DPP4 Gene
protein-coding GIFtS : 73 GCID: GC02 M162812
dipeptidyl-peptidase 4 dipeptidylpeptidase IV (CD26, adenosine deaminase complexing... CD26, ADCP2 )
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Aliasesfor DPP4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Dipeptidyl-Peptidase 4 1 2 ADCP-22 3 ADCP21 2 3 5 TP1032 3 CD261 2 3 5 DPP IV2 3 Adenosine Deaminase Complexing Protein 21 2 3 T-Cell Activation Antigen CD262 3 DPPIV1 2 EC 3.4.14.53 8 Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2)1 2 Dipeptidyl Peptidase 42 Dipeptidyl Peptidase IV2 3 Dipeptidylpeptidase 42 ADABP2 3 CD26 Antigen3
Export aliases for DPP4 gene to outside databases Previous GC identifers: GC02M160902 GC02M161376 GC02M163051 GC02M162674 GC02M162557 GC02M154730
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Summariesfor DPP4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DPP4 : The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487 Function : Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor(TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline summary
for DPP4 : Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has rolesin nutrition, metabolism, the immune and endocrine systems, bone marrow mobilization, cancer growth and celladhesion. DDP-IV catalyzes the hydrolysis of N-terminal dipeptides from polypeptides with proline or alaninein the penultimate position. This enzyme has many natural substrates including GLP-1, GIP, PACAP 38, NPY andGRP. DPP-IV exists as a homodimer and each monomer consists of two domains; an alpha/beta hydrolase domainand an eight-blade beta-propeller domain. DDP-IV binds to, but does not cleave, adenosine deaminase, kidneyNa+/H+ ion exchanger and fibronectin, which localizes these molecules to the cell surface. A soluble form ofDDP-IV does also exist, although it is only known to function in relation to T-cell proliferation. The humangene encoding DPP-IV is localized to chromosome 2q24.2. Gene Wiki entry for DPP4 (Dipeptidyl peptidase-4)
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Genomic Viewsfor DPP4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DPP4 gene promoter:AML1a Other transcription factors Search SABiosciences Chromatin IP Primers for DPP4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q23-qter DPP4 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M162812: view genomic region
(about GC identifiers )
Start: 162,848,751 bp from pter End:
162,931,052 bp from pter
Size: 82,302 bases Orientation:
minus strand
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Proteinsfor DPP4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487 See
protein sequence )Recommended Name: Size : 766 amino acids; 88279 DaSubunit : Monomer. Homodimer or heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidylpeptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3
Subcellular location : Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluidSubcellular location : Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type IImembrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction. Membrane raft. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface
Miscellaneous : Level of plasma concentrations of the soluble form (SDPP) can be managed as a colon carcinoma diagnosticand prognostic marker
6/74 PDB 3D structures from (see all 74 ):1J2E (3D) 1N1M (3D) 1NU6 (3D) 1NU8 (3D) 1PFQ (3D) 1R9M (3D) Secondary accessions : Q53TN1Explore the universe of human proteins at neXtProt for DPP4: NX_P27487 Post-translational modifications:
The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing1
N- and O-Glycosylated1 Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P27487 4/12 DME Specific Peptides for DPP4 (P27487 ) (see all 12 )DPP4 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001926.2 ENSEMBL proteins: ENSP00000353731 ENSP00000402259 ENSP00000401359 ENSP00000410264 Reactome Protein details: P27487 Human Recombinant Protein Products for DPP4: Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17 ): About this table
About GeneDecksing DPP4 Antibody Products: Assay Products for DPP4:
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Protein
Domains /for DPP4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P27487 ProtoNet protein and cluster: P27487
