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Aliases for DPP7 Gene

Aliases for DPP7 Gene

  • Dipeptidyl Peptidase 7 2 3 4
  • Quiescent Cell Proline Dipeptidase 3 4
  • Dipeptidyl Aminopeptidase II 3 4
  • Dipeptidyl Peptidase II 3 4
  • DPP II 3 4
  • DPP2 3 4
  • QPP 3 4
  • Dipeptidyl Arylamidase II 3
  • Dipeptidyl-Peptidase II 3
  • Dipeptidyl-Peptidase 7 5
  • Dipeptidylpeptidase 7 2
  • Carboxytripeptidase 3
  • EC 4
  • DPPII 3

External Ids for DPP7 Gene

Previous GeneCards Identifiers for DPP7 Gene

  • GC00U990681
  • GC09M131696
  • GC09M133446
  • GC09M135362
  • GC09M137280
  • GC09M139124
  • GC09M140004
  • GC09M109466

Summaries for DPP7 Gene

Entrez Gene Summary for DPP7 Gene

  • The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP7 Gene

DPP7 (Dipeptidyl Peptidase 7) is a Protein Coding gene. Diseases associated with DPP7 include Periodontitis. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is PRCP.

UniProtKB/Swiss-Prot for DPP7 Gene

  • Plays an important role in the degradation of some oligopeptides.

Gene Wiki entry for DPP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP7 Gene

Genomics for DPP7 Gene

Regulatory Elements for DPP7 Gene

Enhancers for DPP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPP7 Gene

137,110,540 bp from pter
137,117,980 bp from pter
7,441 bases
Minus strand

Genomic View for DPP7 Gene

Genes around DPP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP7 Gene

Proteins for DPP7 Gene

  • Protein details for DPP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dipeptidyl peptidase 2
    Protein Accession:
    Secondary Accessions:
    • A8K7U7
    • Q5VSF1
    • Q969X4

    Protein attributes for DPP7 Gene

    492 amino acids
    Molecular mass:
    54341 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DPP7 Gene

neXtProt entry for DPP7 Gene

Proteomics data for DPP7 Gene at MOPED

Post-translational modifications for DPP7 Gene

  • N-glycosylated.
  • Ubiquitination at Lys 112 and Lys 228
  • Glycosylation at Asn 50, Asn 86, Asn 315, Asn 356, Asn 363, and Asn 428
  • Modification sites at PhosphoSitePlus

Other Protein References for DPP7 Gene

Antibody Products

  • R&D Systems Antibodies for DPP7 (DPPII/QPP/DPP7)

No data available for DME Specific Peptides for DPP7 Gene

Domains & Families for DPP7 Gene

Gene Families for DPP7 Gene

Protein Domains for DPP7 Gene

Suggested Antigen Peptide Sequences for DPP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S28 family.
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with DPP7: view

Function for DPP7 Gene

Molecular function for DPP7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8.;
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal dipeptide, Xaa-Yaa- -, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.
UniProtKB/Swiss-Prot Function:
Plays an important role in the degradation of some oligopeptides.

Enzyme Numbers (IUBMB) for DPP7 Gene

genes like me logo Genes that share phenotypes with DPP7: view

Animal Model Products

miRNA for DPP7 Gene

miRTarBase miRNAs that target DPP7

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPP7 Gene

Localization for DPP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP7 Gene

Lysosome. Cytoplasmic vesicle. Secreted.

Subcellular locations from

Jensen Localization Image for DPP7 Gene COMPARTMENTS Subcellular localization image for DPP7 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 5
vacuole 5
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005829 cytosol IEA --
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with DPP7: view

Pathways & Interactions for DPP7 Gene

SuperPathways for DPP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPP7 Gene


No data available for Pathways by source and SIGNOR curated interactions for DPP7 Gene

Drugs & Compounds for DPP7 Gene

(5) Drugs for DPP7 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UAMC00039 Pharma 0

(2) Additional Compounds for DPP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DPP7: view

Transcripts for DPP7 Gene

Unigene Clusters for DPP7 Gene

Dipeptidyl-peptidase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPP7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - -
SP2: - -
SP3: - - - - - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - - - - -
SP11: - - -
SP12: - - - -
SP13: -

ExUns: 11b ^ 12 ^ 13 ^ 14
SP4: -
SP9: -

Relevant External Links for DPP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPP7 Gene

mRNA expression in normal human tissues for DPP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPP7 Gene

