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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPYSL2 Gene

protein-coding   GIFtS: 68
GCID: GC08P026371

Dihydropyrimidinase-Like 2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dihydropyrimidinase-Like 21 2     ULIP22 3
CRMP22 3 5     DRP22 5
Unc-33-Like Phosphoprotein 22 3     DHPRP22
CRMP-22 3     Collapsin Response Mediator Protein HCRMP-22
DRP-22 3     Dihydropyrimidinase-Related Protein 22
N2A32 3     Collapsin Response Mediator Protein 23
ULIP-22 3     

External Ids:    HGNC: 30141   Entrez Gene: 18082   Ensembl: ENSG000000929647   OMIM: 6024635   UniProtKB: Q165553   

Export aliases for DPYSL2 gene to outside databases

Previous GC identifers: GC08P026208 GC08P026792 GC08P026457 GC08P026491 GC08P024980


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPYSL2 Gene:
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins
form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes
microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic
signaling through interactions with calcium channels. This gene has been implicated in multiple neurological
disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's
disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Sep 2011)

GeneCards Summary for DPYSL2 Gene: 
DPYSL2 (dihydropyrimidinase-like 2) is a protein-coding gene. Diseases associated with DPYSL2 include tauopathy, and traumatic brain injury, and among its related super-pathways are Development Slit-Robo signaling and Axon guidance. GO annotations related to this gene include protein kinase binding and dihydropyrimidinase activity. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555
Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal
growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling
of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis

Gene Wiki entry for DPYSL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPYSL2 gene promoter:
         TBP   NF-1   HOXA3   HNF-1A   GATA-2   HNF-1   Sox9   aMEF-2   NF-kappaB1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPYSL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPYSL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p22-p21

DPYSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPYSL2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P026371:  view genomic region     (about GC identifiers)

Start:
26,371,709 bp from pter      End:
26,515,694 bp from pter
Size:
143,986 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 2  
Size: 572 amino acids; 62294 Da
Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through
its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4 (By similarity). Interacts with CLN6
Subcellular location: Cytoplasm (By similarity)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
2 PDB 3D structures from and Proteopedia for DPYSL2:
2GSE (3D)        2VM8 (3D)    
Secondary accessions: A8K5H2 B4DR31 D3DSS7 O00424
Alternative splicing: 2 isoforms:  Q16555-1   Q16555-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DPYSL2: NX_Q16555

Explore proteomics data for DPYSL2 at MOPED 

Post-translational modifications:

  • UniProtKB: 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically
    labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509
  • UniProtKB: Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly
    in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent
    phosphorylation by GSK3B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16555

  • DPYSL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPYSL2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001184222.1  NP_001231533.1  NP_001377.1  

    ENSEMBL proteins: 
     ENSP00000427985   ENSP00000427954   ENSP00000309539   ENSP00000431117  
    Reactome Protein details: Q16555
    Human Recombinant Protein Products for DPYSL2: 
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    Cloud-Clone Corp. Proteins for DPYSL2 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005874colocalizes with microtubule IDA--
    GO:0016020colocalizes with membrane IDA--

    DPYSL2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR006680 Amidohydro_1
     IPR011059 Metal-dep_hydrolase_composite

    Graphical View of Domain Structure for InterPro Entry Q16555

    ProtoNet protein and cluster: Q16555

    2 Blocks protein domains:
    IPB005847 Dihydroorotase region
    IPB011550 Amidohydrolase-like


    UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    DPYSL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPYL2_HUMAN, Q16555
    Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal
    growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling
    of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis

         Genatlas biochemistry entry for DPYSL2:
    dihydropyrimidinase related protein 2,mainly expressed in the fetal and neonatal brain,involved in the
    developmental process of the nervous system

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004157dihydropyrimidinase activity TAS8973361
    GO:0005515protein binding IPI16260607
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides ----
         
    DPYSL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DPYSL2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dpysl2):
     nervous system 

    DPYSL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPYSL2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPYSL2 
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    SwitchGear 3'UTR luciferase reporter plasmidDPYSL2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DPYSL2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Cytoskeleton remodeling Slit-Robo signaling0.92
    2Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    Recycling pathway of L10.38
    3Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion0.94
    4Sema4D in semaphorin signaling
    Semaphorin interactions0.41
    5SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    CRMPs in Sema3A signaling0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DPYSL2
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Slit-Robo signaling


    3 Cell Signaling Technology (CST) Pathways for DPYSL2
        Neuroscience
    Cytoskeletal Signaling
    PI3K / Akt Signaling

    2 GeneGo (Thomson Reuters) Pathways for DPYSL2
        Neurophysiological process Receptor-mediated axon growth repulsion
    Development Slit-Robo signaling

    2 BioSystems Pathways for DPYSL2
        BDNF signaling pathway
    Regulation of Microtubule Cytoskeleton

    5/6        Reactome Pathways for DPYSL2 (see all 6)
        CRMPs in Sema3A signaling
    L1CAM interactions
    Recycling pathway of L1
    Developmental Biology
    Semaphorin interactions


