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DPP9 Gene

protein-coding   GIFtS: 57
GCID: GC19M004675

Dipeptidyl-Peptidase 9

(Previous name: dipeptidylpeptidase 9)
  See DPP9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dipeptidyl-Peptidase 91 2     DPRP-22 3
Dipeptidylpeptidase 91 2     DPRP22 3
Dipeptidyl Peptidase IV-Related Protein 22 3     DPP IX2 3
Dipeptidyl Peptidase IX2 3     Dipeptidyl Peptidase 92
Dipeptidyl Peptidase-Like Protein 92 3     Dipeptidyl Peptidase IV-Related Protein-22
DP92 3     EC 3.4.14.53
DPLP92 3     

External Ids:    HGNC: 186481   Entrez Gene: 910392   Ensembl: ENSG000001420027   OMIM: 6082585   UniProtKB: Q86TI23   

Export aliases for DPP9 gene to outside databases

Previous GC identifers: GC19M004768 GC19M004616 GC19M004626 GC19M004435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPP9 Gene:
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has
been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the
N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4),
it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the
regulation of the activity of their substrates and have been linked to a variety of diseases including type 2
diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPP9 Gene:
DPP9 (dipeptidyl-peptidase 9) is a protein-coding gene. Diseases associated with DPP9 include idiopathic pulmonary fibrosis, and obesity. GO annotations related to this gene include aminopeptidase activity and identical protein binding. An important paralog of this gene is DPP8.

UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2
Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at
position 2

Gene Wiki entry for DPP9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPP9 gene promoter:
         HFH-1   FOXD3   Olf-1   HNF-3beta   NF-E2 p45   NF-E2   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DPP9 promoter sequence
   Search Chromatin IP Primers for DPP9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

DPP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004675:  view genomic region     (about GC identifiers)

Start:
4,675,236 bp from pter      End:
4,724,685 bp from pter
Size:
49,450 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 9  
Size: 863 amino acids; 98263 Da
Subunit: Homodimer
Sequence caution: Sequence=AAC33801.1; Type=Erroneous gene model prediction; Sequence=AAC62840.1; Type=Erroneous
gene model prediction; Sequence=AAH37948.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAL47179.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO73880.2;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB70784.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAC11362.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAC85150.1; Type=Miscellaneous discrepancy; Note=Probable
cloning artifact; Sequence=BAD18643.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAD39039.3; Type=Frameshift; Positions=432, 460;
Secondary accessions: O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8
Q96NT8 Q9BVR3
Alternative splicing: 3 isoforms:  Q86TI2-1   Q86TI2-2   Q86TI2-4   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for DPP9: NX_Q86TI2

Explore proteomics data for DPP9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys828
  • Modification sites at PhosphoSitePlus

  • See DPP9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_631898.3  
    ENSEMBL proteins: 
     ENSP00000472224   ENSP00000262960   ENSP00000469187   ENSP00000469603   ENSP00000472968  
     ENSP00000471954   ENSP00000471659   ENSP00000472430   ENSP00000473175   ENSP00000472549  
     ENSP00000470393   ENSP00000473130   ENSP00000471250   ENSP00000469152   ENSP00000471629  
     ENSP00000469020   ENSP00000469282  

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    Cloud-Clone Corp. Proteins for DPP9

     
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    antibodies-online proteins for DPP9 (2 products) 

     
    antibodies-online peptides for DPP9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001375 Peptidase_S9
     IPR002469 Peptidase_S9B

    Graphical View of Domain Structure for InterPro Entry Q86TI2

    ProtoNet protein and cluster: Q86TI2

    1 Blocks protein domain: IPB002469 Dipeptidylpeptidase IV (CD26)

    UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2
    Similarity: Belongs to the peptidase S9B family. DPPIV subfamily


    Find genes that share domains with DPP9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPP9_HUMAN, Q86TI2
    Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at
    position 2
    Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when
    Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
    Enzyme regulation: Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF),
    and by di-isopropylfuorophosphate
    Biophysicochemical properties: Kinetic parameters: KM=161 uM for Ala-Pro-AMC; KM=180 uM for Ala-Pro-AFC; pH
    dependence: Optimum pH is 7.5-8.5. Little activity below pH 6.5;

         Enzyme Number (IUBMB): EC 3.4.14.51

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008236serine-type peptidase activity IEA--
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with DPP9           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Dpp9 (no phenotypes)

    Find genes that share phenotypes with DPP9           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DPP9

    miRNA
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    miRTarBase miRNAs that target DPP9:
    hsa-mir-106b-5p (MIRT020452)

