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Aliases for DRAM1 Gene

Aliases for DRAM1 Gene

  • DNA Damage Regulated Autophagy Modulator 1 2 3 5
  • Damage-Regulated Autophagy Modulator 2 3 4
  • DRAM 3 4
  • DNA Damage-Regulated Autophagy Modulator Protein 1 3
  • DNA-Damage Regulated Autophagy Modulator 1 2

External Ids for DRAM1 Gene

Previous GeneCards Identifiers for DRAM1 Gene

  • GC12P100798
  • GC12P102271
  • GC12P099330

Summaries for DRAM1 Gene

Entrez Gene Summary for DRAM1 Gene

  • This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRAM1 Gene

DRAM1 (DNA Damage Regulated Autophagy Modulator 1) is a Protein Coding gene. Among its related pathways are p53 Pathway (RnD). An important paralog of this gene is DRAM2.

UniProtKB/Swiss-Prot for DRAM1 Gene

  • Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAM1 Gene

Genomics for DRAM1 Gene

Regulatory Elements for DRAM1 Gene

Enhancers for DRAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G101888 1.6 FANTOM5 Ensembl ENCODE 28.2 +14.0 14021 5.1 HDGF FOXA2 ATF1 MLX ARID4B FEZF1 ZNF48 FOS SP5 MXD4 DRAM1 GNPTAB CHPT1 RNA5SP369 RNU6-101P PIR46358
GH12G101875 1.5 FANTOM5 ENCODE 27 +0.0 21 4.5 HDGF HNRNPUL1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF207 ZNF143 DRAM1 ENSG00000257222 CHPT1 ST13P22 UTP20 NUP37 GNPTAB PIR46358
GH12G101858 1.5 FANTOM5 Ensembl ENCODE 23.6 -17.2 -17241 2.3 TBP TBL1XR1 WRNIP1 BMI1 EBF1 RELA EED RELB IKZF2 CREM DRAM1 CHPT1 GNPTAB RNU6-1183P RNA5SP369
GH12G101854 1.6 FANTOM5 Ensembl ENCODE 17.5 -21.1 -21140 4.0 PKNOX1 ARNT FEZF1 TCF12 ZNF766 ELK1 GATA2 FOS JUNB NCOA1 DRAM1 CHPT1 GNPTAB RNA5SP369 RNU6-1183P
GH12G101865 1.2 FANTOM5 ENCODE 15 -11.2 -11202 0.7 HDAC1 ETV1 SIN3A ZBTB40 FOSL1 ZNF316 GATA2 CBX5 NFE2 TRIM24 DRAM1 RNU6-1183P RNA5SP369
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DRAM1 on UCSC Golden Path with GeneCards custom track

Promoters for DRAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056328 473 2401 HDGF HNRNPUL1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF207 ZNF143

Genomic Location for DRAM1 Gene

Chromosome:
12
Start:
101,877,327 bp from pter
End:
102,012,130 bp from pter
Size:
134,804 bases
Orientation:
Plus strand

Genomic View for DRAM1 Gene

Genes around DRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRAM1 Gene

Proteins for DRAM1 Gene

  • Protein details for DRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N682-DRAM1_HUMAN
    Recommended name:
    DNA damage-regulated autophagy modulator protein 1
    Protein Accession:
    Q8N682
    Secondary Accessions:
    • B7Z4T0
    • Q7L3E3
    • Q9NUN1

    Protein attributes for DRAM1 Gene

    Size:
    238 amino acids
    Molecular mass:
    26253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92091.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRAM1 Gene

Post-translational modifications for DRAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DRAM1 Gene

Domains & Families for DRAM1 Gene

Protein Domains for DRAM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N682

UniProtKB/Swiss-Prot:

DRAM1_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with DRAM1: view

No data available for Gene Families for DRAM1 Gene

Function for DRAM1 Gene

Molecular function for DRAM1 Gene

UniProtKB/Swiss-Prot Function:
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
UniProtKB/Swiss-Prot Induction:
By p53/TP53 and p73/TP73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.

