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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DR1 Gene

protein-coding GIFtS: 56
GCID: GC01P093811

down-regulator of transcription 1, TBP-binding (negative...

Explore 6 diseases affiliated with
DR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Down-Regulator Of Transcription 1, TBP-Binding (Negative Cofactor 2)¹ ²		TATA-Binding Protein-Associated Phosphoprotein² ³
NC2¹ ²		Protein Dr1²
NC2-BETA¹ ²		NC2-Beta¹
Negative Cofactor 2-Beta² ³		Down-Regulator Of Transcription 1³

External Ids:	HGNC: 3017¹	Entrez Gene: 1810²	Ensembl: ENSG00000117505⁷	OMIM: 601482⁵	UniProtKB: Q01658³

Export aliases for DR1 gene to outside databases

Previous GC identifers: GC01P094217 GC01P093017 GC01P093162 GC01P093283 GC01P093256 GC01P093523 GC01P091933

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DR1:

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated

levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its

interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a

glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a

mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the

assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: NC2B_HUMAN, Q01658

Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated

and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent

complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the

ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4

Gene Wiki entry for DR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DR1 gene promoter:
TBP AP-1 TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DR1 promoter sequence

Search SABiosciences Chromatin IP Primers for DR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1 Ensembl cytogenetic band: 1p22.1 HGNC cytogenetic band: 1p22.1

DR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DR1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P093811: view genomic region (about GC identifiers)

Start:	93,811,445 bp from pter	End:	93,828,149 bp from pter
Size:	16,705 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NC2B_HUMAN, Q01658 (See protein sequence)

Recommended Name: Protein Dr1

Size: 176 amino acids; 19444 Da

Subunit: Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP

and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3.

Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2,

CCDC101 and DR1

Subcellular location: Nucleus

1 PDB 3D structure from and Proteopedia for DR1:

1JFI (3D)

Explore the universe of human proteins at neXtProt for DR1: NX_Q01658

Post-translational modifications:

Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01658

DR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001929.1

ENSEMBL proteins:

ENSP00000359295 ENSP00000359290

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for DR1
	Uscn Proteins for DR1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	IDA	18838386

DR1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR003957 Transcrpt_fac_CBFA/NFYB_topo

IPR027113 Dr1/Ncb2

IPR003958 CBFA_NFYB_domain

IPR009072 Histone-fold

Graphical View of Domain Structure for InterPro Entry Q01658

ProtoNet protein and cluster: Q01658

2 Blocks protein families:

IPB003957 CCAAT-binding transcription factor subunit A signature

IPB003958 Transcription factor CBF/NF-Y/archaeal histone

UniProtKB/Swiss-Prot: NC2B_HUMAN, Q01658

Similarity: Belongs to the NC2 beta/DR1 family

Similarity: Contains 1 histone-fold domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NC2B_HUMAN, Q01658

Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated

and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent

complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the

ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4

Genatlas biochemistry entry for DR1:

TATA binding (TBP) protein-associated phosphoprotein,(19kDa),expressed in Hela cells,inhibitor of class II and III

genes transcription

miRNA Products:		OriGene 3'-UTR Clone: DR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DR1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate DR1 (see all 23):
		hsa-miR-21* hsa-miR-4311 hsa-miR-137 hsa-miR-200a hsa-miR-340 hsa-miR-548a-3p hsa-miR-141 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: DR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DR1 (see all 7) OriGene shRNA RFP: DR1 OriGene siRNA: DR1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DR1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DR1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	8670811
GO:0003714	transcription corepressor activity	TAS	8670811
GO:0005515	protein binding	IPI	18838386
GO:0008134	transcription factor binding	TAS	1339312
GO:0017025	TBP-class protein binding	IDA	18838386

DR1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for DR1

Chromatin Regulation / Acetylation

DR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for DR1 (Q01658^{2, 3} ENSP00000359290⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POLE3	Q9NRF9²^,³, ENSP00000363284⁴	MINT-67751 I2D: score=5 STRING: ENSP00000363284
NFIL3	Q16649³, ENSP00000297689⁴	I2D: score=3 STRING: ENSP00000297689
NFYC	Q13952³, ENSP00000396620⁴	I2D: score=3 STRING: ENSP00000396620
TBP	P20226³, ENSP00000230354⁴	I2D: score=2 STRING: ENSP00000230354
CSRP2BP	Q9H8E8³, ENSP00000278816⁴	I2D: score=1 STRING: ENSP00000278816

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	8670811
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0043966	histone H3 acetylation	IDA	18838386

DR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DR1
Search CenterWatch for drugs/clinical trials and news about DR1 / NC2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DR1 gene:

NM_001938.2

Unigene Cluster for DR1:

Down-regulator of transcription 1, TBP-binding (negative cofactor 2)

Hs.348418 [show with all ESTs]

Unigene Representative Sequence: NM_001938

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370272(uc001dpu.3) ENST00000370267 ENST00000481583

miRNA Products:		OriGene 3'-UTR Clone: DR1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DR1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate DR1 (see all 23):
		hsa-miR-21* hsa-miR-4311 hsa-miR-137 hsa-miR-200a hsa-miR-340 hsa-miR-548a-3p hsa-miR-141 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: DR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DR1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DR1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): DR1 (NM_013993)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DR1
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DR1

Additional cDNA sequence:

AK057541.1 AK223442.1 AK311288.1 AL137673.1 AL833729.1 BC002809.2 BC035507.2 BC068553.1

BT006972.1 M97388.1

7 DOTS entries:

DT.91753483 DT.86854700 DT.97793415 DT.100796265 DT.95277853 DT.121451584 DT.95277859

24/230 AceView cDNA sequences (see all 230):

