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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DPPA4 Gene

protein-coding GIFtS: 51
GCID: GC03M109045

developmental pluripotency associated 4

Explore 2 diseases affiliated with
DPPA4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Developmental Pluripotency Associated 4¹ ²
FLJ10713¹
2410091M23Rik²
Developmental Pluripotency-Associated Protein 4²

External Ids:	HGNC: 19200¹	Entrez Gene: 55211²	Ensembl: ENSG00000121570⁷	OMIM: 614125⁵	UniProtKB: Q7L190³

Export aliases for DPPA4 gene to outside databases

Previous GC identifers: GC00U909445 GC03M110365 GC03M110527 GC03M106419

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DPPA4_HUMAN, Q7L190

Function: May be involved in the maintenance of active epigenetic status of target genes (By similarity). May inhibit

differentiation of embryonic cells into a primitive ectoderm lineage (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DPPA4 gene promoter:
Max1 AML1a COUP HNF-1A c-Ets-1 S8 POU2F1 COUP-TF POU2F1a HNF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DPPA4 promoter sequence

Search SABiosciences Chromatin IP Primers for DPPA4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPPA4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.13 Ensembl cytogenetic band: 3q13.13 HGNC cytogenetic band: 3q13.13

DPPA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPPA4 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M109045: view genomic region (about GC identifiers)

Start:	109,044,988 bp from pter	End:	109,056,419 bp from pter
Size:	11,432 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DPPA4_HUMAN, Q7L190 (See protein sequence)

Recommended Name: Developmental pluripotency-associated protein 4

Size: 304 amino acids; 33541 Da

Subunit: Interacts with DPPA2 (By similarity)

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAA91765.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB14188.1; Type=Frameshift; Positions=148;

Secondary accessions: A8K4M7 Q9H9N5 Q9NVI6

Explore the universe of human proteins at neXtProt for DPPA4: NX_Q7L190

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7L190

DPPA4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060659.3

ENSEMBL proteins:

ENSP00000335306 ENSP00000420581 ENSP00000418313

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals DPPA4 Protein Novus Biologicals DPPA4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DPPA4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

DPPA4 for ontologies About GeneDecksing

DPPA4 Antibody Products:

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	ThermoFisher Antibodies for DPPA4

Assay Products for DPPA4:

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	GenScript Custom Assay Services for DPPA4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DPPA4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DPPA4 for domains About GeneDecksing

2 InterPro domains/families:

IPR025892 Dppa2/4_central_dom

IPR025891 Dppa2/4_C_dom

Graphical View of Domain Structure for InterPro Entry Q7L190

ProtoNet protein and cluster: Q7L190

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DPPA4_HUMAN, Q7L190

Function: May be involved in the maintenance of active epigenetic status of target genes (By similarity). May inhibit

differentiation of embryonic cells into a primitive ectoderm lineage (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: DPPA4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPPA4
		1 QIAGEN miScript miRNA Assays for microRNA that regulate DPPA4:
		hsa-miR-3143
		SwitchGear 3'UTR luciferase reporter plasmid: DPPA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPPA4 (see all 4) OriGene shRNA RFP: DPPA4 OriGene siRNA: DPPA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPPA4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DPPA4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPPA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPPA4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DPPA4 (NM_018189)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPPA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPPA4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DPPA4
		Search LifeMap BioReagents cell lines for DPPA4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16169070

DPPA4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for DPPA4:

Decreased viability of wild-ty

Increased G1 DNA content

Animal Models:
Mouse knock-out Dppa4^tm1.1Yam for DPPA4
9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Dppa4):

cellular	growth/size	homeostasis/metabolism	mortality/aging	normal
other	reproductive system	respiratory system	skeleton

DPPA4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DPPA4

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/20 Interacting proteins for DPPA4 (Q7L190^{1, 2, 3} ENSP00000335306⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPRO	Q16827²^,³, ENSP00000281171⁴	MINT-8267654 I2D: score=2 STRING: ENSP00000281171
RPS6KB1	P23443²^,³, ENSP00000225577⁴	MINT-8270000 I2D: score=2 STRING: ENSP00000225577
SH3GL3	Q99963²^,³	MINT-64755 I2D: score=5
VIM	P08670²^,³	MINT-64754 I2D: score=5
DPPA2	Q7Z7J5²^,³	MINT-67879 I2D: score=4

