Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DPP6 Gene

Aliases for DPP6 Gene

  • Dipeptidyl Peptidase Like 6 2 3
  • Dipeptidyl-Peptidase 6 2 3 5
  • Dipeptidyl Peptidase VI 3 4
  • Dipeptidyl Peptidase 6 2 4
  • DPP VI 3 4
  • DPPX 3 4
  • Dipeptidyl Aminopeptidase IV-Related Protein 3
  • Dipeptidyl Aminopeptidase-Related Protein 4
  • Dipeptidyl Peptidase IV-Related Protein 3
  • Dipeptidyl Peptidase IV-Like Protein 4
  • Dipeptidylpeptidase VI 2
  • Dipeptidylpeptidase 6 2
  • MRD33 3
  • DPL1 3
  • VF2 3

External Ids for DPP6 Gene

Previous GeneCards Identifiers for DPP6 Gene

  • GC07P151996
  • GC07P152248
  • GC07P153064
  • GC07P153141
  • GC07P153187
  • GC07P153381
  • GC07P153584
  • GC07P147386
  • GC07P153748

Summaries for DPP6 Gene

Entrez Gene Summary for DPP6 Gene

  • This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for DPP6 Gene

DPP6 (Dipeptidyl Peptidase Like 6) is a Protein Coding gene. Diseases associated with DPP6 include Mental Retardation, Autosomal Dominant 33 and Ventricular Fibrillation, Paroxysmal Familial, 2. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is DPP4.

UniProtKB/Swiss-Prot for DPP6 Gene

  • Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).

Gene Wiki entry for DPP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP6 Gene

Genomics for DPP6 Gene

Regulatory Elements for DPP6 Gene

Enhancers for DPP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPP6 Gene

153,887,097 bp from pter
154,894,290 bp from pter
1,007,194 bases
Plus strand

Genomic View for DPP6 Gene

Genes around DPP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP6 Gene

Proteins for DPP6 Gene

  • Protein details for DPP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dipeptidyl aminopeptidase-like protein 6
    Protein Accession:

    Protein attributes for DPP6 Gene

    865 amino acids
    Molecular mass:
    97588 Da
    Quaternary structure:
    • Homodimer (in vitro) (PubMed:15476821). Interacts with KCND2 (PubMed:15454437, PubMed:18364354). Identified in a complex with KCND2 and KCNIP2 (PubMed:18364354). Forms an octomeric complex composed of four DPP6 subunits bound to the KCND2 tetramer (PubMed:18364354).
    • Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord and brainstem.

    Three dimensional structures from OCA and Proteopedia for DPP6 Gene

    Alternative splice isoforms for DPP6 Gene


neXtProt entry for DPP6 Gene

Proteomics data for DPP6 Gene at MOPED

Post-translational modifications for DPP6 Gene

  • N-glycosylated.
  • Glycosylation at Asn 173, Asn 319, Asn 404, Asn 471, Asn 535, Asn 566, and Asn 813
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DPP6 Gene

Domains & Families for DPP6 Gene

Protein Domains for DPP6 Gene

Suggested Antigen Peptide Sequences for DPP6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S9B family.
  • Belongs to the peptidase S9B family.
genes like me logo Genes that share domains with DPP6: view

Function for DPP6 Gene

Molecular function for DPP6 Gene

GENATLAS Biochemistry:
UniProtKB/Swiss-Prot Function:
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).
genes like me logo Genes that share phenotypes with DPP6: view

Human Phenotype Ontology for DPP6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DPP6 Gene

MGI Knock Outs for DPP6:

Animal Model Products

  • Taconic Biosciences Mouse Models for DPP6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DPP6 Gene

Localization for DPP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP6 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for DPP6 Gene COMPARTMENTS Subcellular localization image for DPP6 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA,IDA 18364354
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DPP6: view

Pathways & Interactions for DPP6 Gene

SuperPathways for DPP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072659 protein localization to plasma membrane ISS --
GO:1901379 regulation of potassium ion transmembrane transport ISS --
genes like me logo Genes that share ontologies with DPP6: view

No data available for Pathways by source and SIGNOR curated interactions for DPP6 Gene

