DPYS Gene
protein-coding GIFtS: 63
GCID: GC08M105391
|
|
dihydropyrimidinase
| |
Aliases
for DPYS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dihydropyrimidinase1 | | EC 3.5.2.23 8 | | DHPase1 2 3 | | Hydantoinase3 | | DHP2 3 5 | | Hydantoinase3 | | Dihydropyrimidine Amidohydrolase2 3 | | |
Export aliases for DPYS gene to outside databasesPrevious GC identifers: GC08M104397 GC08M105459 GC08M105060 GC08M105348 GC08M105460 GC08M100592 |
Summaries
for DPYS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DPYS:
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism.Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kbtranscript. Defects in the DPYS gene are linked to dihydropyrimidinuria. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DPYS_HUMAN, Q14117Function: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening ofdihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymineto N-carbamyl-amino isobutyrate
Gene Wiki entry for DPYS
|
Genomic Views
for DPYS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DPYS gene promoter:
GATA-3 CUTL1 E4BP4 GATA-1 GATA-2 Egr-4 FOXO1a Chx10 Msx-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DPYS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22DPYS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M105391: view genomic region
(about GC identifiers)
Start:
|
105,391,652 bp from pter |
End:
|
105,479,281 bp from pter |
Size:
|
87,630 bases |
Orientation:
|
minus strand |
|
Proteins
for DPYS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPYS_HUMAN, Q14117 (See
protein sequence)Recommended Name: Dihydropyrimidinase Size: 519 amino acids; 56630 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Homotetramer (Probable)
1 PDB 3D structure from  and Proteopedia  for DPYS:2VR2 (3D)
Explore the universe of human proteins at neXtProt for DPYS: NX_Q14117
Post-translational modifications:
Carbamylation allows a single lysine to coordinate two zinc ions (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14117
4/7 DME Specific Peptides for DPYS (Q14117) (see all 7)
DPYS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001376.1
ENSEMBL proteins: ENSP00000276651 ENSP00000436654 ENSP00000430246 Reactome Protein details: Q14117
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
DPYS for ontologies About GeneDecksing
DPYS Antibody Products:
Assay Products for DPYS: |
Protein
Domains /
Families
for DPYS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPYS for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14117ProtoNet protein and cluster: Q14117 1 Blocks protein family: IPB005847 Dihydroorotase region
UniProtKB/Swiss-Prot: DPYS_HUMAN, Q14117Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily |
Function
for DPYS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DPYS_HUMAN, Q14117Function: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening ofdihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymineto N-carbamyl-amino isobutyrateCatalytic activity: 5,6-dihydrouracil + H(2)O = 3-ureidopropanoate Genatlas biochemistry entry for DPYS:dihydropyrimidinase
Enzyme Number (IUBMB): EC 3.5.2.21 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPYS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPYS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DPYS (NM_001385) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPYS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYS |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
DPYS for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DPYS:
|
Pathways & Interactions
for DPYS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Beta-alanine metabolism | | | 2 | Pyrimidine metabolism | | | 3 | Metabolism | | | 4 | Fluoropyrimidine Activity | | | 5 | beta-Alanine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DPYS
1  GeneGo (Thomson Reuters) Pathway for DPYS
3  BioSystems Pathways for DPYS
4 
Reactome Pathways for DPYS
1  PharmGKB Pathway for DPYS
5 
Kegg Pathways (Kegg details for DPYS):
DPYS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPYS
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for DPYS (Q141173 ENSP000002766514) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
DPYS for ontologies About GeneDecksing
|
Drugs & Compounds
for DPYS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DPYS for compounds About GeneDecksing
 Browse Tocris compounds for DPYS
5 HMDB Compounds for DPYS About this table
10/16 Novoseek chemical compound relationships for DPYS gene (see all 16) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 5-phenylhydantoin |
94.3 |
2 |
11910755 (1), 12557399 (1) |
| 5-benzylhydantoin |
91.9 |
3 |
12557399 (2), 11910755 (1) |
| dihydrouracil |
91.7 |
3 |
17383919 (1), 12271438 (1) |
| hydantoin |
91.6 |
7 |
10222578 (1), 11910755 (1), 11849938 (1), 15733920 (1) (see all 7) |
| 5,6-dihydrothymine |
88.1 |
3 |
17383919 (1), 12271438 (1) |
| pyrimidine |
77.8 |
15 |
19571472 (1), 17383919 (1), 16498612 (1), 11482736 (1) (see all 12) |
| dexrazoxane |
74.5 |
5 |
15764716 (1), 12433815 (1), 8024952 (1), 7902252 (1) |
| thymine |
60.5 |
1 |
12271438 (1) |
| 5fluorouracil |
51.5 |
17 |
14555507 (4), 18075467 (1), 15571261 (1), 9816152 (1) (see all 5) |
| purine nucleoside |
43.9 |
1 |
16613999 (1) |
Search CenterWatch for drugs/clinical trials and news about DPYS
|
Transcripts
for DPYS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DPYS gene: NM_001385.2 Unigene Cluster for DPYS: Dihydropyrimidinase Hs.443161 [show with all ESTs]Unigene Representative Sequence: NM_0013857 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000351513(uc003yly.4) ENST00000520806 ENST00000533874 ENST00000520483(uc010mcf.1)
ENST00000521372 ENST00000519217 ENST00000521573
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPYS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPYS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DPYS (NM_001385) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPYS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYS |
Additional cDNA sequence: AK311261.1 BC034395.1 D78011.1 6 DOTS entries: DT.314560 DT.75107450 DT.99977365 DT.91748887 DT.95267968 DT.91748882 24/52 AceView cDNA sequences (see all 52): BG400594 AW612623 AW779331 NM_001385 AI672449 CB157200 AI478498 D78011 BC034395 AI469047 AW300369 BG401640 CB164695 T60449 CA392979 AI291149 AW242821 AV721410 AA987794 AI936331 AV682541 AI765642 AV681903 AI629008
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DPYS (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DPYS
|
Expression
for DPYS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPYS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAGCAGG
About this image
