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Aliases for DPP9 Gene

Aliases for DPP9 Gene

  • Dipeptidyl-Peptidase 9 2 3
  • Dipeptidyl Peptidase IV-Related Protein 2 3 4
  • Dipeptidyl Peptidase-Like Protein 9 3 4
  • Dipeptidyl Peptidase IX 3 4
  • Dipeptidylpeptidase 9 2 3
  • DPP IX 3 4
  • DPRP-2 3 4
  • DPLP9 3 4
  • DPRP2 3 4
  • DP9 3 4
  • Dipeptidyl Peptidase IV-Related Protein-2 3
  • Dipeptidyl Peptidase 9 3
  • EC 3.4.14.5 4

External Ids for DPP9 Gene

Summaries for DPP9 Gene

Entrez Gene Summary for DPP9 Gene

  • This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP9 Gene

DPP9 (Dipeptidyl-Peptidase 9) is a Protein Coding gene. Diseases associated with DPP9 include pulmonary fibrosis, idiopathic and obesity. GO annotations related to this gene include identical protein binding and aminopeptidase activity. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot for DPP9 Gene

  • Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2

Gene Wiki entry for DPP9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP9 Gene

Genomics for DPP9 Gene

Genomic Location for DPP9 Gene

Start:
4,675,224 bp from pter
End:
4,724,673 bp from pter
Size:
49,450 bases
Orientation:
Minus strand

Genomic View for DPP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP9 Gene

Regulatory Elements for DPP9 Gene

Proteins for DPP9 Gene

  • Protein details for DPP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TI2-DPP9_HUMAN
    Recommended name:
    Dipeptidyl peptidase 9
    Protein Accession:
    Q86TI2
    Secondary Accessions:
    • O75273
    • O75868
    • Q1ZZB8
    • Q6AI37
    • Q6UAL0
    • Q6ZMT2
    • Q6ZNJ5
    • Q8N2J7
    • Q8N3F5
    • Q8WXD8
    • Q96NT8
    • Q9BVR3

    Protein attributes for DPP9 Gene

    Size:
    863 amino acids
    Molecular mass:
    98263 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC33801.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC62840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH37948.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL47179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO73880.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB70784.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85150.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAD18643.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAD39039.3; Type=Frameshift; Positions=432, 460; Evidence={ECO:0000305};

    Alternative splice isoforms for DPP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPP9 Gene

Proteomics data for DPP9 Gene at MOPED

Post-translational modifications for DPP9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys828

No data available for DME Specific Peptides for DPP9 Gene

Domains for DPP9 Gene

Protein Domains for DPP9 Gene

Graphical View of Domain Structure for InterPro Entry

Q86TI2

UniProtKB/Swiss-Prot:

DPP9_HUMAN
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.:
    • Q86TI2
genes like me logo Genes that share domains with DPP9: view

No data available for Gene Families for DPP9 Gene

Function for DPP9 Gene

Molecular function for DPP9 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=161 uM for Ala-Pro-AMC {ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15245913}; KM=180 uM for Ala-Pro-AFC {ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15245913}; pH dependence: Optimum pH is 7.5-8.5. Little activity below pH 6.5. {ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15245913};
UniProtKB/Swiss-Prot CatalyticActivity: Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate.
UniProtKB/Swiss-Prot Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2

Enzyme Numbers (IUBMB) for DPP9 Gene

Gene Ontology (GO) - Molecular Function for DPP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity --
GO:0042802 identical protein binding IPI 22001206
genes like me logo Genes that share ontologies with DPP9: view

miRNA for DPP9 Gene

miRTarBase miRNAs that target DPP9

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPP9 Gene

Localization for DPP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP9 Gene

Isoform 1: Cytoplasm, cytosol.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPP9 Gene COMPARTMENTS Subcellular localization image for DPP9 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DPP9: view

Pathways for DPP9 Gene

SuperPathways for DPP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DPP9: view

No data available for Pathways by source for DPP9 Gene

Compounds for DPP9 Gene

(3) Novoseek inferred chemical compound relationships for DPP9 Gene

Compound -log(P) Hits PubMed IDs
dpps 90 1
serine 42.3 3
proline 41.3 2
genes like me logo Genes that share compounds with DPP9: view

Transcripts for DPP9 Gene

Unigene Clusters for DPP9 Gene

Dipeptidyl-peptidase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPP9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d · 12e ·
SP1: - - - - - - - - -
SP2:
SP3:
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10:
SP11: - - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15:
SP16: - - - - - - -
SP17: -
SP18: - - - -

ExUns: 12f · 12g ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a ·
SP1: - - -
SP2: -
SP3:
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - -
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

