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Aliases for DPYSL4 Gene

Aliases for DPYSL4 Gene

  • Dihydropyrimidinase Like 4 2 3 5
  • Collapsin Response Mediator Protein 3 3 4
  • UNC33-Like Phosphoprotein 4 3 4
  • CRMP-3 3 4
  • ULIP-4 3 4
  • CRMP3 3 4
  • DRP-4 3 4
  • ULIP4 3 4
  • Dihydropyrimidinase-Related Protein 4 3
  • Dihydropyrimidinase-Like 4 2

External Ids for DPYSL4 Gene

Previous GeneCards Identifiers for DPYSL4 Gene

  • GC10P132911
  • GC10P133133
  • GC10P133877
  • GC10P133434
  • GC10P133850
  • GC10P134000
  • GC10P127552

Summaries for DPYSL4 Gene

GeneCards Summary for DPYSL4 Gene

DPYSL4 (Dihydropyrimidinase Like 4) is a Protein Coding gene. Among its related pathways are Semaphorin interactions and Developmental Biology. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL2.

UniProtKB/Swiss-Prot for DPYSL4 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Wiki entry for DPYSL4 Gene

Additional gene information for DPYSL4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL4 Gene

Genomics for DPYSL4 Gene

Regulatory Elements for DPYSL4 Gene

Enhancers for DPYSL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H132160 1.1 Ensembl ENCODE 43 -22.6 -22565 3 HDGF CTCF PKNOX1 KLF1 SIN3A KLF17 ZBTB7B E2F1 GATA3 CTBP1 DPYSL4 JAKMIP3
GH10H132175 0.8 Ensembl 57.1 -8.6 -8633 0 SOX13 MXI1 KLF1 FOXA2 KLF17 FEZF1 ZIC2 GLIS2 ZBTB48 ZNF600 DPYSL4 BNIP3 JAKMIP3
GH10H132158 0.8 Ensembl ENCODE 42 -25.6 -25625 2 MAZ SP3 GLIS1 PATZ1 TCF7L2 DPYSL4 JAKMIP3
GH10H132185 0.8 ENCODE 35.5 +0.8 765 0 KLF1 SAP130 SUZ12 ARID4B SIN3A ZIC2 GLIS2 CTBP1 EGR1 EGR2 DPYSL4 LOC105378567
GH10H132223 1.2 Ensembl ENCODE 22.9 +38.3 38314 0 ELF3 RB1 ARID4B ZNF76 KLF17 SIN3A DMAP1 ZNF2 RAD21 ZNF121 DPYSL4 LOC105378567 GC10M132318
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPYSL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPYSL4 Gene

Chromosome:
10
Start:
132,184,987 bp from pter
End:
132,205,776 bp from pter
Size:
20,790 bases
Orientation:
Plus strand

Genomic View for DPYSL4 Gene

Genes around DPYSL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL4 Gene

Proteins for DPYSL4 Gene

  • Protein details for DPYSL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14531-DPYL4_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 4
    Protein Accession:
    O14531
    Secondary Accessions:
    • B2RMQ1
    • D3DRG5
    • O00240
    • Q5T0Q7

    Protein attributes for DPYSL4 Gene

    Size:
    572 amino acids
    Molecular mass:
    61878 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By similarity).

neXtProt entry for DPYSL4 Gene

Post-translational modifications for DPYSL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL4 Gene

No data available for DME Specific Peptides for DPYSL4 Gene

Domains & Families for DPYSL4 Gene

Gene Families for DPYSL4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DPYSL4 Gene

Graphical View of Domain Structure for InterPro Entry

O14531

UniProtKB/Swiss-Prot:

DPYL4_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with DPYSL4: view

Function for DPYSL4 Gene

Molecular function for DPYSL4 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Phenotypes From GWAS Catalog for DPYSL4 Gene

Gene Ontology (GO) - Molecular Function for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0031005 filamin binding IPI 25358863
genes like me logo Genes that share ontologies with DPYSL4: view
genes like me logo Genes that share phenotypes with DPYSL4: view

Animal Models for DPYSL4 Gene

MGI Knock Outs for DPYSL4:

Animal Model Products

  • Taconic Biosciences Mouse Models for DPYSL4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DPYSL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPYSL4 Gene

Localization for DPYSL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYSL4 gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DPYSL4: view

