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Aliases for DPP8 Gene

Aliases for DPP8 Gene

  • Dipeptidyl-Peptidase 8 2 3
  • Dipeptidyl Peptidase VIII 2 3 4
  • Prolyl Dipeptidase DPP8 2 3 4
  • Dipeptidyl Peptidase IV-Related Protein-1 2 3
  • Dipeptidyl Peptidase IV-Related Protein 1 3 4
  • Dipeptidylpeptidase 8 2 3
  • DPP VIII 3 4
  • DPRP-1 3 4
  • DPRP1 3 4
  • DP8 3 4
  • Dipeptidyl Peptidase 8 3
  • EC 3.4.14.5 4
  • MSTP141 3

External Ids for DPP8 Gene

Summaries for DPP8 Gene

Entrez Gene Summary for DPP8 Gene

  • This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP8 Gene

DPP8 (Dipeptidyl-Peptidase 8) is a Protein Coding gene. Among its related pathways are gamma-glutamyl cycle. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot for DPP8 Gene

  • Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.

Gene Wiki entry for DPP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP8 Gene

Genomics for DPP8 Gene

Genomic Location for DPP8 Gene

Start:
65,442,463 bp from pter
End:
65,517,704 bp from pter
Size:
75,242 bases
Orientation:
Minus strand

Genomic View for DPP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP8 Gene

Regulatory Elements for DPP8 Gene

Proteins for DPP8 Gene

  • Protein details for DPP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6V1X1-DPP8_HUMAN
    Recommended name:
    Dipeptidyl peptidase 8
    Protein Accession:
    Q6V1X1
    Secondary Accessions:
    • Q7Z4C8
    • Q7Z4D3
    • Q7Z4E1
    • Q8IWG7
    • Q8NEM5
    • Q96JX1
    • Q9HBM2
    • Q9HBM3
    • Q9HBM4
    • Q9HBM5
    • Q9NXF4

    Protein attributes for DPP8 Gene

    Size:
    898 amino acids
    Molecular mass:
    103358 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ13623.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAQ13650.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAQ13657.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91059.1; Type=Frameshift; Positions=486; Evidence={ECO:0000305}; Sequence=BAB55395.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DPP8 Gene

neXtProt entry for DPP8 Gene

Proteomics data for DPP8 Gene at MOPED

Post-translational modifications for DPP8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys388, Lys853, and Lys896

No data available for DME Specific Peptides for DPP8 Gene

Domains for DPP8 Gene

Protein Domains for DPP8 Gene

UniProtKB/Swiss-Prot:

DPP8_HUMAN
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.:
    • Q6V1X1
genes like me logo Genes that share domains with DPP8: view

No data available for Gene Families for DPP8 Gene

Function for DPP8 Gene

Molecular function for DPP8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=208 uM for Ala-Pro-AMC {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=130 uM for Ala-Pro-AFC {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=120 uM for H-Ala-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=1420 uM for H-Ala-Ala-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=310 uM for H-Arg-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=2050 uM for H-Asp-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; KM=480 uM for H-Gly-Pro-pNa {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077}; pH dependence: Optimum pH is 7.4-8.5. Little activity below pH 6.5. {ECO:0000269 PubMed:12534281, ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15039077};
UniProtKB/Swiss-Prot CatalyticActivity: Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives.
UniProtKB/Swiss-Prot Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.
UniProtKB/Swiss-Prot Induction: In activated T-cells.

Enzyme Numbers (IUBMB) for DPP8 Gene

Gene Ontology (GO) - Molecular Function for DPP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity NAS 11012666
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with DPP8: view

Phenotypes for DPP8 Gene

GenomeRNAi human phenotypes for DPP8:
genes like me logo Genes that share phenotypes with DPP8: view

miRNA for DPP8 Gene

miRTarBase miRNAs that target DPP8

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DPP8 Gene

Localization for DPP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPP8 Gene COMPARTMENTS Subcellular localization image for DPP8 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 11012666
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DPP8: view

Pathways for DPP8 Gene

SuperPathways for DPP8 Gene

Superpath Contained pathways
1 gamma-glutamyl cycle
genes like me logo Genes that share pathways with DPP8: view

