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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DRAM1 Gene

protein-coding GIFtS: 48
GCID: GC12P102271

DNA-damage regulated autophagy modulator 1

Explore 1 disease affiliated with
DRAM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DNA-Damage Regulated Autophagy Modulator 1¹ ²
DRAM¹ ² ³
Damage-Regulated Autophagy Modulator² ³
FLJ11259¹
DNA Damage-Regulated Autophagy Modulator Protein 1²

External Ids:	HGNC: 25645¹	Entrez Gene: 55332²	Ensembl: ENSG00000136048⁷	OMIM: 610776⁵	UniProtKB: Q8N682³

Export aliases for DRAM1 gene to outside databases

Previous GC identifers: GC12P100798 GC12P099330

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DRAM1:

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that

is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is

associated with various tumors. This gene has a pseudogene on chromosome 4. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DRAM1_HUMAN, Q8N682

Function: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in

p73/TP73-mediated autophagy

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for DRAM1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DRAM1 promoter sequence

Search SABiosciences Chromatin IP Primers for DRAM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRAM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2 Ensembl cytogenetic band: 12q23.2 HGNC cytogenetic band: 12q23.2

DRAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRAM1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P102271: view genomic region (about GC identifiers)

Start:	102,271,105 bp from pter	End:	102,405,908 bp from pter
Size:	134,804 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DRAM1_HUMAN, Q8N682 (See protein sequence)

Recommended Name: DNA damage-regulated autophagy modulator protein 1

Size: 238 amino acids; 26253 Da

Subcellular location: Lysosome membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAA92091.1; Type=Erroneous initiation;

Secondary accessions: Q7L3E3 Q9NUN1

Explore the universe of human proteins at neXtProt for DRAM1: NX_Q8N682

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N682

DRAM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060840.2

ENSEMBL proteins:

ENSP00000258534 ENSP00000445827 ENSP00000448075 ENSP00000447171 ENSP00000447906

Human Recombinant Protein Products for DRAM1:

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	Uscn Proteins for DRAM1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005765	lysosomal membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

DRAM1 for ontologies About GeneDecksing

DRAM1 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DRAM1 for domains About GeneDecksing

1 InterPro domain/family:

IPR019402 Frag1/DRAM/Sfk1

Graphical View of Domain Structure for InterPro Entry Q8N682

ProtoNet protein and cluster: Q8N682

UniProtKB/Swiss-Prot: DRAM1_HUMAN, Q8N682

Similarity: Belongs to the DRAM/TMEM150 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DRAM1_HUMAN, Q8N682

Function: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in

p73/TP73-mediated autophagy

Induction: By p53/TP53 and p73/TP73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines

by methylation-dependent transcriptional silencing

Phenotypes:
1 GenomeRNAi human phenotype for DRAM1:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DRAM1

miRNA Products:		miRTarBase miRNAs that target DRAM1: hsa-mir-124 (MIRT004906)

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		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate DRAM1 (see all 21):
		hsa-miR-136 hsa-miR-496 hsa-miR-1297 hsa-miR-124 hsa-miR-199b-5p hsa-miR-29a* hsa-miR-506 hsa-miR-28-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DRAM1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DRAM1

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006914	autophagy	IEA	--
GO:0006915	apoptotic process	IEA	--

DRAM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DRAM1
Search CenterWatch for drugs/clinical trials and news about DRAM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for DRAM1 gene:

NM_018370.2

Unigene Cluster for DRAM1:

DNA-damage regulated autophagy modulator 1

Hs.525634 [show with all ESTs]

Unigene Representative Sequence: NM_018370

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000258534(uc001tix.3 uc010svv.2) ENST00000544152 ENST00000551403

ENST00000549365 ENST00000549066 ENST00000546729

miRNA Products:		OriGene 3'-UTR Clone: DRAM1 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-136 hsa-miR-496 hsa-miR-1297 hsa-miR-124 hsa-miR-199b-5p hsa-miR-29a* hsa-miR-506 hsa-miR-28-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DRAM1 3' UTR sequence

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Additional cDNA sequence:

AK002121.1 AK094923.1 AK297785.1 BC013773.1 BC018435.1

9 DOTS entries:

DT.213396 DT.86835766 DT.95353736 DT.99929399 DT.121152169 DT.121152337 DT.99938311 DT.100750270

DT.100750272

24/145 AceView cDNA sequences (see all 145):

BG250630 AU157697 AI304821 CA419796 BM763554 AA457689 CA421413 AI148797

BM562526 AW449733 BQ671657 BP352620 BE856855 BC018435 AW779136 BQ669342

BP344183 CA307951 CB141637 BM915337 BM915334 BM991570 BQ641768 AI927792

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for DRAM1 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7
SP1:
SP2:									-

ECgene alternative splicing isoforms for DRAM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DRAM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

DRAM1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Heart

Atrioventricular Canal

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Nkx2-1 GFP+ cells (Efficient derivation...)

Extraembryonic endoderm-like cells (Generation of extrae...)

