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Aliases for DPM3 Gene

Aliases for DPM3 Gene

  • Dolichyl-Phosphate Mannosyltransferase Polypeptide 3 2 3
  • Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 3 3 4
  • Dolichol-Phosphate Mannose Synthase Subunit 3 3 4
  • Mannose-P-Dolichol Synthase Subunit 3 3 4
  • DPM Synthase Subunit 3 3 4
  • MPD Synthase Subunit 3 3 4
  • Prostin-1 3 4
  • DPM Synthase Complex Subunit 3 3
  • DPM Synthase Complex Subunit 2
  • Prostin 1 3
  • CDG1O 3

External Ids for DPM3 Gene

Previous GeneCards Identifiers for DPM3 Gene

  • GC01M152991
  • GC01M150852
  • GC01M151887
  • GC01M152329
  • GC01M151925
  • GC01M153379
  • GC01M126474

Summaries for DPM3 Gene

Entrez Gene Summary for DPM3 Gene

  • Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPM3 Gene

DPM3 (Dolichyl-Phosphate Mannosyltransferase Polypeptide 3) is a Protein Coding gene. Diseases associated with DPM3 include congenital disorder of glycosylation, type io and muscular dystrophy, congenital. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include dolichyl-phosphate beta-D-mannosyltransferase activity.

UniProtKB/Swiss-Prot for DPM3 Gene

  • Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.

Gene Wiki entry for DPM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPM3 Gene

Genomics for DPM3 Gene

Regulatory Elements for DPM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPM3 Gene

Chromosome:
1
Start:
155,139,891 bp from pter
End:
155,140,595 bp from pter
Size:
705 bases
Orientation:
Minus strand

Genomic View for DPM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPM3 Gene

Proteins for DPM3 Gene

  • Protein details for DPM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2X0-DPM3_HUMAN
    Recommended name:
    Dolichol-phosphate mannosyltransferase subunit 3
    Protein Accession:
    Q9P2X0
    Secondary Accessions:
    • Q5SR62
    • Q5SR63
    • Q9BXN4
    • Q9BXN5

    Protein attributes for DPM3 Gene

    Size:
    92 amino acids
    Molecular mass:
    10094 Da
    Quaternary structure:
    • Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion.

    Alternative splice isoforms for DPM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPM3 Gene

Proteomics data for DPM3 Gene at MOPED

Post-translational modifications for DPM3 Gene

  • Glycosylation at Thr 63
  • Modification sites at PhosphoSitePlus

Other Protein References for DPM3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DPM3

No data available for DME Specific Peptides for DPM3 Gene

Domains & Families for DPM3 Gene

Protein Domains for DPM3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P2X0

UniProtKB/Swiss-Prot:

DPM3_HUMAN :
  • Belongs to the DPM3 family.
Family:
  • Belongs to the DPM3 family.
genes like me logo Genes that share domains with DPM3: view

No data available for Gene Families for DPM3 Gene

Function for DPM3 Gene

Molecular function for DPM3 Gene

UniProtKB/Swiss-Prot Function:
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.

Gene Ontology (GO) - Molecular Function for DPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004582 contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity IDA 10835346
GO:0005515 protein binding IPI 10835346
genes like me logo Genes that share ontologies with DPM3: view
genes like me logo Genes that share phenotypes with DPM3: view

Animal Model Products

miRNA for DPM3 Gene

miRTarBase miRNAs that target DPM3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DPM3 Gene

Localization for DPM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPM3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPM3 Gene COMPARTMENTS Subcellular localization image for DPM3 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for DPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 10835346
GO:0005789 endoplasmic reticulum membrane TAS 16280320
GO:0016020 membrane IDA 19946888
GO:0030176 integral component of endoplasmic reticulum membrane IDA 10835346
GO:0031501 mannosyltransferase complex TAS 16280320
genes like me logo Genes that share ontologies with DPM3: view

Pathways & Interactions for DPM3 Gene

genes like me logo Genes that share pathways with DPM3: view

UniProtKB/Swiss-Prot Q9P2X0-DPM3_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for DPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 10835346
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process TAS 16280320
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with DPM3: view

No data available for SIGNOR curated interactions for DPM3 Gene

Drugs & Compounds for DPM3 Gene

(1) Drugs for DPM3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for DPM3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichol-20
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
2067-66-5
Dolichyl phosphate D-mannose
  • Dolichol phosphate mannose
  • Dolichyl D-mannosyl phosphate
  • Dolichyl phosphate D-mannose
  • DPM
908211-94-9
Guanosine diphosphate mannose
  • GDP Mannose
  • GDP-D-Mannose
  • GDP-Glucose
  • GDP-Mannose
  • Guanosine Diphosphate Mannose
3123-67-9
genes like me logo Genes that share compounds with DPM3: view

