DPPA2 Gene
protein-coding GIFtS : 50
GCID: GC03 M109012
developmental pluripotency associated 2
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Aliasesfor DPPA2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Developmental Pluripotency Associated 2 1 2 ECAT15-22 PESCRG11 2 3 Cancer/Testis Antigen 1002 CT1001 2 Developmental Pluripotency-Associated Protein 22 Pluripotent Embryonic Stem Cell-Related Gene 1 Protein2 3 Embryonic Stem Cell (ESC) Associated Transcript 15-22
Export aliases for DPPA2 gene to outside databases Previous GC identifers: GC00U909443 GC03M110496 GC03M106386
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Summariesfor DPPA2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5 Function : Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in themaintenance of the active epigenetic status of these genes (By similarity) Gene Wiki entry for DPPA2 (Developmental pluripotency associated 2)
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Genomic Viewsfor DPPA2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_005612.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DPPA2 gene promoter: COUP-TF1 Elk-1 AML1a COUP HNF-4alpha2 c-Ets-1 HNF-4alpha1 POU2F1 COUP-TF POU2F1a Other transcription factors Search SABiosciences Chromatin IP Primers for DPPA2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPPA2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q13.13 Ensembl cytogenetic band: 3q13.13 HGNC cytogenetic band: 3q13.13 DPPA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M109012: view genomic region
(about GC identifiers )
Start:
109,012,635 bp from pter
End:
109,035,364 bp from pter
Size:
22,730 bases
Orientation:
minus strand
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Proteinsfor DPPA2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5 (See
protein sequence )Recommended Name: Developmental pluripotency-associated protein 2 Size : 298 amino acids; 33784 Da
Subunit : Interacts with DPPA4 (By similarity)
Subcellular location : Nucleus
Secondary accessions : Q8WVF0Explore the universe of human proteins at neXtProt for DPPA2: NX_Q7Z7J5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7Z7J5 DPPA2 Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_620170.3 ENSEMBL proteins: ENSP00000417710 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IDA --
DPPA2 for ontologies About GeneDecksing DPPA2 Antibody Products: Assay Products for DPPA2:
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Protein
Domains / Familiesfor DPPA2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DPPA2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q7Z7J5 ProtoNet protein and cluster: Q7Z7J5
1 Blocks protein family : IPB003034 DNA-binding SAP UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5 Similarity : Contains 1 SAP domain
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Functionfor DPPA2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5 Function : Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in themaintenance of the active epigenetic status of these genes (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DPPA2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DPPA2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DPPA2 (NM_138815 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPPA2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DPPA2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0003682 chromatin binding
IEA --
DPPA2 for ontologies About GeneDecksing Animal Models: Mouse knock-out Dppa2 tm1.1Yam for DPPA2 7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Dppa2) :
DPPA2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor DPPA2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPPA2 5/21 Interacting proteins for DPPA2 (Q7Z7J5 2 , 3 ) via UniProtKB, MINT, STRING, and/or I2D (see all 21 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0019827 stem cell maintenance
IEA -- GO:0031060 regulation of histone methylation
IEA -- GO:0060484 lung-associated mesenchyme development
IEA --
DPPA2 for ontologies About GeneDecksing
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Drugs & Compoundsfor DPPA2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DPPA2 Search CenterWatch for drugs/clinical trials and news about DPPA2
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Transcriptsfor DPPA2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DPPA2 gene: NM_138815.3 Unigene Cluster for DPPA2:
Developmental pluripotency associated 2 Hs.351113 [show with all ESTs ] Unigene Representative Sequence: AY283672 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000478945 (uc003dxo.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DPPA2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DPPA2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DPPA2 (NM_138815 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPPA2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DPPA2
Additional cDNA sequence: AY283672.1 BC018070.1
1 DOTS entry : DT.91675981
24/87 AceView cDNA sequences (see all 87 ):
BX115701 AI650955 AA495991 AA682843 AI656779 AU123850 BF223616 BX956395 AI992076 AW291865 BC018070 AA219276 AU130753 BX956210 AA226938 BX281871 AU135671 AI342042 NM_018189 AA219711 AA461233 AI656896 AA223665 CD048772 GeneLoc Exon Structure
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Expression for DPPA2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DPPA2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATCTACAAAA
About this image DPPA2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Genevestigator expression for DPPA2 SOURCE GeneReport for Unigene cluster: Hs.351113 UniProtKB/Swiss-Prot: DPPA2_HUMAN, Q7Z7J5 Tissue specificity : Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stemcells, embryonic fibrocytes and adult tissues SABiosciences Custom PCR Arrays for DPPA2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DPPA2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DPPA2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DPPA2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DPPA2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA2
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Orthologsfor DPPA2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for DPPA2 (if available)TreeFam Gene Tree for DPPA2 (if available)
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Paralogsfor DPPA2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DPPA2 gene DPPA4 2 1 SIMAP similar gene for DPPA2 using alignment to 1 protein entry: DPPA2_HUMAN :DPPA4
DPPA2 for paralogs About GeneDecksing 5/7 Pseudogenes.org Pseudogenes for DPPA2 (see all 7 )PGOHUM00000249145 PGOHUM00000243942 PGOHUM00000244847 PGOHUM00000237905 PGOHUM00000245600
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Genomic Variantsfor DPPA2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DPPA2 (109012635 - 109035364 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DPPA2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DPPA2
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Disorders
/ Diseasesfor DPPA2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DPPA2 for disorders About GeneDecksing
OMIM gene information: 614445
OMIM disorders : --3 diseases for DPPA2 : About MalaCards epithelial ovarian cancer ovarian cancer lung cancer Human Genome Epidemiology (HuGE) Navigator: DPPA2 (1 document)Export disorders for DPPA2 gene to outside databases
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Publicationsfor DPPA2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DPPA2 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with DPPA2) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell. (PubMed id 15583978) 1 , 2 , 3 Du J.... Lu G.X. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092) 1 Shamay M....Hayward S.D. (2012) Essential roles of ECAT15-2/Dppa2 in functional lung development. (PubMed id 21896782) 1 Nakamura T....Yamanaka S. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Expression and serum immunoreactivity of developmenta lly restricted differentiation antigens in epithelial ovarian cancer. (PubMed id 19705800) 1 Tchabo N.E....Odunsi K. (2009) Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development. (PubMed id 18467432) 1 Monk M....Hawes S. (2008) ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. (PubMed id 18519755) 1 John T....Cebon J.S. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005)
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External Searches for DPPA2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DPPA2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DPPA2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DPPA2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DPPA2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DPPA2 gene: Search GeneIP for patents involving DPPA2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DPPA2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for DPPA2 OriGene shRNA RFP for DPPA2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DPPA2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DPPA2 OriGene Protein Over-expression Lysate for DPPA2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DPPA2 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DPPA2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DPPA2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DPPA2 OriGene Custom Protein Services for DPPA2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPPA2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DPPA2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPPA2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DPPA2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DPPA2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DPPA2
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DPPA2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPPA2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DPPA2
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Aliases for DPPA2
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Disorders / Diseases for DPPA2
Domains / Families for DPPA2
Drugs / Compounds for DPPA2
Expression for DPPA2
Function for DPPA2
Genomic Views for DPPA2
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Orthologs for DPPA2
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Pathways / Interactions for DPPA2
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Proteins for DPPA2
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Transcripts for DPPA2
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