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DPP7 Gene

protein-coding   GIFtS: 59
GCID: GC09M140004

Dipeptidyl-Peptidase 7

(Previous name: dipeptidylpeptidase 7)
  Search for DPP7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dipeptidyl-Peptidase 71 2     DPPII2
QPP2 3 5     carboxytripeptidase2
Dipeptidyl Aminopeptidase II2 3     Dipeptidyl Arylamidase II2
Dipeptidyl Peptidase II2 3     Dipeptidyl Peptidase 22
Quiescent Cell Proline Dipeptidase2 3     Dipeptidyl-Peptidase II2
DPP22 3     EC 3.4.14.23
DPP II2 3     Dipeptidyl Peptidase 73
Dipeptidylpeptidase 71     

External Ids:    HGNC: 148921   Entrez Gene: 299522   Ensembl: ENSG000001769787   OMIM: 6105375   UniProtKB: Q9UHL43   

Export aliases for DPP7 gene to outside databases

Previous GC identifers: GC00U990681 GC09M131696 GC09M133446 GC09M135362 GC09M137280 GC09M139124 GC09M109466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPP7 Gene:
The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The
resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of
this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at
both acidic and neutral pH. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPP7 Gene:
DPP7 (dipeptidyl-peptidase 7) is a protein-coding gene. GO annotations related to this gene include dipeptidyl-peptidase activity and serine-type peptidase activity. An important paralog of this gene is PRSS16.

UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
Function: Plays an important role in the degradation of some oligopeptides

Gene Wiki entry for DPP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPP7 gene promoter:
         AhR   GR   GR-beta   Lmo2   Pax-2   Pax-2a   AP-4   Arnt   GR-alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPP7 promoter sequence
   Search Chromatin IP Primers for DPP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

DPP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140004:  view genomic region     (about GC identifiers)

Start:
140,004,992 bp from pter      End:
140,009,629 bp from pter
Size:
4,638 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 2 precursor  
Size: 492 amino acids; 54341 Da
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for DPP7:
3JYH (3D)        3N0T (3D)        4EBB (3D)    
Secondary accessions: A8K7U7 Q5VSF1 Q969X4

Explore the universe of human proteins at neXtProt for DPP7: NX_Q9UHL4

Explore proteomics data for DPP7 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitination2 at Lys112, Lys228
  • Glycosylation2 at Asn50, Asn86, Asn315, Asn356, Asn363, Asn428
  • Modification sites at PhosphoSitePlus

  • See DPP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037511.2  
    ENSEMBL proteins: 
     ENSP00000360635   ENSP00000473354   ENSP00000473430   ENSP00000473309   ENSP00000473364  
     ENSP00000473618   ENSP00000473455  

    DPP7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DPP7
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    Novus Biologicals DPP7 Protein
    Novus Biologicals DPP7 Lysates
    Sino Biological Recombinant Protein for DPP7
    Sino Biological Cell Lysate for DPP7
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    Cloud-Clone Corp. Proteins for DPP7

     
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    DPP7 Assay Products:

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    Search eBioscience for ELISAs for DPP7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Dipeptidyl-peptidase 7
    Metallocarboxypeptidases

    1 InterPro protein domain:
     IPR008758 Peptidase_S28

    Graphical View of Domain Structure for InterPro Entry Q9UHL4

    ProtoNet protein and cluster: Q9UHL4

    2 Blocks protein domains:
    IPB000073 Alpha/beta hydrolase fold
    IPB008758 Peptidase S28


    UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
    Similarity: Belongs to the peptidase S28 family


    Find genes that share domains with DPP7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPP2_HUMAN, Q9UHL4
    Function: Plays an important role in the degradation of some oligopeptides
    Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa- -, preferentially when Yaa is Ala or Pro.
    Substrates are oligopeptides, preferentially tripeptides
    Biophysicochemical properties: pH dependence: Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8;

         Enzyme Number (IUBMB): EC 3.4.14.21

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008236serine-type peptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity IEA--
         
    Find genes that share ontologies with DPP7           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPP7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPP7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPP7

    miRNA
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    miRTarBase miRNAs that target DPP7:
    hsa-mir-155-5p (MIRT001551), hsa-mir-1 (MIRT023714)

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    GenScript: all cDNA clones in your preferred vector: DPP7 (NM_013379)
    Sino Biological Human cDNA Clone for DPP7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP7
    Addgene plasmids for DPP7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPP2_HUMAN, Q9UHL4: Lysosome. Cytoplasmic vesicle. Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    vacuole5
    golgi apparatus3
    cytosol2
    cytoskeleton1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IEA--
    GO:0005829cytosol IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with DPP7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPP7
    Interactions:

