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Aliases for DPPA4 Gene

Aliases for DPPA4 Gene

  • Developmental Pluripotency Associated 4 2 3 5
  • 2410091M23Rik 3

External Ids for DPPA4 Gene

Previous GeneCards Identifiers for DPPA4 Gene

  • GC00U909445
  • GC03M110365
  • GC03M110527
  • GC03M109045
  • GC03M106419

Summaries for DPPA4 Gene

GeneCards Summary for DPPA4 Gene

DPPA4 (Developmental Pluripotency Associated 4) is a Protein Coding gene. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Developmental Biology. An important paralog of this gene is DPPA2.

UniProtKB/Swiss-Prot for DPPA4 Gene

  • May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA4 Gene

Genomics for DPPA4 Gene

Regulatory Elements for DPPA4 Gene

Enhancers for DPPA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPPA4 on UCSC Golden Path with GeneCards custom track

Promoters for DPPA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPPA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPPA4 Gene

109,326,141 bp from pter
109,337,572 bp from pter
11,432 bases
Minus strand

Genomic View for DPPA4 Gene

Genes around DPPA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPPA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA4 Gene

Proteins for DPPA4 Gene

  • Protein details for DPPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Developmental pluripotency-associated protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K4M7
    • Q9H9N5
    • Q9NVI6

    Protein attributes for DPPA4 Gene

    304 amino acids
    Molecular mass:
    33541 Da
    Quaternary structure:
    • Interacts with DPPA2 (By similarity). Interacts with PCGF1 (PubMed:26687479).
    • Sequence=BAA91765.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14188.1; Type=Frameshift; Positions=148; Evidence={ECO:0000305};

neXtProt entry for DPPA4 Gene

Proteomics data for DPPA4 Gene at MOPED

Post-translational modifications for DPPA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPPA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPPA4 Gene

Domains & Families for DPPA4 Gene

Protein Domains for DPPA4 Gene

Suggested Antigen Peptide Sequences for DPPA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DPPA4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DPPA4 Gene

Function for DPPA4 Gene

Molecular function for DPPA4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.
genes like me logo Genes that share phenotypes with DPPA4: view

Animal Models for DPPA4 Gene

MGI Knock Outs for DPPA4:

Animal Model Products

miRNA for DPPA4 Gene

miRTarBase miRNAs that target DPPA4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPPA4 Gene

Localization for DPPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA4 Gene

Nucleus. Note=Associated with transcriptionally active chromatin. {ECO:0000250 UniProtKB:Q8CCG4}.

Subcellular locations from

Jensen Localization Image for DPPA4 Gene COMPARTMENTS Subcellular localization image for DPPA4 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DPPA4 Gene

Pathways & Interactions for DPPA4 Gene

genes like me logo Genes that share pathways with DPPA4: view

Gene Ontology (GO) - Biological Process for DPPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DPPA4: view

No data available for SIGNOR curated interactions for DPPA4 Gene

Drugs & Compounds for DPPA4 Gene

No Compound Related Data Available

Transcripts for DPPA4 Gene

Unigene Clusters for DPPA4 Gene

Developmental pluripotency associated 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - -

Relevant External Links for DPPA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPPA4 Gene

mRNA expression in normal human tissues for DPPA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPPA4 Gene

This gene is overexpressed in Testis (x21.1) and Pituitary (x7.6).

Protein differential expression in normal tissues from HIPED for DPPA4 Gene

This gene is overexpressed in Lung (41.4) and Blymphocyte (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPPA4 Gene

SOURCE GeneReport for Unigene cluster for DPPA4 Gene Hs.317659

genes like me logo Genes that share expression patterns with DPPA4: view

Protein tissue co-expression partners for DPPA4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DPPA4 Gene

Orthologs for DPPA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Dppa4 35
  • 65.49 (n)
  • 55.99 (a)
Dppa4 16
Dppa4 36
  • 49 (a)
Gm5501 36
  • 49 (a)
(Pan troglodytes)
Mammalia DPPA4 35
  • 99.09 (n)
  • 98.3 (a)
DPPA4 36
  • 96 (a)
(Rattus norvegicus)
Mammalia LOC685378 35
  • 65.38 (n)
  • 56.64 (a)
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
-- 36
  • 53 (a)
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
-- 36
  • 56 (a)
-- 36
  • 65 (a)
-- 36
  • 60 (a)
-- 36
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
Species with no ortholog for DPPA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA4 Gene

Gene Tree for DPPA4 (if available)
Gene Tree for DPPA4 (if available)

Paralogs for DPPA4 Gene

Paralogs for DPPA4 Gene

(1) SIMAP similar genes for DPPA4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DPPA4: view

Variants for DPPA4 Gene

Sequence variations from dbSNP and Humsavar for DPPA4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3762648 - 109,333,885(-) TGTCT(A/G)TCAAA reference, missense
rs3905734 - 109,330,526(-) GGCCT(C/T)TGGTA reference, missense
rs15531 -- 109,326,660(+) AAAAC(A/T)GATCT utr-variant-3-prime
rs1044266 -- 109,326,208(-) CCCTG(C/T)TTCTA utr-variant-3-prime
rs1163438 -- 109,332,133(-) AGAGC(A/G)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPPA4 Gene

Variant ID Type Subtype PubMed ID
nsv829665 CNV Gain 17160897
nsv877330 CNV Gain 21882294
esv2421541 CNV Deletion 20811451
esv2725758 CNV Deletion 23290073
esv2725759 CNV Deletion 23290073
esv2725760 CNV Deletion 23290073

Variation tolerance for DPPA4 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DPPA4 Gene

Disorders for DPPA4 Gene

Relevant External Links for DPPA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DPPA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPPA4 Gene

Publications for DPPA4 Gene

  1. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3
  5. Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. (PMID: 23761726) Yazar S. … Hewitt A.W. (Mol. Vis. 2013) 3

Products for DPPA4 Gene

Sources for DPPA4 Gene