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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPYSL5 Gene

protein-coding   GIFtS: 56
GCID: GC02P027070

dihydropyrimidinase-like 5
 Explore 21 diseases affiliated with
DPYSL5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DPYSL5    

Aliases
for DPYSL5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dihydropyrimidinase-Like 51 2     ULIP-62 3
CRAM1 2 3 5     CRMP3-Associated Molecule2 3
CRMP51 2 3 5     UNC33-Like Phosphoprotein 62 3
CRMP-51 2 3     Collapsin Response Mediator Protein-52
Ulip61 2     Dihydropyrimidinase-Related Protein 52
Collapsin Response Mediator Protein 52 3     ULIP63
DRP-52 3     

External Ids:    HGNC: 206371   Entrez Gene: 568962   Ensembl: ENSG000001578517   OMIM: 6083835   UniProtKB: Q9BPU63   

Export aliases for DPYSL5 gene to outside databases

Previous GC identifers: GC02P027163 GC02P027028 GC02P027045 GC02P026982 GC02P026812


Summaries
for DPYSL5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DPYSL5:
This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural
development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had
paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants,
encoding the same protein, have been identified. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: DPYL5_HUMAN, Q9BPU6
Function: May have a function in neuronal differentiation and/or axon growth

Gene Wiki entry for DPYSL5


Genomic Views
for DPYSL5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPYSL5 gene promoter:
         GR   RFX1   AML1a   AP-4   POU3F2   HNF-4alpha1   Ik-2   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DPYSL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPYSL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYSL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

DPYSL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPYSL5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027070:  view genomic region     (about GC identifiers)

Start:
 27,070,615 bp from pter      End:
 27,173,219 bp from pter
Size:
 102,605 bases      Orientation:
 plus strand

Proteins
for DPYSL5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPYL5_HUMAN, Q9BPU6 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 5  
Size: 564 amino acids; 61421 Da
Subunit: Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By
similarity)
Subcellular location: Cytoplasm (Probable)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
3 PDB 3D structures from and Proteopedia for DPYSL5:
4B90 (3D)        4B91 (3D)        4B92 (3D)    
Secondary accessions: Q8TCL6 Q9NQC4 Q9NRY9

Explore the universe of human proteins at neXtProt for DPYSL5: NX_Q9BPU6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BPU6

    • DPYSL5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001240652.1  NP_001240653.1  NP_064519.2  

    ENSEMBL proteins: 
     ENSP00000407174   ENSP00000288699   ENSP00000385549   ENSP00000399581   ENSP00000413075  
    Reactome Protein details: Q9BPU6
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: DPYSL5
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    Novus Biologicals DPYSL5 Proteins
    Novus Biologicals DPYSL5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DPYSL5

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--
    GO:0043234protein complex IEA--


    DPYSL5 for ontologies           About GeneDecksing



    DPYSL5 Antibody Products: 
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    ThermoFisher Antibody for DPYSL5

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    Uscn ELISAs and CLIAs for DPYSL5

    Protein Domains /
    Families
    for DPYSL5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DPYSL5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR006680 Amidohydro_1
     IPR011059 Metal-dep_hydrolase_composite

    Graphical View of Domain Structure for InterPro Entry Q9BPU6

    ProtoNet protein and cluster: Q9BPU6

    1 Blocks protein family: IPB005847 Dihydroorotase region

    UniProtKB/Swiss-Prot: DPYL5_HUMAN, Q9BPU6
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    Function
    for DPYSL5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPYL5_HUMAN, Q9BPU6
    Function: May have a function in neuronal differentiation and/or axon growth

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DPYSL5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPYSL5
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate DPYSL5 (see all 97):
    hsa-miR-520e hsa-miR-3146 hsa-miR-106a hsa-miR-128 hsa-miR-3138 hsa-miR-93 hsa-miR-642b hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmid: DPYSL5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPYSL5 (see all 7)
    OriGene shRNA RFP: DPYSL5
    OriGene siRNA: DPYSL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPYSL5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DPYSL5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPYSL5 (see all 3)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYSL5 

    Cell Line
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    Search LifeMap BioReagents cell lines for DPYSL5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL5

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--


    DPYSL5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DPYSL5:
     Increased gamma-H2AX phosphory 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dpysl5):
     behavior/neurological  nervous system 

