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Aliases for DPP4 Gene

Aliases for DPP4 Gene

  • Dipeptidyl-Peptidase 4 2 3
  • Adenosine Deaminase Complexing Protein 2 2 3 4
  • Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2) 2 3
  • T-Cell Activation Antigen CD26 3 4
  • Dipeptidyl Peptidase IV 3 4
  • EC 3.4.14.5 4 64
  • DPP IV 3 4
  • ADCP-2 3 4
  • ADCP2 3 4
  • ADABP 3 4
  • TP103 3 4
  • CD26 3 4
  • Adenosine Deaminase Complexing Protein-2) 6
  • Dipeptidyl Peptidase 4 3
  • Dipeptidylpeptidase 4 3
  • CD26 Antigen 4
  • DPPIV 3

External Ids for DPP4 Gene

Previous Symbols for DPP4 Gene

  • CD26
  • ADCP2

Summaries for DPP4 Gene

Entrez Gene Summary for DPP4 Gene

  • The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP4 Gene

DPP4 (Dipeptidyl-Peptidase 4) is a Protein Coding gene. Diseases associated with DPP4 include hepatosplenic t-cell lymphoma and mental depression. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Peptide hormone metabolism. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot for DPP4 Gene

  • Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Tocris Summary for DPP4 Gene

  • Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has roles in nutrition, metabolism, the immune and endocrine systems, bone marrow mobilization, cancer growth and cell adhesion. DDP-IV catalyzes the hydrolysis of N-terminal dipeptides from polypeptides with proline or alanine in the penultimate position. This enzyme has many natural substrates including GLP-1, GIP, PACAP 38, NPY and GRP. DPP-IV exists as a homodimer and each monomer consists of two domains; an alpha/beta hydrolase domain and an eight-blade beta-propeller domain. DDP-IV binds to, but does not cleave, adenosine deaminase, kidney Na+/H+ ion exchanger and fibronectin, which localizes these molecules to the cell surface. A soluble form of DDP-IV does also exist, although it is only known to function in relation to T-cell proliferation. The human gene encoding DPP-IV is localized to chromosome 2q24.2.

Gene Wiki entry for DPP4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP4 Gene

Genomics for DPP4 Gene

Genomic Location for DPP4 Gene

Start:
161,992,241 bp from pter
End:
162,074,542 bp from pter
Size:
82,302 bases
Orientation:
Minus strand

Genomic View for DPP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP4 Gene

Regulatory Elements for DPP4 Gene

Transcription factor binding sites by QIAGEN in the DPP4 gene promoter:

Proteins for DPP4 Gene

  • Protein details for DPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27487-DPP4_HUMAN
    Recommended name:
    Dipeptidyl peptidase 4
    Protein Accession:
    P27487
    Secondary Accessions:
    • Q53TN1

    Protein attributes for DPP4 Gene

    Size:
    766 amino acids
    Molecular mass:
    88279 Da
    Quaternary structure:
    • Monomer. Homodimer or heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3. Interacts with human coronavirus-EMC spike protein and acts as a receptor for this virus.
    Miscellaneous:
    • Level of plasma concentrations of the soluble form (SDPP) can be managed as a colon carcinoma diagnostic and prognostic marker

    Three dimensional structures from OCA and Proteopedia for DPP4 Gene

neXtProt entry for DPP4 Gene

Proteomics data for DPP4 Gene at MOPED

Post-translational modifications for DPP4 Gene

  • N- and O-Glycosylated.
  • Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.
  • The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn85, Asn92, Asn150, Asn219, Asn229, Asn281, Asn321, Asn520, and Asn685

Other Protein References for DPP4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DPP4 Gene

Gene Families for DPP4 Gene

HGNC:
  • CD :CD molecules
IUPHAR :

UniProtKB/Swiss-Prot:

DPP4_HUMAN
Domain:
  • The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity:
    • P27487
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.:
    • P27487
genes like me logo Genes that share domains with DPP4: view

Function for DPP4 Gene

Molecular function for DPP4 Gene

GENATLAS Biochemistry: peptidase,dipeptidyl IV (intestinal),regulated by hepatocyte nuclear factor 1 alpha
UniProtKB/Swiss-Prot CatalyticActivity: Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by GPC3 and diprotin A.
UniProtKB/Swiss-Prot Function: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
UniProtKB/Swiss-Prot Induction: Up-regulated by IL12/interleukin-12 on activated T-cells. IL12-activated cells expressed enhanced levels of DPP4 but not mRNAs. Down-regulated by TNF. Up-regulated in migratory endothelial cells and in the invasive endothelial cells in tumors.

