Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPP6 Gene

protein-coding   GIFtS: 56
GCID: GC07P153584

dipeptidyl-peptidase 6

(Previous names: dipeptidylpeptidase VI, dipeptidylpeptidase 6 )
 Explore 14 diseases affiliated with
DPP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DPP6    

Aliases
for DPP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dipeptidyl-Peptidase 61 2     Dipeptidyl Peptidase VI2 3
DPPX1 2 3     DPP VI2 3
Dipeptidylpeptidase 61 2     VF22 5
Dipeptidylpeptidase VI1 2     Dipeptidyl Aminopeptidase IV-Related Protein2
Dipeptidyl Aminopeptidase-Related Protein2 3     Dipeptidyl Aminopeptidase-Like Protein 62
Dipeptidyl Peptidase 62 3     Dipeptidyl Peptidase IV-Related Protein2
Dipeptidyl Peptidase IV-Like Protein2 3     

External Ids:    HGNC: 30101   Entrez Gene: 18042   Ensembl: ENSG000001302267   OMIM: 1261415   UniProtKB: P426583   

Export aliases for DPP6 gene to outside databases

Previous GC identifers: GC07P151996 GC07P152248 GC07P153064 GC07P153141 GC07P153187 GC07P153867 GC07P153381 GC07P147386


Summaries
for DPP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DPP6:
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine
proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine
residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated
potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DPP6_HUMAN, P42658
Function: May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity.
May modulate the cell surface expression and the activity of the potassium channel KCND2

Gene Wiki entry for DPP6


Genomic Views
for DPP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007741.14  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPP6 gene promoter:
         HOXA9   LHX3b/Lhx3b   Pax-6   NRSF form 1   NRSF form 2   Meis-1b   E47   FOXL1   Hand1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): DPP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.2   Ensembl cytogenetic band:  7q36.2   HGNC cytogenetic band: 7q36.2

DPP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P153584:  view genomic region     (about GC identifiers)

Start:
 153,584,182 bp from pter      End:
 154,685,995 bp from pter
Size:
 1,101,814 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 152,913,032-153,914,021     

Proteins
for DPP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPP6_HUMAN, P42658 (See protein sequence)
Recommended Name: Dipeptidyl aminopeptidase-like protein 6  
Size: 865 amino acids; 97588 Da
Subunit: Homodimer. Binds KCND2
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
Miscellaneous: Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a
severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord
and brainstem
1 PDB 3D structure from and Proteopedia for DPP6:
1XFD (3D)    
Alternative splicing: 2 isoforms:  P42658-1   P42658-2   

Explore the universe of human proteins at neXtProt for DPP6: NX_P42658

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42658

    • DPP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034439.1  NP_001927.3  NP_570629.2  

    ENSEMBL proteins: 
     ENSP00000385578   ENSP00000384393   ENSP00000367001   ENSP00000328226   ENSP00000397303  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DPP6
    OriGene Protein Over-expression Lysate (see all 2): DPP6
    OriGene Custom Protein Services for DPP6 
    GenScript Custom Purified and Recombinant Proteins Services for DPP6
    Novus Biologicals DPP6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DPP6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    DPP6 for ontologies           About GeneDecksing



    DPP6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DPP6
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DPP6 
    GenScript Custom Superior Antibodies Services for DPP6
    Novus Biologicals DPP6 Antibodies
    Search for Antibodies for DPP6 at Abcam  
    Uscn Antibodies for DPP6
    Search ThermoFisher Antibodies for DPP6

    Assay Products for DPP6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DPP6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DPP6

    Protein Domains /
    Families
    for DPP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DPP6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001375 Peptidase_S9
     IPR002469 Peptidase_S9B

    Graphical View of Domain Structure for InterPro Entry P42658

    ProtoNet protein and cluster: P42658

    1 Blocks protein family: IPB002469 Dipeptidylpeptidase IV (CD26)

    UniProtKB/Swiss-Prot: DPP6_HUMAN, P42658
    Similarity: Belongs to the peptidase S9B family


    Function
    for DPP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPP6_HUMAN, P42658
    Function: May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity.
    May modulate the cell surface expression and the activity of the potassium channel KCND2

         Genatlas biochemistry entry for DPP6:
    peptidase,dipeptidyl,related

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): DPP6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPP6
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate DPP6 (see all 21):
    hsa-miR-4307 hsa-miR-502-5p hsa-miR-181c hsa-miR-139-5p hsa-let-7a-2* hsa-miR-218 hsa-miR-374a* hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmid: DPP6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPP6 (see all 8)
    OriGene shRNA RFP: DPP6
    OriGene siRNA: DPP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DPP6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPP6 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPP6 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): DPP6 (NM_001039350)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DPP6
    Search LifeMap BioReagents cell lines for DPP6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP6

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008236serine-type peptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity TAS8103397


    DPP6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Dpp6tm1.1Dahn for DPP6
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Dpp6):
     nervous system 