Drugs & Compounds for DPP6 Gene

(2) Drugs for DPP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DPP6: view

Transcripts for DPP6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DPP6 Gene

No ASD Table

Relevant External Links for DPP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPP6 Gene

mRNA expression in normal human tissues for DPP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPP6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for DPP6 Gene

This gene is overexpressed in Brain (27.1), Frontal cortex (24.7), and Fetal Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPP6 Gene

SOURCE GeneReport for Unigene cluster for DPP6 Gene Hs.490684

mRNA Expression by UniProt/SwissProt for DPP6 Gene

Tissue specificity: Expressed predominantly in brain.
genes like me logo Genes that share expression patterns with DPP6: view

Protein tissue co-expression partners for DPP6 Gene

- Elite partner

Primer Products

Orthologs for DPP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DPP6 35
  • 87.1 (n)
  • 91.66 (a)
DPP6 36
  • 90 (a)
(Canis familiaris)
Mammalia DPP6 35
  • 88.9 (n)
  • 93.41 (a)
DPP6 36
  • 93 (a)
(Mus musculus)
Mammalia Dpp6 35
  • 85.18 (n)
  • 92.43 (a)
Dpp6 16
Dpp6 36
  • 93 (a)
(Pan troglodytes)
Mammalia DPP6 35
  • 98.36 (n)
  • 98.36 (a)
DPP6 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dpp6 35
  • 86.11 (n)
  • 92.9 (a)
(Monodelphis domestica)
Mammalia DPP6 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia DPP6 36
  • 85 (a)
(Gallus gallus)
Aves DPP6 35
  • 76.52 (n)
  • 81.86 (a)
DPP6 36
  • 81 (a)
(Anolis carolinensis)
Reptilia DPP6 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp6 35
  • 69.42 (n)
  • 71.63 (a)
(Danio rerio)
Actinopterygii dpp6b 35
  • 63.3 (n)
  • 60.9 (a)
dpp6a 36
  • 64 (a)
dpp6b 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11319 37
  • 33 (a)
CG9059 37
  • 27 (a)
(Caenorhabditis elegans)
Secernentea C27C12.7 37
  • 25 (a)
T23F1.7a 37
  • 27 (a)
T23F1.7b 37
  • 27 (a)
dpf-3 36
  • 15 (a)
Species with no ortholog for DPP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP6 Gene

Gene Tree for DPP6 (if available)
Gene Tree for DPP6 (if available)

Paralogs for DPP6 Gene

Paralogs for DPP6 Gene

(3) SIMAP similar genes for DPP6 Gene using alignment to 9 proteins: Pseudogenes for DPP6 Gene

genes like me logo Genes that share paralogs with DPP6: view

Variants for DPP6 Gene

Sequence variations from dbSNP and Humsavar for DPP6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3734960 - 154,892,443(+) ACTGC(C/T)GACAG reference, synonymous-codon, missense
VAR_073680 Mental retardation, autosomal dominant 33 (MRD33)
rs764723 -- 153,904,636(+) ATTGA(A/G)CGTCT intron-variant
rs768701 -- 154,451,867(-) ACCCC(A/G)TCCCA intron-variant
rs768702 -- 154,451,922(-) AGCAG(C/T)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP6 Gene

