Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DRAM1 Gene

protein-coding   GIFtS: 45
GCID: GC12P102271

DNA-Damage Regulated Autophagy Modulator 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DNA-Damage Regulated Autophagy Modulator 11 2
Damage-Regulated Autophagy Modulator1 2 3
DRAM2 3
DNA Damage-Regulated Autophagy Modulator Protein 12

External Ids:    HGNC: 256451   Entrez Gene: 553322   Ensembl: ENSG000001360487   OMIM: 6107765   UniProtKB: Q8N6823   

Export aliases for DRAM1 gene to outside databases

Previous GC identifers: GC12P100798 GC12P099330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DRAM1 Gene:
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein
that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene
is associated with various tumors. This gene has a pseudogene on chromosome 4. (provided by RefSeq, Jul 2008)

GeneCards Summary for DRAM1 Gene:
DRAM1 (DNA-damage regulated autophagy modulator 1) is a protein-coding gene. Diseases associated with DRAM1 include tonsillitis, and sarcoma. An important paralog of this gene is DRAM2.

UniProtKB/Swiss-Prot: DRAM1_HUMAN, Q8N682
Function: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved
in p73/TP73-mediated autophagy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DRAM1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDRAM1 promoter sequence
   Search Chromatin IP Primers for DRAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.2

DRAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DRAM1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P102271:  view genomic region     (about GC identifiers)

Start:
102,271,105 bp from pter      End:
102,405,908 bp from pter
Size:
134,804 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DRAM1_HUMAN, Q8N682 (See protein sequence)
Recommended Name: DNA damage-regulated autophagy modulator protein 1  
Size: 238 amino acids; 26253 Da
Sequence caution: Sequence=BAA92091.1; Type=Erroneous initiation;
Secondary accessions: Q7L3E3 Q9NUN1

Explore the universe of human proteins at neXtProt for DRAM1: NX_Q8N682

Explore proteomics data for DRAM1 at MOPED


See DRAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060840.2  
ENSEMBL proteins: 
 ENSP00000258534   ENSP00000445827   ENSP00000448075   ENSP00000447171   ENSP00000447906  

DRAM1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for DRAM1
OriGene Custom MassSpec
OriGene Custom Protein Services for DRAM1
GenScript Custom Purified and Recombinant Proteins Services for DRAM1
Novus Biologicals DRAM1 Proteins
Novus Biologicals DRAM1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for DRAM1

DRAM1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of DRAM1
Browse R&D Systems for Antibodies
OriGene Antibodies for DRAM1
OriGene Custom Antibody Services for DRAM1
Novus Biologicals DRAM1 Antibodies
Search for Antibodies for DRAM1 at Abcam
Cloud-Clone Corp. Antibodies for DRAM1
ThermoFisher Antibodies for DRAM1
LSBio Antibodies in human, mouse, rat for DRAM1

DRAM1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DRAM1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DRAM1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DRAM1
Cloud-Clone Corp. CLIAs for DRAM1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
2 InterPro protein domains:
 IPR019402 Frag1/DRAM/Sfk1
 IPR027315 DRAM/TMEM150

Graphical View of Domain Structure for InterPro Entry Q8N682

ProtoNet protein and cluster: Q8N682

UniProtKB/Swiss-Prot: DRAM1_HUMAN, Q8N682
Similarity: Belongs to the DRAM/TMEM150 family


DRAM1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DRAM1_HUMAN, Q8N682
Function: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved
in p73/TP73-mediated autophagy
Induction: By p53/TP53 and p73/TP73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell
lines by methylation-dependent transcriptional silencing

Phenotypes:
     1 GenomeRNAi human phenotype for DRAM1:

 Synthetic lethal with Ras 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRAM1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DRAM1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DRAM1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DRAM1

miRNA
Products:
    
miRTarBase miRNAs that target DRAM1:
hsa-mir-124-3p (MIRT004906)

Block miRNA regulation of human, mouse, rat DRAM1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DRAM1 (see all 21):
hsa-miR-136 hsa-miR-496 hsa-miR-1297 hsa-miR-124 hsa-miR-199b-5p hsa-miR-29a* hsa-miR-506 hsa-miR-28-5p
SwitchGear 3'UTR luciferase reporter plasmidDRAM1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DRAM1
Predesigned siRNA for gene silencing in human, mouse, rat DRAM1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DRAM1

Clone
Products:
     
OriGene clones in human, mouse for DRAM1 (see all 7)
OriGene ORF clones in mouse, rat for DRAM1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DRAM1 (NM_018370)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRAM1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRAM1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DRAM1
Browse ESI BIO Cell Lines and PureStem Progenitors for DRAM1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
DRAM1_HUMAN, Q8N682: Lysosome membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
lysosome5
vacuole5
plasma membrane3

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA19895784
GO:0005764lysosome IDA19895784
GO:0005765lysosomal membrane IEA--
GO:0016021integral component of membrane IEA--

DRAM1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Pathway & Disease-focused RT2 Profiler PCR Array including DRAM1: 
          Autophagy in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for DRAM1

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006914autophagy IEA--
GO:0030262apoptotic nuclear changes IDA19895784
GO:0097194execution phase of apoptosis IC19895784

