM2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DRAM2 (111659954 - 111682838 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DRAM2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DRAM2
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Disorders
/ Diseasesfor DRAM2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DRAM2 for disorders About MalaCards
DRAM2 for disorders About GeneDecksing
OMIM gene information: 613360
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: DRAM2 (1 document)Export disorders for DRAM2 gene to outside databases
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Publicationsfor DRAM2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DRAM2 gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with DRAM2) Utopia : connect your pdf to the dynamic world of online information
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) Analysis of DRAM-related proteins reveals evolutionar ily conserved and divergent roles in the control of autophagy. (PubMed id 19556885) 1 , 2 O'Prey J....Ryan K.M. (2009) Reduced expression of DRAM2/TMEM77 in tumor cells int erferes with cell death. (PubMed id 19895784) 1 , 2 Park S.M....Park J. (2009) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743) 1 , 2 Otsuki T....Isogai T. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction. (PubMed id 21584698) 1 Yoon J.H....Park J. (2012) Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757) 1 Chambers J.C....Kooner J.S. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009)
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External Searches for DRAM2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DRAM2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DRAM2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DRAM2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DRAM2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DRAM2 gene: Search GeneIP for patents involving DRAM2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DRAM2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DRAM2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DRAM2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DRAM2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DRAM2 OriGene 3'-UTR Clone for DRAM2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DRAM2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DRAM2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DRAM2 OriGene Custom Protein Services for DRAM2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DRAM2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DRAM2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DRAM2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DRAM2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DRAM2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DRAM2
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DRAM2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM2
Search ThermoFisher Antibodies for DRAM2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DRAM2
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Aliases for DRAM2
Databases for DRAM2
Disorders / Diseases for DRAM2
Domains / Families for DRAM2
Drugs / Compounds for DRAM2
Expression for DRAM2
Function for DRAM2
Genomic Views for DRAM2
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Orthologs for DRAM2
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