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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPY19L3 Gene

protein-coding   GIFtS: 46
GCID: GC19P032897

Dpy-19-Like 3 (C. Elegans)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dpy-19-Like 3 (C. Elegans)1 2
Dpy-19-Like Protein 32 3
Protein Dpy-19 Homolog 32 3
Probable C-Mannosyltransferase DPY19L32
EC 2.4.1.-3

External Ids:    HGNC: 271201   Entrez Gene: 1479912   Ensembl: ENSG000001789047   OMIM: 6138945   UniProtKB: Q6ZPD93   

Export aliases for DPY19L3 gene to outside databases

Previous GC identifers: GC19P037591 GC19P029399


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DPY19L3 Gene: 
DPY19L3 (dpy-19-like 3 (C. elegans)) is a protein-coding gene. Diseases associated with DPY19L3 include bipolar disorder. An important paralog of this gene is DPY19L4.

UniProtKB/Swiss-Prot: D19L3_HUMAN, Q6ZPD9
Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPY19L3 gene promoter:
         HFH-3   AP-1   LCR-F1   FOXI1   S8   POU2F1   POU2F1a   Pax-4a   TGIF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DPY19L3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPY19L3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPY19L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

DPY19L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPY19L3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P032897:  view genomic region     (about GC identifiers)

Start:
32,896,655 bp from pter      End:
32,976,801 bp from pter
Size:
80,147 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: D19L3_HUMAN, Q6ZPD9 (See protein sequence)
Recommended Name: Probable C-mannosyltransferase DPY19L3  
Size: 716 amino acids; 83197 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC86508.1; Type=Erroneous initiation;
Secondary accessions: Q68DC7 Q6ZTB7 Q6ZTS2
Alternative splicing: 2 isoforms:  Q6ZPD9-1   Q6ZPD9-2   

Explore the universe of human proteins at neXtProt for DPY19L3: NX_Q6ZPD9

Explore proteomics data for DPY19L3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZPD9

  • DPY19L3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPY19L3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001166245.1  NP_997208.2  

    ENSEMBL proteins: 
     ENSP00000465995   ENSP00000466086   ENSP00000344937   ENSP00000466062   ENSP00000465997  
     ENSP00000474174   ENSP00000376081  

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    Cloud-Clone Corp. Proteins for DPY19L3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    DPY19L3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018732 Dpy-19

    Graphical View of Domain Structure for InterPro Entry Q6ZPD9

    ProtoNet protein and cluster: Q6ZPD9

    UniProtKB/Swiss-Prot: D19L3_HUMAN, Q6ZPD9
    Similarity: Belongs to the dpy-19 family


    DPY19L3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: D19L3_HUMAN, Q6ZPD9
    Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
    (By similarity)

         Enzyme Number (IUBMB): EC 2.4.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016757transferase activity, transferring glycosyl groups IEA--
         
    DPY19L3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dpy19l3):
     hematopoietic system  limbs/digits/tail  vision/eye 

    DPY19L3 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPY19L3 
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    miRNA
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate DPY19L3 (see all 60):
    hsa-miR-2052 hsa-miR-3607-3p hsa-miR-607 hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-218 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidDPY19L3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPY19L3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPY19L3 (D19L3)

    Search CenterWatch for drugs/clinical trials and news about DPY19L3 / D19L3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPY19L3 gene (2 alternative transcripts): 
    NM_001172774.1  NM_207325.2  

    Unigene Cluster for DPY19L3:

    Dpy-19-like 3 (C. elegans)
    Hs.194392  [show with all ESTs]
    Unigene Representative Sequence: NM_207325
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592503 ENST00000587077 ENST00000586987 ENST00000342179(uc002nth.2)
    ENST00000586427 ENST00000585597 ENST00000588648 ENST00000592142 ENST00000592832
    ENST00000590651 ENST00000392250(uc002ntf.3 uc002ntg.3 uc002nti.2 uc002ntj.2)

    miRNA
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate DPY19L3 (see all 60):
    hsa-miR-2052 hsa-miR-3607-3p hsa-miR-607 hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-218 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidDPY19L3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPY19L3
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    Additional mRNA sequence: 

    AF533710.1 AF533711.1 AK024775.1 AK055227.1 AK125486.1 AK125846.1 AK126264.1 AK126757.1 
    AK129497.1 AL833713.1 BC029162.1 BC131725.1 CR749459.1 

    11 DOTS entries:

    DT.112501  DT.91974040  DT.86843611  DT.95079712  DT.95112323  DT.101983524  DT.99998267  DT.102831788 
    DT.121445456  DT.91979359  DT.102831787 

