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DPM3 Gene

protein-coding   GIFtS: 57
GCID: GC01M155112

Dolichyl-Phosphate Mannosyltransferase Polypeptide 3

  See DPM3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dolichyl-Phosphate Mannosyltransferase Polypeptide 31 2     DPM Synthase Complex Subunit1
Dolichol-Phosphate Mannose Synthase Subunit 32 3     Dolichol-Phosphate Mannosyltransferase Subunit 32
Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 32 3     DPM Synthase Complex Subunit 32
Mannose-P-Dolichol Synthase Subunit 32 3     Prostin 12
DPM Synthase Subunit 32 3     prostin-12
MPD Synthase Subunit 32 3     Prostin-13
CDG1O2 5     

External Ids:    HGNC: 30071   Entrez Gene: 543442   Ensembl: ENSG000001790857   OMIM: 6059515   UniProtKB: Q9P2X03   

Export aliases for DPM3 gene to outside databases

Previous GC identifers: GC01M152991 GC01M150852 GC01M151887 GC01M152329 GC01M151925 GC01M153379 GC01M126474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPM3 Gene:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the
endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins.
Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme
dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate
mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DPM3 Gene:
DPM3 (dolichyl-phosphate mannosyltransferase polypeptide 3) is a protein-coding gene. Diseases associated with DPM3 include congenital disorder of glycosylation, type io. GO annotations related to this gene include dolichyl-phosphate beta-D-mannosyltransferase activity.

UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0
Function: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit
DPM1 to the ER

Gene Wiki entry for DPM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPM3 gene promoter:
         Pax-5   Lmo2   STAT3   HNF-4alpha2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPM3 promoter sequence
   Search Chromatin IP Primers for DPM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

DPM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155112:  view genomic region     (about GC identifiers)

Start:
155,112,367 bp from pter      End:
155,113,071 bp from pter
Size:
705 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0 (See protein sequence)
Recommended Name: Dolichol-phosphate mannosyltransferase subunit 3  
Size: 92 amino acids; 10094 Da
Subunit: Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in
the complex associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion
Secondary accessions: Q5SR62 Q5SR63 Q9BXN4 Q9BXN5
Alternative splicing: 2 isoforms:  Q9P2X0-1   Q9P2X0-2   

Explore the universe of human proteins at neXtProt for DPM3: NX_Q9P2X0

Explore proteomics data for DPM3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr63
  • Modification sites at PhosphoSitePlus

  • See DPM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061846.2  NP_714963.1  

    ENSEMBL proteins: 
     ENSP00000357384   ENSP00000357385   ENSP00000344338  
    Reactome Protein details: Q9P2X0

    DPM3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DPM3

     
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    Search eBioscience for ELISAs for DPM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013174 DPM3

    Graphical View of Domain Structure for InterPro Entry Q9P2X0

    ProtoNet protein and cluster: Q9P2X0

    UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0
    Similarity: Belongs to the DPM3 family


    Find genes that share domains with DPM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPM3_HUMAN, Q9P2X0
    Function: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit
    DPM1 to the ER

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004582contributes to dolichyl-phosphate beta-D-mannosyltransferase activity IDA10835346
    GO:0005515protein binding IPI10835346
         
    Find genes that share ontologies with DPM3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DPM3:
     Increased G1 DNA content 

         1 MGI phenotypic allele for Dpm3 (no phenotypes)

    Find genes that share phenotypes with DPM3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DPM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPM3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DPM3:
    hsa-mir-615-3p (MIRT040333)

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    Search for qRT-PCR Assays for microRNAs that regulate DPM3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPM3_HUMAN, Q9P2X0: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    plasma membrane2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA10835346
    GO:0005789endoplasmic reticulum membrane TAS16280320
    GO:0030176integral component of endoplasmic reticulum membrane IDA10835346
    GO:0031501mannosyltransferase complex TAS16280320
    GO:0033185dolichol-phosphate-mannose synthase complex IDA10835346

    Find genes that share ontologies with DPM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DPM3 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    N-Glycan biosynthesis0.49
    dolichyl-diphosphooligosaccharide biosynthesis0.00
    Post-translational protein modification0.43
    Synthesis of substrates in N-glycan biosythesis0.00
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.38
    Synthesis of dolichyl-phosphate mannose0.00
    2Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with DPM3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DPM3
        dolichyl-diphosphooligosaccharide biosynthesis

    1 Reactome Pathway for DPM3
        Synthesis of dolichyl-phosphate mannose


    2 Kegg Pathways  (Kegg details for DPM3):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0
    Pathway: Protein modification; protein glycosylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPM3
    Interactions:

        GeneGlobe Interaction Network for DPM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for DPM3 (Q9P2X03 ENSP000003573844) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPM1O607623, ENSP000003606444I2D: score=2 STRING: ENSP00000360644
    DPM2O947773, ENSP000003221814I2D: score=1 STRING: ENSP00000322181
    ALG1ENSP000002623744STRING: ENSP00000262374
    ALG3ENSP000003807934STRING: ENSP00000380793
    ALG5ENSP000002398914STRING: ENSP00000239891
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS10835346
    GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process TAS16280320
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    Find genes that share ontologies with DPM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPM3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPM3 gene (2 alternative transcripts): 
    NM_018973.3  NM_153741.1  

    Unigene Cluster for DPM3:

