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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPP9 Gene

protein-coding   GIFtS: 56
GCID: GC19M004675

Dipeptidyl-Peptidase 9

(Previous name: dipeptidylpeptidase 9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dipeptidyl-Peptidase 91 2     DPRP-22 3
Dipeptidylpeptidase 91 2     DPRP22 3
Dipeptidyl Peptidase IV-Related Protein 22 3     DPP IX2 3
Dipeptidyl Peptidase IX2 3     Dipeptidyl Peptidase 92
Dipeptidyl Peptidase-Like Protein 92 3     Dipeptidyl Peptidase IV-Related Protein-22
DP92 3     EC 3.4.14.53
DPLP92 3     

External Ids:    HGNC: 186481   Entrez Gene: 910392   Ensembl: ENSG000001420027   OMIM: 6082585   UniProtKB: Q86TI23   

Export aliases for DPP9 gene to outside databases

Previous GC identifers: GC19M004768 GC19M004616 GC19M004626 GC19M004435


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPP9 Gene:
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has
been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the
N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4),
it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the
regulation of the activity of their substrates and have been linked to a variety of diseases including type 2
diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPP9 Gene: 
DPP9 (dipeptidyl-peptidase 9) is a protein-coding gene. Diseases associated with DPP9 include scoliosis, and obesity. GO annotations related to this gene include serine-type peptidase activity and aminopeptidase activity. An important paralog of this gene is DPP8.

UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2
Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at
position 2

Gene Wiki entry for DPP9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPP9 gene promoter:
         HFH-1   FOXD3   Olf-1   HNF-3beta   NF-E2 p45   NF-E2   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DPP9 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPP9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

DPP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004675:  view genomic region     (about GC identifiers)

Start:
4,675,236 bp from pter      End:
4,724,685 bp from pter
Size:
49,450 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 9  
Size: 863 amino acids; 98263 Da
Subunit: Homodimer
Subcellular location: Cytoplasm, cytosol
Sequence caution: Sequence=AAC33801.1; Type=Erroneous gene model prediction; Sequence=AAC62840.1; Type=Erroneous
gene model prediction; Sequence=AAH37948.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAL47179.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO73880.2;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB70784.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAC11362.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAC85150.1; Type=Miscellaneous discrepancy; Note=Probable
cloning artifact; Sequence=BAD18643.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAD39039.3; Type=Frameshift; Positions=432, 460;
Secondary accessions: O75273 O75868 Q1ZZB8 Q6AI37 Q6UAL0 Q6ZMT2 Q6ZNJ5 Q8N2J7 Q8N3F5 Q8WXD8
Q96NT8 Q9BVR3
Alternative splicing: 3 isoforms:  Q86TI2-1   Q86TI2-2   Q86TI2-4   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for DPP9: NX_Q86TI2

Explore proteomics data for DPP9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TI2

  • DPP9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPP9 Protein Expression
    REFSEQ proteins: NP_631898.3  
    ENSEMBL proteins: 
     ENSP00000472224   ENSP00000262960   ENSP00000469187   ENSP00000469603   ENSP00000472968  
     ENSP00000471954   ENSP00000471659   ENSP00000472430   ENSP00000473175   ENSP00000472549  
     ENSP00000470393   ENSP00000473130   ENSP00000471250   ENSP00000469152   ENSP00000471629  
     ENSP00000469020   ENSP00000469282  

    Human Recombinant Protein Products for DPP9: 
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    Novus Biologicals DPP9 Protein
    Novus Biologicals DPP9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DPP9 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0016020membrane IEA--

    DPP9 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for DPP9 
    Cloud-Clone Corp. CLIAs for DPP9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001375 Peptidase_S9
     IPR002469 Peptidase_S9B

    Graphical View of Domain Structure for InterPro Entry Q86TI2

    ProtoNet protein and cluster: Q86TI2

    1 Blocks protein domain: IPB002469 Dipeptidylpeptidase IV (CD26)

    UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2
    Similarity: Belongs to the peptidase S9B family. DPPIV subfamily


    DPP9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPP9_HUMAN, Q86TI2
    Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at
    position 2
    Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when
    Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
    Enzyme regulation: Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF),
    and by di-isopropylfuorophosphate
    Biophysicochemical properties: Kinetic parameters: KM=161 uM for Ala-Pro-AMC; KM=180 uM for Ala-Pro-AFC; pH
    dependence: Optimum pH is 7.5-8.5. Little activity below pH 6.5;

         Enzyme Number (IUBMB): EC 3.4.14.51

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008236serine-type peptidase activity IEA--
    GO:0042802identical protein binding IPI--
         
