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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPYSL5 Gene

protein-coding   GIFtS: 57
GCID: GC02P027070

Dihydropyrimidinase-Like 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dihydropyrimidinase-Like 51 2     CRMP3-Associated Molecule2 3
CRAM2 3 5     UNC33-Like Phosphoprotein 62 3
CRMP52 3 5     Ulip62
Collapsin Response Mediator Protein 52 3     Collapsin Response Mediator Protein-52
CRMP-52 3     Dihydropyrimidinase-Related Protein 52
DRP-52 3     ULIP63
ULIP-62 3     

External Ids:    HGNC: 206371   Entrez Gene: 568962   Ensembl: ENSG000001578517   OMIM: 6083835   UniProtKB: Q9BPU63   

Export aliases for DPYSL5 gene to outside databases

Previous GC identifers: GC02P027163 GC02P027028 GC02P027045 GC02P026982 GC02P026812


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPYSL5 Gene:
This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in
neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who
had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced
variants, encoding the same protein, have been identified. (provided by RefSeq, Dec 2011)

GeneCards Summary for DPYSL5 Gene: 
DPYSL5 (dihydropyrimidinase-like 5) is a protein-coding gene. Diseases associated with DPYSL5 include paraneoplastic syndromes, and stiff-person syndrome, and among its related super-pathways are superpathway of pyrimidine ribonucleosides degradation and Axon guidance. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot: DPYL5_HUMAN, Q9BPU6
Function: May have a function in neuronal differentiation and/or axon growth

Gene Wiki entry for DPYSL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPYSL5 gene promoter:
         GR   RFX1   AML1a   AP-4   POU3F2   HNF-4alpha1   Ik-2   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPYSL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPYSL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYSL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

DPYSL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPYSL5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027070:  view genomic region     (about GC identifiers)

Start:
27,070,615 bp from pter      End:
27,173,219 bp from pter
Size:
102,605 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPYL5_HUMAN, Q9BPU6 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 5  
Size: 564 amino acids; 61421 Da
Subunit: Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4
(By similarity)
Subcellular location: Cytoplasm (Probable)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
3 PDB 3D structures from and Proteopedia for DPYSL5:
4B90 (3D)        4B91 (3D)        4B92 (3D)    
Secondary accessions: Q8TCL6 Q9NQC4 Q9NRY9

Explore the universe of human proteins at neXtProt for DPYSL5: NX_Q9BPU6

Explore proteomics data for DPYSL5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BPU6

  • DPYSL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPYSL5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001240652.1  NP_001240653.1  NP_064519.2  

    ENSEMBL proteins: 
     ENSP00000407174   ENSP00000288699   ENSP00000385549   ENSP00000399581   ENSP00000413075  
    Reactome Protein details: Q9BPU6
    Human Recombinant Protein Products for DPYSL5: 
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    Novus Biologicals DPYSL5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DPYSL5 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--
    GO:0043234protein complex IEA--

    DPYSL5 for ontologies           About GeneDecksing



    DPYSL5 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DPYSL5 

    Assay Products for DPYSL5: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR006680 Amidohydro_1
     IPR011059 Metal-dep_hydrolase_composite

    Graphical View of Domain Structure for InterPro Entry Q9BPU6

    ProtoNet protein and cluster: Q9BPU6

    1 Blocks protein domain: IPB005847 Dihydroorotase region

    UniProtKB/Swiss-Prot: DPYL5_HUMAN, Q9BPU6
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    DPYSL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPYL5_HUMAN, Q9BPU6
    Function: May have a function in neuronal differentiation and/or axon growth

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--
         
    DPYSL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DPYSL5:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dpysl5):
     behavior/neurological  nervous system 

    DPYSL5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPYSL5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DPYSL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPYSL5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPYSL5 

    miRNA
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    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate DPYSL5 (see all 97):
    hsa-miR-520e hsa-miR-3146 hsa-miR-106a hsa-miR-128 hsa-miR-3138 hsa-miR-93 hsa-miR-642b hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidDPYSL5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DPYSL5 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1thymine degradation
    thymine degradation0.60
    uracil degradation I (reductive)0.60
    superpathway of pyrimidine ribonucleosides degradation0.60
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Sema4D in semaphorin signaling
    Semaphorin interactions0.41
    4SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    CRMPs in Sema3A signaling0.36
    5Semaphorin Signaling
    Semaphorin Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DPYSL5
        Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    3 BioSystems Pathways for DPYSL5
        uracil degradation I (reductive)
    thymine degradation
    superpathway of pyrimidine ribonucleosides degradation

