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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPP7 Gene

protein-coding   GIFtS: 54
GCID: GC09M140004

dipeptidyl-peptidase 7

(Previous name: dipeptidylpeptidase 7 )
 Explore 25 diseases affiliated with
DPP7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DPP7    

Aliases
for DPP7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dipeptidyl-Peptidase 71 2     Dipeptidylpeptidase 71
DPPII1 2     Carboxytripeptidase1
Dipeptidyl Aminopeptidase II2 3     Dipeptidyl Arylamidase II2
Dipeptidyl Peptidase II2 3     Dipeptidyl Peptidase 22
Quiescent Cell Proline Dipeptidase2 3     Dipeptidyl-Peptidase II2
DPP22 3     EC 3.4.14.23
QPP2 3     Dipeptidyl Peptidase 73
DPP II2 3     

External Ids:    HGNC: 148921   Entrez Gene: 299522   Ensembl: ENSG000001769787   OMIM: 6105375   UniProtKB: Q9UHL43   

Export aliases for DPP7 gene to outside databases

Previous GC identifers: GC00U990681 GC09M131696 GC09M133446 GC09M135362 GC09M137280 GC09M139124 GC09M109466


Summaries
for DPP7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DPP7:
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The
resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this
novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both
acidic and neutral pH. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
Function: Plays an important role in the degradation of some oligopeptides

Gene Wiki entry for DPP7


Genomic Views
for DPP7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPP7 gene promoter:
         AhR   GR   GR-beta   Lmo2   Pax-2   Pax-2a   AP-4   Arnt   GR-alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DPP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

DPP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140004:  view genomic region     (about GC identifiers)

Start:
 140,004,992 bp from pter      End:
 140,009,629 bp from pter
Size:
 4,638 bases      Orientation:
 minus strand

Proteins
for DPP7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 2 precursor  
Size: 492 amino acids; 54341 Da
Subunit: Homodimer
Subcellular location: Lysosome. Cytoplasmic vesicle. Secreted
3 PDB 3D structures from and Proteopedia for DPP7:
3JYH (3D)        3N0T (3D)        4EBB (3D)    
Secondary accessions: A8K7U7 Q5VSF1 Q969X4

Explore the universe of human proteins at neXtProt for DPP7: NX_Q9UHL4

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHL4

    • DPP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_037511.2  
    ENSEMBL proteins: 
     ENSP00000360635  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DPP7 (DPPII/QPP/DPP7)
    Enzo Life Sciences proteins for DPP7
    OriGene Purified Protein: DPP7
    OriGene Protein Over-expression Lysate: DPP7
    OriGene Custom Protein Services for DPP7 
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    Novus Biologicals DPP7 Protein
    Novus Biologicals DPP7 Lysates
    Sino Biological Recombinant Protein for DPP7
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DPP7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IEA--
    GO:0005829cytosol IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--


    DPP7 for ontologies           About GeneDecksing



    DPP7 Antibody Products: 
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    Uscn ELISAs and CLIAs for DPP7

    Protein Domains /
    Families
    for DPP7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DPP7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008758 Peptidase_S28

    Graphical View of Domain Structure for InterPro Entry Q9UHL4

    ProtoNet protein and cluster: Q9UHL4

    2 Blocks protein families:
    IPB000073 Alpha/beta hydrolase fold
    IPB008758 Peptidase S28


    UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
    Similarity: Belongs to the peptidase S28 family


    Function
    for DPP7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
    Function: Plays an important role in the degradation of some oligopeptides
    Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa- -, preferentially when Yaa is Ala or Pro. Substrates
    are oligopeptides, preferentially tripeptides
    Biophysicochemical properties: pH dependence: Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8;

    Enzyme Number (IUBMB): EC 3.4.14.21

    miRNA
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    hsa-mir-155 (MIRT001551)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPP7 (see all 7)
    OriGene shRNA RFP: DPP7
    OriGene siRNA: DPP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DPP7

    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DPP7 (NM_013379)
    Sino Biological Human cDNA Clone for DPP7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DPP7
    Search LifeMap BioReagents cell lines for DPP7

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DPP7

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008236serine-type peptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity IEA--


