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Aliases for DPYSL2 Gene

Aliases for DPYSL2 Gene

  • Dihydropyrimidinase-Like 2 2 3
  • CRMP2 3 4 6
  • Unc-33-Like Phosphoprotein 2 3 4
  • CRMP-2 3 4
  • ULIP-2 3 4
  • DRP-2 3 4
  • ULIP2 3 4
  • DRP2 3 6
  • N2A3 3 4
  • Collapsin Response Mediator Protein HCRMP-2 3
  • Dihydropyrimidinase-Related Protein 2 3
  • Collapsin Response Mediator Protein 2 4
  • DHPRP2 3

External Ids for DPYSL2 Gene

Previous GeneCards Identifiers for DPYSL2 Gene

  • GC08P026208
  • GC08P026792
  • GC08P026457
  • GC08P026491
  • GC08P024980
  • GC08P026371

Summaries for DPYSL2 Gene

Entrez Gene Summary for DPYSL2 Gene

  • This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for DPYSL2 Gene

DPYSL2 (Dihydropyrimidinase-Like 2) is a Protein Coding gene. Diseases associated with DPYSL2 include schizophrenia. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include protein kinase binding and dihydropyrimidinase activity. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot for DPYSL2 Gene

  • Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Gene Wiki entry for DPYSL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL2 Gene

Genomics for DPYSL2 Gene

Regulatory Elements for DPYSL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPYSL2 Gene

26,514,193 bp from pter
26,658,178 bp from pter
143,986 bases
Plus strand

Genomic View for DPYSL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPYSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL2 Gene

Proteins for DPYSL2 Gene

  • Protein details for DPYSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dihydropyrimidinase-related protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K5H2
    • B4DR31
    • D3DSS7
    • O00424

    Protein attributes for DPYSL2 Gene

    572 amino acids
    Molecular mass:
    62294 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.

    Three dimensional structures from OCA and Proteopedia for DPYSL2 Gene

    Alternative splice isoforms for DPYSL2 Gene


neXtProt entry for DPYSL2 Gene

Proteomics data for DPYSL2 Gene at MOPED

Post-translational modifications for DPYSL2 Gene

  • 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
  • Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
  • Ubiquitination at Lys345 and Lys472
  • Modification sites at PhosphoSitePlus

Other Protein References for DPYSL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DPYSL2 (CRMP-2)

No data available for DME Specific Peptides for DPYSL2 Gene

Domains for DPYSL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q16555
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with DPYSL2: view

No data available for Gene Families for DPYSL2 Gene

Function for DPYSL2 Gene

Molecular function for DPYSL2 Gene

GENATLAS Biochemistry: dihydropyrimidinase related protein 2,mainly expressed in the fetal and neonatal brain,involved in the developmental process of the nervous system
UniProtKB/Swiss-Prot Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Gene Ontology (GO) - Molecular Function for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004157 dihydropyrimidinase activity TAS 8973361
GO:0005515 protein binding IPI 16260607
GO:0008017 microtubule binding IEA --
GO:0016787 hydrolase activity --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds --
genes like me logo Genes that share ontologies with DPYSL2: view

Phenotypes for DPYSL2 Gene

MGI mutant phenotypes for DPYSL2:
inferred from 1 alleles
GenomeRNAi human phenotypes for DPYSL2:
genes like me logo Genes that share phenotypes with DPYSL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPYSL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPYSL2 Gene

Localization for DPYSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL2 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes.

Subcellular locations from

Jensen Localization Image for DPYSL2 Gene COMPARTMENTS Subcellular localization image for DPYSL2 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005874 colocalizes_with microtubule IDA 20801876
GO:0016020 colocalizes_with membrane IDA 20801876
genes like me logo Genes that share ontologies with DPYSL2: view

Pathways for DPYSL2 Gene

genes like me logo Genes that share pathways with DPYSL2: view

Pathways by source for DPYSL2 Gene

1 KEGG pathway for DPYSL2 Gene

Gene Ontology (GO) - Biological Process for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 8973361
GO:0006208 pyrimidine nucleobase catabolic process --
GO:0006897 endocytosis IMP 20801876
GO:0007010 cytoskeleton organization ISS --
genes like me logo Genes that share ontologies with DPYSL2: view

Compounds for DPYSL2 Gene

(1) HMDB Compounds for DPYSL2 Gene

Compound Synonyms Cas Number PubMed IDs
Ureidopropionic acid
  • 3-Ureido-propionate