Transcripts for DPM3 Gene

mRNA/cDNA for DPM3 Gene

Unigene Clusters for DPM3 Gene

Dolichyl-phosphate mannosyltransferase polypeptide 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPM3 Gene

No ASD Table

Relevant External Links for DPM3 Gene

GeneLoc Exon Structure for
DPM3
ECgene alternative splicing isoforms for
DPM3

Expression for DPM3 Gene

mRNA expression in normal human tissues for DPM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPM3 Gene

This gene is overexpressed in Bone (18.6), Nasal epithelium (13.7), and Adrenal (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPM3 Gene



SOURCE GeneReport for Unigene cluster for DPM3 Gene Hs.110477

genes like me logo Genes that share expression patterns with DPM3: view

Protein tissue co-expression partners for DPM3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPM3 Gene

Orthologs for DPM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPM3 35
  • 89.13 (n)
  • 92.39 (a)
DPM3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPM3 35
  • 90.94 (n)
  • 93.48 (a)
DPM3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpm3 35
  • 85.14 (n)
  • 90.22 (a)
Dpm3 16
Dpm3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPM3 35
  • 99.64 (n)
  • 100 (a)
DPM3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPM3 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPM3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPM3 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dpm3 35
  • 57.88 (n)
  • 56.04 (a)
dpm3 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33977 36
  • 39 (a)
OneToOne
Species with no ortholog for DPM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPM3 Gene

ENSEMBL:
Gene Tree for DPM3 (if available)
TreeFam:
Gene Tree for DPM3 (if available)

Paralogs for DPM3 Gene

Pseudogenes.org Pseudogenes for DPM3 Gene

genes like me logo Genes that share paralogs with DPM3: view

No data available for Paralogs for DPM3 Gene

Variants for DPM3 Gene

Sequence variations from dbSNP and Humsavar for DPM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4971073 untested 155,140,628(+) CCAGC(G/T)CCTCA upstream-variant-2KB
rs6413882 -- 155,142,298(+) atgaa(A/G)cagtg upstream-variant-2KB
rs12126509 -- 155,142,207(+) ttgcc(C/T)aggcg upstream-variant-2KB
rs12745576 untested 155,140,598(+) TTCAC(A/C)TGGCG upstream-variant-2KB
rs34148097 -- 155,141,531(+) AATTT(-/C)ATTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPM3 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850

Variation tolerance for DPM3 Gene

Residual Variation Intolerance Score: 42.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPM3 Gene

HapMap Linkage Disequilibrium report
DPM3
Human Gene Mutation Database (HGMD)
DPM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPM3 Gene

Disorders for DPM3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DPM3 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type io
  • congenital disorder of glycosylation 1o
muscular dystrophy, congenital
  • congenital muscular dystrophy
walker-warburg syndrome
  • cerebroocular dysplasia-muscular dystrophy syndrome
- elite association
Search DPM3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DPM3_HUMAN
  • Congenital disorder of glycosylation 1O (CDG1O) [MIM:612937]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1O patients have increased serum creatine kinase, dystrophic changes on muscle biopsy, and reduced O-mannosylation of alpha-dystroglycan. {ECO:0000269 PubMed:19576565}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DPM3

Genetic Association Database (GAD)
DPM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPM3
genes like me logo Genes that share disorders with DPM3: view

No data available for Genatlas for DPM3 Gene

Publications for DPM3 Gene

  1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PMID: 10835346) Maeda Y. … Kinoshita T. (EMBO J. 2000) 2 23 67
  2. Congenital disorders of glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharides. (PMID: 19862844) Haeuptle M.A. … Hennet T. (Hum. Mutat. 2009) 23 67
  3. A new intronic mutation in the DPM1 gene is associated with a milder form of CDG Ie in two French siblings. (PMID: 16641202) Dancourt J. … Moore S.E. (Pediatr. Res. 2006) 23 67
  4. The divergent 5' ends of DPM2 mRNAs originate from the alternative splicing of two adjacent introns: characterization of the hamster DPM2 gene. (PMID: 14680839) Pu L. … Krag S.S. (Biochem. Biophys. Res. Commun. 2003) 23 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for DPM3 Gene

Sources for DPM3 Gene

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