    DPP7 for ontologies           About GeneDecksing



    Pathways & Interactions
    for DPP7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPP7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for DPP7 (Q9UHL42, 3 ENSP000003606354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRN1Q8IZH23, ENSP000002649514I2D: score=2 STRING: ENSP00000264951
    SLC2A4P146723I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    --Q9WMX22MINT-7048139
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    DPP7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DPP7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DPP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPP7
    6 Novoseek chemical compound relationships for DPP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 72.3 1 17328877 (1)
    proline 67.2 41 15487984 (3), 11067927 (2), 10867015 (2), 10567372 (2) (see all 13)
    serine 41 10 10567372 (2), 11067927 (1), 16186403 (1), 15686454 (1) (see all 6)
    leucine 20.6 8 10867015 (3), 11173530 (2), 7907802 (1)
    aspartate 15.6 1 10567372 (1)
    calcium 0 1 11067927 (1)

    Search CenterWatch for drugs/clinical trials and news about DPP7 / DPP2 

    Transcripts
    for DPP7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DPP7 gene: 
    NM_013379.2  

    Unigene Cluster for DPP7:

    Dipeptidyl-peptidase 7
    Hs.37916  [show with all ESTs]
    Unigene Representative Sequence: AK128156
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371579(uc004clh.3) ENST00000470766 ENST00000473532 ENST00000463619
    ENST00000483783 ENST00000488415 ENST00000472306 ENST00000485456 ENST00000460830
    ENST00000482088 ENST00000478597(uc011meq.1) ENST00000497375 ENST00000491807
    ENST00000473703

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPP7
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPP7 (see all 7)
    OriGene shRNA RFP: DPP7
    OriGene siRNA: DPP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP7
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DPP7 (NM_013379)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP7 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPP7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP7

    Additional cDNA sequence: 

    AB209787.1 AF154502.1 AK128156.1 AK292112.1 AK293700.1 AK298288.1 BC011907.2 BC016961.1 
    BC018639.2 

    24 DOTS entries:

    DT.446187  DT.212570  DT.100030689  DT.100845512  DT.100845513  DT.121156819  DT.95372771  DT.95372777 
    DT.95372778  DT.100830548  DT.121156815  DT.121156842  DT.92444920  DT.95229657  DT.97775805  DT.100829296 
    DT.100845502  DT.100845503  DT.100845504  DT.100845509  DT.100845511  DT.40192788  DT.100665486  DT.121156793 

    24/437 AceView cDNA sequences (see all 437):

    BM788161 AA418493 CB154848 AA635530 BX441984 BQ181562 BQ957556 CD624907 
    BU543302 AA704884 AA364341 AI861842 BX116886 BM685495 BM926961 BQ231380 
    BQ893234 AA232666 BI820836 N74985 CA391129 AA459172 AI243912 BU145265 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for DPP7 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
    SP1:                                                  -                       -                                                                                 
    SP2:                                                  -                       -                                                                                 
    SP3:                                                  -                       -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                                                                                            
    SP5:                                                  -                       -     -     -     -     -     -                                                   

    ExUns: 11b ^ 12 ^ 13 ^ 14
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:  -                     
    SP5:                        


    ECgene alternative splicing isoforms for DPP7

    Expression
    for DPP7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTGGGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DPP7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DPP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPP7

    SOURCE GeneReport for Unigene cluster: Hs.37916

    UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
    Tissue specificity: Detected in seminal plasma (at protein level)

        SABiosciences Custom PCR Arrays for DPP7
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP7
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DPP7

    Orthologs
    for DPP7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPP7 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dpp71 , 5 dipeptidylpeptidase 71, 5 79.84(n)1
    80.86(a)1    		   2 (17.19 cM)5
    837681  NM_031843.21  NP_114031.21 
     253522765 
    chicken
    (Gallus gallus)    		 Aves DPP71 dipeptidyl-peptidase 7 66.25(n)
    65.34(a)    		   417297  XM_415570.3  XP_415570.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DPP76
    		 --
    		 48(a)
    		 1 ↔ 1
    		 GL344151.1(24072-43170)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb19g022 Transcribed sequence with weak similarity to protein more 74.82(n)    57053252 
    rice
    (Oryza sativa)    		 Liliopsida AK068457.12   -- 75.3(n)    AK068457.1 


