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DPP4 Gene

protein-coding GIFtS: 72

GC02M162557

dipeptidyl-peptidase 4
(Previous names: dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), adenosine deaminase complexing protein 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CD26, ADCP2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADABP ^², ³
ADCP2 ^², ³, ⁵
CD26 ^², ³, ⁵
DPPIV ^¹, ²
EC 3.4.14.5 ^³
TP103 ^², ³

Descriptions
Adenosine deaminase complexing protein 2 ^¹, ², ³
CD26 antigen ^³
DPP IV ^³
Dipeptidyl peptidase IV ^³
T-cell activation antigen CD26 ^², ³
dipeptidyl-peptidase 4 ^²
dipeptidylpeptidase 4 ^²
dipeptidylpeptidase IV ^²
dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) ^¹, ²

External Ids
HGNC: 3009¹
Entrez Gene: 1803²
UniProtKB: P27487³
Ensembl: ENSG00000197635⁷

Search outside databases for aliases for DPP4 gene

Previous GC identifers: GC02M160902 GC02M161376 GC02M162812 GC02M163051 GC02M162674

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DPP4:

The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to

the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine

exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by

RefSeq]

UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487

Function: Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted

N-termini provided that the penultimate residue is proline. Plays a role in T-cell activation

Gene Wiki entry for DPP4 (Dipeptidyl_peptidase-4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DPP4 gene

Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q23-qter

DPP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M162557: (about GC identifiers)

Start:	162,557,001 bp from pter
End:	162,639,298 bp from pter
Size:	82,298 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487 (See protein sequence)

Recommended Name: Dipeptidyl peptidase 4

Size: 766 amino acids; 88279 Da

Subunit: Homodimer or heterodimer with Seprase (FAP)

Subcellular location: Dipeptidyl peptidase 4 soluble form: Secreted

Subcellular location: Cell membrane; Single-pass type II membrane protein

PDB structures from and Proteopedia :

1J2E (3D)

1N1M (3D)

1NU6 (3D)

1NU8 (3D)

1PFQ (3D)

1R9M (3D)

1R9N (3D)

1RWQ (3D)

1TK3 (3D)

1TKR (3D)

1U8E (3D)

1W1I (3D)

1WCY (3D)

1X70 (3D)

2AJL (3D)

2BGN (3D)

2BGR (3D)

2BUB (3D)

2FJP (3D)

2G5P (3D)

2G5T (3D)

2G63 (3D)

2HHA (3D)

2I03 (3D)

2I78 (3D)

2IIT (3D)

2IIV (3D)

2JID (3D)

2OAG (3D)

2OGZ (3D)

2OLE (3D)

2ONC (3D)

2OPH (3D)

2OQI (3D)

2OQV (3D)

2P8S (3D)

2QJR (3D)

2QKY (3D)

2QOE (3D)

2QT9 (3D)

2QTB (3D)

2RGU (3D)

2RIP (3D)

3BJM (3D)

3C43 (3D)

3C45 (3D)

3CCB (3D)

3CCC (3D)

3D4L (3D)

3EIO (3D)

Post-translational modifications:

The soluble form (SDPP) derives from the membrane form (MDPP) by proteolytic processing¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001926.2

ENSEMBL proteins:

ENSP00000353731

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant DPP4 Protein
	Sigma-Aldrich Proteins and CompoZr ZFN for DPP4
	R&D Systems Recombinant & Natural Proteins for DPP4 (DPPIV/CD26)
	Enzo Life Sciences proteins for DPP4
	Recombinant Proteins from Abcam (CD26)
	Human Recombinant Proteins from Abnova (DPP4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IDA	16670267
GO:0009986	cell surface	IDA	7594462 11772392
GO:0016021	integral to membrane	IEA	--
GO:0046581	intercellular canaliculus	IEA	--

About this table

Antibodies for DPP4:

	Invitrogen Antibodies for DPP4
	Millipore Mono- and Polyclonal Antibodies for the study of DPP4
	Sigma-Aldrich Antibodies for DPP4
	R&D Systems Antibodies for DPP4 (DPPIV/CD26)
	Antibodies from Abcam (CD26), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DPP4)
	Novus Biologicals Antibodies for DPP4

Assays for DPP4:

	Invitrogen Assays for DPP4
	Millipore Kits and Assays for the Analysis of DPP4
	R&D Systems ELISAs for DPP4 (DPPIV/CD26) (see all)
	Enzo Life Sciences assays for DPP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P27487

ProtoNet protein and cluster: P27487

2 Blocks protein families:

IPB002469 Dipeptidylpeptidase IV (CD26)