    DPP6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DPP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPP6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for DPP6 (P426583 ENSP000003670014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=2 
    PHBP352323I2D: score=1 
    YWHABP319463I2D: score=1 
    --ENSP000003687484STRING: ENSP00000368748
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0008219cell death IEA--
    GO:0019228regulation of action potential in neuron IEA--
    GO:0042391regulation of membrane potential ----
    GO:0043266regulation of potassium ion transport IEA--


    DPP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DPP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DPP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPP6

    1 DrugBank Compound for DPP6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----

    2 Novoseek chemical compound relationships for DPP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 27.6 10 15476821 (2), 15454437 (1), 19153714 (1)
    serine 13.8 3 15476821 (2)

    Search CenterWatch for drugs/clinical trials and news about DPP6 

    Transcripts
    for DPP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DPP6 gene (3 alternative transcripts): 
    NM_001039350.1  NM_001936.3  NM_130797.2  

    Unigene Clusters for DPP6:

    Dipeptidyl-peptidase 6
    Hs.490684  [show with all ESTs], Hs.703229
    Unigene Representative Sequences: BC150304, BC035912
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404039(uc003wli.3 uc003wlk.3 uc003wlm.3 uc011kvq.2)
    ENST00000406326(uc003wlj.3) ENST00000377770 ENST00000462622(uc010lqh.1)
    ENST00000332007 ENST00000496611 ENST00000427557 ENST00000471100 ENST00000481593
    ENST00000478614 ENST00000493268 ENST00000484789 ENST00000488512 ENST00000479637
    ENST00000480367

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): DPP6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPP6
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate DPP6 (see all 21):
    hsa-miR-4307 hsa-miR-502-5p hsa-miR-181c hsa-miR-139-5p hsa-let-7a-2* hsa-miR-218 hsa-miR-374a* hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmid: DPP6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPP6 (see all 8)
    OriGene shRNA RFP: DPP6
    OriGene siRNA: DPP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPP6 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPP6 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): DPP6 (NM_001039350)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPP6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPP6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP6

    Additional cDNA sequence: BC035912.1 

    11 DOTS entries:

    DT.414649  DT.95219430  DT.440921  DT.121117482  DT.97768987  DT.100666576  DT.121117370  DT.121117587 
    DT.91640604  DT.86840214  DT.91801679 

    24/128 AceView cDNA sequences (see all 128):

    CB156686 AI370936 BG911121 BI039853 BU151391 BM931444 AL040127 BF529571 
    BI040394 CR619673 BE549875 BM680874 R88435 AI375070 AA364709 AA349837 
    BV203035 BU071057 BX431481 CA867310 AI494307 AI494123 BU077602 AI498246 

    GeneLoc Exon Structure


    Expression
    for DPP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAATAAAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DPP6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneSacral VertebraeOsteochondro Mesenchymal CellsBone, Cartilage
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    BrainStriatumBrain
    CartilageCervical Intervertebral DiscCartilage
    CartilageLumbar Intervertebral DiscCartilage
    CartilageThoracic Intervertebral DiscCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DPP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPP6

    SOURCE GeneReport for Unigene clusters: Hs.490684 Hs.703229

    UniProtKB/Swiss-Prot: DPP6_HUMAN, P42658
    Tissue specificity: Expressed predominantly in brain

        SABiosciences Custom PCR Arrays for DPP6
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPP6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPP6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPP6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP6

    Orthologs
    for DPP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DPP6 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DPP61 dipeptidyl-peptidase 6 76.72(n)
    82.1(a)    		   420440  XM_418545.2  XP_418545.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DPP66
    		 --
    		 76(a)
    		 1 ↔ 1
    		 6(5237981-5418401)
    zebrafish
    (Danio rerio)    		 Actinopterygii dpp6b1 dipeptidyl-peptidase 6b 63.34(n)
    60.9(a)    		   566832  NM_001115122.1  NP_001108594.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG113193 dipeptidyl-peptidase IV 33(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea T23F1.7a3 dipeptidyl peptidase IV 27(a)
    (best of 3)    		   V(15473968-15478599)   --


    ENSEMBL Gene Tree for DPP6 (if available)
    TreeFam Gene Tree for DPP6 (if available) 

    Paralogs
    for DPP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPP6 gene
    DPP82  FAP2  DPP102  DPP92  DPP42  
    3 SIMAP similar genes for DPP6 using alignment to 9 protein entries:     DPP6_HUMAN (see all proteins):
    DPP10    DPP4    FAP

    DPP6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DPP6
    PGOHUM00000233072


