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Aliases for DRAM2 Gene

Aliases for DRAM2 Gene

  • DNA Damage Regulated Autophagy Modulator 2 2 3 5
  • Transmembrane Protein 77 2 3 4
  • TMEM77 3 4
  • DNA Damage-Regulated Autophagy Modulator Protein 2 3
  • DNA-Damage Regulated Autophagy Modulator 2 2
  • Damage Regulated Autophagy Modulator 2 3
  • WWFQ154 3
  • CORD21 3
  • PRO180 3

External Ids for DRAM2 Gene

Previous HGNC Symbols for DRAM2 Gene

  • TMEM77

Previous GeneCards Identifiers for DRAM2 Gene

  • GC01M111461
  • GC01M111659
  • GC01M109531

Summaries for DRAM2 Gene

Entrez Gene Summary for DRAM2 Gene

  • The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]

GeneCards Summary for DRAM2 Gene

DRAM2 (DNA Damage Regulated Autophagy Modulator 2) is a Protein Coding gene. Diseases associated with DRAM2 include Cone-Rod Dystrophy 21 and Fundus Dystrophy. An important paralog of this gene is DRAM1.

UniProtKB/Swiss-Prot for DRAM2 Gene

  • Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAM2 Gene

Genomics for DRAM2 Gene

Regulatory Elements for DRAM2 Gene

Enhancers for DRAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G111189 2 FANTOM5 Ensembl ENCODE dbSUPER 39.2 -57.9 -57885 16.6 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DRAM2 CEPT1 CHI3L2 DDX20 DENND2D CD53 LRIF1 RAP1A C1orf162 PIR46223
GH01G111138 1.4 ENCODE dbSUPER 39.9 -0.5 -510 4.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B DRAM2 DENND2D CHI3L2 OVGP1 LOC440600 ENSG00000272982
GH01G111181 0.8 dbSUPER 39 -45.3 -45328 8.4 BCOR CTCF FOXA2 ZSCAN4 BACH1 ZMYM3 KLF17 NFXL1 ZIC2 RAD21 DRAM2 OVGP1 ENSG00000273221 PIR46223
GH01G111126 1.4 Ensembl ENCODE dbSUPER 10.3 +11.6 11604 3.7 HDAC1 TBP PKNOX1 TCF12 RELB ETV6 IKZF2 CREM CEBPB TBX21 DRAM2 LOC440600 CEPT1 RNA5SP54
GH01G111110 0.8 ENCODE 17.8 +29.8 29803 0.2 ELF3 TFAP4 FOXA2 SAP130 ARID4B CEBPG ZNF644 ZNF48 RAD21 RARA DRAM2 CEPT1 RNA5SP54
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DRAM2 on UCSC Golden Path with GeneCards custom track

Promoters for DRAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DRAM2 Gene

111,117,332 bp from pter
111,140,216 bp from pter
22,885 bases
Minus strand

Genomic View for DRAM2 Gene

Genes around DRAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRAM2 Gene

Proteins for DRAM2 Gene

  • Protein details for DRAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA damage-regulated autophagy modulator protein 2
    Protein Accession:
    Secondary Accessions:
    • B3SUG9
    • Q4VWF6
    • Q86VD3
    • Q8NBQ4

    Protein attributes for DRAM2 Gene

    266 amino acids
    Molecular mass:
    29766 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11562.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DRAM2 Gene

Post-translational modifications for DRAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DRAM2 Gene

Domains & Families for DRAM2 Gene

Protein Domains for DRAM2 Gene


Suggested Antigen Peptide Sequences for DRAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DRAM/TMEM150 family.
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with DRAM2: view

No data available for Gene Families for DRAM2 Gene

Function for DRAM2 Gene

Molecular function for DRAM2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
UniProtKB/Swiss-Prot Induction:
Not induced by p53/TP53 or TP73/p73.
genes like me logo Genes that share phenotypes with DRAM2: view

Human Phenotype Ontology for DRAM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for DRAM2

CRISPR Products

miRNA for DRAM2 Gene

miRTarBase miRNAs that target DRAM2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DRAM2 Gene

Localization for DRAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAM2 Gene

Lysosome membrane; Multi-pass membrane protein. Photoreceptor inner segment. Apical cell membrane. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000250 UniProtKB:Q9CR48}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRAM2 gene
Compartment Confidence
plasma membrane 5
lysosome 5
golgi apparatus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for DRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001917 photoreceptor inner segment ISS --
GO:0005737 cytoplasm IDA 19895784
GO:0005764 lysosome IEA,IDA 19556885
GO:0005765 lysosomal membrane IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with DRAM2: view

