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Aliases for DPPA4 Gene

Aliases for DPPA4 Gene

  • Developmental Pluripotency Associated 4 2 3
  • Developmental Pluripotency-Associated Protein 4 3
  • 2410091M23Rik 3

External Ids for DPPA4 Gene

Previous GeneCards Identifiers for DPPA4 Gene

  • GC00U909445
  • GC03M110365
  • GC03M110527
  • GC03M109045
  • GC03M106419

Summaries for DPPA4 Gene

GeneCards Summary for DPPA4 Gene

DPPA4 (Developmental Pluripotency Associated 4) is a Protein Coding gene. An important paralog of this gene is DPPA2.

UniProtKB/Swiss-Prot for DPPA4 Gene

  • May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA4 Gene

Genomics for DPPA4 Gene

Regulatory Elements for DPPA4 Gene

Genomic Location for DPPA4 Gene

Start:
109,326,141 bp from pter
End:
109,337,572 bp from pter
Size:
11,432 bases
Orientation:
Minus strand

Genomic View for DPPA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA4 Gene

Proteins for DPPA4 Gene

  • Protein details for DPPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L190-DPPA4_HUMAN
    Recommended name:
    Developmental pluripotency-associated protein 4
    Protein Accession:
    Q7L190
    Secondary Accessions:
    • A8K4M7
    • Q9H9N5
    • Q9NVI6

    Protein attributes for DPPA4 Gene

    Size:
    304 amino acids
    Molecular mass:
    33541 Da
    Quaternary structure:
    • Interacts with DPPA2.
    SequenceCaution:
    • Sequence=BAA91765.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14188.1; Type=Frameshift; Positions=148; Evidence={ECO:0000305};

neXtProt entry for DPPA4 Gene

Proteomics data for DPPA4 Gene at MOPED

Post-translational modifications for DPPA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPPA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPPA4 Gene

Domains for DPPA4 Gene

Protein Domains for DPPA4 Gene

Suggested Antigen Peptide Sequences for DPPA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DPPA4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DPPA4 Gene

Function for DPPA4 Gene

Molecular function for DPPA4 Gene

UniProtKB/Swiss-Prot Function: May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.

Gene Ontology (GO) - Molecular Function for DPPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with DPPA4: view
genes like me logo Genes that share phenotypes with DPPA4: view

Animal Models for DPPA4 Gene

MGI Knock Outs for DPPA4:

miRNA for DPPA4 Gene

miRTarBase miRNAs that target DPPA4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DPPA4 Gene

Localization for DPPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPPA4 Gene COMPARTMENTS Subcellular localization image for DPPA4 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for DPPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DPPA4: view

Pathways for DPPA4 Gene

SuperPathways for DPPA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0060484 lung-associated mesenchyme development IEA --
genes like me logo Genes that share ontologies with DPPA4: view

No data available for Pathways by source for DPPA4 Gene

Transcripts for DPPA4 Gene

Unigene Clusters for DPPA4 Gene

Developmental pluripotency associated 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for DPPA4 Gene

GeneLoc Exon Structure for
DPPA4
ECgene alternative splicing isoforms for
DPPA4

Expression for DPPA4 Gene

mRNA expression in normal human tissues for DPPA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPPA4 Gene

This gene is overexpressed in Testis (21.1) and Pituitary (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DPPA4 Gene

SOURCE GeneReport for Unigene cluster for DPPA4 Gene Hs.317659

genes like me logo Genes that share expressions with DPPA4: view

No data available for mRNA Expression by UniProt/SwissProt for DPPA4 Gene

Orthologs for DPPA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPPA4 35
  • 99.09 (n)
  • 98.3 (a)
DPPA4 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dppa4 35
  • 65.49 (n)
  • 55.99 (a)
Dppa4 16
Dppa4 36
  • 49 (a)
OneToMany
Gm5501 36
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC685378 35
  • 65.38 (n)
  • 56.64 (a)
Species with no ortholog for DPPA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA4 Gene

ENSEMBL:
Gene Tree for DPPA4 (if available)
TreeFam:
Gene Tree for DPPA4 (if available)

Paralogs for DPPA4 Gene

Paralogs for DPPA4 Gene

Selected SIMAP similar genes for DPPA4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DPPA4: view

Variants for DPPA4 Gene

Sequence variations from dbSNP and Humsavar for DPPA4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs15531 -- 109,326,660(+) AAAAC(A/T)GATCT utr-variant-3-prime
rs1044266 -- 109,326,208(-) CCCTG(C/T)TTCTA utr-variant-3-prime
rs1163438 -- 109,332,133(-) AGAGC(A/G)AGATT intron-variant
rs1163439 -- 109,329,081(-) GTCAG(A/G)TGGTG synonymous-codon, reference
rs1163440 -- 109,326,410(-) CCCGC(C/G)GTTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DPPA4 Gene

Variant ID Type Subtype PubMed ID
nsv829665 CNV Gain 17160897
nsv877330 CNV Gain 21882294
esv2421541 CNV Deletion 20811451
esv2725758 CNV Deletion 23290073
esv2725759 CNV Deletion 23290073
esv2725760 CNV Deletion 23290073

Relevant External Links for DPPA4 Gene

HapMap Linkage Disequilibrium report
DPPA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPPA4 Gene

Disorders for DPPA4 Gene

Relevant External Links for DPPA4

Genetic Association Database (GAD)
DPPA4
Human Genome Epidemiology (HuGE) Navigator
DPPA4
genes like me logo Genes that share disorders with DPPA4: view

No data available for UniProtKB/Swiss-Prot for DPPA4 Gene

Publications for DPPA4 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for DPPA4 Gene

Sources for DPPA4 Gene

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