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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPYSL4 Gene

protein-coding   GIFtS: 56
GCID: GC10P134000

Dihydropyrimidinase-Like 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dihydropyrimidinase-Like 41 2     DRP-42 3
CRMP32 3 5     ULIP-42 3
ULIP42 3 5     UNC33-Like Phosphoprotein 42 3
Collapsin Response Mediator Protein 32 3     Dihydropyrimidinase-Related Protein 42
CRMP-32 3     

External Ids:    HGNC: 30161   Entrez Gene: 105702   Ensembl: ENSG000001516407   OMIM: 6084075   UniProtKB: O145313   

Export aliases for DPYSL4 gene to outside databases

Previous GC identifers: GC10P132911 GC10P133133 GC10P133877 GC10P133434 GC10P133850 GC10P127552


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DPYSL4 Gene: 
DPYSL4 (dihydropyrimidinase-like 4) is a protein-coding gene. Diseases associated with DPYSL4 include thymoma, and down syndrome, and among its related super-pathways are superpathway of pyrimidine ribonucleosides degradation and Axon guidance. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot: DPYL4_HUMAN, O14531
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)

Gene Wiki entry for DPYSL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008818.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPYSL4 gene promoter:
         Pax-2b   COMP1   ATF-2   NRSF form 1   Pax-2   c-Jun   Pax-2a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPYSL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPYSL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYSL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q25.2-q26

DPYSL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPYSL4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P134000:  view genomic region     (about GC identifiers)

Start:
134,000,404 bp from pter      End:
134,019,280 bp from pter
Size:
18,877 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPYL4_HUMAN, O14531 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 4  
Size: 572 amino acids; 61878 Da
Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By
similarity)
Subcellular location: Cytoplasm (By similarity)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
Secondary accessions: B2RMQ1 D3DRG5 O00240 Q5T0Q7

Explore the universe of human proteins at neXtProt for DPYSL4: NX_O14531

Explore proteomics data for DPYSL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14531

  • DPYSL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPYSL4 Protein Expression
    REFSEQ proteins: NP_006417.2  
    ENSEMBL proteins: 
     ENSP00000339850   ENSP00000357616   ENSP00000357618  
    Reactome Protein details: O14531
    Human Recombinant Protein Products for DPYSL4: 
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    Cloud-Clone Corp. Proteins for DPYSL4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    DPYSL4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR006680 Amidohydro_1
     IPR011059 Metal-dep_hydrolase_composite

    Graphical View of Domain Structure for InterPro Entry O14531

    ProtoNet protein and cluster: O14531

    1 Blocks protein domain: IPB005847 Dihydroorotase region

    UniProtKB/Swiss-Prot: DPYL4_HUMAN, O14531
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    DPYSL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPYL4_HUMAN, O14531
    Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
    role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--
         
    DPYSL4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dpysl4):
     nervous system 

    DPYSL4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPYSL4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPYSL4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPYSL4 

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DPYSL4 (see all 13):
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    SwitchGear 3'UTR luciferase reporter plasmidDPYSL4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DPYSL4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1thymine degradation
    thymine degradation0.60
    uracil degradation I (reductive)0.60
    superpathway of pyrimidine ribonucleosides degradation0.60
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Sema4D in semaphorin signaling
    Semaphorin interactions0.41
    4SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    CRMPs in Sema3A signaling0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for DPYSL4
        uracil degradation I (reductive)
    thymine degradation
    superpathway of pyrimidine ribonucleosides degradation

    4        Reactome Pathways for DPYSL4
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Axon guidance



    DPYSL4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPYSL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for DPYSL4 (O145312, 3 ENSP000003398504) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPROQ168272, 3, ENSP000002811714MINT-8267665 I2D: score=2 STRING: ENSP00000281171
    DPYSL2Q165552, 3, ENSP000003095394MINT-8254556 I2D: score=2 STRING: ENSP00000309539
    SH3GL1Q999612, 3, ENSP000002698864MINT-8270341 I2D: score=2 STRING: ENSP00000269886
    SH3GL2Q999622, 3, ENSP000003699814MINT-8270429 I2D: score=2 STRING: ENSP00000369981
    DPYSL5Q9BPU63, ENSP000002886994I2D: score=2 STRING: ENSP00000288699
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007399nervous system development TAS9652388
    GO:0007411axon guidance TAS--
    GO:0048666neuron development ----

    DPYSL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPYSL4 (DPYL4)

    Search CenterWatch for drugs/clinical trials and news about DPYSL4 / DPYL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPYSL4 gene: 
    NM_006426.2  

    Unigene Cluster for DPYSL4:

    Dihydropyrimidinase-like 4
    Hs.100058  [show with all ESTs]
    Unigene Representative Sequence: NM_006426
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338492(uc009ybb.3) ENST00000493927 ENST00000493882 ENST00000368627
    ENST00000471544 ENST00000368629
    miRNA
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    hsa-miR-125a-5p hsa-miR-34c-5p hsa-miR-449b hsa-miR-1283 hsa-miR-548v hsa-miR-449a hsa-miR-3157-5p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidDPYSL4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB006713.1 BC029280.1 BC136329.1 BC136330.1 BC142974.1 Y10976.1 