Variant ID Type Subtype PubMed ID
nsv889512 CNV Gain 21882294
esv2422311 CNV Duplication 17116639
nsv524774 CNV Gain 19592680
dgv2161e1 CNV Complex 17122850
nsv470399 CNV Loss 18288195
dgv2162e1 CNV Complex 17122850
dgv2163e1 CNV Complex 17122850
dgv238e55 CNV Gain 17911159
dgv7552n71 CNV Gain 21882294
dgv7553n71 CNV Gain 21882294
dgv7554n71 CNV Gain 21882294
nsv8237 CNV Gain+Loss 18304495
nsv469536 CNV Gain 16826518
nsv471648 CNV Gain+Loss 15918152
dgv7555n71 CNV Gain 21882294
dgv7556n71 CNV Gain 21882294
nsv824402 CNV Gain 20364138
dgv847n27 CNV Gain 19166990
nsv465231 CNV Loss 19166990
nsv527276 CNV Gain 19592680
nsv442079 CNV CNV 18776908
dgv7557n71 CNV Gain 21882294
dgv7558n71 CNV Gain 21882294
nsv824403 CNV Gain 20364138
nsv470400 CNV Gain 18288195
nsv818571 CNV Gain 17921354
dgv239e55 CNV Gain 17911159
nsv889548 CNV Gain 21882294
esv2735481 CNV Deletion 23290073
nsv889549 CNV Gain 21882294
nsv889550 CNV Gain 21882294
nsv889551 CNV Gain 21882294
esv2465998 CNV Loss 19546169
nsv469546 CNV Complex 16826518
nsv366534 CNV Insertion 16902084
nsv510122 CNV Loss 20534489
esv2735482 CNV Deletion 23290073
esv2669098 CNV Deletion 23128226
esv2666239 CNV Deletion 23128226
esv2735483 CNV Deletion 23290073
esv2735485 CNV Deletion 23290073
esv2735486 CNV Deletion 23290073
esv2660113 CNV Deletion 23128226
esv2735487 CNV Deletion 23290073
esv2735488 CNV Deletion 23290073
esv2735489 CNV Deletion 23290073
esv2735490 CNV Deletion 23290073
esv2735491 CNV Deletion 23290073
nsv365901 CNV Loss 16902084
nsv465236 CNV Loss 19166990
nsv526720 CNV Gain 19592680
nsv889552 CNV Loss 21882294
esv2735492 CNV Deletion 23290073
esv29693 CNV Loss 19812545
nsv527203 CNV Loss 19592680
dgv1148n67 CNV Loss 20364138
esv2735493 CNV Deletion 23290073
dgv1253e199 CNV Deletion 23128226
esv22392 CNV Loss 19812545
esv2735494 CNV Deletion 23290073
esv2637772 CNV Deletion 19546169
esv2025877 CNV Deletion 18987734
esv2664872 CNV Deletion 23128226
esv5151 CNV Deletion 18987735
esv2735496 CNV Deletion 23290073
esv2735497 CNV Deletion 23290073
nsv889553 CNV Loss 21882294
nsv518759 CNV Loss 19592680
esv2628794 CNV Insertion 19546169
esv273317 CNV Insertion 20981092
esv268774 CNV Insertion 20981092
nsv465238 CNV Loss 19166990
nsv831195 CNV Gain 17160897
esv2735498 CNV Deletion 23290073
esv1940735 CNV Deletion 18987734
esv2735499 CNV Deletion 23290073
nsv366921 CNV Loss 16902084
nsv512004 CNV Loss 21212237
esv4438 CNV Deletion 18987735
esv2735500 CNV Deletion 23290073
esv1610528 CNV Deletion 17803354
esv6277 CNV Loss 19470904
esv2662885 CNV Deletion 23128226
esv2659494 CNV Deletion 23128226
esv22669 CNV Loss 19812545
esv34081 CNV Loss 18971310
nsv6015 CNV Loss 18451855
esv2434145 CNV Insertion 19546169
esv1451910 CNV Insertion 17803354
nsv511372 CNV Loss 21212237
esv2540470 CNV Loss 19546169
esv991575 CNV Deletion 20482838
esv2602761 CNV Deletion 19546169
nsv512005 CNV Loss 21212237
esv2735501 CNV Deletion 23290073
esv1097647 CNV Deletion 17803354
esv2667815 CNV Deletion 23128226
nsv820692 CNV Deletion 20802225
esv24733 CNV Gain 19812545
nsv514460 CNV Loss 21397061
nsv442256 CNV CNV 18776908
esv1001960 CNV Loss 20482838
nsv366340 CNV Insertion 16902084
esv1110347 CNV Insertion 17803354
esv26207 CNV Gain+Loss 19812545
esv2606084 CNV Deletion 19546169
nsv366762 CNV Loss 16902084
esv2735502 CNV Deletion 23290073
esv1009254 CNV Loss 20482838
esv1692856 CNV Deletion 17803354
esv1004696 CNV Deletion 20482838
esv2735503 CNV Deletion 23290073
nsv820907 CNV Deletion 20802225
esv2735504 CNV Deletion 23290073
esv1263400 CNV Deletion 17803354
esv4397 CNV Deletion 18987735
esv2735505 CNV Deletion 23290073
esv1007428 CNV Loss 20482838
nsv821075 CNV Deletion 20802225
esv2735507 CNV Deletion 23290073
esv1296344 CNV Deletion 17803354
nsv366906 CNV Loss 16902084
esv1758390 CNV Deletion 17803354
esv4695 CNV Deletion 18987735
esv2735508 CNV Deletion 23290073
esv1443053 CNV Deletion 17803354
esv1371027 CNV Deletion 17803354
nsv366238 CNV Loss 16902084
esv2735509 CNV Deletion 23290073
esv2735510 CNV Deletion 23290073
esv2665978 CNV Deletion 23128226
esv2671914 CNV Deletion 23128226
esv988293 CNV Deletion 20482838
esv1294593 CNV Deletion 17803354
esv2735511 CNV Deletion 23290073
esv2735512 CNV Deletion 23290073
nsv6016 CNV Insertion 18451855
nsv509226 CNV Insertion 20534489
esv2735513 CNV Deletion 23290073
dgv1182e201 CNV Deletion 23290073
esv2735515 CNV Deletion 23290073
nsv507428 CNV Insertion 20534489
esv2735518 CNV Deletion 23290073
esv2561489 CNV Insertion 19546169
esv2735519 CNV Deletion 23290073
nsv523054 CNV Loss 19592680
esv2735520 CNV Deletion 23290073
esv2366894 CNV Deletion 18987734
esv4846 CNV Deletion 18987735
esv2735521 CNV Deletion 23290073
nsv365937 CNV Loss 16902084
esv998210 CNV Deletion 20482838
nsv483088 CNV Loss 15286789
nsv889554 CNV Loss 21882294
nsv889555 CNV Loss 21882294
nsv517537 CNV Loss 19592680
nsv889556 CNV Gain 21882294
esv2634055 CNV Deletion 19546169
esv2353387 CNV Deletion 18987734
esv2735522 CNV Deletion 23290073
esv2671112 CNV Deletion 23128226
dgv848n27 CNV Loss 19166990
esv2735523 CNV Deletion 23290073
esv8110 CNV Loss 19470904

