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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPYSL4 Gene

protein-coding   GIFtS: 56
GCID: GC10P134000

dihydropyrimidinase-like 4
 Explore 10 diseases affiliated with
DPYSL4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DPYSL4    

Aliases
for DPYSL4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dihydropyrimidinase-Like 41 2     CRMP-32 3
ULIP41 2 3 5     ULIP-42 3
DRP-41 2 3     UNC33-Like Phosphoprotein 42 3
CRMP32 3 5     Dihydropyrimidinase-Related Protein 42
Collapsin Response Mediator Protein 32 3     

External Ids:    HGNC: 30161   Entrez Gene: 105702   Ensembl: ENSG000001516407   OMIM: 6084075   UniProtKB: O145313   

Export aliases for DPYSL4 gene to outside databases

Previous GC identifers: GC10P132911 GC10P133133 GC10P133877 GC10P133434 GC10P133850 GC10P127552


Summaries
for DPYSL4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DPYL4_HUMAN, O14531
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in
axon guidance, neuronal growth cone collapse and cell migration (By similarity)

Gene Wiki entry for DPYSL4


Genomic Views
for DPYSL4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPYSL4 gene promoter:
         Pax-2b   COMP1   ATF-2   NRSF form 1   Pax-2   c-Jun   Pax-2a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DPYSL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPYSL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYSL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q25.2-q26

DPYSL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPYSL4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P134000:  view genomic region     (about GC identifiers)

Start:
 134,000,404 bp from pter      End:
 134,019,280 bp from pter
Size:
 18,877 bases      Orientation:
 plus strand

Proteins
for DPYSL4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPYL4_HUMAN, O14531 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 4  
Size: 572 amino acids; 61878 Da
Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By similarity)
Subcellular location: Cytoplasm (By similarity)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
Secondary accessions: B2RMQ1 D3DRG5 O00240 Q5T0Q7

Explore the universe of human proteins at neXtProt for DPYSL4: NX_O14531

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14531

    • DPYSL4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006417.2  
    ENSEMBL proteins: 
     ENSP00000339850   ENSP00000357616   ENSP00000357618  
    Reactome Protein details: O14531
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: DPYSL4
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    Novus Biologicals DPYSL4 Proteins
    Novus Biologicals DPYSL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DPYSL4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    DPYSL4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DPYSL4

    Protein Domains /
    Families
    for DPYSL4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DPYSL4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR006680 Amidohydro_1
     IPR011059 Metal-dep_hydrolase_composite

    Graphical View of Domain Structure for InterPro Entry O14531

    ProtoNet protein and cluster: O14531

    1 Blocks protein family: IPB005847 Dihydroorotase region

    UniProtKB/Swiss-Prot: DPYL4_HUMAN, O14531
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    Function
    for DPYSL4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPYL4_HUMAN, O14531
    Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in
    axon guidance, neuronal growth cone collapse and cell migration (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPYSL4
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DPYSL4 (see all 13):
    hsa-miR-125a-5p hsa-miR-34c-5p hsa-miR-449b hsa-miR-1283 hsa-miR-548v hsa-miR-449a hsa-miR-3157-5p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmid: DPYSL4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPYSL4 (see all 7)
    OriGene shRNA RFP: DPYSL4
    OriGene siRNA: DPYSL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPYSL4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DPYSL4

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYSL4 

    Cell Line
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    Search LifeMap BioReagents cell lines for DPYSL4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016787hydrolase activity ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--


    DPYSL4 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Dpysl4):
     nervous system 

    DPYSL4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DPYSL4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Beta-alanine metabolism
    		thymine degradation0.25
    		uracil degradation II (reductive)0.25
    3Sema4D in semaphorin signaling
    		Semaphorin interactions0.44
    4SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    		CRMPs in Sema3A signaling0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for DPYSL4 
        thymine degradation
    uracil degradation II (reductive)

    4        Reactome Pathways for DPYSL4
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Axon guidance



    DPYSL4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPYSL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for DPYSL4 (O145312, 3 ENSP000003398504) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPROQ168272, 3, ENSP000002811714MINT-8267665 I2D: score=2 STRING: ENSP00000281171
    DPYSL2Q165552, 3, ENSP000003095394MINT-8254556 I2D: score=2 STRING: ENSP00000309539
    SH3GL1Q999612, 3, ENSP000002698864MINT-8270341 I2D: score=2 STRING: ENSP00000269886
    SH3GL2Q999622, 3, ENSP000003699814MINT-8270429 I2D: score=2 STRING: ENSP00000369981
    DPYSL5Q9BPU63, ENSP000002886994I2D: score=2 STRING: ENSP00000288699
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007399nervous system development TAS9652388
    GO:0007411axon guidance TAS--


    DPYSL4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DPYSL4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPYSL4
    Search CenterWatch for drugs/clinical trials and news about DPYSL4 / DPYL4 

    Transcripts
    for DPYSL4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DPYSL4 gene: 
    NM_006426.2  

    Unigene Cluster for DPYSL4:

    Dihydropyrimidinase-like 4
    Hs.100058  [show with all ESTs]
    Unigene Representative Sequence: NM_006426
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338492(uc009ybb.3) ENST00000493927 ENST00000493882 ENST00000368627
    ENST00000471544 ENST00000368629

    miRNA
    Products:             		 OriGene 3'-UTR Clone: DPYSL4
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DPYSL4 (see all 13):
    hsa-miR-125a-5p hsa-miR-34c-5p hsa-miR-449b hsa-miR-1283 hsa-miR-548v hsa-miR-449a hsa-miR-3157-5p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmid: DPYSL4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPYSL4 (see all 7)
    OriGene shRNA RFP: DPYSL4
    OriGene siRNA: DPYSL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPYSL4
    Clone
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    GenScript: all cDNA clones in your preferred vector: DPYSL4 (NM_006426)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPYSL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYSL4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPYSL4
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPYSL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPYSL4

