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Aliases for DPYSL4 Gene

Aliases for DPYSL4 Gene

  • Dihydropyrimidinase-Like 4 2 3
  • Collapsin Response Mediator Protein 3 3 4
  • UNC33-Like Phosphoprotein 4 3 4
  • CRMP-3 3 4
  • ULIP-4 3 4
  • CRMP3 3 4
  • DRP-4 3 4
  • ULIP4 3 4

External Ids for DPYSL4 Gene

Previous GeneCards Identifiers for DPYSL4 Gene

  • GC10P132911
  • GC10P133133
  • GC10P133877
  • GC10P133434
  • GC10P133850
  • GC10P134000
  • GC10P127552

Summaries for DPYSL4 Gene

GeneCards Summary for DPYSL4 Gene

DPYSL4 (Dihydropyrimidinase-Like 4) is a Protein Coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot for DPYSL4 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Wiki entry for DPYSL4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL4 Gene

Genomics for DPYSL4 Gene

Regulatory Elements for DPYSL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPYSL4 Gene

Chromosome:
10
Start:
132,184,987 bp from pter
End:
132,205,776 bp from pter
Size:
20,790 bases
Orientation:
Plus strand

Genomic View for DPYSL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPYSL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL4 Gene

Proteins for DPYSL4 Gene

  • Protein details for DPYSL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14531-DPYL4_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 4
    Protein Accession:
    O14531
    Secondary Accessions:
    • B2RMQ1
    • D3DRG5
    • O00240
    • Q5T0Q7

    Protein attributes for DPYSL4 Gene

    Size:
    572 amino acids
    Molecular mass:
    61878 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By similarity).

neXtProt entry for DPYSL4 Gene

Proteomics data for DPYSL4 Gene at MOPED

Post-translational modifications for DPYSL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DPYSL4 Gene

Domains & Families for DPYSL4 Gene

Protein Domains for DPYSL4 Gene

Suggested Antigen Peptide Sequences for DPYSL4 Gene

Graphical View of Domain Structure for InterPro Entry

O14531

UniProtKB/Swiss-Prot:

DPYL4_HUMAN :
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with DPYSL4: view

No data available for Gene Families for DPYSL4 Gene

Function for DPYSL4 Gene

Molecular function for DPYSL4 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with DPYSL4: view

Phenotypes for DPYSL4 Gene

genes like me logo Genes that share phenotypes with DPYSL4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPYSL4 Gene

Localization for DPYSL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPYSL4 Gene COMPARTMENTS Subcellular localization image for DPYSL4 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DPYSL4: view

Pathways & Interactions for DPYSL4 Gene

genes like me logo Genes that share pathways with DPYSL4: view

Pathways by source for DPYSL4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9652388
GO:0007411 axon guidance TAS --
GO:0008152 metabolic process IEA --
GO:0048666 neuron development --
GO:0070997 neuron death IEA --
genes like me logo Genes that share ontologies with DPYSL4: view

No data available for SIGNOR curated interactions for DPYSL4 Gene

Drugs & Compounds for DPYSL4 Gene

No Compound Related Data Available

Transcripts for DPYSL4 Gene

Unigene Clusters for DPYSL4 Gene

Dihydropyrimidinase-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3:

Relevant External Links for DPYSL4 Gene

GeneLoc Exon Structure for
DPYSL4
ECgene alternative splicing isoforms for
DPYSL4

Expression for DPYSL4 Gene

mRNA expression in normal human tissues for DPYSL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL4 Gene

This gene is overexpressed in Brain - Cortex (x4.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for DPYSL4 Gene

This gene is overexpressed in Brain (33.6), Fetal Brain (14.9), and Retina (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPYSL4 Gene



SOURCE GeneReport for Unigene cluster for DPYSL4 Gene Hs.100058

genes like me logo Genes that share expression patterns with DPYSL4: view

Protein tissue co-expression partners for DPYSL4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DPYSL4 Gene

