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Aliases for DPP10 Gene

Aliases for DPP10 Gene

  • Dipeptidyl-Peptidase 10 (Non-Functional) 2 3
  • DPRP3 3 4 6
  • Dipeptidyl Peptidase IV-Related Protein 3 3 4
  • Dipeptidyl Peptidase-Like Protein 2 3 4
  • Dipeptidyl Peptidase X 3 4
  • KIAA1492 4 6
  • DPRP-3 3 4
  • DPP X 3 4
  • DPL2 3 4
  • Inactive Dipeptidyl Peptidase 10 3
  • Dipeptidyl-Peptidase 10 2
  • Dipeptidyl Peptidase 10 3
  • Dipeptidylpeptidase 10 2
  • DPPY 3

External Ids for DPP10 Gene

Summaries for DPP10 Gene

Entrez Gene Summary for DPP10 Gene

  • This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP10 Gene

DPP10 (Dipeptidyl-Peptidase 10 (Non-Functional)) is a Protein Coding gene. Diseases associated with DPP10 include asthma. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot for DPP10 Gene

  • Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).

Gene Wiki entry for DPP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP10 Gene

Genomics for DPP10 Gene

Genomic Location for DPP10 Gene

Start:
114,442,299 bp from pter
End:
115,845,752 bp from pter
Size:
1,403,454 bases
Orientation:
Plus strand

Genomic View for DPP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP10 Gene

Regulatory Elements for DPP10 Gene

Proteins for DPP10 Gene

  • Protein details for DPP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N608-DPP10_HUMAN
    Recommended name:
    Inactive dipeptidyl peptidase 10
    Protein Accession:
    Q8N608
    Secondary Accessions:
    • A8K1Q2
    • J3KPP2
    • J3KQ46
    • Q0GLB8
    • Q53QT3
    • Q53S86
    • Q53SL8
    • Q53SS4
    • Q6TTV4
    • Q86YR9
    • Q9P236

    Protein attributes for DPP10 Gene

    Size:
    796 amino acids
    Molecular mass:
    90888 Da
    Quaternary structure:
    • May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.
    SequenceCaution:
    • Sequence=BAA96016.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DPP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPP10 Gene

Proteomics data for DPP10 Gene at MOPED

Post-translational modifications for DPP10 Gene

  • N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn90, Asn111, Asn119, Asn257, Asn342, Asn748, and Asn760

No data available for DME Specific Peptides for DPP10 Gene

Domains for DPP10 Gene

Protein Domains for DPP10 Gene

UniProtKB/Swiss-Prot:

DPP10_HUMAN
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.:
    • Q8N608
genes like me logo Genes that share domains with DPP10: view

No data available for Gene Families for DPP10 Gene

Function for DPP10 Gene

Molecular function for DPP10 Gene

UniProtKB/Swiss-Prot Function: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).

Gene Ontology (GO) - Molecular Function for DPP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008236 serine-type peptidase activity IEA --
GO:0008239 NOT dipeptidyl-peptidase activity IDA 12662155
GO:0015459 potassium channel regulator activity ISS --
genes like me logo Genes that share ontologies with DPP10: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DPP10 Gene

Localization for DPP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP10 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPP10 Gene COMPARTMENTS Subcellular localization image for DPP10 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DPP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IDA 12662155
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPP10: view

Pathways for DPP10 Gene

SuperPathways for DPP10 Gene

No Data Available

Interacting Proteins for DPP10 Gene

Gene Ontology (GO) - Biological Process for DPP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0072659 protein localization to plasma membrane ISS --
GO:0090004 positive regulation of establishment of protein localization to plasma membrane IDA 15671030
GO:1901379 regulation of potassium ion transmembrane transport ISS --
genes like me logo Genes that share ontologies with DPP10: view

No data available for Pathways by source for DPP10 Gene

Compounds for DPP10 Gene

(2) Novoseek inferred chemical compound relationships for DPP10 Gene

Compound -log(P) Hits PubMed IDs
serine 28.6 4
potassium 17.4 1
genes like me logo Genes that share compounds with DPP10: view

Transcripts for DPP10 Gene

Unigene Clusters for DPP10 Gene

Dipeptidyl-peptidase 10 (non-functional):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - - - - - - -
SP2: - -
SP3: - - - -
SP4:
SP5: - -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for DPP10 Gene

