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DPY19L4 Gene

protein-coding   GIFtS: 45
GCID: GC08P095802

Dpy-19-Like 4 (C. Elegans)

  Search for DPY19L4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dpy-19-Like 4 (C. Elegans)1 2
Dpy-19-Like Protein 42 3
Protein Dpy-19 Homolog 42 3
Probable C-Mannosyltransferase DPY19L42
EC 2.4.1.-3

External Ids:    HGNC: 278291   Entrez Gene: 2861482   Ensembl: ENSG000001561627   OMIM: 6138955   UniProtKB: Q7Z3883   

Export aliases for DPY19L4 gene to outside databases

Previous GC identifer: GC08P090940


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DPY19L4 Gene:
DPY19L4 (dpy-19-like 4 (C. elegans)) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is DPY19L3.

UniProtKB/Swiss-Prot: D19L4_HUMAN, Q7Z388
Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPY19L4 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CREB   E2F   E2F-1   FOXJ2 (long isoform)   deltaCREB   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPY19L4 promoter sequence
   Search Chromatin IP Primers for DPY19L4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPY19L4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

DPY19L4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPY19L4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P095802:  view genomic region     (about GC identifiers)

Start:
95,731,931 bp from pter      End:
95,806,076 bp from pter
Size:
74,146 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: D19L4_HUMAN, Q7Z388 (See protein sequence)
Recommended Name: Probable C-mannosyltransferase DPY19L4  
Size: 723 amino acids; 83756 Da
Sequence caution: Sequence=BAC85664.1; Type=Erroneous initiation;
Secondary accessions: Q6ZW32 Q6ZW42 Q7Z329

Explore the universe of human proteins at neXtProt for DPY19L4: NX_Q7Z388

Explore proteomics data for DPY19L4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DPY19L4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_861452.2  
    ENSEMBL proteins: 
     ENSP00000428762   ENSP00000430162   ENSP00000389630   ENSP00000428041   ENSP00000430417  
     ENSP00000429559   ENSP00000429785   ENSP00000429711  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018732 Dpy-19

    Graphical View of Domain Structure for InterPro Entry Q7Z388

    ProtoNet protein and cluster: Q7Z388

    UniProtKB/Swiss-Prot: D19L4_HUMAN, Q7Z388
    Similarity: Belongs to the dpy-19 family


    DPY19L4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: D19L4_HUMAN, Q7Z388
    Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
    (By similarity)

         Enzyme Number (IUBMB): EC 2.4.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016757transferase activity, transferring glycosyl groups IEA--
         
    DPY19L4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPY19L4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPY19L4
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    miRNA
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    miRTarBase miRNAs that target DPY19L4:
    hsa-mir-20a-5p (MIRT050523), hsa-mir-100-5p (MIRT048489)

    Block miRNA regulation of human, mouse, rat DPY19L4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPY19L4 (see all 38):
    hsa-miR-607 hsa-miR-15a hsa-miR-374a* hsa-miR-124 hsa-miR-424 hsa-miR-3613-3p hsa-miR-506 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidDPY19L4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat DPY19L4

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPY19L4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    D19L4_HUMAN, Q7Z388: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    peroxisome2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    DPY19L4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPY19L4
    Interactions:

        Search GeneGlobe Interaction Network for DPY19L4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DPY19L4 (ENSP000003896304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPY19L4 (D19L4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DPY19L4 gene: 
    NM_181787.2  

    Unigene Cluster for DPY19L4:

    Dpy-19-like 4 (C. elegans)
    Hs.567828  [show with all ESTs]
    Unigene Representative Sequence: NM_181787
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522422 ENST00000520774 ENST00000414645(uc003ygx.2) ENST00000519353
    ENST00000519176(uc003ygy.3) ENST00000521525 ENST00000523020 ENST00000522669

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DPY19L4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPY19L4 (see all 38):
    hsa-miR-607 hsa-miR-15a hsa-miR-374a* hsa-miR-124 hsa-miR-424 hsa-miR-3613-3p hsa-miR-506 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidDPY19L4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DPY19L4
    Predesigned siRNA for gene silencing in human, mouse, rat DPY19L4
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    GenScript: all cDNA clones in your preferred vector: DPY19L4 (NM_181787)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPY19L4
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      QuantiTect SYBR Green Assays in human, mouse, rat DPY19L4
      QuantiFast Probe-based Assays in human, mouse, rat DPY19L4

    Additional mRNA sequence: 

