Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DPP6 Gene

Aliases for DPP6 Gene

  • Dipeptidyl-Peptidase 6 2 3
  • Dipeptidyl Peptidase VI 3 4
  • DPP VI 3 4
  • DPPX 3 4
  • VF2 3 6
  • Dipeptidyl Aminopeptidase IV-Related Protein 3
  • Dipeptidyl Aminopeptidase-Related Protein 4
  • Dipeptidyl Aminopeptidase-Like Protein 6 3
  • Dipeptidyl Peptidase IV-Related Protein 3
  • Dipeptidyl Peptidase IV-Like Protein 4
  • Dipeptidylpeptidase VI 2
  • Dipeptidyl Peptidase 6 4
  • Dipeptidylpeptidase 6 2

External Ids for DPP6 Gene

Summaries for DPP6 Gene

Entrez Gene Summary for DPP6 Gene

  • This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for DPP6 Gene

DPP6 (Dipeptidyl-Peptidase 6) is a Protein Coding gene. Diseases associated with DPP6 include ventricular fibrillation, paroxysmal familial, 2 and autosomal dominant microcephaly. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot for DPP6 Gene

  • Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).

Gene Wiki entry for DPP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP6 Gene

Genomics for DPP6 Gene

Genomic Location for DPP6 Gene

Start:
153,748,189 bp from pter
End:
154,894,285 bp from pter
Size:
1,146,097 bases
Orientation:
Plus strand

Genomic View for DPP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP6 Gene

Regulatory Elements for DPP6 Gene

Proteins for DPP6 Gene

  • Protein details for DPP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42658-DPP6_HUMAN
    Recommended name:
    Dipeptidyl aminopeptidase-like protein 6
    Protein Accession:
    P42658
    Secondary Accessions:

    Protein attributes for DPP6 Gene

    Size:
    865 amino acids
    Molecular mass:
    97588 Da
    Quaternary structure:
    • Homodimer (in vitro) (PubMed:15476821). Interacts with KCND2 (PubMed:15454437, PubMed:18364354). Identified in a complex with KCND2 and KCNIP2 (PubMed:18364354). Forms an octomeric complex composed of four DPP6 subunits bound to the KCND2 tetramer (PubMed:18364354).
    Miscellaneous:
    • Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord and brainstem

    Three dimensional structures from OCA and Proteopedia for DPP6 Gene

    Alternative splice isoforms for DPP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPP6 Gene

Proteomics data for DPP6 Gene at MOPED

Post-translational modifications for DPP6 Gene

  • N-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn173, Asn319, Asn404, Asn471, Asn535, Asn566, and Asn813

No data available for DME Specific Peptides for DPP6 Gene

Domains for DPP6 Gene

Protein Domains for DPP6 Gene

Suggested Antigen Peptide Sequences for DPP6 Gene

Graphical View of Domain Structure for InterPro Entry

P42658

UniProtKB/Swiss-Prot:

DPP6_HUMAN
Family:
  • Belongs to the peptidase S9B family.:
    • P42658
genes like me logo Genes that share domains with DPP6: view

No data available for Gene Families for DPP6 Gene

Function for DPP6 Gene

Molecular function for DPP6 Gene

GENATLAS Biochemistry: peptidase,dipeptidyl,related
UniProtKB/Swiss-Prot Function: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).

Gene Ontology (GO) - Molecular Function for DPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008236 serine-type peptidase activity IEA --
GO:0008239 NOT dipeptidyl-peptidase activity IDA 8103397
GO:0015459 potassium channel regulator activity ISS --
genes like me logo Genes that share ontologies with DPP6: view

Phenotypes for DPP6 Gene

MGI mutant phenotypes for DPP6:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with DPP6: view

Animal Models for DPP6 Gene

MGI Knock Outs for DPP6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DPP6 Gene

Localization for DPP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP6 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPP6 Gene COMPARTMENTS Subcellular localization image for DPP6 gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0008076 voltage-gated potassium channel complex IDA 18364354
GO:0016020 membrane --
GO:0016021 integral component of membrane IDA 18364354
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DPP6: view

