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DPP8 Gene

protein-coding   GIFtS: 55
GCID: GC15M065734

Dipeptidyl-Peptidase 8

(Previous name: dipeptidylpeptidase 8)
  Search for DPP8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dipeptidyl-Peptidase 81 2     DPRP-12 3
Dipeptidyl Peptidase VIII1 2 3     DPRP12 3
Prolyl Dipeptidase DPP81 2 3     DPP VIII2 3
Dipeptidylpeptidase 81 2     MSTP1412
Dipeptidyl Peptidase IV-Related Protein-11 2     Dipeptidyl Peptidase 82
Dipeptidyl Peptidase IV-Related Protein 12 3     EC 3.4.14.53
DP82 3     

External Ids:    HGNC: 164901   Entrez Gene: 548782   Ensembl: ENSG000000746037   OMIM: 6068195   UniProtKB: Q6V1X13   

Export aliases for DPP8 gene to outside databases

Previous GC identifers: GC15M061530 GC15M058838 GC15M063317 GC15M063454 GC15M063526 GC15M042561


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPP8 Gene:
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to
cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in
that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like
dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively
spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPP8 Gene:
DPP8 (dipeptidyl-peptidase 8) is a protein-coding gene. GO annotations related to this gene include dipeptidyl-peptidase activity and serine-type peptidase activity. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot: DPP8_HUMAN, Q6V1X1
Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at
position 2. May play a role in T-cell activation and immune function

Gene Wiki entry for DPP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPP8 gene promoter:
         FOXO1a   AP-4   GATA-1   FOXO1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPP8 promoter sequence
   Search Chromatin IP Primers for DPP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22

DPP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP8 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M065734:  view genomic region     (about GC identifiers)

Start:
65,734,801 bp from pter      End:
65,810,042 bp from pter
Size:
75,242 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPP8_HUMAN, Q6V1X1 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 8  
Size: 898 amino acids; 103358 Da
Sequence caution: Sequence=AAQ13623.1; Type=Frameshift; Positions=Several; Sequence=AAQ13650.1; Type=Frameshift;
Positions=Several; Sequence=AAQ13657.1; Type=Erroneous initiation; Sequence=BAA91059.1; Type=Frameshift;
Positions=486; Sequence=BAB55395.1; Type=Erroneous initiation;
Secondary accessions: Q7Z4C8 Q7Z4D3 Q7Z4E1 Q8IWG7 Q8NEM5 Q96JX1 Q9HBM2 Q9HBM3 Q9HBM4 Q9HBM5
Q9NXF4
Alternative splicing: 6 isoforms:  Q6V1X1-1   Q6V1X1-2   Q6V1X1-3   Q6V1X1-4   Q6V1X1-5   Q6V1X1-6   

Explore the universe of human proteins at neXtProt for DPP8: NX_Q6V1X1

Explore proteomics data for DPP8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys388, Lys853, Lys896
  • Modification sites at PhosphoSitePlus

  • See DPP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_060213.2  NP_569118.1  NP_932064.1  NP_932065.1  

    ENSEMBL proteins: 
     ENSP00000339208   ENSP00000351817   ENSP00000300141   ENSP00000318111   ENSP00000454922  
     ENSP00000453954   ENSP00000379013   ENSP00000452643   ENSP00000455592   ENSP00000452719  
     ENSP00000453870   ENSP00000453756   ENSP00000316373   ENSP00000341230  

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    Cloud-Clone Corp. Proteins for DPP8

     
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    Search eBioscience for ELISAs for DPP8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001375 Peptidase_S9
     IPR002469 Peptidase_S9B

    Graphical View of Domain Structure for InterPro Entry Q6V1X1

    ProtoNet protein and cluster: Q6V1X1

    1 Blocks protein domain: IPB002469 Dipeptidylpeptidase IV (CD26)

    UniProtKB/Swiss-Prot: DPP8_HUMAN, Q6V1X1
    Similarity: Belongs to the peptidase S9B family. DPPIV subfamily


    Find genes that share domains with DPP8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPP8_HUMAN, Q6V1X1
    Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at
    position 2. May play a role in T-cell activation and immune function
    Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when
    Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
    Enzyme regulation: Inhibited by zinc. Inhibited by the serine proteinase inhibitor
    4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by
    isoindoline derivatives
    Biophysicochemical properties: Kinetic parameters: KM=208 uM for Ala-Pro-AMC; KM=130 uM for Ala-Pro-AFC; KM=120 uM
    for H-Ala-Pro-pNa; KM=1420 uM for H-Ala-Ala-pNa; KM=310 uM for H-Arg-Pro-pNa; KM=2050 uM for H-Asp-Pro-pNa;
    KM=480 uM for H-Gly-Pro-pNa; pH dependence: Optimum pH is 7.4-8.5. Little activity below pH 6.5;
    Induction: In activated T-cells