Variation tolerance for DPP6 Gene

Gene Damage Index Score: 6.23; 76.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPP6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP6 Gene

Disorders for DPP6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for DPP6 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 33
  • mrd33
ventricular fibrillation, paroxysmal familial, 2
  • familial paroxysmal ventricular fibrillation 2
idiopathic ventricular fibrillation, not brugada type
  • familial paroxysmal ventricular fibrillation, not brugada type
autosomal dominant microcephaly
  • microcephaly autosomal dominant
paroxysmal ventricular fibrillation
  • idiopathic ventricular fibrillation
- elite association - COSMIC cancer census association via MalaCards
Search DPP6 in MalaCards View complete list of genes associated with diseases


  • Familial paroxysmal ventricular fibrillation 2 (VF2) [MIM:612956]: A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. {ECO:0000269 PubMed:19285295}. Note=The disease is caused by mutations affecting the gene represented in this entry. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2.
  • Mental retardation, autosomal dominant 33 (MRD33) [MIM:616311]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD33 patients manifest microcephaly and intellectual disability. {ECO:0000269 PubMed:23832105}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DPP6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DPP6: view

No data available for Genatlas for DPP6 Gene

Publications for DPP6 Gene

  1. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. (PMID: 18084291) van Es M.A. … van den Berg L.H. (Nat. Genet. 2008) 3 4 48 67
  2. A new TASK for Dipeptidyl Peptidase-like Protein 6. (PMID: 23593319) Nadin B.M. … Pfaffinger P.J. (PLoS ONE 2013) 2 3
  3. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 23
  4. Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. (PMID: 15890703) Radicke S. … Wettwer E. (J. Physiol. (Lond.) 2005) 3 23
  5. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PMID: 15454437) Jerng H.H. … Pfaffinger P.J. (Biophys. J. 2004) 3 23

Products for DPP6 Gene

Sources for DPP6 Gene