2 Blocks protein families : IPB002469 IPB002471 UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487 Domain : The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimaldipeptidyl peptidase activity Similarity : Belongs to the peptidase S9B family. DPPIV subfamily
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Functionfor DPP4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: DPP4_HUMAN, P27487 Function : Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor(TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline Catalytic activity : Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when Yaa isPro, provided Zaa is neither Pro nor hydroxyproline Enzyme regulation : Inhibited by GPC3 and diprotin AInduction : Up-regulated by IL12/interleukin-12 on activated T-cells. IL12-activated cells expressed enhanced levels ofDPP4 but not mRNAs. Down-regulated by TNF. Up-regulated in migratory endothelial cells and in the invasive endothelial cells in tumors
Genatlas biochemistry entry for DPP4 peptidase,dipeptidyl IV (intestinal),regulated by hepatocyte nuclear factor 1 alpha Enzyme Number (IUBMB): EC 3.4.14.5 1 2 Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing Phenotypes: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dpp4) :About GeneDecksing Animal Models: Dpp4 tm1Nwa for DPP4Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DPP4 (NM_001935 ) Sino Biological Human cDNA Clone for DPP4 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPP4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DPP4
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP4
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Pathways & Interactionsfor DPP4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 2 Selected targets of HNF1 3 Protein digestion and absorption 4 Insulin Processing 5 Asparagine N-linked glycosylation
Pathway sources See GeneCards unified pathways Show all pathways 1 5 1 (Kegg details for DPP4) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPP4 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/53 Interacting proteins for DPP4 (P27487 2 , 3 ENSP00000353731 4 via UniProtKB, MINT, STRING , and/or I2D (see all 53 )Interactant Interaction Details GeneCard External ID(s) CCL11 P51671 2 , 3 ENSP00000302234 4 MINT-8090954 I2D:
score=2 STRING: ENSP00000302234 CXCL11 O14625 2 , 3 ENSP00000306884 4 MINT-8091131 I2D:
score=2 STRING: ENSP00000306884 CXCL12 P48061 2 , 3 ENSP00000363548 4 MINT-8091118 I2D:
score=2 STRING: ENSP00000363548 CXCL9 Q07325 2 , 3 ENSP00000354901 4 MINT-8091083 I2D:
score=2 STRING: ENSP00000354901 GHRH P01286 2 , 3 ENSP00000237527 4 MINT-8090823 I2D:
score=1 STRING: ENSP00000237527
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing
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Drugs & Compoundsfor DPP4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for DPP4
Compounds for DPP4 available from Tocris Bioscience About this table Compound Action
CAS
# K 579 Dipeptidyl peptidase IV (DPP-IV) inhibitor [440100-64-1] PK 44 phosphate Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor [1017682-65-3] NVP DPP 728 dihydrochloride Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor [247016-69-9] DPPI 1c hydrochloride Dipeptidyl peptidase IV (DPP-IV) inhibitor [866396-34-1]
1 HMDB Compound for DPP4 About this table 10/49 DrugBank Compounds for DPP4 (see all 49 )About this table Compound Synonyms
CAS
# Type Actions PubMed Ids Sitagliptin MK-0431 (see all 3 ) 486460-32-6 target inhibitor 16868220 19065993 17593236 18182122 16338283 17315049 17352516 11752352 17407649 16855072 16490580 16682937 (2s)-Pyrrolidin-2-Ylmethylamine -- -- target -- 17139284 17016423 10592235 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One -- -- target -- 17139284 17016423 10592235 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine -- -- target -- 17139284 17016423 10592235 Alpha-D-Mannose -- 3458-28-4 target -- 17139284 17016423 10592235 Vildagliptin EQUA (see all 8 ) 274901-16-5 target inhibitor 19149538 8100523 15562200 Diisopropylphosphono Group -- -- target -- 17139284 17016423 (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE -- -- target -- 10592235 (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE -- -- target -- 10592235 (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE -- -- target -- 10592235
10/81 Novoseek chemical compound relationships for DPP4 gene (see all 81 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
vildagliptin
96.9
109
