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Aliases for DPY19L3 Gene

Aliases for DPY19L3 Gene

  • Dpy-19-Like 3 (C. Elegans) 2 3
  • Protein Dpy-19 Homolog 3 4
  • Dpy-19-Like Protein 3 4
  • EC 2.4.1.- 4

External Ids for DPY19L3 Gene

Previous GeneCards Identifiers for DPY19L3 Gene

  • GC19P037591
  • GC19P032897
  • GC19P029399

Summaries for DPY19L3 Gene

GeneCards Summary for DPY19L3 Gene

DPY19L3 (Dpy-19-Like 3 (C. Elegans)) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is DPY19L2.

UniProtKB/Swiss-Prot for DPY19L3 Gene

  • Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPY19L3 Gene

Genomics for DPY19L3 Gene

Regulatory Elements for DPY19L3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPY19L3 Gene

Start:
32,405,543 bp from pter
End:
32,485,895 bp from pter
Size:
80,353 bases
Orientation:
Plus strand

Genomic View for DPY19L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPY19L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY19L3 Gene

Proteins for DPY19L3 Gene

  • Protein details for DPY19L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZPD9-D19L3_HUMAN
    Recommended name:
    Probable C-mannosyltransferase DPY19L3
    Protein Accession:
    Q6ZPD9
    Secondary Accessions:
    • Q68DC7
    • Q6ZTB7
    • Q6ZTS2

    Protein attributes for DPY19L3 Gene

    Size:
    716 amino acids
    Molecular mass:
    83197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86508.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DPY19L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPY19L3 Gene

Proteomics data for DPY19L3 Gene at MOPED

Post-translational modifications for DPY19L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPY19L3 Gene

No data available for DME Specific Peptides for DPY19L3 Gene

Domains for DPY19L3 Gene

Protein Domains for DPY19L3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPY19L3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZPD9

UniProtKB/Swiss-Prot:

D19L3_HUMAN :
  • Q6ZPD9
Family:
  • Belongs to the dpy-19 family.
genes like me logo Genes that share domains with DPY19L3: view

No data available for Gene Families for DPY19L3 Gene

Function for DPY19L3 Gene

Molecular function for DPY19L3 Gene

UniProtKB/Swiss-Prot Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Enzyme Numbers (IUBMB) for DPY19L3 Gene

Gene Ontology (GO) - Molecular Function for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA --
GO:0016757 transferase activity, transferring glycosyl groups --
genes like me logo Genes that share ontologies with DPY19L3: view

Phenotypes for DPY19L3 Gene

genes like me logo Genes that share phenotypes with DPY19L3: view

Animal Model Products

CRISPR Products

miRNA for DPY19L3 Gene

miRTarBase miRNAs that target DPY19L3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPY19L3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DPY19L3 Gene

Localization for DPY19L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY19L3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPY19L3 Gene COMPARTMENTS Subcellular localization image for DPY19L3 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPY19L3: view

Pathways for DPY19L3 Gene

SuperPathways for DPY19L3 Gene

No Data Available

Interacting Proteins for DPY19L3 Gene

Gene Ontology (GO) - Biological Process for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018406 protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan IBA --
genes like me logo Genes that share ontologies with DPY19L3: view

No data available for Pathways by source for DPY19L3 Gene

Transcripts for DPY19L3 Gene

Unigene Clusters for DPY19L3 Gene

Dpy-19-like 3 (C. elegans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPY19L3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DPY19L3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4: -
SP5: - -
SP6: - -
SP7: -
SP8:

ExUns: 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for DPY19L3 Gene

GeneLoc Exon Structure for
DPY19L3
ECgene alternative splicing isoforms for
DPY19L3

Expression for DPY19L3 Gene

mRNA expression in normal human tissues for DPY19L3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DPY19L3 Gene

SOURCE GeneReport for Unigene cluster for DPY19L3 Gene Hs.194392

mRNA Expression by UniProt/SwissProt for DPY19L3 Gene

Q6ZPD9-D19L3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with DPY19L3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DPY19L3 Gene

Orthologs for DPY19L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY19L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPY19L3 35
  • 99.58 (n)
  • 99.86 (a)
DPY19L3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPY19L3 35
  • 91.34 (n)
  • 92.32 (a)
DPY19L3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPY19L3 35
  • 90.83 (n)
  • 93.3 (a)
DPY19L3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpy19l3 35
  • 84.36 (n)
  • 87.71 (a)
Dpy19l3 16
Dpy19l3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPY19L3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPY19L3 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpy19l3 35
  • 84.22 (n)
  • 88.27 (a)
chicken
(Gallus gallus)
Aves DPY19L3 35
  • 73.62 (n)
  • 75.77 (a)
DPY19L3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPY19L3 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8176 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dpy19l3 35
  • 67.61 (n)
  • 68.25 (a)
Str.17229 35
zebrafish
(Danio rerio)
Actinopterygii dpy19l3 35
  • 63.43 (n)
  • 63.94 (a)
DPY19L3 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6659 36
  • 16 (a)
OneToMany
Species with no ortholog for DPY19L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPY19L3 Gene

ENSEMBL:
Gene Tree for DPY19L3 (if available)
TreeFam:
Gene Tree for DPY19L3 (if available)

Paralogs for DPY19L3 Gene

Paralogs for DPY19L3 Gene

Selected SIMAP similar genes for DPY19L3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DPY19L3 Gene

genes like me logo Genes that share paralogs with DPY19L3: view

Variants for DPY19L3 Gene

Sequence variations from dbSNP and Humsavar for DPY19L3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs375752 -- 32,450,920(+) CAGTA(A/G)TTGTA intron-variant
rs414898 -- 32,447,475(+) acttt(C/G)ggagg intron-variant
rs723935 -- 32,466,530(+) AGCAC(C/G)TCTCC intron-variant
rs738093 -- 32,439,601(+) ATGCA(A/G)AGTGT intron-variant
rs741441 -- 32,408,168(-) CAACA(C/T)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPY19L3 Gene

Variant ID Type Subtype PubMed ID
nsv510471 CNV Loss 20534489

Relevant External Links for DPY19L3 Gene

HapMap Linkage Disequilibrium report
DPY19L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPY19L3 Gene

Disorders for DPY19L3 Gene

Relevant External Links for DPY19L3

Genetic Association Database (GAD)
DPY19L3
Human Genome Epidemiology (HuGE) Navigator
DPY19L3
genes like me logo Genes that share disorders with DPY19L3: view

No data available for UniProtKB/Swiss-Prot for DPY19L3 Gene

Publications for DPY19L3 Gene

  1. Genome-wide association study of bipolar disorder in European American and African American individuals. (PMID: 19488044) Smith E.N. … Kelsoe J.R. (Mol. Psychiatry 2009) 3 48
  2. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Duplication and relocation of the functional DPY19L2 gene within low copy repeats. (PMID: 16526957) Carson A.R. … Scherer S.W. (BMC Genomics 2006) 4

Products for DPY19L3 Gene

Sources for DPY19L3 Gene

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