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Aliases for DPP8 Gene

Aliases for DPP8 Gene

  • Dipeptidyl Peptidase 8 2 3 5
  • Dipeptidyl Peptidase VIII 2 3 4
  • Prolyl Dipeptidase DPP8 2 3 4
  • Dipeptidyl Peptidase IV-Related Protein 1 3 4
  • DPP VIII 3 4
  • DPRP-1 3 4
  • DPRP1 3 4
  • DP8 3 4
  • Dipeptidyl Peptidase IV-Related Protein-1 2
  • Dipeptidyl-Peptidase 8 2
  • Dipeptidylpeptidase 8 2
  • EC 3.4.14.5 4
  • MSTP097 3
  • MSTP135 3
  • MSTP141 3
  • MST097 3

External Ids for DPP8 Gene

Previous GeneCards Identifiers for DPP8 Gene

  • GC15M061530
  • GC15M058838
  • GC15M063317
  • GC15M063454
  • GC15M063526
  • GC15M065734
  • GC15M042561

Summaries for DPP8 Gene

Entrez Gene Summary for DPP8 Gene

  • This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP8 Gene

DPP8 (Dipeptidyl Peptidase 8) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and dipeptidyl-peptidase activity. An important paralog of this gene is DPP9.

UniProtKB/Swiss-Prot for DPP8 Gene

  • Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.

Gene Wiki entry for DPP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP8 Gene

Genomics for DPP8 Gene

Regulatory Elements for DPP8 Gene

Enhancers for DPP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DPP8 on UCSC Golden Path with GeneCards custom track

Promoters for DPP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPP8 Gene

Chromosome:
15
Start:
65,442,463 bp from pter
End:
65,517,704 bp from pter
Size:
75,242 bases
Orientation:
Minus strand

Genomic View for DPP8 Gene

Genes around DPP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP8 Gene

Proteins for DPP8 Gene

  • Protein details for DPP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6V1X1-DPP8_HUMAN
    Recommended name:
    Dipeptidyl peptidase 8
    Protein Accession:
    Q6V1X1
    Secondary Accessions:
    • Q7Z4C8
    • Q7Z4D3
    • Q7Z4E1
    • Q8IWG7
    • Q8NEM5
    • Q96JX1
    • Q9HBM2
    • Q9HBM3
    • Q9HBM4
    • Q9HBM5
    • Q9NXF4

    Protein attributes for DPP8 Gene

    Size:
    898 amino acids
    Molecular mass:
    103358 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ13623.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAQ13650.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAQ13657.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91059.1; Type=Frameshift; Positions=486; Evidence={ECO:0000305}; Sequence=BAB55395.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DPP8 Gene

neXtProt entry for DPP8 Gene

Post-translational modifications for DPP8 Gene

  • Ubiquitination at Lys 388 and Lys 853
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DPP8 Gene

Domains & Families for DPP8 Gene

Gene Families for DPP8 Gene

Protein Domains for DPP8 Gene

Suggested Antigen Peptide Sequences for DPP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6V1X1

UniProtKB/Swiss-Prot:

DPP8_HUMAN :
  • Belongs to the peptidase S9B family. DPPIV subfamily.
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.
genes like me logo Genes that share domains with DPP8: view

Function for DPP8 Gene

Molecular function for DPP8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=208 uM for Ala-Pro-AMC {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=130 uM for Ala-Pro-AFC {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=120 uM for H-Ala-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=1420 uM for H-Ala-Ala-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=310 uM for H-Arg-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=2050 uM for H-Asp-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=480 uM for H-Gly-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; pH dependence: Optimum pH is 7.4-8.5. Little activity below pH 6.5. {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077};
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives.
UniProtKB/Swiss-Prot Function:
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.
UniProtKB/Swiss-Prot Induction:
In activated T-cells.

