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Aliases for DPP3 Gene

Aliases for DPP3 Gene

  • Dipeptidyl Peptidase 3 2 3 5
  • Dipeptidyl Aminopeptidase III 3 4
  • Dipeptidyl Arylamidase III 3 4
  • Dipeptidyl Peptidase III 3 4
  • Enkephalinase B 3 4
  • EC 3.4.14.4 4 61
  • DPP III 3 4
  • Dipeptidylpeptidase III 2
  • Dipeptidyl-Peptidase 3 2
  • Dipeptidylpeptidase 3 2
  • DPPIII 3

External Ids for DPP3 Gene

Previous GeneCards Identifiers for DPP3 Gene

  • GC11P068782
  • GC11P067929
  • GC11P066023
  • GC11P066005
  • GC11P066248
  • GC11P066249

Summaries for DPP3 Gene

Entrez Gene Summary for DPP3 Gene

  • This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for DPP3 Gene

DPP3 (Dipeptidyl Peptidase 3) is a Protein Coding gene. GO annotations related to this gene include metallopeptidase activity and dipeptidyl-peptidase activity.

UniProtKB/Swiss-Prot for DPP3 Gene

  • Cleaves and degrades of the opioid peptide enkephalin. Also cleaves Arg-Arg-beta-naphthylamide.

Gene Wiki entry for DPP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP3 Gene

Genomics for DPP3 Gene

Regulatory Elements for DPP3 Gene

Enhancers for DPP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F066508 1.1 ENCODE 26.1 +30.1 30116 2.9 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KLF13 MRPL11 DPP3 LOC101928069 CTSF CD248 CLCF1 PELI3 SSSCA1 EHBP1L1 LOC105369353
GH11F066342 1.8 FANTOM5 Ensembl ENCODE 11.2 -131.5 -131469 11.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ENSG00000258297 RBM14 RIN1 MRPL11 SSSCA1-AS1 EIF1AD RCE1 LOC105369352 CD248 ACTN3
GH11F066542 1.4 Ensembl ENCODE 14.3 +66.0 65980 6.2 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ACTN3 CTSF DPP3 CTSW TBC1D10C RIN1 ZDHHC24 GC11M066536
GH11F066965 1.7 FANTOM5 Ensembl ENCODE 11.1 +489.0 489040 6.8 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 BRCA1 YY1 GTF3C2 SLC30A9 RAD9A EIF1AD CLCF1 ENSG00000258297 PC RBM14 RCE1 BRMS1 DPP3 ENSG00000245156
GH11F066478 1.1 ENCODE 17 +0.3 331 3.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ACTN3 DPP3 CTSF C11orf80 MRPL11 LOC105369352 EIF1AD LOC101928069 RHOD ENSG00000256349
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPP3 on UCSC Golden Path with GeneCards custom track

Promoters for DPP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000564027 87 2201 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF143

Genomic Location for DPP3 Gene

Chromosome:
11
Start:
66,480,013 bp from pter
End:
66,509,659 bp from pter
Size:
29,647 bases
Orientation:
Plus strand

Genomic View for DPP3 Gene

Genes around DPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP3 Gene

Proteins for DPP3 Gene

  • Protein details for DPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY33-DPP3_HUMAN
    Recommended name:
    Dipeptidyl peptidase 3
    Protein Accession:
    Q9NY33
    Secondary Accessions:
    • B2RDB5
    • B4DLX4
    • F5H8L6
    • O95748
    • Q969H2
    • Q9BV67
    • Q9HAL6

    Protein attributes for DPP3 Gene

    Size:
    737 amino acids
    Molecular mass:
    82589 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DPP3 Gene

    Alternative splice isoforms for DPP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPP3 Gene

Selected DME Specific Peptides for DPP3 Gene

Q9NY33:
  • PDFTSLDVLTFAGSG
  • VILRVLLEAGE
  • GIPAGIN
  • LLQTSPEAP
  • YIGFIESYRDPFG
  • VQVGLHELLGHGSGKLF
  • GFKNVSLGN
  • YVNWLNMVRAGLL
  • PAGINIPNYD
  • KSFGDTKF
  • WRQAHMQAR

Post-translational modifications for DPP3 Gene

  • Ubiquitination at Lys 202, Lys 257, Lys 629, and Lys 727
  • Modification sites at PhosphoSitePlus

Domains & Families for DPP3 Gene

Protein Domains for DPP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DPP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY33

UniProtKB/Swiss-Prot:

DPP3_HUMAN :
  • Belongs to the peptidase M49 family.
Family:
  • Belongs to the peptidase M49 family.
genes like me logo Genes that share domains with DPP3: view

No data available for Gene Families for DPP3 Gene

Function for DPP3 Gene

Molecular function for DPP3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.8.;
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by spinorphin, an opioid peptide derived from hemoglobin.
UniProtKB/Swiss-Prot Function:
Cleaves and degrades of the opioid peptide enkephalin. Also cleaves Arg-Arg-beta-naphthylamide.

