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DPYSL3 Gene

protein-coding   GIFtS: 61
GCID: GC05M146750

Dihydropyrimidinase-Like 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dihydropyrimidinase-Like 31 2     ULIP-12 3
DRP32 3 5     LCRMP2
ULIP2 3 5     Collapsin Response Mediator Protein 4 Long2
Unc-33-Like Phosphoprotein 12 3     Dihydropyrimidinase-Related Protein 32
CRMP-42 3     ULIP13
CRMP42 3     Collapsin Response Mediator Protein 43
DRP-32 3     

External Ids:    HGNC: 30151   Entrez Gene: 18092   Ensembl: ENSG000001136577   OMIM: 6011685   UniProtKB: Q141953   

Export aliases for DPYSL3 gene to outside databases

Previous GC identifers: GC05M146798 GC05M147352 GC05M141917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DPYSL3 Gene:
DPYSL3 (dihydropyrimidinase-like 3) is a protein-coding gene. Diseases associated with DPYSL3 include 5q- syndrome, and amyotrophic lateral sclerosis. GO annotations related to this gene include SH3 domain binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot: DPYL3_HUMAN, Q14195
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)

Gene Wiki entry for DPYSL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPYSL3 gene promoter:
         AML1a   Pbx1a   E4BP4   HNF-1A   Evi-1   Sox9   FOXO1a   Cart-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DPYSL3 promoter sequence
   Search Chromatin IP Primers for DPYSL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPYSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

DPYSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPYSL3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M146750:  view genomic region     (about GC identifiers)

Start:
146,770,371 bp from pter      End:
146,889,619 bp from pter
Size:
119,249 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DPYL3_HUMAN, Q14195 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 3  
Size: 570 amino acids; 61963 Da
Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with
synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
1 PDB 3D structure from and Proteopedia for DPYSL3:
4BKN (3D)    
Secondary accessions: B3SXQ8 Q93012
Alternative splicing: 2 isoforms:  Q14195-1   Q14195-2   (Contains a phosphoserine at position 102)

Explore the universe of human proteins at neXtProt for DPYSL3: NX_Q14195

Explore proteomics data for DPYSL3 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK31
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DPYSL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001184223.1  NP_001378.1  

    ENSEMBL proteins: 
     ENSP00000381526   ENSP00000343690   ENSP00000430267   ENSP00000428958   ENSP00000426720  
     ENSP00000441819  
    Reactome Protein details: Q14195

    DPYSL3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR006680 Amidohydro_1
     IPR011059 Metal-dep_hydrolase_composite

    Graphical View of Domain Structure for InterPro Entry Q14195

    ProtoNet protein and cluster: Q14195

    2 Blocks protein domains:
    IPB005847 Dihydroorotase region
    IPB011550 Amidohydrolase-like


    UniProtKB/Swiss-Prot: DPYL3_HUMAN, Q14195
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    DPYSL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPYL3_HUMAN, Q14195
    Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a
    role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--
    GO:0017124SH3 domain binding ISS--
    GO:0035374chondroitin sulfate binding ISS--
         
    DPYSL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPYSL3
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    miRNA
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    miRTarBase miRNAs that target DPYSL3:
    hsa-mir-423-3p (MIRT042483), hsa-mir-197-3p (MIRT004195), hsa-mir-375 (MIRT020059), hsa-mir-26b-5p (MIRT030031)

    Block miRNA regulation of human, mouse, rat DPYSL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPYSL3 (see all 72):
    hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-632 hsa-miR-4315 hsa-miR-1304 hsa-miR-29a* hsa-miR-647
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPYSL3

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for DPYSL3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPYL3_HUMAN, Q14195: Cytoplasm (By similarity). Cell projection, growth cone (By similarity). Note=Colocalizes
    with synaptic vesicle protein 2 in the central region of the growth cone (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    extracellular4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0030027lamellipodium ISS--
    GO:0030426growth cone ISS--

