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DPM2 Gene

protein-coding   GIFtS: 51
GCID: GC09M130697

Dolichyl-Phosphate Mannosyltransferase Polypeptide 2, Regulatory...

  See DPM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dolichyl-Phosphate Mannosyltransferase Polypeptide 2, Regulatory
Subunit1 2
DPM Synthase Complex Subunit1 2
Dolichol-Phosphate Mannose Synthase Subunit 22 3
DPM Synthase Subunit 22 3
CDG1U2 5
Dolichol Phosphate-Mannose Biosynthesis Regulatory Protein2

External Ids:    HGNC: 30061   Entrez Gene: 88182   Ensembl: ENSG000001369087   OMIM: 6035645   UniProtKB: O947773   
ORGUL members:         

Export aliases for DPM2 gene to outside databases

Previous GC identifers: GC09U990089 GC09M122343 GC09M124151 GC09M126073 GC09M127776 GC09M129737 GC09M100314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPM2 Gene:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the
endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins.
Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme
dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2
predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein
associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also
enhances the binding of dolichol-phosphate to DPM1. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPM2 Gene:
DPM2 (dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit) is a protein-coding gene. Diseases associated with DPM2 include congenital disorder of glycosylation, type iu, and congenital disorder of glycosylation type i. GO annotations related to this gene include enzyme regulator activity and dolichyl-phosphate beta-D-mannosyltransferase activity.

UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777
Function: Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate
mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated
with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity

Gene Wiki entry for DPM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPM2 gene promoter:
         MEF-2A   MEF-2   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPM2 promoter sequence
   Search Chromatin IP Primers for DPM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

DPM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPM2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130697:  view genomic region     (about GC identifiers)

Start:
130,697,374 bp from pter      End:
130,700,763 bp from pter
Size:
3,390 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777 (See protein sequence)
Recommended Name: Dolichol phosphate-mannose biosynthesis regulatory protein  
Size: 84 amino acids; 9312 Da
Subunit: Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in
the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex
Secondary accessions: Q5XKK9 Q6FGH3

Explore the universe of human proteins at neXtProt for DPM2: NX_O94777

REFSEQ proteins: NP_003854.1  
ENSEMBL proteins: 
 ENSP00000322181   ENSP00000362202  
Reactome Protein details: O94777

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009914 DPM2

Graphical View of Domain Structure for InterPro Entry O94777

ProtoNet protein and cluster: O94777

1 Blocks protein domain: IPB009914 Dolichol phosphate-mannose biosynthesis regulatory

UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777
Similarity: Belongs to the DPM2 family


Find genes that share domains with DPM2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DPM2_HUMAN, O94777
Function: Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate
mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated
with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004582contributes to dolichyl-phosphate beta-D-mannosyltransferase activity IDA10835346
GO:0005515protein binding IPI10835346
GO:0030234enzyme regulator activity IEA--
     
Find genes that share ontologies with DPM2           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DPM2

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DPM2_HUMAN, O94777: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3
mitochondrion2
lysosome1

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex TAS16280320
GO:0005783endoplasmic reticulum ----
GO:0005789endoplasmic reticulum membrane TAS16280320
GO:0030176integral component of endoplasmic reticulum membrane IEA--
GO:0033185dolichol-phosphate-mannose synthase complex IDA10835346

Find genes that share ontologies with DPM2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DPM2 About    
See pathways by source

SuperPathContained pathways About
1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Asparagine N-linked glycosylation0.49
Metabolism of proteins0.30
N-Glycan biosynthesis0.49
dolichyl-diphosphooligosaccharide biosynthesis0.00
Post-translational protein modification0.43
Synthesis of substrates in N-glycan biosythesis0.00
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.38
Synthesis of dolichyl-phosphate mannose0.00
2Post-translational modification- synthesis of GPI-anchored proteins
Post-translational modification- synthesis of GPI-anchored proteins0.76
Synthesis of glycosylphosphatidylinositol (GPI)0.00
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.76
3Metabolism
Metabolic pathways0.38


