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Aliases for DPYSL3 Gene

Aliases for DPYSL3 Gene

  • Dihydropyrimidinase Like 3 2 3 5
  • Unc-33-Like Phosphoprotein 1 3 4
  • CRMP-4 3 4
  • ULIP-1 3 4
  • CRMP4 3 4
  • DRP-3 3 4
  • DRP3 3 4
  • ULIP 3 4
  • Collapsin Response Mediator Protein 4 Long 3
  • Dihydropyrimidinase-Related Protein 3 3
  • Collapsin Response Mediator Protein 4 4
  • Testicular Secretory Protein Li 7 3
  • Dihydropyrimidinase-Like 3 2
  • LCRMP 3
  • ULIP1 4

External Ids for DPYSL3 Gene

Previous GeneCards Identifiers for DPYSL3 Gene

  • GC05M146798
  • GC05M147352
  • GC05M146750
  • GC05M141917

Summaries for DPYSL3 Gene

GeneCards Summary for DPYSL3 Gene

DPYSL3 (Dihydropyrimidinase Like 3) is a Protein Coding gene. Diseases associated with DPYSL3 include Cauda Equina Syndrome. Among its related pathways are Semaphorin interactions and Developmental Biology. GO annotations related to this gene include hydrolase activity and phosphoprotein binding. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot for DPYSL3 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Wiki entry for DPYSL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL3 Gene

Genomics for DPYSL3 Gene

Regulatory Elements for DPYSL3 Gene

Enhancers for DPYSL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F147451 1 FANTOM5 ENCODE 26.1 +56.3 56304 5.6 ZNF76 KLF17 ZNF2 RAD21 ZEB1 GLIS2 CBX5 SCRT2 ZNF143 KLF7 DPYSL3 LOC105378217 STK32A JAKMIP2 PPP2R2B GC05P147435
GH05F147534 1.5 FANTOM5 Ensembl ENCODE 14.3 -25.6 -25553 2.6 SP3 JUN SIN3A CEBPG ZEB1 JUND ZNF366 PRDM10 FOS SP7 DPYSL3 PIR44601
GH05F147465 1.4 Ensembl ENCODE 13.1 +43.8 43765 1.7 DPYSL3 GC05P147435
GH05F147464 0.2 ENCODE 13.1 +45.8 45838 0.2 CTCF SMC3 REST RAD21 DPYSL3 GC05P147435
GH05F147552 1.3 FANTOM5 Ensembl ENCODE 12.9 -44.1 -44082 3.6 JUND RFX1 HLF SIN3A DPYSL3 STK32A LOC105378217 JAKMIP2-AS1 PIR44601
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DPYSL3 on UCSC Golden Path with GeneCards custom track

Promoters for DPYSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001293153 1459 3200 SIN3A ZNF2 RAD21 GLIS2 SCRT2 FOS ZNF263 REST ZEB2 ZNF843

Genomic Location for DPYSL3 Gene

Chromosome:
5
Start:
147,390,808 bp from pter
End:
147,510,260 bp from pter
Size:
119,453 bases
Orientation:
Minus strand

Genomic View for DPYSL3 Gene

Genes around DPYSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL3 Gene

Proteins for DPYSL3 Gene

  • Protein details for DPYSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14195-DPYL3_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 3
    Protein Accession:
    Q14195
    Secondary Accessions:
    • B3SXQ8
    • Q93012

    Protein attributes for DPYSL3 Gene

    Size:
    570 amino acids
    Molecular mass:
    61963 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.

    Three dimensional structures from OCA and Proteopedia for DPYSL3 Gene

    Alternative splice isoforms for DPYSL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPYSL3 Gene

Post-translational modifications for DPYSL3 Gene

  • Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL3 Gene

No data available for DME Specific Peptides for DPYSL3 Gene

Domains & Families for DPYSL3 Gene

Suggested Antigen Peptide Sequences for DPYSL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14195

UniProtKB/Swiss-Prot:

DPYL3_HUMAN :
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with DPYSL3: view

No data available for Gene Families for DPYSL3 Gene

Function for DPYSL3 Gene

Molecular function for DPYSL3 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0017124 SH3 domain binding ISS --
GO:0031005 filamin binding IPI 25358863
genes like me logo Genes that share ontologies with DPYSL3: view

Phenotypes for DPYSL3 Gene

genes like me logo Genes that share phenotypes with DPYSL3: view

Animal Models for DPYSL3 Gene

MGI Knock Outs for DPYSL3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPYSL3 Gene

Localization for DPYSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL3 Gene

Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPYSL3 Gene COMPARTMENTS Subcellular localization image for DPYSL3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030027 lamellipodium ISS --
GO:0030426 growth cone ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Pathways & Interactions for DPYSL3 Gene

genes like me logo Genes that share pathways with DPYSL3: view

Pathways by source for DPYSL3 Gene

SIGNOR curated interactions for DPYSL3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010975 regulation of neuron projection development IEA --
GO:0010976 positive regulation of neuron projection development ISS --
GO:0010977 negative regulation of neuron projection development ISS --
GO:0030334 regulation of cell migration IEA --
GO:0030336 negative regulation of cell migration ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Drugs & Compounds for DPYSL3 Gene

(1) Drugs for DPYSL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DPYSL3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ureidopropionic acid
  • 3-(Carbamoylamino)propanoate
  • 3-(Carbamoylamino)propanoic acid
  • 3-Ureido-propionate
  • 3-Ureidopropanoate
  • 3-Ureidopropanoic acid
462-88-4
genes like me logo Genes that share compounds with DPYSL3: view

Transcripts for DPYSL3 Gene

Unigene Clusters for DPYSL3 Gene

Dihydropyrimidinase-like 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL3 Gene

No ASD Table

Relevant External Links for DPYSL3 Gene

GeneLoc Exon Structure for
DPYSL3
ECgene alternative splicing isoforms for
DPYSL3

Expression for DPYSL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPYSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL3 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.4).

Protein differential expression in normal tissues from HIPED for DPYSL3 Gene

This gene is overexpressed in Fetal Brain (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPYSL3 Gene



Protein tissue co-expression partners for DPYSL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPYSL3 Gene:

DPYSL3

SOURCE GeneReport for Unigene cluster for DPYSL3 Gene:

Hs.519659

mRNA Expression by UniProt/SwissProt for DPYSL3 Gene:

Q14195-DPYL3_HUMAN
Tissue specificity: Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
genes like me logo Genes that share expression patterns with DPYSL3: view

Primer Products

Orthologs for DPYSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPYSL3 34 35
  • 99.11 (n)
oppossum
(Monodelphis domestica)
Mammalia DPYSL3 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL3 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPYSL3 34 35
  • 91.33 (n)
dog
(Canis familiaris)
Mammalia DPYSL3 34 35
  • 90.85 (n)
rat
(Rattus norvegicus)
Mammalia Dpysl3 34
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Dpysl3 34 16 35
  • 90.43 (n)
chicken
(Gallus gallus)
Aves DPYSL3 34 35
  • 81.7 (n)
lizard
(Anolis carolinensis)
Reptilia DPYSL3 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl3 34
  • 79.26 (n)
Str.2981 34
African clawed frog
(Xenopus laevis)
Amphibia dpysl3-prov 34
zebrafish
(Danio rerio)
Actinopterygii dpysl3 34 35
  • 73.89 (n)
Dr.18061 34
fruit fly
(Drosophila melanogaster)
Insecta CRMP 36
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-2 36
  • 50 (a)
dhp-1 36
  • 47 (a)
unc-33 36
  • 32 (a)
Species where no ortholog for DPYSL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL3 Gene

ENSEMBL:
Gene Tree for DPYSL3 (if available)
TreeFam:
Gene Tree for DPYSL3 (if available)

Paralogs for DPYSL3 Gene

Paralogs for DPYSL3 Gene

(5) SIMAP similar genes for DPYSL3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DPYSL3: view

Variants for DPYSL3 Gene

Sequence variations from dbSNP and Humsavar for DPYSL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10041249 -- 147,453,516(+) CGAGC(A/G)AGGAG intron-variant
rs10042993 -- 147,396,150(+) GACAC(A/G)AGGTC intron-variant
rs10043932 -- 147,404,915(+) cagat(C/T)atatc intron-variant
rs10045916 -- 147,405,445(+) agtgg(A/G)AGAAA intron-variant
rs10052013 -- 147,398,686(+) GCACG(C/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL3 Gene

Variant ID Type Subtype PubMed ID
esv2678822 CNV deletion 23128226
esv27495 CNV loss 19812545
esv3607093 CNV loss 21293372
esv992285 CNV deletion 20482838
nsv1137034 CNV deletion 24896259
nsv5055 CNV deletion 18451855
nsv519847 CNV gain+loss 19592680
nsv599938 CNV gain 21841781

Variation tolerance for DPYSL3 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPYSL3 Gene

Human Gene Mutation Database (HGMD)
DPYSL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPYSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL3 Gene

Disorders for DPYSL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPYSL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cauda equina syndrome
  • polyradiculopathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DPYSL3

Genetic Association Database (GAD)
DPYSL3
Human Genome Epidemiology (HuGE) Navigator
DPYSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPYSL3
genes like me logo Genes that share disorders with DPYSL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL3 Gene

Publications for DPYSL3 Gene

  1. Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. (PMID: 9115293) Gaetano C. … Thiele C.J. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N. … Nonaka M. (Gene 1996) 2 3 4 22 64
  3. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. (PMID: 16611631) Cole A.R. … Sutherland C. (J. Biol. Chem. 2006) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for DPYSL3 Gene

Sources for DPYSL3 Gene

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