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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPP7 Gene

protein-coding   GIFtS: 59
GCID: GC09M140004

Dipeptidyl-Peptidase 7

(Previous name: dipeptidylpeptidase 7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dipeptidyl-Peptidase 71 2     DPPII2
Dipeptidyl Aminopeptidase II2 3     carboxytripeptidase2
Dipeptidyl Peptidase II2 3     Dipeptidyl Arylamidase II2
Quiescent Cell Proline Dipeptidase2 3     Dipeptidyl Peptidase 22
DPP22 3     Dipeptidyl-Peptidase II2
QPP2 3     EC 3.4.14.23
DPP II2 3     Dipeptidyl Peptidase 73
Dipeptidylpeptidase 71     

External Ids:    HGNC: 148921   Entrez Gene: 299522   Ensembl: ENSG000001769787   OMIM: 6105375   UniProtKB: Q9UHL43   

Export aliases for DPP7 gene to outside databases

Previous GC identifers: GC00U990681 GC09M131696 GC09M133446 GC09M135362 GC09M137280 GC09M139124 GC09M109466


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPP7 Gene:
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The
resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of
this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at
both acidic and neutral pH. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPP7 Gene: 
DPP7 (dipeptidyl-peptidase 7) is a protein-coding gene. Diseases associated with DPP7 include lewy body dementia, and glanders. GO annotations related to this gene include dipeptidyl-peptidase activity and serine-type peptidase activity. An important paralog of this gene is PRSS16.

UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
Function: Plays an important role in the degradation of some oligopeptides

Gene Wiki entry for DPP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPP7 gene promoter:
         AhR   GR   GR-beta   Lmo2   Pax-2   Pax-2a   AP-4   Arnt   GR-alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

DPP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140004:  view genomic region     (about GC identifiers)

Start:
140,004,992 bp from pter      End:
140,009,629 bp from pter
Size:
4,638 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 2 precursor  
Size: 492 amino acids; 54341 Da
Subunit: Homodimer
Subcellular location: Lysosome. Cytoplasmic vesicle. Secreted
3 PDB 3D structures from and Proteopedia for DPP7:
3JYH (3D)        3N0T (3D)        4EBB (3D)    
Secondary accessions: A8K7U7 Q5VSF1 Q969X4

Explore the universe of human proteins at neXtProt for DPP7: NX_Q9UHL4

Explore proteomics data for DPP7 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHL4

  • DPP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPP7 Protein Expression
    REFSEQ proteins: NP_037511.2  
    ENSEMBL proteins: 
     ENSP00000360635   ENSP00000473354   ENSP00000473430   ENSP00000473309   ENSP00000473364  
     ENSP00000473618   ENSP00000473455  

    Human Recombinant Protein Products for DPP7: 
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    OriGene Protein Over-expression Lysate for DPP7
    OriGene MassSpec for DPP7 
    OriGene Custom Protein Services for DPP7
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    Novus Biologicals DPP7 Protein
    Novus Biologicals DPP7 Lysates
    Sino Biological Recombinant Protein for DPP7
    Sino Biological Cell Lysate for DPP7 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DPP7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IEA--
    GO:0005829cytosol IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    DPP7 for ontologies           About GeneDecksing



    DPP7 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DPP7 

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    Cloud-Clone Corp. CLIAs for DPP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Dipeptidyl-peptidase 7 
    Metallocarboxypeptidases

    1 InterPro protein domain:
     IPR008758 Peptidase_S28

    Graphical View of Domain Structure for InterPro Entry Q9UHL4

    ProtoNet protein and cluster: Q9UHL4

    2 Blocks protein domains:
    IPB000073 Alpha/beta hydrolase fold
    IPB008758 Peptidase S28


    UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
    Similarity: Belongs to the peptidase S28 family


    DPP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPP2_HUMAN, Q9UHL4
    Function: Plays an important role in the degradation of some oligopeptides
    Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa- -, preferentially when Yaa is Ala or Pro.
    Substrates are oligopeptides, preferentially tripeptides
    Biophysicochemical properties: pH dependence: Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8;

         Enzyme Number (IUBMB): EC 3.4.14.21

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008236serine-type peptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity IEA--
         
    DPP7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPP7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DPP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPP7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPP7 

