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Aliases for DPPA5 Gene

Aliases for DPPA5 Gene

  • Developmental Pluripotency Associated 5 2 3 5
  • ESG1 3 4
  • Embryonal Stem Cell-Specific Gene 1 Protein 4
  • Embryonal Stem Cell Specific Gene 1 3
  • HDPPA5 4
  • ESG-1 4

External Ids for DPPA5 Gene

Previous GeneCards Identifiers for DPPA5 Gene

  • GC00U909478
  • GC06U900763
  • GC06M074120
  • GC06M074062
  • GC06M071261

Summaries for DPPA5 Gene

Entrez Gene Summary for DPPA5 Gene

  • This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]

GeneCards Summary for DPPA5 Gene

DPPA5 (Developmental Pluripotency Associated 5) is a Protein Coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for DPPA5 Gene

  • Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA5 Gene

Genomics for DPPA5 Gene

Regulatory Elements for DPPA5 Gene

Enhancers for DPPA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPPA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPPA5 Gene

73,353,062 bp from pter
73,354,295 bp from pter
1,234 bases
Minus strand

Genomic View for DPPA5 Gene

Genes around DPPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA5 Gene

Proteins for DPPA5 Gene

  • Protein details for DPPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Developmental pluripotency-associated 5 protein
    Protein Accession:
    Secondary Accessions:
    • B2RPQ7

    Protein attributes for DPPA5 Gene

    116 amino acids
    Molecular mass:
    13498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPPA5 Gene

Proteomics data for DPPA5 Gene at MOPED

Post-translational modifications for DPPA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPPA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DPPA5 Gene

Domains & Families for DPPA5 Gene

Protein Domains for DPPA5 Gene

Suggested Antigen Peptide Sequences for DPPA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KH domain.
  • Belongs to the KHDC1 family.
  • Contains 1 KH domain.
  • Belongs to the KHDC1 family.
genes like me logo Genes that share domains with DPPA5: view

No data available for Gene Families for DPPA5 Gene

Function for DPPA5 Gene

Molecular function for DPPA5 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in differentiated embryonic stem (ESC) cells, compared with strong expression in undifferentiated ESC cells.

Phenotypes for DPPA5 Gene

MGI mutant phenotypes for DPPA5:
inferred from 1 alleles
GenomeRNAi human phenotypes for DPPA5:
genes like me logo Genes that share phenotypes with DPPA5: view

Animal Models for DPPA5 Gene

MGI Knock Outs for DPPA5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPPA5 Gene

Localization for DPPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA5 Gene


Subcellular locations from

Jensen Localization Image for DPPA5 Gene COMPARTMENTS Subcellular localization image for DPPA5 gene
Compartment Confidence
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for DPPA5 Gene

Pathways & Interactions for DPPA5 Gene

SuperPathways for DPPA5 Gene

No Data Available

Interacting Proteins for DPPA5 Gene

Gene Ontology (GO) - Biological Process for DPPA5 Gene


No data available for Pathways by source and SIGNOR curated interactions for DPPA5 Gene

Drugs & Compounds for DPPA5 Gene

No Compound Related Data Available

Transcripts for DPPA5 Gene

mRNA/cDNA for DPPA5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DPPA5 Gene

Developmental pluripotency associated 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA5 Gene

No ASD Table

Relevant External Links for DPPA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPPA5 Gene

mRNA expression in normal human tissues for DPPA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPPA5 Gene

This gene is overexpressed in Testis (x32.1) and Ovary (x4.1).

SOURCE GeneReport for Unigene cluster for DPPA5 Gene Hs.125331

genes like me logo Genes that share expression patterns with DPPA5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DPPA5 Gene

Orthologs for DPPA5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia DPPA5 35
  • 84.2 (n)
  • 83.62 (a)
DPPA5 36
  • 84 (a)
(Mus musculus)
Mammalia Dppa5a 35
  • 77.38 (n)
  • 66.07 (a)
Dppa5a 16
Dppa5a 36
  • 63 (a)
Gm10112 36
  • 64 (a)
Gm5250 36
  • 61 (a)
(Pan troglodytes)
Mammalia DPPA5 35
  • 100 (n)
  • 100 (a)
DPPA5 36
  • 100 (a)
Species with no ortholog for DPPA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA5 Gene

Gene Tree for DPPA5 (if available)
Gene Tree for DPPA5 (if available)

Paralogs for DPPA5 Gene

(2) SIMAP similar genes for DPPA5 Gene using alignment to 1 proteins: Pseudogenes for DPPA5 Gene

genes like me logo Genes that share paralogs with DPPA5: view

No data available for Paralogs for DPPA5 Gene

Variants for DPPA5 Gene

Sequence variations from dbSNP and Humsavar for DPPA5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11756483 -- 73,352,789(+) TTTTC(A/G)GCTTA downstream-variant-500B
rs7742878 -- 73,355,215(+) TTAAT(A/T)TAGAA upstream-variant-2KB
rs12200929 -- 73,353,369(+) CAAGT(C/T)TGAGC reference, missense
rs511873 -- 73,352,693(+) AAAAA(A/G)AAAAG downstream-variant-500B
rs62440583 -- 73,354,464(+) TCTCC(A/G)AGTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPPA5 Gene

Variant ID Type Subtype PubMed ID
nsv830693 CNV Loss 17160897

Variation tolerance for DPPA5 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DPPA5 Gene

Disorders for DPPA5 Gene

Relevant External Links for DPPA5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DPPA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPPA5 Gene

Publications for DPPA5 Gene

  1. Atypical structure and phylogenomic evolution of the new eutherian oocyte-and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. (PMID: 17913455) Pierre A. … Monget P. (Genomics 2007) 3 4 67
  2. Generation of induced pluripotent stem cells from human adipose-derived stem cells without c-MYC. (PMID: 20146561) Aoki T. … Ohgushi H. (Tissue Eng Part A 2010) 3
  3. Gene birth, death, and divergence: the different scenarios of reproduction-related gene evolution. (PMID: 19129511) Tian X. … Monget P. (Biol. Reprod. 2009) 3
  4. The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation. (PMID: 19221495) Dansranjavin T. … Dammann R.H. (Cell Cycle 2009) 3
  5. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. (PMID: 17967063) Shen L. … Issa J.P. (PLoS Genet. 2007) 3

Products for DPPA5 Gene

Sources for DPPA5 Gene