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Aliases for DPP4 Gene

Aliases for DPP4 Gene

  • Dipeptidyl Peptidase 4 2 3 5
  • Adenosine Deaminase Complexing Protein 2 2 3 4
  • Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2) 2 3
  • T-Cell Activation Antigen CD26 3 4
  • Dipeptidyl Peptidase IV 3 4
  • EC 3.4.14.5 4 61
  • DPP IV 3 4
  • ADCP-2 3 4
  • ADCP2 3 4
  • ADABP 3 4
  • TP103 3 4
  • CD26 3 4
  • Dipeptidyl-Peptidase 4 2
  • Dipeptidylpeptidase 4 3
  • CD26 Antigen 4
  • DPPIV 3

External Ids for DPP4 Gene

Previous HGNC Symbols for DPP4 Gene

  • CD26
  • ADCP2

Previous GeneCards Identifiers for DPP4 Gene

  • GC02M160902
  • GC02M161376
  • GC02M162812
  • GC02M163051
  • GC02M162674
  • GC02M162557
  • GC02M154730
  • GC02M162848

Summaries for DPP4 Gene

Entrez Gene Summary for DPP4 Gene

  • The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP4 Gene

DPP4 (Dipeptidyl Peptidase 4) is a Protein Coding gene. Diseases associated with DPP4 include Nasopharyngitis and Mental Depression. Among its related pathways are Collagen chain trimerization and Incretin synthesis, secretion, and inactivation. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot for DPP4 Gene

  • Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Tocris Summary for DPP4 Gene

  • Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has several roles including in nutrition, metabolism, bone marrow mobilization, cancer growth, cell adhesion and within both the immune and endocrine systems.

Gene Wiki entry for DPP4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP4 Gene

Genomics for DPP4 Gene

Regulatory Elements for DPP4 Gene

Enhancers for DPP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G162027 1.2 ENCODE dbSUPER 12.2 +46.7 46689 1.1 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 GTF3C2 FOS ENSG00000230918 DPP4 LOC101929512 AHCTF1P1 RPEP5
GH02G162112 1.2 Ensembl ENCODE 11.1 -39.3 -39264 2.5 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GATA2 FOS MXD4 TIMM8AP1 DPP4 LOC101929532 ENSG00000233397
GH02G161995 1.1 ENCODE dbSUPER 11.5 +78.7 78721 1.1 FOXA2 ATF1 MIXL1 THAP11 SP5 CEBPB PPARG MIER3 RAD51 KLF16 ENSG00000230918 DPP4 RPEP5
GH02G162063 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +4.5 4531 12.4 HNRNPUL1 PKNOX1 FOXA2 ATF1 SIN3A ARID4B DMAP1 ZNF48 YY1 CBX5 DPP4 TANK ENSG00000230918 RPEP5
GH02G162029 0.9 ENCODE dbSUPER 12.2 +44.7 44657 1.3 SIN3A CEBPB CEBPG HMG20A JUND FOS HNF4A RXRB TCF7L2 ENSG00000230918 DPP4 RPEP5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPP4 on UCSC Golden Path with GeneCards custom track

Promoters for DPP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125463 842 1401 HNRNPUL1 ARID4B DMAP1 ZNF48 YY1 CBX5 ZNF143 TBX21 MIER3 RCOR2

Transcription factor binding sites by QIAGEN in the DPP4 gene promoter:

Genomic Location for DPP4 Gene

Chromosome:
2
Start:
161,992,241 bp from pter
End:
162,074,542 bp from pter
Size:
82,302 bases
Orientation:
Minus strand

Genomic View for DPP4 Gene

Genes around DPP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP4 Gene

Proteins for DPP4 Gene

  • Protein details for DPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27487-DPP4_HUMAN
    Recommended name:
    Dipeptidyl peptidase 4
    Protein Accession:
    P27487
    Secondary Accessions:
    • Q53TN1