    4        Reactome Pathways for DPYSL5
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for DPYSL5):
        Axon guidance


    DPYSL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPYSL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for DPYSL5 (Q9BPU62, 3 ENSP000002886994) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110212, 3, ENSP000003241734MINT-65304 I2D: score=4 STRING: ENSP00000324173
    FESP073323, ENSP000003315044I2D: score=1 STRING: ENSP00000331504
    DPYSQ141173, ENSP000002766514I2D: score=1 STRING: ENSP00000276651
    DPYSL2Q165553, ENSP000003095394I2D: score=1 STRING: ENSP00000309539
    DPYSL3Q141953, ENSP000003815264I2D: score=1 STRING: ENSP00000381526
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007165signal transduction TAS10851247
    GO:0007399nervous system development TAS10851247
    GO:0007411axon guidance TAS--
    GO:0030182neuron differentiation ----

    DPYSL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPYSL5 (DPYL5)

    Search CenterWatch for drugs/clinical trials and news about DPYSL5 / DPYL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPYSL5 gene (3 alternative transcripts): 
    NM_001253723.1  NM_001253724.1  NM_020134.3  

    Unigene Cluster for DPYSL5:

    Dihydropyrimidinase-like 5
    Hs.299315  [show with all ESTs]
    Unigene Representative Sequence: NM_020134
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450961 ENST00000288699(uc002rhu.4 uc002rhv.4 uc021vev.1)
    ENST00000401478 ENST00000431402 ENST00000434719 ENST00000484882
    miRNA
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    hsa-miR-520e hsa-miR-3146 hsa-miR-106a hsa-miR-128 hsa-miR-3138 hsa-miR-93 hsa-miR-642b hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidDPYSL5 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPYSL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPYSL5

    Additional mRNA sequence: 

    AF157634.1 AF264015.1 AJ251275.1 AK022795.1 AL713706.1 BC002874.2 BC128218.1 BT006871.1 

    7 DOTS entries:

    DT.115427  DT.100687209  DT.95369962  DT.120987134  DT.120987135  DT.403679  DT.91751218 

    11 AceView cDNA sequences:

    AI498064 BF512328 AA350414 AA058664 AI879238 BI598740 BE791584 BI600253 
    AA351100 AI571188 AW294757 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPYSL5 expression in normal human tissues (normalized intensities)      DPYSL5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCTGTGCT
    DPYSL5 Expression
    About this image


    DPYSL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             subthalamic nucleus   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
             sperm   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
             pancreas ; exocrine glandular cells   
     
     Peripheral Nervous System (Nervous System)
             colon ; peripheral nerve/ganglion   

    See DPYSL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPYSL5

    SOURCE GeneReport for Unigene cluster: Hs.299315
        SABiosciences Custom PCR Arrays for DPYSL5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DPYSL5 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpysl51 , 5 dihydropyrimidinase-like 51, 5 90.43(n)1
    97.87(a)1
      5 (16.80 cM)5
    652541  NM_023047.21  NP_075534.11 
     307115645 
    chicken
    (Gallus gallus)
    Aves DPYSL56
    dihydropyrimidinase-like 5
    74(a)
    1 ↔ 1
    AADN03026785.1(21-1534)
    lizard
    (Anolis carolinensis)
    Reptilia DPYSL56
    --
    --
    93(a)
    23(a)
    1 ↔ 1
    possible ortholog
    GL343593.1(166170-230155)
    3(35153312-35184148)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.111332 Transcribed sequence with weak similarity to protein more 76.05(n)    BI533508.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61066
    --
    22(a)
    possible ortholog
    X(18252916-18255995)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-336
    Protein unc-33
    22(a)
    possible ortholog
    IV(3516821-3526602)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAL16
    Allantoinase, converts allantoin to allantoate in ...
    21(a)
    1 → many
    IX(406260-407642)


    ENSEMBL Gene Tree for DPYSL5 (if available)
    TreeFam Gene Tree for DPYSL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPYSL5 gene
    DPYSL32  CRMP12  DPYSL42  DPYS2  DPYSL22  
    5 SIMAP similar genes for DPYSL5 using alignment to 6 protein entries:     DPYL5_HUMAN (see all proteins):
    DPYSL2    DPYSL3    CRMP1    DPYSL4    DPYS