See DPYS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPYS
SOURCE GeneReport for Unigene cluster: Hs.443161
UniProtKB/Swiss-Prot: DPYS_HUMAN, Q14117Tissue specificity: Liver and kidney
SABiosciences Custom PCR Arrays for DPYS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPYS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPYS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPYS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPYS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYS |
Orthologs
for DPYS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for DPYS gene from 9/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DPYS1 |
dihydropyrimidinase |
72.19(n)
76.36(a) |
|
420266 XM_418377.3 XP_418377.3 |
lizard
(Anolis carolinensis) |
Reptilia |
DPYS6 |
-- |
82(a) |
1 ↔ 1 |
4(13092817-13130378) |
zebrafish
(Danio rerio) |
Actinopterygii |
dpys1 |
dihydropyrimidinase |
69.69(n)
75.4(a) |
|
100144569 NM_001123063.1 NP_001116535.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CRMP1 , 3 |
dihydropyrimidinase3
Collapsin Response Mediator Protein1 |
55(a)3
59.68(n)1
59.32(a)1 |
|
83B23
406751 NM_169072.21 NP_730954.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
dhp-21 , 3 |
Ulip like protein3
Protein DHP-21 |
58(a)
(best of 3)3
57.78(n)1
58.68(a)1 |
|
IV(9978361-9980884)3
1778521 NM_069396.51 NP_501797.11 |
K. lactis yeast
(Kluyveromyces lactis) |
Saccharomycetes |
KLLA0C19107g1 |
hypothetical protein |
44.67(n)
33.33(a) |
|
2892062 XM_453052.1 XP_453052.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PYD21 |
pyrimidine 2 |
53.7(n)
48.72(a) |
|
831093 NM_121258.3 NP_568258.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.336102 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.18(n) |
|
AK072454.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
hyuA6 |
D-stereospecific phenylhydantoinase |
35(a) |
1 → many |
Chromosome(3008050-3009435) |
ENSEMBL Gene Tree for DPYS (if available)
TreeFam Gene Tree for DPYS (if available) |
Paralogs
for DPYS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DPYS gene
- CRMP12 DPYSL32 DPYSL52 DPYSL42 DPYSL22
5 SIMAP similar genes for DPYS using alignment to 3 protein entries: DPYS_HUMAN (see all proteins):CRMP1 DPYSL2 DPYSL3 DPYSL4 DPYSL5
DPYS for paralogs About GeneDecksing
|
Genomic Variants
for DPYS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DPYS (105391652 - 105479281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DPYS: --
Human Gene Mutation Database (HGMD): DPYS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPYS |
|
Disorders
/ Diseases
for DPYS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPYS for disorders About GeneDecksing
OMIM gene information: 613326
OMIM disorders: 222748
UniProtKB/Swiss-Prot: DPYS_HUMAN, Q14117
Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD) [MIM:222748]. DHPD is an autosomalrecessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epilepticor convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy
17  diseases for DPYS: About MalaCardsdihydropyrimidinuria 5-fluorouracil toxicity beta-ureidopropionase deficiency papillon-lefevre disease
dihydropyrimidine dehydrogenase deficiency dihydropyrimidinase deficiency beriberi oral squamous cell carcinoma
squamous cell carcinoma convulsions gastric cancer pneumonia
carcinoma tuberculosis hepatitis neuronitis
mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for DPYS:Papillon-Lefevre disease 5 Novoseek disease relationships for DPYS gene About this table
Human Genome Epidemiology (HuGE) Navigator: DPYS (4 documents)
Export disorders for DPYS gene to outside databases
|
Publications
for DPYS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPYS gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with DPYS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 2, 3, 9 Hamajima N.... Nonaka M. (1996)
- Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene. (PubMed id 9718352)1, 2, 9 Hamajima N.... Wada Y. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. (PubMed id 18075467)1, 9 Thomas H.R....Diasio R.B. (2007)
- Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency. (PubMed id 17383919)1, 9 van Kuilenburg A.B....Bosch A.M. (2007)
- Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patie nts. (PubMed id 19649633)1, 9 Fidlerova J....Kleibl Z. (2010)
- Radiochemical assay for determination of dihydropyrimidinase activity using reversed-phase high-performance liquid chromatography. (PubMed id 10410956)1, 9 Van Kuilenburg A.B....Van Gennip A.H. (1999)
- Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism. (PubMed id 18216719)1, 9 Thomas H.R....Diasio R.B. (2008)
- Dihydropyrimidinase deficiency: Phenotype, genotype a nd structural consequences in 17 patients. (PubMed id 20362666)1 van Kuilenburg A.B....Hennekam R.C. (2010)
- Analysis of copy number variation in 8,842 Korean ind ividuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)1 Kim H.Y....Kim H. (2010)
|
External Searches for DPYS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DPYS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DPYS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DPYS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DPYS | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DPYS |
|
| | |
About This Section
| Patent Information for DPYS gene:
Search GeneIP for patents involving DPYS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DPYS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DPYS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPYS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPYS | | | OriGene Protein Over-expression Lysate for DPYS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DPYS | | OriGene 3'-UTR Clone for DPYS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPYS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPYS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DPYS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DPYS | | OriGene Custom Protein Services for DPYS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPYS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPYS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPYS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPYS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPYS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPYS |
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| | | | Search Tocris compounds for DPYS |
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 | | | DPYS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPYS |
|  |  |  | | | | Search ThermoFisher Antibodies for DPYS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPYS |
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