Pathways by source for DPP8 Gene

1 BioSystems pathway for DPP8 Gene

Interacting Proteins for DPP8 Gene

Gene Ontology (GO) - Biological Process for DPP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 11012666
GO:0006955 immune response TAS 11012666
genes like me logo Genes that share ontologies with DPP8: view

Compounds for DPP8 Gene

(3) Novoseek inferred chemical compound relationships for DPP8 Gene

Compound -log(P) Hits PubMed IDs
dpps 86.7 1
proline 58.6 5
serine 41.6 4
genes like me logo Genes that share compounds with DPP8: view

Transcripts for DPP8 Gene

Unigene Clusters for DPP8 Gene

Dipeptidyl-peptidase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPP8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5:
SP6: - -
SP7: - - - - - - - -
SP8:
SP9:
SP10:

ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DPP8 Gene

GeneLoc Exon Structure for
DPP8
ECgene alternative splicing isoforms for
DPP8

Expression for DPP8 Gene

mRNA expression in normal human tissues for DPP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPP8 Gene

SOURCE GeneReport for Unigene cluster for DPP8 Gene Hs.591106

mRNA Expression by UniProt/SwissProt for DPP8 Gene

Q6V1X1-DPP8_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.
genes like me logo Genes that share expressions with DPP8: view

Orthologs for DPP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP8 36
  • 99.67 (n)
  • 100 (a)
DPP8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPP8 36
  • 94.14 (n)
  • 98.11 (a)
DPP8 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPP8 36
  • 95.55 (n)
  • 98.78 (a)
DPP8 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp8 36
  • 89.38 (n)
  • 95.74 (a)
Dpp8 16
Dpp8 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP8 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPP8 37
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPP8 36
  • 79.71 (n)
  • 89.34 (a)
DPP8 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP8 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp8 36
  • 70.26 (n)
  • 79.71 (a)
Str.1167 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01109647.1 37
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3744 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpf-3 36
  • 47.41 (n)
  • 36.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToMany
Species with no ortholog for DPP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP8 Gene

ENSEMBL:
Gene Tree for DPP8 (if available)
TreeFam:
Gene Tree for DPP8 (if available)

Paralogs for DPP8 Gene

Paralogs for DPP8 Gene

Selected SIMAP similar genes for DPP8 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with DPP8: view

Variants for DPP8 Gene

Sequence variations from dbSNP and Humsavar for DPP8 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs7227 -- 65,442,518(+) TGCAA(C/G)AAAAC utr-variant-3-prime
rs11009 -- 65,446,965(+) TCTCC(A/C/T)GATTC synonymous-codon, reference, utr-variant-3-prime
rs11455 -- 65,445,608(+) TATCT(A/G)TAAAC downstream-variant-500B, utr-variant-3-prime
rs191608 -- 65,486,026(+) gaggc(A/G)gaggt intron-variant
rs352456 -- 65,483,773(+) acttg(G/T)acaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP8 Gene

Variant ID Type Subtype PubMed ID
nsv833042 CNV Loss 17160897
dgv454e199 CNV Deletion 23128226

Relevant External Links for DPP8 Gene

HapMap Linkage Disequilibrium report
DPP8

Disorders for DPP8 Gene

(1) Novoseek inferred disease relationships for DPP8 Gene

Disease -log(P) Hits PubMed IDs
liver diseases 6.07 1
genes like me logo Genes that share disorders with DPP8: view

No data available for UniProtKB/Swiss-Prot for DPP8 Gene

Publications for DPP8 Gene

  1. Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. (PMID: 11012666) Abbott C.A. … Gorrell M.D. (Eur. J. Biochem. 2000) 2 3 4 23
  2. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PMID: 12662155) Qi S.Y. … Akinsanya K.O. (Biochem. J. 2003) 3 4 23
  3. Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. (PMID: 15664838) Jiaang W.-T. … Chen X. (Bioorg. Med. Chem. Lett. 2005) 3 4 23
  4. Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells. (PMID: 15039077) Chen Y.-S. … Chen X. (Protein Expr. Purif. 2004) 3 4 23
  5. Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family. (PMID: 12534281) Ajami K. … Gorrell M.D. (Biochemistry 2003) 3 4

Products for DPP8 Gene

Sources for DPP8 Gene

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