        Search GeneGlobe Interaction Network for DPP7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for DPP7 (Q9UHL42, 3 ENSP000003606354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRN1Q8IZH23, ENSP000002649514I2D: score=2 STRING: ENSP00000264951
    SLC2A4P146723I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    --Q9WMX22MINT-7048139
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with DPP7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPP7 (DPP2)

    6 Novoseek inferred chemical compound relationships for DPP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 72.3 1 17328877 (1)
    proline 67.2 41 15487984 (3), 11067927 (2), 10867015 (2), 10567372 (2) (see all 13)
    serine 41 10 10567372 (2), 11067927 (1), 16186403 (1), 15686454 (1) (see all 6)
    leucine 20.6 8 10867015 (3), 11173530 (2), 7907802 (1)
    aspartate 15.6 1 10567372 (1)
    calcium 0 1 11067927 (1)



    Find genes that share compounds with DPP7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPP7 gene: 
    NM_013379.2  

    Unigene Cluster for DPP7:

    Dipeptidyl-peptidase 7
    Hs.37916  [show with all ESTs]
    Unigene Representative Sequence: AK128156
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371579(uc004clh.3) ENST00000470766 ENST00000473532 ENST00000463619
    ENST00000483783 ENST00000472306 ENST00000485456 ENST00000460830 ENST00000482088
    ENST00000478597(uc011meq.1) ENST00000497375 ENST00000491807 ENST00000473703

    miRNA
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    GenScript: all cDNA clones in your preferred vector: DPP7 (NM_013379)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP7
    Addgene plasmids for DPP7 
    Primer
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    OriGene qPCR primer pairs and template standards for DPP7
    OriGene qSTAR qPCR primer pairs in human, mouse for DPP7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPP7
      QuantiTect SYBR Green Assays in human, mouse, rat DPP7
      QuantiFast Probe-based Assays in human, mouse, rat DPP7

    Additional mRNA sequence: 

    AB209787.1 AF154502.1 AK128156.1 AK292112.1 AK293700.1 AK298288.1 BC011907.2 BC016961.1 
    BC018639.2 

    24 DOTS entries:

    DT.446187  DT.212570  DT.100030689  DT.100845512  DT.100845513  DT.121156819  DT.95372771  DT.95372777 
    DT.95372778  DT.100830548  DT.121156815  DT.121156842  DT.92444920  DT.95229657  DT.97775805  DT.100829296 
    DT.100845502  DT.100845503  DT.100845504  DT.100845509  DT.100845511  DT.40192788  DT.100665486  DT.121156793 

    Selected AceView cDNA sequences (see all 437):

    CA391129 AA704884 CD624907 AA418493 AA232666 AI861842 AA635530 BQ893234 
    AI243912 AA459172 BX441984 BI820836 BQ957556 AA364341 BM926961 BX116886 
    BQ231380 N74985 BM685495 BQ181562 BU543302 CB154848 BM788161 AA360105 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DPP7 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
    SP1:                                                  -                       -                                                                                 
    SP2:                                                  -                       -                                                                                 
    SP3:                                                  -                       -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                                                                                            
    SP5:                                                  -                       -     -     -     -     -     -                                                   

    ExUns: 11b ^ 12 ^ 13 ^ 14
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:  -                     
    SP5:                        


    ECgene alternative splicing isoforms for DPP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGGGGGC
    DPP7 Expression
    About this image


    DPP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lung (Respiratory System)
     
     Testis (Reproductive System)
     
     Adipose (Muscoskeletal System)
     
     Adrenal Gland (Endocrine System)
    DPP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37916

    UniProtKB/Swiss-Prot: DPP2_HUMAN, Q9UHL4
    Tissue specificity: Detected in seminal plasma (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPP7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpp71 , 5 dipeptidylpeptidase 71, 5 80.01(n)1
    81.33(a)1
      2 (17.19 cM)5
    837681  NM_031843.21  NP_114031.21 
     253522765 
    chicken
    (Gallus gallus)
    Aves DPP71 dipeptidyl-peptidase 7 66.67(n)
    66.16(a)
      417297  XM_415570.4  XP_415570.3 
    lizard
    (Anolis carolinensis)
    Reptilia DPP76
    dipeptidyl-peptidase 7
    49(a)
    1 ↔ 1
    GL344151.1(24072-44358)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb19g022 Transcribed sequence with weak similarity to protein more 74.82(n)    57053252 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99536
    --
    23(a)
    many ↔ many
    3L(6962758-6964766)
    worm
    (Caenorhabditis elegans)
    Secernentea F56F10.13 peptidase 27(a)   X(907613-911176)   --
    rice
    (Oryza sativa)
    Liliopsida AK068457.12   -- 75.3(n)    AK068457.1 