    AF086017.1 AK123618.1 AK123682.1 AL049962.1 AL832859.1 BC038568.1 BC042810.1 BC050303.1 
    BC110870.1 BC126193.1 BC130576.1 BX538048.1 BX538174.1 

    12 DOTS entries:

    DT.100023257  DT.311351  DT.100792636  DT.40130936  DT.100023258  DT.92008467  DT.100792638  DT.91711690 
    DT.92060037  DT.95153004  DT.95335579  DT.121479520 

    Selected AceView cDNA sequences (see all 129):

    AI742536 AF086017 BI491105 BX279787 AW044648 AA405180 CA405982 BC038568 
    CB045108 AK123682 BG771314 BU178659 CA335273 BU156473 BX500149 AK123618 
    AI927464 BE349999 BM852613 H88211 AI924863 AA747553 AW517711 AA179072 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                        -     -     -                                                                                 
    SP2:                                                        -                                                                                             
    SP3:                    -     -     -                                                                                                                     
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for DPY19L4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPY19L4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DPY19L4 Expression
    About this image

    DPY19L4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPY19L4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567828

    UniProtKB/Swiss-Prot: D19L4_HUMAN, Q7Z388
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPY19L4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpy19l41 , 5 dpy-19-like 4 (C. elegans)1, 5 86.8(n)1
    88.64(a)1
      4 (5.11 cM)5
    3815101  NM_001081201.11  NP_001074670.11 
     112613155 
    chicken
    (Gallus gallus)
    Aves DPY19L41 dpy-19-like 4 (C. elegans) 79.04(n)
    83.75(a)
      420229  XM_418339.4  XP_418339.4 
    lizard
    (Anolis carolinensis)
    Reptilia DPY19L46
    dpy-19-like 4 (C. elegans)
    75(a)
    1 ↔ 1
    4(19208299-19239286)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.166492 Transcribed sequences 74.95(n)    AL876127.2 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii BX078033.12   -- 71.13(n)    BX078033.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66596
    --
    15(a)
    1 → many
    X(18547425-18551319)


    ENSEMBL Gene Tree for DPY19L4 (if available)
    TreeFam Gene Tree for DPY19L4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPY19L4 gene
    DPY19L32  DPY19L22  DPY19L12  
    1 SIMAP similar gene for DPY19L4 using alignment to 8 protein entries:     D19L4_HUMAN (see all proteins):
    DPY19L3

    DPY19L4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DPY19L4
    PGOHUM00000244548 PGOHUM00000233633


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPY19L4 (see all 1543)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849418131,2
    --95730139(+) CTCGAA/TCTCCT 1 -- us2k10--------
    rs1873925881,2
    --95730270(+) TAATTA/CTCTCT 1 -- us2k10--------
    rs2002774411,2
    C--95730275(+) ATCTC-/TATCT 
            
    TATCT
    1 -- us2k10--------
    rs1118252451,2
    F--95730287(+) TCTTAT/GATTTC 1 -- us2k12Minor allele frequency- G:0.02CSA WA 120
    rs1929428691,2
    --95730320(+) TTTTTA/TTTCTA 1 -- us2k10--------
    rs1503863761,2
    --95730474(+) TTTCCA/TAGAGG 1 -- us2k10--------
    rs789816081,2
    C,F--95730608(+) CACCAG/AGCCTT 1 -- us2k12Minor allele frequency- A:0.08NA EA 240
    rs1380849891,2
    --95730626(+) CCACTC/GTTTCT 1 -- us2k10--------
    rs1847990731,2
    --95730684(+) AACCAG/TACATA 1 -- us2k10--------
    rs1897243871,2
    --95730774(+) TTGAGC/GTCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPY19L4 (95731931 - 95806076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DPY19L4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674010CNV Deletion23128226
    esv2657874CNV Deletion23128226
    esv271096CNV Insertion20981092
    nsv511392CNV Loss21212237

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPY19L4
    DNA2.0 Custom Variant and Variant Library Synthesis for DPY19L4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613895    OMIM disorders: --


    DPY19L4 for disorders           About GeneDecksing


    Export disorders for DPY19L4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPY19L4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DPY19L4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    3. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. Distinct class of putative &quot;non-conserved&quot; promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (Genome Res. 2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    9. Duplication and relocation of the functional DPY19L2 gene within low copy repeats. (PubMed id 16526957)2 Carson A.R.... Scherer S.W. (BMC Genomics 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286148 HGNC: 27829 AceView: LOC286148 Ensembl:ENSG00000156162 euGenes: HUgn286148
    ECgene: DPY19L4 H-InvDB: DPY19L4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPY19L4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for DPY19L4 gene:
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