Aliases for DPYD Gene
External Ids for DPYD Gene
Previous GeneCards Identifiers for DPYD Gene
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for DPYD Gene
DPYD (Dihydropyrimidine Dehydrogenase) is a Protein Coding gene. Diseases associated with DPYD include Dihydropyrimidine Dehydrogenase Deficiency and Dihydropyrimidinuria. Among its related pathways are Pyrimidine metabolism (REACTOME) and beta-Alanine metabolism (KEGG). GO annotations related to this gene include protein homodimerization activity and flavin adenine dinucleotide binding.
UniProtKB/Swiss-Prot for DPYD Gene
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.