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Aliases for DPY19L1 Gene

Aliases for DPY19L1 Gene

  • Dpy-19 Like 1 2 3 5
  • Dpy-19 Like 1 (C. Elegans) 2
  • Protein Dpy-19 Homolog 1 4
  • Dpy-19-Like Protein 1 4
  • EC 2.4.1.- 4
  • KIAA0877 4
  • GA0500 4

External Ids for DPY19L1 Gene

Previous GeneCards Identifiers for DPY19L1 Gene

  • GC07M034742

Summaries for DPY19L1 Gene

GeneCards Summary for DPY19L1 Gene

DPY19L1 (Dpy-19 Like 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity. An important paralog of this gene is DPY19L2.

UniProtKB/Swiss-Prot for DPY19L1 Gene

  • Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPY19L1 Gene

Genomics for DPY19L1 Gene

Regulatory Elements for DPY19L1 Gene

Enhancers for DPY19L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F035034 1 ENCODE 14.1 +1.5 1452 3.7 ATF1 CREB3L1 ARID4B SIN3A ZNF48 ZNF2 YY1 GLIS2 ELK1 ZNF143 DPY19L1 LOC105375228
GH07F035024 0.8 ENCODE 15.1 +12.3 12331 3.0 SIX4 ZFP64 SIN3A CEBPG ZNF316 ZFHX2 GATA3 CTBP1 EED ETV6 DPY19L1 LOC105375228 MIR548N
GH07F035002 1.2 Ensembl ENCODE 7.7 +34.0 34013 3.4 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF366 ZNF416 SMARCC2 FOS SMARCC1 DPY19L1 LOC105375228 MIR548N
GH07F034906 0.5 Ensembl 14.8 +131.8 131770 0.6 GATA3 ZBTB48 ZBTB26 DPY19L1 ENSG00000251802 GC07M034905
GH07F034990 1.1 Ensembl ENCODE 6.2 +46.5 46469 2.3 SOX13 JUN MAX ZBTB40 KMT2B ZNF7 RARA CBX5 ELK1 ZNF143 DPY19L1 LOC105375228 MIR548N
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPY19L1 on UCSC Golden Path with GeneCards custom track

Promoters for DPY19L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066023 971 3000 ATF1 ARID4B SIN3A ZNF48 ZNF2 GLIS2 ELK1 ZNF143 ZNF207 REST

Genomic Location for DPY19L1 Gene

Chromosome:
7
Start:
34,928,876 bp from pter
End:
35,038,271 bp from pter
Size:
109,396 bases
Orientation:
Minus strand

Genomic View for DPY19L1 Gene

Genes around DPY19L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPY19L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPY19L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY19L1 Gene

Proteins for DPY19L1 Gene

  • Protein details for DPY19L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2PZI1-D19L1_HUMAN
    Recommended name:
    Probable C-mannosyltransferase DPY19L1
    Protein Accession:
    Q2PZI1
    Secondary Accessions:
    • O94954
    • Q4G151

    Protein attributes for DPY19L1 Gene

    Size:
    675 amino acids
    Molecular mass:
    77319 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • It has been suggested that DPY19L1 has a related pseudogene DPY19L1P1.

    Alternative splice isoforms for DPY19L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPY19L1 Gene

Post-translational modifications for DPY19L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPY19L1 Gene

No data available for DME Specific Peptides for DPY19L1 Gene

Domains & Families for DPY19L1 Gene

Protein Domains for DPY19L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPY19L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2PZI1

UniProtKB/Swiss-Prot:

D19L1_HUMAN :
  • Belongs to the dpy-19 family.
Family:
  • Belongs to the dpy-19 family.
genes like me logo Genes that share domains with DPY19L1: view

No data available for Gene Families for DPY19L1 Gene

Function for DPY19L1 Gene

Molecular function for DPY19L1 Gene

UniProtKB/Swiss-Prot Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Enzyme Numbers (IUBMB) for DPY19L1 Gene

Gene Ontology (GO) - Molecular Function for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with DPY19L1: view

Phenotypes for DPY19L1 Gene

GenomeRNAi human phenotypes for DPY19L1:
genes like me logo Genes that share phenotypes with DPY19L1: view

Animal Model Products

miRNA for DPY19L1 Gene

miRTarBase miRNAs that target DPY19L1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPY19L1 Gene

