Aliases for DPYS Gene
External Ids for DPYS Gene
Previous GeneCards Identifiers for DPYS Gene
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
GeneCards Summary for DPYS Gene
DPYS (Dihydropyrimidinase) is a Protein Coding gene. Diseases associated with DPYS include Dihydropyrimidinuria and Dihydropyrimidine Dehydrogenase Deficiency. Among its related pathways are Pyrimidine metabolism (REACTOME) and beta-Alanine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and amino acid binding. An important paralog of this gene is DPYSL2.
UniProtKB/Swiss-Prot for DPYS Gene
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.