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Aliases for DPPA2 Gene

Aliases for DPPA2 Gene

  • Developmental Pluripotency Associated 2 2 3 5
  • Pluripotent Embryonic Stem Cell-Related Gene 1 Protein 3 4
  • Cancer/Testis Antigen 100 2 3
  • PESCRG1 3 4
  • Embryonic Stem Cell (ESC) Associated Transcript 15-2 3
  • ECAT15-2 3
  • CT100 3

External Ids for DPPA2 Gene

Previous GeneCards Identifiers for DPPA2 Gene

  • GC00U909443
  • GC03M110496
  • GC03M109012
  • GC03M106386

Summaries for DPPA2 Gene

GeneCards Summary for DPPA2 Gene

DPPA2 (Developmental Pluripotency Associated 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is DPPA4.

UniProtKB/Swiss-Prot for DPPA2 Gene

  • Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.

Gene Wiki entry for DPPA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA2 Gene

Genomics for DPPA2 Gene

Regulatory Elements for DPPA2 Gene

Enhancers for DPPA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPPA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPPA2 Gene

109,293,788 bp from pter
109,316,535 bp from pter
22,748 bases
Minus strand

Genomic View for DPPA2 Gene

Genes around DPPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA2 Gene

Proteins for DPPA2 Gene

  • Protein details for DPPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Developmental pluripotency-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8WVF0

    Protein attributes for DPPA2 Gene

    298 amino acids
    Molecular mass:
    33784 Da
    Quaternary structure:
    • Interacts with DPPA4.

neXtProt entry for DPPA2 Gene

Proteomics data for DPPA2 Gene at MOPED

Post-translational modifications for DPPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPPA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DPPA2 Gene

Domains & Families for DPPA2 Gene

Protein Domains for DPPA2 Gene

Suggested Antigen Peptide Sequences for DPPA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAP domain.
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with DPPA2: view

No data available for Gene Families for DPPA2 Gene

Function for DPPA2 Gene

Molecular function for DPPA2 Gene

UniProtKB/Swiss-Prot Function:
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.
genes like me logo Genes that share phenotypes with DPPA2: view

Animal Models for DPPA2 Gene

MGI Knock Outs for DPPA2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPPA2 Gene

Localization for DPPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA2 Gene

Subcellular locations from

Jensen Localization Image for DPPA2 Gene COMPARTMENTS Subcellular localization image for DPPA2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for DPPA2 Gene

Pathways & Interactions for DPPA2 Gene

SuperPathways for DPPA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0019827 stem cell population maintenance IEA --
GO:0031060 regulation of histone methylation IEA --
genes like me logo Genes that share ontologies with DPPA2: view

No data available for Pathways by source and SIGNOR curated interactions for DPPA2 Gene

Drugs & Compounds for DPPA2 Gene

No Compound Related Data Available

Transcripts for DPPA2 Gene

mRNA/cDNA for DPPA2 Gene

Unigene Clusters for DPPA2 Gene

Developmental pluripotency associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA2 Gene

No ASD Table

Relevant External Links for DPPA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPPA2 Gene

mRNA expression in normal human tissues for DPPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPPA2 Gene

This gene is overexpressed in Testis (x48.8).

Protein differential expression in normal tissues from HIPED for DPPA2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPPA2 Gene

SOURCE GeneReport for Unigene cluster for DPPA2 Gene Hs.351113

mRNA Expression by UniProt/SwissProt for DPPA2 Gene

Tissue specificity: Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues.
genes like me logo Genes that share expression patterns with DPPA2: view

Protein tissue co-expression partners for DPPA2 Gene

Primer Products

Orthologs for DPPA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DPPA2 35
  • 74.44 (n)
  • 60.78 (a)
-- 36
  • 57 (a)
DPPA2 36
  • 50 (a)
(Mus musculus)
Mammalia Dppa2 35
  • 60.45 (n)
  • 47.54 (a)
Dppa2 16
Dppa2 36
  • 43 (a)
(Pan troglodytes)
Mammalia DPPA2 35
  • 99.55 (n)
  • 99.66 (a)
DPPA2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC683282 35
  • 66.1 (n)
  • 51.14 (a)
(Canis familiaris)
Mammalia -- 36
  • 59 (a)
-- 36
  • 56 (a)
-- 36
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
Species with no ortholog for DPPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA2 Gene

Gene Tree for DPPA2 (if available)
Gene Tree for DPPA2 (if available)

Paralogs for DPPA2 Gene

Paralogs for DPPA2 Gene

(1) SIMAP similar genes for DPPA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPPA2: view

Variants for DPPA2 Gene

Sequence variations from dbSNP and Humsavar for DPPA2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9809030 - 109,309,030(+) CTTGC(C/T)GTTGT reference, missense
rs1163444 -- 109,315,863(-) ttcat(A/G)gagat intron-variant, upstream-variant-2KB
rs1163445 -- 109,315,528(-) GCTTC(A/G)TATTT intron-variant, upstream-variant-2KB
rs1163446 -- 109,314,053(-) CTTTC(A/G)GAGTA intron-variant
rs7611135 -- 109,308,310(+) ATTCA(C/T)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPPA2 Gene

Variant ID Type Subtype PubMed ID
nsv829665 CNV Gain 17160897
nsv877329 CNV Loss 21882294

Variation tolerance for DPPA2 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DPPA2 Gene

Disorders for DPPA2 Gene

Relevant External Links for DPPA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DPPA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPPA2 Gene

Publications for DPPA2 Gene

  1. Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell. (PMID: 15583978) Du J. … Lu G.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004) 2 3 4 67
  2. Diagnostic clinical relevance of developmental pluripotency-associated 2 (DPPA2) in colorectal cancer. (PMID: 25497006) Ghodsi M. … Forghanifard M.M. (Int J Surg 2015) 3
  3. Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis. (PMID: 24532429) Raeisossadati R. … Forghanifard M.M. (Tumour Biol. 2014) 3
  4. Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. (PMID: 23761726) Yazar S. … Hewitt A.W. (Mol. Vis. 2013) 3
  5. Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes. (PMID: 23963736) Tung P.Y. … Knoepfler P.S. (Stem Cells 2013) 3

Products for DPPA2 Gene

Sources for DPPA2 Gene