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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPM3 Gene

protein-coding   GIFtS: 52
GCID: GC01M155112

dolichyl-phosphate mannosyltransferase polypeptide 3

 Explore 4 diseases affiliated with
DPM3 via our new
 Human Malady Compendium 
Biological research products
for DPM3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dolichyl-Phosphate Mannosyltransferase Polypeptide 31 2     MGC1259041
Dolichol-Phosphate Mannose Synthase Subunit 32 3     MGC1259051
Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 32 3     MGC342751
Mannose-P-Dolichol Synthase Subunit 32 3     Dolichol-Phosphate Mannosyltransferase Subunit 32
DPM Synthase Complex Subunit 32 3     Prostin 12
MPD Synthase Subunit 32 3     Prostin-13
CDG1O2 5     Prostin-13

External Ids:    HGNC: 30071   Entrez Gene: 543442   Ensembl: ENSG000001790857   OMIM: 6059515   UniProtKB: Q9P2X03   

Export aliases for DPM3 gene to outside databases

Previous GC identifers: GC01M152991 GC01M150852 GC01M151887 GC01M152329 GC01M151925 GC01M153379 GC01M126474


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPM3:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic
reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is
synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate
mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts
as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0
Function: Stabilizer subunit of the dolichol-phosphate-mannose synthase complex

Gene Wiki entry for DPM3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPM3 gene promoter:
         Pax-5   Lmo2   STAT3   HNF-4alpha2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

DPM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155112:  view genomic region     (about GC identifiers)

Start:
155,112,367 bp from pter      End:
155,113,071 bp from pter
Size:
705 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0 (See protein sequence)
Recommended Name: Dolichol-phosphate mannosyltransferase subunit 3  
Size: 92 amino acids; 10094 Da
Subunit: Composed of three subunits; DPM1, DPM2 and DPM3. Associated with DPM1 via its C-terminal domain and with DPM2
via its N-terminal portion
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q5SR62 Q5SR63 Q9BXN4 Q9BXN5
Alternative splicing: 2 isoforms:  Q9P2X0-1   Q9P2X0-2   

Explore the universe of human proteins at neXtProt for DPM3: NX_Q9P2X0

DPM3 Protein expression data from MOPED and PaxDb:    About this image 
DPM3 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_061846.2  NP_714963.1  

ENSEMBL proteins: 
 ENSP00000357384   ENSP00000357385   ENSP00000344338  
Reactome Protein details: Q9P2X0
Human Recombinant Protein Products for DPM3: 
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Novus Biologicals DPM3 Lysate
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Uscn Proteins for DPM3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA10835346
GO:0005789endoplasmic reticulum membrane TAS--
GO:0030176integral to endoplasmic reticulum membrane IDA10835346
GO:0031501mannosyltransferase complex TAS16280320
GO:0033185dolichol-phosphate-mannose synthase complex IDA10835346

DPM3 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for DPM3


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DPM3 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR013174 DPM3

Graphical View of Domain Structure for InterPro Entry Q9P2X0

ProtoNet protein and cluster: Q9P2X0

UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0
Similarity: Belongs to the DPM3 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DPM3_HUMAN, Q9P2X0
Function: Stabilizer subunit of the dolichol-phosphate-mannose synthase complex

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004582contributes to dolichyl-phosphate beta-D-mannosyltransferase activity IDA10835346
GO:0005515protein binding IPI10835346
     
DPM3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for DPM3:
 Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DPM3 

miRNA
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Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPM3 (see all 7)
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Gene Editing
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In Situ Assay
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DPM3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein1.00
dolichyl-diphosphooligosaccharide biosynthesis0.33
Synthesis of substrates in N-glycan biosythesis0.53
Synthesis of dolichyl-phosphate mannose0.10
2Asparagine N-linked glycosylation
Asparagine N-linked glycosylation1.00
Post-translational protein modification0.44
N-Glycan biosynthesis0.52
Metabolism of proteins0.15
3Post-translational modification: synthesis of GPI-anchored proteins
Post-translational modification: synthesis of GPI-anchored proteins1.00
4Metabolism
Metabolic pathways0.38

Pathway sources
See GeneCards unified pathways
Show all pathways


1 BioSystems Pathway for DPM3 
    dolichyl-diphosphooligosaccharide biosynthesis

5/7        Reactome Pathways for DPM3 (see all 7)
    Synthesis of substrates in N-glycan biosythesis
Synthesis of dolichyl-phosphate mannose
Asparagine N-linked glycosylation
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins


2         Kegg Pathways  (Kegg details for DPM3):
    N-Glycan biosynthesis
Metabolic pathways


DPM3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPM3

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/15 Interacting proteins for DPM3 (Q9P2X03 ENSP000003573844) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
InteractantInteraction Details
GeneCardExternal ID(s)
DPM1O607623, ENSP000003606444I2D: score=2 STRING: ENSP00000360644
DPM2O947773, ENSP000003221814I2D: score=1 STRING: ENSP00000322181
ALG1ENSP000002623744STRING: ENSP00000262374
ALG3ENSP000003807934STRING: ENSP00000380793
ALG5ENSP000002398914STRING: ENSP00000239891
About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005975carbohydrate metabolic process NAS10835346
GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
GO:0006501C-terminal protein lipidation TAS--
GO:0006506GPI anchor biosynthetic process TAS16280320
GO:0018279protein N-linked glycosylation via asparagine TAS--

DPM3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DPM3
Search CenterWatch for drugs/clinical trials and news about DPM3 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DPM3 gene (2 alternative transcripts): 
NM_018973.3  NM_153741.1  

