DPYSL2 Gene
protein-coding GIFtS: 66
GCID: GC08P026371
|
|
dihydropyrimidinase-like 2
| |
Aliases
for DPYSL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dihydropyrimidinase-Like 21 2 | | N2A32 3 | | CRMP21 2 3 5 | | ULIP-22 3 | | DRP-21 2 3 | | ULIP22 3 | | DRP21 2 5 | | Collapsin Response Mediator Protein HCRMP-22 | | DHPRP21 2 | | Dihydropyrimidinase-Related Protein 22 | | Unc-33-Like Phosphoprotein 22 3 | | Collapsin Response Mediator Protein 23 | | CRMP-22 3 | | |
Export aliases for DPYSL2 gene to outside databasesPrevious GC identifers: GC08P026208 GC08P026792 GC08P026457 GC08P026491 GC08P024980 |
Summaries
for DPYSL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DPYSL2:
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins formhomo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotesmicrotubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synapticsignaling through interactions with calcium channels. This gene has been implicated in multiple neurologicaldisorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer'sdisease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.(provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growthcone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of thecytoskeleton (By similarity). Plays a role in neuron projection morphogenesis
Gene Wiki entry for DPYSL2
|
Genomic Views
for DPYSL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DPYSL2 gene promoter:
TBP NF-1 HOXA3 HNF-1A GATA-2 HNF-1 Sox9 aMEF-2 NF-kappaB1 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for DPYSL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYSL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p22-p21 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p22-p21DPYSL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P026371: view genomic region
(about GC identifiers)
Start:
|
26,371,791 bp from pter |
End:
|
26,515,694 bp from pter |
Size:
|
143,904 bases |
Orientation:
|
plus strand |
|
Proteins
for DPYSL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555 (See
protein sequence)Recommended Name: Dihydropyrimidinase-related protein 2 Size: 572 amino acids; 62294 Da
Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through itsC-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4 (By similarity). Interacts with CLN6
Subcellular location: Cytoplasm (By similarity)
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence fordihydropyrimidinase activity. Its enzyme activity is therefore unsure
2 PDB 3D structures from  and Proteopedia  for DPYSL2:2GSE (3D)
2VM8 (3D)
Secondary accessions: A8K5H2 B4DR31 D3DSS7 O00424Alternative splicing: 2 isoforms: Q16555-1 Q16555-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DPYSL2: NX_Q16555
Post-translational modifications:
3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specificallylabels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-5091
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly inaxons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequentphosphorylation by GSK3B1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16555
DPYSL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001184222.1 NP_001231533.1 NP_001377.1
ENSEMBL proteins: ENSP00000427985 ENSP00000427954 ENSP00000309539 ENSP00000428909 ENSP00000431117 Reactome Protein details: Q16555
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
DPYSL2 for ontologies About GeneDecksing
DPYSL2 Antibody Products:
Assay Products for DPYSL2: |
Protein
Domains /
Families
for DPYSL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPYSL2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q16555ProtoNet protein and cluster: Q16555 2 Blocks protein families: IPB005847 Dihydroorotase region IPB011550 Amidohydrolase-like
UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily |
Function
for DPYSL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growthcone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of thecytoskeleton (By similarity). Plays a role in neuron projection morphogenesis Genatlas biochemistry entry for DPYSL2:dihydropyrimidinase related protein 2,mainly expressed in the fetal and neonatal brain,involved in the developmentalprocess of the nervous system
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPYSL2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPYSL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DPYSL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYSL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004157 | dihydropyrimidinase activity |
TAS | 8973361 | | GO:0005515 | protein binding |
IPI | 19235893 | | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
-- | -- | | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
-- | -- | | GO:0019901 | protein kinase binding |
IEA | -- |
DPYSL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DPYSL2:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Dpysl2):
