Aliases for DPYSL2 Gene
External Ids for DPYSL2 Gene
Previous GeneCards Identifiers for DPYSL2 Gene
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for DPYSL2 Gene
DPYSL2 (Dihydropyrimidinase Like 2) is a Protein Coding gene. Diseases associated with DPYSL2 include Alzheimer Disease and Schizophrenia. Among its related pathways are Axon guidance and Regulation of Microtubule Cytoskeleton. GO annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is CRMP1.
UniProtKB/Swiss-Prot for DPYSL2 Gene
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.