Enzyme Numbers (IUBMB) for DPP4 Gene

Gene Ontology (GO) - Molecular Function for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 23486063
GO:0002020 protease binding IPI 16651416
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005102 receptor binding IPI 10900005
GO:0005515 protein binding IPI 14684150
genes like me logo Genes that share ontologies with DPP4: view
genes like me logo Genes that share phenotypes with DPP4: view

Animal Models for DPP4 Gene

MGI Knock Outs for DPP4:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for DPP4 Gene

Localization for DPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP4 Gene

Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid.
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction. Membrane raft. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPP4 Gene COMPARTMENTS Subcellular localization image for DPP4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 2
cytoskeleton 1
endosome 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane IDA 16670267
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IDA 10900005
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DPP4: view

Pathways for DPP4 Gene

genes like me logo Genes that share pathways with DPP4: view

Gene Ontology (GO) - Biological Process for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 16670267
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion --
GO:0008284 positive regulation of cell proliferation IDA 17549790
GO:0010716 negative regulation of extracellular matrix disassembly IDA 16651416
genes like me logo Genes that share ontologies with DPP4: view

Compounds for DPP4 Gene

(10) ApexBio Compounds for DPP4 Gene

Compound Action Cas Number
Alogliptin (SYR-322) novel, orally-available and highly selective quinazolinone-based inhibitor of DPP-4. [850649-61-5]
Alogliptin Benzoate orally administered, anti-diabetic drug in the DPP-4 inhibitor class. [850649-62-6]
Glimepiride increases the release of insulin from pancreatic beta cells. [93479-97-1]
K 579 DPP-4 inhibitor [440100-64-1]
Linagliptin (BI-1356) DPP-4 inhibitor [668270-12-0]
NVP DPP 728 dihydrochloride Potent, orally active DPP-4 inhibitor. [247016-69-9]
PK 44 phosphate Potent inhibitor of DPP-4. [1017682-65-3]
Saxagliptin (BMS-477118) new DPP-4 inhibitor [361442-04-8]
Trelagliptin Long acting DPP-4 inhibitor. [865759-25-7]
Vildagliptin (LAF-237) DPP-4 inhibitor [274901-16-5]

(4) Tocris Compounds for DPP4 Gene

Compound Action Cas Number
DPPI 1c hydrochloride Dipeptidyl peptidase IV (DPP-IV) inhibitor [866396-34-1]
K 579 Dipeptidyl peptidase IV (DPP-IV) inhibitor [440100-64-1]
NVP DPP 728 dihydrochloride Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor [247016-69-9]
PK 44 phosphate Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor [1017682-65-3]

(1) HMDB Compounds for DPP4 Gene

Compound Synonyms Cas Number PubMed IDs
Hydroxyproline
  • (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid
51-35-4

(81) Novoseek inferred chemical compound relationships for DPP4 Gene

Compound -log(P) Hits PubMed IDs
vildagliptin 96.9 82
sitagliptin 96.5 102
incretin 95.9 124
saxagliptin 92.2 23
exenatide 91.1 31
genes like me logo Genes that share compounds with DPP4: view

Transcripts for DPP4 Gene

Unigene Clusters for DPP4 Gene

Dipeptidyl-peptidase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPP4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7: - - - -
SP8:
SP9: - - -
SP10:
SP11: -
SP12: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DPP4 Gene

GeneLoc Exon Structure for
DPP4
ECgene alternative splicing isoforms for
DPP4

Expression for DPP4 Gene

mRNA expression in normal human tissues for DPP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPP4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (5.8), Kidney - Cortex (4.6), and Prostate (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPP4 Gene

SOURCE GeneReport for Unigene cluster for DPP4 Gene Hs.368912

mRNA Expression by UniProt/SwissProt for DPP4 Gene

P27487-DPP4_HUMAN
Tissue specificity: Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
genes like me logo Genes that share expressions with DPP4: view

