DPY19L4 Gene
protein-coding GIFtS: 44
GCID: GC08P095802
|
|
dpy-19-like 4 (C. elegans)
| |
Aliases
for DPY19L4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dpy-19-Like 4 (C. Elegans)1 2 | | Dpy-19-Like Protein 42 3 | | Protein Dpy-19 Homolog 42 |
Export aliases for DPY19L4 gene to outside databasesPrevious GC identifer: GC08P090940 |
Summaries
for DPY19L4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DPY19L4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DPY19L4 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 CREB E2F E2F-1 FOXJ2 (long isoform) deltaCREB FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DPY19L4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPY19L4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1DPY19L4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P095802: view genomic region
(about GC identifiers)
Start:
|
95,731,931 bp from pter |
End:
|
95,806,076 bp from pter |
Size:
|
74,146 bases |
Orientation:
|
plus strand |
|
Proteins
for DPY19L4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: D19L4_HUMAN, Q7Z388 (See
protein sequence)Recommended Name: Protein dpy-19 homolog 4 Size: 723 amino acids; 83756 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC85664.1; Type=Erroneous initiation;
Secondary accessions: Q6ZW32 Q6ZW42 Q7Z329Explore the universe of human proteins at neXtProt for DPY19L4: NX_Q7Z388
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z388
DPY19L4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_861452.2
ENSEMBL proteins: ENSP00000428762 ENSP00000430162 ENSP00000389630 ENSP00000428041 ENSP00000430417 ENSP00000429559 ENSP00000429785 ENSP00000429711
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
DPY19L4 for ontologies About GeneDecksing
DPY19L4 Antibody Products:
Assay Products for DPY19L4: |
Protein
Domains /
Families
for DPY19L4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPY19L4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z388ProtoNet protein and cluster: Q7Z388 UniProtKB/Swiss-Prot: D19L4_HUMAN, Q7Z388Similarity: Belongs to the dpy-19 family |
Function
for DPY19L4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPY19L4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPY19L4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPY19L4 |
|
Pathways & Interactions
for DPY19L4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPY19L4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DPY19L4 (ENSP000003896304) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DPY19L4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DPY19L4
Search CenterWatch for drugs/clinical trials and news about DPY19L4 / D19L4
|
Transcripts
for DPY19L4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DPY19L4 gene: NM_181787.2 Unigene Cluster for DPY19L4: Dpy-19-like 4 (C. elegans) Hs.567828 [show with all ESTs]Unigene Representative Sequence: NM_1817878 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522422 ENST00000520774 ENST00000414645(uc003ygx.2) ENST00000519353
ENST00000519176(uc003ygy.3) ENST00000521525 ENST00000523020 ENST00000522669
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPY19L4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPY19L4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DPY19L4 (NM_181787) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPY19L4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPY19L4 |
Additional cDNA sequence: AF086017.1 AK123618.1 AK123682.1 AL049962.1 AL832859.1 BC038568.1 BC042810.1 BC050303.1 BC110870.1 BC126193.1 BC130576.1 BX538048.1 BX538174.1 12 DOTS entries: DT.100023257 DT.311351 DT.100792636 DT.40130936 DT.100023258 DT.92008467 DT.100792638 DT.91711690 DT.92060037 DT.95153004 DT.95335579 DT.121479520 24/129 AceView cDNA sequences (see all 129): CA335273 BX538174 AA640191 AA179072 AW517711 BM852613 BX279787 BU156473 AW044648 BU618522 AK123682 BC038568 NM_181787 BX500149 BG771314 BE349999 AI742536 AF086017 AI927464 AA747553 AI669947 BX538048 Z33547 AI888220
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DPY19L4
|
Expression
for DPY19L4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPY19L4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DPY19L4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPY19L4
SOURCE GeneReport for Unigene cluster: Hs.567828
UniProtKB/Swiss-Prot: D19L4_HUMAN, Q7Z388Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for DPY19L4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPY19L4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPY19L4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPY19L4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPY19L4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPY19L4 |
Orthologs
for DPY19L4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DPY19L4 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DPY19L41 |
dpy-19-like 4 (C. elegans) |
79.04(n)
83.75(a) |
|
420229 XM_418339.3 XP_418339.3 |
lizard
(Anolis carolinensis) |
Reptilia |
DPY19L46 |
-- |
75(a) |
1 ↔ 1 |
4(19214939-19235074) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.166492 |
Transcribed sequences |
74.95(n) |
|
AL876127.2 |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
BX078033.12 |
-- |
71.13(n) |
|
BX078033.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG66596 |
-- |
14(a) |
1 → many |
X(18547425-18551319) |
ENSEMBL Gene Tree for DPY19L4 (if available)
TreeFam Gene Tree for DPY19L4 (if available) |
Paralogs
for DPY19L4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DPY19L4 gene
- DPY19L32 DPY19L22 DPY19L12
1 SIMAP similar gene for DPY19L4 using alignment to 8 protein entries: D19L4_HUMAN (see all proteins):DPY19L3
DPY19L4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for DPY19L4
PGOHUM00000244548 PGOHUM00000233633
|
Genomic Variants
for DPY19L4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DPY19L4 (95731931 - 95806076 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for DPY19L4
6 Indels: 82688 82691 82689 95573 95574 82690 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPY19L4 |
|
Disorders
/ Diseases
for DPY19L4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPY19L4 for disorders About GeneDecksing
OMIM gene information: 613895
OMIM disorders: --
1  disease for DPY19L4: About MalaCardsmalaria
Export disorders for DPY19L4 gene to outside databases
|
Publications
for DPY19L4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPY19L4 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with DPY19L4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Duplication and relocation of the functional DPY19L2 gene within low copy repeats. (PubMed id 16526957)2 Carson A.R.... Scherer S.W. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
|
External Searches for DPY19L4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DPY19L4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DPY19L4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DPY19L4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DPY19L4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DPY19L4 gene:
Search GeneIP for patents involving DPY19L4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DPY19L4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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