    DPP9 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidDPP9 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPP9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DPP9 (Q86TI23 ENSP000002629604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    DPP9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DPP9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPP9

    3 Novoseek inferred chemical compound relationships for DPP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 90 1 17328877 (1)
    serine 42.3 4 12459266 (1), 16704418 (1), 17223229 (1)
    proline 41.3 2 14687920 (1), 12941425 (1)

    Search CenterWatch for drugs/clinical trials and news about DPP9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPP9 gene: 
    NM_139159.4  

    Unigene Cluster for DPP9:

    Dipeptidyl-peptidase 9
    Hs.515081  [show with all ESTs]
    Unigene Representative Sequence: AF452102
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000594671 ENST00000262960(uc002mba.3) ENST00000597145 ENST00000601720
    ENST00000598800 ENST00000597900 ENST00000601173 ENST00000595327 ENST00000597253
    ENST00000599998 ENST00000599163 ENST00000597849 ENST00000601764 ENST00000597726
    ENST00000600621 ENST00000600556 ENST00000602161 ENST00000598360
    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate DPP9 (see all 18):
    hsa-miR-125a-5p hsa-miR-148b hsa-miR-331-3p hsa-miR-944 hsa-miR-340 hsa-miR-218 hsa-miR-125b hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidDPP9 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP9
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP9

    Additional mRNA sequence: 

    AF452102.2 AF542510.2 AK075030.1 AK122645.1 AK122654.1 AK131100.1 AK131499.1 AL834376.1 
    AY172660.1 AY374518.1 BC000970.1 BC017008.1 BC037948.2 CR627380.1 DQ417928.1 

    22 DOTS entries:

    DT.95199882  DT.40217262  DT.95199874  DT.92423656  DT.97762790  DT.121426479  DT.100676257  DT.100713849 
    DT.95199824  DT.100814090  DT.121426530  DT.95199872  DT.100742986  DT.100814085  DT.121426482  DT.121426488 
    DT.121426510  DT.121426512  DT.121426531  DT.40275912  DT.95199818  DT.91967715 

    24/273 AceView cDNA sequences (see all 273):

    BC037948 BQ897707 BI223668 NM_139159 BQ889360 AI660576 AI220560 AF452102 
    BQ688215 BC017008 BU187663 BQ949519 BU157739 AK131499 BX385217 AA877297 
    BX472455 BF897130 BF002308 BM424091 BQ685128 BQ684956 BU173712 BC000970 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for DPP9 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d · 12e ·
    SP1:                                            -     -           -                       -     -     -     -     -     -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                            -     -           -                       -     -     -     -     -     -           -     -     -     -     -   
    SP5:                                            -     -                                   -     -     -     -     -     -                                       

    ExUns: 12f · 12g ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a ·
    SP1:                                                                                                              -                       -                 -   
    SP2:                                                                                            -                                                               
    SP3:                                                                                                                                                            
    SP4:  -     -     -     -     -     -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DPP9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTGCCTG
    DPP9 Expression
    About this image


    See DPP9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPP9

    SOURCE GeneReport for Unigene cluster: Hs.515081

    UniProtKB/Swiss-Prot: DPP9_HUMAN, Q86TI2
    Tissue specificity: Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in
    brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPP9 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpp91 , 5 dipeptidylpeptidase 91, 5 84.38(n)1
    92.21(a)1
      17 (29.20 cM)5
    2248971  NM_172624.31  NP_766212.21 
     561866825 
    chicken
    (Gallus gallus)
    Aves DPP91 dipeptidyl-peptidase 9 77.27(n)
    87.19(a)
      420159  XM_418272.3  XP_418272.3 
    lizard
    (Anolis carolinensis)
    Reptilia DPP96
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL344400.1(17273-39078)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52312 Xenopus laevis transcribed sequence with weak similarity more 70.59(n)    BU907445.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.116682 Transcribed sequence with weak similarity to protein more 78.08(n)    AW153759.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37441 , 3 Xaa-Pro dipeptidyl-peptidase3
    CG37441
    39(a)3
    52.27(n)1
    44.03(a)1
      96B23
    429721  NM_143047.21  NP_651304.21 
    worm
    (Caenorhabditis elegans)
    Secernentea K02F2.1a3
    dpf-31
    peptidase3
    Protein DPF-31
    32(a)
    (best of 2)3
    45.48(n)1
    36.45(a)1
      I(6846420-6851166)3
    1724091  NM_059555.11  NP_491956.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAP26
    STE136
    Dipeptidyl aminopeptidase, synthesized as a glycos...
    Dipeptidyl aminopeptidase, Golgi integral membrane...
    18(a)
    16(a)
    many ↔ many
    many ↔ many
    VIII(164978-167434)
    XV(752214-755009)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G242601 dipeptidyl-peptidase 4 44.26(n)
    35.98(a)
      832493  NM_122332.3  NP_197814.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02906001 hypothetical protein 43.22(n)
    35.88(a)
      4329059  NM_001053127.1  NP_001046592.1 


