Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DPT Gene

protein-coding   GIFtS: 55
GCID: GC01M168664

Dermatopontin

  See DPT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
dermatopontin1 2
Tyrosine-Rich Acidic Matrix Protein2 3
TRAMP2 3

External Ids:    HGNC: 30111   Entrez Gene: 18052   Ensembl: ENSG000001431967   OMIM: 1255975   UniProtKB: Q075073   

Export aliases for DPT gene to outside databases

Previous GC identifers: GC01M166300 GC01M164315 GC01M165360 GC01M165852 GC01M165396 GC01M166931 GC01M139910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DPT Gene:
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix
assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin
is postulated to modify the behavior of TGF-beta through interaction with decorin. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPT Gene:
DPT (dermatopontin) is a protein-coding gene. Diseases associated with DPT include aniseikonia, and anisometropia.

UniProtKB/Swiss-Prot: DERM_HUMAN, Q07507
Function: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between
the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits
cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against
low-temperature dissociation (By similarity)

Gene Wiki entry for DPT (Dermatopontin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPT gene promoter:
         NF-1   AML1a   Tal-1   FOXL1   Arnt   E47   HNF-1A   FOXJ2 (long isoform)   HNF-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPT promoter sequence
   Search Chromatin IP Primers for DPT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q12-q23   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q12-q23

DPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M168664:  view genomic region     (about GC identifiers)

Start:
168,664,695 bp from pter      End:
168,698,502 bp from pter
Size:
33,808 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DERM_HUMAN, Q07507 (See protein sequence)
Recommended Name: Dermatopontin precursor  
Size: 201 amino acids; 24005 Da
Subunit: Interacts with TGFB1, DCN and collagen (By similarity)
Secondary accessions: A8K981 Q8N4R2 Q9UIX8

Explore the universe of human proteins at neXtProt for DPT: NX_Q07507

Explore proteomics data for DPT at MOPED

Post-translational modifications: 

  • Sulfated on tyrosine residue(s) (By similarity)1
  • Modification sites at neXtProt

  • See DPT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001928.2  
    ENSEMBL proteins: 
     ENSP00000356791  

    DPT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DPT (Dermatopontin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DPT
    OriGene Protein Over-expression Lysate for DPT
    OriGene MassSpec for DPT
    OriGene Custom Protein Services for DPT
    GenScript Custom Purified and Recombinant Proteins Services for DPT
    Novus Biologicals DPT Proteins
    Novus Biologicals DPT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DPT

     
    Search eBioscience for Proteins for DPT 

    DPT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DPT (Dermatopontin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DPT
    Novus Biologicals DPT Antibodies
    Abcam antibodies for DPT
    Cloud-Clone Corp. Antibodies for DPT
    ThermoFisher Antibodies for DPT
    LSBio Antibodies in human, mouse, rat for DPT

    DPT Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DPT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DPT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DPT
    Cloud-Clone Corp. CLIAs for DPT
    Search eBioscience for ELISAs for DPT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR026645 Dermatopontin_fam

    Graphical View of Domain Structure for InterPro Entry Q07507

    ProtoNet protein and cluster: Q07507

    UniProtKB/Swiss-Prot: DERM_HUMAN, Q07507
    Similarity: Belongs to the dermatopontin family


    Find genes that share domains with DPT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DERM_HUMAN, Q07507
    Function: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between
    the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits
    cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against
    low-temperature dissociation (By similarity)
    Induction: Induced by TGFB1, repressed by IL4/interleukin-4

         Genatlas biochemistry entry for DPT:
    dermatopontin,human proteoglycan binding cell adhesion protein,22kDa

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dpt):
     adipose tissue  growth/size/body  integument  vision/eye 

    Find genes that share phenotypes with DPT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dpttm1Hsh for DPT

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DPT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPT

    miRNA
    Products:
        
    miRTarBase miRNAs that target DPT:
    hsa-mir-148b-3p (MIRT019412)

    Block miRNA regulation of human, mouse, rat DPT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DPT
    SwitchGear 3'UTR luciferase reporter plasmidDPT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DPT
    Predesigned siRNA for gene silencing in human, mouse, rat DPT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DPT

    Clone
    Products:
         
    OriGene clones in human, mouse for DPT (see all 7)
    OriGene ORF clones in mouse, rat for DPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DPT (NM_001937)
    Sino Biological Human cDNA Clone for DPT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DPT
    Browse ESI BIO Cell Lines and PureStem Progenitors for DPT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DERM_HUMAN, Q07507: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0031012colocalizes with extracellular matrix ISS--

    Find genes that share ontologies with DPT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DPT About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway


    1 Sino Biological Pathway for DPT
        TGF-beta Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPT
    Interactions:

        GeneGlobe Interaction Network for DPT

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for DPT (Q075072, 3 ENSP000003567914) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-64058 I2D: score=5 
    ENSG00000096155P463792, 3MINT-64058 I2D: score=5 
    ENSG00000227761P463792, 3MINT-64058 I2D: score=5 
    ENSG00000228760P463792, 3MINT-64058 I2D: score=5 
    ENSG00000229524P463792, 3MINT-64058 I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0030199collagen fibril organization IEA--

    Find genes that share ontologies with DPT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPT (DERM)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DPT gene: 
    NM_001937.4  

    Unigene Cluster for DPT:

    Dermatopontin
    Hs.80552  [show with all ESTs]
    Unigene Representative Sequence: NM_001937
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367817(uc001gfp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DPT using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DPT
    SwitchGear 3'UTR luciferase reporter plasmidDPT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DPT
    Predesigned siRNA for gene silencing in human, mouse, rat DPT
    Clone
    Products:
         
    OriGene clones in human, mouse for DPT (see all 7)
    OriGene ORF clones in mouse, rat for DPT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DPT (NM_001937)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DPT
    OriGene qSTAR qPCR primer pairs in human, mouse for DPT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPT
      QuantiTect SYBR Green Assays in human, mouse, rat DPT
      QuantiFast Probe-based Assays in human, mouse, rat DPT

    Additional mRNA sequence: 

    AF086330.1 AL049455.1 BC033736.1 

    4 DOTS entries:

    DT.446347  DT.121339269  DT.95219687  DT.86846979 

    Selected AceView cDNA sequences (see all 201):

    CA447095 BP341714 W73194 CD690542 CR614953 CR596260 W02773 CD245457 
    BI768348 AI870036 AI146848 AL553890 C02335 AW016451 AI620191 AI140053 
    AW015361 CA405771 AI686000 BM729207 AI621291 BQ019103 AL543317 CR591165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DPT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAGCAATC
    DPT Expression
    About this image


    DPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 13 entries
             Osteochondro Mesenchymal Cells Vertebrae
             Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 13 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
             Intervertebral Disc
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
    DPT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80552

    UniProtKB/Swiss-Prot: DERM_HUMAN, Q07507
    Tissue specificity: Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an
    intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in
    fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in
    normal skin fibroblasts

        Custom PCR Arrays for DPT
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DPT
    OriGene qSTAR qPCR primer pairs in human, mouse for DPT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPT
    QuantiTect SYBR Green Assays in human, mouse, rat DPT
    QuantiFast Probe-based Assays in human, mouse, rat DPT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DPT gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpt1 , 5 dermatopontin1, 5 88.06(n)1
    92.04(a)1
      1 (72.12 cM)5
    564291  NM_019759.21  NP_062733.11 
     1647967325 
    chicken
    (Gallus gallus)
    Aves DPT1 dermatopontin 77.89(n)
    82.32(a)
      768904  XM_001231675.3  XP_001231676.2 
    lizard
    (Anolis carolinensis)
    Reptilia DPT6
    dermatopontin
    81(a)
    1 ↔ 1
    3(175336625-175355099)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dpt1 dermatopontin 73.01(n)
    78.8(a)
      594987  NM_001030428.1  NP_001025599.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-98p3.21 si:dkey-98p3.2 66.47(n)
    64.16(a)
      555282  NM_001030085.2  NP_001025256.2 


    ENSEMBL Gene Tree for DPT (if available)
    TreeFam Gene Tree for DPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DPT (see all 881)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674398711,2
    C--139931888(-) GAACT-/TAAAG 
            
    TAAAA
    1 -- int12Minor allele frequency- TAAAG:0.25NA 4
    rs1464208041,2
    --168664206(+) ATACCA/CTCACC 1 -- int10--------
    rs1895156291,2
    --168664219(+) TGGCTA/GAGAGT 1 -- int10--------
    rs1397920371,2
    --168664246(+) TAGAGA/GGGGTG 1 -- int10--------
    rs6814451,2
    C,F,O,A,H--168664259(+) TGGCAG/AGGTAC 1 -- int119Minor allele frequency- A:0.34NA EA NS WA CSA 970
    rs799145351,2
    C--168664265(+) GGTACG/ACGATC 1 -- int13Minor allele frequency- A:0.05NA EA 242
    rs1811257041,2
    --168664267(+) TACGCA/GATCCC 1 -- int10--------
    rs667015641,2
    C--168664345(+) AAAAA-/AGGCAA 1 -- int10--------
    rs1432728851,2
    C--168664392(+) GGGACA/TTCCTG 1 -- int10--------
    rs6823671,2
    C,F,O,A,H--168664450(+) GCTGAG/AAAAAG 1 -- int129Minor allele frequency- A:0.45NA EA NS WA CSA 2737