    1         Kegg Pathway  (Kegg details for DPYSL2):
        Axon guidance


    DPYSL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPYSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for DPYSL2 (Q165552, 3 ENSP000003095394) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRMP1Q141942, 3, ENSP000003216064MINT-8254545 I2D: score=2 STRING: ENSP00000321606
    DPYSL4O145312, 3, ENSP000003398504MINT-8254556 I2D: score=2 STRING: ENSP00000339850
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006139nucleobase-containing compound metabolic process TAS8973361
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0006897endocytosis IMP--
    GO:0007010cytoskeleton organization ISS--

    DPYSL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DPYSL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPYSL2 (DPYL2)

    1 HMDB Compound for DPYSL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ureidopropionic acid3-Ureido-propionate (see all 20)462-88-4--

    5 Novoseek inferred chemical compound relationships for DPYSL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 55.5 8 17522440 (1), 17521179 (1), 18647502 (1), 17907270 (1) (see all 7)
    glycogen 49 7 15652488 (1), 16190365 (1), 16343426 (1), 15483118 (1) (see all 7)
    glutamate 25.1 2 18647502 (1), 16009011 (1)
    creatinine 7.63 2 17018872 (1), 17683050 (1)
    phosphatidylinositol 1.25 2 17185510 (1), 15207709 (1)

    Search CenterWatch for drugs/clinical trials and news about DPYSL2 / DPYL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPYSL2 gene (3 alternative transcripts): 
    NM_001197293.2  NM_001244604.1  NM_001386.5  

    Unigene Cluster for DPYSL2:

    Dihydropyrimidinase-like 2
    Hs.593187  [show with all ESTs]
    Unigene Representative Sequence: NM_001197293
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521913(uc003xfa.3) ENST00000493789 ENST00000311151(uc011lag.2 uc003xfb.2 uc011lah.2)
    ENST00000523027 ENST00000523690 ENST00000523093 ENST00000521983 ENST00000474808


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    Additional mRNA sequence: 

    AB209195.1 AB370194.1 AB370195.1 AK054747.1 AK092377.1 AK223557.1 AK291287.1 AK299077.1 
    BC056408.1 BC067109.1 BX647115.1 D78013.1 U17279.1 X91250.1 

    24/26 DOTS entries (see all 26):

    DT.100893756  DT.91738423  DT.100893789  DT.100031380  DT.97780290  DT.100744572  DT.100893749  DT.100893775 
    DT.95312424  DT.121481977  DT.100893762  DT.91649615  DT.121481887  DT.95312476  DT.99966080  DT.100656878 
    DT.100893765  DT.121481920  DT.121481968  DT.40115800  DT.92454949  DT.95312421  DT.95312496  DT.100040997 

    24/517 AceView cDNA sequences (see all 517):

    BE748438 Z44143 AI376141 CA429397 F05613 AV726170 AW504792 AI004685 
    AA487460 T35393 Z38543 F07479 F09305 NM_001386 AA908798 BM786249 
    D38661 BF725718 BQ772893 AL603228 BM729299 AI128832 BF115449 T31558 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:        -                 -                                         -     -                                                                     
    SP2:                          -                                                                                                                     
    SP3:                                                                                                                                                
    SP4:                                                                                                              -     -                           
    SP5:                                                                    -                                                                           


    ECgene alternative splicing isoforms for DPYSL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPYSL2 expression in normal human tissues (normalized intensities)      DPYSL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACGCCTAA
    DPYSL2 Expression
    About this image


    DPYSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/37 selected tissues (see all 37) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             brain/midbrain   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon

    See DPYSL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPYSL2

    SOURCE GeneReport for Unigene cluster: Hs.593187

    UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DPYSL2 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpysl21 , 5 dihydropyrimidinase-like 21, 5 90.67(n)1
    97.71(a)1
      14 (34.60 cM)5
    129341  NM_009955.31  NP_034085.21 
     668028645 
    chicken
    (Gallus gallus)
    Aves DPYSL21 dihydropyrimidinase-like 2 83.09(n)
    94.67(a)
      395155  NM_204494.1  NP_989825.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPYSL26
    --
    --
    97(a)
    21(a)
    1 ↔ 1
    possible ortholog
    GL343445.1(507420-555330)
    3(35153312-35184148)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC059982.12   -- 75.33(n)    BC059982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.296802 Transcribed sequence with moderate similarity to protein more 74.48(n)    57043494 
    fruit fly
    (Drosophila melanogaster)
    Insecta CRMP3 dihydropyrimidinase 46(a)   83B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea dhp-23 Ulip like protein 48(a)
    (best of 3)
      IV(9978361-9980884)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAL16
    Allantoinase, converts allantoin to allantoate in ...
    20(a)
    1 → many
    IX(406260-407642)


