Aliases for DPY30 Gene
External Ids for DPY30 Gene
Previous GeneCards Identifiers for DPY30 Gene
This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]
GeneCards Summary for DPY30 Gene
DPY30 (Dpy-30, Histone Methyltransferase Complex Regulatory Subunit) is a Protein Coding gene. Among its related pathways are Chromatin organization and PKMTs methylate histone lysines. GO annotations related to this gene include protein homodimerization activity and identical protein binding.
UniProtKB/Swiss-Prot for DPY30 Gene
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at Lys-4, particularly trimethylation. Histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 Lys-4 methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.