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Aliases for DPY19L3 Gene

Aliases for DPY19L3 Gene

  • Dpy-19 Like 3 (C. Elegans) 2 3 5
  • Protein Dpy-19 Homolog 3 4
  • Dpy-19-Like Protein 3 4
  • EC 2.4.1.- 4

External Ids for DPY19L3 Gene

Previous GeneCards Identifiers for DPY19L3 Gene

  • GC19P037591
  • GC19P032897
  • GC19P029399

Summaries for DPY19L3 Gene

GeneCards Summary for DPY19L3 Gene

DPY19L3 (Dpy-19 Like 3 (C. Elegans)) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity. An important paralog of this gene is DPY19L4.

UniProtKB/Swiss-Prot for DPY19L3 Gene

  • Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPY19L3 Gene

Genomics for DPY19L3 Gene

Regulatory Elements for DPY19L3 Gene

Enhancers for DPY19L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F032370 1.5 FANTOM5 Ensembl ENCODE 17.4 -31.7 -31671 5.8 PKNOX1 ARNT MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416 GPATCH1 ZNF507 DPY19L3 FAAP24 LOC400684 GC19M032380
GH19F032421 0.8 Ensembl ENCODE 13.2 +16.6 16558 1.8 TBP HDAC1 ATF1 PKNOX1 CBX3 TBL1XR1 NFRKB CHAMP1 ELK1 GATA2 DPY19L3 LOC400684 ZNF507 GC19M032466
GH19F032362 1 ENCODE 11.7 -42.3 -42276 2.4 PKNOX1 ARID4B SIN3A YY1 ZHX2 PPARG KAT8 MIER3 RCOR2 KDM1A DPY19L3 LOC400684 ZNF507 GC19M032380
GH19F032336 1.1 Ensembl ENCODE 11.7 -68.3 -68343 1.5 RAD21 RARA CREM ZNF654 CEBPB ATF4 KLF16 CEBPA KDM1A ZNF785 DPY19L3 PDCD5 ZNF507 GC19M032297
GH19F032572 0.4 Ensembl 9.7 +167.5 167458 0.4 PKNOX1 KLF17 SIN3A FEZF1 ZNF2 ZEB1 ZNF335 ZNF121 GLIS2 ZNF366 PDCD5 ENSG00000201388 DPY19L3 GC19P032471
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DPY19L3 on UCSC Golden Path with GeneCards custom track

Promoters for DPY19L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418793 557 2601 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF143

Genomic Location for DPY19L3 Gene

Chromosome:
19
Start:
32,405,543 bp from pter
End:
32,485,895 bp from pter
Size:
80,353 bases
Orientation:
Plus strand

Genomic View for DPY19L3 Gene

Genes around DPY19L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPY19L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPY19L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY19L3 Gene

Proteins for DPY19L3 Gene

  • Protein details for DPY19L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZPD9-D19L3_HUMAN
    Recommended name:
    Probable C-mannosyltransferase DPY19L3
    Protein Accession:
    Q6ZPD9
    Secondary Accessions:
    • Q68DC7
    • Q6ZTB7
    • Q6ZTS2

    Protein attributes for DPY19L3 Gene

    Size:
    716 amino acids
    Molecular mass:
    83197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86508.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DPY19L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPY19L3 Gene

Post-translational modifications for DPY19L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DPY19L3 Gene

Domains & Families for DPY19L3 Gene

Protein Domains for DPY19L3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPY19L3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZPD9

UniProtKB/Swiss-Prot:

D19L3_HUMAN :
  • Belongs to the dpy-19 family.
Family:
  • Belongs to the dpy-19 family.
genes like me logo Genes that share domains with DPY19L3: view

No data available for Gene Families for DPY19L3 Gene

Function for DPY19L3 Gene

Molecular function for DPY19L3 Gene

UniProtKB/Swiss-Prot Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Enzyme Numbers (IUBMB) for DPY19L3 Gene

Gene Ontology (GO) - Molecular Function for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with DPY19L3: view
genes like me logo Genes that share phenotypes with DPY19L3: view

Animal Models for DPY19L3 Gene

MGI Knock Outs for DPY19L3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPY19L3 Gene

Localization for DPY19L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY19L3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPY19L3 Gene COMPARTMENTS Subcellular localization image for DPY19L3 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPY19L3: view