IPB002471 Prolyl endopeptidase

UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487

Similarity: Belongs to the peptidase S9B family. DPPIV subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DPP4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DPP4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001935

Applied Biosystems Silencer® siRNAs for DPP4

Sigma-Aldrich siRNA and siRNA Panels for DPP4

Sigma-Aldrich shRNA for DPP4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DPP4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001935
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001935
untagged cDNA clone in CMV expression vector: NM_001935

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001935

UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487

Function: Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted

N-termini provided that the penultimate residue is proline. Plays a role in T-cell activation

Catalytic activity: Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide,

preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline

Enzyme Number (IUBMB): EC 3.4.14.5

Genatlas biochemistry entry for DPP4:

peptidase,dipeptidyl IV (intestinal),regulated by hepatocyte nuclear factor 1 alpha

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dpp4):

digestive/alimentary

endocrine/exocrine gland

growth/size

homeostasis/metabolism

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004177	aminopeptidase activity	IEA	--
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	7594462 14684150
GO:0008233	peptidase activity	IEA	--
GO:0008239	dipeptidyl-peptidase activity	IDA	14684150

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for DPP4

5/57 Interacting proteins for DPP4 (ENSP00000353731³ P27487²) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CXCL12	P48061²	STRING (score=.962) MINT-6491448 MINT-6491442
CCL11	P51671²	STRING (score=.939) MINT-6491527
CXCL10	P02778²	STRING (score=.882) MINT-6491454
CXCL11	O14625²	STRING (score=.926) MINT-6491460
CXCL9	Q07325²	STRING (score=.876) MINT-6491519

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	16670267
GO:0006508	proteolysis	IEA	--
GO:0033632	regulation of cell-cell adhesion mediated by integrin	IDA	11772392
GO:0042110	T cell activation	IDA	7594462

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for DPP4

Sigma-Aldrich Small Molecules for DPP4:

Inhibitor

Compounds for DPP4 available from Tocris Bioscience

Compound	Action	CAS number
K 579	Dipeptidyl peptidase IV (DPP-IV) inhibitor	[440100-64-1]
NVP DPP 728 dihydrochloride	Potent, orally active DPP-IV inhibitor	[247016-69-9]
DPPI 1c hydrochloride	Dipeptidyl peptidase IV (DPP-IV) inhibitor	[866396-34-1]

About this table

10/41 Novoseek chemical compound relationships for DPP4 gene (see all 41 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
vildagliptin	96.59	97	15907807 (4), 17456545 (4), 17559747 (2), 17486328 (2) (see all 59)
incretin	95.55	175	12517256 (3), 16939389 (3), 18979908 (3), 16800760 (3) (see all 99)
saxagliptin	90.14	13	19051153 (4), 16364232 (2), 16318402 (1), 16257208 (1) (see all 7)
liraglutide	89.41	16	17566392 (1), 19170358 (1), 19330494 (1), 12975025 (1) (see all 11)
pro-boropro	80.43	4	7918465 (1), 7892748 (1), 8103356 (1)
(2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine	74.30	4	15634008 (2), 16338283 (1)
pyrazolidine	68.76	6	15713382 (2), 15893294 (2), 16079547 (2)
glucose	67.83	174	18671716 (7), 12524666 (5), 17944883 (4), 11394909 (3) (see all 88)
n-phenylphthalimide	66.33	3	10445048 (1), 10098663 (1)
proline	63.47	56	15853709 (2), 9622551 (2), 7911611 (2), 1671823 (2) (see all 31)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DPP4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DPP4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001935

Sigma-Aldrich siRNA and siRNA Panels for DPP4

Sigma-Aldrich shRNA for DPP4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001935

REFSEQ mRNAs for DPP4 gene:

NM_001935.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001935

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001935
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001935
                                 untagged cDNA clone in CMV expression vector: NM_001935

Additional cDNA sequence:

AB451339.1 AB451488.1 AK314798.1 AY429531.1 AY429532.1 AY429533.1 BC013329.2 BC065265.1

CR612763.1 CR618494.1 M74777.1 M80536.1 X60708.1

10 DOTS entries:

DT.91801581 DT.95158537 DT.100790607 DT.91744488 DT.121006132 DT.121006110 DT.75167565 DT.100689591

DT.121006125 DT.91744489

24/277 AceView cDNA sequences (see all 277 ):

AI803020 BX110831 AY429533 AL708589 AA854837 BP334755 BQ021261 AA031955

AW452150 AA613759 AU105699 NM_001935 BP334262 BP343342 AW299669 CB265788

BQ019734 AY429531 BM831045 AU105696 BX381370 AI498672 AI768728 AA156117

highest scoring ESTs for DPP4:

X60708 AL708575 AL708589 AL712620 AU099438 BC065265 BF673268 BG399222 BG573012 BQ427580

Unigene Cluster for DPP4:

Dipeptidyl-peptidase 4

Hs.368912 [show with all ESTs]

Unigene Representative Sequence: NM_001935

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DPP4 (see all 12 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^
SP1:															-				-		-																		-								-
SP2:																			-		-																		-
SP3:			-												-				-		-
SP4:															-				-		-
SP5:

ExUns:	19	^	20	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31
SP1:					-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DPP4

1 Ensembl transcript including schematic representation:

ENST00000360534

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DPP4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DPP4

¹ / ² / ³

7 probe-sets matching DPP4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34823_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X60708	1.00	1.00	1.00	1
203717_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001935	0.60	1.00	0.82	1
203716_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M80536	0.60	1.00	0.82	1
211478_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M74777	0.80	1.00	0.91	1
203717_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203716_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211478_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DPP4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGGGAACC

SOURCE GeneReport for Unigene cluster: Hs.368912
Expression variation in blood from EXPOLDB for DPP4
UniProtKB/Swiss-Prot: DPP4_HUMAN, P27487
Tissue specificity: Expressed in the poorly differentiated crypt cells of the small intestine as
well as in the mature villous cells. Expressed at very low levels in the colon

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DPP4 gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DPP4¹	--	dipeptidyl-peptidase 4	90.21(n) 88.66(a)	478767 XM_535933.2 XP_535933.2
chimpanzee (Pan troglodytes)	DPP4¹	--	dipeptidyl-peptidase 4	99.61(n) 99.61(a)	459689 XM_515858.2 XP_515858.2
cow (Bos taurus)	DPP4¹	--	dipeptidyl-peptidase 4	90.05(n) 88.87(a)	281122 NM_174039.2 NP_776464.1
rat (Rattus norvegicus)	Dpp4¹	--	dipeptidylpeptidase 4	85.71(n) 85.19(a)	25253 NM_012789.1 NP_036921.1
mouse (Mus musculus)	Dpp4^{1, 5}	2 (35.00 cM)⁵	dipeptidylpeptidase 4^{1, 5}	86.65(n)¹ 85.24(a)¹	13482¹ NM_010074.2¹ NP_034204.1¹ AK040409⁵ AK085370⁵ (see all 36)

About this table Species with no ortholog for DPP4

ENSEMBL Gene Tree for DPP4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DPP4 gene

FAP²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/339 NCBI SNPs in DPP4 are shown (see all 339 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 120)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs12617336^1,2	C,F,H	162557558(+)	`AGCCTG/CCTCGT`	1	--	ut3¹		8	EU EA WA	838
	rs16846222^1,2	F,H	162557972(+)	`CAGTGC/TAGTTT`	1	--	ut3¹		7	NA EU EA WA	558
	rs6709308^1,2	F,H	162640541(+)	`tgagaC/Tgcaaa`	1	--	ng3¹		4	EU EA WA	418
	rs6709208^1,2	F,H	162640500(+)	`atctaC/Tgggac`	1	--	ng3¹		4	EU EA WA	418
	rs13821^1,2	F	162557793(-)	`TTTCTG/TCATCA`	1	--	ut3¹ ese³		1	MN	184
--	rs2302872^1,2	C,F,H	162585014(+)	`ATCCCG/AATGAC`	1	I/I	syn¹		4	EU EA WA	418
	rs2268890^1,2	A,C,F,H,O	162580738(-)	`TGGGAC/TCTTAT`	1	--	int¹		7	NA EU EA WA	558
	rs759717^1,2	A,C,F,H,O	162566569(+)	`TTGCAG/CAAAAG`	1	--	int¹		19	EA NA EU WA	1494
	rs2970933^1,2	A,C,F,H,O	162562522(-)	`TACGCG/AAATAT`	1	--	int¹		11	EU EA WA NA	948
	rs2111850^1,2	A,C,F,H,O	162599525(+)	`TTAACC/TAGTAA`	1	--	int¹		4	EU EA WA	410

About this table

HapMap Linkage Disequilibrium images for DPP4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 102720