    24/97 AceView cDNA sequences (see all 97):

    T95943 AL157591 AI568650 BQ007126 AW197099 NM_207325 AA305955 AI685558 
    AL833713 CF541228 AI720220 AL157566 AK126757 AA336737 BF057717 BQ716237 
    AA449197 BM996188 AI379656 AA830856 AI038965 CD109630 AK125486 CB988307 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                    -                 -     -                             -                                                                 -               
    SP2:                                      -     -                             -                                                                 -               
    SP3:                                                                                                                                                            
    SP4:                                                                          -                                                                                 
    SP5:                                                                                                                                      -     -               

    ExUns: 21a · 21b · 21c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for DPY19L3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPY19L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAAAGCT
    DPY19L3 Expression
    About this image


    See DPY19L3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPY19L3

    SOURCE GeneReport for Unigene cluster: Hs.194392

    UniProtKB/Swiss-Prot: D19L3_HUMAN, Q6ZPD9
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DPY19L3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpy19l31 , 5 dpy-19-like 3 (C. elegans)1, 5 84.36(n)1
    87.71(a)1
      7 (21.37 cM)5
    2331151  NM_178704.31  NP_848819.21 
     356851655 
    chicken
    (Gallus gallus)
    Aves DPY19L31 dpy-19-like 3 (C. elegans) 73.62(n)
    75.77(a)
      768782  XM_001231904.2  XP_001231905.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPY19L36
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343295.1(1565049-1600242)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81762 Xenopus laevis transcribed sequence with weak similarity more 77.13(n)    48061178 
    zebrafish
    (Danio rerio)
    Actinopterygii dpy19l31 dpy-19-like 3 (C. elegans) 63.43(n)
    63.94(a)
      796987  XM_001337368.3  XP_001337404.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66596
    --
    16(a)
    1 → many
    X(18547425-18551319)


    ENSEMBL Gene Tree for DPY19L3 (if available)
    TreeFam Gene Tree for DPY19L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPY19L3 gene
    DPY19L42  DPY19L22  DPY19L12  
    3 SIMAP similar genes for DPY19L3 using alignment to 5 protein entries:     D19L3_HUMAN (see all proteins):
    DPY19L4    DPY19L2    DPY19L1

    DPY19L3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DPY19L3
    PGOHUM00000258539


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1582 SNPs in DPY19L3 are shown (see all 1582)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713352001,2
    C--29416589(+) AAAAA-/CACA  
     
    /CACACA
    CACAC
    4 -- int1 cds11NA 2
    rs713352021,2
    C--29435469(+) GTCTC-/T/TTT 
            
    TTTTT
    2 -- int11NA 2
    rs1387331791,2
    --32898465(+) GTTACA/GTGACG 2 -- int10--------
    rs1880184121,2
    --32898485(+) GTAACC/TGCTAT 2 -- int10--------
    rs752416511,2
    C,F--32898493(+) TATGGC/TTCAGG 2 -- int12Minor allele frequency- T:0.07WA EA 238
    rs19783831,2
    C,F--32898618(+) ACATGC/TTTCAT 2 -- int12Minor allele frequency- T:0.08WA EA 238
    rs19783841,2
    C,F,H--32898686(+) AGGCCA/GGCAAC 2 -- int121Minor allele frequency- G:0.07NS EA NA WA 2648
    rs1912771161,2
    --32898735(+) GGCTCA/GTTCAT 2 -- int10--------
    rs1838747051,2
    --32898887(+) TACTCA/GGGAGG 2 -- int10--------
    rs1884907261,2
    --32898954(+) CCGCTA/GCACTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for DPY19L3 (32896655 - 32976801 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DPY19L3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510471CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613894    OMIM disorders: --

    2 diseases for DPY19L3:    About MalaCards
    bipolar disorder    


    DPY19L3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DPY19L3
    Human Genome Epidemiology (HuGE) Navigator: DPY19L3 (1 document)

    Export disorders for DPY19L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPY19L3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DPY19L3)
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    1. Genome-wide association study of bipolar disorder in European American and African American individuals. (PubMed id 19488044)1, 4 Smith E.N....Kelsoe J.R. (2009)
    2. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Duplication and relocation of the functional DPY19L2 gene within low copy repeats. (PubMed id 16526957)2 Carson A.R.... Scherer S.W. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147991 HGNC: 27120 AceView: LOC147991 Ensembl:ENSG00000178904 euGenes: HUgn147991
    ECgene: DPY19L3 H-InvDB: DPY19L3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPY19L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPY19L3 gene:
    Search GeneIP for patents involving DPY19L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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