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DPP3 Gene

protein-coding   GIFtS: 57
GCID: GC11P066249

Dipeptidyl-Peptidase 3

(Previous names: dipeptidylpeptidase III, dipeptidylpeptidase 3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dipeptidyl-Peptidase 31 2     EC 3.4.14.43 8
Dipeptidyl Aminopeptidase III2 3     Dipeptidylpeptidase 31
Dipeptidyl Arylamidase III2 3     Dipeptidylpeptidase III1
Dipeptidyl Peptidase III2 3     DPPIII2
Enkephalinase B2 3     Dipeptidyl Peptidase 32
DPP III2 3     

External Ids:    HGNC: 30081   Entrez Gene: 100722   Ensembl: ENSG000002549867   OMIM: 6068185   UniProtKB: Q9NY333   

Export aliases for DPP3 gene to outside databases

Previous GC identifers: GC11P068782 GC11P067929 GC11P066497 GC11P066023 GC11P066005 GC11P066248


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPP3 Gene:
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein
binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase
activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is
associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for
this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for DPP3 Gene:
DPP3 (dipeptidyl-peptidase 3) is a protein-coding gene. GO annotations related to this gene include dipeptidyl-peptidase activity and metallopeptidase activity.

UniProtKB/Swiss-Prot: DPP3_HUMAN, Q9NY33
Function: Cleaves and degrades of the opioid peptide enkephalin. Also cleaves Arg-Arg-beta-naphthylamide

Gene Wiki entry for DPP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPP3 gene promoter:
         Spz1   AML1a   Bach2   AP-2gamma   E47   HEN1   COMP1   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPP3 promoter sequence
   Search Chromatin IP Primers for DPP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13.1   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q12-q13.1

DPP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066249:  view genomic region     (about GC identifiers)

Start:
66,247,484 bp from pter      End:
66,277,130 bp from pter
Size:
29,647 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPP3_HUMAN, Q9NY33 (See protein sequence)
Recommended Name: Dipeptidyl peptidase 3  
Size: 737 amino acids; 82589 Da
Cofactor: Binds 1 zinc ion per subunit
Mass spectrometry: Mass=82500; Mass_error=60; Method=MALDI; Range=1-737 (Q9NY33-1); Source=PubMed:11209758;
3 PDB 3D structures from and Proteopedia for DPP3:
3FVY (3D)        3T6B (3D)        3T6J (3D)    
Secondary accessions: B2RDB5 B4DLX4 F5H8L6 O95748 Q969H2 Q9BV67 Q9HAL6
Alternative splicing: 4 isoforms:  Q9NY33-1   Q9NY33-2   Q8NFJ9-2   Q9NY33-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DPP3: NX_Q9NY33

Explore proteomics data for DPP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys202, Lys257, Lys629, Lys727
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DPP3 (Q9NY33) (see all 11)
     GIPAGIN  KSFGDTKF  GFKNVSLGN  LLQTSPEAP 


    See DPP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243599.1  NP_005691.2  NP_569710.2  

    ENSEMBL proteins: 
     ENSP00000432782   ENSP00000435284   ENSP00000440502   ENSP00000437101   ENSP00000431606  
     ENSP00000436941   ENSP00000434518   ENSP00000436820   ENSP00000432618   ENSP00000353701  
     ENSP00000389943  

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    Novus Biologicals DPP3 Proteins
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    Cloud-Clone Corp. Proteins for DPP3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005317 Dipeptidyl-peptase3

    Graphical View of Domain Structure for InterPro Entry Q9NY33

    ProtoNet protein and cluster: Q9NY33

    1 Blocks protein domain: IPB005317 Peptidase family M49

    UniProtKB/Swiss-Prot: DPP3_HUMAN, Q9NY33
    Similarity: Belongs to the peptidase M49 family


    Find genes that share domains with DPP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPP3_HUMAN, Q9NY33
    Function: Cleaves and degrades of the opioid peptide enkephalin. Also cleaves Arg-Arg-beta-naphthylamide
    Catalytic activity: Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad
    specificity. Also acts on dipeptidyl 2-naphthylamides
    Enzyme regulation: Inhibited by spinorphin, an opioid peptide derived from hemoglobin
    Biophysicochemical properties: pH dependence: Optimum pH is 8.8;

         Enzyme Number (IUBMB): EC 3.4.14.41 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0005515protein binding IPI19615732
    GO:0008237metallopeptidase activity IEA--
    GO:0008239dipeptidyl-peptidase activity IDA10387075
    GO:0008270zinc ion binding IDA10387075
         