    Protein attributes for DPP4 Gene

    Size:
    766 amino acids
    Molecular mass:
    88279 Da
    Quaternary structure:
    • Monomer. Homodimer (PubMed:12832764, PubMed:15448155, PubMed:17287217, PubMed:12646248, PubMed:12483204, PubMed:12906826). Heterodimer with Seprase (FAP) (PubMed:16651416). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Associates with collagen (PubMed:8526932). Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959). Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity (PubMed:15016824, PubMed:10951221, PubMed:14691230, PubMed:7907293, PubMed:8101391). Interacts with CAV1 (via the N-terminus); the interaction is direct (PubMed:17287217). Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11 (PubMed:17287217). Interacts with IGF2R; the interaction is direct (PubMed:10900005). Interacts with GPC3 (PubMed:17549790). Interacts with human coronavirus-EMC spike protein and acts as a receptor for this virus (PubMed:23486063).
    Miscellaneous:
    • Level of plasma concentrations of the soluble form (SDPP) can be managed as a colon carcinoma diagnostic and prognostic marker.

    Three dimensional structures from OCA and Proteopedia for DPP4 Gene

neXtProt entry for DPP4 Gene

Selected DME Specific Peptides for DPP4 Gene

P27487:
  • VPLIEYSFYSDESLQYP
  • FDKSKKYP
  • IEALTSDYLYYISN
  • TFLAYAQFNDT
  • LRVLEDNSALDKMLQ
  • MWYTDEDHGIAS
  • GPGLPLYTLH
  • YDSVYTERYM
  • GDHYLCDV
  • RNLYKIQL
  • VYAGPCSQK
  • FNAEYGNSS

Post-translational modifications for DPP4 Gene

  • N- and O-Glycosylated.
  • Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.
  • The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
  • Glycosylation at isoforms=85, isoforms=92, Asn150, isoforms=219, isoforms=229, Asn281, isoforms=321, Asn520, and Asn685
  • Modification sites at PhosphoSitePlus

Other Protein References for DPP4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DPP4 (DPP4)

Protein Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for DPP4

Domains & Families for DPP4 Gene

Gene Families for DPP4 Gene

Suggested Antigen Peptide Sequences for DPP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27487

UniProtKB/Swiss-Prot:

DPP4_HUMAN :
  • The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity.
  • Belongs to the peptidase S9B family. DPPIV subfamily.
Domain:
  • The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity.
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.
genes like me logo Genes that share domains with DPP4: view

Function for DPP4 Gene

Molecular function for DPP4 Gene

GENATLAS Biochemistry:
peptidase,dipeptidyl IV (intestinal),regulated by hepatocyte nuclear factor 1 alpha
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by GPC3 and diprotin A.
UniProtKB/Swiss-Prot Function:
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL12/interleukin-12 on activated T-cells. IL12-activated cells expressed enhanced levels of DPP4 but not mRNAs. Down-regulated by TNF. Up-regulated in migratory endothelial cells and in the invasive endothelial cells in tumors. Induced by hypoxia (PubMed:16670267).

Enzyme Numbers (IUBMB) for DPP4 Gene

Gene Ontology (GO) - Molecular Function for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 23486063
GO:0002020 protease binding IPI 16651416
GO:0004177 aminopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity EXP 8100523
GO:0005102 receptor binding IPI 10900005
genes like me logo Genes that share ontologies with DPP4: view
genes like me logo Genes that share phenotypes with DPP4: view

Animal Models for DPP4 Gene

MGI Knock Outs for DPP4:

Animal Model Products

  • Taconic Biosciences Mouse Models for DPP4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DPP4

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPP4 Gene

Localization for DPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP4 Gene

Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid.
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction. Membrane raft. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269 PubMed:10900005, ECO:0000269 PubMed:11772392, ECO:0000269 PubMed:11773049, ECO:0000269 PubMed:12676959, ECO:0000269 PubMed:16651416, ECO:0000269 PubMed:17287217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
cytosol 3
golgi apparatus 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IDA 7594462
genes like me logo Genes that share ontologies with DPP4: view

