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Aliases for DPRX Gene

Aliases for DPRX Gene

  • Divergent-Paired Related Homeobox 2 3

External Ids for DPRX Gene

Summaries for DPRX Gene

Entrez Gene Summary for DPRX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPRX Gene

DPRX (Divergent-Paired Related Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for DPRX Gene

  • Putative transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPRX Gene

Genomics for DPRX Gene

Genomic Location for DPRX Gene

Start:
53,632,056 bp from pter
End:
53,637,009 bp from pter
Size:
4,954 bases
Orientation:
Plus strand

Genomic View for DPRX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPRX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPRX Gene

Regulatory Elements for DPRX Gene

Transcription factor binding sites by QIAGEN in the DPRX gene promoter:

Proteins for DPRX Gene

  • Protein details for DPRX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFQ7-DPRX_HUMAN
    Recommended name:
    Divergent paired-related homeobox
    Protein Accession:
    A6NFQ7
    Secondary Accessions:

    Protein attributes for DPRX Gene

    Size:
    191 amino acids
    Molecular mass:
    21648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPRX Gene

Proteomics data for DPRX Gene at MOPED

Post-translational modifications for DPRX Gene

No Post-translational modifications

Other Protein References for DPRX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPRX Gene

Domains for DPRX Gene

Gene Families for DPRX Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Protein Domains for DPRX Gene

UniProtKB/Swiss-Prot:

DPRX_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • A6NFQ7
Family:
  • Belongs to the paired homeobox family.:
    • A6NFQ7
genes like me logo Genes that share domains with DPRX: view

Function for DPRX Gene

Molecular function for DPRX Gene

UniProtKB/Swiss-Prot Function: Putative transcription factor.

Gene Ontology (GO) - Molecular Function for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DPRX Gene

Localization for DPRX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPRX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPRX Gene COMPARTMENTS Subcellular localization image for DPRX gene
Compartment Confidence
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DPRX: view

Pathways for DPRX Gene

SuperPathways for DPRX Gene

No Data Available

Interacting Proteins for DPRX Gene

Gene Ontology (GO) - Biological Process for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for Pathways by source for DPRX Gene

Transcripts for DPRX Gene

mRNA/cDNA for DPRX Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DPRX Gene

No ASD Table

Relevant External Links for DPRX Gene

GeneLoc Exon Structure for
DPRX
ECgene alternative splicing isoforms for
DPRX

Expression for DPRX Gene

mRNA expression in normal human tissues for DPRX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPRX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (5.8), Muscle - Skeletal (5.4), Testis (4.4), and Heart - Left Ventricle (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DPRX Gene

SOURCE GeneReport for Unigene cluster for DPRX Gene Hs.579941

genes like me logo Genes that share expressions with DPRX: view

Orthologs for DPRX Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPRX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPRX 36
  • 98.95 (n)
  • 97.38 (a)
DPRX 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 59 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
DPRX 36
  • 71.57 (n)
  • 60 (a)
mouse
(Mus musculus)
Mammalia Crxos1 16
Species with no ortholog for DPRX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPRX Gene

ENSEMBL:
Gene Tree for DPRX (if available)
TreeFam:
Gene Tree for DPRX (if available)

Paralogs for DPRX Gene

Selected SIMAP similar genes for DPRX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPRX: view

No data available for Paralogs for DPRX Gene

Variants for DPRX Gene

Sequence variations from dbSNP and Humsavar for DPRX Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4801995 -- 53,631,725(+) ATTGC(A/G)CTCCA upstream-variant-2KB
rs7256933 -- 53,635,290(+) taggc(A/G)taagc intron-variant
rs8102163 -- 53,633,029(+) ggtgg(C/T)tcatg intron-variant
rs8103231 -- 53,633,160(+) gcatg(G/T)cagtg intron-variant
rs10401357 -- 53,635,905(+) CTCTC(C/T)TATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPRX Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
nsv515586 CNV Loss 19592680

Relevant External Links for DPRX Gene

HapMap Linkage Disequilibrium report
DPRX

Disorders for DPRX Gene

No disorders were found for DPRX Gene.

No data available for UniProtKB/Swiss-Prot for DPRX Gene

Publications for DPRX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for DPRX Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate DPRX
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DPRX
    • Block miRNA regulation of DPRX using miScript Target Protectors

    Sources for DPRX Gene

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