Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DR1 Gene

Aliases for DR1 Gene

  • Down-Regulator Of Transcription 1, TBP-Binding (Negative Cofactor 2) 2 3
  • TATA-Binding Protein-Associated Phosphoprotein 3 4
  • Negative Cofactor 2-Beta 3 4
  • NC2-BETA 3 4
  • Down-Regulator Of Transcription 1 4
  • Protein Dr1 3
  • NC2 3

External Ids for DR1 Gene

Previous GeneCards Identifiers for DR1 Gene

  • GC01P094217
  • GC01P093017
  • GC01P093162
  • GC01P093283
  • GC01P093256
  • GC01P093523
  • GC01P093811
  • GC01P091933

Summaries for DR1 Gene

Entrez Gene Summary for DR1 Gene

  • This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for DR1 Gene

DR1 (Down-Regulator Of Transcription 1, TBP-Binding (Negative Cofactor 2)) is a Protein Coding gene. Diseases associated with DR1 include stargardt disease. Among its related pathways are Chromatin Regulation / Acetylation and RNA Polymerase I Promoter Opening. GO annotations related to this gene include sequence-specific DNA binding and transcription factor binding.

UniProtKB/Swiss-Prot for DR1 Gene

  • The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for DR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DR1 Gene

Genomics for DR1 Gene

Regulatory Elements for DR1 Gene

Transcription factor binding sites by QIAGEN in the DR1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DR1 Gene

Start:
93,345,888 bp from pter
End:
93,369,498 bp from pter
Size:
23,611 bases
Orientation:
Plus strand

Genomic View for DR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DR1 Gene

Proteins for DR1 Gene

  • Protein details for DR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01658-NC2B_HUMAN
    Recommended name:
    Protein Dr1
    Protein Accession:
    Q01658
    Secondary Accessions:

    Protein attributes for DR1 Gene

    Size:
    176 amino acids
    Molecular mass:
    19444 Da
    Quaternary structure:
    • Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for DR1 Gene

neXtProt entry for DR1 Gene

Proteomics data for DR1 Gene at MOPED

Post-translational modifications for DR1 Gene

  • Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DR1 (DR1)

No data available for DME Specific Peptides for DR1 Gene

Domains for DR1 Gene

Suggested Antigen Peptide Sequences for DR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01658

UniProtKB/Swiss-Prot:

NC2B_HUMAN :
  • Q01658
Domain:
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the NC2 beta/DR1 family.
genes like me logo Genes that share domains with DR1: view

No data available for Gene Families for DR1 Gene

Function for DR1 Gene

Molecular function for DR1 Gene

GENATLAS Biochemistry: TATA binding (TBP) protein-associated phosphoprotein,(19kDa),expressed in Hela cells,inhibitor of class II and III genes transcription
UniProtKB/Swiss-Prot Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for DR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8670811
GO:0003714 transcription corepressor activity TAS 8670811
GO:0005515 protein binding IPI 18838386
GO:0008134 transcription factor binding TAS 1339312
GO:0017025 TBP-class protein binding IDA 18838386
genes like me logo Genes that share ontologies with DR1: view

Animal Model Products

CRISPR Products

miRNA for DR1 Gene

miRTarBase miRNAs that target DR1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DR1 Gene

Localization for DR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DR1 Gene COMPARTMENTS Subcellular localization image for DR1 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
genes like me logo Genes that share ontologies with DR1: view

Pathways for DR1 Gene

genes like me logo Genes that share pathways with DR1: view

Pathways by source for DR1 Gene

1 Cell Signaling Technology pathway for DR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8670811
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with DR1: view

Transcripts for DR1 Gene

mRNA/cDNA for DR1 Gene

Unigene Clusters for DR1 Gene

Down-regulator of transcription 1, TBP-binding (negative cofactor 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DR1 Gene

No ASD Table

Relevant External Links for DR1 Gene

GeneLoc Exon Structure for
DR1
ECgene alternative splicing isoforms for
DR1

Expression for DR1 Gene

mRNA expression in normal human tissues for DR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DR1 Gene

