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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPY19L2P2 Gene

pseudogene   GIFtS: 29
GCID: GC07M102815

DPY19L2 Pseudogene 2

(Previous name: dpy-19-like 2 pseudogene 2 (C. elegans))
  Search for DPY19L2P2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DPY19L2 Pseudogene 21 2
Dpy-19-Like 2 Pseudogene 2 (C. Elegans)1
EC 2.4.1.-3
Dpy-19-Like Protein 2 Pseudogene 23
Protein Dpy-19 Homolog 2-Like 23

External Ids:    HGNC: 217641   Entrez Gene: 3491522   Ensembl: ENSG000001706297   UniProtKB: Q6ZN683   
ORGUL members:         
NONCODE14:n406138 n408013 n346525      

Export aliases for DPY19L2P2 gene to outside databases

Previous GC identifers: GC07U901548 GC07M102603 GC07M097177


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DPY19L2P2 Gene: 
DPY19L2P2 (DPY19L2 pseudogene 2) is a pseudogene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68
Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPY19L2P2 gene promoter:
         Tal-1   p53   POU6F1 (c2)   Tal-1beta   E47   SRY   POU2F1   POU2F1a   c-Myb   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPY19L2P2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

DPY19L2P2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPY19L2P2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M102815:  view genomic region     (about GC identifiers)

Start:
102,815,460 bp from pter      End:
102,920,913 bp from pter
Size:
105,454 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 102,175,826-102,281,279     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DPY19L2P2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68 (See protein sequence)
Recommended Name: Putative C-mannosyltransferase DPY19L2P2  
Size: 376 amino acids; 43060 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: Could be the product of a pseudogene
Secondary accessions: Q8N9V4 Q8ND62
Alternative splicing: 3 isoforms:  Q6ZN68-1   Q6ZN68-2   Q6ZN68-3   

Explore the universe of human proteins at neXtProt for DPY19L2P2: NX_Q6ZN68

DPY19L2P2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR018732 Dpy-19

Graphical View of Domain Structure for InterPro Entry Q6ZN68

ProtoNet protein and cluster: Q6ZN68

UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68
Similarity: Belongs to the dpy-19 family


DPY19L2P2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: D19P2_HUMAN, Q6ZN68
Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
(By similarity)

     Enzyme Number (IUBMB): EC 2.4.1.-1

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPY19L2P2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DPY19L2P2 (D19P2)

Search CenterWatch for drugs/clinical trials and news about DPY19L2P2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DPY19L2P2 gene: 
NM_182634.2  

Unigene Cluster for DPY19L2P2:

Dpy-19-like 2 pseudogene 2 (C. elegans)
Hs.732579  [show with all ESTs]
Unigene Representative Sequence: NR_027768
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000439473 ENST00000438364(uc003vbg.4 uc010lit.3) ENST00000411491(uc003vbh.4)
ENST00000312132 ENST00000435536 ENST00000446373(uc003vbi.2 uc003vbj.2)

miRNA
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Additional mRNA sequence: 

AK093485.1 AK131353.1 AK302046.1 AL049437.1 AL834175.1 BC023575.2 BC045595.1 BC068601.1 
BC094802.1 BC150309.1 BX648212.1 NR_003561.2 NR_027768.1 

13 DOTS entries:

DT.91728364  DT.107770  DT.70103263  DT.100028058  DT.91728365  DT.95271516  DT.100018635  DT.121054834 
DT.121054842  DT.95271514  DT.121054840  DT.95271515  DT.92023799 

24/87 AceView cDNA sequences (see all 87):

CB105935 CB105609 BC033022 BX113171 AI697333 CB105625 BC045595 BC064909 
BU738141 AI221371 AL599936 BG461089 AL834175 AL049437 BQ427441 BX508598 
CB105892 BM453644 BC023575 CA777420 AA902910 BM711383 BU620691 BI827071 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DPY19L2P2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DPY19L2P2 Expression
About this image


Genevestigator expression for DPY19L2P2

SOURCE GeneReport for Unigene cluster: Hs.732579

UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68
Tissue specificity: Fibroblast, lung, lymphoblast, spleen and testis

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPY19L2P2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for DPY19L2P2 (if available)
TreeFam Gene Tree for DPY19L2P2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DPY19L2P2 gene
2 SIMAP similar genes for DPY19L2P2 using alignment to 1 protein entry:     D19P2_HUMAN:
DPY19L2    DPY19L1

DPY19L2P2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1889 SNPs in DPY19L2P2 are shown (see all 1889)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1380894161,2
C--102815594(+) AAAAC-/TGTTTTT 2 -- nc-transcript-variant0--------
rs24110951,2
C--102815595(+) aaactA/G/Tttttt 4 -- nc-transcript-variant0--------
rs77968531,2
C,A--102815705(+) GTTTTT/GTTTTT 2 -- nc-transcript-variant3Minor allele frequency- G:0.00NA WA 6
rs1886082151,2
--102815715(+) TTTTTC/TTTTTG 2 -- nc-transcript-variant0--------
rs29091831,2
C,F,O--102815846(-) TGCAGC/TATGCT 2 -- nc-transcript-variantese33Minor allele frequency- T:0.11WA NA EU 823
rs602510931,2
C--102815911(+) CTAGAC/GAAAAT 2 -- int10--------
rs1927428011,2
--102815982(+) TAAAGC/GGTCAT 2 -- int10--------
rs1835654521,2
--102815983(+) AAAGCA/GTCATT 2 -- int10--------
rs1871530621,2
--102816027(+) AAATAG/TAATGA 2 -- int10--------
rs1404487571,2
--102816042(+) AAGCAC/TGTTGC 2 -- int10--------

HapMap Linkage Disequilibrium report for DPY19L2P2 (102815460 - 102920913 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for DPY19L2P2:    About this table     
Variant IDTypeSubtypePubMed ID
esv2673257CNV Deletion23128226
esv2734953CNV Deletion23290073
nsv499230CNV Loss21111241
nsv831084CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DPY19L2P2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DPY19L2P2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Duplication and relocation of the functional DPY19L2 gene within low copy repeats. (PubMed id 16526957)1, 2 Carson A.R.... Scherer S.W. (2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 349152 HGNC: 21764 AceView: FLJ36166 Ensembl:ENSG00000170629 euGenes: HUgn349152
ECgene: DPY19L2P2 H-InvDB: DPY19L2P2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DPY19L2P2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DPY19L2P2 gene:
Search GeneIP for patents involving DPY19L2P2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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