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DPY19L2P2 Gene

pseudogene   GIFtS: 27
GCID: GC07M102815

DPY19L2 Pseudogene 2

(Previous name: dpy-19-like 2 pseudogene 2 (C. elegans))
  Search for DPY19L2P2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DPY19L2 Pseudogene 21 2
Dpy-19-Like 2 Pseudogene 2 (C. Elegans)1
EC 2.4.1.-3
Dpy-19-Like Protein 2 Pseudogene 23
Protein Dpy-19 Homolog 2-Like 23

External Ids:    HGNC: 217641   Entrez Gene: 3491522   Ensembl: ENSG000001706297   UniProtKB: Q6ZN683   
ORGUL members:         

Export aliases for DPY19L2P2 gene to outside databases

Previous GC identifers: GC07U901548 GC07M102603 GC07M097177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DPY19L2P2 Gene:
DPY19L2P2 (DPY19L2 pseudogene 2) is a pseudogene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68
Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DPY19L2P2 gene promoter:
         Tal-1   p53   POU6F1 (c2)   Tal-1beta   E47   SRY   POU2F1   POU2F1a   c-Myb   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPY19L2P2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

DPY19L2P2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPY19L2P2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M102815:  view genomic region     (about GC identifiers)

Start:
102,815,460 bp from pter      End:
102,920,913 bp from pter
Size:
105,454 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 102,175,826-102,281,279     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DPY19L2P2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68 (See protein sequence)
Recommended Name: Putative C-mannosyltransferase DPY19L2P2  
Size: 376 amino acids; 43060 Da
Caution: Could be the product of a pseudogene
Secondary accessions: Q8N9V4 Q8ND62
Alternative splicing: 3 isoforms:  Q6ZN68-1   Q6ZN68-2   Q6ZN68-3   

Explore the universe of human proteins at neXtProt for DPY19L2P2: NX_Q6ZN68

Explore proteomics data for DPY19L2P2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn32

  • See DPY19L2P2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018732 Dpy-19

    Graphical View of Domain Structure for InterPro Entry Q6ZN68

    ProtoNet protein and cluster: Q6ZN68

    UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68
    Similarity: Belongs to the dpy-19 family


    DPY19L2P2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: D19P2_HUMAN, Q6ZN68
    Function: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins
    (By similarity)

         Enzyme Number (IUBMB): EC 2.4.1.-1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    D19P2_HUMAN, Q6ZN68: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPY19L2P2
    Interactions:

        Search GeneGlobe Interaction Network for DPY19L2P2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for DPY19L2P2 (D19P2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DPY19L2P2 gene: 
    NM_182634.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439473 ENST00000438364(uc003vbg.4 uc010lit.3) ENST00000411491(uc003vbh.4)
    ENST00000312132 ENST00000435536 ENST00000446373(uc003vbi.2 uc003vbj.2)

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    Selected AceView cDNA sequences (see all 87):

    AL049437 BX113171 BC023575 AI221371 BC033022 BU738141 AI697333 BM453644 
    BQ427441 CB105625 CB105935 BX508598 CA777420 CB105892 BG461089 BC045595 
    AL599936 AL834175 CB105609 BC064909 AA806296 BM716588 AL043555 CB105902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPY19L2P2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DPY19L2P2 Expression
    About this image

    DPY19L2P2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPY19L2P2 Protein Expression

    UniProtKB/Swiss-Prot: D19P2_HUMAN, Q6ZN68
    Tissue specificity: Fibroblast, lung, lymphoblast, spleen and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for DPY19L2P2 (if available)
    TreeFam Gene Tree for DPY19L2P2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPY19L2P2 gene
    2 SIMAP similar genes for DPY19L2P2 using alignment to 1 protein entry:     D19P2_HUMAN:
    DPY19L2    DPY19L1

    DPY19L2P2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPY19L2P2 (see all 1889)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380894161,2
    C--102815594(+) AAAAC-/TGTTTTT 2 -- nc-transcript-variant0--------
    rs24110951,2
    C--102815595(+) aaactA/G/Tttttt 4 -- nc-transcript-variant0--------
    rs77968531,2
    C,A--102815705(+) GTTTTT/GTTTTT 2 -- nc-transcript-variant3Minor allele frequency- G:0.00NA WA 6
    rs1886082151,2
    --102815715(+) TTTTTC/TTTTTG 2 -- nc-transcript-variant0--------
    rs29091831,2
    C,F,O--102815846(-) TGCAGC/TATGCT 2 -- nc-transcript-variantese33Minor allele frequency- T:0.11WA NA EU 823
    rs602510931,2
    C--102815911(+) CTAGAC/GAAAAT 2 -- int10--------
    rs1927428011,2
    --102815982(+) TAAAGC/GGTCAT 2 -- int10--------
    rs1835654521,2
    --102815983(+) AAAGCA/GTCATT 2 -- int10--------
    rs1871530621,2
    --102816027(+) AAATAG/TAATGA 2 -- int10--------
    rs1404487571,2
    --102816042(+) AAGCAC/TGTTGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for DPY19L2P2 (102815460 - 102920913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DPY19L2P2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673257CNV Deletion23128226
    esv2734953CNV Deletion23290073
    nsv499230CNV Loss21111241
    nsv831084CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPY19L2P2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DPY19L2P2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Duplication and relocation of the functional DPY19L2 gene within low copy repeats. (PubMed id 16526957)1, 2 Carson A.R.... Scherer S.W. (BMC Genomics 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 349152 HGNC: 21764 AceView: FLJ36166 Ensembl:ENSG00000170629 euGenes: HUgn349152
    ECgene: DPY19L2P2 H-InvDB: DPY19L2P2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPY19L2P2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPY19L2P2 gene:
    Search GeneIP for patents involving DPY19L2P2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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