DRAM1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DRAM1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DRAM1 gene: 
NM_018370.2  

Unigene Cluster for DRAM1:

DNA-damage regulated autophagy modulator 1
Hs.525634  [show with all ESTs]
Unigene Representative Sequence: NM_018370
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000258534(uc001tix.3 uc010svv.2) ENST00000544152 ENST00000551403
ENST00000549365 ENST00000549066 ENST00000546729
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DRAM1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DRAM1 (see all 21):
hsa-miR-136 hsa-miR-496 hsa-miR-1297 hsa-miR-124 hsa-miR-199b-5p hsa-miR-29a* hsa-miR-506 hsa-miR-28-5p
SwitchGear 3'UTR luciferase reporter plasmidDRAM1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DRAM1
Predesigned siRNA for gene silencing in human, mouse, rat DRAM1
Clone
Products:
     
OriGene clones in human, mouse for DRAM1 (see all 7)
OriGene ORF clones in mouse, rat for DRAM1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DRAM1 (NM_018370)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DRAM1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRAM1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DRAM1
OriGene qSTAR qPCR primer pairs in human, mouse for DRAM1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRAM1
  QuantiTect SYBR Green Assays in human, mouse, rat DRAM1
  QuantiFast Probe-based Assays in human, mouse, rat DRAM1

Additional mRNA sequence: 

AK002121.1 AK094923.1 AK297785.1 BC013773.1 BC018435.1 

9 DOTS entries:

DT.213396  DT.86835766  DT.95353736  DT.99929399  DT.121152169  DT.121152337  DT.99938311  DT.100750270 
DT.100750272 

Selected AceView cDNA sequences (see all 145):

BM763001 BQ669342 BG286492 BQ670579 BM556097 BM912860 BU628718 BP344183 
BQ641768 AI927792 AW206783 BM991570 AW779136 BM915334 BM915337 CB141637 
CA307951 BC018435 CA419796 BM763554 AW449733 BQ671657 BE856855 BP352620 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for DRAM1    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:                                                
SP2:                          -                     


ECgene alternative splicing isoforms for DRAM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DRAM1 expression in normal human tissues (normalized intensities)      DRAM1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DRAM1 Expression
About this image


DRAM1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)    fully expand to see all 3 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Bone (Muscoskeletal System)
         Bone Marrow
DRAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DRAM1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.525634
    Pathway & Disease-focused RT2 Profiler PCR Array including DRAM1: 
          Autophagy in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for DRAM1
OriGene qSTAR qPCR primer pairs in human, mouse for DRAM1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRAM1
QuantiTect SYBR Green Assays in human, mouse, rat DRAM1
QuantiFast Probe-based Assays in human, mouse, rat DRAM1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for DRAM1 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dram11 , 5 DNA-damage regulated autophagy modulator 11, 5 88.47(n)1
94.94(a)1
  10 (43.81 cM)5
717121  NM_027878.21  NP_082154.21 
 883228045 
chicken
(Gallus gallus)
Aves DRAM11 DNA-damage regulated autophagy modulator 1 72.57(n)
71.31(a)
  418095  XM_001234898.3  XP_001234899.2 
lizard
(Anolis carolinensis)
Reptilia DRAM16
DNA-damage regulated autophagy modulator 1
59(a)
1 ↔ 1
5(17451623-17474170)
tropical clawed frog
(Xenopus tropicalis)
Amphibia dram11 DNA-damage regulated autophagy modulator 1 65.52(n)
63.52(a)
  548586  NM_001015869.1  NP_001015869.1 
zebrafish
(Danio rerio)
Actinopterygii dram11 DNA-damage regulated autophagy modulator 1 55.32(n)
47.66(a)
  450028  NM_001006049.1  NP_001006049.1 
fruit fly
(Drosophila melanogaster)
Insecta CG40251 CG4025 49.44(n)
38.16(a)
  31177  NM_130623.3  NP_569979.1 
worm
(Caenorhabditis elegans)
Secernentea C33A11.26
Protein C33A11.2 (C33A11.2) mRNA, complete cds
21(a)
1 → many
X(15365994-15370000) WBGene00007878


ENSEMBL Gene Tree for DRAM1 (if available)
TreeFam Gene Tree for DRAM1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for DRAM1 gene
DRAM22  
1 SIMAP similar gene for DRAM1 using alignment to 4 protein entries:     DRAM1_HUMAN (see all proteins):
DRAM2

DRAM1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for DRAM1 (see all 1265)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs562781831,2
C--99336367(+) TTTTT-/T/TT  
        