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    miRTarBase miRNAs that target DPP7:
    hsa-mir-155 (MIRT001551)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPP7
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    Sino Biological Human cDNA Clone for DPP7
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                         Customized lentivirus expression plasmids for stable overexpression of DPP7 

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    Search LifeMap BioReagents cell lines for DPP7
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPP7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for DPP7 (Q9UHL42, 3 ENSP000003606354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRN1Q8IZH23, ENSP000002649514I2D: score=2 STRING: ENSP00000264951
    SLC2A4P146723I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    --Q9WMX22MINT-7048139
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    DPP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DPP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPP7 (DPP2)

    6 Novoseek inferred chemical compound relationships for DPP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 72.3 1 17328877 (1)
    proline 67.2 41 15487984 (3), 11067927 (2), 10867015 (2), 10567372 (2) (see all 13)
    serine 41 10 10567372 (2), 11067927 (1), 16186403 (1), 15686454 (1) (see all 6)
    leucine 20.6 8 10867015 (3), 11173530 (2), 7907802 (1)
    aspartate 15.6 1 10567372 (1)
    calcium 0 1 11067927 (1)

    Search CenterWatch for drugs/clinical trials and news about DPP7 / DPP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPP7 gene: 
    NM_013379.2  

    Unigene Cluster for DPP7:

    Dipeptidyl-peptidase 7
    Hs.37916  [show with all ESTs]
    Unigene Representative Sequence: AK128156
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371579(uc004clh.3) ENST00000470766 ENST00000473532 ENST00000463619
    ENST00000483783 ENST00000472306 ENST00000485456 ENST00000460830 ENST00000482088
    ENST00000478597(uc011meq.1) ENST00000497375 ENST00000491807 ENST00000473703


    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DPP7
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DPP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP7
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    Primer
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    OriGene qPCR primer pairs and template standards for DPP7
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPP7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPP7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP7

    Additional mRNA sequence: 

    AB209787.1 AF154502.1 AK128156.1 AK292112.1 AK293700.1 AK298288.1 BC011907.2 BC016961.1 
    BC018639.2 

    24 DOTS entries:

    DT.446187  DT.212570  DT.100030689  DT.100845512  DT.100845513  DT.121156819  DT.95372771  DT.95372777 
    DT.95372778  DT.100830548  DT.121156815  DT.121156842  DT.92444920  DT.95229657  DT.97775805  DT.100829296 
    DT.100845502  DT.100845503  DT.100845504  DT.100845509  DT.100845511  DT.40192788  DT.100665486  DT.121156793 

    24/437 AceView cDNA sequences (see all 437):

    CA391129 AA704884 CD624907 AA418493 AA232666 AI861842 AA635530 BQ893234 
    AI243912 AA459172 BX441984 BI820836 BQ957556 AA364341 BM926961 BX116886 
    BQ231380 N74985 BM685495 BQ181562 BU543302 CB154848 BM788161 BU190326 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for DPP7 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
    SP1:                                                  -                       -                                                                                 
    SP2:                                                  -                       -                                                                                 
    SP3:                                                  -                       -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                                                                                            
    SP5:                                                  -                       -     -     -     -     -     -                                                   

    ExUns: 11b ^ 12 ^ 13 ^ 14
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:  -                     
    SP5:                        


    ECgene alternative splicing isoforms for DPP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPP7 expression in normal human tissues (normalized intensities)      DPP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGGGGGC
    DPP7 Expression
    About this image


    DPP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Uncategorized (Uncategorized)
             PureStem progenitor W8

    See DPP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPP7

    SOURCE GeneReport for Unigene cluster: Hs.37916

    UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
    Tissue specificity: Detected in seminal plasma (at protein level)

        SABiosciences Custom PCR Arrays for DPP7
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPP7 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpp71 , 5 dipeptidylpeptidase 71, 5 79.84(n)1
    80.86(a)1
      2 (17.19 cM)5
    837681  NM_031843.21  NP_114031.21 
     253522765 
    chicken
    (Gallus gallus)
    Aves DPP71 dipeptidyl-peptidase 7 66.25(n)
    65.34(a)
      417297  XM_415570.3  XP_415570.2 
    lizard
    (Anolis carolinensis)
    Reptilia DPP76
    Uncharacterized protein
    48(a)
    1 ↔ 1
    GL344151.1(24072-44358)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb19g022 Transcribed sequence with weak similarity to protein more 74.82(n)    57053252 
    rice
    (Oryza sativa)
    Liliopsida AK068457.12   -- 75.3(n)    AK068457.1 


