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Aliases for DPRX Gene

Aliases for DPRX Gene

  • Divergent-Paired Related Homeobox 2 3 5

External Ids for DPRX Gene

Previous GeneCards Identifiers for DPRX Gene

  • GC19U900486
  • GC19P058828
  • GC19P054136
  • GC19P053632

Summaries for DPRX Gene

Entrez Gene Summary for DPRX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPRX Gene

DPRX (Divergent-Paired Related Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for DPRX Gene

  • Putative transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPRX Gene

Genomics for DPRX Gene

Regulatory Elements for DPRX Gene

Transcription factor binding sites by QIAGEN in the DPRX gene promoter:

Genomic Location for DPRX Gene

Chromosome:
19
Start:
53,601,119 bp from pter
End:
53,637,038 bp from pter
Size:
35,920 bases
Orientation:
Plus strand

Genomic View for DPRX Gene

Genes around DPRX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPRX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPRX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPRX Gene

Proteins for DPRX Gene

  • Protein details for DPRX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFQ7-DPRX_HUMAN
    Recommended name:
    Divergent paired-related homeobox
    Protein Accession:
    A6NFQ7

    Protein attributes for DPRX Gene

    Size:
    191 amino acids
    Molecular mass:
    21648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPRX Gene

Proteomics data for DPRX Gene at MOPED

Post-translational modifications for DPRX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPRX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPRX Gene

Domains & Families for DPRX Gene

Gene Families for DPRX Gene

Protein Domains for DPRX Gene

Suggested Antigen Peptide Sequences for DPRX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFQ7

UniProtKB/Swiss-Prot:

DPRX_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DPRX: view

Function for DPRX Gene

Molecular function for DPRX Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.
genes like me logo Genes that share phenotypes with DPRX: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPRX Gene

Localization for DPRX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPRX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPRX Gene COMPARTMENTS Subcellular localization image for DPRX gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DPRX Gene

Pathways & Interactions for DPRX Gene

SuperPathways for DPRX Gene

No Data Available

Interacting Proteins for DPRX Gene

Gene Ontology (GO) - Biological Process for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for Pathways by source and SIGNOR curated interactions for DPRX Gene

Drugs & Compounds for DPRX Gene

No Compound Related Data Available

Transcripts for DPRX Gene

mRNA/cDNA for DPRX Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DPRX Gene

No ASD Table

Relevant External Links for DPRX Gene

GeneLoc Exon Structure for
DPRX
ECgene alternative splicing isoforms for
DPRX

Expression for DPRX Gene

mRNA expression in normal human tissues for DPRX Gene

mRNA differential expression in normal tissues according to GTEx for DPRX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.8), Muscle - Skeletal (x5.4), Testis (x4.4), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for DPRX Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPRX Gene



SOURCE GeneReport for Unigene cluster for DPRX Gene Hs.579941

genes like me logo Genes that share expression patterns with DPRX: view

Protein tissue co-expression partners for DPRX Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DPRX Gene

Orthologs for DPRX Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPRX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPRX 35
  • 98.95 (n)
  • 97.38 (a)
DPRX 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
DPRX 35
  • 71.57 (n)
  • 60 (a)
Species with no ortholog for DPRX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPRX Gene

ENSEMBL:
Gene Tree for DPRX (if available)
TreeFam:
Gene Tree for DPRX (if available)

Paralogs for DPRX Gene

(2) SIMAP similar genes for DPRX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPRX: view

No data available for Paralogs for DPRX Gene

Variants for DPRX Gene

Sequence variations from dbSNP and Humsavar for DPRX Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs892127 -- 53,621,569(-) ATCAG(C/T)CTGCC intron-variant
rs870845 -- 53,621,384(-) AGGCA(C/T)GGGTG intron-variant
rs2865836 -- 53,609,326(+) agctg(C/G)gcatg intron-variant
rs2865837 -- 53,609,608(+) ctcct(A/G)taatc intron-variant
rs4368264 -- 53,608,800(+) acaca(A/G)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPRX Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
nsv515586 CNV Loss 19592680

Variation tolerance for DPRX Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPRX Gene

HapMap Linkage Disequilibrium report
DPRX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPRX Gene

Disorders for DPRX Gene

Relevant External Links for DPRX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPRX

No disorders were found for DPRX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPRX Gene

Publications for DPRX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3 4 67

Products for DPRX Gene

Sources for DPRX Gene

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