10/94 Novoseek disease relationships for DPP4 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypoglycemia	75.51	11	18641927 (1), 19444259 (1), 19170358 (1), 11394909 (1) (see all 10)
niddm	69.13	51	18019673 (3), 18425967 (2), 16503716 (2), 17190843 (2) (see all 38)
sezary syndrome	50.81	2	11392886 (1), 16197392 (1)
hyperglycemia	47.69	8	15864535 (3), 16939389 (1), 17160910 (1), 15143860 (1) (see all 5)
insulin resistance	42.27	4	19333209 (1), 12524666 (1), 15934925 (1)
goiter adenomatous	40.19	1	7591305 (1)
nasopharyngitis	34.79	1	17622601 (1)
colon adenocarcinoma	34.10	4	1968064 (1), 7903248 (1), 11772392 (1)
adenoma follicular	33.48	5	14718282 (3), 7591305 (1), 18212751 (1)
mycosis fungoides	31.85	4	11392886 (1), 16197392 (1), 8541553 (1), 18089499 (1)

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Genetic Association Database: DPP4
Human Genome Epidemiology Navigator: DPP4 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/833 PubMed articles for DPP4 gene (see all 833 ):

A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase. (PubMed id 8096237)^{1, 3, 4} Morrison M.E....Houghton A.N. (1993)
Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation. (PubMed id 1347043)^{1, 3, 4} Darmoul D....Barbat A. (1992)
Direct association of adenosine deaminase with a T cell activation antigen, CD26. (PubMed id 8101391)^{1, 2, 3} Kameoka J....Morimoto C. (1993)
Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon. (PubMed id 1677636)^{1, 3, 4} Gorvel J.P....Maroux S. (1991)
The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold. (PubMed id 12646248)^{1, 3, 4} Hiramatsu H.... Shimizu R. (2003)
Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene. (PubMed id 7927537)^{1, 3, 4} Abbott C.A.... McCaughan G.W. (1994)
Cloning and functional expression of the T cell activation antigen CD26. (PubMed id 1352530)^{1, 3, 4} Tanaka T.... Morimoto C. (1992)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Large-scale investigation of genomic markers for severe periodontitis. (PubMed id 15490304)^{3, 6} Suzuki A....Kamoi K. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1803	HGNC: 3009	AceView: DPP4	Ensembl:ENSG00000197635	euGenes: HUgn1803
ECgene: DPP4	H-InvDB: DPP4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DPP4	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Dipeptidyl_peptidase-4

Licensable Technologies for DPP4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DPP4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DPP4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DPP4		Antibodies for DPP4
	Explore super-pooled esiRNAs		Proteins for DPP4
	Lentivirus-delivered shRNAs for DPP4		Small molecules for DPP4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DPP4)
	Antibodies (DPP4)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (CD26)
	Antibodies (CD26)

Search OriGene for DPP4

Tocris compounds for DPP4

	Assays/Drugs/Proteins for DPP4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DPP4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
DPP4 Gene at Home site.
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DPP4 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for DPP4

Summaries
for DPP4

Genomic Location
for DPP4

Proteins
for DPP4

Protein Domains/
Families
for DPP4

Gene Function
for DPP4

Pathways & Interactions
for DPP4

Drugs & Compounds
for DPP4

Transcripts
for DPP4

Expression
for DPP4

Orthologs
for DPP4

Paralogs
for DPP4

SNPs/Variants
for DPP4

Disorders & Mutations
for DPP4

Medical News
for DPP4

Publications
for DPP4

Search for DPP4

Genome Databases showing DPP4

Other Databases showing DPP4

Specialized Databases showing DPP4

Licensable Technologies
for DPP4

Services
for DPP4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DPP4 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor DPP4

Summariesfor DPP4

Genomic Locationfor DPP4

Proteinsfor DPP4

Protein Domains/Familiesfor DPP4

Gene Functionfor DPP4

Pathways & Interactionsfor DPP4

Drugs & Compoundsfor DPP4

Transcriptsfor DPP4

Expression for DPP4

Orthologsfor DPP4

Paralogsfor DPP4

SNPs/Variantsfor DPP4

Disorders & Mutationsfor DPP4

Medical Newsfor DPP4

Publicationsfor DPP4

Search for DPP4

Genome Databases showing DPP4

Other Databases showing DPP4

Specialized Databases showing DPP4

Licensable Technologiesfor DPP4

Servicesfor DPP4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DPP4

Summaries
for DPP4

Genomic Location
for DPP4

Proteins
for DPP4

Protein Domains/
Families
for DPP4

Gene Function
for DPP4

Pathways & Interactions
for DPP4

Drugs & Compounds
for DPP4

Transcripts
for DPP4

Expression
for DPP4

Orthologs
for DPP4

Paralogs
for DPP4

SNPs/Variants
for DPP4

Disorders & Mutations
for DPP4

Medical News
for DPP4

Publications
for DPP4

Licensable Technologies
for DPP4

Services
for DPP4