    Additional cDNA sequence: 

    AB006713.1 BC029280.1 BC136329.1 BC136330.1 BC142974.1 Y10976.1 

    6 DOTS entries:

    DT.85102382  DT.95372638  DT.100788427  DT.97781692  DT.97812817  DT.121248701 

    24/79 AceView cDNA sequences (see all 79):

    BQ218478 BC029280 BX282178 BM927995 BM928281 BM547750 BM679953 BM920859 
    BQ186495 BM927042 BU072554 BX442264 BG910622 BM930650 BM718225 BQ956921 
    BQ068024 BM723755 AW771374 AI337037 CA943411 CB177875 BM925929 Y10976 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                  
    SP2:                                            -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for DPYSL4

    Expression
    for DPYSL4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPYSL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCACCCACCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DPYSL4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DPYSL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPYSL4

    SOURCE GeneReport for Unigene cluster: Hs.100058
        SABiosciences Expression via Pathway-Focused PCR Arrays including DPYSL4: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL4

    Orthologs
    for DPYSL4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DPYSL4 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DPYSL46
    		 dihydropyrimidinase-like 4
    		 82(a)
    		 1 ↔ 1
    		 6(36879449-36889907)
    lizard
    (Anolis carolinensis)    		 Reptilia DPYSL46
    		 --
    		 71(a)
    		 1 ↔ 1
    		 3(58060417-58105993)
    zebrafish
    (Danio rerio)    		 Actinopterygii dpysl41 dihydropyrimidinase-like 4 70.13(n)
    71.58(a)    		   553411  NM_001020516.1  NP_001018352.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dhp-13 dihydropyrimidinase 48(a)
    (best of 3)    		   I(7247149-7251818)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PYD26
    		 pyrimidine 2
    		 40(a)
    		 1 → many
    		 5(3941528-3944811)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 dihydropyrimidinase, putative, expressed
    		 41(a)
    		 1 → many
    		 1(34294608-34306006)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria hyuA6
    		 D-stereospecific phenylhydantoinase
    		 33(a)
    		 1 → many
    		 Chromosome(3008050-3009435)


    ENSEMBL Gene Tree for DPYSL4 (if available)
    TreeFam Gene Tree for DPYSL4 (if available) 

    Paralogs
    for DPYSL4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPYSL4 gene
    CRMP12  DPYSL32  DPYSL52  DPYS2  DPYSL22  
    5 SIMAP similar genes for DPYSL4 using alignment to 3 protein entries:     DPYL4_HUMAN (see all proteins):
    DPYSL2    CRMP1    DPYSL3    DPYS    DPYSL5

    DPYSL4 for paralogs           About GeneDecksing



    Genomic Variants
    for DPYSL4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/645 NCBI SNPs in DPYSL4 are shown (see all 645)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1153211201,2
    		F,--133998536(+) GACCAC/GCTGGG 2 -- ds5001 us2k11Minor allele frequency- G:0.07WA 118
    rs1488135861,2
    		--133998552(+) CCCTCC/TTGTGG 2 -- ds5001 us2k10--------
    rs1870292371,2
    		--133998575(+) TGTGAA/GCCATG 2 -- us2k1 ds50010--------
    rs1469363501,2
    		--133998650(+) TTTGCC/TGTGGA 2 -- ds5001 us2k10--------
    rs1914993361,2
    		--133998675(+) TGAGTA/TACAGA 2 -- us2k1 ds50010--------
    rs1836906821,2
    		--133998720(+) GAGGAC/GGACGA 2 -- ds5001 us2k10--------
    rs1476353661,2
    		--133998822(+) AAATGA/CGGACT 1 -- us2k10--------
    rs1168222471,2
    		C,F,--133998873(+) TCAGCT/CGCTGC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs758927141,2
    		C--133998878(+) TGCTGA/CAGGCT 1 -- us2k10--------
    rs779909961,2
    		C--133998880(+) CTGCAG/TGCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPYSL4 (134000404 - 134019280 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for DPYSL4
         2 CNVs: 71169 4717
         4 Indels: 75441 24390 24389 85545

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    Disorders / Diseases
    for DPYSL4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DPYSL4 for disorders           About GeneDecksing

    OMIM gene information: 608407    OMIM disorders: --

    10 diseases for DPYSL4:    About MalaCards
    dihydropyrimidinuria    down syndrome    thymoma    lung cancer
    ischemia    pneumonia    cerebritis    tuberculosis
    neuronitis    mycobacterium tuberculosis


    Export disorders for DPYSL4 gene to outside databases

    Publications
    for DPYSL4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPYSL4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with DPYSL4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ulip family phosphoproteins -- common and specific properties. (PubMed id 9652388)1, 2, 3 Byk T.... Sobel A. (1998)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 3 Hamajima N.... Nonaka M. (1996)
    4. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to D NA damage. (PubMed id 20499313)1 Kimura J....Yoshida K. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for DPYSL4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing DPYSL4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10570 HGNC: 3016 AceView: DPYSL4 Ensembl:ENSG00000151640 euGenes: HUgn10570
    ECgene: DPYSL4 H-InvDB: DPYSL4

    Other Databases showing DPYSL4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DPYSL4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPYSL4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DPYSL4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DPYSL4 gene:
    Search GeneIP for patents involving DPYSL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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