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Aliases for DPY30 Gene

Aliases for DPY30 Gene

  • Dpy-30, Histone Methyltransferase Complex Regulatory Subunit 2 3 5
  • Dpy-30-Like Protein 3 4
  • Dpy-30L 3 4
  • Dpy-30 Histone Methyltransferase Complex Regulatory Subunit 3
  • Dpy-30 Homolog (C. Elegans) 2
  • Dpy-30 Homolog 3
  • HDPY-30 3
  • Cps25 3
  • Saf19 3

External Ids for DPY30 Gene

Previous GeneCards Identifiers for DPY30 Gene

  • GC02M032103
  • GC02M031993
  • GC02M032093

Summaries for DPY30 Gene

Entrez Gene Summary for DPY30 Gene

  • This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for DPY30 Gene

DPY30 (Dpy-30, Histone Methyltransferase Complex Regulatory Subunit) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include protein homodimerization activity and identical protein binding.

UniProtKB/Swiss-Prot for DPY30 Gene

  • As part of the MLL1/MLL complex, involved in the methylation of histone H3 at Lys-4, particularly trimethylation. Histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 Lys-4 methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPY30 Gene

Genomics for DPY30 Gene

Regulatory Elements for DPY30 Gene

Enhancers for DPY30 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPY30 on UCSC Golden Path with GeneCards custom track

Promoters for DPY30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPY30 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPY30 Gene

Chromosome:
2
Start:
31,867,809 bp from pter
End:
32,039,840 bp from pter
Size:
172,032 bases
Orientation:
Minus strand

Genomic View for DPY30 Gene

Genes around DPY30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPY30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPY30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY30 Gene

Proteins for DPY30 Gene

  • Protein details for DPY30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C005-DPY30_HUMAN
    Recommended name:
    Protein dpy-30 homolog
    Protein Accession:
    Q9C005
    Secondary Accessions:
    • D6W578

    Protein attributes for DPY30 Gene

    Size:
    99 amino acids
    Molecular mass:
    11250 Da
    Quaternary structure:
    • Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct. Interacts with ARFGEF1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

    Three dimensional structures from OCA and Proteopedia for DPY30 Gene

neXtProt entry for DPY30 Gene

Proteomics data for DPY30 Gene at MOPED

Post-translational modifications for DPY30 Gene

  • Ubiquitination at Lys 35 and Lys 45
  • Modification sites at PhosphoSitePlus

Other Protein References for DPY30 Gene

No data available for DME Specific Peptides for DPY30 Gene

Domains & Families for DPY30 Gene

Protein Domains for DPY30 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DPY30 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C005

UniProtKB/Swiss-Prot:

DPY30_HUMAN :
  • Belongs to the dpy-30 family.
Family:
  • Belongs to the dpy-30 family.
genes like me logo Genes that share domains with DPY30: view

No data available for Gene Families for DPY30 Gene

Function for DPY30 Gene

Molecular function for DPY30 Gene

UniProtKB/Swiss-Prot Function:
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at Lys-4, particularly trimethylation. Histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 Lys-4 methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.

Gene Ontology (GO) - Molecular Function for DPY30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IBA --
genes like me logo Genes that share ontologies with DPY30: view
genes like me logo Genes that share phenotypes with DPY30: view

Animal Models for DPY30 Gene

MGI Knock Outs for DPY30:

Animal Model Products

CRISPR Products

miRNA for DPY30 Gene

miRTarBase miRNAs that target DPY30

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPY30 Gene

Localization for DPY30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY30 Gene

Nucleus. Golgi apparatus, trans-Golgi network. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at Lys-4. Highly enriched in gene promoter regions and 5 UTRs, but not in downstream regions of genes or 3 UTRs (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPY30 Gene COMPARTMENTS Subcellular localization image for DPY30 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DPY30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17500065
GO:0005802 trans-Golgi network IDA 19651892
genes like me logo Genes that share ontologies with DPY30: view