(5) Novoseek inferred chemical compound relationships for DPYSL2 Gene

Compound -log(P) Hits PubMed IDs
glyceraldehyde 3-phosphate 55.5 7
glycogen 49 7
glutamate 25.1 2
creatinine 7.63 2
phosphatidylinositol 1.25 2
genes like me logo Genes that share compounds with DPYSL2: view

Transcripts for DPYSL2 Gene

Unigene Clusters for DPYSL2 Gene

Dihydropyrimidinase-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPYSL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - -
SP2: -
SP4: - -
SP5: -
SP6: -

Relevant External Links for DPYSL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPYSL2 Gene

mRNA expression in normal human tissues for DPYSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPYSL2 Gene

SOURCE GeneReport for Unigene cluster for DPYSL2 Gene Hs.593187

mRNA Expression by UniProt/SwissProt for DPYSL2 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with DPYSL2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DPYSL2 Gene

Orthologs for DPYSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPYSL2 35
  • 99.36 (n)
  • 99.85 (a)
  • 100 (a)
(Bos Taurus)
Mammalia DPYSL2 35
  • 90.85 (n)
  • 98.06 (a)
  • 99 (a)
(Canis familiaris)
Mammalia DPYSL2 35
  • 92.12 (n)
  • 98.23 (a)
  • 82 (a)
(Mus musculus)
Mammalia Dpysl2 35
  • 90.67 (n)
  • 97.71 (a)
Dpysl2 16
Dpysl2 36
  • 99 (a)
(Monodelphis domestica)
Mammalia DPYSL2 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia DPYSL2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Dpysl2 35
  • 90.2 (n)
  • 97.71 (a)
(Gallus gallus)
Aves DPYSL2 35
  • 83.09 (n)
  • 94.67 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia DPYSL2 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl2 35
  • 78.15 (n)
  • 89.18 (a)
Str.15312 35
(Danio rerio)
Actinopterygii dpysl2b 36
  • 90 (a)
Dr.29680 35
fruit fly
(Drosophila melanogaster)
Insecta CRMP 37
  • 46 (a)
(Caenorhabditis elegans)
Secernentea unc-33 37
  • 34 (a)
dhp-2 37
  • 48 (a)
dhp-1 37
  • 47 (a)
Species with no ortholog for DPYSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL2 Gene

Gene Tree for DPYSL2 (if available)
Gene Tree for DPYSL2 (if available)

Paralogs for DPYSL2 Gene

Paralogs for DPYSL2 Gene

Selected SIMAP similar genes for DPYSL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DPYSL2: view

Variants for DPYSL2 Gene

Sequence variations from dbSNP and Humsavar for DPYSL2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10042 -- 26,658,147(+) GGAAC(A/G)CCTAA utr-variant-3-prime
rs10495 -- 26,657,956(+) AGATG(A/G)TTTTT utr-variant-3-prime
rs11527 -- 26,657,736(+) TACCG(A/G)GTCAT utr-variant-3-prime
rs11863 -- 26,656,800(+) TCACA(C/T)GTGGA utr-variant-3-prime
rs17666 -- 26,657,942(+) TAGGA(A/C/T)TTAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DPYSL2 Gene

Variant ID Type Subtype PubMed ID
dgv7764n71 CNV Loss 21882294
nsv6130 CNV Insertion 18451855
nsv824581 CNV Gain 20364138
esv988025 CNV Insertion 20482838
nsv465626 CNV Loss 19166990

Relevant External Links for DPYSL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL2 Gene

Disorders for DPYSL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DPYSL2 Gene including...

Search for DPYSL2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DPYSL2 Gene

(8) Novoseek inferred disease relationships for DPYSL2 Gene

Disease -log(P) Hits PubMed IDs
neurofibrillary tangles 64 3
senile plaques 57.3 1
alzheimers disease 54.5 10
shock 39.7 8
neurodegeneration 39 2

Relevant External Links for DPYSL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DPYSL2: view

No data available for UniProtKB/Swiss-Prot for DPYSL2 Gene

Publications for DPYSL2 Gene

  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N. … Nonaka M. (Gene 1996) 2 3 4 23
  2. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. (PMID: 10757975) Gu Y. … Ihara Y. (Biochemistry 2000) 3 4 23
  3. Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. (PMID: 10574455) Kitamura K. … Nonaka M. (DNA Res. 1999) 3 4 23
  4. CRMP-2 is involved in kinesin-1-dependent transport of the Sra- 1/WAVE1 complex and axon formation. (PMID: 16260607) Kawano Y. … Kaibuchi K. (Mol. Cell. Biol. 2005) 3 4 23
  5. An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis. (PMID: 16321170) Zhao X. … He L. (Int. J. Neuropsychopharmacol. 2006) 3 23 48

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