Pathways for DPP6 Gene

SuperPathways for DPP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008219 cell death --
GO:0019228 neuronal action potential IEA --
GO:0042391 regulation of membrane potential --
GO:0043266 regulation of potassium ion transport --
genes like me logo Genes that share ontologies with DPP6: view

No data available for Pathways by source for DPP6 Gene

Compounds for DPP6 Gene

(1) Drugbank Compounds for DPP6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target

(2) Novoseek inferred chemical compound relationships for DPP6 Gene

Compound -log(P) Hits PubMed IDs
potassium 27.6 4
serine 13.8 2
genes like me logo Genes that share compounds with DPP6: view

Transcripts for DPP6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DPP6 Gene

No ASD Table

Relevant External Links for DPP6 Gene

GeneLoc Exon Structure for
DPP6
ECgene alternative splicing isoforms for
DPP6

Expression for DPP6 Gene

mRNA expression in normal human tissues for DPP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPP6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DPP6 Gene

SOURCE GeneReport for Unigene cluster for DPP6 Gene Hs.490684

mRNA Expression by UniProt/SwissProt for DPP6 Gene

P42658-DPP6_HUMAN
Tissue specificity: Expressed predominantly in brain
genes like me logo Genes that share expressions with DPP6: view

Orthologs for DPP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP6 35
  • 98.36 (n)
  • 98.36 (a)
DPP6 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPP6 35
  • 87.1 (n)
  • 91.66 (a)
DPP6 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPP6 35
  • 88.9 (n)
  • 93.41 (a)
DPP6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp6 35
  • 85.18 (n)
  • 92.43 (a)
Dpp6 16
Dpp6 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP6 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPP6 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpp6 35
  • 86.11 (n)
  • 92.9 (a)
chicken
(Gallus gallus)
Aves DPP6 35
  • 76.52 (n)
  • 81.86 (a)
DPP6 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP6 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp6 35
  • 69.42 (n)
  • 71.63 (a)
zebrafish
(Danio rerio)
Actinopterygii dpp6a 36
  • 64 (a)
OneToMany
dpp6b 35
  • 63.3 (n)
  • 60.9 (a)
dpp6b 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11319 37
  • 33 (a)
CG9059 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea dpf-3 36
  • 15 (a)
OneToMany
T23F1.7b 37
  • 27 (a)
C27C12.7 37
  • 25 (a)
T23F1.7a 37
  • 27 (a)
Species with no ortholog for DPP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP6 Gene

ENSEMBL:
Gene Tree for DPP6 (if available)
TreeFam:
Gene Tree for DPP6 (if available)

Paralogs for DPP6 Gene

Paralogs for DPP6 Gene

Selected SIMAP similar genes for DPP6 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for DPP6 Gene

genes like me logo Genes that share paralogs with DPP6: view

Variants for DPP6 Gene

Sequence variations from dbSNP and Humsavar for DPP6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3298 -- 154,894,163(-) GTAGT(C/T)GTTCA utr-variant-3-prime
rs28886 -- 153,876,754(-) gtacc(C/T)tctat intron-variant
rs38973 -- 153,900,326(-) AATGG(A/G)GCATT intron-variant
rs38974 -- 153,900,171(-) CTTCA(C/T)CACAA intron-variant
rs38975 -- 153,899,641(-) AAACT(A/G)TTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP6 Gene