    DPYSL5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DPYSL5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Beta-alanine metabolism
    		thymine degradation0.25
    		uracil degradation II (reductive)0.25
    3Semaphorin Signaling
    		Semaphorin Signaling1.00
    4Guidance Cues and Growth Cone Motility
    		Guidance Cues and Growth Cone Motility1.00
    5Axon guidance
    		Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DPYSL5
        Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    2 BioSystems Pathways for DPYSL5 
        thymine degradation
    uracil degradation II (reductive)

    4        Reactome Pathways for DPYSL5
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for DPYSL5):
        Axon guidance


    DPYSL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPYSL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for DPYSL5 (Q9BPU62, 3 ENSP000002886994) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110212, 3, ENSP000003241734MINT-65304 I2D: score=4 STRING: ENSP00000324173
    FESP073323, ENSP000003315044I2D: score=1 STRING: ENSP00000331504
    DPYSQ141173, ENSP000002766514I2D: score=1 STRING: ENSP00000276651
    DPYSL2Q165553, ENSP000003095394I2D: score=1 STRING: ENSP00000309539
    DPYSL3Q141953, ENSP000003815264I2D: score=1 STRING: ENSP00000381526
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007165signal transduction TAS10851247
    GO:0007399nervous system development TAS10851247
    GO:0007411axon guidance TAS--
    GO:0030182neuron differentiation ----


    DPYSL5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DPYSL5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPYSL5
    Search CenterWatch for drugs/clinical trials and news about DPYSL5 / DPYL5 

    Transcripts
    for DPYSL5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DPYSL5 gene (3 alternative transcripts): 
    NM_001253723.1  NM_001253724.1  NM_020134.3  

    Unigene Cluster for DPYSL5:

    Dihydropyrimidinase-like 5
    Hs.299315  [show with all ESTs]
    Unigene Representative Sequence: NM_020134
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450961 ENST00000288699(uc002rhu.4 uc002rhv.4 uc021vev.1)
    ENST00000401478 ENST00000431402 ENST00000434719 ENST00000484882

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPYSL5
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate DPYSL5 (see all 97):
    hsa-miR-520e hsa-miR-3146 hsa-miR-106a hsa-miR-128 hsa-miR-3138 hsa-miR-93 hsa-miR-642b hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmid: DPYSL5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPYSL5 (see all 7)
    OriGene shRNA RFP: DPYSL5
    OriGene siRNA: DPYSL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPYSL5
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DPYSL5 (NM_020134)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPYSL5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPYSL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPYSL5

    Additional cDNA sequence: 

    AF157634.1 AF264015.1 AJ251275.1 AK022795.1 AL713706.1 BC002874.2 BC128218.1 BT006871.1 

    7 DOTS entries:

    DT.115427  DT.100687209  DT.95369962  DT.120987134  DT.120987135  DT.403679  DT.91751218 

    11 AceView cDNA sequences:

    AI498064 BF512328 AA058664 AA350414 BI600253 BE791584 BI598740 AI879238 
    AW294757 AA351100 AI571188 

    GeneLoc Exon Structure


    Expression
    for DPYSL5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPYSL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCCTGTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DPYSL5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DPYSL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPYSL5

    SOURCE GeneReport for Unigene cluster: Hs.299315
        SABiosciences Custom PCR Arrays for DPYSL5
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL5

    Orthologs
    for DPYSL5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DPYSL5 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DPYSL56
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343593.1(168024-202569)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.111332 Transcribed sequence with weak similarity to protein more 76.05(n)    BI533508.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dhp-26
    dhp-16
    (see all 3)    		 Dihydropyrimidinase 1
    (see all 3)    		 47(a)
    46(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 IV(9978165-9980749)
    I(7238996-7243965)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PYD26
    		 pyrimidine 2
    		 37(a)
    		 1 → many
    		 5(3941528-3944811)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 dihydropyrimidinase, putative, expressed
    		 38(a)
    		 1 → many
    		 1(34294608-34306006)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria hyuA6
    		 D-stereospecific phenylhydantoinase
    		 34(a)
    		 1 → many
    		 Chromosome(3008050-3009435)


    ENSEMBL Gene Tree for DPYSL5 (if available)
    TreeFam Gene Tree for DPYSL5 (if available) 

