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Aliases for DR1 Gene

Aliases for DR1 Gene

  • Down-Regulator Of Transcription 1 2 3 4 5
  • TATA-Binding Protein-Associated Phosphoprotein 3 4
  • Negative Cofactor 2-Beta 3 4
  • Negative Cofactor 2 2 3
  • NC2-BETA 3 4
  • Down-Regulator Of Transcription 1, TBP-Binding (Negative Cofactor 2) 2
  • Negative Cofactor 2 Beta 2
  • Protein Dr1 3
  • NC2B 3
  • NC2 3

External Ids for DR1 Gene

Previous GeneCards Identifiers for DR1 Gene

  • GC01P094217
  • GC01P093017
  • GC01P093162
  • GC01P093283
  • GC01P093256
  • GC01P093523
  • GC01P093811
  • GC01P091933

Summaries for DR1 Gene

Entrez Gene Summary for DR1 Gene

  • This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for DR1 Gene

DR1 (Down-Regulator Of Transcription 1) is a Protein Coding gene. Diseases associated with DR1 include Stargardt Disease and Metaphyseal Chondrodysplasia, Schmid Type. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. GO annotations related to this gene include sequence-specific DNA binding and transcription factor binding.

UniProtKB/Swiss-Prot for DR1 Gene

  • The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for DR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DR1 Gene

Genomics for DR1 Gene

Regulatory Elements for DR1 Gene

Enhancers for DR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F092803 1.2 FANTOM5 Ensembl ENCODE 23 -540.8 -540831 3.1 PKNOX1 ATF1 ARNT CREB3L1 GTF3C2 ZNF121 GATA2 FOS NFYC NCOA1 SNORD21 SNORA66 CCDC18-AS1 RPL5 DR1 RPAP2 EVI5 GC01M092807
GH01F093078 0.6 ENCODE 22.3 -265.5 -265453 4.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 CCDC18-AS1 SNORA66 SNORD21 RPL5 DNTTIP2 DR1 LOC100289500 ACTBP12 MTCO3P21 ENSG00000230439
GH01F093844 0.5 ENCODE 19.5 +500.7 500687 4.5 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 CCDC18-AS1 ENSG00000230439 DR1 DNTTIP2 TRR-TCT1-1 GCLM MIR760 GC01M093833
GH01F094232 1 FANTOM5 ENCODE 13.8 +890.8 890776 7.4 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF121 GLIS2 FOS ZNF202 CCDC18-AS1 LOC107985092 DR1 DNTTIP2 ABCA4 ENSG00000230439 ARHGAP29 ABCD3 GC01M094182
GH01F092791 1.4 Ensembl ENCODE 13.8 -553.6 -553564 1.0 HDGF HDAC1 ATF1 TBL1XR1 NFRKB FEZF1 CHAMP1 GATA2 ZNF366 SCRT2 SNORD21 SNORA66 RPL5 DR1 CCDC18-AS1 ENSG00000230439 FAM69A EVI5 CCNJP2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DR1 on UCSC Golden Path with GeneCards custom track

Promoters for DR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000540865 1612 5401 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for DR1 Gene

Chromosome:
1
Start:
93,345,888 bp from pter
End:
93,369,498 bp from pter
Size:
23,611 bases
Orientation:
Plus strand

Genomic View for DR1 Gene

Genes around DR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DR1 Gene

Proteins for DR1 Gene

  • Protein details for DR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01658-NC2B_HUMAN
    Recommended name:
    Protein Dr1
    Protein Accession:
    Q01658

    Protein attributes for DR1 Gene

    Size:
    176 amino acids
    Molecular mass:
    19444 Da
    Quaternary structure:
    • Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for DR1 Gene

neXtProt entry for DR1 Gene

Post-translational modifications for DR1 Gene

  • Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DR1 (DR1)

No data available for DME Specific Peptides for DR1 Gene

Domains & Families for DR1 Gene

Gene Families for DR1 Gene

Suggested Antigen Peptide Sequences for DR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01658

UniProtKB/Swiss-Prot:

NC2B_HUMAN :
  • Contains 1 histone-fold domain.
  • Belongs to the NC2 beta/DR1 family.
Domain:
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the NC2 beta/DR1 family.
genes like me logo Genes that share domains with DR1: view

Function for DR1 Gene

Molecular function for DR1 Gene

GENATLAS Biochemistry:
TATA binding (TBP) protein-associated phosphoprotein,(19kDa),expressed in Hela cells,inhibitor of class II and III genes transcription
UniProtKB/Swiss-Prot Function:
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for DR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0003714 transcription corepressor activity TAS 8670811
GO:0005515 protein binding IPI 18838386
GO:0008134 transcription factor binding TAS 1339312
GO:0017025 TBP-class protein binding IDA 18838386
genes like me logo Genes that share ontologies with DR1: view
genes like me logo Genes that share phenotypes with DR1: view

