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Aliases for DPPA2 Gene

Aliases for DPPA2 Gene

  • Developmental Pluripotency Associated 2 2 3 5
  • Pluripotent Embryonic Stem Cell-Related Gene 1 Protein 3 4
  • Cancer/Testis Antigen 100 2 3
  • PESCRG1 3 4
  • Embryonic Stem Cell (ESC) Associated Transcript 15-2 3
  • Developmental Pluripotency-Associated Protein 2 3
  • ECAT15-2 3
  • CT100 3

External Ids for DPPA2 Gene

Previous GeneCards Identifiers for DPPA2 Gene

  • GC00U909443
  • GC03M110496
  • GC03M109012
  • GC03M106386

Summaries for DPPA2 Gene

GeneCards Summary for DPPA2 Gene

DPPA2 (Developmental Pluripotency Associated 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is DPPA4.

UniProtKB/Swiss-Prot for DPPA2 Gene

  • Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.

Gene Wiki entry for DPPA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA2 Gene

Genomics for DPPA2 Gene

Regulatory Elements for DPPA2 Gene

Enhancers for DPPA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F109316 0.6 ENCODE 0.8 +0.1 99 0.7 GATA3 PKNOX1 TEAD4 KDM1A NFE2 NFE2L2 DPPA2 ENSG00000277635
GH03F109325 0.4 ENCODE 0.4 -9.1 -9075 0.9 POLR2A DPPA4 DPPA2 PIR39830
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPPA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPPA2 Gene

Chromosome:
3
Start:
109,293,788 bp from pter
End:
109,316,535 bp from pter
Size:
22,748 bases
Orientation:
Minus strand

Genomic View for DPPA2 Gene

Genes around DPPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA2 Gene

Proteins for DPPA2 Gene

  • Protein details for DPPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7J5-DPPA2_HUMAN
    Recommended name:
    Developmental pluripotency-associated protein 2
    Protein Accession:
    Q7Z7J5
    Secondary Accessions:
    • Q8WVF0

    Protein attributes for DPPA2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33784 Da
    Quaternary structure:
    • Interacts with DPPA4.

neXtProt entry for DPPA2 Gene

Post-translational modifications for DPPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPPA2 Gene

No data available for DME Specific Peptides for DPPA2 Gene

Domains & Families for DPPA2 Gene

Protein Domains for DPPA2 Gene

Suggested Antigen Peptide Sequences for DPPA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7J5

UniProtKB/Swiss-Prot:

DPPA2_HUMAN :
  • Contains 1 SAP domain.
Domain:
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with DPPA2: view

No data available for Gene Families for DPPA2 Gene

Function for DPPA2 Gene

Molecular function for DPPA2 Gene

UniProtKB/Swiss-Prot Function:
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.

Gene Ontology (GO) - Molecular Function for DPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DPPA2: view
genes like me logo Genes that share phenotypes with DPPA2: view

Animal Models for DPPA2 Gene

MGI Knock Outs for DPPA2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPPA2 Gene

Localization for DPPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPPA2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with DPPA2: view

Pathways & Interactions for DPPA2 Gene

SuperPathways for DPPA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0019827 stem cell population maintenance IEA --
GO:0031060 regulation of histone methylation IEA --
GO:0060484 lung-associated mesenchyme development IEA --
genes like me logo Genes that share ontologies with DPPA2: view

No data available for Pathways by source and SIGNOR curated interactions for DPPA2 Gene

Transcripts for DPPA2 Gene

mRNA/cDNA for DPPA2 Gene

Unigene Clusters for DPPA2 Gene

Developmental pluripotency associated 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA2 Gene

No ASD Table

Relevant External Links for DPPA2 Gene

GeneLoc Exon Structure for
DPPA2
ECgene alternative splicing isoforms for
DPPA2

Expression for DPPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPPA2 Gene

This gene is overexpressed in Testis (x48.8).

Protein differential expression in normal tissues from HIPED for DPPA2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPPA2 Gene



Protein tissue co-expression partners for DPPA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DPPA2 Gene:

DPPA2

SOURCE GeneReport for Unigene cluster for DPPA2 Gene:

Hs.351113

mRNA Expression by UniProt/SwissProt for DPPA2 Gene:

Q7Z7J5-DPPA2_HUMAN
Tissue specificity: Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues.
genes like me logo Genes that share expression patterns with DPPA2: view

Primer Products

Orthologs for DPPA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPPA2 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia DPPA2 34 35
  • 74.44 (n)
-- 35
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC683282 34
  • 66.1 (n)
mouse
(Mus musculus)
Mammalia Dppa2 34 16 35
  • 60.45 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 59 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 34 (a)
OneToMany
Species where no ortholog for DPPA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA2 Gene

ENSEMBL:
Gene Tree for DPPA2 (if available)
TreeFam:
Gene Tree for DPPA2 (if available)

Paralogs for DPPA2 Gene

Paralogs for DPPA2 Gene

(1) SIMAP similar genes for DPPA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPPA2: view

Variants for DPPA2 Gene

Sequence variations from dbSNP and Humsavar for DPPA2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10154888 -- 109,295,657(+) CAAAT(A/G)GCATA intron-variant
rs10575889 -- 109,300,738(+) AATTG(-/TTTG)AGTAT intron-variant
rs10933982 -- 109,312,068(+) CCAGG(C/T)GTGGT intron-variant
rs10933983 -- 109,317,938(+) aaatc(A/T)ttatt upstream-variant-2KB
rs111348632 -- 109,316,965(+) AATCC(C/G)AGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPPA2 Gene

Variant ID Type Subtype PubMed ID
nsv967049 CNV duplication 23825009
nsv829665 CNV gain 17160897
nsv1117350 CNV tandem duplication 24896259
nsv1002080 CNV loss 25217958
nsv1001807 CNV gain 25217958
dgv4836n100 CNV gain 25217958

Variation tolerance for DPPA2 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPPA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPPA2 Gene

Disorders for DPPA2 Gene

Relevant External Links for DPPA2

Genetic Association Database (GAD)
DPPA2
Human Genome Epidemiology (HuGE) Navigator
DPPA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPPA2

No disorders were found for DPPA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPPA2 Gene

Publications for DPPA2 Gene

  1. Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell. (PMID: 15583978) Du J. … Lu G.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 64
  5. DPPA2 Protein Expression is Associated with Gastric Cancer Metastasis. (PMID: 26745102) Shabestarian H. … Forghanifard M.M. (Asian Pac. J. Cancer Prev. 2015) 3 64

Products for DPPA2 Gene

Sources for DPPA2 Gene

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