    Paralogs
    for DPYSL5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPYSL5 gene
    CRMP12  DPYSL32  DPYSL42  DPYS2  DPYSL22  
    5 SIMAP similar genes for DPYSL5 using alignment to 6 protein entries:     DPYL5_HUMAN (see all proteins):
    DPYSL2    DPYSL3    CRMP1    DPYSL4    DPYS

    DPYSL5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DPYSL5
    PGOHUM00000242301


    Genomic Variants
    for DPYSL5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1678 NCBI SNPs in DPYSL5 are shown (see all 1678)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs67145791,2
    		C,F,--26811176(+) AGGTCA/GAGTCG 1 -- us2k1 tfbs36Minor allele frequency- G:0.14NA WA CSA 246
    rs1445847451,2
    		--27069008(+) GGAGCA/TAAGGG 1 -- us2k10--------
    rs348164651,2
    		C,F,--27069117(+) TCTACT/CTCCCA 1 -- us2k13Minor allele frequency- C:0.04NA 124
    rs1163813111,2
    		C,--27069179(+) ATATGC/TAACCC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs67176821,2
    		C,F,A,--27069211(+) TCAATA/GTCCTA 2 -- us2k115Minor allele frequency- G:0.34NA EA WA CSA 736
    rs739233961,2
    		C,--27069313(+) GAGACG/CCTGCA 3 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1888731181,2
    		--27069345(+) AGGGCG/TCTCTC 3 -- us2k10--------
    rs781351821,2
    		C,--27069386(+) CGCGCG/CGTAGT 3 -- us2k12Minor allele frequency- C:0.09WA 120
    rs1179276581,2
    		F,--27069479(+) CGGGCA/TAGCCC 3 -- us2k11Minor allele frequency- T:0.02EA 120
    rs2006188511,2
    		C--27069527(-) GGCTGG/TGAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPYSL5 (27070615 - 27173219 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DPYSL5: --

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    Disorders / Diseases
    for DPYSL5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DPYSL5 for disorders           About GeneDecksing

    OMIM gene information: 608383    OMIM disorders: --

    20/21 diseases for DPYSL5 (see all 21):    About MalaCards
    stiff-person syndrome    paraneoplastic syndromes    non-hodgkin lymphoma    optic neuritis
    dihydropyrimidinuria    myelitis    neuritis    hodgkin's lymphoma
    thymoma    neuroendocrine carcinoma    down syndrome    lung carcinoma
    encephalitis    carcinoma    neuropathy    lung cancer
    pneumonia    retinitis    tuberculosis    neuronitis

    6 diseases from the University of Copenhagen DISEASES database for DPYSL5:
    Encephalitis     Thymoma     Neuropathy     Lung cancer
    Cerebellar ataxia     Visual pathway disease

    5 Novoseek disease relationships for DPYSL5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung carcinoma 63.2 2 14673901 (1), 12838519 (1)
    thymoma 62.9 6 17657489 (5), 14673901 (1)
    autoimmunity 34 1 11558786 (1)
    carcinoma 18.9 1 11558786 (1)
    cancer 18.9 3 17657489 (1), 18347453 (1), 18306241 (1)


    Export disorders for DPYSL5 gene to outside databases

    Publications
    for DPYSL5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPYSL5 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with DPYSL5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain. (PubMed id 11034345)1, 2, 3, 9 Horiuchi M....Betz H. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma- related autoimmunity. (PubMed id 11220734)1, 2 Yu Z....Lennon V.A. (2001)
    4. Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain. (PubMed id 10851247)1, 3 Inatome R....Yanagi S. (2000)
    5. Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma. (PubMed id 18769332)1, 9 Meyronet D....Thomasset N. (2008)
    6. High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma. (PubMed id 18347453)1, 9 Margolin E....Trobe J.D. (2008)
    7. Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G. (PubMed id 18306241)1, 9 Keegan B.M....Lennon V.A. (2008)
    8. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. (PubMed id 12838519)1, 9 Cross S.A....Lennon V.A. (2003)
    9. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for DPYSL5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DPYSL5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56896 HGNC: 20637 AceView: DPYSL5 Ensembl:ENSG00000157851 euGenes: HUgn56896
    ECgene: DPYSL5 Kegg: 56896 H-InvDB: DPYSL5

    Other Databases showing DPYSL5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DPYSL5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPYSL5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DPYSL5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DPYSL5 gene:
    Search GeneIP for patents involving DPYSL5

    GeneCards and IP:
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