GeneLoc Exon Structure for
DPP10
ECgene alternative splicing isoforms for
DPP10

Expression for DPP10 Gene

mRNA expression in normal human tissues for DPP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPP10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.1), Brain - Anterior cingulate cortex (BA24) (7.2), Brain - Cortex (6.1), and Brain - Amygdala (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DPP10 Gene

SOURCE GeneReport for Unigene cluster for DPP10 Gene Hs.580539

mRNA Expression by UniProt/SwissProt for DPP10 Gene

Q8N608-DPP10_HUMAN
Tissue specificity: Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
genes like me logo Genes that share expressions with DPP10: view

Orthologs for DPP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP10 36
  • 99.33 (n)
  • 99.37 (a)
DPP10 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPP10 36
  • 92.88 (n)
  • 95.25 (a)
DPP10 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPP10 36
  • 93.19 (n)
  • 95.02 (a)
DPP10 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp10 36
  • 86.79 (n)
  • 89.12 (a)
Dpp10 16
Dpp10 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPP10 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPP10 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpp10 36
  • 86.12 (n)
  • 88.89 (a)
chicken
(Gallus gallus)
Aves DPP10 36
  • 80.31 (n)
  • 85.11 (a)
DPP10 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP10 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp10 36
  • 69.27 (n)
  • 74.84 (a)
zebrafish
(Danio rerio)
Actinopterygii DPP10 37
  • 41 (a)
OneToOne
LOC101886435 36
  • 54.25 (n)
  • 48.47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008764 36
  • 46.47 (n)
  • 37.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11319 36
  • 46.54 (n)
  • 38.32 (a)
worm
(Caenorhabditis elegans)
Secernentea dpf-1 36
  • 45.16 (n)
  • 31.58 (a)
dpf-3 37
  • 15 (a)
OneToMany
Species with no ortholog for DPP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP10 Gene

ENSEMBL:
Gene Tree for DPP10 (if available)
TreeFam:
Gene Tree for DPP10 (if available)

Paralogs for DPP10 Gene

Paralogs for DPP10 Gene

Selected SIMAP similar genes for DPP10 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for DPP10 Gene

genes like me logo Genes that share paralogs with DPP10: view

Variants for DPP10 Gene

Sequence variations from dbSNP and Humsavar for DPP10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs175354 -- 115,840,485(-) TTAGC(C/T)GGTGT intron-variant
rs272007 -- 115,844,777(-) AATTA(A/C/T)AGAAT downstream-variant-500B, utr-variant-3-prime, nc-transcript-variant
rs272008 -- 115,844,055(-) ACCCA(A/G)TGGAG utr-variant-3-prime, nc-transcript-variant
rs272009 -- 115,842,351(-) AATAC(A/G)GTCCA utr-variant-3-prime, nc-transcript-variant
rs272010 -- 115,842,083(-) AATTC(A/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP10 Gene