Localization for DPY19L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY19L1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPY19L1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IBA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPY19L1: view

Pathways & Interactions for DPY19L1 Gene

SuperPathways for DPY19L1 Gene

No Data Available

Interacting Proteins for DPY19L1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308695%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000308695 Q2PZI1-D19L1_HUMAN for DPY19L1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018406 protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan IBA --
genes like me logo Genes that share ontologies with DPY19L1: view

No data available for Pathways by source and SIGNOR curated interactions for DPY19L1 Gene

Transcripts for DPY19L1 Gene

Unigene Clusters for DPY19L1 Gene

Dpy-19-like 1 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L1 Gene

No ASD Table

Relevant External Links for DPY19L1 Gene

GeneLoc Exon Structure for
DPY19L1
ECgene alternative splicing isoforms for
DPY19L1

Expression for DPY19L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPY19L1 Gene

Protein differential expression in normal tissues from HIPED for DPY19L1 Gene

This gene is overexpressed in Serum (25.7) and Urine (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPY19L1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DPY19L1 Gene:

DPY19L1

SOURCE GeneReport for Unigene cluster for DPY19L1 Gene:

Hs.408623

mRNA Expression by UniProt/SwissProt for DPY19L1 Gene:

Q2PZI1-D19L1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with DPY19L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for DPY19L1 Gene

Orthologs for DPY19L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY19L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPY19L1 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia DPY19L1 34 35
  • 93.46 (n)
cow
(Bos Taurus)
Mammalia DPY19L1 34 35
  • 91.23 (n)
mouse
(Mus musculus)
Mammalia Dpy19l1 34 16 35
  • 87.48 (n)
rat
(Rattus norvegicus)
Mammalia Dpy19l1 34
  • 86.6 (n)
oppossum
(Monodelphis domestica)
Mammalia DPY19L1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPY19L1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPY19L1 34
  • 75.9 (n)
-- 35
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.658 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4207 34
zebrafish
(Danio rerio)
Actinopterygii dpy19l1l 34 35
  • 66.31 (n)
AL935296.1 35
  • 61 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-19 34 35
  • 53.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9857 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4862 34
Species where no ortholog for DPY19L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPY19L1 Gene

ENSEMBL:
Gene Tree for DPY19L1 (if available)
TreeFam:
Gene Tree for DPY19L1 (if available)

Paralogs for DPY19L1 Gene

Paralogs for DPY19L1 Gene

(4) SIMAP similar genes for DPY19L1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DPY19L1 Gene

genes like me logo Genes that share paralogs with DPY19L1: view

Variants for DPY19L1 Gene

Sequence variations from dbSNP and Humsavar for DPY19L1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10237774 -- 34,979,765(+) cctga(A/G)agaaa intron-variant
rs10242080 -- 35,005,161(+) CTATT(C/T)TTCAG intron-variant
rs10242217 -- 35,005,272(+) GTCCT(C/T)TCTGG intron-variant
rs10243141 -- 35,022,954(+) GAGAG(A/G)TTTCC intron-variant
rs10250525 -- 34,942,299(+) GGCCT(C/T)AAGCA intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPY19L1 Gene

Variant ID Type Subtype PubMed ID
nsv966775 CNV duplication 23825009
nsv951626 CNV deletion 24416366
nsv830953 CNV gain 17160897
nsv830952 CNV gain 17160897
nsv436907 CNV insertion 17901297
nsv1076887 CNV deletion 25765185
esv3612750 OTHER inversion 21293372
esv23431 CNV loss 19812545
dgv6320n100 CNV gain 25217958
dgv3525n106 CNV deletion 24896259
dgv1080e201 CNV deletion 23290073

Variation tolerance for DPY19L1 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPY19L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPY19L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPY19L1 Gene

Disorders for DPY19L1 Gene

Relevant External Links for DPY19L1

Genetic Association Database (GAD)
DPY19L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPY19L1

No disorders were found for DPY19L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPY19L1 Gene

Publications for DPY19L1 Gene

  1. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. (PMID: 22028030) Watanabe K. … Tamamaki N. (Development 2011) 2 3 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3 64

Products for DPY19L1 Gene

Sources for DPY19L1 Gene

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