    DPYSL5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DPYSL5
    PGOHUM00000242301


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1944 SNPs in DPYSL5 are shown (see all 1944)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs67145791,2
    C,F--26811176(+) AGGTCA/GAGTCG 1 -- us2k1 tfbs36Minor allele frequency- G:0.14NA WA CSA 246
    rs348164651,2
    C,F--26811249(+) TCTACT/CTCCCA 1 -- us2k13Minor allele frequency- C:0.04NA 124
    rs1163813111,2
    C,F--26811311(+) ATATGC/TAACCC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs67176821,2
    C,F,A--26811343(+) TCAATA/GTCCTA 1 -- us2k115Minor allele frequency- G:0.34NA EA WA CSA 736
    rs105859551,2
    C--26876392(+) AAACA-/TAGAGAA 3 -- int11Minor allele frequency- TA:0.00NA 2
    rs1445847451,2
    --27069008(+) GGAGCA/TAAGGG 1 -- us2k10--------
    rs739233961,2
    C,F--27069313(+) GAGACG/CCTGCA 3 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1888731181,2
    --27069345(+) AGGGCG/TCTCTC 3 -- us2k10--------
    rs781351821,2
    C,F--27069386(+) CGCGCG/CGTAGT 3 -- us2k12Minor allele frequency- C:0.09WA 120
    rs1179276581,2
    F--27069479(+) CGGGCA/TAGCCC 3 -- us2k11Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for DPYSL5 (27070615 - 27173219 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DPYSL5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1993351CNV Deletion18987734
    nsv214236CNV Insertion16902084
    esv1009796CNV Insertion20482838
    esv275060CNV Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608383    OMIM disorders: --

    18 diseases for DPYSL5:    About MalaCards
    paraneoplastic syndromes    stiff-person syndrome    myelitis    thymoma
    optic neuritis    neuritis    neuroendocrine carcinoma    cerebellar ataxia
    encephalitis    down syndrome    non-hodgkin lymphoma    hodgkin's lymphoma
    neuropathy    ataxia    tuberculosis    retinitis
    lung cancer    neuronitis

    6 diseases from the University of Copenhagen DISEASES database for DPYSL5:
    Encephalitis     Thymoma     Neuropathy     Lung cancer
    Visual pathway disease     Cerebellar ataxia

    DPYSL5 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for DPYSL5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung carcinoma 63.2 2 14673901 (1), 12838519 (1)
    thymoma 62.9 6 17657489 (5), 14673901 (1)
    autoimmunity 34 1 11558786 (1)
    carcinoma 18.9 1 11558786 (1)
    cancer 18.9 3 17657489 (1), 18347453 (1), 18306241 (1)


    Export disorders for DPYSL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPYSL5 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with DPYSL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain. (PubMed id 11034345)1, 2, 3, 9 Horiuchi M....Betz H. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma- related autoimmunity. (PubMed id 11220734)1, 2 Yu Z....Lennon V.A. (2001)
    4. Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain. (PubMed id 10851247)1, 3 Inatome R....Yanagi S. (2000)
    5. Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma. (PubMed id 18769332)1, 9 Meyronet D....Thomasset N. (2008)
    6. High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma. (PubMed id 18347453)1, 9 Margolin E....Trobe J.D. (2008)
    7. Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G. (PubMed id 18306241)1, 9 Keegan B.M....Lennon V.A. (2008)
    8. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. (PubMed id 12838519)1, 9 Cross S.A....Lennon V.A. (2003)
    9. Insights into the oligomerization of CRMPs: crystal st ructure of human collapsin response mediator protein 5. (PubMed id 23373749)1 Ponnusamy R. and Lohkamp B. (2013)
    10. Identification of a new CRMP5 isoform present in the n ucleus of cancer cells and enhancing their proliferation. (PubMed id 23298946)1 Brot S....Moradi-Ameli M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56896 HGNC: 20637 AceView: DPYSL5 Ensembl:ENSG00000157851 euGenes: HUgn56896
    ECgene: DPYSL5 Kegg: 56896 H-InvDB: DPYSL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPYSL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPYSL5 gene:
    Search GeneIP for patents involving DPYSL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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