Aliases for DPYSL2 Gene
External Ids for DPYSL2 Gene
Previous GeneCards Identifiers for DPYSL2 Gene
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for DPYSL2 Gene
DPYSL2 (Dihydropyrimidinase Like 2) is a Protein Coding gene. Diseases associated with DPYSL2 include Alzheimer Disease and Schizophrenia. Among its related pathways are Endocytic Trafficking of EGFR and PI3K / Akt Signaling. GO annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is CRMP1.
UniProtKB/Swiss-Prot for DPYSL2 Gene
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.