    DPYSL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DPYSL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1superpathway of pyrimidine ribonucleosides degradation
    superpathway of pyrimidine ribonucleosides degradation0.60
    uracil degradation I (reductive)0.00
    thymine degradation0.60
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Semaphorin interactions
    Semaphorin interactions0.43
    CRMPs in Sema3A signaling0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for DPYSL3
        uracil degradation I (reductive)
    thymine degradation
    superpathway of pyrimidine ribonucleosides degradation


    1 Reactome Pathway for DPYSL3
        CRMPs in Sema3A signaling



    DPYSL3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPYSL3
    Interactions:

        GeneGlobe Interaction Network for DPYSL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DPYSL3 (Q141953 ENSP000003815264) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    DPYSL5Q9BPU63, ENSP000002886994I2D: score=1 STRING: ENSP00000288699
    HTTP428583, ENSP000003471844I2D: score=1 STRING: ENSP00000347184
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    SLC2A4P146723I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007399nervous system development ----
    GO:0007411axon guidance TAS--
    GO:0010976positive regulation of neuron projection development ISS--
    GO:0010977negative regulation of neuron projection development ISS--

    DPYSL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPYSL3 (DPYL3)

    1 HMDB Compound for DPYSL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ureidopropionic acid3-Ureido-propionate (see all 20)462-88-4--

    2 Novoseek inferred chemical compound relationships for DPYSL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 26.2 1 9115293 (1)
    nmda 19 19 16987501 (7), 16135096 (3)



    DPYSL3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DPYSL3 gene (2 alternative transcripts): 
    NM_001197294.1  NM_001387.2  

    Unigene Cluster for DPYSL3:

    Dihydropyrimidinase-like 3
    Hs.519659  [show with all ESTs]
    Unigene Representative Sequence: NM_001197294
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398514(uc003lon.1) ENST00000343218(uc003loo.3) ENST00000520473
    ENST00000507309 ENST00000523458 ENST00000508042 ENST00000519672 ENST00000512722
    ENST00000504965 ENST00000534907
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DPYSL3 (see all 72):
    hsa-miR-323-3p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-632 hsa-miR-4315 hsa-miR-1304 hsa-miR-29a* hsa-miR-647
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    Additional mRNA sequence: 

    AK297223.1 BC039006.1 BC077077.1 D78014.1 EU007906.1 Y07818.1 

    21 DOTS entries:

    DT.452514  DT.100663178  DT.120818077  DT.120818078  DT.95243942  DT.100038223  DT.92460185  DT.40115531 
    DT.101978926  DT.120818033  DT.95364680  DT.100038224  DT.100703651  DT.100804219  DT.100804220  DT.120818051 
    DT.120818075  DT.97787916  DT.87079462  DT.95098676  DT.95098685 

    Selected AceView cDNA sequences (see all 585):

    BF057311 BU726045 BM693502 AI971882 AI150716 T33773 BQ183592 AA464931 
    BQ427728 AU143157 CD245368 AL536926 CA439586 AI393707 AW090775 BF432410 
    AA096219 BF508959 BQ614163 CB530004 CB306056 BQ897262 T35347 BM713993 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPYSL3 expression in normal human tissues (normalized intensities)      DPYSL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGCCCTG
    DPYSL3 Expression
    About this image


    DPYSL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cushion Mesenchymal Cells Endocardium
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     NULL (Uncategorized)
             Neural rosettes
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    DPYSL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPYSL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519659

    UniProtKB/Swiss-Prot: DPYL3_HUMAN, Q14195
    Tissue specificity: Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and
    spinal cord

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DPYSL3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpysl31 , 5 dihydropyrimidinase-like 31, 5 90.43(n)1
    97.86(a)1
      18 (23.25 cM)5
    222401  NM_009468.41  NP_033494.11 
     433209795 
    chicken
    (Gallus gallus)
    Aves DPYSL31 dihydropyrimidinase-like 3 81.7(n)
    91.44(a)
      395154  NM_204493.1  NP_989824.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPYSL36
    dihydropyrimidinase-like 3
    88(a)
    1 ↔ 1
    2(137384944-137471118)
    African clawed frog
    (Xenopus laevis)
    Amphibia dpysl3-prov2 dihydropyrimidinase-like 3 76.28(n)    BC046836.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.180612 Transcribed sequence with moderate similarity to protein more 82.93(n)    AL717500.1 


