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DRAM2 Gene

protein-coding   GIFtS: 48
GCID: GC01M111659

DNA-Damage Regulated Autophagy Modulator 2

(Previous name: transmembrane protein 77)
(Previous symbol: TMEM77)
  Search for DRAM2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNA-Damage Regulated Autophagy Modulator 21 2     RP5-1180E21.12
TMEM771 2 3 5     WWFQ1542
Transmembrane Protein 771 2 3     Damage Regulated Autophagy Modulator 22
PRO1802     DNA Damage-Regulated Autophagy Modulator Protein 22

External Ids:    HGNC: 287691   Entrez Gene: 1283382   Ensembl: ENSG000001561717   OMIM: 6133605   UniProtKB: Q6UX653   

Export aliases for DRAM2 gene to outside databases

Previous GC identifers: GC01M111461 GC01M109531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DRAM2 Gene:
DRAM2 (DNA-damage regulated autophagy modulator 2) is a protein-coding gene. An important paralog of this gene is DRAM1.

UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65
Function: Induces apoptotic cell death when coexpressed with DRAM1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DRAM2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRAM2 promoter sequence
   Search Chromatin IP Primers for DRAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

DRAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRAM2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111659:  view genomic region     (about GC identifiers)

Start:
111,659,954 bp from pter      End:
111,682,838 bp from pter
Size:
22,885 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65 (See protein sequence)
Recommended Name: DNA damage-regulated autophagy modulator protein 2  
Size: 266 amino acids; 29766 Da
Sequence caution: Sequence=BAC11562.1; Type=Erroneous initiation;
Secondary accessions: B3SUG9 Q4VWF6 Q86VD3 Q8NBQ4

Explore the universe of human proteins at neXtProt for DRAM2: NX_Q6UX65

Explore proteomics data for DRAM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DRAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848549.3  
    ENSEMBL proteins: 
     ENSP00000286692   ENSP00000473779   ENSP00000437718  

    DRAM2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DRAM2

     
    Search eBioscience for Proteins for DRAM2 

    DRAM2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DRAM2
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    OriGene Custom Antibody Services for DRAM2
    Novus Biologicals DRAM2 Antibody
    Abcam antibodies for DRAM2
    Cloud-Clone Corp. Antibodies for DRAM2
    Search ThermoFisher Antibodies for DRAM2
    LSBio Antibodies in human, mouse, rat for DRAM2

    DRAM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DRAM2
    Cloud-Clone Corp. CLIAs for DRAM2
    Search eBioscience for ELISAs for DRAM2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR019402 Frag1/DRAM/Sfk1
     IPR027315 DRAM/TMEM150

    Graphical View of Domain Structure for InterPro Entry Q6UX65

    ProtoNet protein and cluster: Q6UX65

    UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65
    Similarity: Belongs to the DRAM/TMEM150 family


    Find genes that share domains with DRAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRAM2_HUMAN, Q6UX65
    Function: Induces apoptotic cell death when coexpressed with DRAM1
    Induction: Not induced by p53/TP53 or TP73/p73

    Phenotypes:
         1 MGI phenotypic allele for Dram2 (no phenotypes)


    Find genes that share phenotypes with DRAM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dram2tm1Lex for DRAM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRAM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DRAM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRAM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRAM2

    miRNA
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    Block miRNA regulation of human, mouse, rat DRAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DRAM2 (see all 13):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-3647-3p hsa-miR-135b hsa-miR-501-5p hsa-miR-125b hsa-miR-670
    SwitchGear 3'UTR luciferase reporter plasmidDRAM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DRAM2
    Predesigned siRNA for gene silencing in human, mouse, rat DRAM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DRAM2

    Clone
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    OriGene clones in human, mouse for DRAM2 (see all 6)
    OriGene ORF clones in mouse, rat for DRAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DRAM2 (NM_178454)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRAM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DRAM2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DRAM2_HUMAN, Q6UX65: Lysosome membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    golgi apparatus4
    plasma membrane3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19895784
    GO:0005764lysosome IDA19556885
    GO:0005765lysosomal membrane IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with DRAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DRAM2: 
              Autophagy in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DRAM2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DRAM2 (Q6UX653 ENSP000002866924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C12orf4Q9NQ893I2D: score=5 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030262apoptotic nuclear changes IDA19895784
    GO:0097194execution phase of apoptosis IC19895784

    Find genes that share ontologies with DRAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DRAM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DRAM2 gene: 
    NM_178454.4  

    Unigene Cluster for DRAM2:

    DNA-damage regulated autophagy modulator 2
    Hs.485606  [show with all ESTs]
    Unigene Representative Sequence: AK092961
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286692(uc001eae.4) ENST00000484310 ENST00000461449 ENST00000496430
    ENST00000477588 ENST00000477769 ENST00000480600 ENST00000462092 ENST00000490780
    ENST00000463682 ENST00000539140(uc001ead.4 uc009wfy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DRAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DRAM2 (see all 13):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-3647-3p hsa-miR-135b hsa-miR-501-5p hsa-miR-125b hsa-miR-670
    SwitchGear 3'UTR luciferase reporter plasmidDRAM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DRAM2
    Predesigned siRNA for gene silencing in human, mouse, rat DRAM2
    Clone
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    OriGene clones in human, mouse for DRAM2 (see all 6)
    OriGene ORF clones in mouse, rat for DRAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DRAM2 (NM_178454)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRAM2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DRAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for DRAM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRAM2
      QuantiTect SYBR Green Assays in human, mouse, rat DRAM2
      QuantiFast Probe-based Assays in human, mouse, rat DRAM2

    Additional mRNA sequence: 