    ENSEMBL Gene Tree for DPP7 (if available)
    TreeFam Gene Tree for DPP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPP7 gene
    PRSS162  PRCP2  
    1 SIMAP similar gene for DPP7 using alignment to 7 protein entries:     DPP2_HUMAN (see all proteins):
    PRCP

    Find genes that share paralogs with DPP7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPP7 (see all 377)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436936021,2
    --140004586(+) CAGCCA/GGAAAA 1 -- ds50010--------
    rs1808311901,2
    --140004620(+) AGACCG/TCCGAG 1 -- ds50010--------
    rs1852359991,2
    --140004643(+) GGGGCA/GTGGTC 1 -- ds50010--------
    rs1907906601,2
    --140004708(+) CAGTGG/TCCTCC 1 -- ds50010--------
    rs1822738651,2
    --140004710(+) GTGGCC/TTCCCC 1 -- ds50010--------
    rs1176219021,2
    C,F--140004726(+) GGGTCG/ACTGTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1395020901,2
    C--140004791(+) TGCTGC/TGGCTC 1 -- ds50010--------
    rs1435145671,2
    --140004804(+) CAGAGC/TGGGGC 1 -- ds50010--------
    rs2016101201,2
    C--140004826(+) CACTG-/CCCCCC 1 -- ds50010--------
    rs1872515241,2
    --140004832(+) CCCCCC/TGCTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DPP7 (140004992 - 140009629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DPP7 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739410CNV Deletion23290073
    esv2422220CNV Deletion17116639
    esv1004020CNV Insertion20482838
    esv1271276CNV Insertion17803354
    dgv8416n71CNV Loss21882294
    dgv8439n71CNV Loss21882294
    nsv894591CNV Loss21882294
    dgv8445n71CNV Loss21882294
    dgv8441n71CNV Loss21882294
    dgv8428n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DPP7
    DNA2.0 Custom Variant and Variant Library Synthesis for DPP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610537    OMIM disorders: --


    Find genes that share disorders with DPP7           About GenesLikeMe

    3 Novoseek inferred disease relationships for DPP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic periodontitis 59.8 1 8884640 (1)
    rheumatoid arthritis 4.23 1 1679339 (1)
    tumors 0 4 8841504 (1), 1355397 (1)


    Export disorders for DPP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPP7 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with DPP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vesicular localization and characterization of a novel post-proline- cleaving aminodipeptidase, quiescent cell proline dipeptidase. (PubMed id 11067927)1, 2, 9 Chiravuri M.... Huber B.T. (J. Immunol. 2000)
    2. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. (PubMed id 10567372)1, 2, 9 Underwood R.... Huber B.T. (J. Biol. Chem. 1999)
    3. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. (PubMed id 10477574)1, 3, 9 Chiravuri M....Huber B.T. (J. Immunol. 1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning and functional expression of rat kidney dipeptidyl peptidase II. (PubMed id 11139392)1, 3 Fukasawa K.M....Ota N. (Biochem. J. 2001)
    6. Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase. (PubMed id 11173530)1, 9 Araki H....Ohkubo I. (J. Biochem. 2001)
    7. Kinetic investigation of human dipeptidyl peptidase II (DPPII)- mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). (PubMed id 15487984)2, 9 Maes M.B.... De Meester I. (Biochem. J. 2005)
    8. Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. (PubMed id 19556882)1, 9 Mele D.A....Huber B.T. (Cell Cycle 2009)
    9. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. (PubMed id 12529175)1, 9 Leiting B....Thornberry N.A. (Biochem. J. 2003)
    10. Dipeptidyl peptidase II is not a marker for progression in melanoma. (PubMed id 18823758)1, 9 FrAPhlich E....Garbe C. (J. Dermatol. Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 29952 HGNC: 14892 AceView: DPP7 Ensembl:ENSG00000176978 euGenes: HUgn29952
    ECgene: DPP7 H-InvDB: DPP7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DPP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DPP7 gene:
    Search GeneIP for patents involving DPP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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