Aliases for DPP10 Gene
External Ids for DPP10 Gene
Previous GeneCards Identifiers for DPP10 Gene
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for DPP10 Gene
DPP10 (Dipeptidyl-Peptidase 10 (Non-Functional)) is a Protein Coding gene. Diseases associated with DPP10 include bronchial disease and respiratory system disease. GO annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is FAP.
UniProtKB/Swiss-Prot for DPP10 Gene
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).