Pathways & Interactions for DPY30 Gene

genes like me logo Genes that share pathways with DPY30: view

Pathways by source for DPY30 Gene

Gene Ontology (GO) - Biological Process for DPY30 Gene

None

No data available for SIGNOR curated interactions for DPY30 Gene

Drugs & Compounds for DPY30 Gene

No Compound Related Data Available

Transcripts for DPY30 Gene

Unigene Clusters for DPY30 Gene

Dpy-30 homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPY30 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: -

Relevant External Links for DPY30 Gene

GeneLoc Exon Structure for
DPY30
ECgene alternative splicing isoforms for
DPY30

Expression for DPY30 Gene

mRNA expression in normal human tissues for DPY30 Gene

Protein differential expression in normal tissues from HIPED for DPY30 Gene

This gene is overexpressed in Bone (9.0), Fetal Brain (8.4), and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPY30 Gene



SOURCE GeneReport for Unigene cluster for DPY30 Gene Hs.531788

genes like me logo Genes that share expression patterns with DPY30: view

Protein tissue co-expression partners for DPY30 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPY30 Gene

Orthologs for DPY30 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPY30 35
  • 94.95 (n)
  • 100 (a)
DPY30 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPY30 35
  • 95.29 (n)
  • 98.99 (a)
DPY30 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpy30 35
  • 92.59 (n)
  • 97.98 (a)
Dpy30 16
Dpy30 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPY30 35
  • 100 (n)
  • 100 (a)
DPY30 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpy30 35
  • 93.6 (n)
  • 97.98 (a)
oppossum
(Monodelphis domestica)
Mammalia DPY30 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPY30 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPY30 35
  • 84.18 (n)
  • 89.9 (a)
DPY30 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPY30 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpy30 35
  • 75.42 (n)
  • 81.82 (a)
Str.1272 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8175 35
zebrafish
(Danio rerio)
Actinopterygii dpy30 35
  • 71.01 (n)
  • 80.43 (a)
dpy30 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dpy-30L1 36
  • 26 (a)
OneToMany
Dpy-30L2 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-30 36
  • 28 (a)
OneToOne
Species with no ortholog for DPY30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPY30 Gene

ENSEMBL:
Gene Tree for DPY30 (if available)
TreeFam:
Gene Tree for DPY30 (if available)

Paralogs for DPY30 Gene

(2) SIMAP similar genes for DPY30 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DPY30 Gene

genes like me logo Genes that share paralogs with DPY30: view

No data available for Paralogs for DPY30 Gene

Variants for DPY30 Gene

Sequence variations from dbSNP and Humsavar for DPY30 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs486754 -- 32,031,369(+) gagcc(A/G)agatc intron-variant
rs490226 -- 32,041,137(+) gtgtg(G/T)gggcg upstream-variant-2KB
rs502824 -- 32,034,526(+) catga(A/G)ggatt intron-variant
rs559693 -- 32,026,720(+) gaggc(A/G)gaggt intron-variant
rs591625 -- 32,030,456(-) agatg(A/G)ggttt intron-variant

Variation tolerance for DPY30 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPY30 Gene

HapMap Linkage Disequilibrium report
DPY30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DPY30 Gene

Disorders for DPY30 Gene

Relevant External Links for DPY30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPY30

No disorders were found for DPY30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPY30 Gene

Publications for DPY30 Gene

  1. Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex. (PMID: 19481096) Wang X. … Rao Z. (J. Mol. Biol. 2009) 3 4 23 67
  2. Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex. (PMID: 16260194) Dong X. … Rao Z. (Biochim. Biophys. Acta 2005) 2 3 23
  3. DPY30 regulates pathways in cellular senescence through ID protein expression. (PMID: 23872946) Simboeck E. … Di Croce L. (EMBO J. 2013) 2 3
  4. Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation. (PMID: 25542209) Zhang H. … Chang W. (Protein Cell 2015) 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for DPY30 Gene

Sources for DPY30 Gene

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