Variant ID Type Subtype PubMed ID
nsv889512 CNV Gain 21882294
esv2422311 CNV Duplication 17116639
nsv524774 CNV Gain 19592680
dgv2161e1 CNV Complex 17122850
nsv470399 CNV Loss 18288195
dgv2162e1 CNV Complex 17122850
dgv2163e1 CNV Complex 17122850
dgv238e55 CNV Gain 17911159
dgv7552n71 CNV Gain 21882294
dgv7553n71 CNV Gain 21882294
dgv7554n71 CNV Gain 21882294
nsv8237 CNV Gain+Loss 18304495
nsv469536 CNV Gain 16826518
nsv471648 CNV Gain+Loss 15918152
dgv7555n71 CNV Gain 21882294
dgv7556n71 CNV Gain 21882294
nsv824402 CNV Gain 20364138
dgv847n27 CNV Gain 19166990
nsv465231 CNV Loss 19166990
nsv527276 CNV Gain 19592680
nsv442079 CNV CNV 18776908
dgv7557n71 CNV Gain 21882294
dgv7558n71 CNV Gain 21882294
nsv824403 CNV Gain 20364138
nsv470400 CNV Gain 18288195
nsv818571 CNV Gain 17921354
dgv239e55 CNV Gain 17911159
nsv889548 CNV Gain 21882294
esv2735481 CNV Deletion 23290073
nsv889549 CNV Gain 21882294
nsv889550 CNV Gain 21882294
nsv889551 CNV Gain 21882294
esv2465998 CNV Loss 19546169
nsv469546 CNV Complex 16826518
nsv366534 CNV Insertion 16902084
nsv510122 CNV Loss 20534489
esv2735482 CNV Deletion 23290073
esv2669098 CNV Deletion 23128226
esv2666239 CNV Deletion 23128226
esv2735483 CNV Deletion 23290073
esv2735485 CNV Deletion 23290073
esv2735486 CNV Deletion 23290073
esv2660113 CNV Deletion 23128226
esv2735487 CNV Deletion 23290073
esv2735488 CNV Deletion 23290073
esv2735489 CNV Deletion 23290073
esv2735490 CNV Deletion 23290073
esv2735491 CNV Deletion 23290073
nsv365901 CNV Loss 16902084
nsv465236 CNV Loss 19166990
nsv526720 CNV Gain 19592680
nsv889552 CNV Loss 21882294
esv2735492 CNV Deletion 23290073
esv29693 CNV Loss 19812545
nsv527203 CNV Loss 19592680
dgv1148n67 CNV Loss 20364138
esv2735493 CNV Deletion 23290073
dgv1253e199 CNV Deletion 23128226
esv22392 CNV Loss 19812545
esv2735494 CNV Deletion 23290073
esv2637772 CNV Deletion 19546169
esv2025877 CNV Deletion 18987734
esv2664872 CNV Deletion 23128226
esv5151 CNV Deletion 18987735
esv2735496 CNV Deletion 23290073
esv2735497 CNV Deletion 23290073
nsv889553 CNV Loss 21882294
nsv518759 CNV Loss 19592680
esv2628794 CNV Insertion 19546169
esv273317 CNV Insertion 20981092
esv268774 CNV Insertion 20981092
nsv465238 CNV Loss 19166990
nsv831195 CNV Gain 17160897
esv2735498 CNV Deletion 23290073
esv1940735 CNV Deletion 18987734
esv2735499 CNV Deletion 23290073
nsv366921 CNV Loss 16902084
nsv512004 CNV Loss 21212237
esv4438 CNV Deletion 18987735
esv2735500 CNV Deletion 23290073
esv1610528 CNV Deletion 17803354
esv6277 CNV Loss 19470904
esv2662885 CNV Deletion 23128226
esv2659494 CNV Deletion 23128226
esv22669 CNV Loss 19812545
esv34081 CNV Loss 18971310
nsv6015 CNV Loss 18451855
esv2434145 CNV Insertion 19546169
esv1451910 CNV Insertion 17803354
nsv511372 CNV Loss 21212237
esv2540470 CNV Loss 19546169
esv991575 CNV Deletion 20482838
esv2602761 CNV Deletion 19546169
nsv512005 CNV Loss 21212237
esv2735501 CNV Deletion 23290073
esv1097647 CNV Deletion 17803354
esv2667815 CNV Deletion 23128226
nsv820692 CNV Deletion 20802225
esv24733 CNV Gain 19812545
nsv514460 CNV Loss 21397061
nsv442256 CNV CNV 18776908
esv1001960 CNV Loss 20482838
nsv366340 CNV Insertion 16902084
esv1110347 CNV Insertion 17803354
esv26207 CNV Gain+Loss 19812545
esv2606084 CNV Deletion 19546169
nsv366762 CNV Loss 16902084
esv2735502 CNV Deletion 23290073
esv1009254 CNV Loss 20482838
esv1692856 CNV Deletion 17803354
esv1004696 CNV Deletion 20482838
esv2735503 CNV Deletion 23290073
nsv820907 CNV Deletion 20802225
esv2735504 CNV Deletion 23290073
esv1263400 CNV Deletion 17803354
esv4397 CNV Deletion 18987735
esv2735505 CNV Deletion 23290073
esv1007428 CNV Loss 20482838
nsv821075 CNV Deletion 20802225
esv2735507 CNV Deletion 23290073
esv1296344 CNV Deletion 17803354
nsv366906 CNV Loss 16902084
esv1758390 CNV Deletion 17803354
esv4695 CNV Deletion 18987735
esv2735508 CNV Deletion 23290073
esv1443053 CNV Deletion 17803354
esv1371027 CNV Deletion 17803354
nsv366238 CNV Loss 16902084
esv2735509 CNV Deletion 23290073
esv2735510 CNV Deletion 23290073
esv2665978 CNV Deletion 23128226
esv2671914 CNV Deletion 23128226
esv988293 CNV Deletion 20482838
esv1294593 CNV Deletion 17803354
esv2735511 CNV Deletion 23290073
esv2735512 CNV Deletion 23290073
nsv6016 CNV Insertion 18451855
nsv509226 CNV Insertion 20534489
esv2735513 CNV Deletion 23290073
dgv1182e201 CNV Deletion 23290073
esv2735515 CNV Deletion 23290073
nsv507428 CNV Insertion 20534489
esv2735518 CNV Deletion 23290073
esv2561489 CNV Insertion 19546169
esv2735519 CNV Deletion 23290073
nsv523054 CNV Loss 19592680
esv2735520 CNV Deletion 23290073
esv2366894 CNV Deletion 18987734
esv4846 CNV Deletion 18987735
esv2735521 CNV Deletion 23290073
nsv365937 CNV Loss 16902084
esv998210 CNV Deletion 20482838
nsv483088 CNV Loss 15286789
nsv889554 CNV Loss 21882294
nsv889555 CNV Loss 21882294
nsv517537 CNV Loss 19592680
nsv889556 CNV Gain 21882294
esv2634055 CNV Deletion 19546169
esv2353387 CNV Deletion 18987734
esv2735522 CNV Deletion 23290073
esv2671112 CNV Deletion 23128226
dgv848n27 CNV Loss 19166990
esv2735523 CNV Deletion 23290073
esv8110 CNV Loss 19470904