See DRAM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DRAM1

SOURCE GeneReport for Unigene cluster: Hs.525634

SABiosciences Expression via Pathway-Focused PCR Array including DRAM1:

Autophagy in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DRAM1 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DRAM1¹	DNA-damage regulated autophagy modulator 1	72.57(n) 71.31(a)		418095 XM_001234898.2 XP_001234899.2
lizard (Anolis carolinensis)	Reptilia	DRAM1⁶	--	65(a)	1 ↔ 1	5(17463545-17473297)
zebrafish (Danio rerio)	Actinopterygii	dram1¹	DNA-damage regulated autophagy modulator 1	55.27(n) 47.86(a)		450028 NM_001006049.1 NP_001006049.1

ENSEMBL Gene Tree for DRAM1 (if available)
TreeFam Gene Tree for DRAM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DRAM1 gene

DRAM2² TMEM150A² TMEM150C² TMEM150B²

1 SIMAP similar gene for DRAM1 using alignment to 4 protein entries: DRAM1_HUMAN (see all proteins):

DRAM2

DRAM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76585568^1,2	C,F	--	102269314(+)	`TTGTAT/GGGCGG`	1	--	us2k¹		1		EA	120
rs11111066^1,2	C,A	--	102269318(+)	`ATGGCG/AGGCAC`	1	--	us2k¹		4		NA EA	244
rs140717593^1,2		--	102269333(+)	`TCCACA/GGCCAC`	1	--	us2k¹		0	--	--	--	--
rs189864786^1,2		--	102269511(+)	`TGTGTA/GTGCAT`	1	--	us2k¹		0	--	--	--	--
rs150835870^1,2	C	--	102269524(+)	`CCTCC-/AGTTGT`	1	--	us2k¹		0	--	--	--	--
rs10860804^1,2	C,F,A,H	--	102269821(+)	`CTCCAT/CTTCCC`	1	--	us2k¹		3		WA NA EA	358
rs536175^1,2		--	102269879(+)	`caggcA/Gtgagc`	1	--	us2k¹		0	--	--	--	--
rs145359966^1,2		--	102269903(+)	`TAATTA/TTTTGT`	1	--	us2k¹		0	--	--	--	--
rs79930553^1,2	C	--	102269980(+)	`TCCACC/TCACCT`	1	--	us2k¹		0	--	--	--	--
rs11111067^1,2	C,F	--	102270020(+)	`ATGAGC/ACACCA`	1	--	us2k¹		3		NA CSA	6

HapMap Linkage Disequilibrium report for DRAM1 (102271105 - 102405908 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DRAM1
1 CNV: 101607
2 Indels: 41268 39928

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DRAM1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DRAM1 for disorders           About GeneDecksing

OMIM gene information: 610776    OMIM disorders: --

1 disease for DRAM1:    About MalaCards

sarcoma

Export disorders for DRAM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DRAM1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DRAM1)

Utopia: connect your pdf to the dynamic
world of online information

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. (PubMed id 16839881)^{1, 2, 3} Crighton D.... Ryan K.M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Inhibition of damage-regulated autophagy modulator-1 ( DRAM-1) impairs neutrophil differentiation of NB4 APL cells. (PubMed id 22981223)¹ Humbert M....Tschan M.P. (2012)
DRAM-1 encodes multiple isoforms that regulate autopha gy. (PubMed id 22082963)¹ Mah L.Y....Ryan K.M. (2012)
Downregulation of VRK1 by p53 in response to DNA dama ge is mediated by the autophagic pathway. (PubMed id 21386980)¹ Valbuena A....Lazo P.A. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-trea ted Ewing sarcoma cells. (PubMed id 19706754)¹ Lorin S....Djavaheri-Mergny M. (2009)
Analysis of DRAM-related proteins reveals evolutionar ily conserved and divergent roles in the control of autophagy. (PubMed id 19556885)¹ O'Prey J....Ryan K.M. (2009)
The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins. (PubMed id 17397945)¹ Kerley-Hamilton J.S....Spinella M.J. (2007)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55332	HGNC: 25645	AceView: FLJ11259	Ensembl:ENSG00000136048	euGenes: HUgn55332
ECgene: DRAM1	H-InvDB: DRAM1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DRAM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DRAM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DRAM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DRAM1 gene:
Search GeneIP for patents involving DRAM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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	OriGene Antibodies for DRAM1		OriGene shRNA RFP for DRAM1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DRAM1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DRAM1
	OriGene Protein Over-expression Lysate for DRAM1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DRAM1		OriGene 3'-UTR Clone for DRAM1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DRAM1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DRAM1
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DRAM1		OriGene Custom Protein Services for DRAM1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DRAM1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DRAM1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DRAM1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DRAM1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DRAM1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DRAM1

	GenScript Custom Purified and Recombinant Proteins Services for DRAM1		GenScript cDNA clones with any tag delivered in your preferred vector for DRAM1
	GenScript Custom Assay Services for DRAM1		GenScript Custom Superior Antibodies Services for DRAM1
	GenScript Custom overexpressing Cell Line Services for DRAM1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Novus Tissue Slides
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM1

	SwitchGear 3'UTR luciferase reporter plasmids for DRAM1
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ThermoFisher Antibodies for DRAM1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRAM1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DRAM1

Sirion Biotech Customized:

	stable knockdown cell line services for DRAM1
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	design and validation of potent shRNA sequences against DRAM1
	adenovirus for potent knockdown of DRAM1
	adenovirus for overexpression of DRAM1
	stable overexpressing cell line services for DRAM1
	inducible overexpressing cell line services for DRAM1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DRAM1 gene at Home site.

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DRAM1 Gene

DNA-damage regulated autophagy modulator 1

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DRAM1 Gene

DNA-damage regulated autophagy modulator 1

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for DRAM1 gene

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for DRAM1 gene

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for DRAM1 gene

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for DRAM1 gene

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for DRAM1 gene

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for DRAM1 gene

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for DRAM1 gene

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for DRAM1 gene

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