Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DPRX Gene

Aliases for DPRX Gene

  • Divergent-Paired Related Homeobox 2 3 5

External Ids for DPRX Gene

Previous GeneCards Identifiers for DPRX Gene

  • GC19U900486
  • GC19P058828
  • GC19P054136
  • GC19P053632

Summaries for DPRX Gene

Entrez Gene Summary for DPRX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPRX Gene

DPRX (Divergent-Paired Related Homeobox) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. GO annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for DPRX Gene

  • Putative transcription factor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPRX Gene

Genomics for DPRX Gene

Regulatory Elements for DPRX Gene

Enhancers for DPRX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053656 1.3 ENCODE dbSUPER 11.8 +57.1 57082 2.4 HDGF FOXA2 PKNOX1 ATF1 MLX CREB3L1 ARID4B SIN3A ZNF2 YY1 RN7SL317P DPRX LOC100288093 RNU6-698P
GH19G053840 1.3 Ensembl ENCODE 10.5 +241.0 241010 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 GATA2 ZNF143 FOS SP3 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19G053511 1.2 Ensembl ENCODE 10.4 -89.1 -89119 0.4 PKNOX1 ARID4B KLF17 INSM2 FEZF1 ZNF2 RAD21 GLIS2 ZNF366 ZNF143 DPRX RN7SL317P RNU6-698P ENSG00000274892 ZNF331
GH19G053660 1 ENCODE dbSUPER 11.8 +58.4 58383 0.2 HDAC1 CTCF ATF1 SAP30 MAX SIN3A RBBP5 RAD21 GATA3 POLR2A MIR520A RN7SL317P DPRX MIR526B MIR525 MIR519B MIR520B MIR518F MIR518B MIR520C
GH19G053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +244.0 243975 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR519E MIR515-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPRX on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DPRX gene promoter:

Genomic Location for DPRX Gene

Chromosome:
19
Start:
53,601,119 bp from pter
End:
53,637,038 bp from pter
Size:
35,920 bases
Orientation:
Plus strand

Genomic View for DPRX Gene

Genes around DPRX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPRX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPRX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPRX Gene

Proteins for DPRX Gene

  • Protein details for DPRX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFQ7-DPRX_HUMAN
    Recommended name:
    Divergent paired-related homeobox
    Protein Accession:
    A6NFQ7

    Protein attributes for DPRX Gene

    Size:
    191 amino acids
    Molecular mass:
    21648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPRX Gene

Post-translational modifications for DPRX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPRX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPRX Gene

Domains & Families for DPRX Gene

Gene Families for DPRX Gene

Protein Domains for DPRX Gene

Suggested Antigen Peptide Sequences for DPRX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFQ7

UniProtKB/Swiss-Prot:

DPRX_HUMAN :
  • Belongs to the paired homeobox family.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DPRX: view

Function for DPRX Gene

Molecular function for DPRX Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Gene Ontology (GO) - Molecular Function for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DPRX: view
genes like me logo Genes that share phenotypes with DPRX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPRX Gene

Localization for DPRX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPRX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPRX gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DPRX: view

Pathways & Interactions for DPRX Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with DPRX: view

Pathways by source for DPRX Gene

1 BioSystems pathway for DPRX Gene

Interacting Proteins for DPRX Gene

Gene Ontology (GO) - Biological Process for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for SIGNOR curated interactions for DPRX Gene

Drugs & Compounds for DPRX Gene

No Compound Related Data Available

Transcripts for DPRX Gene

mRNA/cDNA for DPRX Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPRX Gene

No ASD Table

Relevant External Links for DPRX Gene

GeneLoc Exon Structure for
DPRX
ECgene alternative splicing isoforms for
DPRX

Expression for DPRX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPRX Gene

mRNA differential expression in normal tissues according to GTEx for DPRX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.8), Muscle - Skeletal (x5.4), Testis (x4.4), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for DPRX Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPRX Gene



Protein tissue co-expression partners for DPRX Gene

NURSA nuclear receptor signaling pathways regulating expression of DPRX Gene:

DPRX

SOURCE GeneReport for Unigene cluster for DPRX Gene:

Hs.579941
genes like me logo Genes that share expression patterns with DPRX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPRX Gene

Orthologs for DPRX Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPRX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPRX 34 35
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia DPRX 34
  • 71.57 (n)
-- 35
  • 59 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
Species where no ortholog for DPRX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPRX Gene

ENSEMBL:
Gene Tree for DPRX (if available)
TreeFam:
Gene Tree for DPRX (if available)

Paralogs for DPRX Gene

(2) SIMAP similar genes for DPRX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPRX: view

No data available for Paralogs for DPRX Gene

Variants for DPRX Gene

Sequence variations from dbSNP and Humsavar for DPRX Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000060939 -- 53,616,719(+) ATTGC(A/C)TTCCA intron-variant
rs1000074107 -- 53,616,910(+) TGCTC(-/TGG)TGGTG intron-variant
rs1000083046 -- 53,623,492(+) AATTA(C/G)CCTGG intron-variant
rs1000118340 -- 53,606,956(+) CAATG(A/C)CATCA intron-variant, upstream-variant-2KB
rs1000125779 -- 53,611,799(+) GGTGA(A/C)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPRX Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv1055718 CNV gain 25217958
nsv515586 CNV loss 19592680
nsv580107 CNV gain 21841781

Variation tolerance for DPRX Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPRX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPRX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPRX Gene

Disorders for DPRX Gene

Relevant External Links for DPRX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPRX

No disorders were found for DPRX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPRX Gene

Publications for DPRX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for DPRX Gene

Sources for DPRX Gene

Content
Loading form....