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DPY30 Gene

protein-coding   GIFtS: 48
GCID: GC02M032093

Dpy-30 Homolog (C. Elegans)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dpy-30 Homolog (C. Elegans)1 2     Saf192
Dpy-30-Like Protein2 3     dpy-30L2
Cps252     Protein Dpy-30 Homolog2
HDPY-302     Dpy-30L3

External Ids:    HGNC: 245901   Entrez Gene: 846612   Ensembl: ENSG000001629617   OMIM: 6120325   UniProtKB: Q9C0053   

Export aliases for DPY30 gene to outside databases

Previous GC identifers: GC02M032103 GC02M031993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPY30 Gene:
DPY30 is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 (PubMed
17500065)).(supplied by OMIM, May 2008)

GeneCards Summary for DPY30 Gene:
DPY30 (dpy-30 homolog (C. elegans)) is a protein-coding gene. Diseases associated with DPY30 include teratocarcinoma, and paraplegia. GO annotations related to this gene include protein homodimerization activity and identical protein binding.

UniProtKB/Swiss-Prot: DPY30_HUMAN, Q9C005
Function: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly
trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional
activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in
retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4'
methylation at key developmental loci. May also play an indirect or direct role in endosomal transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPY30 gene promoter:
         NCX/Ncx   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Cdc5   POU3F2   GATA-1   E2F-1   E2F   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPY30 promoter sequence
   Search Chromatin IP Primers for DPY30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPY30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p22.3

DPY30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPY30 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M032093:  view genomic region     (about GC identifiers)

Start:
32,092,878 bp from pter      End:
32,264,881 bp from pter
Size:
172,004 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DPY30_HUMAN, Q9C005 (See protein sequence)
Recommended Name: Protein dpy-30 homolog  
Size: 99 amino acids; 11250 Da
Subunit: Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3
(also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or
more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative
components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity).
Interacts with ASH2L; the interaction is direct. Interacts with ARFGEF1. Component of the SET1 complex, at least
composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30
1 PDB 3D structure from and Proteopedia for DPY30:
3G36 (3D)    
Secondary accessions: D6W578

Explore the universe of human proteins at neXtProt for DPY30: NX_Q9C005

Explore proteomics data for DPY30 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys45
  • Modification sites at PhosphoSitePlus

  • See DPY30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115963.1  
    ENSEMBL proteins: 
     ENSP00000345837   ENSP00000295066  

    DPY30 Human Recombinant Protein Products:

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    DPY30 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007858 Dpy-30_motif

    Graphical View of Domain Structure for InterPro Entry Q9C005

    ProtoNet protein and cluster: Q9C005

    1 Blocks protein domain: IPB007858 Dpy-30

    UniProtKB/Swiss-Prot: DPY30_HUMAN, Q9C005
    Similarity: Belongs to the dpy-30 family


    DPY30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPY30_HUMAN, Q9C005
    Function: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly
    trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional
    activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in
    retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4'
    methylation at key developmental loci. May also play an indirect or direct role in endosomal transport

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0042802identical protein binding IPI16189514
    GO:0042803protein homodimerization activity IPI19556245
         
    DPY30 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dpy30):
     mortality/aging 

    DPY30 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPY30
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPY30
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPY30

    miRNA
    Products:
        
    miRTarBase miRNAs that target DPY30:
    hsa-mir-1 (MIRT023776)

    Block miRNA regulation of human, mouse, rat DPY30 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DPY30:
    hsa-miR-139-5p
    SwitchGear 3'UTR luciferase reporter plasmidDPY30 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPY30

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPY30

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPY30_HUMAN, Q9C005: Nucleus. Golgi apparatus, trans-Golgi network. Note=Associated with chromatin at regions
    enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in
    downstream regions of genes or 3' UTRs (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    golgi apparatus3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005802trans-Golgi network IDA19651892
    GO:0035097histone methyltransferase complex IDA17500065

    DPY30 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPY30
    Interactions:

        Search GeneGlobe Interaction Network for DPY30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DPY30 (Q9C0051, 2, 3 ENSP000002950664) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF3O433952, 3, ENSP000003153794MINT-67744 I2D: score=5 STRING: ENSP00000315379
    DYDC1Q8WWB32, 3, ENSP000003612764MINT-67906 I2D: score=4 STRING: ENSP00000361276
    DPY30Q9C0051, 2EBI-744973,EBI-744973 MINT-68261
    ASH2LQ9UBL31, 2, 3, ENSP000003408964EBI-744973,EBI-540797 MINT-66596 I2D: score=6 STRING: ENSP00000340896
    UIMC1Q96RL13, ENSP000003664344I2D: score=2 STRING: ENSP00000366434
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016197endosomal transport IMP19651892
    GO:0051568histone H3-K4 methylation IDA19556245

    DPY30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPY30



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DPY30 gene: 
    NM_032574.2  

    Unigene Cluster for DPY30:

    Dpy-30 homolog (C. elegans)
    Hs.531788  [show with all ESTs]
    Unigene Representative Sequence: BM470539
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446765(uc002rnz.3 uc010ymv.1) ENST00000452582 ENST00000414013
    ENST00000430665 ENST00000422413 ENST00000342166(uc002roa.1 uc002rob.1)
    ENST00000295066
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DPY30 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DPY30:
    hsa-miR-139-5p
    SwitchGear 3'UTR luciferase reporter plasmidDPY30 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DPY30
    Predesigned siRNA for gene silencing in human, mouse, rat DPY30
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    GenScript: all cDNA clones in your preferred vector: DPY30 (NM_032574)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPY30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPY30
    Primer
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    OriGene qPCR primer pairs and template standards for DPY30
    OriGene qSTAR qPCR primer pairs in human, mouse for DPY30
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPY30
      QuantiTect SYBR Green Assays in human, mouse, rat DPY30
      QuantiFast Probe-based Assays in human, mouse, rat DPY30

