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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPP3 Gene

protein-coding   GIFtS: 55
GCID: GC11P066249

Dipeptidyl-Peptidase 3

(Previous names: dipeptidylpeptidase III, dipeptidylpeptidase 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dipeptidyl-Peptidase 31 2     EC 3.4.14.43 8
Dipeptidyl Aminopeptidase III2 3     Dipeptidylpeptidase 31
Dipeptidyl Arylamidase III2 3     Dipeptidylpeptidase III1
Dipeptidyl Peptidase III2 3     DPPIII2
DPP III2 3     Dipeptidyl Peptidase 32

External Ids:    HGNC: 30081   Entrez Gene: 100722   Ensembl: ENSG000002549867   OMIM: 6068185   UniProtKB: Q9NY333   

Export aliases for DPP3 gene to outside databases

Previous GC identifers: GC11P068782 GC11P067929 GC11P066497 GC11P066023 GC11P066005 GC11P066248


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPP3 Gene:
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein
binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase
activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is
associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for
this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for DPP3 Gene: 
DPP3 (dipeptidyl-peptidase 3) is a protein-coding gene. Diseases associated with DPP3 include ovarian cancer, and endometrial carcinoma. GO annotations related to this gene include dipeptidyl-peptidase activity and metallopeptidase activity.

UniProtKB/Swiss-Prot: DPP3_HUMAN, Q9NY33
Function: Cleaves Arg-Arg-beta-naphthylamide

Gene Wiki entry for DPP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPP3 gene promoter:
         Spz1   AML1a   Bach2   AP-2gamma   E47   HEN1   COMP1   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13.1   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q12-q13.1

DPP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066249:  view genomic region     (about GC identifiers)

Start:
66,247,484 bp from pter      End:
66,277,130 bp from pter
Size:
29,647 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPP3_HUMAN, Q9NY33 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 3  
Size: 737 amino acids; 82589 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Cytoplasm
Mass spectrometry: Mass=82500; Mass_error=60; Method=MALDI; Range=1-737 (Q9NY33-1); Source=PubMed:11209758;
3 PDB 3D structures from and Proteopedia for DPP3:
3FVY (3D)        3T6B (3D)        3T6J (3D)    
Secondary accessions: B2RDB5 B4DLX4 F5H8L6 O95748 Q969H2 Q9BV67 Q9HAL6
Alternative splicing: 4 isoforms:  Q9NY33-1   Q9NY33-2   Q8NFJ9-2   Q9NY33-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DPP3: NX_Q9NY33

Explore proteomics data for DPP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NY33

  • 4/11 DME Specific Peptides for DPP3 (Q9NY33) (see all 11)
     GIPAGIN  KSFGDTKF  GFKNVSLGN  LLQTSPEAP 

    DPP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPP3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243599.1  NP_005691.2  NP_569710.2  

    ENSEMBL proteins: 
     ENSP00000432782   ENSP00000435284   ENSP00000440502   ENSP00000437101   ENSP00000431606  
     ENSP00000436941   ENSP00000434518   ENSP00000436820   ENSP00000432618   ENSP00000353701  
     ENSP00000389943  

    Human Recombinant Protein Products for DPP3: 
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    OriGene MassSpec for DPP3 
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    GenScript Custom Purified and Recombinant Proteins Services for DPP3
    Novus Biologicals DPP3 Proteins
    Novus Biologicals DPP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DPP3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    DPP3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DPP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005317 Dipeptidyl-peptase3

    Graphical View of Domain Structure for InterPro Entry Q9NY33

    ProtoNet protein and cluster: Q9NY33

    1 Blocks protein domain: IPB005317 Peptidase family M49

    UniProtKB/Swiss-Prot: DPP3_HUMAN, Q9NY33
    Similarity: Belongs to the peptidase M49 family


    DPP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPP3_HUMAN, Q9NY33
    Function: Cleaves Arg-Arg-beta-naphthylamide
    Catalytic activity: Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad
    specificity. Also acts on dipeptidyl 2-naphthylamides
    Biophysicochemical properties: pH dependence: Optimum pH is 8.8;