         Enzyme Number (IUBMB): EC 3.4.14.51

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008236serine-type peptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity NAS11012666
         
    Find genes that share ontologies with DPP8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DPP8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPP8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPP8
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    miRNA
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    hsa-mir-222-3p (MIRT046773), hsa-mir-93-5p (MIRT028120), hsa-mir-935 (MIRT036687)

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    Selected qRT-PCR Assays for microRNAs that regulate DPP8 (see all 50):
    hsa-miR-579 hsa-miR-520e hsa-miR-302d hsa-miR-3607-3p hsa-miR-99b* hsa-miR-519a hsa-miR-4275 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidDPP8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPP8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPP8_HUMAN, Q6V1X1: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS11012666
    GO:0016020membrane IEA--

    Find genes that share ontologies with DPP8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DPP8 About    
    See pathways by source

    SuperPathContained pathways About
    1gamma-glutamyl cycle
    gamma-glutamyl cycle


    1 BioSystems Pathway for DPP8
        gamma-glutamyl cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPP8
    Interactions:

        GeneGlobe Interaction Network for DPP8

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for DPP8 (Q6V1X13 ENSP000003392084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMRK1Q9NWW63I2D: score=3 
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    CHMP3ENSP000002638564STRING: ENSP00000263856
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS11012666
    GO:0006955immune response TAS11012666

    Find genes that share ontologies with DPP8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPP8

    3 Novoseek inferred chemical compound relationships for DPP8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 86.7 1 17328877 (1)
    proline 58.6 5 14687920 (1), 16186403 (1), 15039077 (1), 12941425 (1) (see all 5)
    serine 41.6 4 16186403 (1), 18538760 (1), 16704418 (1), 17223229 (1)



    Find genes that share compounds with DPP8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPP8 gene (4 alternative transcripts): 
    NM_017743.4  NM_130434.3  NM_197960.2  NM_197961.2  

    Unigene Cluster for DPP8:

    Dipeptidyl-peptidase 8
    Hs.591106  [show with all ESTs]
    Unigene Representative Sequence: BC040203
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341861(uc010bhi.3 uc002aov.3 uc002aow.3 uc010uiv.2 uc021soz.1 uc002aox.3 uc002aoy.3 uc002aoz.3 uc010bhj.3)
    ENST00000358939 ENST00000300141 ENST00000321147 ENST00000558786 ENST00000559233
    ENST00000395652 ENST00000560048 ENST00000558559 ENST00000560597 ENST00000558363
    ENST00000559526 ENST00000558529 ENST00000560436 ENST00000560194 ENST00000560665
    ENST00000321118 ENST00000339244(uc010bhk.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DPP8 (see all 50):
    hsa-miR-579 hsa-miR-520e hsa-miR-302d hsa-miR-3607-3p hsa-miR-99b* hsa-miR-519a hsa-miR-4275 hsa-miR-372
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      QuantiTect SYBR Green Assays in human, mouse, rat DPP8
      QuantiFast Probe-based Assays in human, mouse, rat DPP8

    Additional mRNA sequence: 

    AF173382.1 AF175225.1 AF176779.1 AF221634.1 AF221635.1 AF221636.1 AF221637.1 AK000290.1 
    AK027826.1 AK291057.1 AK296915.1 AK302638.1 AY172659.1 AY354202.1 BC030688.2 BC040203.1 

    11 DOTS entries:

    DT.95198188  DT.101983736  DT.414471  DT.100026767  DT.91977859  DT.100783134  DT.102826287  DT.95316684 
    DT.99983849  DT.428644  DT.95298703 

    Selected AceView cDNA sequences (see all 291):

    AW500277 CK906067 AA306656 BQ671635 AA937076 AI917735 AA148531 BC040203 
    AA708618 AA628894 AW275117 AA258527 BM910838 AY354202 BM677187 CB153590 
    NM_197960 AA769522 AW510810 AA312210 AI283576 BE504546 AA889818 AA812879 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DPP8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                      -     -                             -                                                                                 
    SP2:                          -     -     -     -                             -                                                                                 
    SP3:                          -     -     -     -     -                       -                                                                                 
    SP4:                          -     -     -     -     -                       -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:                          -                       -               
    SP2:                          -     -                 -               
    SP3:                          -                       -               
    SP4:                    -     -     -                 -               
    SP5:                    -     -                       -               


    ECgene alternative splicing isoforms for DPP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAAAATCA
    DPP8 Expression
    About this image


    DPP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    DPP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPP8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591106

