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Aliases for DPPA5 Gene

Aliases for DPPA5 Gene

  • Developmental Pluripotency Associated 5 2 3 5
  • ESG1 3 4
  • Developmental Pluripotency-Associated 5 Protein 3
  • Embryonal Stem Cell-Specific Gene 1 Protein 4
  • Embryonal Stem Cell Specific Gene 1 3
  • HDPPA5 4
  • ESG-1 4

External Ids for DPPA5 Gene

Previous GeneCards Identifiers for DPPA5 Gene

  • GC00U909478
  • GC06U900763
  • GC06M074120
  • GC06M074062
  • GC06M071261

Summaries for DPPA5 Gene

Entrez Gene Summary for DPPA5 Gene

  • This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]

GeneCards Summary for DPPA5 Gene

DPPA5 (Developmental Pluripotency Associated 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for DPPA5 Gene

  • Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).

Additional gene information for DPPA5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA5 Gene

Genomics for DPPA5 Gene

GeneHancer (GH) Regulatory Elements for DPPA5 Gene

Promoters and enhancers for DPPA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I073354 Promoter 0.5 EPDnew 550.8 0.0 -3 0.1 DPPA5 KHDC3L
GH06I073262 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10 +90.6 90561 3.4 PKNOX1 RB1 SIN3A ZBTB40 ZNF335 ZNF121 GLIS2 ETV6 SMARCA5 CBFB ENSG00000229852 ENSG00000243501 KHDC1 EIF3EP1 MTO1 DPPA5 KHDC3L RPSAP41
GH06I073388 Enhancer 1.2 Ensembl ENCODE 11.4 -34.7 -34714 1.3 ATF1 ARNT ZNF2 POLR2B ZNF766 GLIS2 ZNF143 KLF7 ATF7 GTF2B EEF1A1 KHDC3L DPPA5 RPS6P8 OOEP RPL39P3
GH06I073326 Enhancer 0.6 ENCODE 11.1 +27.5 27502 0.2 CTCF ZNF654 ARNT TRIM22 REST RAD21 MAFF SKIL KLF16 ZNF143 PAICSP3 DPPA5 KHDC3L SDCBP2P1
GH06I073234 Enhancer 0.6 ENCODE 10.7 +118.6 118621 2.4 ZNF146 JUN MAX CEBPB EP300 ZBTB40 SP1 JUND MAFF STAT3 GC06P073237 ENSG00000229852 ENSG00000243501 KHDC1 KHDC3L DPPA5 KHDC1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPPA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPPA5 gene promoter:

Genomic Locations for DPPA5 Gene

Genomic Locations for DPPA5 Gene
chr6:73,353,062-73,354,295
(GRCh38/hg38)
Size:
1,234 bases
Orientation:
Minus strand
chr6:74,062,785-74,064,018
(GRCh37/hg19)

Genomic View for DPPA5 Gene

Genes around DPPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA5 Gene

Proteins for DPPA5 Gene

  • Protein details for DPPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NC42-DPPA5_HUMAN
    Recommended name:
    Developmental pluripotency-associated 5 protein
    Protein Accession:
    A6NC42
    Secondary Accessions:
    • B2RPQ7

    Protein attributes for DPPA5 Gene

    Size:
    116 amino acids
    Molecular mass:
    13498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPPA5 Gene

Post-translational modifications for DPPA5 Gene

No Post-translational modifications

Other Protein References for DPPA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPPA5 Gene

Domains & Families for DPPA5 Gene

Gene Families for DPPA5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DPPA5 Gene

Suggested Antigen Peptide Sequences for DPPA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NC42

UniProtKB/Swiss-Prot:

DPPA5_HUMAN :
  • Belongs to the KHDC1 family.
Family:
  • Belongs to the KHDC1 family.
genes like me logo Genes that share domains with DPPA5: view

Function for DPPA5 Gene

Molecular function for DPPA5 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in differentiated embryonic stem (ESC) cells, compared with strong expression in undifferentiated ESC cells.