Unigene Cluster for DPM3:

Dolichyl-phosphate mannosyltransferase polypeptide 3
Hs.110477  [show with all ESTs]
Unigene Representative Sequence: AI557533
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368399(uc001fhm.3) ENST00000368400(uc001fhn.3) ENST00000341298


miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPM3 (see all 7)
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPM3
Sirion Biotech Custom design and validation of potent shRNA sequences against DPM3 
Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPM3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPM3 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 2): DPM3 (NM_153741)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPM3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM3 
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPM3
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPM3

Additional cDNA sequence: 

AB028128.1 AF312922.1 AF312923.1 AK293625.1 BC032223.2 BC065233.1 BC104202.1 BC104203.2 
BC104481.1 BC131546.1 

4 DOTS entries:

DT.100021589  DT.92416857  DT.92416859  DT.95103854 

24/74 AceView cDNA sequences (see all 74):

BC065233 NM_153741 BE222369 AI494306 NM_018973 AI360027 BM665721 AA335870 
CK904114 AI494511 AF312923 BU191858 AA372036 BC032223 F28287 AI870667 
AI339952 AW449563 AI479858 AI309182 AA688208 BE670311 BM021898 AA443873 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DPM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGCGAGGA
DPM3 Expression
About this image
See DPM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPM3

SOURCE GeneReport for Unigene cluster: Hs.110477
    SABiosciences Custom PCR Arrays for DPM3

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPM3
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DPM3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DPM3 gene from 4/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dpm31 , 5 dolichyl-phosphate mannosyltransferase polypeptide more1, 5 85.14(n)1
90.22(a)1
  3 (39.03 cM)5
685631  NM_026767.31  NP_081043.11 
 892593585 
lizard
(Anolis carolinensis)
Reptilia DPM36
--
57(a)
1 ↔ 1
AAWZ02039190(6779-7060)
zebrafish
(Danio rerio)
Actinopterygii dpm31 dolichyl-phosphate mannosyltransferase polypeptide more 57.88(n)
56.04(a)
  393782  NM_200809.2  NP_957103.2 
fruit fly
(Drosophila melanogaster)
Insecta CG339776
--
39(a)
1 ↔ 1
3R(9228281-9228771)


ENSEMBL Gene Tree for DPM3 (if available)
TreeFam Gene Tree for DPM3 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DPM3 gene

DPM3 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for DPM3
PGOHUM00000247259 PGOHUM00000249666


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/46 NCBI SNPs in DPM3 are shown (see all 46    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219081551,2
Cpathogenic155112463(-) CGACTC/TAGCCC 4 S L mis10--------
rs127455761,2
C,F,A,Huntested155113074(+) TTCACA/CTGGCG 2 -- us2k17Minor allele frequency- C:0.01NS EA NA 422
rs49710731,2
C,F,A,Huntested155113104(+) CCAGCG/TCCTCA 2 -- us2k125Minor allele frequency- T:0.46EA NA NS WA 2610
rs1879160631,2
--155112093(+) ACTCCA/GGCCTG 2 -- ds50010--------
rs2016471211,2
C--155112138(-) TACTTC/TTNNNN 2 -- ds50010--------
rs1142655041,2
F--155112338(+) CAATAC/TCCGTT 2 -- ds50011Minor allele frequency- T:0.02WA 118
rs1388004261,2
--155112364(+) AAACGA/GAGTTA 2 -- ds50010--------
rs2004778451,2
--155112428(+) AATGGA/GGTTAG 2 -- ut310--------
rs1932150701,2
C--155112468(+) AAGTCG/TGCTCG 4 A syn10--------
rs1489617151,2
C--155112757(+) GGAGCA/CGAAAG 3 R L mis1 int10--------

HapMap Linkage Disequilibrium report for DPM3 (155112367 - 155113071 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DPM3
     2 CNVs: 3315 4257
Human Gene Mutation Database (HGMD): DPM3

Locus Specific Mutation Databases (LSDB): DPM3

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPM3
DNA2.0 Custom Variant and Variant Library Synthesis for DPM3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DPM3 for disorders           About GeneDecksing

OMIM gene information: 605951   
OMIM disorders: 612937  
UniProtKB/Swiss-Prot: DPM3_HUMAN, Q9P2X0
  • Defects in DPM3 are the cause of congenital disorder of glycosylation type 1O (CDG1O) [MIM:612937]. A
  • multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum
    glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in
    the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and
    immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic
    development, differentiation, and maintenance of cell functions

    4 diseases for DPM3:    About MalaCards
    walker-warburg syndrome    congenital disorder of glycosylation    hypotonia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for DPM3:
    Congenital muscular dystrophy
    GeneTests: DPM3
    Congenital Disorders of Glycosylation


    Export disorders for DPM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPM3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with DPM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PubMed id 10835346)1, 2, 3, 9 Maeda Y.... Kinoshita T. (2000)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. (PubMed id 11420690)1, 2 Manos E.J.... Jones D.A. (2001)
    4. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1 Chambers J.C....Kooner J.S. (2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies. (PubMed id 19576565)2 Lefeber D.J.... Wevers R.A. (2009)
    7. DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. (PubMed id 16280320)1 Ashida H....Kinoshita T. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. (PubMed id 11226175)1 Maeda Y....Kinoshita T. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54344 HGNC: 3007 AceView: DPM3 Ensembl:ENSG00000179085 euGenes: HUgn54344
    ECgene: DPM3 Kegg: 54344 H-InvDB: DPM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPM3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    Patent Information for DPM3 gene:
    Search GeneIP for patents involving DPM3

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