    Find genes that share ontologies with DPP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DPP3:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPP3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPP3

    miRNA
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    miRTarBase miRNAs that target DPP3:
    hsa-mir-320a (MIRT044782), hsa-mir-1296-5p (MIRT036150), hsa-mir-615-3p (MIRT040357)

    Block miRNA regulation of human, mouse, rat DPP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPP3 (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-miR-3167 hsa-let-7g hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidDPP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DPP3
    Predesigned siRNA for gene silencing in human, mouse, rat DPP3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DPP3 (NM_005700)
    Sino Biological Human cDNA Clone for DPP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPP3
    Addgene plasmids for DPP3 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DPP3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPP3_HUMAN, Q9NY33: Cytoplasm

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with DPP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPP3
    Interactions:

        Search GeneGlobe Interaction Network for DPP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DPP3 (Q9NY331, 3 ENSP000003537014) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KEAP1Q141451, 3, ENSP000001711114EBI-718333,EBI-751001 I2D: score=2 STRING: ENSP00000171111
    ATP5C1P365423, ENSP000003491424I2D: score=4 STRING: ENSP00000349142
    HSPA8P111423, ENSP000002273784I2D: score=3 STRING: ENSP00000227378
    EFTUD1Q7Z2Z23I2D: score=1 
    OSBPL10Q9BXB53I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA10387075

    Find genes that share ontologies with DPP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPP3

    2 Novoseek inferred chemical compound relationships for DPP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spinorphin 96.5 5 12703067 (2), 10822105 (1)
    zinc 21.6 4 11209758 (1), 17338643 (1), 9425109 (1)



    Find genes that share compounds with DPP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPP3 gene (3 alternative transcripts): 
    NM_001256670.1  NM_005700.4  NM_130443.3  

    Unigene Cluster for DPP3:

    Dipeptidyl-peptidase 3
    Hs.502914  [show with all ESTs]
    Unigene Representative Sequence: NM_130443
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531863 ENST00000532677 ENST00000541961(uc001oih.1) ENST00000531272
    ENST00000532019 ENST00000526515 ENST00000530165 ENST00000533725 ENST00000544603
    ENST00000531314 ENST00000531354 ENST00000526250 ENST00000526667 ENST00000533799
    ENST00000525738 ENST00000539085 ENST00000360510(uc001oif.1) ENST00000453114(uc001oig.1 uc010rpe.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DPP3 (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-miR-3167 hsa-let-7g hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidDPP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPP3
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    Addgene plasmids for DPP3 
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    OriGene qPCR primer pairs and template standards for DPP3
    OriGene qSTAR qPCR primer pairs in human, mouse for DPP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPP3
      QuantiTect SYBR Green Assays in human, mouse, rat DPP3
      QuantiFast Probe-based Assays in human, mouse, rat DPP3

    Additional mRNA sequence: 

    AB017970.1 AJ271216.1 AK021449.1 AK025984.1 AK222566.1 AK222847.1 AK297199.1 AK304581.1 
    AK315478.1 AL137670.1 AL833475.1 BC001446.2 BC007221.1 BC014038.2 BC024271.1 

    20 DOTS entries:

    DT.101960657  DT.100790025  DT.100695474  DT.95258042  DT.75100651  DT.100790017  DT.445088  DT.120710813 
    DT.91756464  DT.95258045  DT.102834826  DT.102834829  DT.100790023  DT.100790024  DT.100790027  DT.120710742 
    DT.95094363  DT.120710680  DT.120710778  DT.40237267 

    Selected AceView cDNA sequences (see all 528):

    BI334747 AA496618 Z39189 AI309772 BX282098 CR625482 AF503941 Z43096 
    BG576251 AI367440 BI752746 BQ686543 AW002200 AI313232 BC007221 AK021449 
    BI759657 BQ187583 AA186601 AA053825 AA227550 AI524111 BM927031 CD367736 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCGGGCCG
    DPP3 Expression
    About this image


