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GIFtS

DPRX Gene

protein-coding   GIFtS: 35
GCID: GC19P054136

divergent-paired related homeobox
  Search for DPRX
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DPRX    

Aliases
for DPRX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Divergent-Paired Related Homeobox1 2
Divergent Paired-Related Homeobox2

External Ids:    HGNC: 321661   Entrez Gene: 5038342   Ensembl: ENSG000002045957   OMIM: 6111655   UniProtKB: A6NFQ73   

Export aliases for DPRX gene to outside databases

Previous GC identifers: GC19U900486 GC19P058828


Summaries
for DPRX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DPRX:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development.
Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a
member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple,
related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or
embryonic cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DPRX_HUMAN, A6NFQ7
Function: Putative transcription factor (By similarity)




Genomic Views
for DPRX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPRX gene promoter:
         E4BP4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DPRX promoter sequence
   Search SABiosciences Chromatin IP Primers for DPRX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPRX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

DPRX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPRX gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054136:  view genomic region     (about GC identifiers)

Start:
 54,135,310 bp from pter      End:
 54,140,263 bp from pter
Size:
 4,954 bases      Orientation:
 plus strand

Proteins
for DPRX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPRX_HUMAN, A6NFQ7 (See protein sequence)
Recommended Name: Divergent paired-related homeobox  
Size: 191 amino acids; 21648 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for DPRX: NX_A6NFQ7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NFQ7

    • DPRX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001012746.1  
    ENSEMBL proteins: 
     ENSP00000365838  

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    Uscn Proteins for DPRX

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    DPRX for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DPRX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DPRX for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry A6NFQ7

    ProtoNet protein and cluster: A6NFQ7

    UniProtKB/Swiss-Prot: DPRX_HUMAN, A6NFQ7
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for DPRX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPRX_HUMAN, A6NFQ7
    Function: Putative transcription factor (By similarity)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    DPRX for ontologies           About GeneDecksing



    Pathways & Interactions
    for DPRX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPRX

    1 Interacting protein for DPRX (A6NFQ73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG5Q9H1Y03I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--


    DPRX for ontologies           About GeneDecksing



    Drugs & Compounds
    for DPRX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPRX
    Search CenterWatch for drugs/clinical trials and news about DPRX 

    Transcripts
    for DPRX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for DPRX gene: 
    NM_001012728.1  

    Unigene Cluster for DPRX:

    Divergent-paired related homeobox
    Hs.579941
    Unigene Representative Sequence: NM_001012728
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376650(uc002qcf.1)

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    Inhib. RNA
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    Clone
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    NM_001012728 (human cat#: RC220805)  NM_001033638 (mouse cat#: MR224386)  
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    Primer
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    GeneLoc Exon Structure


    Expression
    for DPRX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPRX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCACTAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DPRX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DPRX Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.579941
        SABiosciences Custom PCR Arrays for DPRX
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for DPRX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for DPRX gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Crxos15 Crx opposite strand transcript 1   --   7 (8.60 cM) 15882617 


    ENSEMBL Gene Tree for DPRX (if available)
    TreeFam Gene Tree for DPRX (if available) 

    Paralogs
    for DPRX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPRX gene
    2 SIMAP similar genes for DPRX using alignment to 1 protein entry:     DPRX_HUMAN:
    POU6F1    HOXB1

    DPRX for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for DPRX (see all 7)
    PGOHUM00000248130 PGOHUM00000237352 PGOHUM00000239172 PGOHUM00000240455 PGOHUM00000243162


    Genomic Variants
    for DPRX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/150 NCBI SNPs in DPRX are shown (see all 150)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1413824791,2
    		--54133445(+) CTGGGC/TGACAG 1 -- us2k10--------
    rs1503780661,2
    		--54133446(+) TGGGCG/TACAGA 1 -- us2k10--------
    rs288206441,2
    		--54133457(+) GTGAGA/GCTCCA 1 -- us2k10--------
    rs2007931321,2
    		--54133472(+) AAAAA-/CAAAAA 1 -- us2k10--------
    rs121509621,2
    		C,--54133473(+) AAAAAC/AAAAAA 1 -- us2k1 trp31Minor allele frequency- A:0.50NA 2
    rs287182411,2
    		--54133486(+) AAACTC/TTCATG 1 -- us2k10--------
    rs605525411,2
    		F,--54133519(+) TGTGAA/TTTGCC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1997293151,2
    		C--54133997(+) AATGGA/CAAGAA 1 -- us2k10--------
    rs1465063681,2
    		C,--54134005(+) AAAAA-/CCTGCC 1 -- us2k10--------
    rs1998808531,2
    		C--54134005(-) GGCAGG/TTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPRX (54135310 - 54140263 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DPRX: --

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    Disorders / Diseases
    for DPRX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DPRX for disorders           About MalaCards

    DPRX for disorders           About GeneDecksing

    OMIM gene information: 611165    OMIM disorders: --


    Export disorders for DPRX gene to outside databases

    Publications
    for DPRX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPRX gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DPRX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PubMed id 17005330)1, 2 Booth H.A. and Holland P.W.H. (2007)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    External Searches for DPRX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DPRX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 503834 HGNC: 32166 Ensembl:ENSG00000204595 euGenes: HUgn503834 ECgene: DPRX
    H-InvDB: DPRX

    Other Databases showing DPRX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DPRX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPRX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DPRX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DPRX gene:
    Search GeneIP for patents involving DPRX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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