    ENSEMBL Gene Tree for DPYSL3 (if available)
    TreeFam Gene Tree for DPYSL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPYSL3 gene
    CRMP12  DPYSL42  DPYSL52  DPYS2  DPYSL22  
    5 SIMAP similar genes for DPYSL3 using alignment to 7 protein entries:     DPYL3_HUMAN (see all proteins):
    DPYSL2    CRMP1    DPYSL4    DPYSL5    DPYS

    DPYSL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPYSL3 (see all 2422)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382380621,2
    --146769896(+) CCGTAC/TACTGA 2 -- int10--------
    rs623795701,2
    --146770040(+) AAAGAC/ACAAAA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs600673441,2
    C--146770057(+) AAAAA-/A/CCCCAA 2 -- int10--------
    rs1144085261,2
    F--146770129(+) ACTAAA/GTTTGA 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1878416961,2
    --146770190(+) CATCAA/CGCTTG 2 -- int10--------
    rs1125244501,2
    C--146770208(+) AAACTA/GACAAC 2 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs171066201,2
    C,F--146770359(+) AAGACT/CGGAGA 2 -- int15Minor allele frequency- C:0.07NA WA 262
    rs1913185091,2
    C--146770473(+) GTTCAC/TGGTTC 2 -- ut310--------
    rs759821201,2
    C,F--146770498(+) TTCACG/ATTCCA 2 -- ut311Minor allele frequency- A:0.11WA 118
    rs1169344751,2
    F--146770613(+) CAATGA/TATGCT 2 -- ut311Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for DPYSL3 (146770371 - 146889619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DPYSL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678822CNV Deletion23128226
    esv992285CNV Deletion20482838
    esv27495CNV Loss19812545
    nsv5055CNV Loss18451855
    nsv519847CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): DPYSL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPYSL3
    DNA2.0 Custom Variant and Variant Library Synthesis for DPYSL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601168    OMIM disorders: --

    16 diseases for DPYSL3:    About MalaCards
    5q- syndrome    amyotrophic lateral sclerosis    endocarditis    medulloblastoma
    down syndrome    neuroblastoma    schizophrenia    hypoxia
    tuberculosis    cervicitis    retinitis    lung cancer
    prostate cancer    prostatitis    neuronitis    cerebritis


    DPYSL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DPYSL3
    Human Genome Epidemiology (HuGE) Navigator: DPYSL3 (1 document)

    Export disorders for DPYSL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPYSL3 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with DPYSL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. (PubMed id 9115293)1, 2, 3, 9 Gaetano C.... Thiele C.J. (J. Biol. Chem. 1997)
    2. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 2, 3, 9 Hamajima N.... Nonaka M. (Gene 1996)
    3. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. (PubMed id 16611631)1, 2, 9 Cole A.R.... Sutherland C. (J. Biol. Chem. 2006)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts. (PubMed id 10748015)1, 9 Matsuo T.... Thiele C.J. (J. Biol. Chem. 2000)
    7. HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. (PubMed id 15933812)1, 9 Choi Y.L....Thiele C.J. (J. Neurooncol. 2005)
    8. A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS. (PubMed id 23568759)1 Blasco H....Corcia P. (Hum. Mutat. 2013)
    9. Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma. (PubMed id 24011394)1 Tan F....Li Z. (Cancer Sci. 2013)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1809 HGNC: 3015 AceView: DPYSL3 Ensembl:ENSG00000113657 euGenes: HUgn1809
    ECgene: DPYSL3 H-InvDB: DPYSL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPYSL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DPYSL3 gene:
    Search GeneIP for patents involving DPYSL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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