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Aliases for DPYSL3 Gene

Aliases for DPYSL3 Gene

  • Dihydropyrimidinase Like 3 2 3 5
  • Unc-33-Like Phosphoprotein 1 3 4
  • Dihydropyrimidinase-Like 3 2 3
  • CRMP-4 3 4
  • ULIP-1 3 4
  • CRMP4 3 4
  • DRP-3 3 4
  • DRP3 3 4
  • ULIP 3 4
  • Collapsin Response Mediator Protein 4 Long 3
  • Collapsin Response Mediator Protein 4 4
  • Testicular Secretory Protein Li 7 3
  • LCRMP 3
  • ULIP1 4

External Ids for DPYSL3 Gene

Previous GeneCards Identifiers for DPYSL3 Gene

  • GC05M146798
  • GC05M147352
  • GC05M146750
  • GC05M141917

Summaries for DPYSL3 Gene

GeneCards Summary for DPYSL3 Gene

DPYSL3 (Dihydropyrimidinase Like 3) is a Protein Coding gene. Diseases associated with DPYSL3 include Subependymal Glioma. Among its related pathways are Developmental Biology and Semaphorin interactions. GO annotations related to this gene include hydrolase activity and phosphoprotein binding. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot for DPYSL3 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Wiki entry for DPYSL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL3 Gene

Genomics for DPYSL3 Gene

Regulatory Elements for DPYSL3 Gene

Enhancers for DPYSL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPYSL3 on UCSC Golden Path with GeneCards custom track

Promoters for DPYSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPYSL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPYSL3 Gene

Chromosome:
5
Start:
147,390,808 bp from pter
End:
147,510,260 bp from pter
Size:
119,453 bases
Orientation:
Minus strand

Genomic View for DPYSL3 Gene

Genes around DPYSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL3 Gene

Proteins for DPYSL3 Gene

  • Protein details for DPYSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14195-DPYL3_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 3
    Protein Accession:
    Q14195
    Secondary Accessions:
    • B3SXQ8
    • Q93012

    Protein attributes for DPYSL3 Gene

    Size:
    570 amino acids
    Molecular mass:
    61963 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.

    Three dimensional structures from OCA and Proteopedia for DPYSL3 Gene

    Alternative splice isoforms for DPYSL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPYSL3 Gene

Proteomics data for DPYSL3 Gene at MOPED

Post-translational modifications for DPYSL3 Gene

  • Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL3 Gene

No data available for DME Specific Peptides for DPYSL3 Gene

Domains & Families for DPYSL3 Gene

Suggested Antigen Peptide Sequences for DPYSL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14195

UniProtKB/Swiss-Prot:

DPYL3_HUMAN :
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with DPYSL3: view

No data available for Gene Families for DPYSL3 Gene

Function for DPYSL3 Gene

Molecular function for DPYSL3 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0017124 SH3 domain binding IEA,ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Phenotypes for DPYSL3 Gene

genes like me logo Genes that share phenotypes with DPYSL3: view

Animal Models for DPYSL3 Gene

MGI Knock Outs for DPYSL3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPYSL3 Gene

Localization for DPYSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL3 Gene

Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPYSL3 Gene COMPARTMENTS Subcellular localization image for DPYSL3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070382 colocalizes_with exocytic vesicle IEA,ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Pathways & Interactions for DPYSL3 Gene

genes like me logo Genes that share pathways with DPYSL3: view

Pathways by source for DPYSL3 Gene

SIGNOR curated interactions for DPYSL3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010975 regulation of neuron projection development IEA --
GO:0030334 regulation of cell migration IEA --
GO:0030336 negative regulation of cell migration IEA,ISS --
GO:0048678 response to axon injury IEA,ISS --
GO:0051017 actin filament bundle assembly IEA,ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Drugs & Compounds for DPYSL3 Gene

(1) Drugs for DPYSL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DPYSL3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ureidopropionic acid
  • 3-(Carbamoylamino)propanoate
  • 3-(Carbamoylamino)propanoic acid
  • 3-Ureido-propionate
  • 3-Ureidopropanoate
  • 3-Ureidopropanoic acid
462-88-4
genes like me logo Genes that share compounds with DPYSL3: view

Transcripts for DPYSL3 Gene

Unigene Clusters for DPYSL3 Gene

Dihydropyrimidinase-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL3 Gene

No ASD Table

Relevant External Links for DPYSL3 Gene

GeneLoc Exon Structure for
DPYSL3
ECgene alternative splicing isoforms for
DPYSL3

Expression for DPYSL3 Gene

mRNA expression in normal human tissues for DPYSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL3 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.4).