Pathways & Interactions for DPYSL4 Gene

genes like me logo Genes that share pathways with DPYSL4: view

Pathways by source for DPYSL4 Gene

Gene Ontology (GO) - Biological Process for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9652388
GO:0070997 neuron death IEA --
GO:0097485 neuron projection guidance IEA --
genes like me logo Genes that share ontologies with DPYSL4: view

No data available for SIGNOR curated interactions for DPYSL4 Gene

Drugs & Compounds for DPYSL4 Gene

No Compound Related Data Available

Transcripts for DPYSL4 Gene

Unigene Clusters for DPYSL4 Gene

Dihydropyrimidinase-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DPYSL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3:

Relevant External Links for DPYSL4 Gene

GeneLoc Exon Structure for
DPYSL4
ECgene alternative splicing isoforms for
DPYSL4

Expression for DPYSL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPYSL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL4 Gene

This gene is overexpressed in Brain - Cortex (x4.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for DPYSL4 Gene

This gene is overexpressed in Brain (33.6), Fetal Brain (14.9), and Retina (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPYSL4 Gene



Protein tissue co-expression partners for DPYSL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPYSL4 Gene:

DPYSL4

SOURCE GeneReport for Unigene cluster for DPYSL4 Gene:

Hs.100058

Evidence on tissue expression from TISSUES for DPYSL4 Gene

  • Nervous system(4.7)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with DPYSL4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYSL4 Gene

Orthologs for DPYSL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPYSL4 33 34
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia DPYSL4 33 34
  • 87.49 (n)
mouse
(Mus musculus)
Mammalia Dpysl4 33 16 34
  • 86.31 (n)
cow
(Bos Taurus)
Mammalia DPYSL4 33 34
  • 86.25 (n)
rat
(Rattus norvegicus)
Mammalia Dpysl4 33
  • 86.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL4 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPYSL4 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPYSL4 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL4 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl4 33
  • 71.97 (n)
zebrafish
(Danio rerio)
Actinopterygii dpysl4 34
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CRMP 35
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-1 35
  • 48 (a)
dhp-2 35
  • 47 (a)
unc-33 35
  • 34 (a)
Species where no ortholog for DPYSL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL4 Gene

ENSEMBL:
Gene Tree for DPYSL4 (if available)
TreeFam:
Gene Tree for DPYSL4 (if available)

Paralogs for DPYSL4 Gene

Paralogs for DPYSL4 Gene

(5) SIMAP similar genes for DPYSL4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DPYSL4: view

Variants for DPYSL4 Gene

Sequence variations from dbSNP and Humsavar for DPYSL4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000082329 -- 132,188,867(+) CCTAG(A/G)GCTGT intron-variant, utr-variant-5-prime
rs1000120555 -- 132,183,286(+) CCTCC(C/T)CTGGG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000128060 -- 132,204,303(+) CCAAG(C/T)GTGAG intron-variant
rs1000160771 -- 132,204,551(+) GCAGG(C/G)ACGAG intron-variant
rs1000318235 -- 132,201,040(+) GATTG(C/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL4 Gene

Variant ID Type Subtype PubMed ID
dgv115e201 CNV deletion 23290073
esv1008205 CNV deletion 20482838
esv1089089 CNV deletion 17803354
esv1577545 CNV deletion 17803354
esv21677 CNV loss 19812545
esv2743628 CNV deletion 23290073
esv2743632 CNV deletion 23290073
esv2743633 CNV deletion 23290073
esv2743634 CNV deletion 23290073
esv2743635 CNV deletion 23290073
esv2761642 CNV gain 21179565
esv3624956 CNV gain 21293372
nsv1054569 CNV gain 25217958
nsv1054934 CNV gain 25217958
nsv1069524 CNV deletion 25765185
nsv1143525 CNV deletion 24896259
nsv552502 CNV loss 21841781
nsv552504 CNV loss 21841781
nsv825652 CNV gain 20364138
nsv832030 CNV loss 17160897
nsv951885 CNV deletion 24416366

Variation tolerance for DPYSL4 Gene

Residual Variation Intolerance Score: 4.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPYSL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPYSL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL4 Gene

Disorders for DPYSL4 Gene

Relevant External Links for DPYSL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPYSL4

No disorders were found for DPYSL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPYSL4 Gene

Publications for DPYSL4 Gene

  1. The Ulip family phosphoproteins--common and specific properties. (PMID: 9652388) Byk T … Sobel A (European journal of biochemistry 1998) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  3. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N … Nonaka M (Gene 1996) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for DPYSL4 Gene

Sources for DPYSL4 Gene

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