Animal Model Products

miRNA for DR1 Gene

miRTarBase miRNAs that target DR1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DR1 Gene

Localization for DR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DR1 Gene COMPARTMENTS Subcellular localization image for DR1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
genes like me logo Genes that share ontologies with DR1: view

Pathways & Interactions for DR1 Gene

genes like me logo Genes that share pathways with DR1: view

Pathways by source for DR1 Gene

1 Cell Signaling Technology pathway for DR1 Gene

Gene Ontology (GO) - Biological Process for DR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8670811
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with DR1: view

No data available for SIGNOR curated interactions for DR1 Gene

Transcripts for DR1 Gene

mRNA/cDNA for DR1 Gene

Unigene Clusters for DR1 Gene

Down-regulator of transcription 1, TBP-binding (negative cofactor 2):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DR1 Gene

No ASD Table

Relevant External Links for DR1 Gene

GeneLoc Exon Structure for
DR1
ECgene alternative splicing isoforms for
DR1

Expression for DR1 Gene

mRNA expression in normal human tissues for DR1 Gene

Protein differential expression in normal tissues from HIPED for DR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6) and Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DR1 Gene



Protein tissue co-expression partners for DR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DR1 Gene:

DR1

SOURCE GeneReport for Unigene cluster for DR1 Gene:

Hs.348418
genes like me logo Genes that share expression patterns with DR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DR1 Gene

Orthologs for DR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DR1 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia DR1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DR1 34 35
  • 94.89 (n)
dog
(Canis familiaris)
Mammalia DR1 34 35
  • 93.94 (n)
mouse
(Mus musculus)
Mammalia Dr1 34 16 35
  • 93.18 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910207 34
  • 92.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DR1 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DR1 34 35
  • 85.8 (n)
lizard
(Anolis carolinensis)
Reptilia DR1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dr1 34
  • 83.72 (n)
Str.1586 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32418 34
zebrafish
(Danio rerio)
Actinopterygii dr1 34 35
  • 79.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta NC2bgr 36
  • 70 (a)
NC2beta 34 35
  • 60.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010322 34
  • 63.18 (n)
worm
(Caenorhabditis elegans)
Secernentea dro-1 34 35
  • 54.2 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NCB2 34 35 37
  • 50.79 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06611g 34
  • 50.67 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR397C 34
  • 44.27 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NF-YB13 34
  • 58.13 (n)
rice
(Oryza sativa)
Liliopsida Os08g0383700 34
  • 55.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4043 35
  • 61 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC30D10.02 34
  • 56.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02017 34
  • 51.61 (n)
Species where no ortholog for DR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DR1 Gene

ENSEMBL:
Gene Tree for DR1 (if available)
TreeFam:
Gene Tree for DR1 (if available)

Paralogs for DR1 Gene

(2) SIMAP similar genes for DR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DR1: view

No data available for Paralogs for DR1 Gene

Variants for DR1 Gene

Sequence variations from dbSNP and Humsavar for DR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10541348 -- 93,362,827(+) ttttc(C/T)ttttt downstream-variant-500B
rs10621 -- 93,362,327(-) TCGTT(A/C)TAGAC utr-variant-3-prime
rs1062895 -- 93,346,019(+) GGCGG(A/C)AGCCA upstream-variant-2KB, utr-variant-5-prime
rs1062896 -- 93,346,024(+) CAGCC(A/G)CTGCG upstream-variant-2KB, utr-variant-5-prime
rs1062897 -- 93,346,032(+) GCGAC(A/T)CCCAC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DR1 Gene

Variant ID Type Subtype PubMed ID
nsv950208 CNV duplication 24416366

Variation tolerance for DR1 Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DR1 Gene

Disorders for DR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
stargardt disease
  • stargardt disease-1
metaphyseal chondrodysplasia, schmid type
  • corneal dystrophy, subepithelial mucinous
vulvitis
- elite association - COSMIC cancer census association via MalaCards
Search DR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DR1

Genetic Association Database (GAD)
DR1
Human Genome Epidemiology (HuGE) Navigator
DR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DR1
genes like me logo Genes that share disorders with DR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DR1 Gene

Publications for DR1 Gene

  1. Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. (PMID: 1339312) Inostroza J.A. … Reinberg D. (Cell 1992) 2 3 4 22 64
  2. Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. (PMID: 11461703) Kamada K. … Burley S.K. (Cell 2001) 3 4 22 64
  3. A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. (PMID: 8670811) Goppelt A.R. … Meisterernst M. (EMBO J. 1996) 3 4 22 64
  4. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. (PMID: 8836190) Cowell I.G. … Hurst H.C. (Nucleic Acids Res. 1996) 3 4 22 64
  5. Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. (PMID: 20230619) Albert T.K. … Meisterernst M. (Genome Biol. 2010) 3 22 64

Products for DR1 Gene

Sources for DR1 Gene

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