    ENSEMBL Gene Tree for DPYSL2 (if available)
    TreeFam Gene Tree for DPYSL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPYSL2 gene
    DPYSL32  CRMP12  DPYSL42  DPYSL52  DPYS2  
    5 SIMAP similar genes for DPYSL2 using alignment to 4 protein entries:     DPYL2_HUMAN (see all proteins):
    CRMP1    DPYSL3    DPYSL5    DPYSL4    DPYS

    DPYSL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3442 SNPs in DPYSL2 are shown (see all 3442)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363164
    A colorectal cancer sample4--see VAR_0363162 R C mis40--------
    VAR_0220164
    ----see VAR_0220162 A T mis40--------
    rs98864481,2
    C,F,H--24914544(+) AAATCT/CGTTTC 1 -- us2k120Minor allele frequency- C:0.20NA NS EA WA 2482
    rs569680921,2
    C--24931610(+) CTATC-/T/TATC
            
    ATCTA
    1 -- int10--------
    rs1445352571,2
    C--24931611(+) CTATC-/ATC   
       TATCT
    ATCTA
    1 -- int10--------
    rs775317291,2
    C--24944736(+) GTTTTA/TAAAAA 1 -- int10--------
    rs1115856911,2
    C--24945823(+) CTTGGT/-TTTTT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs760610131,2
    C--24946388(+) CACAA-/TTTC/TTTCACTTCC/
    TTTCACTTCCATAAGGGTT
    ACAAA
    1 -- int10--------
    rs2001446241,2
    C--24948112(+) AAAAA-/TAATCT 1 -- int10--------
    rs1896063801,2
    --24958540(+) ATATAA/TATTAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DPYSL2 (26371709 - 26515694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DPYSL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6130CNV Insertion18451855
    esv988025CNV Insertion20482838
    nsv465626CNV Loss19166990
    dgv7764n71CNV Loss21882294
    nsv824581CNV Gain20364138


    Human Gene Mutation Database (HGMD): DPYSL2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602463    OMIM disorders: --

    20/24 diseases for DPYSL2 (see all 24):    About MalaCards
    tauopathy    traumatic brain injury    bipolar i disorder    neuronal ceroid lipofuscinosis
    brain injury    alzheimer's disease    brain disease    bipolar disorder
    major depressive disorder    thymoma    temporal lobe epilepsy    neurofibromatosis
    schizophrenia    encephalomyelitis    down syndrome    lateral sclerosis
    amyotrophic lateral sclerosis    ischemia    parkinson's disease    neuroblastoma

    2 diseases from the University of Copenhagen DISEASES database for DPYSL2:
    Alzheimer's disease     Schizophrenia

    DPYSL2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for DPYSL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 64 3 19519308 (1), 18699782 (1), 15331161 (1)
    senile plaques 57.3 1 18000012 (1)
    alzheimers disease 54.5 12 19519308 (2), 10666674 (2), 18000012 (1), 18699782 (1) (see all 8)
    shock 39.7 9 17522440 (1), 17521179 (1), 17018872 (1), 12354300 (1) (see all 8)
    neurodegeneration 39 3 19519308 (1), 15672539 (1)
    brain diseases 34.6 3 10666674 (2)
    schizophrenia 25 33 15027329 (5), 12679234 (5), 16321170 (5), 15858820 (4) (see all 6)
    bipolar disorder 19.7 3 12951196 (1), 17105906 (1)

    Genetic Association Database (GAD): DPYSL2
    Human Genome Epidemiology (HuGE) Navigator: DPYSL2 (8 documents)

    Export disorders for DPYSL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPYSL2 gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with DPYSL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 2, 3, 9 Hamajima N.... Nonaka M. (1996)
    2. An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis. (PubMed id 16321170)1, 4, 9 Zhao X....He L. (2006)
    3. CRMP-2 is involved in kinesin-1-dependent transport of the Sra- 1/WAVE1 complex and axon formation. (PubMed id 16260607)1, 2, 9 Kawano Y.... Kaibuchi K. (2005)
    4. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. (PubMed id 10757975)1, 2, 9 Gu Y.... Ihara Y. (2000)
    5. Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. (PubMed id 10574455)1, 2, 9 Kitamura K.... Nonaka M. (1999)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. A two-stage case-control association study of the dih ydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. (PubMed id 20414250)1, 4 Koide T....Ozaki N. (2010)
    8. Protein product of CLN6 gene responsible for variant l ate-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2. (PubMed id 19235893)1, 2 Benedict J.W....Pearce D.A. (2009)
    9. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (2009)
    10. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1808 HGNC: 3014 AceView: DPYSL2 Ensembl:ENSG00000092964 euGenes: HUgn1808
    ECgene: DPYSL2 Kegg: 1808 H-InvDB: DPYSL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPYSL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPYSL2 gene:
    Search GeneIP for patents involving DPYSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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