SOURCE GeneReport for Unigene cluster for DR1 Gene Hs.348418

genes like me logo Genes that share expressions with DR1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DR1 Gene

Orthologs for DR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DR1 35
  • 100 (n)
  • 100 (a)
DR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DR1 35
  • 94.89 (n)
  • 100 (a)
DR1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DR1 35
  • 93.94 (n)
  • 99.43 (a)
DR1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dr1 35
  • 93.18 (n)
  • 99.43 (a)
Dr1 16
Dr1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DR1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DR1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910207 35
  • 92.42 (n)
  • 99.43 (a)
chicken
(Gallus gallus)
Aves DR1 35
  • 85.8 (n)
  • 98.86 (a)
DR1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DR1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32418 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dr1 35
  • 83.72 (n)
  • 98.28 (a)
Str.1586 35
zebrafish
(Danio rerio)
Actinopterygii dr1 35
  • 79.81 (n)
  • 97.18 (a)
dr1 36
  • 94 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010322 35
  • 63.18 (n)
  • 67.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta NC2beta 35
  • 60.87 (n)
  • 68.12 (a)
NC2beta 36
  • 57 (a)
OneToOne
NC2bgr 37
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea dro-1 35
  • 54.2 (n)
  • 45.53 (a)
dro-1 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR397C 35
  • 44.27 (n)
  • 37.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NCB2 35
  • 50.79 (n)
  • 41.27 (a)
NCB2 36
  • 37 (a)
OneToOne
NCB2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06611g 35
  • 50.67 (n)
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NF-YB13 35
  • 58.13 (n)
  • 48.76 (a)
rice
(Oryza sativa)
Liliopsida Os08g0383700 35
  • 55.92 (n)
  • 47.93 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02017 35
  • 51.61 (n)
  • 46.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC30D10.02 35
  • 56.37 (n)
  • 51.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4043 36
  • 61 (a)
OneToOne
Species with no ortholog for DR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DR1 Gene

ENSEMBL:
Gene Tree for DR1 (if available)
TreeFam:
Gene Tree for DR1 (if available)

Paralogs for DR1 Gene

Selected SIMAP similar genes for DR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DR1: view

No data available for Paralogs for DR1 Gene

Variants for DR1 Gene

Sequence variations from dbSNP and Humsavar for DR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8489 -- 93,360,762(+) TCTAG(A/G)GATGT utr-variant-3-prime
rs8561 -- 93,360,898(+) GCAGC(A/G)AGTCC utr-variant-3-prime
rs10621 -- 93,362,327(-) TCGTT(A/C)TAGAC utr-variant-3-prime
rs771457 -- 93,361,899(+) TAGTG(A/T)TTATA utr-variant-3-prime
rs771458 -- 93,356,792(-) ATGAG(C/G)CGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DR1 Gene

Variant ID Type Subtype PubMed ID
nsv871640 CNV Loss 21882294

Relevant External Links for DR1 Gene

HapMap Linkage Disequilibrium report
DR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DR1 Gene

Disorders for DR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DR1 Gene including...

Search for DR1 Gene in MalaCards »

Relevant External Links for DR1

Genetic Association Database (GAD)
DR1
Human Genome Epidemiology (HuGE) Navigator
DR1
genes like me logo Genes that share disorders with DR1: view

No data available for UniProtKB/Swiss-Prot for DR1 Gene

Publications for DR1 Gene

  1. Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. (PMID: 1339312) Inostroza J.A. … Reinberg D. (Cell 1992) 2 3 4 23
  2. Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. (PMID: 11461703) Kamada K. … Burley S.K. (Cell 2001) 3 4 23
  3. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. (PMID: 8836190) Cowell I.G. … Hurst H.C. (Nucleic Acids Res. 1996) 3 4 23
  4. A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. (PMID: 8670811) Goppelt A.R. … Meisterernst M. (EMBO J. 1996) 3 4 23
  5. Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. (PMID: 8764062) Kashanchi F. … Brady J.N. (J. Virol. 1996) 3 23

Products for DR1 Gene

Sources for DR1 Gene

Back to Top

Content