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Aliases for DPYSL5 Gene

Aliases for DPYSL5 Gene

  • Dihydropyrimidinase Like 5 2 3 5
  • Collapsin Response Mediator Protein 5 3 4
  • UNC33-Like Phosphoprotein 6 3 4
  • Dihydropyrimidinase-Like 5 2 3
  • CRMP3-Associated Molecule 3 4
  • CRMP-5 3 4
  • ULIP-6 3 4
  • Ulip6 3 4
  • CRMP5 3 4
  • DRP-5 3 4
  • CRAM 3 4
  • Collapsin Response Mediator Protein-5 3

External Ids for DPYSL5 Gene

Previous GeneCards Identifiers for DPYSL5 Gene

  • GC02P027163
  • GC02P027028
  • GC02P027045
  • GC02P026982
  • GC02P026812
  • GC02P027070

Summaries for DPYSL5 Gene

Entrez Gene Summary for DPYSL5 Gene

  • This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for DPYSL5 Gene

DPYSL5 (Dihydropyrimidinase Like 5) is a Protein Coding gene. Diseases associated with DPYSL5 include thymoma and thymus cancer. Among its related pathways are Developmental Biology and Axon guidance. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot for DPYSL5 Gene

  • May have a function in neuronal differentiation and/or axon growth.

Gene Wiki entry for DPYSL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL5 Gene

Genomics for DPYSL5 Gene

Regulatory Elements for DPYSL5 Gene

Promoters for DPYSL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPYSL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPYSL5 Gene

Chromosome:
2
Start:
26,847,747 bp from pter
End:
26,950,351 bp from pter
Size:
102,605 bases
Orientation:
Plus strand

Genomic View for DPYSL5 Gene

Genes around DPYSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL5 Gene

Proteins for DPYSL5 Gene

  • Protein details for DPYSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPU6-DPYL5_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 5
    Protein Accession:
    Q9BPU6
    Secondary Accessions:
    • Q8TCL6
    • Q9NQC4
    • Q9NRY9

    Protein attributes for DPYSL5 Gene

    Size:
    564 amino acids
    Molecular mass:
    61421 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DPYSL5 Gene

neXtProt entry for DPYSL5 Gene

Proteomics data for DPYSL5 Gene at MOPED

Post-translational modifications for DPYSL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL5 Gene

Antibody Products

No data available for DME Specific Peptides for DPYSL5 Gene

Domains & Families for DPYSL5 Gene

Suggested Antigen Peptide Sequences for DPYSL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPU6

UniProtKB/Swiss-Prot:

DPYL5_HUMAN :
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with DPYSL5: view

No data available for Gene Families for DPYSL5 Gene

Function for DPYSL5 Gene

Molecular function for DPYSL5 Gene

UniProtKB/Swiss-Prot Function:
May have a function in neuronal differentiation and/or axon growth.

Gene Ontology (GO) - Molecular Function for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with DPYSL5: view
genes like me logo Genes that share phenotypes with DPYSL5: view

Animal Models for DPYSL5 Gene

MGI Knock Outs for DPYSL5:

Animal Model Products

miRNA for DPYSL5 Gene

miRTarBase miRNAs that target DPYSL5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPYSL5 Gene

Localization for DPYSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPYSL5 Gene COMPARTMENTS Subcellular localization image for DPYSL5 gene
Compartment Confidence
cytosol 5
cytoskeleton 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with DPYSL5: view

Pathways & Interactions for DPYSL5 Gene

genes like me logo Genes that share pathways with DPYSL5: view

Pathways by source for DPYSL5 Gene

1 KEGG pathway for DPYSL5 Gene

Gene Ontology (GO) - Biological Process for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10851247
genes like me logo Genes that share ontologies with DPYSL5: view

No data available for SIGNOR curated interactions for DPYSL5 Gene

Drugs & Compounds for DPYSL5 Gene

No Compound Related Data Available

Transcripts for DPYSL5 Gene

mRNA/cDNA for DPYSL5 Gene

Unigene Clusters for DPYSL5 Gene

Dihydropyrimidinase-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL5 Gene

No ASD Table

Relevant External Links for DPYSL5 Gene

GeneLoc Exon Structure for
DPYSL5
ECgene alternative splicing isoforms for
DPYSL5