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--

DPPA4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DPPA4
Search CenterWatch for drugs/clinical trials and news about DPPA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DPPA4 gene:

NM_018189.3

Unigene Cluster for DPPA4:

Developmental pluripotency associated 4

Hs.317659 [show with all ESTs]

Unigene Representative Sequence: NM_018189

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000335658(uc003dxq.4 uc011bho.2) ENST00000475135 ENST00000463966

ENST00000495679 ENST00000487299 ENST00000478791(uc011bhp.1) ENST00000477303

ENST00000489281

miRNA Products:		OriGene 3'-UTR Clone: DPPA4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPPA4
		1 QIAGEN miScript miRNA Assays for microRNA that regulate DPPA4:
		hsa-miR-3143
		SwitchGear 3'UTR luciferase reporter plasmid: DPPA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPPA4 (see all 4) OriGene shRNA RFP: DPPA4 OriGene siRNA: DPPA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPPA4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPPA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPPA4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DPPA4 (NM_018189)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPPA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPPA4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPPA4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat DPPA4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPPA4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPPA4

Additional cDNA sequence:

AK001575.1 AK290992.1 AK298623.1 AK299290.1 BC032846.2

8 DOTS entries:

DT.75101525 DT.92422517 DT.102842527 DT.102842530 DT.102842531 DT.100746751 DT.86837965 DT.91711140

24/87 AceView cDNA sequences (see all 87):

BX115701 AI342042 NM_018189 AU130753 AA219276 BX956210 AU135671 AU123850

AI992076 AA682843 AI650955 AA495991 BC018070 AW291865 BX956395 BF223616

AI656779 BX281871 AA226938 N32024 AA219141 CD048772 NM_138815 AA460929

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DPPA4 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6	^	7
SP1:									-		-
SP2:					-				-		-
SP3:
SP4:

ECgene alternative splicing isoforms for DPPA4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DPPA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATTTTAT

About this image

DPPA4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)

Early Embryo, Fibroblast

Induced pluripotent stem cells (using UTF1) (Induced Pluripotent Stem Cell)

Early Embryo, Fibroblast

BG01V (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H1 (WA01) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Induced pluripotent stem cell line 253G1 (Induced Pluripotent Stem Cell)

Early Embryo, Fibroblast

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Floating aggregates (A scalable, suspensi...)

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DPPA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPPA4

SOURCE GeneReport for Unigene cluster: Hs.317659

SABiosciences Custom PCR Arrays for DPPA4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPPA4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat DPPA4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPPA4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPPA4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for DPPA4 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dppa4^{1 , 5}	developmental pluripotency associated 4^{1, 5}	65.49(n)¹ 55.99(a)¹		16 (30.75 cM)⁵ 73693¹ NM_028610.2¹ NP_082886.2¹ 48283735⁵

ENSEMBL Gene Tree for DPPA4 (if available)
TreeFam Gene Tree for DPPA4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DPPA4 gene

DPPA2²

1 SIMAP similar gene for DPPA4 using alignment to 3 protein entries: DPPA4_HUMAN (see all proteins):

DPPA2

DPPA4 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for DPPA4
PGOHUM00000242365 PGOHUM00000237779 PGOHUM00000238051 PGOHUM00000245455 PGOHUM00000245456

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78128096^1,2		--	109044497(+)	`AAATTC/GCAATT`	1	--	ds500¹		1		NA	120
rs149518969^1,2		--	109044558(+)	`CAACAA/GTATGT`	1	--	ds500¹		0	--	--	--	--
rs79702263^1,2		--	109044560(+)	`ACAATA/GTGTTC`	1	--	ds500¹		4		CSA WA	122
rs55684296^1,2	C	--	109044580(+)	`GACCAA/GCGTTT`	1	--	ds500¹		0	--	--	--	--
rs180677139^1,2		--	109044587(+)	`GTTTAC/GCCTTG`	1	--	ds500¹		0	--	--	--	--
rs59257370^1,2	F,	--	109044622(+)	`CAAGAG/AAAATT`	1	--	ds500¹		1		EA	120
rs144015760^1,2		--	109044687(+)	`TTGTAC/TAAGTT`	1	--	ds500¹		0	--	--	--	--
rs148755518^1,2		--	109044747(+)	`TCCCCC/GCAAAA`	1	--	ds500¹		0	--	--	--	--
rs1163441^1,2	C,F,O,A,H,	--	109044830(-)	`AGAATA/GCTAAG`	1	--	ds500¹		32		MN NA NS EA WA CSA	2447
rs6437837^1,2	C,F,A,H,	--	109044834(+)	`GCATTC/GTGGGA`	1	--	ds500¹		8		NS EA WA CSA	541