Pathways & Interactions for DRAM2 Gene

SuperPathways for DRAM2 Gene

No Data Available

Interacting Proteins for DRAM2 Gene

Selected Interacting proteins: Q6UX65-DRAM2_HUMAN for DRAM2 Gene via IID

Gene Ontology (GO) - Biological Process for DRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0007601 visual perception IMP 25983245
GO:0010506 regulation of autophagy IDA 19895784
GO:0045494 photoreceptor cell maintenance IMP 25983245
genes like me logo Genes that share ontologies with DRAM2: view

No data available for Pathways by source and SIGNOR curated interactions for DRAM2 Gene

Drugs & Compounds for DRAM2 Gene

No Compound Related Data Available

Transcripts for DRAM2 Gene

Unigene Clusters for DRAM2 Gene

DNA-damage regulated autophagy modulator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRAM2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - -
SP10: - -
SP11: -
SP12: - -

Relevant External Links for DRAM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRAM2 Gene

Protein differential expression in normal tissues from HIPED for DRAM2 Gene

This gene is overexpressed in Lung (26.5), Islet of Langerhans (17.6), and Blymphocyte (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DRAM2 Gene

Protein tissue co-expression partners for DRAM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DRAM2 Gene:


SOURCE GeneReport for Unigene cluster for DRAM2 Gene:


mRNA Expression by UniProt/SwissProt for DRAM2 Gene:

Tissue specificity: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Expressed in the retina. Not detected in brain or thymus.

Evidence on tissue expression from TISSUES for DRAM2 Gene

  • Nervous system(4.7)
  • Eye(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DRAM2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • lacrimal apparatus
  • pituitary gland
  • breast
  • ovary
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vulva
  • blood
  • blood vessel
  • hair
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with DRAM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DRAM2 Gene

Orthologs for DRAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRAM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DRAM2 34 35
  • 100 (n)
(Bos Taurus)
Mammalia DRAM2 34 35
  • 92.61 (n)
(Canis familiaris)
Mammalia DRAM2 34 35
  • 91.85 (n)
(Mus musculus)
Mammalia Dram2 34 16 35
  • 88.43 (n)
(Rattus norvegicus)
Mammalia Dram2 34
  • 87.92 (n)
(Monodelphis domestica)
Mammalia DRAM2 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia DRAM2 35
  • 77 (a)
(Gallus gallus)
Aves DRAM2 34
  • 66.17 (n)
(Anolis carolinensis)
Reptilia DRAM2 35
  • 62 (a)
(Danio rerio)
Actinopterygii dram2b 34 35
  • 57.3 (n)
dram2a 35
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4025 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea C33A11.2 34 35
  • 42.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2907 35
  • 44 (a)
Species where no ortholog for DRAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DRAM2 Gene

Gene Tree for DRAM2 (if available)
Gene Tree for DRAM2 (if available)

Paralogs for DRAM2 Gene

Paralogs for DRAM2 Gene

(2) SIMAP similar genes for DRAM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DRAM2: view

Variants for DRAM2 Gene

Sequence variations from dbSNP and Humsavar for DRAM2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs201422368 Pathogenic 111,120,539(+) CACAC(C/T)AGATA reference, stop-gained
rs746559651 Pathogenic 111,126,286(+) CTGTA(-/C)CAGTG reference, frameshift-variant, utr-variant-5-prime
rs786205661 Pathogenic 111,131,489(-) CTGCT(-/GCT)TTCAT cds-indel
rs786205662 Pathogenic 111,131,476(-) TTTCA(C/T)ACATT reference, missense, utr-variant-5-prime
rs786205663 Pathogenic 111,124,856(-) TTTAT(-/GTTCGTTAT)AAGCA intron-variant, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for DRAM2 Gene

Variant ID Type Subtype PubMed ID
nsv10639 CNV gain 18304495

Variation tolerance for DRAM2 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRAM2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAM2 Gene

Disorders for DRAM2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DRAM2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cone-rod dystrophy 21
  • retinal dystrophy with early macular involvement
fundus dystrophy
  • retinal dystrophy
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search DRAM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DRAM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DRAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRAM2 Gene

Publications for DRAM2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. (PMID: 25983245) El-Asrag M.E. … Ali M. (Am. J. Hum. Genet. 2015) 3 4 64
  3. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. (PMID: 19556885) O'Prey J. … Ryan K.M. (Cell Cycle 2009) 3 4 64

Products for DRAM2 Gene

Sources for DRAM2 Gene

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