    Genomic Variants
    for DPP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5085 NCBI SNPs in DPP6 are shown (see all 5085)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs763231161,2
    		--152912227(+) GCCGCC/TGAGGG 1 -- us2k10--------
    rs389801,2
    		C,--152912387(-) TTGGCC/GTCTGC 1 -- us2k14Minor allele frequency- G:0.12NA WA EA 360
    rs1161378941,2
    		C,F,--152912447(+) ACAACA/GTTATT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs756777231,2
    		F,--152913396(+) AAGGCC/TATGAT 2 A syn11Minor allele frequency- T:0.04EA 120
    rs788475231,2
    		--152914174(+) CCTCGC/GCGCTC 1 -- int12Minor allele frequency- G:0.11CSA WA 120
    rs78066881,2
    		C,F,A,H,--152914293(+) GCCATT/CTTGTT 1 -- int17Minor allele frequency- C:0.22NS EA NA WA 540
    rs766855941,2
    		C,F,--152914364(+) GAAGAA/GTCCTC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs592218681,2
    		C,F,--152915909(+) ATACAC/TACAGA 1 -- int14Minor allele frequency- T:0.17WA CSA 124
    rs69564031,2
    		C,H,--152915964(+) GGACTC/TGCATT 1 -- int15Minor allele frequency- T:0.01NS EA WA 520
    rs731634251,2
    		C,--152916083(+) CTGCTC/TGCTGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DPP6 (153584182 - 153834182 bp, first 250kb of DPP6)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 119 variations for DPP6
         15/83 CNVs (see all 83): 82285 70091 100185 94985 94992 23831 94997 36651 82286 95009 100183 82281 94998 82284 64993
         15/36 Indels (see all 36): 41047 12976 82290 82303 47278 28505 100184 94983 28502 41049 28506 28503 82298 94988 82300
    Human Gene Mutation Database (HGMD): DPP6

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPP6
    DNA2.0 Custom Variant and Variant Library Synthesis for DPP6

    Disorders / Diseases
    for DPP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DPP6 for disorders           About GeneDecksing

    OMIM gene information: 126141   
    OMIM disorders: 612956  
    UniProtKB/Swiss-Prot: DPP6_HUMAN, P42658
  • Defects in DPP6 are the cause of familial paroxysmal ventricular fibrillation type 2 (VF2) [MIM:612956]. A
    • cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of
    myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. Note=A genetic
    variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular
    fibrillation type 2

    14 diseases for DPP6:    About MalaCards
    ventricular fibrillation, paroxysmal familial, 2    spinal muscular atrophy    ventricular fibrillation    amyotrophic lateral sclerosis (als)
    paroxysmal ventricular fibrillation    amyotrophic lateral sclerosis    muscular atrophy    progressive muscular atrophy
    lateral sclerosis    alzheimer's disease    colon cancer    pancreatic cancer
    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DPP6:
    Amyotrophic lateral sclerosis
    Human Genome Epidemiology (HuGE) Navigator: DPP6 (14 documents)

    Export disorders for DPP6 gene to outside databases

    Publications
    for DPP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPP6 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with DPP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. (PubMed id 15476821)1, 2, 9 Strop P....Brunger A.T. (2004)
    2. Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. (PubMed id 8103397)1, 2, 9 Yokotani N.... Wada K. (1993)
    3. Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. (PubMed id 19285295)1, 2 Alders M....Wilde A.A. (2009)
    4. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. (PubMed id 18084291)1, 2 van Es M.A.... van den Berg L.H. (2008)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. (PubMed id 1729689)1, 3 Wada K....Shimasaki S. (1992)
    7. Screening for replication of genome-wide SNP associations in sporadic ALS. (PubMed id 18987618)1, 9 Cronin S....Hardiman O. (2008)
    8. Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. (PubMed id 15890703)1, 9 Radicke S....Wettwer E. (2005)
    9. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PubMed id 15454437)1, 9 Jerng H.H.... Pfaffinger P.J. (2004)
    10. DPP6 as a candidate gene for neuroleptic-induced tardi ve dyskinesia. (PubMed id 21826085)1 Tanaka S....Arinami T. (2013)

    External Searches for DPP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DPP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1804 HGNC: 3010 AceView: DPP6 Ensembl:ENSG00000130226 euGenes: HUgn1804
    ECgene: DPP6 H-InvDB: DPP6

    Other Databases showing DPP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DPP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPP6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DPP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DPP6 gene:
    Search GeneIP for patents involving DPP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DPP6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for DPP6 (DPP6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DPP6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPP6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPP6  
     OriGene Protein Over-expression Lysate for DPP6   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DPP6   OriGene 3'-UTR Clone for DPP6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPP6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPP6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for DPP6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DPP6   OriGene Custom Protein Services for DPP6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPP6
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPP6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPP6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPP6
     GenScript Custom Purified and Recombinant Proteins Services for DPP6 GenScript cDNA clones with any tag delivered in your preferred vector for DPP6
     GenScript Custom Assay Services for DPP6 GenScript Custom Superior Antibodies Services for DPP6
     GenScript Custom overexpressing Cell Line Services for DPP6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DPP6 promoter
     Search Chromatin IP Primers for DPP6
     RT2 qPCR Primer Assay in human, mouse, rat DPP6
     GNC Network for DPP6
     SABiosciences Custom PCR Arrays for DPP6
     Search Tocris compounds for DPP6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DPP6 antibodies
     DPP6 lysates
     Search for Antibodies for DPP6 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DPP6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DPP6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DPP6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP6
     SwitchGear 3'UTR luciferase reporter plasmids for DPP6
     SwitchGear Promoter luciferase reporter plasmids for DPP6
     Search ThermoFisher Antibodies for DPP6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP6
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DPP6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4