HapMap Linkage Disequilibrium report for DPPA4 (109044988 - 109056419 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DPPA4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPPA4

DNA2.0 Custom Variant and Variant Library Synthesis for DPPA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DPPA4 for disorders           About GeneDecksing

OMIM gene information: 614125    OMIM disorders: --

2 diseases for DPPA4:    About MalaCards

embryonal carcinoma carcinoma

Human Genome Epidemiology (HuGE) Navigator: DPPA4 (3 documents)

Export disorders for DPPA4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DPPA4 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with DPPA4)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. (PubMed id 21348951)¹ Parsa A....Liggett S.B. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays. (PubMed id 18366076)¹ Chakravarthy H....Rizzino A. (2008)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55211	HGNC: 19200	AceView: DPPA4	Ensembl:ENSG00000121570	euGenes: HUgn55211
ECgene: DPPA4	H-InvDB: DPPA4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DPPA4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DPPA4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DPPA4 gene:
Search GeneIP for patents involving DPPA4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Custom Antibody & Bulk Services
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	Antibodies for DPPA4 (DPPA4)		Browse Cell Culture Products
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	OriGene Antibodies for DPPA4		OriGene shRNA RFP for DPPA4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPPA4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPPA4
	OriGene Protein Over-expression Lysate for DPPA4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DPPA4		OriGene 3'-UTR Clone for DPPA4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPPA4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPPA4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DPPA4		OriGene Custom Protein Services for DPPA4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPPA4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPPA4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPPA4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPPA4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPPA4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPPA4

	GenScript Custom Purified and Recombinant Proteins Services for DPPA4		GenScript cDNA clones with any tag delivered in your preferred vector for DPPA4
	GenScript Custom Assay Services for DPPA4		GenScript Custom Superior Antibodies Services for DPPA4
	GenScript Custom overexpressing Cell Line Services for DPPA4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in DPPA4 promoter
	Search Chromatin IP Primers for DPPA4
	RT² qPCR Primer Assay in human, mouse / rat DPPA4
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	SABiosciences Custom PCR Arrays for DPPA4

Search Tocris compounds for DPPA4

	Browse Sino Biological Proteins and Antibodies
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DPPA4 antibodies
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	DPPA4 lysates

	Antibodies for DPPA4
	See all of Abcam's Antibodies, Kits and Proteins for DPPA4
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Browse ProSpec Recombinant Proteins

DPPA4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DPPA4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA4

	SwitchGear 3'UTR luciferase reporter plasmids for DPPA4
	SwitchGear Promoter luciferase reporter plasmids for DPPA4

ThermoFisher Antibodies for DPPA4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPPA4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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DPPA4 Gene

developmental pluripotency associated 4

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DPPA4 Gene

developmental pluripotency associated 4

Aliasesfor DPPA4 gene

Summariesfor DPPA4 gene

Genomic Viewsfor DPPA4 gene

Proteinsfor DPPA4 gene

Protein Domains /Familiesfor DPPA4 gene

Functionfor DPPA4 gene

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Genome Databases showing DPPA4 gene

Other Databases showing DPPA4 gene

Specialized Databases showing DPPA4 gene

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Aliases
for DPPA4 gene

Summaries
for DPPA4 gene

Genomic Views
for DPPA4 gene

Proteins
for DPPA4 gene

Protein Domains /
Families
for DPPA4 gene

Function
for DPPA4 gene

Pathways & Interactions
for DPPA4 gene

Drugs & Compounds
for DPPA4 gene

Transcripts
for DPPA4 gene

Expression
for DPPA4 gene

Orthologs
for DPPA4 gene

Paralogs
for DPPA4 gene

Genomic Variants
for DPPA4 gene

Disorders / Diseases
for DPPA4 gene

Publications
for DPPA4 gene

Intellectual Property
for DPPA4 gene

Products
for DPPA4 gene