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Aliases for DRAM1 Gene

Aliases for DRAM1 Gene

  • DNA-Damage Regulated Autophagy Modulator 1 2 3
  • Damage-Regulated Autophagy Modulator 2 3 4
  • DRAM 3 4
  • DNA Damage-Regulated Autophagy Modulator Protein 1 3

External Ids for DRAM1 Gene

Summaries for DRAM1 Gene

Entrez Gene Summary for DRAM1 Gene

  • This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRAM1 Gene

DRAM1 (DNA-Damage Regulated Autophagy Modulator 1) is a Protein Coding gene. An important paralog of this gene is DRAM2.

UniProtKB/Swiss-Prot for DRAM1 Gene

  • Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAM1 Gene

Genomics for DRAM1 Gene

Genomic Location for DRAM1 Gene

Start:
101,877,327 bp from pter
End:
102,012,130 bp from pter
Size:
134,804 bases
Orientation:
Plus strand

Genomic View for DRAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRAM1 Gene

No data available for Regulatory Elements for DRAM1 Gene

Proteins for DRAM1 Gene

  • Protein details for DRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N682-DRAM1_HUMAN
    Recommended name:
    DNA damage-regulated autophagy modulator protein 1
    Protein Accession:
    Q8N682
    Secondary Accessions:
    • B7Z4T0
    • Q7L3E3
    • Q9NUN1

    Protein attributes for DRAM1 Gene

    Size:
    238 amino acids
    Molecular mass:
    26253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92091.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRAM1 Gene

Proteomics data for DRAM1 Gene at MOPED

Post-translational modifications for DRAM1 Gene

No Post-translational modifications

Other Protein References for DRAM1 Gene

No data available for DME Specific Peptides for DRAM1 Gene

Domains for DRAM1 Gene

Protein Domains for DRAM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N682

UniProtKB/Swiss-Prot:

DRAM1_HUMAN
Family:
  • Belongs to the DRAM/TMEM150 family.:
    • Q8N682
genes like me logo Genes that share domains with DRAM1: view

No data available for Gene Families for DRAM1 Gene

Function for DRAM1 Gene

Molecular function for DRAM1 Gene

UniProtKB/Swiss-Prot Function: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
UniProtKB/Swiss-Prot Induction: By p53/TP53 and p73/TP73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.

Gene Ontology (GO) - Molecular Function for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DRAM1: view

Phenotypes for DRAM1 Gene

GenomeRNAi human phenotypes for DRAM1:
genes like me logo Genes that share phenotypes with DRAM1: view

miRNA for DRAM1 Gene

miRTarBase miRNAs that target DRAM1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DRAM1 Gene

Localization for DRAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAM1 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DRAM1 Gene COMPARTMENTS Subcellular localization image for DRAM1 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19895784
GO:0005764 lysosome IDA 19895784
GO:0005765 lysosomal membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DRAM1: view

Pathways for DRAM1 Gene

SuperPathways for DRAM1 Gene

No Data Available

Interacting Proteins for DRAM1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258534%0d%0a9606.ENSP00000235307%0d%0a
Selected Interacting proteins: ENSP00000258534 Q8N682-DRAM1_HUMAN for DRAM1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0010506 regulation of autophagy IDA 19895784
genes like me logo Genes that share ontologies with DRAM1: view

No data available for Pathways by source for DRAM1 Gene

Transcripts for DRAM1 Gene

Unigene Clusters for DRAM1 Gene

DNA-damage regulated autophagy modulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DRAM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for DRAM1 Gene

GeneLoc Exon Structure for
DRAM1
ECgene alternative splicing isoforms for
DRAM1

Expression for DRAM1 Gene

mRNA expression in normal human tissues for DRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRAM1 Gene

This gene is overexpressed in Lung (4.7).

SOURCE GeneReport for Unigene cluster for DRAM1 Gene Hs.525634

genes like me logo Genes that share expressions with DRAM1: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for DRAM1 Gene

Orthologs for DRAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRAM1 35
  • 99.72 (n)
  • 100 (a)
DRAM1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DRAM1 35
  • 89.92 (n)
  • 95.8 (a)
FLJ11259 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRAM1 35
  • 88.8 (n)
  • 93.7 (a)
DRAM1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dram1 35
  • 88.47 (n)
  • 94.94 (a)
Dram1 16
Dram1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dram1 35
  • 86.92 (n)
  • 94.94 (a)
chicken
(Gallus gallus)
Aves DRAM1 35
  • 72.57 (n)
  • 71.31 (a)
DRAM1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRAM1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dram1 35
  • 65.52 (n)
  • 63.52 (a)
zebrafish
(Danio rerio)
Actinopterygii dram1 35
  • 55.32 (n)
  • 47.66 (a)
dram1 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000808 35
  • 49.27 (n)
  • 39.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4025 35
  • 49.44 (n)
  • 38.16 (a)
CG4025 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33A11.2 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6942 36
  • 14 (a)
OneToOne
Species with no ortholog for DRAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRAM1 Gene

ENSEMBL:
Gene Tree for DRAM1 (if available)
TreeFam:
Gene Tree for DRAM1 (if available)

Paralogs for DRAM1 Gene

Paralogs for DRAM1 Gene

Selected SIMAP similar genes for DRAM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DRAM1: view

Variants for DRAM1 Gene

Sequence variations from dbSNP and Humsavar for DRAM1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7885 -- 101,923,454(+) GAGTG(A/C)CTCCT utr-variant-3-prime
rs10823 -- 101,923,363(-) GATGT(A/G)AAAAT utr-variant-3-prime
rs536175 -- 101,876,101(+) caggc(A/G)tgagc upstream-variant-2KB
rs756534 -- 101,886,477(+) ATTGG(G/T)CTGGA intron-variant
rs1140767 -- 101,913,638(-) acctc(C/T)acctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DRAM1 Gene

Variant ID Type Subtype PubMed ID
esv2665303 CNV Deletion 23128226
esv2746281 CNV Deletion 23290073
dgv308e199 CNV Deletion 23128226
esv2499618 CNV Deletion 19546169
esv2746282 CNV Deletion 23290073
esv2318192 CNV Deletion 18987734
esv4264 CNV Deletion 18987735
esv2746283 CNV Deletion 23290073
nsv899472 CNV Gain 21882294

Relevant External Links for DRAM1 Gene

HapMap Linkage Disequilibrium report
DRAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAM1 Gene

Disorders for DRAM1 Gene

No disorders were found for DRAM1 Gene.

No data available for UniProtKB/Swiss-Prot for DRAM1 Gene

Publications for DRAM1 Gene

  1. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. (PMID: 16839881) Crighton D. … Ryan K.M. (Cell 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. p53 and metabolism: Inside the TIGAR. (PMID: 16839873) Green D.R. … Chipuk J.E. (Cell 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DRAM1 Gene

Sources for DRAM1 Gene

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