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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPPA2 Gene

protein-coding   GIFtS: 50
GCID: GC03M109012

developmental pluripotency associated 2

 Explore 3 diseases affiliated with
DPPA2 via our new
 Human Malady Compendium 
Biological research products
for DPPA2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Developmental Pluripotency Associated 21 2     ECAT15-22
PESCRG11 2 3     Cancer/Testis Antigen 1002
CT1001 2     Developmental Pluripotency-Associated Protein 22
Pluripotent Embryonic Stem Cell-Related Gene 1 Protein2 3     Embryonic Stem Cell (ESC) Associated Transcript 15-22

External Ids:    HGNC: 191971   Entrez Gene: 1518712   Ensembl: ENSG000001635307   OMIM: 6144455   UniProtKB: Q7Z7J53   

Export aliases for DPPA2 gene to outside databases

Previous GC identifers: GC00U909443 GC03M110496 GC03M106386


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5
Function: Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the
maintenance of the active epigenetic status of these genes (By similarity)

Gene Wiki entry for DPPA2 (Developmental pluripotency associated 2)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPPA2 gene promoter:
         COUP-TF1   Elk-1   AML1a   COUP   HNF-4alpha2   c-Ets-1   HNF-4alpha1   POU2F1   COUP-TF   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPPA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPPA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.13   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3q13.13

DPPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPPA2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M109012:  view genomic region     (about GC identifiers)

Start:
109,012,635 bp from pter      End:
109,035,364 bp from pter
Size:
22,730 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5 (See protein sequence)
Recommended Name: Developmental pluripotency-associated protein 2  
Size: 298 amino acids; 33784 Da
Subunit: Interacts with DPPA4 (By similarity)
Subcellular location: Nucleus
Secondary accessions: Q8WVF0

Explore the universe of human proteins at neXtProt for DPPA2: NX_Q7Z7J5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z7J5

  • DPPA2 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_620170.3  
    ENSEMBL proteins: 
     ENSP00000417710  

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    Uscn Proteins for DPPA2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--


    DPPA2 for ontologies           About GeneDecksing



    DPPA2 Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DPPA2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR025892 Dppa2/4_central_dom
     IPR003034 SAP_dom
     IPR025891 Dppa2/4_C_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z7J5

    ProtoNet protein and cluster: Q7Z7J5

    1 Blocks protein family: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5
    Similarity: Contains 1 SAP domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5
    Function: Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the
    maintenance of the active epigenetic status of these genes (By similarity)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003682chromatin binding IEA--


    DPPA2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Dppa2tm1.1Yam for DPPA2
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dppa2):
     cellular  growth/size  homeostasis/metabolism  mortality/aging  normal 
     reproductive system  respiratory system 

    DPPA2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPPA2

    5/21 Interacting proteins for DPPA2 (Q7Z7J52, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP2M1Q96CW12, 3MINT-67494 I2D: score=4 
    DPPA4Q7L1902, 3MINT-67879 I2D: score=4 
    DVL2O146412, 3MINT-66381 I2D: score=4 
    FXR2P511162, 3MINT-68237 I2D: score=4 
    MCM10Q7L5902, 3MINT-67719 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0019827stem cell maintenance IEA--
    GO:0031060regulation of histone methylation IEA--
    GO:0060484lung-associated mesenchyme development IEA--


    DPPA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPPA2
    Search CenterWatch for drugs/clinical trials and news about DPPA2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPPA2 gene: 
    NM_138815.3  

    Unigene Cluster for DPPA2:

    Developmental pluripotency associated 2
    Hs.351113  [show with all ESTs]
    Unigene Representative Sequence: AY283672
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000478945(uc003dxo.3)

    miRNA
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    hsa-miR-877* hsa-miR-1289
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    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPPA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPPA2

    Additional cDNA sequence: 

    AY283672.1 BC018070.1 

    1 DOTS entry:

    DT.91675981 

    24/87 AceView cDNA sequences (see all 87):

    BX115701 AI650955 AA495991 AA682843 AI656779 AU123850 BF223616 BX956395 
    AI992076 AW291865 BC018070 AA219276 AU130753 BX956210 AA226938 BX281871 
    AU135671 AI342042 NM_018189 AA219711 AA461233 AI656896 AA223665 CD048772 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPPA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCTACAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    DPPA2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 253G1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line hIPS1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line hIPS2 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)

    Genevestigator expression for DPPA2

    SOURCE GeneReport for Unigene cluster: Hs.351113

    UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5
    Tissue specificity: Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem
    cells, embryonic fibrocytes and adult tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for DPPA2 (if available)
    TreeFam Gene Tree for DPPA2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPPA2 gene
    DPPA42  
    1 SIMAP similar gene for DPPA2 using alignment to 1 protein entry:     DPPA2_HUMAN:
    DPPA4

    DPPA2 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for DPPA2 (see all 7)
    PGOHUM00000249145 PGOHUM00000243942 PGOHUM00000244847 PGOHUM00000237905 PGOHUM00000245600


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/527 NCBI SNPs in DPPA2 are shown (see all 527    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357672261,2
    C--106392468(+) TACCA-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs1907864691,2
    --109012180(+) CTGAAG/TGGCTC 1 -- int10--------
    rs1473655921,2
    --109012193(+) TTTTCA/GAGTTC 1 -- int10--------
    rs1826365521,2
    --109012263(+) TAGTAC/TTGCTT 1 -- int10--------
    rs1484078561,2
    --109012328(+) AGTATC/TAGTCT 1 -- int10--------
    rs1881306851,2
    --109012409(+) GCCCCA/TGGCAC 1 -- int10--------
    rs753366521,2
    --109012442(+) GACCAA/TTTTTC 1 -- int10--------
    rs1929067061,2
    --109012488(+) ACCCAC/TTTACT 1 -- int10--------
    rs2002375421,2
    --109012576(+) CCAAC-/CACAGTC 1 -- int10--------
    rs1829798641,2
    --109012627(+) CACACC/TGAATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DPPA2 (109012635 - 109035364 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DPPA2: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DPPA2 for disorders           About GeneDecksing

    OMIM gene information: 614445    OMIM disorders: --

    3 diseases for DPPA2:    About MalaCards
    epithelial ovarian cancer    ovarian cancer    lung cancer

    Human Genome Epidemiology (HuGE) Navigator: DPPA2 (1 document)

    Export disorders for DPPA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPPA2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DPPA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell. (PubMed id 15583978)1, 2, 3 Du J.... Lu G.X. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    4. Essential roles of ECAT15-2/Dppa2 in functional lung development. (PubMed id 21896782)1 Nakamura T....Yamanaka S. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Expression and serum immunoreactivity of developmenta lly restricted differentiation antigens in epithelial ovarian cancer. (PubMed id 19705800)1 Tchabo N.E....Odunsi K. (2009)
    7. Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development. (PubMed id 18467432)1 Monk M....Hawes S. (2008)
    8. ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. (PubMed id 18519755)1 John T....Cebon J.S. (2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 151871 HGNC: 19197 AceView: DPPA4 Ensembl:ENSG00000163530 euGenes: HUgn151871
    ECgene: DPPA2 H-InvDB: DPPA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPPA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPPA2 gene:
    Search GeneIP for patents involving DPPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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