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Aliases for DPYSL5 Gene

Aliases for DPYSL5 Gene

  • Dihydropyrimidinase Like 5 2 3 5
  • UNC33-Like Phosphoprotein 6 3 4
  • CRMP3-Associated Molecule 3 4
  • CRMP-5 3 4
  • ULIP-6 3 4
  • Ulip6 3 4
  • CRMP5 3 4
  • DRP-5 3 4
  • CRAM 3 4
  • Collapsin Response Mediator Protein-5 3
  • Dihydropyrimidinase-Related Protein 5 3
  • Collapsin Response Mediator Protein 5 4
  • Dihydropyrimidinase-Like 5 2

External Ids for DPYSL5 Gene

Previous GeneCards Identifiers for DPYSL5 Gene

  • GC02P027163
  • GC02P027028
  • GC02P027045
  • GC02P026982
  • GC02P026812
  • GC02P027070

Summaries for DPYSL5 Gene

Entrez Gene Summary for DPYSL5 Gene

  • This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for DPYSL5 Gene

DPYSL5 (Dihydropyrimidinase Like 5) is a Protein Coding gene. Diseases associated with DPYSL5 include Thymoma and Thymus Cancer. Among its related pathways are Developmental Biology and Semaphorin Signaling. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is DPYS.

UniProtKB/Swiss-Prot for DPYSL5 Gene

  • May have a function in neuronal differentiation and/or axon growth.

Gene Wiki entry for DPYSL5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL5 Gene

Genomics for DPYSL5 Gene

Regulatory Elements for DPYSL5 Gene

Enhancers for DPYSL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G026849 1.5 FANTOM5 ENCODE dbSUPER 22.3 +1.6 1556 0.2 HDGF ZNF76 SIN3A RAD21 ZNF335 GLIS2 EGR1 ZNF366 KLF7 RELB DPYSL5 KHK MAPRE3 OTOF DRC1 UCN PIR42524
GH02G026766 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -77.7 -77739 6.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ENSG00000272148 KHK AGBL5-IT1 DPYSL5 MAPRE3 SNX17 ADGRF3 CENPA CDKN2AIPNLP2
GH02G026911 1.3 ENCODE dbSUPER 11.9 +65.6 65564 3.0 HDGF ATF1 ARNT SIN3A ARID4B DMAP1 ZNF48 YY1 ZNF766 ZNF143 KHK DPYSL5 MAPRE3 PREB PIR42524
GH02G026970 1.4 FANTOM5 ENCODE 10.5 +123.9 123881 2.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YY1 ZNF143 ZNF207 KHK LOC100129724 LOC105374337 AGBL5 AGBL5-AS1 DPYSL5 EMILIN1 SLC5A6 ATRAID MAPRE3
GH02G026924 1.2 ENCODE dbSUPER 12 +77.8 77801 1.1 ELF3 TBP FOXA2 ARID4B DMAP1 ZNF48 RARA EGR1 CREM EGR2 KHK DPYSL5 MAPRE3 LOC100129724 LOC105374337 EMILIN1 PIR42524
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPYSL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPYSL5 Gene

Chromosome:
2
Start:
26,847,747 bp from pter
End:
26,950,351 bp from pter
Size:
102,605 bases
Orientation:
Plus strand

Genomic View for DPYSL5 Gene

Genes around DPYSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL5 Gene

Proteins for DPYSL5 Gene

  • Protein details for DPYSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPU6-DPYL5_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 5
    Protein Accession:
    Q9BPU6
    Secondary Accessions:
    • Q8TCL6
    • Q9NQC4
    • Q9NRY9

    Protein attributes for DPYSL5 Gene

    Size:
    564 amino acids
    Molecular mass:
    61421 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DPYSL5 Gene

neXtProt entry for DPYSL5 Gene

Post-translational modifications for DPYSL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL5 Gene

Antibody Products

  • Abcam antibodies for DPYSL5
  • Cloud-Clone Corp. Antibodies for DPYSL5

No data available for DME Specific Peptides for DPYSL5 Gene

Domains & Families for DPYSL5 Gene

Suggested Antigen Peptide Sequences for DPYSL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPU6

UniProtKB/Swiss-Prot:

DPYL5_HUMAN :
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with DPYSL5: view

No data available for Gene Families for DPYSL5 Gene

Function for DPYSL5 Gene

Molecular function for DPYSL5 Gene

UniProtKB/Swiss-Prot Function:
May have a function in neuronal differentiation and/or axon growth.