Variant ID Type Subtype PubMed ID
nsv874904 CNV Loss 21882294
nsv874906 CNV Gain 21882294
nsv834337 CNV Gain 17160897
esv1920692 CNV Deletion 18987734
esv2720560 CNV Deletion 23290073
esv1621943 CNV Deletion 17803354
esv2259036 CNV Deletion 18987734
esv2720562 CNV Deletion 23290073
esv2720563 CNV Deletion 23290073
esv1031832 CNV Deletion 17803354
esv2720564 CNV Deletion 23290073
nsv834338 CNV Loss 17160897
nsv437290 CNV Loss 16327808
esv26077 CNV Loss 19812545
esv2657725 CNV Deletion 23128226
nsv10134 CNV Loss 18304495
nsv516975 CNV Loss 19592680
esv2421461 CNV Deletion 20811451
nsv442828 CNV CNV 18776908
nsv514085 CNV Loss 21397061
esv2720565 CNV Deletion 23290073
esv23278 CNV Gain 19812545
nsv459019 CNV Loss 19166990
dgv4284n71 CNV Loss 21882294
dgv4285n71 CNV Loss 21882294
dgv4286n71 CNV Loss 21882294
esv2720566 CNV Deletion 23290073
nsv470481 CNV Loss 18288195
nsv437513 CNV Loss 16327808
esv2720567 CNV Deletion 23290073
esv2720568 CNV Deletion 23290073
nsv523446 CNV Loss 19592680
esv2659076 CNV Deletion 23128226
nsv515750 CNV Loss 19592680
nsv526597 CNV Loss 19592680
nsv441776 CNV CNV 18776908
nsv514086 CNV Loss 21397061
esv273231 CNV Insertion 20981092
nsv522770 CNV Loss 19592680
nsv874916 CNV Loss 21882294
esv2720569 CNV Deletion 23290073
esv2601468 CNV Deletion 19546169
nsv511185 CNV Loss 21212237
nsv821025 CNV Deletion 20802225
nsv829626 CNV Loss 20364138
nsv511807 CNV Loss 21212237
esv2127128 CNV Deletion 18987734
esv29876 CNV Gain+Loss 19812545
nsv829627 CNV Loss 20364138
esv3967 CNV Deletion 18987735
esv2720570 CNV Deletion 23290073
esv1005195 CNV Deletion 20482838
esv5817 CNV Loss 19470904
nsv829628 CNV Loss 20364138
nsv2885 CNV Loss 18451855
nsv874917 CNV Loss 21882294
esv2668921 CNV Deletion 23128226
esv1001957 CNV Deletion 20482838
dgv474n27 CNV Loss 19166990
esv273926 CNV Insertion 20981092
esv269203 CNV Insertion 20981092
nsv520403 CNV Loss 19592680
esv2554100 CNV Deletion 19546169
nsv834339 CNV Gain 17160897
nsv526317 CNV Gain 19592680
nsv522754 CNV Gain 19592680
nsv874918 CNV Loss 21882294
esv2720571 CNV Deletion 23290073
esv2720573 CNV Deletion 23290073
esv2720574 CNV Deletion 23290073
esv2720575 CNV Deletion 23290073
nsv874919 CNV Gain 21882294
esv2720576 CNV Deletion 23290073
esv2720577 CNV Deletion 23290073
esv2720578 CNV Deletion 23290073
esv2720579 CNV Deletion 23290073
esv1285088 CNV Deletion 17803354
esv2494215 CNV Deletion 19546169
esv21902 CNV Loss 19812545
esv5605 CNV Gain 19470904
esv269844 CNV Insertion 20981092
esv274371 CNV Insertion 20981092
esv2660787 CNV Deletion 23128226
nsv874920 CNV Loss 21882294
esv268410 CNV Insertion 20981092
nsv520606 CNV Gain 19592680
essv5982 CNV CNV 17122850
esv35070 CNV Gain 17911159
dgv1241e1 CNV Complex 17122850
esv2664172 CNV Deletion 23128226
esv28528 CNV Loss 19812545
nsv10135 CNV Gain+Loss 18304495
nsv829629 CNV Gain 20364138
dgv4287n71 CNV Gain 21882294
dgv4288n71 CNV Gain 21882294
nsv459052 CNV Gain 19166990

Relevant External Links for DPP10 Gene

HapMap Linkage Disequilibrium report
DPP10
Human Gene Mutation Database (HGMD)
DPP10

Disorders for DPP10 Gene

UniProtKB/Swiss-Prot

DPP10_HUMAN
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:14566338, ECO:0000269 PubMed:19237393}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) MalaCards Diseases for DPP10 Gene

Search for DPP10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DPP10 Gene

(1) Novoseek inferred disease relationships for DPP10 Gene

Disease -log(P) Hits PubMed IDs
asthma 43 9

Relevant External Links for DPP10

Genetic Association Database (GAD)
DPP10
Human Genome Epidemiology (HuGE) Navigator
DPP10
genes like me logo Genes that share disorders with DPP10: view

Publications for DPP10 Gene

  1. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PMID: 12662155) Qi S.Y. … Akinsanya K.O. (Biochem. J. 2003) 2 3 4 23
  2. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). (PMID: 15454437) Jerng H.H. … Pfaffinger P.J. (Biophys. J. 2004) 3 4 23
  3. Species and tissue differences in the expression of DPPY splicing variants. (PMID: 16899223) Takimoto K. … Yoshimura N. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  4. Polymorphisms of PHF11 and DPP10 are associated with asthma and related traits in a Chinese population. (PMID: 19672052) Gao J. … Zhang Y. (Respiration 2010) 3 23 49
  5. A genome-wide association study on African-ancestry populations for asthma. (PMID: 19910028) Mathias R.A. … Barnes K.C. (J. Allergy Clin. Immunol. 2010) 3 23 49

Products for DPP10 Gene

Sources for DPP10 Gene

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