Find genes that share SuperPaths with DPM2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for DPM2
    dolichyl-diphosphooligosaccharide biosynthesis

2 Reactome Pathways for DPM2
    Synthesis of dolichyl-phosphate mannose
Synthesis of glycosylphosphatidylinositol (GPI)


3 Kegg Pathways  (Kegg details for DPM2):
    N-Glycan biosynthesis
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Metabolic pathways

UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777
Pathway: Protein modification; protein glycosylation

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPM2
Interactions:

    GeneGlobe Interaction Network for DPM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

Selected Interacting proteins for DPM2 (O947773 ENSP000003221814) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000242092P280683, ENSP000003787234I2D: score=1 STRING: ENSP00000378723
ENSG00000226264P280683I2D: score=1 
ENSG00000234154P280683I2D: score=1 
ENSG00000239329P280683I2D: score=1 
ENSG00000241296P280683I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
GO:0006501C-terminal protein lipidation TAS--
GO:0006506GPI anchor biosynthetic process IDA10835346
GO:0009059macromolecule biosynthetic process ----
GO:0016254preassembly of GPI anchor in ER membrane TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for DPM2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DPM2 gene (2 alternative transcripts): 
NM_003863.3  NM_152690.1  

Unigene Cluster for DPM2:

Dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Hs.108973  [show with all ESTs]
Unigene Representative Sequence: BC048256
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000495270 ENST00000314392(uc004bsv.2) ENST00000470181 ENST00000473360
ENST00000373110
miRNA
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1 qRT-PCR Assays for microRNA that regulate DPM2:
hsa-miR-22
SwitchGear 3'UTR luciferase reporter plasmidDPM2 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM2
Primer
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OriGene qPCR primer pairs and template standards for DPM2
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  QuantiTect SYBR Green Assays in human, mouse, rat DPM2
  QuantiFast Probe-based Assays in human, mouse, rat DPM2

Additional mRNA sequence: 

AB013361.1 AB451329.1 AB451473.1 AF061729.1 AK312121.1 BC015233.1 BC015374.1 BC048256.2 
BC107863.1 CR542134.1 

7 DOTS entries:

DT.100037217  DT.452527  DT.95335083  DT.100820688  DT.92429740  DT.40121402  DT.100820667 

Selected AceView cDNA sequences (see all 291):

BQ011843 CK902411 BI761930 BI908184 BQ711320 BU558168 BU188006 BM662410 
AI033586 BU857041 CD674481 CR625100 BE546235 NM_152690 BI835641 BF083168 
AI564059 AI609417 CA307067 BQ009539 AI954177 NM_003863 CB850629 CD674480 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DPM2    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1:              -           -           -               
SP2:                          -           -               
SP3:              -                                       
SP4:                          -                           
SP5:                                      -               


ECgene alternative splicing isoforms for DPM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DPM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTGACCTCT
DPM2 Expression
About this image

DPM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.108973
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DPM2 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dpm21 , 5 dolichol-phosphate (beta-D) mannosyltransferase 21, 5 86.9(n)1
88.1(a)1
  2 (22.09 cM)5
134811  NM_010073.21  NP_034203.11 
 325708585 
chicken
(Gallus gallus)
Aves DPM21 dolichyl-phosphate mannosyltransferase polypeptide more 67.06(n)
65.48(a)
  771539  NM_001199164.1  NP_001186093.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia dpm21 dolichyl-phosphate mannosyltransferase polypeptide more 61.11(n)
58.33(a)
  549051  NM_001016297.2  NP_001016297.1 
zebrafish
(Danio rerio)
Actinopterygii dpm21 dolichol-phosphate (beta-D) mannosyltransferase 2 59.67(n)
60.49(a)
  796295  NM_001122846.1  NP_001116318.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G743401 AT1G74340 60.61(n)
59.74(a)
  843775  NM_106094.6  NP_177574.1 
rice
(Oryza sativa)
Liliopsida Os02g01401011 Os02g0140101 61.84(n)
56.58(a)
  9269261  NM_001185866.1  NP_001172795.1 


