Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DPYSL3 Gene

Aliases for DPYSL3 Gene

  • Dihydropyrimidinase-Like 3 2 3
  • DRP3 3 4 6
  • ULIP 3 4 6
  • Unc-33-Like Phosphoprotein 1 3 4
  • CRMP-4 3 4
  • ULIP-1 3 4
  • CRMP4 3 4
  • DRP-3 3 4
  • Collapsin Response Mediator Protein 4 Long 3
  • Dihydropyrimidinase-Related Protein 3 3
  • Collapsin Response Mediator Protein 4 4
  • LCRMP 3
  • ULIP1 4

External Ids for DPYSL3 Gene

Previous GeneCards Identifiers for DPYSL3 Gene

  • GC05M146798
  • GC05M147352
  • GC05M146750
  • GC05M141917

Summaries for DPYSL3 Gene

GeneCards Summary for DPYSL3 Gene

DPYSL3 (Dihydropyrimidinase-Like 3) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include SH3 domain binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot for DPYSL3 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Wiki entry for DPYSL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL3 Gene

Genomics for DPYSL3 Gene

Regulatory Elements for DPYSL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPYSL3 Gene

Start:
147,390,808 bp from pter
End:
147,510,056 bp from pter
Size:
119,249 bases
Orientation:
Minus strand

Genomic View for DPYSL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPYSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL3 Gene

Proteins for DPYSL3 Gene

  • Protein details for DPYSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14195-DPYL3_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 3
    Protein Accession:
    Q14195
    Secondary Accessions:
    • B3SXQ8
    • Q93012

    Protein attributes for DPYSL3 Gene

    Size:
    570 amino acids
    Molecular mass:
    61963 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.

    Three dimensional structures from OCA and Proteopedia for DPYSL3 Gene

    Alternative splice isoforms for DPYSL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPYSL3 Gene

Proteomics data for DPYSL3 Gene at MOPED

Post-translational modifications for DPYSL3 Gene

  • Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL3 Gene

Antibody Products

No data available for DME Specific Peptides for DPYSL3 Gene

Domains for DPYSL3 Gene

Suggested Antigen Peptide Sequences for DPYSL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14195

UniProtKB/Swiss-Prot:

DPYL3_HUMAN :
  • Q14195
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with DPYSL3: view

No data available for Gene Families for DPYSL3 Gene

Function for DPYSL3 Gene

Molecular function for DPYSL3 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides --
GO:0017124 SH3 domain binding ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Animal Model Products

miRNA for DPYSL3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPYSL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPYSL3 Gene

Localization for DPYSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL3 Gene

Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPYSL3 Gene COMPARTMENTS Subcellular localization image for DPYSL3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
extracellular 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0030027 lamellipodium ISS --
GO:0030426 growth cone ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Pathways for DPYSL3 Gene

genes like me logo Genes that share pathways with DPYSL3: view

Gene Ontology (GO) - Biological Process for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006208 pyrimidine nucleobase catabolic process --
GO:0007399 nervous system development --
GO:0007411 axon guidance TAS --
GO:0008152 metabolic process IEA --
GO:0010976 positive regulation of neuron projection development ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Compounds for DPYSL3 Gene

(1) HMDB Compounds for DPYSL3 Gene

Compound Synonyms Cas Number PubMed IDs
Ureidopropionic acid
  • 3-Ureido-propionate
462-88-4

(2) Novoseek inferred chemical compound relationships for DPYSL3 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 26.2 1
nmda 19 10
genes like me logo Genes that share compounds with DPYSL3: view

Transcripts for DPYSL3 Gene

Unigene Clusters for DPYSL3 Gene

Dihydropyrimidinase-like 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPYSL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL3 Gene

No ASD Table

Relevant External Links for DPYSL3 Gene

GeneLoc Exon Structure for
DPYSL3
ECgene alternative splicing isoforms for
DPYSL3

Expression for DPYSL3 Gene

mRNA expression in normal human tissues for DPYSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL3 Gene

This gene is overexpressed in Esophagus - Muscularis (4.4).

