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Aliases for DPP7 Gene

Aliases for DPP7 Gene

  • Dipeptidyl-Peptidase 7 2 3
  • QPP 3 4 6
  • Quiescent Cell Proline Dipeptidase 3 4
  • Dipeptidyl Aminopeptidase II 3 4
  • Dipeptidyl Peptidase II 3 4
  • DPP II 3 4
  • DPP2 3 4
  • Dipeptidyl Arylamidase II 3
  • Dipeptidyl-Peptidase II 3
  • Dipeptidyl Peptidase 2 3
  • Dipeptidyl Peptidase 7 4
  • Dipeptidylpeptidase 7 2
  • Carboxytripeptidase 3
  • EC 3.4.14.2 4
  • DPPII 3

External Ids for DPP7 Gene

Summaries for DPP7 Gene

Entrez Gene Summary for DPP7 Gene

  • The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP7 Gene

DPP7 (Dipeptidyl-Peptidase 7) is a Protein Coding gene. Diseases associated with DPP7 include chronic lymphocytic leukemia. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is PRCP.

UniProtKB/Swiss-Prot for DPP7 Gene

  • Plays an important role in the degradation of some oligopeptides.

Gene Wiki entry for DPP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP7 Gene

Genomics for DPP7 Gene

Genomic Location for DPP7 Gene

Start:
137,110,540 bp from pter
End:
137,115,177 bp from pter
Size:
4,638 bases
Orientation:
Minus strand

Genomic View for DPP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP7 Gene

Regulatory Elements for DPP7 Gene

Proteins for DPP7 Gene

  • Protein details for DPP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHL4-DPP2_HUMAN
    Recommended name:
    Dipeptidyl peptidase 2
    Protein Accession:
    Q9UHL4
    Secondary Accessions:
    • A8K7U7
    • Q5VSF1
    • Q969X4

    Protein attributes for DPP7 Gene

    Size:
    492 amino acids
    Molecular mass:
    54341 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DPP7 Gene

neXtProt entry for DPP7 Gene

Proteomics data for DPP7 Gene at MOPED

Post-translational modifications for DPP7 Gene

Other Protein References for DPP7 Gene

No data available for DME Specific Peptides for DPP7 Gene

Domains for DPP7 Gene

Gene Families for DPP7 Gene

Protein Domains for DPP7 Gene

UniProtKB/Swiss-Prot:

DPP2_HUMAN
Family:
  • Belongs to the peptidase S28 family.:
    • Q9UHL4
genes like me logo Genes that share domains with DPP7: view

Function for DPP7 Gene

Molecular function for DPP7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8.;
UniProtKB/Swiss-Prot CatalyticActivity: Release of an N-terminal dipeptide, Xaa-Yaa- -, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.
UniProtKB/Swiss-Prot Function: Plays an important role in the degradation of some oligopeptides.

Enzyme Numbers (IUBMB) for DPP7 Gene

Gene Ontology (GO) - Molecular Function for DPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA --
genes like me logo Genes that share ontologies with DPP7: view

miRNA for DPP7 Gene

miRTarBase miRNAs that target DPP7

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPP7 Gene

Localization for DPP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP7 Gene

Lysosome. Cytoplasmic vesicle. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPP7 Gene COMPARTMENTS Subcellular localization image for DPP7 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 3
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with DPP7: view

Pathways for DPP7 Gene

SuperPathways for DPP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DPP7: view

No data available for Pathways by source for DPP7 Gene

Compounds for DPP7 Gene

(6) Novoseek inferred chemical compound relationships for DPP7 Gene

Compound -log(P) Hits PubMed IDs
dpps 72.3 1
proline 67.2 20
serine 41 7
leucine 20.6 6
aspartate 15.6 1
genes like me logo Genes that share compounds with DPP7: view

Transcripts for DPP7 Gene

Unigene Clusters for DPP7 Gene

Dipeptidyl-peptidase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPP7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - -
SP2: - -
SP3: - - - - - - - - - -
SP4:
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - - - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 11b ^ 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for DPP7 Gene

GeneLoc Exon Structure for
DPP7
ECgene alternative splicing isoforms for
DPP7

Expression for DPP7 Gene

mRNA expression in normal human tissues for DPP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPP7 Gene

