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Aliases for DPY19L1 Gene

Aliases for DPY19L1 Gene

  • Dpy-19-Like 1 (C. Elegans) 2 3
  • KIAA0877 4 6
  • Protein Dpy-19 Homolog 1 4
  • Dpy-19-Like Protein 1 4
  • EC 2.4.1.- 4
  • GA0500 4

External Ids for DPY19L1 Gene

Previous GeneCards Identifiers for DPY19L1 Gene

  • GC07M034742

Summaries for DPY19L1 Gene

GeneCards Summary for DPY19L1 Gene

DPY19L1 (Dpy-19-Like 1 (C. Elegans)) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is DPY19L2.

UniProtKB/Swiss-Prot for DPY19L1 Gene

  • Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPY19L1 Gene

Genomics for DPY19L1 Gene

Regulatory Elements for DPY19L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPY19L1 Gene

34,928,876 bp from pter
35,038,271 bp from pter
109,396 bases
Minus strand

Genomic View for DPY19L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPY19L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY19L1 Gene

Proteins for DPY19L1 Gene

  • Protein details for DPY19L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable C-mannosyltransferase DPY19L1
    Protein Accession:
    Secondary Accessions:
    • O94954
    • Q4G151

    Protein attributes for DPY19L1 Gene

    675 amino acids
    Molecular mass:
    77319 Da
    Quaternary structure:
    No Data Available
    • It has been suggested that DPY19L1 has a related pseudogene DPY19L1P1

    Alternative splice isoforms for DPY19L1 Gene


neXtProt entry for DPY19L1 Gene

Proteomics data for DPY19L1 Gene at MOPED

Post-translational modifications for DPY19L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPY19L1 Gene

No data available for DME Specific Peptides for DPY19L1 Gene

Domains for DPY19L1 Gene

Protein Domains for DPY19L1 Gene


Suggested Antigen Peptide Sequences for DPY19L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dpy-19 family.
  • Belongs to the dpy-19 family.
genes like me logo Genes that share domains with DPY19L1: view

No data available for Gene Families for DPY19L1 Gene

Function for DPY19L1 Gene

Molecular function for DPY19L1 Gene

UniProtKB/Swiss-Prot Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Enzyme Numbers (IUBMB) for DPY19L1 Gene

Gene Ontology (GO) - Molecular Function for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA --
GO:0016757 transferase activity, transferring glycosyl groups --
genes like me logo Genes that share ontologies with DPY19L1: view

Animal Model Products

CRISPR Products

miRNA for DPY19L1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPY19L1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DPY19L1 Gene

Localization for DPY19L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY19L1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DPY19L1 Gene COMPARTMENTS Subcellular localization image for DPY19L1 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IBA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPY19L1: view

Pathways for DPY19L1 Gene

SuperPathways for DPY19L1 Gene

No Data Available

Interacting Proteins for DPY19L1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000308695 for DPY19L1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0018406 protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan IBA --
genes like me logo Genes that share ontologies with DPY19L1: view

No data available for Pathways by source for DPY19L1 Gene

Transcripts for DPY19L1 Gene

Unigene Clusters for DPY19L1 Gene

Dpy-19-like 1 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPY19L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L1 Gene

No ASD Table

Relevant External Links for DPY19L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPY19L1 Gene

mRNA expression in normal human tissues for DPY19L1 Gene

Protein differential expression in normal tissues for DPY19L1 Gene

This gene is overexpressed in Serum (25.7) and Urine (12.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPY19L1 Gene

SOURCE GeneReport for Unigene cluster for DPY19L1 Gene Hs.408623

mRNA Expression by UniProt/SwissProt for DPY19L1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with DPY19L1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for DPY19L1 Gene

Orthologs for DPY19L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY19L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DPY19L1 35
  • 91.23 (n)
  • 94.5 (a)
DPY19L1 36
  • 85 (a)
(Canis familiaris)
Mammalia DPY19L1 35
  • 93.46 (n)
  • 97.35 (a)
DPY19L1 36
  • 97 (a)
(Mus musculus)
Mammalia Dpy19l1 35
  • 87.48 (n)
  • 92.89 (a)
Dpy19l1 16
Dpy19l1 36
  • 82 (a)
(Pan troglodytes)
Mammalia DPY19L1 35
  • 99.8 (n)
  • 99.85 (a)
DPY19L1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dpy19l1 35
  • 86.6 (n)
  • 92.74 (a)
(Monodelphis domestica)
Mammalia DPY19L1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia DPY19L1 36
  • 64 (a)
(Gallus gallus)
Aves DPY19L1 35
  • 75.9 (n)
  • 76.01 (a)
-- 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.658 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4207 35
(Danio rerio)
Actinopterygii dpy19l1l 35
  • 66.31 (n)
  • 68.47 (a)
AL935296.1 36
  • 61 (a)
dpy19l1l 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea dpy-19 35
  • 53.35 (n)
  • 44.57 (a)
dpy-19 36
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4862 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9857 36
  • 49 (a)
Species with no ortholog for DPY19L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPY19L1 Gene

Gene Tree for DPY19L1 (if available)
Gene Tree for DPY19L1 (if available)

Paralogs for DPY19L1 Gene

Paralogs for DPY19L1 Gene

(4) SIMAP similar genes for DPY19L1 Gene using alignment to 3 proteins: Pseudogenes for DPY19L1 Gene

genes like me logo Genes that share paralogs with DPY19L1: view

Variants for DPY19L1 Gene

Sequence variations from dbSNP and Humsavar for DPY19L1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7511 -- 34,929,132(+) TGATC(A/G)CTTCT utr-variant-3-prime
rs10928 -- 34,929,299(-) CCACA(G/T)CTCGC utr-variant-3-prime
rs167893 -- 35,003,121(+) cagtg(A/T)accaa intron-variant
rs170622 -- 34,992,488(+) ttttc(C/T)tgttc intron-variant
rs170649 -- 35,035,347(+) ATGGG(A/C)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPY19L1 Gene

Variant ID Type Subtype PubMed ID
dgv1127e201 CNV Deletion 23290073
nsv436907 CNV Insertion 17901297
nsv830952 CNV Gain 17160897
nsv830953 CNV Gain 17160897
dgv7249n71 CNV Loss 21882294
esv23431 CNV Loss 19812545

Relevant External Links for DPY19L1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPY19L1 Gene

Disorders for DPY19L1 Gene

Relevant External Links for DPY19L1

Genetic Association Database (GAD)

No disorders were found for DPY19L1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DPY19L1 Gene

Publications for DPY19L1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. (PMID: 22028030) Watanabe K. … Tamamaki N. (Development 2011) 2 3
  3. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for DPY19L1 Gene

Sources for DPY19L1 Gene

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