Pathways & Interactions for DPP4 Gene

genes like me logo Genes that share pathways with DPP4: view

SIGNOR curated interactions for DPP4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0001666 response to hypoxia IDA 16670267
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0008284 positive regulation of cell proliferation IDA 17549790
genes like me logo Genes that share ontologies with DPP4: view

Drugs & Compounds for DPP4 Gene

(118) Drugs for DPP4 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Saxagliptin Approved Pharma inhibitor, Target Selective DPP4 inhibitor 127
Sitagliptin Approved, Investigational Pharma inhibitor, Target 0
Vildagliptin Approved, Investigational Pharma inhibitor, Target 157
Glimepiride Approved Pharma Sulfonylurea compound 234
Alogliptin Approved Pharma inhibitor, Target 60

(45) Additional Compounds for DPP4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4

(3) Tocris Compounds for DPP4 Gene

Compound Action Cas Number
DPPI 1c hydrochloride Dipeptidyl peptidase IV (DPP-IV) inhibitor 866396-70-5
K 579 Dipeptidyl peptidase IV (DPP-IV) inhibitor 440100-64-1
PK 44 phosphate Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor 1017682-66-4

(8) ApexBio Compounds for DPP4 Gene

Compound Action Cas Number
Alogliptin (SYR-322) DPP-4 inhibitor,potent and highly selective 850649-61-5
Glimepiride Sulfonylurea compound 93479-97-1
Linagliptin (BI-1356) DDP-4 inhibitor,highly potent and competitive 668270-12-0
NVP DPP 728 dihydrochloride DPP-IV inhibitor 247016-69-9
Saxagliptin Selective DPP4 inhibitor 361442-04-8
Sitagliptin phosphate monohydrate Potent DPP-4 inhibitor 654671-77-9
Trelagliptin DPP-4 inhibitor,long-acting and selective 865759-25-7
Vildagliptin (LAF-237) DPP-4 inhibitor 274901-16-5
genes like me logo Genes that share compounds with DPP4: view

Drug Products

Transcripts for DPP4 Gene

Unigene Clusters for DPP4 Gene

Dipeptidyl-peptidase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DPP4

Alternative Splicing Database (ASD) splice patterns (SP) for DPP4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7: - - - -
SP8:
SP9: - - -
SP10:
SP11: -
SP12: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DPP4 Gene

GeneLoc Exon Structure for
DPP4
ECgene alternative splicing isoforms for
DPP4

Expression for DPP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPP4 Gene

mRNA differential expression in normal tissues according to GTEx for DPP4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.8), Kidney - Cortex (x4.6), and Prostate (x4.1).

Protein differential expression in normal tissues from HIPED for DPP4 Gene

This gene is overexpressed in Serum (11.5), Pancreatic juice (10.3), Placenta (7.7), Urine (6.2), and Salivary gland (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of DPP4 Gene:

DPP4

SOURCE GeneReport for Unigene cluster for DPP4 Gene:

Hs.368912

mRNA Expression by UniProt/SwissProt for DPP4 Gene:

P27487-DPP4_HUMAN
Tissue specificity: Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.

Evidence on tissue expression from TISSUES for DPP4 Gene

  • Kidney(4.8)
  • Blood(4.6)
  • Intestine(4.6)
  • Liver(4.6)
  • Bone marrow(4.3)
  • Pancreas(3.4)
  • Heart(2.6)
  • Lung(2.4)
  • Muscle(2.3)
  • Skin(2.2)
  • Spleen(2.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with DPP4: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPP4 Gene

