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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPPA3 Gene

protein-coding   GIFtS: 47
GCID: GC12P007864

Developmental Pluripotency Associated 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Developmental Pluripotency Associated 31 2
Stella-Related Protein2 3
STELLA2
Developmental Pluripotency-Associated Protein 32
STELLAR3

External Ids:    HGNC: 191991   Entrez Gene: 3597872   Ensembl: ENSG000001875697   OMIM: 6084085   UniProtKB: Q6W0C53   

Export aliases for DPPA3 gene to outside databases

Previous GC identifers: GC00U909444 GC12U900415 GC12P007757 GC12P007678


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPPA3 Gene:
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of
development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of
cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DPPA3 Gene: 
DPPA3 (developmental pluripotency associated 3) is a protein-coding gene. Diseases associated with DPPA3 include germ cell tumors, and teratoma. GO annotations related to this gene include methylated histone residue binding.

UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5
Function: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the
zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus
before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are
protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by
preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9'
(H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent
DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain
much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA
demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through
preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity)

Gene Wiki entry for DPPA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPPA3 gene promoter:
         SREBP-1c   Nkx2-5   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   LUN-1   POU3F2   SREBP-1b   SREBP-1a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPPA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPPA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPPA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

DPPA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPPA3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007864:  view genomic region     (about GC identifiers)

Start:
7,864,050 bp from pter      End:
7,870,155 bp from pter
Size:
6,106 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5 (See protein sequence)
Recommended Name: Developmental pluripotency-associated protein 3  
Size: 159 amino acids; 17851 Da
Subcellular location: Nucleus. Cytoplasm. Note=Mainly localizes in the female pronucleus, localization to the male
pronucleus in much weaker (By similarity)
Developmental stage: Expressed in fetal ovary
Secondary accessions: Q0P5U3 Q6JZS6

Explore the universe of human proteins at neXtProt for DPPA3: NX_Q6W0C5

Explore proteomics data for DPPA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6W0C5

  • DPPA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPPA3 Protein Expression
    REFSEQ proteins: NP_954980.1  
    ENSEMBL proteins: 
     ENSP00000339250  

    Human Recombinant Protein Products for DPPA3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals DPPA3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DPPA3
    Cloud-Clone Corp. Proteins for DPPA3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001939female pronucleus ISS--
    GO:0001940NOT male pronucleus ISS--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    DPPA3 for ontologies           About GeneDecksing



    DPPA3 Antibody Products: 
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    R&D Systems Antibodies for DPPA3 (Stella/Dppa3)
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    Novus Biologicals DPPA3 Antibody
    Abcam antibodies for DPPA3
    Cloud-Clone Corp. Antibodies for DPPA3 
    Search ThermoFisher Antibodies for DPPA3
    LSBio Antibodies in human, mouse, rat for DPPA3 

    Assay Products for DPPA3: 
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    Cloud-Clone Corp. ELISAs for DPPA3 
    Cloud-Clone Corp. CLIAs for DPPA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6W0C5

    UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5
    Domain: Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal
    pronucleus requires the C-terminal part (By similarity)


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPPA3_HUMAN, Q6W0C5
    Function: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the
    zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus
    before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are
    protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by
    preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9'
    (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent
    DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain
    much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA
    demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through
    preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0035064methylated histone residue binding ISS--
         
    DPPA3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DPPA3:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dppa3):
     cellular  embryogenesis  mortality/aging  no phenotypic analysis  other 
     reproductive system 

    DPPA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dppa3tm1Dcp for DPPA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPPA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DPPA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPPA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPPA3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPPA3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DPPA3:
    hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidDPPA3 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of DPPA3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPPA3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DPPA3 (Q6W0C53 ENSP000003392504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IPO5O004103, ENSP000002615744I2D: score=1 STRING: ENSP00000261574
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016568chromatin modification IEA--
    GO:0040016embryonic cleavage IEA--
    GO:0044726protection of DNA demethylation of female pronucleus ISS--
    GO:1901536negative regulation of DNA demethylation ISS--
    GO:2000653regulation of genetic imprinting ISS--

    DPPA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPPA3

    Search CenterWatch for drugs/clinical trials and news about DPPA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPPA3 gene: 
    NM_199286.2  

    Unigene Cluster for DPPA3:

    Developmental pluripotency associated 3
    Hs.131358  [show with all ESTs]
    Unigene Representative Sequence: AY317075
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000345088(uc001qtf.3)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate DPPA3:
    hsa-miR-888
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPPA3
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    GenScript: all cDNA clones in your preferred vector: DPPA3 (NM_199286)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPPA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPPA3
    Sirion Biotech Customized lentivirus for stable overexpression of DPPA3 
                         Customized lentivirus expression plasmids for stable overexpression of DPPA3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DPPA3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPPA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPPA3