    Dolichyl-phosphate mannosyltransferase polypeptide 3
    Hs.110477  [show with all ESTs]
    Unigene Representative Sequence: AI557533
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368399(uc001fhm.3) ENST00000368400(uc001fhn.3) ENST00000341298

    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DPM3 (NM_153741)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPM3
      QuantiTect SYBR Green Assays in human, mouse, rat DPM3
      QuantiFast Probe-based Assays in human, mouse, rat DPM3

    Additional mRNA sequence: 

    AB028128.1 AF312922.1 AF312923.1 AK293625.1 BC032223.2 BC065233.1 BC104202.1 BC104203.2 
    BC104481.1 BC131546.1 

    4 DOTS entries:

    DT.100021589  DT.92416857  DT.92416859  DT.95103854 

    Selected AceView cDNA sequences (see all 74):

    BC065233 AI494511 AA335870 BM665721 NM_153741 AI360027 AF312923 F28287 
    NM_018973 BC032223 CK904114 BE222369 AI494306 AA372036 BU191858 T80897 
    AB028128 AI308812 AW005317 AI339952 F37100 AI870667 AI832631 BE670311 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCGAGGA
    DPM3 Expression
    About this image

    DPM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.110477
        Custom PCR Arrays for DPM3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPM3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpm31 , 5 dolichyl-phosphate mannosyltransferase polypeptide more1, 5 85.14(n)1
    90.22(a)1
      3 (39.03 cM)5
    685631  NM_026767.41  NP_081043.11 
     892593585 
    lizard
    (Anolis carolinensis)
    Reptilia DPM36
    dolichyl-phosphate mannosyltransferase polypeptide...
    57(a)
    1 ↔ 1
    AAWZ02039190(6779-7060)
    zebrafish
    (Danio rerio)
    Actinopterygii dpm31 dolichyl-phosphate mannosyltransferase polypeptide more 57.88(n)
    56.04(a)
      393782  NM_200809.2  NP_957103.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG339776
    --
    39(a)
    1 ↔ 1
    3R(9228281-9228771)


    ENSEMBL Gene Tree for DPM3 (if available)
    TreeFam Gene Tree for DPM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPM3 gene

    Find genes that share paralogs with DPM3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DPM3
    PGOHUM00000247259 PGOHUM00000249666


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPM3 (see all 58)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0625184
    Congenital disorder of glycosylation 1O (CDG1O)4--see VAR_0625182 L S mis40--------
    rs1219081551,2
    Cpathogenic1161614552(-) CGACTC/TAGCCC 4 S L mis10--------
    rs127455761,2
    C,F,A,Huntested1161615163(+) TTCACA/CTGGCG 2 -- us2k17Minor allele frequency- C:0.01NS EA NA 422
    rs49710731,2
    C,F,A,Huntested1161615193(+) CCAGCG/TCCTCA 2 -- us2k125Minor allele frequency- T:0.46EA NA NS WA 2610
    rs1879160631,2
    C--161614182(+) ACTCCA/GGCCTG 2 -- ds50010--------
    rs2016471211,2
    C--161614227(-) TACTTC/TTNNNN 2 -- ds50010--------
    rs1142655041,2
    F--161614427(+) CAATAC/TCCGTT 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1388004261,2
    --161614453(+) AAACGA/GAGTTA 2 -- ds50010--------
    rs2004778451,2
    --161614517(+) AATGGA/GGTTAG 2 -- ut310--------
    rs1932150701,2
    C--161614557(+) AAGTCG/TGCTCG 4 A syn10--------

    HapMap Linkage Disequilibrium report for DPM3 (155112367 - 155113071 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DPM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509502CNV Insertion20534489
    dgv3n68CNV Loss17160897
    nsv464084CNV Loss19166990
    dgv132e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): DPM3
    Locus Specific Mutation Databases (LSDB): DPM3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPM3
    DNA2.0 Custom Variant and Variant Library Synthesis for DPM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605951   
    OMIM disorders: 612937  
    UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0
  • Congenital disorder of glycosylation 1O (CDG1O) [MIM:612937]: A multisystem disorder caused by a defect
    in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of
    glycosylation result in a wide variety of clinical features, such as defects in the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. CDG1O patients have increased serum creatine kinase, dystrophic changes on
    muscle biopsy, and reduced O-mannosylation of alpha-dystroglycan. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 1 disease for DPM3:    
    About MalaCards
    congenital disorder of glycosylation, type io

    1 disease from the University of Copenhagen DISEASES database for DPM3:
    Congenital muscular dystrophy

    Find genes that share disorders with DPM3           About GenesLikeMe

    GeneTests: DPM3
    GeneReviews: DPM3
    Genetic Association Database (GAD): DPM3

    Export disorders for DPM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPM3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DPM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PubMed id 10835346)1, 2, 3, 9 Maeda Y.... Kinoshita T. (EMBO J. 2000)
    2. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. (PubMed id 11420690)1, 2 Manos E.J.... Jones D.A. (Oncogene 2001)
    5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies. (PubMed id 19576565)2 Lefeber D.J.... Wevers R.A. (Am. J. Hum. Genet. 2009)
    8. DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. (PubMed id 16280320)1 Ashida H....Kinoshita T. (J. Biol. Chem. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54344 HGNC: 3007 AceView: DPM3 Ensembl:ENSG00000179085 euGenes: HUgn54344
    ECgene: DPM3 Kegg: 54344 H-InvDB: DPM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPM3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=DPM3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPM3 gene:
    Search GeneIP for patents involving DPM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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