Enzyme Numbers (IUBMB) for DPP8 Gene

Gene Ontology (GO) - Molecular Function for DPP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity NAS 11012666
genes like me logo Genes that share ontologies with DPP8: view
genes like me logo Genes that share phenotypes with DPP8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DPP8

CRISPR Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPP8 Gene

Localization for DPP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPP8 Gene COMPARTMENTS Subcellular localization image for DPP8 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 11012666
genes like me logo Genes that share ontologies with DPP8: view

Pathways & Interactions for DPP8 Gene

SuperPathways for DPP8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 11012666
GO:0006955 immune response TAS 11012666
genes like me logo Genes that share ontologies with DPP8: view

No data available for Pathways by source and SIGNOR curated interactions for DPP8 Gene

Drugs & Compounds for DPP8 Gene

(3) Drugs for DPP8 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-[4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL]-1-(1,3-DIHYDROISOINDOL-2-YL)BUTANE-1,4-DIONE Pharma 0

(1) Additional Compounds for DPP8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DPP8: view

Transcripts for DPP8 Gene

Unigene Clusters for DPP8 Gene

Dipeptidyl-peptidase 8:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPP8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5:
SP6: - -
SP7: - - - - - - - -
SP8:
SP9:
SP10:

ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DPP8 Gene

GeneLoc Exon Structure for
DPP8
ECgene alternative splicing isoforms for
DPP8

Expression for DPP8 Gene

mRNA expression in normal human tissues for DPP8 Gene

Protein differential expression in normal tissues from HIPED for DPP8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Testis (7.1), and Monocytes (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPP8 Gene



Protein tissue co-expression partners for DPP8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPP8 Gene:

DPP8

SOURCE GeneReport for Unigene cluster for DPP8 Gene:

Hs.591106

mRNA Expression by UniProt/SwissProt for DPP8 Gene:

Q6V1X1-DPP8_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.
genes like me logo Genes that share expression patterns with DPP8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DPP8 Gene

Orthologs for DPP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPP8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPP8 34
  • 94.14 (n)
  • 98.11 (a)
DPP8 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPP8 34
  • 95.55 (n)
  • 98.78 (a)
DPP8 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp8 34
  • 89.38 (n)
  • 95.74 (a)
Dpp8 16
Dpp8 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPP8 34
  • 99.67 (n)
  • 100 (a)
DPP8 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP8 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPP8 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPP8 34
  • 79.71 (n)
  • 89.34 (a)
DPP8 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP8 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp8 34
  • 70.26 (n)
  • 79.71 (a)
Str.1167 34
zebrafish
(Danio rerio)
Actinopterygii CABZ01109647.1 35
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3744 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpf-3 34
  • 47.41 (n)
  • 36.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for DPP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP8 Gene

ENSEMBL:
Gene Tree for DPP8 (if available)
TreeFam:
Gene Tree for DPP8 (if available)

Paralogs for DPP8 Gene

Paralogs for DPP8 Gene

(1) SIMAP similar genes for DPP8 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with DPP8: view

Variants for DPP8 Gene

Sequence variations from dbSNP and Humsavar for DPP8 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3082806 -- 65,470,623(+) AAAAA(-/A/AA/AAA)GAATA intron-variant
rs3082807 -- 65,494,662(+) AAAAA(-/A/AAA/AAAA/AAAAA)GGGCA intron-variant
rs3177073 -- 65,443,022(-) TGTCT(C/T)CCTTG utr-variant-3-prime
rs3759852 -- 65,497,720(+) TACTT(C/T)TCTCC intron-variant
rs3784448 -- 65,508,518(+) ATGAA(C/T)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP8 Gene

Variant ID Type Subtype PubMed ID
dgv454e199 CNV deletion 23128226
esv3636756 CNV loss 21293372
esv3636757 CNV loss 21293372
nsv1138381 CNV deletion 24896259
nsv479032 CNV novel sequence insertion 20440878
nsv833042 CNV loss 17160897

Variation tolerance for DPP8 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPP8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP8 Gene

Disorders for DPP8 Gene

Relevant External Links for DPP8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPP8

No disorders were found for DPP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPP8 Gene

Publications for DPP8 Gene

  1. Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. (PMID: 11012666) Abbott C.A. … Gorrell M.D. (Eur. J. Biochem. 2000) 2 3 4 22 65
  2. Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. (PMID: 15664838) Jiaang W.-T. … Chen X. (Bioorg. Med. Chem. Lett. 2005) 3 4 22 65
  3. Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells. (PMID: 15039077) Chen Y.-S. … Chen X. (Protein Expr. Purif. 2004) 3 4 22 65
  4. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PMID: 12662155) Qi S.Y. … Akinsanya K.O. (Biochem. J. 2003) 3 4 22 65
  5. The in vivo expression of dipeptidyl peptidases 8 and 9. (PMID: 19581630) Yu D.M. … Gorrell M.D. (J. Histochem. Cytochem. 2009) 3 22 65

Products for DPP8 Gene

Sources for DPP8 Gene

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