Expression for DPYSL5 Gene

mRNA expression in normal human tissues for DPYSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.4), Brain - Substantia nigra (x5.9), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Putamen (basal ganglia) (x5.0), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for DPYSL5 Gene

This gene is overexpressed in Fetal Brain (28.8), Spinal cord (11.2), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPYSL5 Gene



SOURCE GeneReport for Unigene cluster for DPYSL5 Gene Hs.299315

genes like me logo Genes that share expression patterns with DPYSL5: view

Protein tissue co-expression partners for DPYSL5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DPYSL5 Gene

Orthologs for DPYSL5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPYSL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPYSL5 36
  • 100 (a)
OneToOne
DPYSL5 35
  • 99.59 (n)
  • 99.82 (a)
cow
(Bos Taurus)
Mammalia DPYSL5 36
  • 99 (a)
OneToOne
DPYSL5 35
  • 92.02 (n)
  • 98.94 (a)
dog
(Canis familiaris)
Mammalia DPYSL5 35
  • 92.43 (n)
  • 98.76 (a)
DPYSL5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpysl5 16
Dpysl5 35
  • 90.43 (n)
  • 97.87 (a)
Dpysl5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPYSL5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL5 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpysl5 35
  • 91.08 (n)
  • 97.87 (a)
chicken
(Gallus gallus)
Aves DPYSL5 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL5 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl5 35
  • 76.28 (n)
  • 83.44 (a)
zebrafish
(Danio rerio)
Actinopterygii dpysl5a 36
  • 79 (a)
OneToMany
dpysl5b 36
  • 76 (a)
OneToMany
dpysl5a 35
  • 74.41 (n)
  • 80.5 (a)
Dr.11133 35
fruit fly
(Drosophila melanogaster)
Insecta CRMP 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhp-2 36
  • 47 (a)
ManyToMany
unc-33 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL1 36
  • 22 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C19107g 35
  • 45.92 (n)
  • 35.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
Species with no ortholog for DPYSL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL5 Gene

ENSEMBL:
Gene Tree for DPYSL5 (if available)
TreeFam:
Gene Tree for DPYSL5 (if available)

Paralogs for DPYSL5 Gene

Paralogs for DPYSL5 Gene

(5) SIMAP similar genes for DPYSL5 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DPYSL5 Gene

genes like me logo Genes that share paralogs with DPYSL5: view

Variants for DPYSL5 Gene

Sequence variations from dbSNP and Humsavar for DPYSL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs486582 -- 26,881,263(+) CCAGA(C/T)GCGAT intron-variant
rs515048 -- 26,884,522(-) GTGTG(A/T)GAGAT intron-variant
rs827882 -- 26,888,046(-) ACTAA(A/T)GGGAA intron-variant
rs827883 -- 26,879,909(-) tgtct(C/T)aacaa intron-variant
rs530476 -- 26,866,246(-) ATTTC(A/C)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL5 Gene

Variant ID Type Subtype PubMed ID
esv1009796 CNV Insertion 20482838
nsv214236 CNV Insertion 16902084
esv1993351 CNV Deletion 18987734
esv275060 CNV Loss 21479260

Variation tolerance for DPYSL5 Gene

Residual Variation Intolerance Score: 8.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPYSL5 Gene

HapMap Linkage Disequilibrium report
DPYSL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL5 Gene

Disorders for DPYSL5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DPYSL5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thymoma
  • primary thymic epithelial neoplasm
thymus cancer
  • neoplasm of thymus
neuroretinitis
  • focal retinitis and retinochoroiditis, juxtapapillary
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DPYSL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPYSL5
genes like me logo Genes that share disorders with DPYSL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL5 Gene

Publications for DPYSL5 Gene

  1. Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain. (PMID: 11034345) Horiuchi M. … Betz H. (FEBS Lett. 2000) 2 3 4 23 67
  2. Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G. (PMID: 18306241) Keegan B.M. … Lennon V.A. (Ann. Neurol. 2008) 3 23
  3. High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma. (PMID: 18347453) Margolin E. … Trobe J.D. (J Neuroophthalmol 2008) 3 23
  4. Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma. (PMID: 18769332) Meyronet D. … Thomasset N. (Am. J. Surg. Pathol. 2008) 3 23
  5. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. (PMID: 12838519) Cross S.A. … Lennon V.A. (Ann. Neurol. 2003) 3 23

Products for DPYSL5 Gene

Sources for DPYSL5 Gene

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