    6 DOTS entries:

    DT.85102382  DT.95372638  DT.100788427  DT.97781692  DT.97812817  DT.121248701 

    24/79 AceView cDNA sequences (see all 79):

    BM927042 BM547750 BU072554 BM920859 BQ218478 BQ186495 BM679953 BM927995 
    BM928281 BC029280 BX282178 CB177875 AI870829 AI337037 AW771374 BQ187811 
    AW513689 BM925929 BF530817 BQ070243 AA632348 BI084406 BX442264 BM930650 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                  
    SP2:                                            -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for DPYSL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPYSL4 expression in normal human tissues (normalized intensities)      DPYSL4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACCCACCG
    DPYSL4 Expression
    About this image


    DPYSL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Human Hippocampal Astrocytes   
             ganglion/cranial   
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Retina
             Human Keratocyte (HK)   
             retinal progenitor cell e16.5   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Schwann Precursor Cells Peripheral Nerve Domain
             spinal/ganglion/dorsal root ganglion   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   

    See DPYSL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPYSL4

    SOURCE GeneReport for Unigene cluster: Hs.100058
        SABiosciences Expression via Pathway-Focused PCR Arrays including DPYSL4: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DPYSL4 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpysl41 , 5 dihydropyrimidinase-like 41, 5 86.31(n)1
    93.36(a)1
      7 (83.92 cM)5
    267571  NM_011993.41  NP_036123.31 
     1390860015 
    chicken
    (Gallus gallus)
    Aves DPYSL46
    Uncharacterized protein
    82(a)
    1 ↔ 1
    6(34398117-34408511)
    lizard
    (Anolis carolinensis)
    Reptilia DPYSL46
    --
    --
    71(a)
    21(a)
    1 ↔ 1
    possible ortholog
    3(58060138-58110153)
    3(35153312-35184148)
    zebrafish
    (Danio rerio)
    Actinopterygii dpysl41 dihydropyrimidinase-like 4 70.13(n)
    71.58(a)
      553411  NM_001020516.1  NP_001018352.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CRMP3 dihydropyrimidinase 47(a)   83B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea dhp-13 dihydropyrimidinase 48(a)
    (best of 3)
      I(7247149-7251818)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAL16
    Allantoinase, converts allantoin to allantoate in ...
    18(a)
    1 → many
    IX(406260-407642)


    ENSEMBL Gene Tree for DPYSL4 (if available)
    TreeFam Gene Tree for DPYSL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPYSL4 gene
    DPYSL32  CRMP12  DPYSL52  DPYS2  DPYSL22  
    5 SIMAP similar genes for DPYSL4 using alignment to 3 protein entries:     DPYL4_HUMAN (see all proteins):
    DPYSL2    CRMP1    DPYSL3    DPYS    DPYSL5

    DPYSL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/833 SNPs in DPYSL4 are shown (see all 833)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476353661,2
    --133998822(+) AAATGA/CGGACT 1 -- us2k10--------
    rs1168222471,2
    C,F--133998873(+) TCAGCT/CGCTGC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs758927141,2
    C--133998878(+) TGCTGA/CAGGCT 1 -- us2k10--------
    rs779909961,2
    C--133998880(+) CTGCAG/TGCTGG 1 -- us2k10--------
    rs798813091,2
    C--133998881(+) TGCAGG/TCTGGG 1 -- us2k10--------
    rs1423059841,2
    --133998995(+) CACCCC/TACCCC 1 -- us2k10--------
    rs733997511,2
    C,F--133999016(+) CCACAC/ATCGCC 1 -- us2k13Minor allele frequency- A:0.08WA CSA 121
    rs743268901,2
    C,F--133999043(+) GGGCTT/GTCTTG 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1459275561,2
    --133999126(+) CCCCGC/TCCGGC 1 -- us2k10--------
    rs1160192341,2
    F--133999167(+) AGCAGC/TCACGC 1 -- us2k11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for DPYSL4 (134000404 - 134019280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for DPYSL4 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv134e201CNV Deletion23290073
    esv1577545CNV Deletion17803354
    esv2743632CNV Deletion23290073
    esv1008205CNV Deletion20482838
    esv2743634CNV Deletion23290073
    esv1089089CNV Deletion17803354
    esv2743628CNV Deletion23290073
    esv2743633CNV Deletion23290073
    esv2743635CNV Deletion23290073
    nsv896140CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608407    OMIM disorders: --

    7 diseases for DPYSL4:    About MalaCards
    thymoma    down syndrome    ischemia    tuberculosis
    cerebritis    lung cancer    neuronitis


    DPYSL4 for disorders           About GeneDecksing


    Export disorders for DPYSL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPYSL4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with DPYSL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ulip family phosphoproteins -- common and specific properties. (PubMed id 9652388)1, 2, 3 Byk T.... Sobel A. (1998)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 3 Hamajima N.... Nonaka M. (1996)
    4. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to D NA damage. (PubMed id 20499313)1 Kimura J....Yoshida K. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. (PubMed id 12134159)1 Fukata Y....Kaibuchi K. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10570 HGNC: 3016 AceView: DPYSL4 Ensembl:ENSG00000151640 euGenes: HUgn10570
    ECgene: DPYSL4 H-InvDB: DPYSL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPYSL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPYSL4 gene:
    Search GeneIP for patents involving DPYSL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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