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    hsa-miR-125a-5p hsa-miR-148b hsa-miR-331-3p hsa-miR-944 hsa-miR-340 hsa-miR-218 hsa-miR-125b hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidDPP9 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for DPP9
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPP9_HUMAN, Q86TI2: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with DPP9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPP9
    Interactions:

        GeneGlobe Interaction Network for DPP9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DPP9 (Q86TI21, 3 ENSP000002629604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    DPP9Q86TI21EBI-7475352,EBI-7475352
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with DPP9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPP9

    3 Novoseek inferred chemical compound relationships for DPP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 90 1 17328877 (1)
    serine 42.3 4 12459266 (1), 16704418 (1), 17223229 (1)
    proline 41.3 2 14687920 (1), 12941425 (1)



    Find genes that share compounds with DPP9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPP9 gene: 
    NM_139159.4  

    Unigene Cluster for DPP9:

    Dipeptidyl-peptidase 9
    Hs.515081  [show with all ESTs]
    Unigene Representative Sequence: AF452102
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000594671 ENST00000262960(uc002mba.3) ENST00000597145 ENST00000601720
    ENST00000598800 ENST00000597900 ENST00000601173 ENST00000595327 ENST00000597253
    ENST00000599998 ENST00000599163 ENST00000597849 ENST00000601764 ENST00000597726
    ENST00000600621 ENST00000600556 ENST00000602161 ENST00000598360
    miRNA
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    hsa-miR-125a-5p hsa-miR-148b hsa-miR-331-3p hsa-miR-944 hsa-miR-340 hsa-miR-218 hsa-miR-125b hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidDPP9 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPP9
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      QuantiFast Probe-based Assays in human, mouse, rat DPP9

    Additional mRNA sequence: 

    AF452102.2 AF542510.2 AK075030.1 AK122645.1 AK122654.1 AK131100.1 AK131499.1 AL834376.1 
    AY172660.1 AY374518.1 BC000970.1 BC017008.1 BC037948.2 CR627380.1 DQ417928.1 

    22 DOTS entries:

    DT.95199882  DT.40217262  DT.95199874  DT.92423656  DT.97762790  DT.121426479  DT.100676257  DT.100713849 
    DT.95199824  DT.100814090  DT.121426530  DT.95199872  DT.100742986  DT.100814085  DT.121426482  DT.121426488 
    DT.121426510  DT.121426512  DT.121426531  DT.40275912  DT.95199818  DT.91967715 

    Selected AceView cDNA sequences (see all 273):

    BQ691369 AI220560 BU617501 BQ685108 BX443745 BM424091 BU169368 BM560972 
    BG108176 BF897130 CR604042 AK075030 BU157739 NM_139159 BF892536 BM011575 
    BU173712 BP364775 AA708616 BQ681307 AA659692 BQ877810 BQ949519 AF452102 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DPP9 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d · 12e ·
    SP1:                                            -     -           -                       -     -     -     -     -     -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                            -     -           -                       -     -     -     -     -     -           -     -     -     -     -   
    SP5:                                            -     -                                   -     -     -     -     -     -                                       

    ExUns: 12f · 12g ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a ·
    SP1:                                                                                                              -                       -                 -   
    SP2:                                                                                            -                                                               
    SP3:                                                                                                                                                            
    SP4:  -     -     -     -     -     -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DPP9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTGCCTG
    DPP9 Expression
    About this image

    DPP9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPP9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515081

    UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2
    Tissue specificity: Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in
    brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPP9 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpp91 , 5 dipeptidylpeptidase 91, 5 84.94(n)1
    93.58(a)1
      17 (29.20 cM)5
    2248971  NM_172624.31  NP_766212.21 
     561866825 
    chicken
    (Gallus gallus)
    Aves DPP91 dipeptidyl-peptidase 9 77.19(n)
    87.3(a)
      420159  XM_418272.4  XP_418272.3 
    lizard
    (Anolis carolinensis)
    Reptilia DPP96
    dipeptidyl-peptidase 9
    80(a)
    1 ↔ 1
    GL344400.1(17273-39078)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52312 Xenopus laevis transcribed sequence with weak similarity more 70.59(n)    BU907445.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.116682 Transcribed sequence with weak similarity to protein more 78.08(n)    AW153759.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37441 , 3 Xaa-Pro dipeptidyl-peptidase3
    CG37441
    39(a)3
    52.32(n)1
    44.64(a)1
      96B23
    429721  NM_001276006.11  NP_001262935.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G242601 AT5G24260 43.87(n)
    35.11(a)
      832493  NM_122332.3  NP_197814.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02906001 Os02g0290600 42.97(n)
    35.27(a)
      4329059  NM_001053127.1  NP_001046592.1 