    Additional mRNA sequence: AY317075.1 

    2 DOTS entries:

    DT.104320  DT.97809681 

    17 AceView cDNA sequences:

    AI948852 AI990772 AA927342 AY317075 BE466414 NM_199286 BX095425 AI650531 
    AI066520 AA864924 AA564230 AI954611 AW002433 BV205587 AI651977 AA300687 
    BQ028671 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPPA3 expression in normal human tissues (normalized intensities)      DPPA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DPPA3 Expression
    About this image


    DPPA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 6 entries
             Secondary Oocyte Antral Follicle
             Ovarian tissue-dissociated cells (human)
     
     Gonad
             Primordial Germ Cells Allantois
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Inner Cell Mass Cells Inner Cell Mass
             ES-J1
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme

    See DPPA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPPA3

    SOURCE GeneReport for Unigene cluster: Hs.131358

    UniProtKB/Swiss-Prot: DPPA3_HUMAN, Q6W0C5
    Tissue specificity: Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells.
    Highly expressed in testicular germ cell tumors

        SABiosciences Custom PCR Arrays for DPPA3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for DPPA3 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dppa35 developmental pluripotency-associated 3   --   6 (57.72 cM) 122626410 


    ENSEMBL Gene Tree for DPPA3 (if available)
    TreeFam Gene Tree for DPPA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPPA3 gene

    DPPA3 for paralogs           About GeneDecksing


    5/22 Pseudogenes.org Pseudogenes for DPPA3 (see all 22)
    PGOHUM00000238637 PGOHUM00000239892 PGOHUM00000248447 PGOHUM00000248908 PGOHUM00000248972


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 SNPs in DPPA3 are shown (see all 211)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23768991,2
    C,F--7862134(-) TAGCCG/AGGCAT 1 -- us2k17Minor allele frequency- A:0.14WA NA CSA EA 365
    rs1465211501,2
    --7862212(+) GATCTC/TGGCTC 1 -- us2k10--------
    rs1922673641,2
    --7862220(+) CTCACC/TGCAAC 1 -- us2k10--------
    rs1838384291,2
    C--7862423(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs71330111,2
    C,F--7862538(+) cctccC/Taaagt 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1895876721,2
    --7862540(+) TCCCAA/GAGTGC 1 -- us2k10--------
    rs107726501,2
    C,F,A,H--7862625(+) TATCTC/TACCTC 1 -- us2k1 tfbs321Minor allele frequency- T:0.28NS EA NA CSA WA 2526
    rs1433777511,2
    --7862830(+) TCTGGG/TTCTTC 1 -- us2k10--------
    rs2014463171,2
    --7862967(+) CTGCA-/CCTTTT 1 -- us2k10--------
    rs72980561,2
    C--7862969(+) TGCACC/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for DPPA3 (7864050 - 7870155 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DPPA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422393CNV Duplication17116639
    dgv6e196CNV Duplication17116639
    dgv5e196CNV Duplication17116639
    nsv428270CNV Gain18775914
    dgv57e55CNV Gain17911159
    dgv454e1CNV Complex17122850
    dgv455e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DPPA3
    DNA2.0 Custom Variant and Variant Library Synthesis for DPPA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608408    OMIM disorders: --

    4 diseases for DPPA3:    About MalaCards
    germ cell tumors    teratoma    seminoma    teratocarcinoma


    DPPA3 for disorders           About GeneDecksing


    Export disorders for DPPA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPPA3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DPPA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. (PubMed id 14990856)1, 2 Clark A.T.... Reijo Pera R.A. (2004)
    3. Stella is a maternal effect gene required for normal early development in mice. (PubMed id 14654002)1, 2 Payer B.... Surani M.A. (2003)
    4. Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. (PubMed id 14684992)1, 2 Bowles J....Koopman P. (2003)
    5. STELLA facilitates differentiation of germ cell and en dodermal lineages of human embryonic stem cells. (PubMed id 23457636)1 Wongtrakoongate P....Andrews P.W. (2013)
    6. NANOS3 function in human germ cell development. (PubMed id 21421998)2 Julaton V.T. and Reijo Pera R.A. (2011)
    7. PGC7/Stella protects against DNA demethylation in early embryogenesis. (PubMed id 17143267)1 Nakamura T....Nakano T. (2007)
    8. Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. (PubMed id 16291741)1 Elliman S.J....Kemp D.M. (2006)
    9. Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. (PubMed id 15018652)1 Bortvin A....Page D.C. (2004)
    10. Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. (PubMed id 11900980)1 Sato M....Nakano T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 359787 HGNC: 19199 AceView: DPPA3 Ensembl:ENSG00000187569 euGenes: HUgn359787
    ECgene: DPPA3 H-InvDB: DPPA3

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for DPPA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for DPPA3 gene:
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