Enzyme Numbers (IUBMB) for DPP3 Gene

Gene Ontology (GO) - Molecular Function for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19615732
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IDA 9425109
GO:0008270 zinc ion binding IDA 9425109
genes like me logo Genes that share ontologies with DPP3: view
genes like me logo Genes that share phenotypes with DPP3: view

Animal Model Products

miRNA for DPP3 Gene

miRTarBase miRNAs that target DPP3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DPP3

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPP3 Gene

Localization for DPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP3 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 4
lysosome 1

Gene Ontology (GO) - Cellular Components for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DPP3: view

Pathways & Interactions for DPP3 Gene

No Data Available

Interacting Proteins for DPP3 Gene

Gene Ontology (GO) - Biological Process for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 9425109
genes like me logo Genes that share ontologies with DPP3: view

No data available for Pathways by source and SIGNOR curated interactions for DPP3 Gene

Drugs & Compounds for DPP3 Gene

(2) Drugs for DPP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DPP3: view

Transcripts for DPP3 Gene

Unigene Clusters for DPP3 Gene

Dipeptidyl-peptidase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DPP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPP3 Gene

No ASD Table

Relevant External Links for DPP3 Gene

GeneLoc Exon Structure for
DPP3
ECgene alternative splicing isoforms for
DPP3

Expression for DPP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPP3 Gene

This gene is overexpressed in Lymph node (9.6) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPP3 Gene



Protein tissue co-expression partners for DPP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPP3 Gene:

DPP3

SOURCE GeneReport for Unigene cluster for DPP3 Gene:

Hs.502914
genes like me logo Genes that share expression patterns with DPP3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPP3 Gene

Orthologs for DPP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP3 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia DPP3 34 35
  • 90.99 (n)
dog
(Canis familiaris)
Mammalia DPP3 34 35
  • 90.45 (n)
mouse
(Mus musculus)
Mammalia Dpp3 34 16 35
  • 87.56 (n)
rat
(Rattus norvegicus)
Mammalia Dpp3 34
  • 87.43 (n)
oppossum
(Monodelphis domestica)
Mammalia DPP3 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPP3 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP3 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp3 34
  • 63.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia dpp3-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii dpp3 34 35
  • 68.37 (n)
wufb64b04 34
fruit fly
(Drosophila melanogaster)
Insecta DppIII 34 35
  • 56.87 (n)
CG7415 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004394 34
  • 54.59 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F02E9.9 34
  • 52.89 (n)
dpt-1 35
  • 48 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER229C 34
  • 48.16 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04059g 34
  • 46.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOL057W 34
  • 45.17 (n)
-- 35
  • 36 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02701 34
  • 52.11 (n)
Species where no ortholog for DPP3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP3 Gene

ENSEMBL:
Gene Tree for DPP3 (if available)
TreeFam:
Gene Tree for DPP3 (if available)

Paralogs for DPP3 Gene

(1) SIMAP similar genes for DPP3 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for DPP3 Gene

genes like me logo Genes that share paralogs with DPP3: view

No data available for Paralogs for DPP3 Gene

Variants for DPP3 Gene

Sequence variations from dbSNP and Humsavar for DPP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10501397 -- 66,505,505(-) TTCAC(G/T)ATAAC intron-variant
rs10791878 -- 66,495,335(+) CCACC(C/T)TAAGC intron-variant
rs111339967 -- 66,486,274(+) GGGGT(C/T)TCTCT intron-variant
rs111424029 -- 66,479,620(+) AGGCC(C/T)TTCCG intron-variant, upstream-variant-2KB
rs111462457 -- 66,494,630(+) AGAGA(C/G)AGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP3 Gene

Variant ID Type Subtype PubMed ID
nsv832193 CNV loss 17160897
nsv555224 CNV loss 21841781
nsv522277 CNV loss 19592680
nsv476256 CNV novel sequence insertion 20440878
nsv468601 CNV loss 19166990
esv2744637 CNV deletion 23290073

Variation tolerance for DPP3 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.35; 95.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPP3 Gene

Human Gene Mutation Database (HGMD)
DPP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP3 Gene

Disorders for DPP3 Gene

Relevant External Links for DPP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPP3

No disorders were found for DPP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPP3 Gene

Publications for DPP3 Gene

  1. Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences. (PMID: 11209758) Abramic M. … Vitale L. (Biol. Chem. 2000) 3 4 22 64
  2. Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression. (PMID: 9425109) Fukasawa K. … Harada M. (Biochem. J. 1998) 3 4 22 64
  3. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. (PMID: 22493238) Bezerra G.A. … Gruber K. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
  4. Ets-1/Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells. (PMID: 20236318) Shukla A.A. … Chauhan S.S. (FEBS J. 2010) 3 22 64
  5. Functional tyrosine residue in the active center of human dipeptidyl peptidase III. (PMID: 18163885) Salopek-Sondi B. … AbramiA8 M. (Biol. Chem. 2008) 3 22 64

Products for DPP3 Gene

Sources for DPP3 Gene

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