    ENSEMBL Gene Tree for DPP9 (if available)
    TreeFam Gene Tree for DPP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPP9 gene
    DPP82  FAP2  DPP102  DPP62  DPP42  
    Selected SIMAP similar genes for DPP9 using alignment to 15 protein entries:     DPP9_HUMAN (see all proteins) (see all similar genes):
    ZNF554    ZNF546    SH2B3    ATL2    DUSP3    NDUFS3
    SUV420H1    TUBA1C    ZNF114    FLJ00047    SMYD4    TNNT1
    LDLRAD3    BIRC3    CSPP1    DYNC2LI1    LSM12    SLMO1

    Find genes that share paralogs with DPP9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPP9 (see all 952)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116705701,2
    C,F,A,H--4674799(+) GTTGCA/GAACAG 1 -- ds500133Minor allele frequency- G:0.29NS EA NA WA CSA 3550
    rs116664401,2
    C,F,H--4674833(+) TGGGAC/TGATGT 1 -- ds50012Minor allele frequency- T:0.18NA 124
    rs1426782391,2
    --4675087(+) GTGGGA/TCAGTC 1 -- ds50010--------
    rs1822186541,2
    --4675153(+) CAGTGC/TCCTTC 1 -- ds50010--------
    rs729779601,2
    C,F--4675179(+) GTTGCC/ACCCCG 1 -- ds50011Minor allele frequency- A:0.17NA 120
    rs1460412261,2
    --4675262(+) CGTTTA/GATGTG 1 -- ut310--------
    rs729779611,2
    --4675347(+) GGTTTG/TTTTCT 1 -- ut310--------
    rs2016250811,2
    C--4675533(-) TCCCCC/TCCCCA 1 -- ut310--------
    rs1873841291,2
    --4675587(+) AGTGCA/CTGCCT 1 -- ut310--------
    rs1902265531,2
    --4675761(+) ATTTAA/GGCACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DPP9 (4675236 - 4724685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DPP9 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666899CNV Deletion23128226
    nsv910847CNV Loss21882294
    nsv428361CNV Loss18775914
    dgv3681n71CNV Loss21882294
    esv26771CNV Loss19812545
    dgv3680n71CNV Loss21882294
    nsv833721CNV Loss17160897
    dgv3678n71CNV Loss21882294
    nsv910849CNV Loss21882294
    nsv910856CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPP9
    DNA2.0 Custom Variant and Variant Library Synthesis for DPP9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608258    OMIM disorders: --

    2 diseases for DPP9:    
    About MalaCards
    idiopathic pulmonary fibrosis    obesity


    Find genes that share disorders with DPP9           About GenesLikeMe

    Genetic Association Database (GAD): DPP9
    Human Genome Epidemiology (HuGE) Navigator: DPP9 (1 document)

    Export disorders for DPP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPP9 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with DPP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. (PubMed id 12459266)1, 2, 9 Olsen C. and Wagtmann N. (Gene 2002)
    2. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. (PubMed id 15245913)1, 2, 9 Ajami K.... Gorrell M.D. (Biochim. Biophys. Acta 2004)
    3. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PubMed id 12662155)1, 2, 9 Qi S.Y.... Akinsanya K.O. (Biochem. J. 2003)
    4. Association study between adolescent idiopathic scoliosis and the DPP9 gene which is located in the candidate region identified by linkage analysis. (PubMed id 18940951)1, 4, 9 Qiu X.S....Cheng J.C. (Postgrad Med J 2008)
    5. Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV. (PubMed id 16475979)1, 2 Bjelke J.R.... Rasmussen H.B. (Biochem. J. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. (PubMed id 16704418)1, 9 Yu D.M....Gorrell M.D. (FEBS J. 2006)
    9. The in vivo expression of dipeptidyl peptidases 8 and 9. (PubMed id 19581630)1, 9 Yu D.M....Gorrell M.D. (J. Histochem. Cytochem. 2009)
    10. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. (PubMed id 24072711)1 Pilla E....Geiss-Friedlander R. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91039 HGNC: 18648 AceView: DPP9 Ensembl:ENSG00000142002 euGenes: HUgn91039
    ECgene: DPP9 H-InvDB: DPP9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DPP9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DPP9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPP9 gene:
    Search GeneIP for patents involving DPP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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