Protein differential expression in normal tissues for DPYSL3 Gene

This gene is overexpressed in Fetal Brain (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPYSL3 Gene

SOURCE GeneReport for Unigene cluster for DPYSL3 Gene Hs.519659

mRNA Expression by UniProt/SwissProt for DPYSL3 Gene

Q14195-DPYL3_HUMAN
Tissue specificity: Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord
genes like me logo Genes that share expressions with DPYSL3: view

Expression partners for DPYSL3 Gene

In Situ Assay Products

Orthologs for DPYSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPYSL3 35
  • 91.33 (n)
  • 97.95 (a)
DPYSL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPYSL3 35
  • 90.85 (n)
  • 98.22 (a)
DPYSL3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpysl3 35
  • 90.43 (n)
  • 97.86 (a)
Dpysl3 16
Dpysl3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPYSL3 35
  • 99.11 (n)
  • 99.47 (a)
DPYSL3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpysl3 35
  • 90.67 (n)
  • 98.04 (a)
oppossum
(Monodelphis domestica)
Mammalia DPYSL3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL3 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPYSL3 35
  • 81.7 (n)
  • 91.44 (a)
DPYSL3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl3 35
  • 79.26 (n)
  • 90.37 (a)
Str.2981 35
African clawed frog
(Xenopus laevis)
Amphibia dpysl3-prov 35
zebrafish
(Danio rerio)
Actinopterygii dpysl3 35
  • 73.89 (n)
  • 81 (a)
Dr.18061 35
dpysl3 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CRMP 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-1 37
  • 47 (a)
dhp-2 37
  • 50 (a)
unc-33 37
  • 32 (a)
Species with no ortholog for DPYSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL3 Gene

ENSEMBL:
Gene Tree for DPYSL3 (if available)
TreeFam:
Gene Tree for DPYSL3 (if available)

Paralogs for DPYSL3 Gene

Paralogs for DPYSL3 Gene

Selected SIMAP similar genes for DPYSL3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DPYSL3: view

Variants for DPYSL3 Gene

Sequence variations from dbSNP and Humsavar for DPYSL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs13002 -- 147,391,182(-) ACTCA(C/T)CCCTG utr-variant-3-prime
rs13495 -- 147,391,064(-) TGCCC(C/T)GGGCA utr-variant-3-prime
rs645983 -- 147,421,795(+) gaaaa(C/T)tggct intron-variant
rs726054 -- 147,488,137(-) GGGCT(G/T)TTTTC intron-variant
rs891947 -- 147,404,822(-) TGAGT(A/G)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL3 Gene

Variant ID Type Subtype PubMed ID
nsv519847 CNV Gain+Loss 19592680
nsv5055 CNV Loss 18451855
esv27495 CNV Loss 19812545
esv2678822 CNV Deletion 23128226
esv992285 CNV Deletion 20482838

Relevant External Links for DPYSL3 Gene

HapMap Linkage Disequilibrium report
DPYSL3
Human Gene Mutation Database (HGMD)
DPYSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL3 Gene

Disorders for DPYSL3 Gene

Relevant External Links for DPYSL3

Genetic Association Database (GAD)
DPYSL3
Human Genome Epidemiology (HuGE) Navigator
DPYSL3

No disorders were found for DPYSL3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DPYSL3 Gene

Publications for DPYSL3 Gene

  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N. … Nonaka M. (Gene 1996) 2 3 4 23
  2. Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. (PMID: 9115293) Gaetano C. … Thiele C.J. (J. Biol. Chem. 1997) 2 3 4 23
  3. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. (PMID: 16611631) Cole A.R. … Sutherland C. (J. Biol. Chem. 2006) 3 4 23
  4. HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors. (PMID: 15933812) Choi Y.L. … Thiele C.J. (J. Neurooncol. 2005) 3 23
  5. Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts. (PMID: 10748015) Matsuo T. … Thiele C.J. (J. Biol. Chem. 2000) 3 23

Products for DPYSL3 Gene

Sources for DPYSL3 Gene

Back to Top

Content