Orthologs for DPP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP4 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia DPP4 34 35
  • 90.53 (n)
mouse
(Mus musculus)
Mammalia Dpp4 34 16 35
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia Dpp4 34
  • 85.71 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 84 (a)
OneToMany
DPP4 35
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DPP4 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP4 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPP4 34 35
  • 68.12 (n)
lizard
(Anolis carolinensis)
Reptilia DPP4 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp4 34
  • 62.84 (n)
Str.19218 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397888 34
zebrafish
(Danio rerio)
Actinopterygii dpp4 34 35
  • 61.23 (n)
fap 35
  • 53 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11034 36 34 35
  • 46.68 (n)
CG11319 36 35
  • 33 (a)
CG9059 36 35
  • 29 (a)
ome 35
  • 23 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008176 34
  • 36.09 (n)
worm
(Caenorhabditis elegans)
Secernentea dpf-2 34 35
  • 43.08 (n)
C27C12.7 36
  • 30 (a)
T23F1.7a 36
  • 29 (a)
T23F1.7b 36
  • 29 (a)
dpf-1 35
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP2 34 35 37
  • 45.53 (n)
STE13 35
  • 20 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11485g 34
  • 44.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR073C 34
  • 43.75 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02515 34
  • 46.36 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPACUNK4.08 34
  • 46.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1344 34
Species where no ortholog for DPP4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP4 Gene

ENSEMBL:
Gene Tree for DPP4 (if available)
TreeFam:
Gene Tree for DPP4 (if available)

Paralogs for DPP4 Gene

Paralogs for DPP4 Gene

(3) SIMAP similar genes for DPP4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DPP4: view

Variants for DPP4 Gene

Sequence variations from dbSNP and Humsavar for DPP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000013870 -- 162,068,689(+) AAGTA(C/T)AATTT intron-variant
rs1000038446 -- 162,071,008(+) GTAGC(C/T)CTGGA intron-variant
rs1000053373 -- 162,022,906(+) TGAGA(A/G)CTATC intron-variant
rs1000063989 -- 162,031,450(+) TAAAG(-/C)CCCTT intron-variant
rs1000085499 -- 162,068,430(+) AAGTT(C/G)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP4 Gene

Variant ID Type Subtype PubMed ID
esv3429795 CNV insertion 20981092
nsv3008 CNV insertion 18451855
nsv834439 CNV gain 17160897

Variation tolerance for DPP4 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPP4 Gene

Human Gene Mutation Database (HGMD)
DPP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP4 Gene

Disorders for DPP4 Gene

MalaCards: The human disease database

(25) MalaCards diseases for DPP4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nasopharyngitis
  • chronic nasopharyngitis
mental depression
  • depression
endocrine pancreas disease
  • disorder of endocrine pancreas
pancreas disease
  • pancreatic diseases
nasopharyngeal disease
  • nasopharyngeal diseases
- elite association - COSMIC cancer census association via MalaCards
Search DPP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DPP4

Genetic Association Database (GAD)
DPP4
Human Genome Epidemiology (HuGE) Navigator
DPP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPP4
genes like me logo Genes that share disorders with DPP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPP4 Gene

Publications for DPP4 Gene

  1. Comprehensive genetic analysis of the dipeptidyl peptidase-4 gene and cardiovascular disease risk factors in obese individuals. (PMID: 18682883) Bouchard L. … Vohl M.C. (Acta Diabetol 2009) 3 22 46 64
  2. Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. (PMID: 17287217) Ohnuma K. … Morimoto C. (J. Biol. Chem. 2007) 3 4 22 64
  3. N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding. (PMID: 14691230) Aertgeerts K. … Swanson R.V. (Protein Sci. 2004) 3 4 22 64
  4. One site mutation disrupts dimer formation in human DPP-IV proteins. (PMID: 15448155) Chien C.H. … Chen X. (J. Biol. Chem. 2004) 3 4 22 64
  5. Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog. (PMID: 12483204) Rasmussen H.B. … Wagtmann N. (Nat. Struct. Biol. 2003) 3 4 22 64

Products for DPP4 Gene

Sources for DPP4 Gene

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