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DPPA3 Gene

protein-coding   GIFtS: 46
GCID: GC12P007864

Developmental Pluripotency Associated 3

  See DPPA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Developmental Pluripotency Associated 31 2
Stella-Related Protein2 3
STELLA2
Developmental Pluripotency-Associated Protein 32
STELLAR3

External Ids:    HGNC: 191991   Entrez Gene: 3597872   Ensembl: ENSG000001875697   OMIM: 6084085   UniProtKB: Q6W0C53   

Export aliases for DPPA3 gene to outside databases

Previous GC identifers: GC00U909444 GC12U900415 GC12P007757 GC12P007678


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPPA3 Gene:
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of
development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of
cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DPPA3 Gene:
DPPA3 (developmental pluripotency associated 3) is a protein-coding gene. Diseases associated with DPPA3 include germ cell tumors. GO annotations related to this gene include methylated histone residue binding.

UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5
Function: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the
zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus
before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are
protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by
preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9'
(H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent
DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain
much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA
demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through
preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity)

Gene Wiki entry for DPPA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPPA3 gene promoter:
         SREBP-1c   Nkx2-5   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   LUN-1   POU3F2   SREBP-1b   SREBP-1a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPPA3 promoter sequence
   Search Chromatin IP Primers for DPPA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPPA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

DPPA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPPA3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007864:  view genomic region     (about GC identifiers)

Start:
7,864,050 bp from pter      End:
7,870,155 bp from pter
Size:
6,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5 (See protein sequence)
Recommended Name: Developmental pluripotency-associated protein 3  
Size: 159 amino acids; 17851 Da
Developmental stage: Expressed in fetal ovary
Secondary accessions: Q0P5U3 Q6JZS6

Explore the universe of human proteins at neXtProt for DPPA3: NX_Q6W0C5

Explore proteomics data for DPPA3 at MOPED


See DPPA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_954980.1  
ENSEMBL proteins: 
 ENSP00000339250  

DPPA3 Human Recombinant Protein Products:

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antibodies-online proteins for DPPA3 (4 products) 

 
antibodies-online peptides for DPPA3

DPPA3 Antibody Products:

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antibodies-online antibodies for DPPA3 (24 products) 

DPPA3 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6W0C5

UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5
Domain: Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal
pronucleus requires the C-terminal part (By similarity)


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DPPA3_HUMAN, Q6W0C5
Function: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the
zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus
before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are
protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by
preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9'
(H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent
DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain
much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA
demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through
preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0035064methylated histone residue binding ISS--
     
Find genes that share ontologies with DPPA3           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for DPPA3:
 Synthetic lethal with Ras 

     6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dppa3):
 cellular  embryogenesis  mortality/aging  no phenotypic analysis  other 
 reproductive system 

Find genes that share phenotypes with DPPA3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Dppa3tm1Dcp for DPPA3

   genOway: Develop your customized and physiologically relevant rodent model for DPPA3

miRNA
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1 qRT-PCR Assays for microRNA that regulate DPPA3:
hsa-miR-888
SwitchGear 3'UTR luciferase reporter plasmidDPPA3 3' UTR sequence
Inhib. RNA
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Flow Cytometry
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DPPA3_HUMAN, Q6W0C5: Nucleus. Cytoplasm. Note=Mainly localizes in the female pronucleus, localization to the male
pronucleus in much weaker (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001939female pronucleus ISS--
GO:0001940NOT male pronucleus ISS--
GO:0005634nucleus IDA--
GO:0005737cytoplasm IDA--

Find genes that share ontologies with DPPA3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPPA3
Interactions:

    Search GeneGlobe Interaction Network for DPPA3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for DPPA3 (Q6W0C53 ENSP000003392504) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IPO5O004103, ENSP000002615744I2D: score=1 STRING: ENSP00000261574
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016568chromatin modification IEA--
GO:0040016embryonic cleavage IEA--
GO:0044726protection of DNA demethylation of female pronucleus ISS--
GO:1901536negative regulation of DNA demethylation ISS--
GO:2000653regulation of genetic imprinting ISS--

Find genes that share ontologies with DPPA3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DPPA3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DPPA3 gene: 
NM_199286.2  

Unigene Cluster for DPPA3:

Developmental pluripotency associated 3
Hs.131358  [show with all ESTs]
Unigene Representative Sequence: AY317075
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000345088(uc001qtf.3)
miRNA
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1 qRT-PCR Assays for microRNA that regulate DPPA3:
hsa-miR-888
SwitchGear 3'UTR luciferase reporter plasmidDPPA3 3' UTR sequence
Inhib. RNA
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Primer
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Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA4-14122) for DPPA3 

