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Aliases for DQX1 Gene

Aliases for DQX1 Gene

  • DEAQ-Box RNA Dependent ATPase 1 2 3 5
  • DEAQ Box Polypeptide 1 (RNA-Dependent ATPase) 2
  • DEAQ Box Polypeptide 1 4
  • EC 3.6.4.12 4

External Ids for DQX1 Gene

Previous GeneCards Identifiers for DQX1 Gene

  • GC02M074882
  • GC02M074958
  • GC02M074702
  • GC02M074719
  • GC02M074658
  • GC02M074659
  • GC02M074598
  • GC02M074745
  • GC02M074481

Summaries for DQX1 Gene

GeneCards Summary for DQX1 Gene

DQX1 (DEAQ-Box RNA Dependent ATPase 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DHX32.

Additional gene information for DQX1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DQX1 Gene

Genomics for DQX1 Gene

Regulatory Elements for DQX1 Gene

Enhancers for DQX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H074570 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -46.5 -46492 4 HDAC1 HDGF PKNOX1 FOXA2 ARID4B BMI1 ZBTB40 BATF RAD21 RARA DOK1 LBX2-AS1 AUP1 HTRA2 PCGF1 LBX2 TLX2 DQX1 MRPL53 MOGS
GH02H074575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -50.8 -50753 3 PKNOX1 MAX CEBPG ZBTB40 BATF RAD21 GATA3 POLR2A EED ETV6 DOK1 LOXL3 HTRA2 AUP1 DQX1 TLX2 PCGF1 LBX2 CCDC142 TTC31
GH02H074583 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -57.6 -57617 1 MAFG BACH1 JUNB DPF2 BATF JUND ZNF316 POLR2A FOS NFE2 LOXL3 DOK1 HTRA2 AUP1 TLX2 PCGF1 CCDC142 TTC31 DQX1 LBX2
GH02H074566 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -41.5 -41492 3 HLF CEBPB EBF1 EP300 JUND POLR2A GLIS1 IKZF1 SCRT2 FOS LBX2 WBP1 HTRA2 AUP1 TLX2 PCGF1 MRPL53 MOGS DQX1 RTKN
GH02H074487 1.2 ENCODE dbSUPER 11.8 +36.0 35998 4 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 TCF12 ATF7 SP5 LBX2 HTRA2 AUP1 DQX1 MOGS TLX2 WBP1 DOK1 LOXL3 CCDC142
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DQX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DQX1 Gene

Chromosome:
2
Start:
74,518,131 bp from pter
End:
74,526,336 bp from pter
Size:
8,206 bases
Orientation:
Minus strand

Genomic View for DQX1 Gene

Genes around DQX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DQX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DQX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DQX1 Gene

Proteins for DQX1 Gene

  • Protein details for DQX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE96-DQX1_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DQX1
    Protein Accession:
    Q8TE96
    Secondary Accessions:
    • Q6B017
    • Q8NAM8

    Protein attributes for DQX1 Gene

    Size:
    717 amino acids
    Molecular mass:
    79476 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DQX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DQX1 Gene

Post-translational modifications for DQX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DQX1 Gene

Domains & Families for DQX1 Gene

Gene Families for DQX1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DQX1 Gene

Suggested Antigen Peptide Sequences for DQX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DQX1: view

No data available for UniProtKB/Swiss-Prot for DQX1 Gene

Function for DQX1 Gene

Molecular function for DQX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DQX1 Gene

Gene Ontology (GO) - Molecular Function for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DQX1: view
genes like me logo Genes that share phenotypes with DQX1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DQX1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DQX1 Gene

Localization for DQX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DQX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DQX1 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DQX1: view

Pathways & Interactions for DQX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
genes like me logo Genes that share ontologies with DQX1: view

No data available for Pathways by source and SIGNOR curated interactions for DQX1 Gene

Drugs & Compounds for DQX1 Gene

(3) Drugs for DQX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DQX1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DQX1: view

Transcripts for DQX1 Gene

Unigene Clusters for DQX1 Gene

DEAQ box RNA-dependent ATPase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DQX1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DQX1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: -

Relevant External Links for DQX1 Gene

GeneLoc Exon Structure for
DQX1
ECgene alternative splicing isoforms for
DQX1

Expression for DQX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DQX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DQX1 Gene

This gene is overexpressed in Colon - Transverse (x17.0), Small Intestine - Terminal Ileum (x11.7), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for DQX1 Gene

This gene is overexpressed in Serum (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DQX1 Gene



Protein tissue co-expression partners for DQX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DQX1 Gene:

DQX1

SOURCE GeneReport for Unigene cluster for DQX1 Gene:

Hs.191705

Evidence on tissue expression from TISSUES for DQX1 Gene

  • Intestine(2.2)
genes like me logo Genes that share expression patterns with DQX1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DQX1 Gene

Orthologs for DQX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DQX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DQX1 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia DQX1 33 34
  • 88.52 (n)
cow
(Bos Taurus)
Mammalia DQX1 33 34
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Dqx1 33
  • 84.27 (n)
mouse
(Mus musculus)
Mammalia Dqx1 33 16 34
  • 84.08 (n)
oppossum
(Monodelphis domestica)
Mammalia DQX1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DQX1 33
  • 63.95 (n)
lizard
(Anolis carolinensis)
Reptilia DQX1 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01087670.1 34
  • 38 (a)
OneToOne
Dr.10422 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 34
  • 31 (a)
OneToMany
Species where no ortholog for DQX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DQX1 Gene

ENSEMBL:
Gene Tree for DQX1 (if available)
TreeFam:
Gene Tree for DQX1 (if available)

Paralogs for DQX1 Gene

Paralogs for DQX1 Gene

(8) SIMAP similar genes for DQX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DQX1: view

Variants for DQX1 Gene

Sequence variations from dbSNP and Humsavar for DQX1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000365630 -- 74,521,030(+) CTAGT(C/T)AGGAG intron-variant
rs1000740980 -- 74,522,374(+) GGAGA(C/G)ATTTA intron-variant
rs1000944255 -- 74,523,549(+) AGAAG(A/G)GTGGG intron-variant
rs1001504940 -- 74,521,581(+) CAGAC(-/AG)AGAGG intron-variant
rs1001978985 -- 74,525,337(+) GGCCA(A/G)CCTAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DQX1 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv1138785 CNV deletion 24896259
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for DQX1 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DQX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DQX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DQX1 Gene

Disorders for DQX1 Gene

Relevant External Links for DQX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DQX1

No disorders were found for DQX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DQX1 Gene

Publications for DQX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for DQX1 Gene

Sources for DQX1 Gene

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