Orthologs for DPYSL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPYSL4 35
  • 86.25 (n)
  • 89.51 (a)
DPYSL4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPYSL4 35
  • 87.49 (n)
  • 92.35 (a)
DPYSL4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpysl4 35
  • 86.31 (n)
  • 93.36 (a)
Dpysl4 16
Dpysl4 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPYSL4 35
  • 98.95 (n)
  • 99.3 (a)
DPYSL4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpysl4 35
  • 86.07 (n)
  • 93.53 (a)
oppossum
(Monodelphis domestica)
Mammalia DPYSL4 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL4 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPYSL4 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL4 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl4 35
  • 71.97 (n)
  • 80.94 (a)
zebrafish
(Danio rerio)
Actinopterygii dpysl4 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CRMP 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-1 37
  • 48 (a)
dhp-2 37
  • 47 (a)
unc-33 37
  • 34 (a)
Species with no ortholog for DPYSL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL4 Gene

ENSEMBL:
Gene Tree for DPYSL4 (if available)
TreeFam:
Gene Tree for DPYSL4 (if available)

Paralogs for DPYSL4 Gene

Paralogs for DPYSL4 Gene

(5) SIMAP similar genes for DPYSL4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DPYSL4: view

Variants for DPYSL4 Gene

Sequence variations from dbSNP and Humsavar for DPYSL4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12313 -- 132,203,791(+) CGTGG(A/G)CTGTA reference, synonymous-codon
rs15448 -- 132,203,834(+) CCAAG(A/C)CAGGG missense, reference
rs871883 -- 132,200,352(+) GTGCT(G/T)CAGGG intron-variant
rs881346 -- 132,186,469(-) CCTTG(C/G)CCAAA upstream-variant-2KB, intron-variant
rs881347 -- 132,186,626(-) AGTCC(A/G)GCCAC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL4 Gene

Variant ID Type Subtype PubMed ID
nsv896120 CNV Loss 21882294
nsv896122 CNV Loss 21882294
nsv832030 CNV Loss 17160897
nsv896126 CNV Loss 21882294
dgv839n71 CNV Loss 21882294
dgv841n71 CNV Loss 21882294
dgv842n71 CNV Loss 21882294
nsv825652 CNV Gain 20364138
nsv896140 CNV Loss 21882294
nsv896141 CNV Loss 21882294
dgv843n71 CNV Loss 21882294
esv2743628 CNV Deletion 23290073
esv21677 CNV Loss 19812545
dgv134e201 CNV Deletion 23290073
esv1008205 CNV Deletion 20482838
dgv844n71 CNV Loss 21882294
esv1577545 CNV Deletion 17803354
esv1089089 CNV Deletion 17803354
esv2743632 CNV Deletion 23290073
esv2743633 CNV Deletion 23290073
esv2743634 CNV Deletion 23290073
esv2743635 CNV Deletion 23290073

Variation tolerance for DPYSL4 Gene

Residual Variation Intolerance Score: 4.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPYSL4 Gene

HapMap Linkage Disequilibrium report
DPYSL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL4 Gene

Disorders for DPYSL4 Gene

Relevant External Links for DPYSL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPYSL4
genes like me logo Genes that share disorders with DPYSL4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPYSL4 Gene

Publications for DPYSL4 Gene

  1. Characterization of the role of full-length CRMP3 and its calpain-cleaved product in inhibiting microtubule polymerization and neurite outgrowth. (PMID: 19559021) Aylsworth A. … Hou S.T. (Exp. Cell Res. 2009) 23 67
  2. Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia. (PMID: 16495451) Hou S.T. … Kappler J. (J. Neurosci. 2006) 23 67
  3. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma- related autoimmunity. (PMID: 11220734) Yu Z. … Lennon V.A. (Ann. Neurol. 2001) 23 67
  4. Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system. (PMID: 10664068) Inagaki H. … Eimoto T. (Histochem. Cell Biol. 2000) 23 67
  5. The Ulip family phosphoproteins -- common and specific properties. (PMID: 9652388) Byk T. … Sobel A. (Eur. J. Biochem. 1998) 2 67

Products for DPYSL4 Gene

Sources for DPYSL4 Gene

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