    AK075350.1 AK092961.1 AK309557.1 AL833098.1 AY336747.1 AY358492.1 BC047025.1 BC091509.1 
    EF710624.1 

    Selected DOTS entries (see all 28):

    DT.100883773  DT.95155118  DT.102837002  DT.100883775  DT.208306  DT.100717399  DT.100883777  DT.100705590 
    DT.92447452  DT.100883780  DT.121409427  DT.100830893  DT.437327  DT.100883779  DT.95155125  DT.121409467 
    DT.91740571  DT.92447467  DT.100883778  DT.121409308  DT.121409332  DT.409117  DT.97845083  DT.100691333 

    Selected AceView cDNA sequences (see all 257):

    AW675383 BQ067934 AA594963 AA613581 AA991257 BU069696 CA311750 AI088857 
    CR602380 AW068971 CR613969 BM784358 CA941868 BG496936 BC047025 BU626796 
    CR626576 BI712085 BG696703 CB141484 BG939510 BQ285877 BU621312 CD671123 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DRAM2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                          -     -     -                       -     -     -                 -     -                                                   
    SP2:                          -     -     -                       -     -     -     -     -     -     -                                                   
    SP3:                          -     -     -                       -     -     -     -     -           -                                                   
    SP4:                          -                                   -     -     -     -     -     -     -                                                   
    SP5:                          -                                   -     -     -                 -     -                                                   


    ECgene alternative splicing isoforms for DRAM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DRAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAGCCA
    DRAM2 Expression
    About this image

    DRAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DRAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485606

    UniProtKB/Swiss-Prot: DRAM2_HUMAN, Q6UX65
    Tissue specificity: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with
    highest levels in placenta and heart. Not detected in brain or thymus

        Pathway & Disease-focused RT2 Profiler PCR Array including DRAM2: 
              Autophagy in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DRAM2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRAM2
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    QuantiFast Probe-based Assays in human, mouse, rat DRAM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DRAM2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dram21 , 5 DNA-damage regulated autophagy modulator 21, 5 88.43(n)1
    86.42(a)1
      3 (46.50 cM)5
    671711  NM_026013.31  NP_080289.11 
     1065476935 
    chicken
    (Gallus gallus)
    Aves DRAM21 DNA-damage regulated autophagy modulator 2 66.17(n)
    62.03(a)
      421151  XM_003642714.2  XP_003642762.1 
    lizard
    (Anolis carolinensis)
    Reptilia DRAM26
    DNA-damage regulated autophagy modulator 2
    62(a)
    1 ↔ 1
    4(133004803-133019387)
    zebrafish
    (Danio rerio)
    Actinopterygii dram2b1 DNA-damage regulated autophagy modulator 2b 57.3(n)
    55.42(a)
      415225  NM_001002135.1  NP_001002135.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40256
    --
    31(a)
    1 → many
    X(1970999-1972488)
    worm
    (Caenorhabditis elegans)
    Secernentea C33A11.21 C33A11.2 42.81(n)
    32(a)
      181626  NM_078140.4  NP_510541.1 


    ENSEMBL Gene Tree for DRAM2 (if available)
    TreeFam Gene Tree for DRAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DRAM2 gene
    DRAM12  
    2 SIMAP similar genes for DRAM2 using alignment to 2 protein entries:     DRAM2_HUMAN (see all proteins):
    DRAM1    TMEM150B

    Find genes that share paralogs with DRAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DRAM2 (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3259131,2
    C,F,O,H--111659501(+) TTATTC/TCTTGA 1 -- int120Minor allele frequency- T:0.05MN NA NS EA WA 2560
    rs1168833111,2
    C,F--111659718(+) AGATCC/TAAGGA 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1855027101,2
    C--111659764(+) GAGAAC/TACTGT 1 -- int10--------
    rs22785781,2
    C,F,O,H--111659792(+) TCACAC/ATTATT 1 -- int131Minor allele frequency- A:0.21EA NA NS WA 4798
    rs1903770911,2
    --111659882(+) TCAATA/GTTTAC 1 -- int10--------
    rs1419103631,2
    --111659931(+) ATAAAC/TGAAAA 1 -- int10--------
    rs1506648261,2
    --111659934(+) AATGAA/TAATCT 1 -- int10--------
    rs3259141,2
    C,F,O,H--111659997(+) CCCAAA/CCTTCT 1 -- ut3131Minor allele frequency- C:0.06EA NA NS 4888
    rs1401547751,2
    --111660075(+) CCTCTC/TTCCTT 1 -- ut310--------
    rs1438531891,2
    C--111660083(+) CTTCAA/TTGGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DRAM2 (111659954 - 111682838 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DRAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872149CNV Loss21882294
    nsv10639CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DRAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for DRAM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613360    OMIM disorders: --


    Find genes that share disorders with DRAM2           About GenesLikeMe

    Genetic Association Database (GAD): DRAM2
    Human Genome Epidemiology (HuGE) Navigator: DRAM2 (1 document)

    Export disorders for DRAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DRAM2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with DRAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. (PubMed id 19556885)1, 2 O'Prey J.... Ryan K.M. (Cell Cycle 2009)
    5. Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death. (PubMed id 19895784)1, 2 Park S.M.... Park J. (Biochem. Biophys. Res. Commun. 2009)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction. (PubMed id 21584698)1 Yoon J.H....Park J. (Mol. Biol. Rep. 2012)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 128338 HGNC: 28769 AceView: MGC54289 Ensembl:ENSG00000156171 euGenes: HUgn128338
    ECgene: DRAM2 H-InvDB: DRAM2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DRAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DRAM2 gene:
    Search GeneIP for patents involving DRAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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