Gene Ontology (GO) - Molecular Function for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DRAM1: view
genes like me logo Genes that share phenotypes with DRAM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DRAM1 Gene

Localization for DRAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAM1 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRAM1 gene
Compartment Confidence
lysosome 5
plasma membrane 3
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19895784
GO:0005764 lysosome IEA,IDA 19895784
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DRAM1: view

Pathways & Interactions for DRAM1 Gene

SuperPathways for DRAM1 Gene

SuperPathway Contained pathways
1 p53 Pathway (RnD)
genes like me logo Genes that share pathways with DRAM1: view

Pathways by source for DRAM1 Gene

1 R&D Systems pathway for DRAM1 Gene

Interacting Proteins for DRAM1 Gene

Gene Ontology (GO) - Biological Process for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0010506 regulation of autophagy IDA 19895784
genes like me logo Genes that share ontologies with DRAM1: view

No data available for SIGNOR curated interactions for DRAM1 Gene

Drugs & Compounds for DRAM1 Gene

No Compound Related Data Available

Transcripts for DRAM1 Gene

Unigene Clusters for DRAM1 Gene

DNA-damage regulated autophagy modulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRAM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for DRAM1 Gene

GeneLoc Exon Structure for
DRAM1
ECgene alternative splicing isoforms for
DRAM1

Expression for DRAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRAM1 Gene

mRNA differential expression in normal tissues according to GTEx for DRAM1 Gene

This gene is overexpressed in Lung (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of DRAM1 Gene:

DRAM1

SOURCE GeneReport for Unigene cluster for DRAM1 Gene:

Hs.525634

Evidence on tissue expression from TISSUES for DRAM1 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with DRAM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRAM1 Gene

Orthologs for DRAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRAM1 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia FLJ11259 35
  • 96 (a)
OneToOne
DRAM1 34
  • 89.92 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DRAM1 34 35
  • 88.8 (n)
mouse
(Mus musculus)
Mammalia Dram1 34 16 35
  • 88.47 (n)
rat
(Rattus norvegicus)
Mammalia Dram1 34
  • 86.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves DRAM1 34 35
  • 72.57 (n)
lizard
(Anolis carolinensis)
Reptilia DRAM1 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dram1 34
  • 65.52 (n)
zebrafish
(Danio rerio)
Actinopterygii dram1 34 35
  • 55.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4025 34 35
  • 49.44 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000808 34
  • 49.27 (n)
worm
(Caenorhabditis elegans)
Secernentea C33A11.2 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6942 35
  • 14 (a)
OneToOne
Species where no ortholog for DRAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRAM1 Gene

ENSEMBL:
Gene Tree for DRAM1 (if available)
TreeFam:
Gene Tree for DRAM1 (if available)

Paralogs for DRAM1 Gene

Paralogs for DRAM1 Gene

(1) SIMAP similar genes for DRAM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DRAM1: view

Variants for DRAM1 Gene

Sequence variations from dbSNP and Humsavar for DRAM1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000045636 -- 101,904,761(+) ACTAT(-/TC)TCTCT intron-variant
rs1000085992 -- 101,912,326(+) ATGAA(A/G)CTTTC intron-variant
rs1000138272 -- 101,918,200(+) TTTAT(A/G)TGCAG intron-variant
rs1000188374 -- 101,895,714(+) TACCG(A/G)CGTCT intron-variant
rs1000283280 -- 101,895,851(+) AGGTG(C/T)GAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRAM1 Gene

Variant ID Type Subtype PubMed ID
dgv308e199 CNV deletion 23128226
dgv88e215 CNV deletion 23714750
esv2318192 CNV deletion 18987734
esv2499618 CNV deletion 19546169
esv2665303 CNV deletion 23128226
esv2746281 CNV deletion 23290073
esv2746282 CNV deletion 23290073
esv2746283 CNV deletion 23290073
esv3361767 CNV insertion 20981092
esv3394643 CNV insertion 20981092
esv3450382 CNV insertion 20981092
esv3630581 CNV loss 21293372
esv3630582 CNV loss 21293372
esv3892258 CNV gain 25118596
esv4264 CNV loss 18987735
nsv1053046 CNV gain 25217958
nsv1125557 CNV tandem duplication 24896259
nsv560030 CNV gain 21841781
nsv560031 CNV gain 21841781
nsv983359 CNV duplication 23825009

Variation tolerance for DRAM1 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DRAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAM1 Gene

Disorders for DRAM1 Gene

Relevant External Links for DRAM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DRAM1

No disorders were found for DRAM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRAM1 Gene

Publications for DRAM1 Gene

  1. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. (PMID: 16839881) Crighton D. … Ryan K.M. (Cell 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. (PMID: 25633293) Guan J.J. … Qin Z.H. (Cell Death Dis 2015) 3 64
  4. The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to authophagic defense. (PMID: 24922577) van der Vaart M. … Meijer A.H. (Cell Host Microbe 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for DRAM1 Gene

Sources for DRAM1 Gene

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