Aliases for DPP6 Gene
External Ids for DPP6 Gene
Previous GeneCards Identifiers for DPP6 Gene
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for DPP6 Gene
DPP6 (Dipeptidyl Peptidase Like 6) is a Protein Coding gene. Diseases associated with DPP6 include Mental Retardation, Autosomal Dominant 33 and Ventricular Fibrillation, Paroxysmal Familial, 2. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is DPP4.
UniProtKB/Swiss-Prot for DPP6 Gene
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).