Gene Ontology (GO) - Molecular Function for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with DPYSL5: view
genes like me logo Genes that share phenotypes with DPYSL5: view

Animal Models for DPYSL5 Gene

MGI Knock Outs for DPYSL5:

Animal Model Products

CRISPR Products

miRNA for DPYSL5 Gene

miRTarBase miRNAs that target DPYSL5

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPYSL5 Gene

Localization for DPYSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYSL5 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with DPYSL5: view

Pathways & Interactions for DPYSL5 Gene

genes like me logo Genes that share pathways with DPYSL5: view

Pathways by source for DPYSL5 Gene

1 KEGG pathway for DPYSL5 Gene

Gene Ontology (GO) - Biological Process for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10851247
GO:0007399 nervous system development TAS 10851247
GO:0007411 axon guidance TAS,IEA --
genes like me logo Genes that share ontologies with DPYSL5: view

No data available for SIGNOR curated interactions for DPYSL5 Gene

Drugs & Compounds for DPYSL5 Gene

No Compound Related Data Available

Transcripts for DPYSL5 Gene

mRNA/cDNA for DPYSL5 Gene

Unigene Clusters for DPYSL5 Gene

Dihydropyrimidinase-like 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL5 Gene

No ASD Table

Relevant External Links for DPYSL5 Gene

GeneLoc Exon Structure for
DPYSL5
ECgene alternative splicing isoforms for
DPYSL5

Expression for DPYSL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPYSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.4), Brain - Substantia nigra (x5.9), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Putamen (basal ganglia) (x5.0), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for DPYSL5 Gene

This gene is overexpressed in Fetal Brain (28.8), Spinal cord (11.2), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPYSL5 Gene



Protein tissue co-expression partners for DPYSL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPYSL5 Gene:

DPYSL5

SOURCE GeneReport for Unigene cluster for DPYSL5 Gene:

Hs.299315

Evidence on tissue expression from TISSUES for DPYSL5 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with DPYSL5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYSL5 Gene

Orthologs for DPYSL5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPYSL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPYSL5 34 35
  • 99.59 (n)
oppossum
(Monodelphis domestica)
Mammalia DPYSL5 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL5 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPYSL5 34 35
  • 92.43 (n)
cow
(Bos Taurus)
Mammalia DPYSL5 34 35
  • 92.02 (n)
rat
(Rattus norvegicus)
Mammalia Dpysl5 34
  • 91.08 (n)
mouse
(Mus musculus)
Mammalia Dpysl5 34 16 35
  • 90.43 (n)
chicken
(Gallus gallus)
Aves DPYSL5 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL5 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl5 34
  • 76.28 (n)
zebrafish
(Danio rerio)
Actinopterygii dpysl5b 35
  • 76 (a)
OneToMany
dpysl5a 34 35
  • 74.41 (n)
Dr.11133 34
fruit fly
(Drosophila melanogaster)
Insecta CRMP 35
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhp-2 35
  • 47 (a)
ManyToMany
unc-33 35
  • 23 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C19107g 34
  • 45.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
Species where no ortholog for DPYSL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL5 Gene

ENSEMBL:
Gene Tree for DPYSL5 (if available)
TreeFam:
Gene Tree for DPYSL5 (if available)

Paralogs for DPYSL5 Gene

Paralogs for DPYSL5 Gene

(5) SIMAP similar genes for DPYSL5 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DPYSL5 Gene

genes like me logo Genes that share paralogs with DPYSL5: view

Variants for DPYSL5 Gene

Sequence variations from dbSNP and Humsavar for DPYSL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000014281 -- 26,857,781(+) GTGAT(A/T)TTTAC intron-variant
rs1000091783 -- 26,849,406(+) GGCGC(C/G)GGGCC intron-variant
rs1000123583 -- 26,894,748(+) TACTC(A/C)CAGAG intron-variant
rs1000152359 -- 26,867,244(+) GGGTG(C/T)CCAGG intron-variant
rs1000187712 -- 26,848,410(+) TTGGG(G/T)TTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPYSL5 Gene

Variant ID Type Subtype PubMed ID
esv1009796 CNV insertion 20482838
esv1993351 CNV deletion 18987734
esv275060 CNV loss 21479260
esv3416312 CNV insertion 20981092
esv3423223 CNV duplication 20981092
nsv214236 CNV insertion 16902084

Variation tolerance for DPYSL5 Gene

Residual Variation Intolerance Score: 8.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPYSL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPYSL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL5 Gene

Disorders for DPYSL5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DPYSL5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thymoma
  • thymus neoplasms
thymus cancer
  • neoplasm of thymus
neuroretinitis
  • focal retinitis and retinochoroiditis, juxtapapillary
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DPYSL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPYSL5
genes like me logo Genes that share disorders with DPYSL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL5 Gene

Publications for DPYSL5 Gene

  1. Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain. (PMID: 11034345) Horiuchi M. … Betz H. (FEBS Lett. 2000) 2 3 4 22 64
  2. Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G. (PMID: 18306241) Keegan B.M. … Lennon V.A. (Ann. Neurol. 2008) 3 22 64
  3. High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma. (PMID: 18347453) Margolin E. … Trobe J.D. (J Neuroophthalmol 2008) 3 22 64
  4. Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma. (PMID: 18769332) Meyronet D. … Thomasset N. (Am. J. Surg. Pathol. 2008) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DPYSL5 Gene

Sources for DPYSL5 Gene

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