    HapMap Linkage Disequilibrium report for DPT (168664695 - 168698502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DPT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831847CNV Gain17160897
    nsv831836CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPT
    DNA2.0 Custom Variant and Variant Library Synthesis for DPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 125597    OMIM disorders: --

    4 diseases for DPT:    
    About MalaCards
    aniseikonia    anisometropia    cycloplegia    amblyopia

    16 diseases from the University of Copenhagen DISEASES database for DPT:
    Pertussis     Diphtheria     Measles     Tetanus
    Poliomyelitis     Astigmatism     Anisometropia     Myopia
    Cycloplegia     Hyperopia     Mumps     Aniseikonia
    Rubella     Amblyopia     Japanese encephalitis     Hepatitis B

    Find genes that share disorders with DPT           About GenesLikeMe

    4 Novoseek inferred disease relationships for DPT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leiomyoma 44.4 5 15139000 (4)
    infarct 11.4 3 12395208 (2), 16987749 (1)
    myocardial infarction 3.52 1 16987749 (1)
    tumors 0 2 16899568 (1)

    Genetic Association Database (GAD): DPT
    Human Genome Epidemiology (HuGE) Navigator: DPT (6 documents)

    Export disorders for DPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DPT gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with DPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin). (PubMed id 8104875)1, 2, 3, 9 Superti-Furga A.... Gitzelmann R. (Genomics 1993)
    2. Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. (PubMed id 10233760)1, 2, 9 Kuroda K.... Shinkai H. (J. Invest. Dermatol. 1999)
    3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    4. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    5. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)1, 4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Dermatopontin interacts with transforming growth factor beta and enhances its biological activity. (PubMed id 9895299)1, 9 Okamoto O.... Sato Y. (Biochem. J. 1999)
    9. Dermatopontin is expressed in human liver and is downregulated in hepatocellular carcinoma. (PubMed id 19916908)1, 9 Li X....Zhang C. (Biochemistry Mosc. 2009)
    10. Tyrosine-rich acidic matrix protein (TRAMP) is a tyrosine-sulphated and widely distributed protein of the extracellular matrix. (PubMed id 8082810)1, 9 Forbes E.G....Hulmes D.J. (FEBS Lett. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1805 HGNC: 3011 AceView: DPT Ensembl:ENSG00000143196 euGenes: HUgn1805
    ECgene: DPT H-InvDB: DPT

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DPT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DPT gene:
    Search GeneIP for patents involving DPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for DPT (Dermatopontin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for DPT (Dermatopontin)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DPT  
     OriGene qPCR primer pairs and template standards for DPT   OriGene Protein Over-expression Lysate for DPT  
     OriGene MassSpec something-or-other for DPT   OriGene clones in human, mouse for DPT  
     OriGene qSTAR qPCR primer pairs in human, mouse for DPT   OriGene Purified Protein for DPT  
     OriGene ORF clones in mouse, rat for DPT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DPT   OriGene Custom Protein Services for DPT  

     
     
     Block miRNA regulation of human, mouse, rat DPT using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DPT
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPT Predesigned siRNA for gene silencing in human, mouse, rat DPT
     QuantiFast Probe-based Assays in human, mouse, rat DPT QuantiTect SYBR Green Assays in human, mouse, rat DPT
     Custom PCR Arrays for DPT Search Chromatin IP Primers for DPT
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPT  GeneGlobe Interaction Network for DPT
     Regulatory tfbs in DPT promoter
     GenScript Custom Purified and Recombinant Proteins Services for DPT GenScript cDNA clones with any tag delivered in your preferred vector for DPT
     GenScript Custom Assay Services for DPT GenScript Custom overexpressing Cell Line Services for DPT
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DPT (DERM)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DPT
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DPT antibodies
     DPT proteins
     DPT lysates
     Antibodies for DPT
     See all of Abcam's Antibodies, Kits and Proteins for DPT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DPT
     Antibodies for DPT
     ELISAs for DPT
     CLIAs for DPT



     Browse ESI BIO Cell Lines and PureStem Progenitors for DPT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPT
     SwitchGear 3'UTR luciferase reporter plasmids for DPT
     SwitchGear Promoter luciferase reporter plasmids for DPT
     ThermoFisher Antibodies for DPT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPT
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPT
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DPT
     LSBio Antibodies in human, mouse, rat for DPT
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DPT
      Search eBioscience for proteins for DPT
      Search eBioscience for elisas for DPT
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DPT gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4