15907807 (4), 17456545 (4), 17559747 (2), 17486328 (2) (see all 69 )
sitagliptin
96.5
123
16338283 (4), 18174966 (3), 16855072 (3), 17315049 (3) (see all 78 )
incretin
95.9
198
12517256 (3), 16939389 (3), 18979908 (3), 19780719 (3) (see all 99 )
saxagliptin
92.2
25
19051153 (4), 20460554 (2), 19444391 (2), 16364232 (2) (see all 17 )
exenatide
91.1
44
19421968 (2), 18363534 (1), 16724926 (1), 17566392 (1) (see all 30 )
liraglutide
89.7
22
17566392 (1), 19170358 (1), 19330494 (1), 20298625 (1) (see all 16 )
metformin
84.3
43
15842525 (5), 17559747 (2), 17300594 (2), 16043735 (1) (see all 28 )
pro-boropro
79.6
4
7918465 (1), 7892748 (1), 8103356 (1)
(2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
73.3
4
15634008 (2), 16338283 (1)
pramlintide
71.3
5
16215105 (1), 17983555 (1), 16627399 (1), 18035865 (1) (see all 5 )
DPP4
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Transcriptsfor DPP4 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DPP4 gene: NM_001935.3 Unigene Cluster for DPP4:
Dipeptidyl-peptidase 4 Hs.368912 [show with all ESTs ] Unigene Representative Sequence: NM_001935 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000360534 (uc002ubz.3 uc010fpb.3 ) ENST00000434918 ENST00000491591 ENST00000490286 ENST00000494507 ENST00000468903 ENST00000416189 ENST00000497461 (uc002uca.1 uc002ucb.1 )ENST00000461836 ENST00000413651 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DPP4 (NM_001935 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPP4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DPP4
Additional cDNA sequence: AB451339.1 AB451488.1 AK314798.1 AY429531.1 AY429532.1 AY429533.1 BC013329.2 BC065265.1 M74777.1 M80536.1 X60708.1
10 DOTS entries : DT.91801581 DT.95158537
DT.100790607 DT.91744488 DT.121006132 DT.121006110 DT.75167565 DT.100689591 DT.121006125 DT.91744489 24/277 AceView cDNA sequences (see all 277 ):
BE885391 AA931228 BX481638 CR618494 AA156117 AY429531 AA613759 CA975959 CB265788 CA446944 AL544456 CR612763 BC013329 AI498672 BC065265 BM831045 NM_001935 BQ427580 AI091652 AU105699 BP334262 AW299669 AA031955 AA854837 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DPP4 (see all 12 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ SP1 : - - - - - SP2 : - - - SP3 : - - - - SP4 : - - - SP5 :
ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 SP1 : - SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for DPP4
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Expression for DPP4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DPP4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTGGGAACCAbout this image DPP4 expression in embryonic tissues and stem cells About this table
See DPP4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DPP4 SOURCE GeneReport for Unigene cluster: Hs.368912 UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487 Tissue specificity : Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine,esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon SABiosciences Expression via Pathway-Focused PCR Arrays including DPP4 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP4
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Orthologsfor DPP4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for DPP4 gene from 6/23 species (see all 23 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves DPP41
dipeptidyl-peptidase 4
68.03(n) 65.08(a)
424187 NM_001031255.1 NP_001026426.1
lizard Reptilia DPP46
--
63(a)
1 ↔ 1
GL343359.1(634053-711896)
African clawed frog Amphibia LOC3978882
dipeptidyl-peptidase IV
75.6(n)
Y08932.1
zebrafish Actinopterygii dpp41
dipeptidyl-peptidase 4
61.09(n) 57.96(a)
100301982 NM_001161337.1 NP_001154809.1
fruit fly Insecta CG113193 1
dipeptidyl-peptidase IV3 1
33(a) 3 45.77(n) 1 36.75(a) 1
33810 1 NM_135117.2 1 NP_608961.2 1
worm Secernentea C27C12.73
dipeptidyl aminopeptidase like
30(a)
X(14867078-14873371) --
ENSEMBL Gene Tree for DPP4 (if available)TreeFam Gene Tree for DPP4 (if available)
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Paralogsfor DPP4 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DPP4 gene DPP8 2 FAP 2 DPP10 2 DPP6 2 DPP9 2 3 SIMAP similar genes for DPP4 using alignment to 4 protein entries: DPP4_HUMAN (see all proteins ):FAP DPP10 DPP6 About GeneDecksing