SOURCE GeneReport for Unigene cluster for DPP7 Gene Hs.37916

mRNA Expression by UniProt/SwissProt for DPP7 Gene

Q9UHL4-DPP2_HUMAN
Tissue specificity: Detected in seminal plasma (at protein level).
genes like me logo Genes that share expressions with DPP7: view

Orthologs for DPP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP7 36
  • 99.25 (n)
  • 99.19 (a)
DPP7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPP7 36
  • 81.63 (n)
  • 77.44 (a)
DPP7 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPP7 36
  • 82.57 (n)
  • 80.04 (a)
DPP7 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp7 36
  • 80.01 (n)
  • 81.33 (a)
Dpp7 16
Dpp7 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP7 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 41 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dpp7 36
  • 79.68 (n)
  • 80.17 (a)
chicken
(Gallus gallus)
Aves DPP7 36
  • 66.67 (n)
  • 66.16 (a)
DPP7 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP7 37
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11198 36
zebrafish
(Danio rerio)
Actinopterygii dpp7 36
  • 62.51 (n)
  • 59.47 (a)
dpp7 37
  • 54 (a)
OneToOne
wufb19g02 36
fruit fly
(Drosophila melanogaster)
Insecta CG9953 37
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F19C7.4 37
  • 19 (a)
ManyToMany
F56F10.1 38
  • 27 (a)
rice
(Oryza sativa)
Liliopsida Os11g0156200 36
  • 56.49 (n)
  • 44.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3666 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9152 37
  • 38 (a)
OneToOne
Species with no ortholog for DPP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DPP7 Gene

ENSEMBL:
Gene Tree for DPP7 (if available)
TreeFam:
Gene Tree for DPP7 (if available)

Paralogs for DPP7 Gene

Paralogs for DPP7 Gene

Selected SIMAP similar genes for DPP7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DPP7: view

Variants for DPP7 Gene

Sequence variations from dbSNP and Humsavar for DPP7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13631 -- 137,111,750(+) GCTCT(A/G)AGATC reference, synonymous-codon, stop-gained
rs1128114 -- 137,110,770(-) ACCCA(A/G)AAGAT missense, reference
rs1128115 -- 137,110,728(-) AGGCC(A/C)CCATC reference, missense, utr-variant-3-prime
rs1128125 -- 137,110,651(-) AGCCT(C/T)TGAGC reference, synonymous-codon, utr-variant-3-prime
rs1128129 -- 137,110,629(-) GGGGT(C/T)TCAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DPP7 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
nsv894550 CNV Gain 21882294
dgv8437n71 CNV Gain 21882294
dgv8439n71 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
nsv831761 CNV Loss 17160897
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
nsv894591 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
nsv894593 CNV Loss 21882294
nsv894595 CNV Loss 21882294
dgv8448n71 CNV Loss 21882294
dgv8449n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
esv2739410 CNV Deletion 23290073
esv1004020 CNV Insertion 20482838
esv1271276 CNV Insertion 17803354

Relevant External Links for DPP7 Gene

HapMap Linkage Disequilibrium report
DPP7

Disorders for DPP7 Gene

(3) Novoseek inferred disease relationships for DPP7 Gene

Disease -log(P) Hits PubMed IDs
chronic periodontitis 59.8 1
rheumatoid arthritis 4.23 1
tumors 0 2
genes like me logo Genes that share disorders with DPP7: view

No data available for UniProtKB/Swiss-Prot for DPP7 Gene

Publications for DPP7 Gene

  1. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. (PMID: 10477574) Chiravuri M. … Huber B.T. (J. Immunol. 1999) 2 3 23
  2. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. (PMID: 10567372) Underwood R. … Huber B.T. (J. Biol. Chem. 1999) 3 4 23
  3. Vesicular localization and characterization of a novel post-proline- cleaving aminodipeptidase, quiescent cell proline dipeptidase. (PMID: 11067927) Chiravuri M. … Huber B.T. (J. Immunol. 2000) 3 4 23
  4. Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase. (PMID: 11173530) Araki H. … Ohkubo I. (J. Biochem. 2001) 3 23
  5. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. (PMID: 12529175) Leiting B. … Thornberry N.A. (Biochem. J. 2003) 3 23

Products for DPP7 Gene

  • Addgene plasmids for DPP7

Sources for DPP7 Gene

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