         Enzyme Number (IUBMB): EC 3.4.14.41 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0005515protein binding IPI19615732
    GO:0008237metallopeptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity IDA10387075
    GO:0008270zinc ion binding IDA10387075
         
    DPP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DPP3:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DPP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPP3 

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate DPP3 (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-miR-3167 hsa-let-7g hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidDPP3 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of DPP3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for DPP3 (Q9NY333 ENSP000003537014) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
    ATP5C1P365423, ENSP000003491424I2D: score=4 STRING: ENSP00000349142
    HSPA8P111423, ENSP000002273784I2D: score=3 STRING: ENSP00000227378
    EFTUD1Q7Z2Z23I2D: score=1 
    OSBPL10Q9BXB53I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA10387075

    DPP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DPP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPP3

    2 Novoseek inferred chemical compound relationships for DPP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spinorphin 96.5 5 12703067 (2), 10822105 (1)
    zinc 21.6 4 11209758 (1), 17338643 (1), 9425109 (1)

    Search CenterWatch for drugs/clinical trials and news about DPP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPP3 gene (3 alternative transcripts): 
    NM_001256670.1  NM_005700.4  NM_130443.3  

    Unigene Cluster for DPP3:

    Dipeptidyl-peptidase 3
    Hs.502914  [show with all ESTs]
    Unigene Representative Sequence: NM_130443
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531863 ENST00000532677 ENST00000541961(uc001oih.1) ENST00000531272
    ENST00000532019 ENST00000526515 ENST00000530165 ENST00000533725 ENST00000544603
    ENST00000531314 ENST00000531354 ENST00000526250 ENST00000526667 ENST00000533799
    ENST00000525738 ENST00000539085 ENST00000360510(uc001oif.1) ENST00000453114(uc001oig.1 uc010rpe.1)

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate DPP3 (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-miR-3167 hsa-let-7g hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidDPP3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPP3
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP3
    Sirion Biotech Customized lentivirus for stable overexpression of DPP3 
                         Customized lentivirus expression plasmids for stable overexpression of DPP3 
    Primer
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    OriGene qPCR primer pairs and template standards for DPP3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPP3

    Additional mRNA sequence: 

    AB017970.1 AJ271216.1 AK021449.1 AK025984.1 AK222566.1 AK222847.1 AK297199.1 AK304581.1 
    AK315478.1 AL137670.1 AL833475.1 BC001446.2 BC007221.1 BC014038.2 BC024271.1 

    20 DOTS entries:

    DT.101960657  DT.100790025  DT.100695474  DT.95258042  DT.75100651  DT.100790017  DT.445088  DT.120710813 
    DT.91756464  DT.95258045  DT.102834826  DT.102834829  DT.100790023  DT.100790024  DT.100790027  DT.120710742 
    DT.95094363  DT.120710680  DT.120710778  DT.40237267 

    24/528 AceView cDNA sequences (see all 528):

    CA866961 BI752746 AA229724 CA778353 BQ060769 BQ187583 BE895930 BM149195 
    CK821160 CR625482 N71878 AI565079 BI334747 BU072804 AI282614 AI081971 
    AI078597 NM_130443 CB107365 AI672664 CO400890 BU684596 BQ066801 AI367440 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPP3 expression in normal human tissues (normalized intensities)      DPP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCGGGCCG
    DPP3 Expression
    About this image


    DPP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Oral Cavity (Gastrointestinal Tract)
             mouth   

    See DPP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPP3

    SOURCE GeneReport for Unigene cluster: Hs.502914
        SABiosciences Custom PCR Arrays for DPP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DPP3 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpp31 , 5 dipeptidylpeptidase 31, 5 87.56(n)1
    92.94(a)1
      19 (4.15 cM)5
    752211  NM_133803.21  NP_598564.21 
     49072295 
    lizard
    (Anolis carolinensis)
    Reptilia DPP36
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL344045.1(46201-60637)
    African clawed frog
    (Xenopus laevis)
    Amphibia dpp3-A-prov2 dipeptidylpeptidase 3 73.82(n)    BC043905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64b042 wufb64b04 77.97(n)   322527  CA473273.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74153
    DppIII1
    dipeptidyl-peptidase III3
    Dipeptidyl aminopeptidase III1
    48(a)3
    56.62(n)1
    49.93(a)1
      84F133
    409961  NM_169217.21  NP_731237.11 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F02E9.91 Protein F02E9.9 52.74(n)
    51.67(a)
      172631  NM_001047183.2  NP_001040648.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YOL057W)4
    YOL057W1
    Dipeptidyl-peptidase III; cleaves dipeptides from the more4
    hypothetical protein1
    45.27(n)1
    39.38(a)1
      15(220767-222902)4
    8540971, 4  NP_014584.11, 4 