Orthologs for DPP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP4 36
  • 99.61 (n)
  • 99.61 (a)
DPP4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 84 (a)
OneToMany
DPP4 37
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DPP4 36
  • 90.53 (n)
  • 88.92 (a)
DPP4 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp4 36
  • 86.65 (n)
  • 85.24 (a)
Dpp4 16
Dpp4 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP4 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPP4 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpp4 36
  • 85.71 (n)
  • 85.19 (a)
chicken
(Gallus gallus)
Aves DPP4 36
  • 68.12 (n)
  • 65.08 (a)
DPP4 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP4 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397888 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp4 36
  • 62.84 (n)
  • 60.19 (a)
Str.19218 36
zebrafish
(Danio rerio)
Actinopterygii dpp4 36
  • 61.23 (n)
  • 57.95 (a)
dpp4 37
  • 56 (a)
ManyToMany
fap 37
  • 53 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008176 36
  • 36.09 (n)
  • 24.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11034 36
  • 46.68 (n)
  • 37.45 (a)
CG11034 37
  • 34 (a)
ManyToMany
CG11319 37
  • 26 (a)
ManyToMany
CG9059 37
  • 23 (a)
ManyToMany
ome 37
  • 23 (a)
ManyToMany
CG11319 38
  • 33 (a)
CG9059 38
  • 29 (a)
CG11034 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea dpf-1 37
  • 24 (a)
ManyToMany
dpf-2 36
  • 43.08 (n)
  • 33.33 (a)
dpf-2 37
  • 24 (a)
ManyToMany
T23F1.7b 38
  • 29 (a)
C27C12.7 38
  • 30 (a)
T23F1.7a 38
  • 29 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR073C 36
  • 43.75 (n)
  • 34.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP2 36
  • 45.53 (n)
  • 34.89 (a)
DAP2 37
  • 29 (a)
ManyToMany
DAP2 39
STE13 37
  • 20 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11485g 36
  • 44.64 (n)
  • 33.05 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02515 36
  • 46.36 (n)
  • 34.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPACUNK4.08 36
  • 46.14 (n)
  • 32.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1344 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
Species with no ortholog for DPP4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP4 Gene

ENSEMBL:
Gene Tree for DPP4 (if available)
TreeFam:
Gene Tree for DPP4 (if available)

Paralogs for DPP4 Gene

Paralogs for DPP4 Gene

Selected SIMAP similar genes for DPP4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DPP4: view

Variants for DPP4 Gene

Sequence variations from dbSNP and Humsavar for DPP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13821 -- 161,993,037(-) TTTCT(G/T)CATCA utr-variant-3-prime
rs17574 -- 162,073,469(-) GTTCT(C/T)CTGGG synonymous-codon, reference
rs17575 -- 162,073,412(-) GTTCT(A/G)CTGAA synonymous-codon, reference
rs727204 -- 162,025,773(+) CTCTC(A/G)AGTGT intron-variant
rs738107 -- 162,026,600(+) ACCTC(C/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP4 Gene

Variant ID Type Subtype PubMed ID
nsv3008 CNV Insertion 18451855
nsv834439 CNV Gain 17160897

Relevant External Links for DPP4 Gene

HapMap Linkage Disequilibrium report
DPP4
Human Gene Mutation Database (HGMD)
DPP4

Disorders for DPP4 Gene

(4) University of Copenhagen DISEASES for DPP4 Gene

(95) Novoseek inferred disease relationships for DPP4 Gene

Disease -log(P) Hits PubMed IDs
hypoglycemia 80.1 17
niddm 75.3 60
hyperglycemia 57.2 10
sezary syndrome 49.5 2
insulin resistance 47.5 3

Relevant External Links for DPP4

Genetic Association Database (GAD)
DPP4
Human Genome Epidemiology (HuGE) Navigator
DPP4
genes like me logo Genes that share disorders with DPP4: view

No data available for UniProtKB/Swiss-Prot for DPP4 Gene

Publications for DPP4 Gene

  1. Cloning and functional expression of the T cell activation antigen CD26. (PMID: 1352530) Tanaka T. … Morimoto C. (J. Immunol. 1992) 3 4 23
  2. Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface. (PMID: 1352704) Misumi Y. … Ikehara Y. (Biochim. Biophys. Acta 1992) 3 4 23
  3. Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation. (PMID: 1347043) Darmoul D. … Barbat A. (J. Biol. Chem. 1992) 3 4 23
  4. A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase. (PMID: 8096237) Morrison M.E. … Houghton A.N. (J. Exp. Med. 1993) 3 4 23
  5. Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene. (PMID: 7927537) Abbott C.A. … McCaughan G.W. (Immunogenetics 1994) 3 4 23

Products for DPP4 Gene

Sources for DPP4 Gene

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