    DPP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    DPP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502914
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DPP3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpp31 , 5 dipeptidylpeptidase 31, 5 87.56(n)1
    92.94(a)1
      19 (4.15 cM)5
    752211  NM_133803.21  NP_598564.21 
     49072295 
    lizard
    (Anolis carolinensis)
    Reptilia DPP36
    dipeptidyl-peptidase 3
    69(a)
    1 ↔ 1
    GL344045.1(46201-60637)
    African clawed frog
    (Xenopus laevis)
    Amphibia dpp3-A-prov2 dipeptidylpeptidase 3 73.82(n)    BC043905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64b042 wufb64b04 77.97(n)   322527  CA473273.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74153
    DppIII1
    dipeptidyl-peptidase III3
    Dipeptidyl aminopeptidase III1
    48(a)3
    56.87(n)1
    50(a)1
      84F133
    409961  NM_169217.21  NP_731237.11 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F02E9.91 CELE_F02E9.9 52.89(n)
    51.97(a)
      172631  NM_001047183.3  NP_001040648.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YOL057W)4
    YOL057W1
    Dipeptidyl-peptidase III; cleaves dipeptides from the more4
    YOL057W1
    45.17(n)1
    39.23(a)1
      15(220767-222902)4
    8540971, 4  NP_014584.11, 4 


    ENSEMBL Gene Tree for DPP3 (if available)
    TreeFam Gene Tree for DPP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPP3 gene
    1 SIMAP similar gene for DPP3 using alignment to 8 protein entries:     DPP3_HUMAN (see all proteins):
    DKFZp686O1117

    Find genes that share paralogs with DPP3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DPP3
    PGOHUM00000245931 PGOHUM00000236211


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPP3 (see all 923)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs788472431,2
    C,F--66165790(+) CATCCT/CGGCCA 3 -- us2k13Minor allele frequency- C:0.10WA CSA 122
    rs340843801,2
    C--66165820(+) GGTTG-/CCCCAG 3 -- us2k10--------
    rs766445301,2
    F--66165896(+) GGCTCT/GGAGTA 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1920327681,2
    --66165920(+) GGCATC/TGTCCC 3 -- us2k10--------
    rs1168803871,2
    F--66165921(+) GCATCG/ATCCCC 3 -- us2k11Minor allele frequency- A:0.02EA 120
    rs784193731,2
    C,F--66165928(+) CCCCAA/GTAGAT 3 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1445479811,2
    --66166049(+) CACCCA/GAATGT 3 -- us2k10--------
    rs1817376251,2
    --66166058(+) GTGATA/GAGAGA 3 -- us2k10--------
    rs1869416041,2
    --66166087(+) GATTCC/TTGCTT 3 -- us2k10--------
    rs1914110581,2
    --66166104(+) CATGGC/TACTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPP3 (66247484 - 66277130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DPP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744637CNV Deletion23290073
    nsv897772CNV Loss21882294
    nsv522277CNV Loss19592680
    nsv832193CNV Loss17160897
    dgv1187n71CNV Loss21882294
    nsv468601CNV Loss19166990

    Human Gene Mutation Database (HGMD): DPP3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DPP3
    DNA2.0 Custom Variant and Variant Library Synthesis for DPP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606818    OMIM disorders: --


    Find genes that share disorders with DPP3           About GenesLikeMe

    1 Novoseek inferred disease relationship for DPP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometrial carcinoma 48.8 3 14529681 (1), 9640230 (1)


    Export disorders for DPP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPP3 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with DPP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences. (PubMed id 11209758)1, 2, 9 Abramic M.... Vitale L. (Biol. Chem. 2000)
    2. Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression. (PubMed id 9425109)1, 2, 9 Fukasawa K.... Harada M. (Biochem. J. 1998)
    3. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. (PubMed id 22493238)1, 2 Bezerra G.A....Gruber K. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Assignment of the dipeptidyl peptidase III gene (DPP3) to human chromosome 11 band q12--&gt;q13.1 by in situ hybridization. (PubMed id 10773679)1, 3 Fukasawa K.M....Harada M. (Cytogenet. Cell Genet. 2000)
    8. Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue. (PubMed id 9640230)1, 9 Simaga S....AbramiA8 M. (Eur. J. Cancer 1998)
    9. Tumor cytosol dipeptidyl peptidase III activity is increased with histological aggressiveness of ovarian primary carcinomas. (PubMed id 14529681)1, 9 Simaga S....AbramiA8 M. (Gynecol. Oncol. 2003)
    10. Highly reactive cysteine residues are part of the substrate binding site of mammalian dipeptidyl peptidases III. (PubMed id 14687922)1, 9 AbramiA8 M....Dolovcak L. (amp 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10072 HGNC: 3008 AceView: DPP3andBBS1 Ensembl:ENSG00000254986 euGenes: HUgn10072
    ECgene: DPP3 H-InvDB: DPP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPP3 gene:
    Search GeneIP for patents involving DPP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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