BX957166 BM699348 CR590361 NM_001938 AW516932 CB151248 BM977940 BM990042

BI825683 BC035507 BG610966 W74247 AI453362 AA287935 BI859129 AI753329

W79798 BM930741 BI518801 BM127445 CB215131 AI083576 AA831544 CK906084

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTGCATTT

About this image

DR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DR1

SOURCE GeneReport for Unigene cluster: Hs.348418

SABiosciences Expression via Pathway-Focused PCR Array including DR1:

Transcription Factors in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DR1 gene from 9/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DR1¹	down-regulator of transcription 1, TBP-binding (negative more	85.8(n) 98.86(a)		424496 NM_001008478.1 NP_001008478.1
lizard (Anolis carolinensis)	Reptilia	DR1⁶	--	94(a)	1 ↔ 1	4(88271556-88287069)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32418²	Xenopus laevis transcribed sequence with strong similarity more	80.14(n)		BJ632672.1
zebrafish (Danio rerio)	Actinopterygii	dr1¹	down-regulator of transcription 1	79.17(n) 93.75(a)		768171 NM_001077314.1 NP_001070782.1
fruit fly (Drosophila melanogaster)	Insecta	NC2&bgr;³ NC2beta¹	negative regulation of transcriptional pre-initiation more³ CG4185-PA¹	70(a)³ 56.92(n)¹ 61.4(a)¹		35B8³ 34875¹ NM_135892.3¹ NP_609736.1¹
worm (Caenorhabditis elegans)	Secernentea	dro-1¹	Protein DRO-1	53.67(n) 44.65(a)		191629 NM_067349.1 NP_499750.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NCB2(YDR397C)⁴ NCB2¹	Subunit of a heterodimeric NC2 transcription regulator more⁴ Ncb2p¹	50.26(n)¹ 40.62(a)¹		4(1266898-1266366)⁴ 852006^{1, 4} NP_010685.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	NF-YB12¹	nuclear factor Y, subunit B12	53.33(n) 44.83(a)		830715 NM_120902.2 NP_568190.1
rice (Oryza sativa)	Liliopsida	Os08g0383700¹	hypothetical protein	52.45(n) 44.06(a)		4345446 NM_001068233.1 NP_001061698.1

ENSEMBL Gene Tree for DR1 (if available)
TreeFam Gene Tree for DR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114846887^1,2	F,	--	93809510(+)	`AGGCTG/AGAGTG`	2	--	us2k¹ int¹		1		NA	120
rs142604154^1,2		--	93809620(+)	`CCACAA/CCCAGC`	2	--	us2k¹ int¹		0	--	--	--	--
rs182404647^1,2		--	93809634(+)	`TTTTTA/GTATTT`	2	--	int¹ us2k¹		0	--	--	--	--
rs145787940^1,2		--	93809680(+)	`TGGTCC/TCGAAC`	2	--	int¹ us2k¹		0	--	--	--	--
rs61266405^1,2	C,F,	--	93809710(+)	`GCCCCC/TCTTGG`	2	--	int¹ us2k¹		6		NA WA CSA EA	363
rs147764925^1,2		--	93809732(+)	`TGCTGA/GTATTA`	2	--	us2k¹ int¹		0	--	--	--	--
rs141262892^1,2		--	93809838(+)	`AAAAAC/GAAGTG`	2	--	int¹ us2k¹		0	--	--	--	--
rs186622990^1,2		--	93809841(+)	`AACAAC/GTGTCT`	2	--	us2k¹ int¹		0	--	--	--	--
rs114133914^1,2		--	93809961(+)	`AGAACA/GTTTTA`	2	--	int¹ us2k¹		0	--	--	--	--
rs75612756^1,2		--	93810086(+)	`AACATC/TCCACT`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DR1 (93811445 - 93828149 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DR1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DR1

DNA2.0 Custom Variant and Variant Library Synthesis for DR1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DR1 for disorders           About GeneDecksing

OMIM gene information: 601482    OMIM disorders: --

6 diseases for DR1:    About MalaCards

epidermolysis bullosa dystrophica epidermolysis bullosa stargardt disease hypoxia

neuroblastoma immunodeficiency

Human Genome Epidemiology (HuGE) Navigator: DR1 (28 documents)

Export disorders for DR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DR1 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with DR1)

Utopia: connect your pdf to the dynamic
world of online information

Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. (PubMed id 1339312)^{1, 2, 3, 9} Inostroza J.A.... Reinberg D. (1992)
A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. (PubMed id 8670811)^{1, 2, 9} Goppelt A.R.... Meisterernst M. (1996)
Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. (PubMed id 8836190)^{1, 2, 9} Cowell I.G. and Hurst H.C. (1996)
Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. (PubMed id 11461703)^{1, 2, 9} Kamada K.... Burley S.K. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genomic localization of the human gene encoding Dr1, a negative modulator of transcription of class II and class III genes. (PubMed id 9040789)^{1, 3} Purrello M....Sichel G. (1996)
Involvement of GTA protein NC2beta in neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation. (PubMed id 18538002)^{1, 9} Di Pietro C....Purrello M. (2008)
Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. (PubMed id 20230619)^{1, 9} Albert T.K....Meisterernst M. (2010)
Efficient binding of NC2.TATA-binding protein to DNA in the absence of TATA. (PubMed id 15574413)^{1, 9} Gilfillan S....Meisterernst M. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1810	HGNC: 3017	AceView: DR1	Ensembl:ENSG00000117505	euGenes: HUgn1810
ECgene: DR1	H-InvDB: DR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DR1	Pharmacogenomics, SNPs, Pathways

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Patent Information for DR1 gene:
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