ENSEMBL Gene Tree for DPM2 (if available)
TreeFam Gene Tree for DPM2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DPM2 (see all 116)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0697454
Congenital disorder of glycosylation 1U (CDG1U)4--see VAR_0697452 Y C mis40--------
rs48365941,2
C,F,A,H--100318157(+) TTTTGG/TTTTTT 1 -- us2k1 trp37Minor allele frequency- T:0.22NA WA 18
rs113259631,2
C--130701216(+) TTTTT-/TCCCAA 1 -- us2k1 trp32Minor allele frequency- T:0.25NA CSA 4
rs1466194571,2
--130710139(+) TCTGTA/GATGAG 1 -- int10--------
rs1113408371,2
C--130710249(+) GGCACG/AGTGGG 1 -- int11Minor allele frequency- A:0.50CSA 2
rs1402886991,2
C--130710395(+) AACCCA/GGCCAA 1 -- int10--------
rs563952601,2
C,F--130710442(+) GCCTCC/TAATGA 1 -- int11Minor allele frequency- T:0.02NA 120
rs1453015261,2
C--130710512(+) CCAGCA/GCACAG 1 -- int10--------
rs108193211,2
C,F,A,H--130710577(+) AGACCA/GCTCCC 1 -- int122Minor allele frequency- G:0.41NS EA NA WA CSA 2350
rs736693041,2
C,F--130710587(+) CAGCCC/TGCTCC 1 -- int13Minor allele frequency- T:0.04WA EA 240

HapMap Linkage Disequilibrium report for DPM2 (130697374 - 130700763 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for DPM2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6722CNV Insertion18451855
dgv8291n71CNV Loss21882294
nsv893865CNV Loss21882294
nsv466577CNV Loss19166990
dgv8287n71CNV Loss21882294
dgv8293n71CNV Loss21882294
nsv831727CNV Loss17160897
nsv893859CNV Loss21882294
nsv893860CNV Gain21882294

Human Gene Mutation Database (HGMD): DPM2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DPM2
DNA2.0 Custom Variant and Variant Library Synthesis for DPM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603564   
OMIM disorders: 615042  
UniProtKB/Swiss-Prot: DPM2_HUMAN, O94777
  • Congenital disorder of glycosylation 1U (CDG1U) [MIM:615042]: A multisystem disorder caused by a defect
    in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of
    glycosylation result in a wide variety of clinical features, such as defects in the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. Some CDG1U patients have dystrophic changes seen on muscle biopsy and reduced
    O-mannosyl glycans on alpha-dystroglycan. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 3 diseases for DPM2:    
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    congenital disorder of glycosylation, type iu    congenital disorder of glycosylation type i    muscular dystrophy-dystroglycanopathy


    Find genes that share disorders with DPM2           About GenesLikeMe


    Export disorders for DPM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPM2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DPM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. (PubMed id 9724629)1, 2, 3 Maeda Y.... Kinoshita T. (EMBO J. 1998)
    2. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PubMed id 10835346)1, 2, 9 Maeda Y.... Kinoshita T. (EMBO J. 2000)
    3. DPM2-CDG: a muscular dystrophy-dystroglycanopathy syndrome with severe epilepsy. (PubMed id 23109149)1, 2 Barone R....Lefeber D.J. (Ann. Neurol. 2012)
    4. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PubMed id 10944123)1, 2 Watanabe R.... Kinoshita T. (EMBO J. 2000)
    5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
    6. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (Nat. Methods 2008)
    7. DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. (PubMed id 16280320)1 Ashida H....Kinoshita T. (J. Biol. Chem. 2006)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8818 HGNC: 3006 AceView: DPM2 Ensembl:ENSG00000136908 euGenes: HUgn8818
    ECgene: DPM2 Kegg: 8818 H-InvDB: DPM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPM2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=DPM2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPM2 gene:
    Search GeneIP for patents involving DPM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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