Relevant External Links for DPP6 Gene

HapMap Linkage Disequilibrium report
DPP6
Human Gene Mutation Database (HGMD)
DPP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP6 Gene

Disorders for DPP6 Gene

(1) OMIM Diseases for DPP6 Gene (126141)

UniProtKB/Swiss-Prot

DPP6_HUMAN
  • Familial paroxysmal ventricular fibrillation 2 (VF2) [MIM:612956]: A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. {ECO:0000269 PubMed:19285295}. Note=The disease is caused by mutations affecting the gene represented in this entry. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2.

(1) University of Copenhagen DISEASES for DPP6 Gene

Relevant External Links for DPP6

Genetic Association Database (GAD)
DPP6
Human Genome Epidemiology (HuGE) Navigator
DPP6
genes like me logo Genes that share disorders with DPP6: view

Publications for DPP6 Gene

  1. Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. (PMID: 8103397) Yokotani N. … Wada K. (Hum. Mol. Genet. 1993) 3 4 23
  2. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PMID: 15454437) Jerng H.H. … Pfaffinger P.J. (Biophys. J. 2004) 3 4 23
  3. Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. (PMID: 15476821) Strop P. … Brunger A.T. (J. Mol. Biol. 2004) 3 4 23
  4. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 23 48
  5. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. (PMID: 18084291) van Es M.A. … van den Berg L.H. (Nat. Genet. 2008) 3 4 48

Products for DPP6 Gene

Sources for DPP6 Gene

Back to Top

Content