ExUns: 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DPP9 Gene

GeneLoc Exon Structure for
DPP9
ECgene alternative splicing isoforms for
DPP9

Expression for DPP9 Gene

mRNA expression in normal human tissues for DPP9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPP9 Gene

SOURCE GeneReport for Unigene cluster for DPP9 Gene Hs.515081

mRNA Expression by UniProt/SwissProt for DPP9 Gene

Q86TI2-DPP9_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.
genes like me logo Genes that share expressions with DPP9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DPP9 Gene

Orthologs for DPP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP9 35
  • 99.48 (n)
  • 99.55 (a)
DPP9 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPP9 35
  • 88.63 (n)
  • 93.15 (a)
DPP9 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPP9 35
  • 90.01 (n)
  • 94.05 (a)
DPP9 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp9 35
  • 84.94 (n)
  • 93.58 (a)
Dpp9 16
Dpp9 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP9 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPP9 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpp9 35
  • 82.41 (n)
  • 89.76 (a)
chicken
(Gallus gallus)
Aves DPP9 35
  • 77.19 (n)
  • 87.3 (a)
DPP9 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP9 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5231 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp9 35
  • 68.18 (n)
  • 75.81 (a)
zebrafish
(Danio rerio)
Actinopterygii dpp9 35
  • 71.91 (n)
  • 79.07 (a)
dpp9 36
  • 80 (a)
OneToOne
Dr.11668 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003138 35
  • 55.41 (n)
  • 45.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3744 35
  • 52.32 (n)
  • 44.64 (a)
CG3744 36
  • 33 (a)
OneToMany
CG3744 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea K02F2.1b 37
  • 32 (a)
K02F2.1a 37
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G24260 35
  • 43.87 (n)
  • 35.11 (a)
rice
(Oryza sativa)
Liliopsida Os02g0290600 35
  • 42.97 (n)
  • 35.27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4146 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for DPP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP9 Gene

ENSEMBL:
Gene Tree for DPP9 (if available)
TreeFam:
Gene Tree for DPP9 (if available)

Paralogs for DPP9 Gene

Paralogs for DPP9 Gene

genes like me logo Genes that share paralogs with DPP9: view

Variants for DPP9 Gene

Sequence variations from dbSNP and Humsavar for DPP9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs732631 -- 4,719,013(+) TAGGG(C/G)ACTTC intron-variant
rs758508 -- 4,718,690(+) CAGAT(C/T)CCCTT intron-variant
rs758509 -- 4,719,005(+) CCTGA(C/T)TTTAG intron-variant
rs758510 -- 4,721,979(+) TTCCA(C/G)TTCCC intron-variant
rs887277 -- 4,719,009(+) ATTTT(A/G)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP9 Gene

Variant ID Type Subtype PubMed ID
dgv3678n71 CNV Loss 21882294
nsv428361 CNV Loss 18775914
nsv910847 CNV Loss 21882294
nsv910848 CNV Loss 21882294
nsv910849 CNV Loss 21882294
dgv3680n71 CNV Loss 21882294
dgv3681n71 CNV Loss 21882294
nsv910856 CNV Loss 21882294
nsv833721 CNV Loss 17160897
esv2666899 CNV Deletion 23128226
esv26771 CNV Loss 19812545

Relevant External Links for DPP9 Gene

HapMap Linkage Disequilibrium report
DPP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP9 Gene

Disorders for DPP9 Gene

Relevant External Links for DPP9

Genetic Association Database (GAD)
DPP9
Human Genome Epidemiology (HuGE) Navigator
DPP9
genes like me logo Genes that share disorders with DPP9: view

No data available for UniProtKB/Swiss-Prot for DPP9 Gene

Publications for DPP9 Gene

  1. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. (PMID: 12459266) Olsen C. … Wagtmann N. (Gene 2002) 3 4 23
  2. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PMID: 12662155) Qi S.Y. … Akinsanya K.O. (Biochem. J. 2003) 3 4 23
  3. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. (PMID: 15245913) Ajami K. … Gorrell M.D. (Biochim. Biophys. Acta 2004) 3 4 23
  4. Association study between adolescent idiopathic scoliosis and the DPP9 gene which is located in the candidate region identified by linkage analysis. (PMID: 18940951) Qiu X.S. … Cheng J.C. (Postgrad Med J 2008) 3 23 48
  5. The in vivo expression of dipeptidyl peptidases 8 and 9. (PMID: 19581630) Yu D.M. … Gorrell M.D. (J. Histochem. Cytochem. 2009) 3 23

Products for DPP9 Gene

Sources for DPP9 Gene

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