DPYSL2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DPYSL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Cytoskeleton remodeling Slit-Robo signaling | | | 3 | Neurophysiological process Receptor-mediated axon growth repulsion | | | 4 | Neuroscience | | | 5 | Cytoskeletal Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for DPYSL2
3 
Cell Signaling Technology (CST) Pathways for DPYSL2
2  GeneGo (Thomson Reuters) Pathways for DPYSL2
5/6 
Reactome Pathways for DPYSL2 (see all 6)
1 
Kegg Pathway (Kegg details for DPYSL2):
DPYSL2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPYSL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for DPYSL2 (Q165552, 3 ENSP000003095394) via UniProtKB, MINT, STRING, and/or I2D (see all 48)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
DPYSL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DPYSL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DPYSL2 for compounds About GeneDecksing
 Browse Tocris compounds for DPYSL2
1 HMDB Compound for DPYSL2 About this table
5 Novoseek chemical compound relationships for DPYSL2 gene About this table
Search CenterWatch for drugs/clinical trials and news about DPYSL2 / DPYL2
|
Transcripts
for DPYSL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DPYSL2 gene (3 alternative transcripts): NM_001197293.2 NM_001244604.1 NM_001386.5 Unigene Cluster for DPYSL2: Dihydropyrimidinase-like 2 Hs.593187 [show with all ESTs]Unigene Representative Sequence: NM_0011972939 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000521913(uc003xfa.3) ENST00000493789 ENST00000311151(uc011lag.2 uc003xfb.2 uc011lah.2)
ENST00000522745 ENST00000523027 ENST00000523690 ENST00000523093 ENST00000521983
ENST00000474808
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPYSL2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPYSL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DPYSL2 (NM_001386) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPYSL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYSL2 |
Additional cDNA sequence: AB209195.1 AB370194.1 AB370195.1 AK054747.1 AK092377.1 AK223557.1 AK291287.1 AK299077.1 BC056408.1 BC067109.1 BX647115.1 D78013.1 U17279.1 X91250.1 24/26 DOTS entries (see all 26): DT.100893756 DT.91738423 DT.100893789 DT.100031380 DT.97780290 DT.100744572 DT.100893749 DT.100893775 DT.95312424 DT.121481977 DT.100893762 DT.91649615 DT.121481887 DT.95312476 DT.99966080 DT.100656878 DT.100893765 DT.121481920 DT.121481968 DT.40115800 DT.92454949 DT.95312421 DT.95312496 DT.100040997 24/517 AceView cDNA sequences (see all 517): BE748438 Z44143 AI376141 CA429397 F05613 AV726170 AW504792 AI004685 AA487460 T35393 Z38543 F07479 F09305 NM_001386 AA908798 BM786249 D38661 BQ772893 BF725718 AL603228 BM729299 AI128832 BF115449 T31558
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL2 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DPYSL2
|
Expression
for DPYSL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPYSL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACGCCTAA
About this image
See DPYSL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPYSL2
SOURCE GeneReport for Unigene cluster: Hs.593187
UniProtKB/Swiss-Prot: DPYL2_HUMAN, Q16555Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for DPYSL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPYSL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPYSL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPYSL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPYSL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL2 |
Orthologs
for DPYSL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for DPYSL2 gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DPYSL21 |
dihydropyrimidinase-like 2 |
83.09(n)
94.67(a) |
|
395155 NM_204494.1 NP_989825.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DPYSL26 |
-- |
81(a) |
1 ↔ 1 |
GL343445.1(508757-572279) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC059982.12 |
-- |
75.33(n) |
|
BC059982.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.296802 |
Transcribed sequence with moderate similarity to protein more |
74.48(n) |
|
57043494 |
worm
(Caenorhabditis elegans) |
Secernentea |
dhp-23 |
Ulip like protein |
48(a)
(best of 3) |
|
IV(9978361-9980884) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PYD26 |
pyrimidine 2 |
40(a) |
1 → many |
5(3941528-3944811) |
rice
(Oryza sativa) |
Liliopsida |
-- |
dihydropyrimidinase, putative, expressed |
41(a) |
1 → many |
1(34294608-34306006) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
hyuA6 |
D-stereospecific phenylhydantoinase |
34(a) |
1 → many |
Chromosome(3008050-3009435) |
ENSEMBL Gene Tree for DPYSL2 (if available)
TreeFam Gene Tree for DPYSL2 (if available) |
Paralogs
for DPYSL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DPYSL2 gene
- CRMP12 DPYSL32 DPYSL52 DPYSL42 DPYS2