    ENSEMBL Gene Tree for DPP3 (if available)
    TreeFam Gene Tree for DPP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPP3 gene
    1 SIMAP similar gene for DPP3 using alignment to 8 protein entries:     DPP3_HUMAN (see all proteins):
    DKFZp686O1117

    DPP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DPP3
    PGOHUM00000245931 PGOHUM00000236211


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/923 SNPs in DPP3 are shown (see all 923)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs788472431,2
    C,F--66165790(+) CATCCT/CGGCCA 3 -- us2k13Minor allele frequency- C:0.10WA CSA 122
    rs340843801,2
    C--66165820(+) GGTTG-/CCCCAG 3 -- us2k10--------
    rs766445301,2
    F--66165896(+) GGCTCT/GGAGTA 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1920327681,2
    --66165920(+) GGCATC/TGTCCC 3 -- us2k10--------
    rs1168803871,2
    F--66165921(+) GCATCG/ATCCCC 3 -- us2k11Minor allele frequency- A:0.02EA 120
    rs784193731,2
    C,F--66165928(+) CCCCAA/GTAGAT 3 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1445479811,2
    --66166049(+) CACCCA/GAATGT 3 -- us2k10--------
    rs1817376251,2
    --66166058(+) GTGATA/GAGAGA 3 -- us2k10--------
    rs1869416041,2
    --66166087(+) GATTCC/TTGCTT 3 -- us2k10--------
    rs1914110581,2
    --66166104(+) CATGGC/TACTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPP3 (66247484 - 66277130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DPP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744637CNV Deletion23290073
    nsv897772CNV Loss21882294
    nsv522277CNV Loss19592680
    nsv832193CNV Loss17160897
    dgv1187n71CNV Loss21882294
    nsv468601CNV Loss19166990


    Human Gene Mutation Database (HGMD): DPP3
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DPP3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606818    OMIM disorders: --

    4 diseases for DPP3:    About MalaCards
    ovarian cancer    endometrial carcinoma    cataract    glioblastoma


    DPP3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DPP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometrial carcinoma 48.8 3 14529681 (1), 9640230 (1)


    Export disorders for DPP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPP3 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with DPP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences. (PubMed id 11209758)1, 2, 9 Abramic M.... Vitale L. (2000)
    2. Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression. (PubMed id 9425109)1, 2, 9 Fukasawa K.... Harada M. (1998)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Assignment of the dipeptidyl peptidase III gene (DPP3) to human chromosome 11 band q12-->q13.1 by in situ hybridization. (PubMed id 10773679)1, 3 Fukasawa K.M....Harada M. (2000)
    7. Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue. (PubMed id 9640230)1, 9 Simaga S....Abramic M. (1998)
    8. Tumor cytosol dipeptidyl peptidase III activity is increased with histological aggressiveness of ovarian primary carcinomas. (PubMed id 14529681)1, 9 Simaga S....Abramic M. (2003)
    9. Highly reactive cysteine residues are part of the substrate binding site of mammalian dipeptidyl peptidases III. (PubMed id 14687922)1, 9 Abramic M....Dolovcak L. (2004)
    10. Ets-1/Elk-1 is a critical mediator of dipeptidyl-pept idase III transcription in human glioblastoma cells. (PubMed id 20236318)1, 9 Shukla A.A....Chauhan S.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10072 HGNC: 3008 AceView: DPP3andBBS1 Ensembl:ENSG00000254986 euGenes: HUgn10072
    ECgene: DPP3 H-InvDB: DPP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPP3 gene:
    Search GeneIP for patents involving DPP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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