    ENSEMBL Gene Tree for DPP9 (if available)
    TreeFam Gene Tree for DPP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPP9 gene
    DPP82  FAP2  DPP102  DPP62  DPP42  
    18/85 SIMAP similar genes for DPP9 using alignment to 15 protein entries:     DPP9_HUMAN (see all proteins) (see all similar genes):
    ZNF554    ZNF546    SH2B3    ATL2    DUSP3    LOC100996577
    NDUFS3    SUV420H1    TUBA1C    ZNF114    FLJ00047    SMYD4
    TNNT1    LDLRAD3    BIRC3    CSPP1    DYNC2LI1    LSM12

    DPP9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/952 SNPs in DPP9 are shown (see all 952)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116705701,2
    C,F,A,H--4674799(+) GTTGCA/GAACAG 1 -- ds500133Minor allele frequency- G:0.29NS EA NA WA CSA 3550
    rs116664401,2
    C,F,H--4674833(+) TGGGAC/TGATGT 1 -- ds50012Minor allele frequency- T:0.18NA 124
    rs1426782391,2
    --4675087(+) GTGGGA/TCAGTC 1 -- ds50010--------
    rs1822186541,2
    --4675153(+) CAGTGC/TCCTTC 1 -- ds50010--------
    rs729779601,2
    C,F--4675179(+) GTTGCC/ACCCCG 1 -- ds50011Minor allele frequency- A:0.17NA 120
    rs1460412261,2
    --4675262(+) CGTTTA/GATGTG 1 -- ut310--------
    rs729779611,2
    --4675347(+) GGTTTG/TTTTCT 1 -- ut310--------
    rs2016250811,2
    C--4675533(-) TCCCCC/TCCCCA 1 -- ut310--------
    rs1873841291,2
    --4675587(+) AGTGCA/CTGCCT 1 -- ut310--------
    rs1902265531,2
    --4675761(+) ATTTAA/GGCACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DPP9 (4675236 - 4724685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for DPP9 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666899CNV Deletion23128226
    nsv910847CNV Loss21882294
    nsv428361CNV Loss18775914
    dgv3681n71CNV Loss21882294
    esv26771CNV Loss19812545
    dgv3680n71CNV Loss21882294
    nsv833721CNV Loss17160897
    dgv3678n71CNV Loss21882294
    nsv910849CNV Loss21882294
    nsv910856CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608258    OMIM disorders: --

    8 diseases for DPP9:    About MalaCards
    scoliosis    obesity    b-cell chronic lymphocytic leukemia    fanconi's anemia
    meningioma    chronic lymphocytic leukemia    anemia    leukemia


    DPP9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DPP9
    Human Genome Epidemiology (HuGE) Navigator: DPP9 (1 document)

    Export disorders for DPP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPP9 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with DPP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. (PubMed id 12459266)1, 2, 9 Olsen C. and Wagtmann N. (2002)
    2. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. (PubMed id 15245913)1, 2, 9 Ajami K.... Gorrell M.D. (2004)
    3. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PubMed id 12662155)1, 2, 9 Qi S.Y....Akinsanya K.O. (2003)
    4. Association study between adolescent idiopathic scoliosis and the DPP9 gene which is located in the candidate region identified by linkage analysis. (PubMed id 18940951)1, 4, 9 Qiu X.S....Cheng J.C. (2008)
    5. Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV. (PubMed id 16475979)1, 2 Bjelke J.R.... Rasmussen H.B. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. (PubMed id 16704418)1, 9 Yu D.M....Gorrell M.D. (2006)
    9. The in vivo expression of dipeptidyl peptidases 8 and 9. (PubMed id 19581630)1, 9 Yu D.M....Gorrell M.D. (2009)
    10. Dipeptidyl peptidases in atherosclerosis: expression a nd role in macrophage differentiation, activation and apoptosis. (PubMed id 23608773)1 Matheeussen V....De Meester I. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91039 HGNC: 18648 AceView: DPP9 Ensembl:ENSG00000142002 euGenes: HUgn91039
    ECgene: DPP9 H-InvDB: DPP9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPP9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DPP9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPP9 gene:
    Search GeneIP for patents involving DPP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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