5 SIMAP similar genes for DPYSL2 using alignment to 4 protein entries: DPYL2_HUMAN (see all proteins):CRMP1 DPYSL3 DPYSL5 DPYSL4 DPYS
DPYSL2 for paralogs About GeneDecksing
|
Genomic Variants
for DPYSL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DPYSL2 (26371791 - 26515694 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DPYSL2: --
Human Gene Mutation Database (HGMD): DPYSL2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPYSL2 |
|
Disorders
/ Diseases
for DPYSL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPYSL2 for disorders About GeneDecksing
OMIM gene information: 602463
OMIM disorders: --
20/30  diseases for DPYSL2 (see all 30): About MalaCardsalzheimer's disease temporal lobe epilepsy traumatic brain injury major depressive disorder
brain injury amyotrophic lateral sclerosis dihydropyrimidinuria bipolar i disorder
lateral sclerosis bipolar disorder neuronitis brain disease
tauopathy neurodegeneration down syndrome neurodegenerative disease
thymoma neurofibromatosis encephalomyelitis parkinson's disease
2 diseases from the University of Copenhagen DISEASES database for DPYSL2:Alzheimer's disease Schizophrenia 8 Novoseek disease relationships for DPYSL2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neurofibrillary tangles |
64 |
3 |
19519308 (1), 18699782 (1), 15331161 (1) |
| senile plaques |
57.3 |
1 |
18000012 (1) |
| alzheimers disease |
54.5 |
12 |
19519308 (2), 10666674 (2), 18000012 (1), 18699782 (1) (see all 8) |
| shock |
39.7 |
9 |
17522440 (1), 17521179 (1), 17018872 (1), 12354300 (1) (see all 8) |
| neurodegeneration |
39 |
3 |
19519308 (1), 15672539 (1) |
| brain diseases |
34.6 |
3 |
10666674 (2) |
| schizophrenia |
25 |
33 |
15027329 (5), 12679234 (5), 16321170 (5), 15858820 (4) (see all 6) |
| bipolar disorder |
19.7 |
3 |
12951196 (1), 17105906 (1) |
Genetic Association Database (GAD): DPYSL2
Human Genome Epidemiology (HuGE) Navigator: DPYSL2 (8 documents)
Export disorders for DPYSL2 gene to outside databases
|
Publications
for DPYSL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPYSL2 gene, integrated from 9 sources (see all 137):
(articles sorted by number of sources associating them with DPYSL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 2, 3, 9 Hamajima N.... Nonaka M. (1996)
- An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis. (PubMed id 16321170)1, 4, 9 Zhao X....He L. (2006)
- CRMP-2 is involved in kinesin-1-dependent transport of the Sra- 1/WAVE1 complex and axon formation. (PubMed id 16260607)1, 2, 9 Kawano Y.... Kaibuchi K. (2005)
- Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. (PubMed id 10757975)1, 2, 9 Gu Y.... Ihara Y. (2000)
- Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. (PubMed id 10574455)1, 2, 9 Kitamura K.... Nonaka M. (1999)
- Protein product of CLN6 gene responsible for variant l ate-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2. (PubMed id 19235893)1, 2 Benedict J.W....Pearce D.A. (2009)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PubMed id 16380905)1, 4 Fallin M.D....Pulver A.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
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External Searches for DPYSL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DPYSL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DPYSL2 gene
(According to HUGE)
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Specialized Databases showing DPYSL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for DPYSL2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for DPYSL2 gene:
Search GeneIP for patents involving DPYSL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DPYSL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for DPYSL2 | | OriGene shRNA RFP for DPYSL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPYSL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPYSL2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DPYSL2 | | OriGene 3'-UTR Clone for DPYSL2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPYSL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPYSL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DPYSL2 | | OriGene Custom Protein Services for DPYSL2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPYSL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPYSL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYSL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPYSL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPYSL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPYSL2 |
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| | Antibodies & Assays for DPYSL2 (CRMP-2) |
| | | | Search Tocris compounds for DPYSL2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYSL2 |
|  |  |  | | | | ThermoFisher Antibodies for DPYSL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYSL2 |
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