This gene is overexpressed in Adrenal (7.2) and Salivary gland (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPP7 Gene

SOURCE GeneReport for Unigene cluster for DPP7 Gene Hs.37916

mRNA Expression by UniProt/SwissProt for DPP7 Gene

Tissue specificity: Detected in seminal plasma (at protein level).
genes like me logo Genes that share expression patterns with DPP7: view

Protein tissue co-expression partners for DPP7 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for DPP7 Gene

Orthologs for DPP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DPP7 35
  • 81.63 (n)
  • 77.44 (a)
DPP7 36
  • 77 (a)
(Canis familiaris)
Mammalia DPP7 35
  • 82.57 (n)
  • 80.04 (a)
DPP7 36
  • 76 (a)
(Mus musculus)
Mammalia Dpp7 35
  • 80.01 (n)
  • 81.33 (a)
Dpp7 16
Dpp7 36
  • 78 (a)
(Pan troglodytes)
Mammalia DPP7 35
  • 99.25 (n)
  • 99.19 (a)
DPP7 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dpp7 35
  • 79.68 (n)
  • 80.17 (a)
(Monodelphis domestica)
Mammalia DPP7 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
-- 36
  • 50 (a)
(Gallus gallus)
Aves DPP7 35
  • 66.67 (n)
  • 66.16 (a)
DPP7 36
  • 63 (a)
(Anolis carolinensis)
Reptilia DPP7 36
  • 49 (a)
(Danio rerio)
Actinopterygii dpp7 35
  • 62.51 (n)
  • 59.47 (a)
wufb19g02 35
dpp7 36
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11198 35
fruit fly
(Drosophila melanogaster)
Insecta CG9953 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea F56F10.1 37
  • 27 (a)
F19C7.4 36
  • 19 (a)
(Oryza sativa)
Liliopsida Os11g0156200 35
  • 56.49 (n)
  • 44.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3666 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9152 36
  • 38 (a)
Species with no ortholog for DPP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DPP7 Gene

Gene Tree for DPP7 (if available)
Gene Tree for DPP7 (if available)

Paralogs for DPP7 Gene

Paralogs for DPP7 Gene

(1) SIMAP similar genes for DPP7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DPP7: view

Variants for DPP7 Gene

Sequence variations from dbSNP and Humsavar for DPP7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10747049 - 137,114,298(+) CGAAG(C/G)CCGAG nc-transcript-variant, reference, synonymous-codon, missense
rs1128114 -- 137,110,770(-) ACCCA(A/G)AAGAT nc-transcript-variant, reference, missense
rs1128115 -- 137,110,728(-) AGGCC(A/C)CCATC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1128125 -- 137,110,651(-) AGCCT(C/T)TGAGC nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs1128129 -- 137,110,629(-) GGGGT(C/T)TCAAG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DPP7 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
nsv894550 CNV Gain 21882294
dgv8437n71 CNV Gain 21882294
dgv8439n71 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
nsv831761 CNV Loss 17160897
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
nsv894591 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
nsv894593 CNV Loss 21882294
nsv894595 CNV Loss 21882294
dgv8448n71 CNV Loss 21882294
dgv8449n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
esv2739410 CNV Deletion 23290073
esv1004020 CNV Insertion 20482838
esv1271276 CNV Insertion 17803354

Variation tolerance for DPP7 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DPP7 Gene

Disorders for DPP7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPP7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • chronic pericementitis
- elite association - COSMIC cancer census association via MalaCards
Search DPP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DPP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DPP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPP7 Gene

Publications for DPP7 Gene

  1. Vesicular localization and characterization of a novel post-proline- cleaving aminodipeptidase, quiescent cell proline dipeptidase. (PMID: 11067927) Chiravuri M. … Huber B.T. (J. Immunol. 2000) 3 4 23 67
  2. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. (PMID: 10477574) Chiravuri M. … Huber B.T. (J. Immunol. 1999) 2 3 23
  3. Dipeptidyl peptidase II is not a marker for progression in melanoma. (PMID: 18823758) FrAPhlich E. … Garbe C. (J. Dermatol. Sci. 2009) 3 23
  4. Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. (PMID: 19556882) Mele D.A. … Huber B.T. (Cell Cycle 2009) 3 23
  5. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. (PMID: 12529175) Leiting B. … Thornberry N.A. (Biochem. J. 2003) 3 23

Products for DPP7 Gene

Sources for DPP7 Gene