DPM2 Gene
protein-coding GIFtS: 51
GCID: GC09M130697
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dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory...
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Aliases
for DPM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dolichyl-Phosphate Mannosyltransferase Polypeptide 2, Regulatory Subunit1 2 | | MGC1111931 | | MGC215591 | | CDG1U2 | | Dolichol Phosphate-Mannose Biosynthesis Regulatory Protein2 | | Dolichol Phosphate-Mannose Synthase 22 |
Export aliases for DPM2 gene to outside databasesPrevious GC identifers: GC09U990089 GC09M122343 GC09M124151 GC09M126073 GC09M127776 GC09M129737 GC09M100314 |
Summaries
for DPM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DPM2:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmicreticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man issynthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphatemannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembranedomains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and isrequired for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate toDPM1. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777Function: Regulates the biosynthesis of dolichol phosphate-mannose. Essential for the ER localization and stableexpression of DPM1
Gene Wiki entry for DPM2
|
Genomic Views
for DPM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DPM2 gene promoter:
MEF-2A MEF-2 aMEF-2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DPM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.13 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.13DPM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M130697: view genomic region
(about GC identifiers)
Start:
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130,697,374 bp from pter |
End:
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130,700,763 bp from pter |
Size:
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3,390 bases |
Orientation:
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minus strand |
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Proteins
for DPM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777 (See
protein sequence)Recommended Name: Dolichol phosphate-mannose biosynthesis regulatory protein Size: 84 amino acids; 9312 Da
Subunit: Composed of three subunits; DPM1, DPM2 and DPM3. Interacts with DPM1 and DPM3
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q5XKK9 Q6FGH3Explore the universe of human proteins at neXtProt for DPM2: NX_O94777
DPM2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003854.1
ENSEMBL proteins: ENSP00000322181 ENSP00000362202 Reactome Protein details: O94777
Human Recombinant Protein Products for DPM2:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex |
TAS | 16280320 | | GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0030176 | integral to endoplasmic reticulum membrane |
IEA | -- | | GO:0033185 | dolichol-phosphate-mannose synthase complex |
IDA | 10835346 | | GO:0048471 | perinuclear region of cytoplasm |
IEA | -- |
DPM2 for ontologies About GeneDecksing
DPM2 Antibody Products:
Assay Products for DPM2: |
Protein
Domains /
Families
for DPM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPM2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O94777ProtoNet protein and cluster: O94777 1 Blocks protein family: IPB009914 Dolichol phosphate-mannose biosynthesis regulatory
UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777Similarity: Belongs to the DPM2 family |
Function
for DPM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DPM2_HUMAN, O94777Function: Regulates the biosynthesis of dolichol phosphate-mannose. Essential for the ER localization and stableexpression of DPM1 Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DPM2 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DPM2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPM2 |
|
Pathways & Interactions
for DPM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | | | 2 | Asparagine N-linked glycosylation | | | 3 | Post-translational modification: synthesis of GPI-anchored proteins | | | 4 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for DPM2
5/8 
Reactome Pathways for DPM2 (see all 8)
3 
Kegg Pathways (Kegg details for DPM2):
DPM2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPM2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/25 Interacting proteins for DPM2 (O947773 ENSP000003221814) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic process |
TAS | -- | | GO:0006501 | C-terminal protein lipidation |
TAS | -- | | GO:0006506 | GPI anchor biosynthetic process |
IDA | 10835346 | | GO:0009059 | macromolecule biosynthetic process |
-- | -- | | GO:0016254 | preassembly of GPI anchor in ER membrane |
TAS | -- |
DPM2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DPM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DPM2
Search CenterWatch for drugs/clinical trials and news about DPM2
|
Transcripts
for DPM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DPM2 gene (2 alternative transcripts): NM_003863.3 NM_152690.1 Unigene Cluster for DPM2: Dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit Hs.108973 [show with all ESTs]Unigene Representative Sequence: BC0482565 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495270 ENST00000314392(uc004bsv.2) ENST00000470181 ENST00000473360
ENST00000373110
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DPM2 (NM_003863) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPM2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM2 |
Additional cDNA sequence: AB013361.1 AB451329.1 AB451473.1 AF061729.1 AK312121.1 BC015233.1 BC015374.1 BC048256.2 BC107863.1 CR542134.1 7 DOTS entries: DT.100037217 DT.452527 DT.95335083 DT.100820688 DT.92429740 DT.40121402 DT.100820667 24/291 AceView cDNA sequences (see all 291): AB013361 AI346112 BU558168 BQ448052 AI564059 BX350122 CD671476 BI908184 BM662410 BU077426 BE546235 AI056653 BI758227 AI919385 CR590576 BE543118 BG476139 CB850629 CD674480 AI159842 NM_003863 AI131127 AI954177 BQ012052
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DPM2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
|---|
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| SP1: | | | | | - | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for DPM2
|
Expression
for DPM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGACCTCT
About this image
See DPM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPM2
SOURCE GeneReport for Unigene cluster: Hs.108973
SABiosciences Custom PCR Arrays for DPM2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPM2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPM2 |
Orthologs
for DPM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DPM2 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for DPM2 (if available)
TreeFam Gene Tree for DPM2 (if available) |
Paralogs
for DPM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DPM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DPM2 (130697374 - 130700763 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DPM2: --
Human Gene Mutation Database (HGMD): DPM2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPM2 |
|
Disorders
/ Diseases
for DPM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPM2 for disorders About GeneDecksing
OMIM gene information: 603564
OMIM disorders: --
1  disease for DPM2: About MalaCardscongenital disorder of glycosylation
Export disorders for DPM2 gene to outside databases
|
Publications
for DPM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPM2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with DPM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. (PubMed id 9724629)1, 2, 3 Maeda Y.... Kinoshita T. (1998)
- Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PubMed id 10835346)1, 2, 9 Maeda Y.... Kinoshita T. (2000)
- DPM2-CDG: a muscular dystrophy-dystroglycanopathy synd rome with severe epilepsy. (PubMed id 23109149)1 Barone R....Lefeber D.J. (2012)
- Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (2008)
- DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. (PubMed id 16280320)1 Ashida H....Kinoshita T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)1 Suzuki H....Hayashizaki Y. (2001)
- Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PubMed id 10944123)1 Watanabe R.... Kinoshita T. (2000)
|
External Searches for DPM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DPM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DPM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DPM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DPM2 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ |
|
| | |
About This Section
| Patent Information for DPM2 gene:
Search GeneIP for patents involving DPM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DPM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPM2 |
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