Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DRAM2 Gene

Aliases for DRAM2 Gene

  • DNA Damage Regulated Autophagy Modulator 2 2 3 5
  • Transmembrane Protein 77 2 3 4
  • TMEM77 3 4
  • DNA Damage-Regulated Autophagy Modulator Protein 2 3
  • DNA-Damage Regulated Autophagy Modulator 2 2
  • Damage Regulated Autophagy Modulator 2 3
  • RP5-1180E21.1 3
  • WWFQ154 3
  • CORD21 3
  • PRO180 3

External Ids for DRAM2 Gene

Previous HGNC Symbols for DRAM2 Gene

  • TMEM77

Previous GeneCards Identifiers for DRAM2 Gene

  • GC01M111461
  • GC01M111659
  • GC01M109531

Summaries for DRAM2 Gene

GeneCards Summary for DRAM2 Gene

DRAM2 (DNA Damage Regulated Autophagy Modulator 2) is a Protein Coding gene. Diseases associated with DRAM2 include Cone-Rod Dystrophy 21 and Fundus Dystrophy. An important paralog of this gene is DRAM1.

UniProtKB/Swiss-Prot for DRAM2 Gene

  • Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAM2 Gene

Genomics for DRAM2 Gene

Regulatory Elements for DRAM2 Gene

Enhancers for DRAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F111185 1.8 FANTOM5 Ensembl ENCODE 39.2 -55.5 -55521 21.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DRAM2 KCND3-AS1 CEPT1 HIGD1AP12 NRBF2P3 CHI3L2 ENSG00000243960 DDX20 ENSG00000273373 DENND2D
GH01F111138 1.1 ENCODE 39.9 -0.5 -510 4.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SP3 DRAM2 DENND2D CHI3L2 OVGP1 LOC440600 ENSG00000272982
GH01F111110 0.8 ENCODE 17.7 +29.8 29803 0.2 ELF3 TFAP4 SAP130 ARID4B CEBPG ZNF48 ZNF644 RAD21 YY1 RARA DRAM2 CEPT1 RNA5SP54
GH01F111126 1.1 Ensembl ENCODE 10.3 +11.6 11604 3.7 HDAC1 TBP PKNOX1 ETV6 CREM TBX21 RAD51 SMARCA4 PBX2 IKZF1 DRAM2 LOC440600 CEPT1 RNA5SP54
GH01F111101 1.1 Ensembl ENCODE 10.3 +37.9 37922 1.5 HDAC1 PKNOX1 CHAMP1 NCOA1 CEBPB ZEB2 TFDP1 SMARCA4 IKZF1 CEBPA DRAM2 LOC440600 CEPT1 RNA5SP54
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DRAM2 on UCSC Golden Path with GeneCards custom track

Promoters for DRAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000284482 -184 3601 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SP3

Genomic Location for DRAM2 Gene

Chromosome:
1
Start:
111,117,332 bp from pter
End:
111,140,216 bp from pter
Size:
22,885 bases
Orientation:
Minus strand

Genomic View for DRAM2 Gene

Genes around DRAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRAM2 Gene

Proteins for DRAM2 Gene

  • Protein details for DRAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX65-DRAM2_HUMAN
    Recommended name:
    DNA damage-regulated autophagy modulator protein 2
    Protein Accession:
    Q6UX65
    Secondary Accessions:
    • B3SUG9
    • Q4VWF6
    • Q86VD3
    • Q8NBQ4

    Protein attributes for DRAM2 Gene

    Size:
    266 amino acids
    Molecular mass:
    29766 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11562.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DRAM2 Gene

Post-translational modifications for DRAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DRAM2 Gene

Domains & Families for DRAM2 Gene

Protein Domains for DRAM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX65

UniProtKB/Swiss-Prot:

DRAM2_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with DRAM2: view

No data available for Gene Families for DRAM2 Gene

Function for DRAM2 Gene

Molecular function for DRAM2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
UniProtKB/Swiss-Prot Induction:
Not induced by p53/TP53 or TP73/p73.
genes like me logo Genes that share phenotypes with DRAM2: view

Human Phenotype Ontology for DRAM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for DRAM2

miRNA for DRAM2 Gene

miRTarBase miRNAs that target DRAM2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DRAM2 Gene

Localization for DRAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAM2 Gene

Lysosome membrane; Multi-pass membrane protein. Photoreceptor inner segment. Apical cell membrane. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000250 UniProtKB:Q9CR48}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRAM2 gene
Compartment Confidence
plasma membrane 5
lysosome 5
golgi apparatus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for DRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001917 photoreceptor inner segment ISS --
GO:0005737 cytoplasm IDA 19895784
GO:0005764 lysosome IEA,IDA 19556885
GO:0005765 lysosomal membrane IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with DRAM2: view