    UniProtKB/Swiss-Prot: DPP8_HUMAN, Q6V1X1
    Tissue specificity: Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPP8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpp81 , 5 dipeptidylpeptidase 81, 5 89.38(n)1
    95.74(a)1
      9 (35.06 cM)5
    743881  NM_028906.21  NP_083182.21 
     650324585 
    chicken
    (Gallus gallus)
    Aves DPP81 dipeptidyl-peptidase 8 79.71(n)
    89.34(a)
      427512  XM_004943896.1  XP_004943953.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPP86
    dipeptidyl-peptidase 8
    84(a)
    1 ↔ 1
    GL343503.1(215752-240864)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.11672 Transcribed sequence with moderate similarity to protein more 77.3(n)    137696681 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01109647.16
    Uncharacterized protein
    28(a)
    many ↔ many
    9(58197841-58205377) ENSDARG00000078438
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37446
    --
    31(a)
    1 → many
    3R(20697503-20702366)
    worm
    (Caenorhabditis elegans)
    Secernentea dpf-31 dpf-3 47.41(n)
    36.65(a)
      172409  NM_059556.3  NP_491957.1 


    ENSEMBL Gene Tree for DPP8 (if available)
    TreeFam Gene Tree for DPP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPP8 gene
    FAP2  DPP102  DPP62  DPP92  DPP42  
    1 SIMAP similar gene for DPP8 using alignment to 9 protein entries:     DPP8_HUMAN (see all proteins):
    DPP9

    Find genes that share paralogs with DPP8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for DPP8 (see all 1579)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744200171,2
    F--65737586(+) CTCTAT/AGGGGA 4 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1823167521,2
    --65737752(+) ATCTAA/GCACCC 4 -- ds50010--------
    rs1877284981,2
    --65737919(+) CCAGGG/TATTAG 4 -- ds50010--------
    rs114551,2
    C,F,O,A,H--65737946(+) TATCTA/GTAAAC 4 -- ds500128Minor allele frequency- G:0.48MN EA NA NS WA CSA 2764
    rs285755761,2
    C,F--65738017(+) TTAAAT/CTTGTA 4 -- ut317Minor allele frequency- C:0.36NA WA EA 366
    rs719015401,2
    C--65738042(+) AAAAA-/AGAATT 4 -- ut310--------
    rs727394691,2
    C,F--65738080(+) GGAACT/CTTTCC 4 -- ut311Minor allele frequency- C:0.04NA 120
    rs1141780091,2
    C,F--65738331(+) ATTTTA/GATAAG 4 -- ut311Minor allele frequency- G:0.07WA 118
    rs341215781,2
    C,F--65738358(+) ACTGGC/TACCAC 4 -- ut318Minor allele frequency- T:0.37NA WA EA 368
    rs1910757161,2
    --65738464(+) GATTAA/CAAATT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for DPP8 (65734801 - 65810042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DPP8:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv454e199CNV Deletion23128226
    nsv833042CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPP8
    DNA2.0 Custom Variant and Variant Library Synthesis for DPP8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606819    OMIM disorders: --


    Find genes that share disorders with DPP8           About GenesLikeMe

    1 Novoseek inferred disease relationship for DPP8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver diseases 6.07 2 12675227 (1)


    Export disorders for DPP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPP8 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with DPP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. (PubMed id 11012666)1, 2, 3, 9 Abbott C.A....Gorrell M.D. (Eur. J. Biochem. 2000)
    2. Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. (PubMed id 15664838)1, 2, 9 Jiaang W.-T.... Chen X. (Bioorg. Med. Chem. Lett. 2005)
    3. Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells. (PubMed id 15039077)1, 2, 9 Chen Y.-S....Chen X. (Protein Expr. Purif. 2004)
    4. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PubMed id 12662155)1, 2, 9 Qi S.Y.... Akinsanya K.O. (Biochem. J. 2003)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family. (PubMed id 12534281)1, 2 Ajami K.... Gorrell M.D. (Biochemistry 2003)
    8. Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8. (PubMed id 17040910)1, 9 Lee H.J....Chen X. (J. Biol. Chem. 2006)
    9. Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. (PubMed id 16704418)1, 9 Yu D.M....Gorrell M.D. (FEBS J. 2006)
    10. The in vivo expression of dipeptidyl peptidases 8 and 9. (PubMed id 19581630)1, 9 Yu D.M....Gorrell M.D. (J. Histochem. Cytochem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54878 HGNC: 16490 AceView: DPP8 Ensembl:ENSG00000074603 euGenes: HUgn54878
    ECgene: DPP8 H-InvDB: DPP8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DPP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DPP8 gene:
    Search GeneIP for patents involving DPP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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