Pathways & Interactions for DPY19L3 Gene

SuperPathways for DPY19L3 Gene

No Data Available

Interacting Proteins for DPY19L3 Gene

Selected Interacting proteins: Q6ZPD9-D19L3_HUMAN for DPY19L3 Gene via IID

Gene Ontology (GO) - Biological Process for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018406 protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan IBA --
genes like me logo Genes that share ontologies with DPY19L3: view

No data available for Pathways by source and SIGNOR curated interactions for DPY19L3 Gene

Transcripts for DPY19L3 Gene

Unigene Clusters for DPY19L3 Gene

Dpy-19-like 3 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4: -
SP5: - -
SP6: - -
SP7: -
SP8:

ExUns: 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for DPY19L3 Gene

GeneLoc Exon Structure for
DPY19L3
ECgene alternative splicing isoforms for
DPY19L3

Expression for DPY19L3 Gene

mRNA expression in normal human tissues for DPY19L3 Gene

Protein differential expression in normal tissues from HIPED for DPY19L3 Gene

This gene is overexpressed in Testis (13.2), Adrenal (11.3), Ovary (10.7), and Fetal Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPY19L3 Gene



Protein tissue co-expression partners for DPY19L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of DPY19L3 Gene:

DPY19L3

SOURCE GeneReport for Unigene cluster for DPY19L3 Gene:

Hs.194392

mRNA Expression by UniProt/SwissProt for DPY19L3 Gene:

Q6ZPD9-D19L3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with DPY19L3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DPY19L3 Gene

Orthologs for DPY19L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY19L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPY19L3 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia DPY19L3 34 35
  • 91.34 (n)
dog
(Canis familiaris)
Mammalia DPY19L3 34 35
  • 90.83 (n)
mouse
(Mus musculus)
Mammalia Dpy19l3 34 16 35
  • 84.36 (n)
rat
(Rattus norvegicus)
Mammalia Dpy19l3 34
  • 84.22 (n)
oppossum
(Monodelphis domestica)
Mammalia DPY19L3 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPY19L3 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPY19L3 34 35
  • 73.62 (n)
lizard
(Anolis carolinensis)
Reptilia DPY19L3 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpy19l3 34
  • 67.61 (n)
Str.17229 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8176 34
zebrafish
(Danio rerio)
Actinopterygii dpy19l3 34
  • 63.43 (n)
DPY19L3 35
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6659 35
  • 16 (a)
OneToMany
Species where no ortholog for DPY19L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPY19L3 Gene

ENSEMBL:
Gene Tree for DPY19L3 (if available)
TreeFam:
Gene Tree for DPY19L3 (if available)

Paralogs for DPY19L3 Gene

Paralogs for DPY19L3 Gene

(3) SIMAP similar genes for DPY19L3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DPY19L3 Gene

genes like me logo Genes that share paralogs with DPY19L3: view

Variants for DPY19L3 Gene

Sequence variations from dbSNP and Humsavar for DPY19L3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001446 -- 32,410,051(-) TGCTG(C/T)TAGAA intron-variant
rs1030094 -- 32,419,525(+) gtgca(A/G)tcaag intron-variant
rs10403559 -- 32,462,195(+) GACAT(A/T)TAAAT intron-variant
rs10403803 -- 32,445,650(+) caatg(A/T)aaaaa intron-variant
rs10405382 -- 32,405,810(+) TGTAC(C/G)CGCGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DPY19L3 Gene

Variant ID Type Subtype PubMed ID
nsv510471 OTHER sequence alteration 20534489

Variation tolerance for DPY19L3 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPY19L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPY19L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPY19L3 Gene

Disorders for DPY19L3 Gene

Relevant External Links for DPY19L3

Genetic Association Database (GAD)
DPY19L3
Human Genome Epidemiology (HuGE) Navigator
DPY19L3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPY19L3

No disorders were found for DPY19L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPY19L3 Gene

Publications for DPY19L3 Gene

  1. Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. (PMID: 26764097) Niwa Y. … Simizu S. (Mol. Biol. Cell 2016) 2 3 64
  2. Genome-wide association study of bipolar disorder in European American and African American individuals. (PMID: 19488044) Smith E.N. … Kelsoe J.R. (Mol. Psychiatry 2009) 3 46 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3 64

Products for DPY19L3 Gene

Sources for DPY19L3 Gene

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