Pathways & Interactions for DRAM2 Gene

SuperPathways for DRAM2 Gene

No Data Available

Interacting Proteins for DRAM2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000286692%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000286692 Q6UX65-DRAM2_HUMAN for DRAM2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0007601 visual perception IMP 25983245
GO:0010506 regulation of autophagy IDA 19895784
GO:0045494 photoreceptor cell maintenance IMP 25983245
genes like me logo Genes that share ontologies with DRAM2: view

No data available for Pathways by source and SIGNOR curated interactions for DRAM2 Gene

Transcripts for DRAM2 Gene

Unigene Clusters for DRAM2 Gene

DNA-damage regulated autophagy modulator 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRAM2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - -
SP10: - -
SP11: -
SP12: - -
SP13:

Relevant External Links for DRAM2 Gene

GeneLoc Exon Structure for
DRAM2
ECgene alternative splicing isoforms for
DRAM2

Expression for DRAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DRAM2 Gene

Protein differential expression in normal tissues from HIPED for DRAM2 Gene

This gene is overexpressed in Lung (26.5), Islet of Langerhans (17.6), and Blymphocyte (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DRAM2 Gene



Protein tissue co-expression partners for DRAM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DRAM2 Gene:

DRAM2

SOURCE GeneReport for Unigene cluster for DRAM2 Gene:

Hs.485606

mRNA Expression by UniProt/SwissProt for DRAM2 Gene:

Q6UX65-DRAM2_HUMAN
Tissue specificity: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Expressed in the retina. Not detected in brain or thymus.
genes like me logo Genes that share expression patterns with DRAM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DRAM2 Gene

Orthologs for DRAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRAM2 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia DRAM2 34 35
  • 92.61 (n)
dog
(Canis familiaris)
Mammalia DRAM2 34 35
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Dram2 34 16 35
  • 88.43 (n)
rat
(Rattus norvegicus)
Mammalia Dram2 34
  • 87.92 (n)
oppossum
(Monodelphis domestica)
Mammalia DRAM2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRAM2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRAM2 34
  • 66.17 (n)
lizard
(Anolis carolinensis)
Reptilia DRAM2 35
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dram2b 34 35
  • 57.3 (n)
dram2a 35
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4025 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33A11.2 34 35
  • 42.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2907 35
  • 44 (a)
OneToOne
Species where no ortholog for DRAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DRAM2 Gene

ENSEMBL:
Gene Tree for DRAM2 (if available)
TreeFam:
Gene Tree for DRAM2 (if available)

Paralogs for DRAM2 Gene

Paralogs for DRAM2 Gene

(2) SIMAP similar genes for DRAM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DRAM2: view

Variants for DRAM2 Gene

Sequence variations from dbSNP and Humsavar for DRAM2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs201422368 Pathogenic 111,120,539(+) CACAC(C/T)AGATA reference, stop-gained
rs746559651 Pathogenic 111,126,286(+) CTGTA(-/C)CAGTG reference, frameshift-variant, utr-variant-5-prime
rs786205661 Pathogenic 111,131,489(-) CTGCT(-/GCT)TTCAT cds-indel
rs786205662 Pathogenic 111,131,476(-) TTTCA(C/T)ACATT reference, missense, utr-variant-5-prime
rs786205663 Pathogenic 111,124,856(-) TTTAT(-/GTTCGTTAT)AAGCA intron-variant, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for DRAM2 Gene

Variant ID Type Subtype PubMed ID
nsv10639 CNV gain 18304495

Variation tolerance for DRAM2 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRAM2 Gene

Human Gene Mutation Database (HGMD)
DRAM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAM2 Gene

Disorders for DRAM2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DRAM2 Gene - From: OMIM, ClinVar, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 21
  • retinal dystrophy with early macular involvement
fundus dystrophy
  • retinal dystrophy
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search DRAM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DRAM2

Genetic Association Database (GAD)
DRAM2
Human Genome Epidemiology (HuGE) Navigator
DRAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRAM2
genes like me logo Genes that share disorders with DRAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRAM2 Gene

Publications for DRAM2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. (PMID: 25983245) El-Asrag M.E. … Ali M. (Am. J. Hum. Genet. 2015) 3 4 64
  3. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. (PMID: 19556885) O'Prey J. … Ryan K.M. (Cell Cycle 2009) 3 4 64

Products for DRAM2 Gene

Sources for DRAM2 Gene

Content
Loading form....