    Additional mRNA sequence: 

    AF226998.1 BC015970.1 

    15 DOTS entries:

    DT.95300943  DT.446351  DT.100038033  DT.120965250  DT.120965251  DT.99955428  DT.100843334  DT.75130879 
    DT.91677905  DT.95210379  DT.95273290  DT.95273295  DT.99943471  DT.102843127  DT.95363675 

    Selected AceView cDNA sequences (see all 318):

    BE615098 CD250945 CD366686 AA569753 AA911924 AA428154 AA635821 BM701801 
    BM542201 AA026265 BM475171 CB134761 BM909697 AF363446 BG114369 CA943304 
    AK022169 CB852882 BQ021273 T47499 BG576844 BM450206 CR614281 AA610033 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DPY30 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d
    SP1:                          -                 -                 -                           
    SP2:                                            -                 -                           
    SP3:                          -                 -     -           -                           
    SP4:                          -                 -                                             
    SP5:                          -                 -     -     -     -                           


    ECgene alternative splicing isoforms for DPY30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPY30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCATTCCCT
    DPY30 Expression
    About this image

    DPY30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPY30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531788
        Custom PCR Arrays for DPY30
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPY30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPY30 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpy301 , 5 dpy-30 homolog (C. elegans)1, 5 92.59(n)1
    97.98(a)1
      17 (45.64 cM)5
    663101  NM_001146223.11  NP_001139695.11 
     742994745 
    chicken
    (Gallus gallus)
    Aves DPY301 dpy-30 homolog (C. elegans) 84.18(n)
    89.9(a)
      421482  NM_001198907.1  NP_001185836.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPY306
    dpy-30 homolog (C. elegans)
    83(a)
    1 ↔ 1
    1(235477978-235481524)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81752 Xenopus laevis transcribed sequence with moderate similarity more 80.52(n)    48051739 
    zebrafish
    (Danio rerio)
    Actinopterygii dpy301 dpy-30 homolog (C. elegans) 71.01(n)
    80.43(a)
      436711  NM_001002438.2  NP_001002438.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dpy-30L26
    Dpy-30L16
    Dpy-30-like 1
    31(a)
    26(a)
    many → 1
    many → 1
    3L(4046988-4047735)
    2L(10732749-10733307)
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-306
    Protein DPY-30 (dpy-30) mRNA, complete cds
    28(a)
    1 ↔ 1
    V(12191315-12192211) WBGene00001088


    ENSEMBL Gene Tree for DPY30 (if available)
    TreeFam Gene Tree for DPY30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPY30 gene
    2 SIMAP similar genes for DPY30 using alignment to 1 protein entry:     DPY30_HUMAN:
    LOC84661    AK7

    DPY30 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DPY30
    PGOHUM00000239396


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPY30 (see all 344)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38320761,2
    C--32248479(-) TTTTGAATG/-  
            
    GGAAT
    1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs352952821,2
    C--32248480(+) TTCCC-/ATT   
      C
    /CATT
    AAAAA
    1 -- ds50010--------
    rs576406771,2
    C--32248481(+) TCCCA-/TTCA  
            
    AAAAC
    1 -- ds50010--------
    rs1470695331,2
    --32248508(+) CTTGAC/GCATGT 1 -- ds50010--------
    rs1831131371,2
    --32248622(+) ATGCCG/TGAAAC 1 -- ds50010--------
    rs1384643781,2
    --32248852(+) GACTGC/TTGTAT 1 -- ds50010--------
    rs1877895901,2
    --32249066(+) AAATAA/GGTATG 1 -- ut310--------
    rs1910946001,2
    --32249144(+) TGTCCA/GGAAGG 1 -- ut310--------
    rs1837960381,2
    --32249161(+) TACATC/GCAAAA 1 -- ut310--------
    rs1496249221,2
    C--32249176(+) GGAATA/GATCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DPY30 (32092878 - 32264881 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DPY30: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPY30
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612032    OMIM disorders: --

    6 diseases for DPY30:    About MalaCards
    teratocarcinoma    paraplegia    spasticity    hypoxia
    melanoma    leukemia


    DPY30 for disorders           About GeneDecksing


    Export disorders for DPY30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPY30 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DPY30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex. (PubMed id 19481096)1, 2, 9 Wang X.... Rao Z. (J. Mol. Biol. 2009)
    2. A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking. (PubMed id 19651892)1, 2 Xu Z.... Ma D. (J. Cell Biol. 2009)
    3. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. (PubMed id 19556245)1, 2 Patel A.... Cosgrove M.S. (J. Biol. Chem. 2009)
    4. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (Mol. Cell. Biol. 2008)
    5. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. (PubMed id 17500065)1, 2 Cho Y.-W.... Ge K. (J. Biol. Chem. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex. (PubMed id 16260194)1, 9 Dong X....Rao Z. (Biochim. Biophys. Acta 2005)
    9. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    10. DPY30 regulates pathways in cellular senescence through ID protein expression. (PubMed id 23872946)1 Simboeck E....Di Croce L. (EMBO J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84661 HGNC: 24590 AceView: C2orf4 Ensembl:ENSG00000162961 euGenes: HUgn84661
    ECgene: DPY30 H-InvDB: DPY30

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPY30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPY30 gene:
    Search GeneIP for patents involving DPY30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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