Additional mRNA sequence: AY317075.1 

2 DOTS entries:

DT.104320  DT.97809681 

17 AceView cDNA sequences:

NM_199286 AY317075 AI948852 BX095425 AI650531 AI990772 BE466414 AA927342 
AA564230 BV205587 AW002433 AI066520 AA864924 AI954611 AI651977 BQ028671 
AA300687 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DPPA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DPPA3 Expression
About this image


DPPA3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Gonad
         Primordial Germ Cells Allantois
         Human oogonial stem cells
 
 Ovary (Reproductive System)    fully expand to see all 6 entries
         Secondary Oocyte Antral Follicle
         Ovarian tissue-dissociated cells (human)
 
 Germ Cells (Reproductive System)    fully expand to see all 3 entries
         Human oogonial stem cells
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
         Inner Cell Mass Cells Inner Cell Mass
         ES-J1
 
 Placenta (Extraembryonic Tissues)
         Primordial Germ Cells Allantois
DPPA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DPPA3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.131358

UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5
Tissue specificity: Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells.
Highly expressed in testicular germ cell tumors

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for DPPA3 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dppa35 developmental pluripotency-associated 3   --   6 (57.72 cM) 122626410 


ENSEMBL Gene Tree for DPPA3 (if available)
TreeFam Gene Tree for DPPA3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DPPA3 gene

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Selected Pseudogenes.org Pseudogenes for DPPA3 (see all 22)
PGOHUM00000238637 PGOHUM00000239892 PGOHUM00000248447 PGOHUM00000248908 PGOHUM00000248972


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DPPA3 (see all 211)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs23768991,2
C,F--7862134(-) TAGCCG/AGGCAT 1 -- us2k17Minor allele frequency- A:0.14WA NA CSA EA 365
rs1465211501,2
--7862212(+) GATCTC/TGGCTC 1 -- us2k10--------
rs1922673641,2
--7862220(+) CTCACC/TGCAAC 1 -- us2k10--------
rs1838384291,2
C--7862423(+) CAGGCA/GTGAGC 1 -- us2k10--------
rs71330111,2
C,F--7862538(+) cctccC/Taaagt 1 -- us2k11Minor allele frequency- T:0.50NA 2
rs1895876721,2
--7862540(+) TCCCAA/GAGTGC 1 -- us2k10--------
rs107726501,2
C,F,A,H--7862625(+) TATCTC/TACCTC 1 -- us2k1 tfbs321Minor allele frequency- T:0.28NS EA NA CSA WA 2526
rs1433777511,2
--7862830(+) TCTGGG/TTCTTC 1 -- us2k10--------
rs2014463171,2
--7862967(+) CTGCA-/CCTTTT 1 -- us2k10--------
rs72980561,2
C--7862969(+) TGCACC/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.50NA 2

HapMap Linkage Disequilibrium report for DPPA3 (7864050 - 7870155 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for DPPA3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422393CNV Duplication17116639
dgv6e196CNV Duplication17116639
dgv5e196CNV Duplication17116639
nsv428270CNV Gain18775914
dgv57e55CNV Gain17911159
dgv454e1CNV Complex17122850
dgv455e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DPPA3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608408    OMIM disorders: --

1 disease for DPPA3:    
About MalaCards
germ cell tumors


Find genes that share disorders with DPPA3           About GenesLikeMe


Export disorders for DPPA3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DPPA3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with DPPA3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (PubMed id 14990856)1, 2 Clark A.T.... Reijo Pera R.A. (Stem Cells 2004)
  3. Stella is a maternal effect gene required for normal early development in mice. (PubMed id 14654002)1, 2 Payer B.... Surani M.A. (Curr. Biol. 2003)
  4. Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. (PubMed id 14684992)1, 2 Bowles J.... Koopman P. (Cytogenet. Genome Res. 2003)
  5. STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells. (PubMed id 23457636)1 Wongtrakoongate P....Andrews P.W. (PLoS ONE 2013)
  6. NANOS3 function in human germ cell development. (PubMed id 21421998)2 Julaton V.T. and Reijo Pera R.A. (Hum. Mol. Genet. 2011)
  7. PGC7/Stella protects against DNA demethylation in early embryogenesis. (PubMed id 17143267)1 Nakamura T....Nakano T. (Nat. Cell Biol. 2007)
  8. Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. (PubMed id 16291741)1 Elliman S.J....Kemp D.M. (J. Biol. Chem. 2006)
  9. Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. (PubMed id 15018652)1 Bortvin A....Page D.C. (BMC Dev. Biol. 2004)
  10. Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. (PubMed id 11900980)1 Sato M....Nakano T. (Mech. Dev. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 359787 HGNC: 19199 AceView: DPPA3 Ensembl:ENSG00000187569 euGenes: HUgn359787
ECgene: DPPA3 H-InvDB: DPPA3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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PharmGKB entry for DPPA3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DPPA3 gene:
Search GeneIP for patents involving DPPA3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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