Phenotypes From GWAS Catalog for DPPA5 Gene

Gene Ontology (GO) - Molecular Function for DPPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with DPPA5: view

Phenotypes for DPPA5 Gene

genes like me logo Genes that share phenotypes with DPPA5: view

Animal Models for DPPA5 Gene

MGI Knock Outs for DPPA5:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPPA5 Gene

Localization for DPPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPPA5 gene
Compartment Confidence
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DPPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DPPA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPPA5 Gene

Pathways & Interactions for DPPA5 Gene

SuperPathways for DPPA5 Gene

No Data Available

Interacting Proteins for DPPA5 Gene

Gene Ontology (GO) - Biological Process for DPPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with DPPA5: view

No data available for Pathways by source and SIGNOR curated interactions for DPPA5 Gene

Drugs & Compounds for DPPA5 Gene

No Compound Related Data Available

Transcripts for DPPA5 Gene

mRNA/cDNA for DPPA5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DPPA5 Gene

Developmental pluripotency associated 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA5 Gene

No ASD Table

Relevant External Links for DPPA5 Gene

GeneLoc Exon Structure for
DPPA5
ECgene alternative splicing isoforms for
DPPA5

Expression for DPPA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPPA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPPA5 Gene

This gene is overexpressed in Testis (x32.1) and Ovary (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of DPPA5 Gene:

DPPA5

SOURCE GeneReport for Unigene cluster for DPPA5 Gene:

Hs.125331
genes like me logo Genes that share expression patterns with DPPA5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPPA5 Gene

Orthologs for DPPA5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPPA5 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia DPPA5 33 34
  • 84.2 (n)
mouse
(Mus musculus)
Mammalia Dppa5a 33 16 34
  • 77.38 (n)
Gm10112 34
  • 64 (a)
OneToMany
Gm5250 34
  • 61 (a)
OneToMany
Species where no ortholog for DPPA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA5 Gene

ENSEMBL:
Gene Tree for DPPA5 (if available)
TreeFam:
Gene Tree for DPPA5 (if available)

Paralogs for DPPA5 Gene

(2) SIMAP similar genes for DPPA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPPA5: view

No data available for Paralogs for DPPA5 Gene

Variants for DPPA5 Gene

Sequence variations from dbSNP and Humsavar for DPPA5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001435008 -- 73,353,571(-) GGGG/GGGGG intron_variant
rs1002525626 -- 73,354,613(-) T/C upstream_transcript_variant
rs1002738363 -- 73,353,195(-) A/T 3_prime_UTR_variant
rs1003578524 -- 73,355,623(-) ATAA/ATAATAA upstream_transcript_variant
rs1003934147 -- 73,356,072(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DPPA5 Gene

Variant ID Type Subtype PubMed ID
nsv830693 CNV loss 17160897

Variation tolerance for DPPA5 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPPA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPPA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPPA5 Gene

Disorders for DPPA5 Gene

Additional Disease Information for DPPA5

No disorders were found for DPPA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPPA5 Gene

Publications for DPPA5 Gene

  1. Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. (PMID: 17913455) Pierre A … Monget P (Genomics 2007) 3 4 58
  2. Identification of developmental pluripotency associated 5 expression in human pluripotent stem cells. (PMID: 15790765) Kim SK … Kim KS (Stem cells (Dayton, Ohio) 2005) 3 4 58
  3. DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover. (PMID: 26661329) Qian X … Krebsbach PH (Stem cells (Dayton, Ohio) 2016) 3 58
  4. Generation of induced pluripotent stem cells from human adipose-derived stem cells without c-MYC. (PMID: 20146561) Aoki T … Ohgushi H (Tissue engineering. Part A 2010) 3 58
  5. Gene birth, death, and divergence: the different scenarios of reproduction-related gene evolution. (PMID: 19129511) Tian X … Monget P (Biology of reproduction 2009) 3 58

Products for DPPA5 Gene

Sources for DPPA5 Gene

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