Protein differential expression in normal tissues from HIPED for DPYSL3 Gene

This gene is overexpressed in Fetal Brain (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPYSL3 Gene



SOURCE GeneReport for Unigene cluster for DPYSL3 Gene Hs.519659

mRNA Expression by UniProt/SwissProt for DPYSL3 Gene

Q14195-DPYL3_HUMAN
Tissue specificity: Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
genes like me logo Genes that share expression patterns with DPYSL3: view

Protein tissue co-expression partners for DPYSL3 Gene

- Elite partner

Primer Products

Orthologs for DPYSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPYSL3 35
  • 91.33 (n)
  • 97.95 (a)
DPYSL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPYSL3 35
  • 90.85 (n)
  • 98.22 (a)
DPYSL3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpysl3 35
  • 90.43 (n)
  • 97.86 (a)
Dpysl3 16
Dpysl3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPYSL3 35
  • 99.11 (n)
  • 99.47 (a)
DPYSL3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpysl3 35
  • 90.67 (n)
  • 98.04 (a)
oppossum
(Monodelphis domestica)
Mammalia DPYSL3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL3 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPYSL3 35
  • 81.7 (n)
  • 91.44 (a)
DPYSL3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl3 35
  • 79.26 (n)
  • 90.37 (a)
Str.2981 35
African clawed frog
(Xenopus laevis)
Amphibia dpysl3-prov 35
zebrafish
(Danio rerio)
Actinopterygii dpysl3 35
  • 73.89 (n)
  • 81 (a)
Dr.18061 35
dpysl3 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CRMP 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-1 37
  • 47 (a)
dhp-2 37
  • 50 (a)
unc-33 37
  • 32 (a)
Species with no ortholog for DPYSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL3 Gene

ENSEMBL:
Gene Tree for DPYSL3 (if available)
TreeFam:
Gene Tree for DPYSL3 (if available)

Paralogs for DPYSL3 Gene

Paralogs for DPYSL3 Gene

(5) SIMAP similar genes for DPYSL3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DPYSL3: view

Variants for DPYSL3 Gene

Sequence variations from dbSNP and Humsavar for DPYSL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_020485 -
rs726054 -- 147,488,137(-) GGGCT(G/T)TTTTC intron-variant
rs891947 -- 147,404,822(-) TGAGT(A/G)GGTCT intron-variant
rs930213 -- 147,483,290(-) TAAAA(A/G)TACCT intron-variant
rs958677 -- 147,482,666(-) TGCTT(G/T)GATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL3 Gene

Variant ID Type Subtype PubMed ID
nsv519847 CNV Gain+Loss 19592680
nsv5055 CNV Loss 18451855
esv27495 CNV Loss 19812545
esv2678822 CNV Deletion 23128226
esv992285 CNV Deletion 20482838

Variation tolerance for DPYSL3 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPYSL3 Gene

Human Gene Mutation Database (HGMD)
DPYSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL3 Gene

Disorders for DPYSL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPYSL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subependymal glioma
  • mixed subependymoma-ependymoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DPYSL3

Genetic Association Database (GAD)
DPYSL3
Human Genome Epidemiology (HuGE) Navigator
DPYSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPYSL3
genes like me logo Genes that share disorders with DPYSL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL3 Gene

Publications for DPYSL3 Gene

  1. Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. (PMID: 9115293) Gaetano C. … Thiele C.J. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N. … Nonaka M. (Gene 1996) 2 3 23
  3. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. (PMID: 16611631) Cole A.R. … Sutherland C. (J. Biol. Chem. 2006) 3 23
  4. HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. (PMID: 15933812) Choi Y.L. … Thiele C.J. (J. Neurooncol. 2005) 3 23
  5. Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts. (PMID: 10748015) Matsuo T. … Thiele C.J. (J. Biol. Chem. 2000) 3 23

Products for DPYSL3 Gene

Sources for DPYSL3 Gene

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