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Genomic Variantsfor DPP4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 2 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for DPP4 (162848751 - 162931052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DPP4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor DPP4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 102720
OMIM disorders : --20/124 (see all 124 ): About MalaCards simpson-golabi-behmel syndrome maturity-onset diabetes of the young severe combined immunodeficiency mycosis fungoides glucose intolerance non-small cell lung carcinoma short bowel syndrome pre-eclampsia anaplastic large cell lymphoma anorexia nervosa clear cell renal cell carcinoma non-hodgkin lymphoma combined immunodeficiency type 2 diabetes mellitus eating disorder inflammatory bowel disease arc syndrome bulimia nervosa primary biliary cirrhosis lupus erythematosus 4 diseases from the University of Copenhagen DISEASES database for DPP4 :Diabetes mellitus Hypoglycemia Hyperglycemia Nasopharyngitis 10/95 Novoseek disease relationships for DPP4 gene (see all 95 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
hypoglycemia
80.1
18
18641927 (1), 19444259 (1), 19820277 (1), 19170358 (1) (see all 17 )
niddm
75.3
69
18019673 (3), 18425967 (2), 16503716 (2), 17190843 (2) (see all 55 )
hyperglycemia
57.2
11
15864535 (3), 16939389 (1), 17160910 (1), 18035865 (1) (see all 8 )
sezary syndrome
49.5
2
11392886 (1), 16197392 (1)
insulin resistance
47.5
4
19333209 (1), 12524666 (1), 15934925 (1)
nasopharyngitis
42.7
1
17622601 (1)
goiter adenomatous
38.3
1
7591305 (1)
hyperinsulinemia
36.6
6
18319497 (1), 18812476 (1), 15770466 (1), 19128990 (1)
impaired glucose tolerance
35.1
6
12808880 (2), 9792533 (1), 15330741 (1), 12524666 (1)
colon adenocarcinoma
31.7
4
1968064 (1), 7903248 (1), 11772392 (1)
Genetic Association Database (GAD): DPP4 Human Genome Epidemiology (HuGE) Navigator: DPP4 (8 documents) Export disorders for DPP4 gene to outside databases
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Publicationsfor DPP4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DPP4 gene, integrated from 9 sources (see all 1101 ):(articles sorted by number of sources associating them with DPP4) Utopia : connect your pdf to the dynamic
Direct association of adenosine deaminase with a T cell activation antigen, CD26. (PubMed id 8101391) 1 , 2 , 3, 9(1993) Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation. (PubMed id 10900005) 1 , 2 , 9(2000) N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding. (PubMed id 14691230) 1 , 2 , 9(2004) Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. (PubMed id 17287217) 1 , 2 , 9(2007) A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase. (PubMed id 8096237) 1 , 2 , 9(1993) Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation. (PubMed id 1347043) 1 , 2 , 9(1992) Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction. (PubMed id 11772392) 1 , 2 , 9(2002) The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices. (PubMed id 16651416) 1 , 2 , 9(2006) Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains. (PubMed id 11773049) 1 , 2 , 9(2002) Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon. (PubMed id 1677636) 1 , 2 , 9(1991)
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External Searches for DPP4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DPP4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DPP4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DPP4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DPP4 gene: DPP4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DPP4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for DPP4 OriGene shRNA RFP for DPP4 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for DPP4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DPP4 OriGene 3'-UTR Clone for DPP4 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for DPP4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DPP4 OriGene Custom Protein Services for DPP4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPP4 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Tocris compounds for DPP4
Recombinant Protein for DPP4
DPP4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP4
ThermoFisher Antibody for DPP4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DPP4
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summary
for 
and Proteopedia 
for DPP4 (
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
In-situ hybridization