GAAAT
1 -- int12NA 4
rs765855681,2
C,F--102269314(+) TTGTAT/GGGCGG 1 -- us2k11Minor allele frequency- G:0.19EA 120
rs111110661,2
C,A--102269318(+) ATGGCG/AGGCAC 1 -- us2k14Minor allele frequency- A:0.12NA EA 244
rs1407175931,2
--102269333(+) TCCACA/GGCCAC 1 -- us2k10--------
rs1898647861,2
--102269511(+) TGTGTA/GTGCAT 1 -- us2k10--------
rs1508358701,2
C--102269524(+) CCTCC-/AGTTGT 1 -- us2k10--------
rs108608041,2
C,F,A,H--102269821(+) CTCCAT/CTTCCC 1 -- us2k13Minor allele frequency- C:0.28WA NA EA 358
rs5361751,2
--102269879(+) caggcA/Gtgagc 1 -- us2k10--------
rs1453599661,2
--102269903(+) TAATTA/TTTTGT 1 -- us2k10--------
rs799305531,2
C--102269980(+) TCCACC/TCACCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for DRAM1 (102271105 - 102405908 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for DRAM1:    About this table    
Variant IDTypeSubtypePubMed ID
esv4264CNV Deletion18987735
esv2665303CNV Deletion23128226
esv2499618CNV Deletion19546169
esv2746283CNV Deletion23290073
dgv308e199CNV Deletion23128226
esv2318192CNV Deletion18987734
esv2746282CNV Deletion23290073
esv2746281CNV Deletion23290073
nsv899472CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DRAM1
DNA2.0 Custom Variant and Variant Library Synthesis for DRAM1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 610776    OMIM disorders: --

9 diseases for DRAM1:    About MalaCards
tonsillitis    sarcoma    systemic lupus erythematosus    lupus erythematosus
thyroiditis    cerebritis    endotheliitis    prostatitis
breast cancer


DRAM1 for disorders           About GeneDecksing


Export disorders for DRAM1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DRAM1 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with DRAM1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. (PubMed id 16839881)1, 2, 3 Crighton D.... Ryan K.M. (Cell 2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells. (PubMed id 23337876)1 Yi H....Liu X. (FEBS Lett. 2013)
  4. Reactive oxygen species-dependent down-regulation of tumor suppressor genes PTEN, USP28, DRAM, TIGAR, and CYLD under oxidative stress. (PubMed id 23832602)1 Kim S.J....Lim C.J. (Biochem. Genet. 2013)
  5. DRAM1 regulates autophagy flux through lysosomes. (PubMed id 23696801)1 Zhang X.D....Qin Z.H. (PLoS ONE 2013)
  6. The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. (PubMed id 22525272)1 Galavotti S....Salomoni P. (Oncogene 2013)
  7. DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV. (PubMed id 23658518)1 Laforge M....Estaquier J. (PLoS Pathog. 2013)
  8. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PubMed id 23273568)1 Yang W....Lau Y.L. (Am. J. Hum. Genet. 2013)
  9. Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells. (PubMed id 22981223)1 Humbert M....Tschan M.P. (Leuk. Res. 2012)
  10. DRAM-1 encodes multiple isoforms that regulate autophagy. (PubMed id 22082963)1 Mah L.Y....Ryan K.M. (Autophagy 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 55332 HGNC: 25645 AceView: FLJ11259 Ensembl:ENSG00000136048 euGenes: HUgn55332
ECgene: DRAM1 H-InvDB: DRAM1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DRAM1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DRAM1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DRAM1 gene:
Search GeneIP for patents involving DRAM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 Browse Kits and Assays available from EMD Millipore
 Browse Small Molecules at EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of DRAM1
 Browse Purified and Recombinant Proteins at EMD Millipore
 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for DRAM1   OriGene RNAi products in human, mouse, rat for DRAM1  
 OriGene qPCR primer pairs and template standards for DRAM1   OriGene Protein Over-expression Lysate for DRAM1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for DRAM1  
 OriGene qSTAR qPCR primer pairs in human, mouse for DRAM1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for DRAM1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DRAM1   OriGene Custom Protein Services for DRAM1  

 
 
 Block miRNA regulation of human, mouse, rat DRAM1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DRAM1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DRAM1 Predesigned siRNA for gene silencing in human, mouse, rat DRAM1
 QuantiFast Probe-based Assays in human, mouse, rat DRAM1 QuantiTect SYBR Green Assays in human, mouse, rat DRAM1
 PCR Arrays including human, mouse, rat DRAM1 Search Chromatin IP Primers for DRAM1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DRAM1  Search GeneGlobe Interaction Network for DRAM1
 Search Regulatory tfbs for DRAM1
 GenScript Custom Purified and Recombinant Proteins Services for DRAM1 GenScript cDNA clones with any tag delivered in your preferred vector for DRAM1
 GenScript Custom Assay Services for DRAM1 GenScript Custom overexpressing Cell Line Services for DRAM1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DRAM1
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DRAM1 antibodies
 DRAM1 proteins
 DRAM1 lysates
 Search for Antibodies for DRAM1 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for DRAM1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for DRAM1
 Antibodies for DRAM1
 ELISAs for DRAM1
 CLIAs for DRAM1



 Browse ESI BIO Cell Lines and PureStem Progenitors for DRAM1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DRAM1
 SwitchGear 3'UTR luciferase reporter plasmids for DRAM1
 SwitchGear Promoter luciferase reporter plasmids for DRAM1
 ThermoFisher Antibodies for DRAM1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DRAM1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DRAM1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DRAM1
 LSBio Antibodies in human, mouse, rat for DRAM1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DRAM1 gene at Home site.
Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4