    ENSEMBL Gene Tree for DPP7 (if available)
    TreeFam Gene Tree for DPP7 (if available) 

    Paralogs
    for DPP7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPP7 gene
    PRSS162  PRCP2  
    1 SIMAP similar gene for DPP7 using alignment to 1 protein entry:     DPP2_HUMAN:
    PRCP

    DPP7 for paralogs           About GeneDecksing



    Genomic Variants
    for DPP7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/262 NCBI SNPs in DPP7 are shown (see all 262)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1436936021,2
    		--140004586(+) CAGCCA/GGAAAA 1 -- ds50010--------
    rs1808311901,2
    		--140004620(+) AGACCG/TCCGAG 1 -- ds50010--------
    rs1852359991,2
    		--140004643(+) GGGGCA/GTGGTC 1 -- ds50010--------
    rs1907906601,2
    		--140004708(+) CAGTGG/TCCTCC 1 -- ds50010--------
    rs1822738651,2
    		--140004710(+) GTGGCC/TTCCCC 1 -- ds50010--------
    rs1176219021,2
    		--140004726(+) GGGTCG/ACTGTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1395020901,2
    		--140004791(+) TGCTGC/TGGCTC 1 -- ds50010--------
    rs1435145671,2
    		--140004804(+) CAGAGC/TGGGGC 1 -- ds50010--------
    rs2016101201,2
    		--140004826(+) CACTG-/CCCCCC 1 -- ds50010--------
    rs1872515241,2
    		--140004832(+) CCCCCC/TGCTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DPP7 (140004992 - 140009629 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for DPP7
         2 CNVs: 4663 5415

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    Disorders / Diseases
    for DPP7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DPP7 for disorders           About GeneDecksing

    OMIM gene information: 610537    OMIM disorders: --

    20/25 diseases for DPP7 (see all 25):    About MalaCards
    lewy body dementia    gastroesophageal reflux disease    otitis media    rheumatoid arthritis
    basal cell carcinoma    chronic lymphocytic leukemia    lymphocytic leukemia    glanders
    sjogren's syndrome    periodontitis    dementia    huntington's disease
    parkinson's disease    arthritis    cataract    gingivitis
    alzheimer's disease    osteoarthritis    lung carcinoma    leukemia

    3 Novoseek disease relationships for DPP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic periodontitis 59.8 1 8884640 (1)
    rheumatoid arthritis 4.23 1 1679339 (1)
    tumors 0 4 8841504 (1), 1355397 (1)


    Export disorders for DPP7 gene to outside databases

    Publications
    for DPP7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPP7 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with DPP7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Vesicular localization and characterization of a novel post-proline- cleaving aminodipeptidase, quiescent cell proline dipeptidase. (PubMed id 11067927)1, 2, 9 Chiravuri M.... Huber B.T. (2000)
    2. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. (PubMed id 10567372)1, 2, 9 Underwood R.... Huber B.T. (1999)
    3. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. (PubMed id 10477574)1, 3, 9 Chiravuri M....Huber B.T. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cloning and functional expression of rat kidney dipeptidyl peptidase II. (PubMed id 11139392)1, 3 Fukasawa K.M....Ota N. (2001)
    6. Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase. (PubMed id 11173530)1, 9 Araki H....Ohkubo I. (2001)
    7. Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). (PubMed id 15487984)2, 9 Maes M.B....De Meester I. (2005)
    8. Dipeptidyl peptidase 2 is an essential survival facto r in the regulation of cell quiescence. (PubMed id 19556882)1, 9 Mele D.A....Huber B.T. (2009)
    9. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. (PubMed id 12529175)1, 9 Leiting B....Thornberry N.A. (2003)
    10. Dipeptidyl peptidase II is not a marker for progression in melanoma. (PubMed id 18823758)1, 9 FrAPhlich E....Garbe C. (2009)

    External Searches for DPP7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing DPP7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29952 HGNC: 14892 AceView: DPP7 Ensembl:ENSG00000176978 euGenes: HUgn29952
    ECgene: DPP7 H-InvDB: DPP7

    Other Databases showing DPP7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DPP7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPP7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DPP7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DPP7 gene:
    Search GeneIP for patents involving DPP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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