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Aliases for DQX1 Gene

Aliases for DQX1 Gene

  • DEAQ Box RNA-Dependent ATPase 1 2 3
  • DEAQ Box Polypeptide 1 (RNA-Dependent ATPase) 2
  • DEAQ Box Polypeptide 1 4
  • EC 3.6.4.12 4

External Ids for DQX1 Gene

Previous GeneCards Identifiers for DQX1 Gene

  • GC02M074882
  • GC02M074958
  • GC02M074702
  • GC02M074719
  • GC02M074658
  • GC02M074659
  • GC02M074598
  • GC02M074745
  • GC02M074481

Summaries for DQX1 Gene

GeneCards Summary for DQX1 Gene

DQX1 (DEAQ Box RNA-Dependent ATPase 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DHX35.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DQX1 Gene

Genomics for DQX1 Gene

Regulatory Elements for DQX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DQX1 Gene

Chromosome:
2
Start:
74,518,131 bp from pter
End:
74,526,336 bp from pter
Size:
8,206 bases
Orientation:
Minus strand

Genomic View for DQX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DQX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DQX1 Gene

Proteins for DQX1 Gene

  • Protein details for DQX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE96-DQX1_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DQX1
    Protein Accession:
    Q8TE96
    Secondary Accessions:
    • Q6B017
    • Q8NAM8

    Protein attributes for DQX1 Gene

    Size:
    717 amino acids
    Molecular mass:
    79476 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DQX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DQX1 Gene

Proteomics data for DQX1 Gene at MOPED

Post-translational modifications for DQX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DQX1 Gene

No data available for DME Specific Peptides for DQX1 Gene

Domains & Families for DQX1 Gene

Protein Domains for DQX1 Gene

Suggested Antigen Peptide Sequences for DQX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE96

UniProtKB/Swiss-Prot:

DQX1_HUMAN :
  • Contains 1 helicase ATP-binding domain.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
genes like me logo Genes that share domains with DQX1: view

No data available for Gene Families for DQX1 Gene

Function for DQX1 Gene

Molecular function for DQX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DQX1 Gene

Gene Ontology (GO) - Molecular Function for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with DQX1: view
genes like me logo Genes that share phenotypes with DQX1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DQX1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DQX1 Gene

Localization for DQX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DQX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DQX1 Gene COMPARTMENTS Subcellular localization image for DQX1 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DQX1: view

Pathways & Interactions for DQX1 Gene

SuperPathways for DQX1 Gene

No Data Available

Interacting Proteins for DQX1 Gene

Gene Ontology (GO) - Biological Process for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DQX1: view

No data available for Pathways by source and SIGNOR curated interactions for DQX1 Gene

Drugs & Compounds for DQX1 Gene

(1) Drugs for DQX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DQX1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DQX1: view

Transcripts for DQX1 Gene

Unigene Clusters for DQX1 Gene

DEAQ box RNA-dependent ATPase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DQX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DQX1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: -

Relevant External Links for DQX1 Gene

GeneLoc Exon Structure for
DQX1
ECgene alternative splicing isoforms for
DQX1

Expression for DQX1 Gene

mRNA expression in normal human tissues for DQX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DQX1 Gene

This gene is overexpressed in Colon - Transverse (x17.0), Small Intestine - Terminal Ileum (x11.7), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for DQX1 Gene

This gene is overexpressed in Serum (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DQX1 Gene



SOURCE GeneReport for Unigene cluster for DQX1 Gene Hs.191705

genes like me logo Genes that share expression patterns with DQX1: view

Protein tissue co-expression partners for DQX1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DQX1 Gene

Orthologs for DQX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DQX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DQX1 35
  • 87.68 (n)
  • 86.33 (a)
DQX1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DQX1 35
  • 88.52 (n)
  • 88.01 (a)
DQX1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dqx1 35
  • 84.08 (n)
  • 84.93 (a)
Dqx1 16
Dqx1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DQX1 35
  • 99.54 (n)
  • 99.58 (a)
DQX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dqx1 35
  • 84.27 (n)
  • 85.07 (a)
oppossum
(Monodelphis domestica)
Mammalia DQX1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DQX1 35
  • 63.95 (n)
  • 62.29 (a)
lizard
(Anolis carolinensis)
Reptilia DQX1 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.10422 35
CABZ01087670.1 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 36
  • 31 (a)
OneToMany
Species with no ortholog for DQX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DQX1 Gene

ENSEMBL:
Gene Tree for DQX1 (if available)
TreeFam:
Gene Tree for DQX1 (if available)

Paralogs for DQX1 Gene

Paralogs for DQX1 Gene

(8) SIMAP similar genes for DQX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DQX1: view

Variants for DQX1 Gene

Sequence variations from dbSNP and Humsavar for DQX1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1306917 -- 74,521,776(-) aagag(A/G)gggag intron-variant
rs1306918 -- 74,521,766(-) gagag(A/G)gagag intron-variant
rs2286924 -- 74,518,165(+) CACAA(C/G)GGAGT utr-variant-3-prime
rs3815476 -- 74,518,046(+) ATAGT(C/T)GGAGG downstream-variant-500B
rs6546909 -- 74,519,195(+) AGGAG(A/T)AGGTA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for DQX1 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for DQX1 Gene

Residual Variation Intolerance Score: 31.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DQX1 Gene

HapMap Linkage Disequilibrium report
DQX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DQX1 Gene

Disorders for DQX1 Gene

Relevant External Links for DQX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DQX1
genes like me logo Genes that share disorders with DQX1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DQX1 Gene

Publications for DQX1 Gene

  1. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for DQX1 Gene

Sources for DQX1 Gene

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