    ENSEMBL Gene Tree for DPP7 (if available)
    TreeFam Gene Tree for DPP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPP7 gene
    PRSS162  PRCP2  
    1 SIMAP similar gene for DPP7 using alignment to 7 protein entries:     DPP2_HUMAN (see all proteins):
    PRCP

    DPP7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/377 SNPs in DPP7 are shown (see all 377)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436936021,2
    --140004586(+) CAGCCA/GGAAAA 1 -- ds50010--------
    rs1808311901,2
    --140004620(+) AGACCG/TCCGAG 1 -- ds50010--------
    rs1852359991,2
    --140004643(+) GGGGCA/GTGGTC 1 -- ds50010--------
    rs1907906601,2
    --140004708(+) CAGTGG/TCCTCC 1 -- ds50010--------
    rs1822738651,2
    --140004710(+) GTGGCC/TTCCCC 1 -- ds50010--------
    rs1176219021,2
    C,F--140004726(+) GGGTCG/ACTGTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1395020901,2
    C--140004791(+) TGCTGC/TGGCTC 1 -- ds50010--------
    rs1435145671,2
    --140004804(+) CAGAGC/TGGGGC 1 -- ds50010--------
    rs2016101201,2
    C--140004826(+) CACTG-/CCCCCC 1 -- ds50010--------
    rs1872515241,2
    --140004832(+) CCCCCC/TGCTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DPP7 (140004992 - 140009629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/30 variations for DPP7 (see all 30):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739410CNV Deletion23290073
    esv2422220CNV Deletion17116639
    esv1004020CNV Insertion20482838
    esv1271276CNV Insertion17803354
    dgv8416n71CNV Loss21882294
    dgv8439n71CNV Loss21882294
    nsv894591CNV Loss21882294
    dgv8445n71CNV Loss21882294
    dgv8441n71CNV Loss21882294
    dgv8428n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610537    OMIM disorders: --

    20/23 diseases for DPP7 (see all 23):    About MalaCards
    lewy body dementia    glanders    gastroesophageal reflux disease    otitis media
    b-cell chronic lymphocytic leukemia    periodontitis    sjogren's syndrome    basal cell carcinoma
    gingivitis    dementia    cataract    huntington's disease
    osteoarthritis    chronic lymphocytic leukemia    rheumatoid arthritis    arthritis
    parkinson's disease    alzheimer's disease    esophagitis    thyroiditis


    DPP7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for DPP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic periodontitis 59.8 1 8884640 (1)
    rheumatoid arthritis 4.23 1 1679339 (1)
    tumors 0 4 8841504 (1), 1355397 (1)


    Export disorders for DPP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPP7 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with DPP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vesicular localization and characterization of a novel post-proline- cleaving aminodipeptidase, quiescent cell proline dipeptidase. (PubMed id 11067927)1, 2, 9 Chiravuri M.... Huber B.T. (2000)
    2. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. (PubMed id 10567372)1, 2, 9 Underwood R.... Huber B.T. (1999)
    3. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. (PubMed id 10477574)1, 3, 9 Chiravuri M....Huber B.T. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cloning and functional expression of rat kidney dipeptidyl peptidase II. (PubMed id 11139392)1, 3 Fukasawa K.M....Ota N. (2001)
    6. Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase. (PubMed id 11173530)1, 9 Araki H....Ohkubo I. (2001)
    7. Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). (PubMed id 15487984)2, 9 Maes M.B....De Meester I. (2005)
    8. Dipeptidyl peptidase 2 is an essential survival facto r in the regulation of cell quiescence. (PubMed id 19556882)1, 9 Mele D.A....Huber B.T. (2009)
    9. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. (PubMed id 12529175)1, 9 Leiting B....Thornberry N.A. (2003)
    10. Dipeptidyl peptidase II is not a marker for progression in melanoma. (PubMed id 18823758)1, 9 FrAPhlich E....Garbe C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29952 HGNC: 14892 AceView: DPP7 Ensembl:ENSG00000176978 euGenes: HUgn29952
    ECgene: DPP7 H-InvDB: DPP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPP7 gene:
    Search GeneIP for patents involving DPP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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