DPM1 Gene
protein-coding GIFtS: 63
GCID: GC20M049551
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|
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic...
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Aliases
for DPM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dolichyl-Phosphate Mannosyltransferase Polypeptide 1, Catalytic Subunit1 2 | | DPM Synthase2 3 | | CDGIE1 2 5 | | MPD Synthase2 3 | | MPDS1 2 5 | | EC 2.4.1.833 8 | | Dolichol-Phosphate Mannose Synthase2 3 | | Dolichol Monophosphate Mannose Synthase2 | | Dolichyl-Phosphate Beta-D-Mannosyltransferase2 3 | | Dolichol-Phosphate Mannosyltransferase2 | | Mannose-P-Dolichol Synthase2 3 | | |
Export aliases for DPM1 gene to outside databasesPrevious GC identifers: GC20M049279 GC20M050189 GC20M050236 GC20M048985 GC20M046299 |
Summaries
for DPM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DPM1:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmicreticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man issynthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphatemannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated byDPM2. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DPM1_HUMAN, O60762Function: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man)which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring,and O-mannosylation of proteins
Gene Wiki entry for DPM1
|
Genomic Views
for DPM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DPM1 gene promoter:
Max1 CUTL1 STAT5A C/EBPalpha NRF-2 HOXA5 COMP1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for DPM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.1DPM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M049551: view genomic region
(about GC identifiers)
Start:
|
49,551,404 bp from pter |
End:
|
49,575,092 bp from pter |
Size:
|
23,689 bases |
Orientation:
|
minus strand |
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Proteins
for DPM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPM1_HUMAN, O60762 (See
protein sequence)Recommended Name: Dolichol-phosphate mannosyltransferase Size: 260 amino acids; 29634 Da
Subcellular location: Endoplasmic reticulum
Secondary accessions: O15157 Q6IB78Explore the universe of human proteins at neXtProt for DPM1: NX_O60762
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60762
4/7 DME Specific Peptides for DPM1 (O60762) (see all 7)
DPM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003850.1
ENSEMBL proteins: ENSP00000360644 ENSP00000360638 ENSP00000360640 ENSP00000394921 ENSP00000360639 Reactome Protein details: O60762
Human Recombinant Protein Products for DPM1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DPM1 for ontologies About GeneDecksing
DPM1 Antibody Products:
Assay Products for DPM1: |
Protein
Domains /
Families
for DPM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPM1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60762ProtoNet protein and cluster: O60762 1 Blocks protein family: IPB001173 Glycosyl transferase
UniProtKB/Swiss-Prot: DPM1_HUMAN, O60762Similarity: Belongs to the glycosyltransferase 2 family |
Function
for DPM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DPM1_HUMAN, O60762Function: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man)which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring,and O-mannosylation of proteinsCatalytic activity: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate Enzyme Number (IUBMB): EC 2.4.1.831 2
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
DPM1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for DPM1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPM1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DPM1 (NM_003859) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPM1 |
|
Pathways & Interactions
for DPM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | | | 2 | Asparagine N-linked glycosylation | | | 3 | Post-translational modification: synthesis of GPI-anchored proteins | | | 4 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for DPM1
5/7 
Reactome Pathways for DPM1 (see all 7)
2 
Kegg Pathways (Kegg details for DPM1):
UniProtKB/Swiss-Prot: DPM1_HUMAN, O60762Pathway: Protein modification; protein glycosylation
DPM1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DPM1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/100 Interacting proteins for DPM1 (O607623 ENSP000003606444) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
DPM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DPM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DPM1 for compounds About GeneDecksing
 Browse Tocris compounds for DPM1
5 HMDB Compounds for DPM1 About this table
1 Novoseek chemical compound relationship for DPM1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mannose |
67.1 |
1 |
16284928 (1) |
Search CenterWatch for drugs/clinical trials and news about DPM1
|
Transcripts
for DPM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DPM1 gene: NM_003859.1 Unigene Cluster for DPM1: Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit Hs.654951 [show with all ESTs]Unigene Representative Sequence: BF2177437 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371588(uc002xvw.1) ENST00000466152(uc002xvx.1) ENST00000371582
ENST00000494752 ENST00000371584 ENST00000413082 ENST00000371583
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPM1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DPM1 (NM_003859) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM1 |
Additional cDNA sequence: AF007875.1 AK289569.1 BC007073.1 BC008427.1 BC008466.1 BC016322.1 CR456926.1 D86198.1 19 DOTS entries: DT.100796659 DT.120801461 DT.446160 DT.100796658 DT.95229816 DT.120801483 DT.100796661 DT.120801513 DT.120801535 DT.95229800 DT.95229805 DT.70103349 DT.100765424 DT.120801441 DT.431688 DT.92461445 DT.95229803 DT.120801476 DT.97764499 24/476 AceView cDNA sequences (see all 476): BM457694 BC007073 BC008427 AA295281 BM311079 AI571592 AI917438 CA314774 BG121452 CA442427 CF128068 CR611307 CD641038 BM676390 AA719250 BM713274 CB145704 BM552526 BM971563 BC016322 D86198 T35243 BG285882 BP354868
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DPM1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for DPM1
|
Expression
for DPM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATCTTTTTA
About this image
See DPM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPM1
SOURCE GeneReport for Unigene cluster: Hs.654951
SABiosciences Custom PCR Arrays for DPM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPM1 |
Orthologs
for DPM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for DPM1 gene from 10/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Dpm11 , 5 |
dolichol-phosphate (beta-D) mannosyltransferase 11, 5 |
86.92(n)1
91.15(a)1 |
|
2 (88.46 cM)5
134801 NM_010072.31 NP_034202.11
1682090485 |
chicken
(Gallus gallus) |
Aves |
DPM11 |
dolichyl-phosphate mannosyltransferase polypeptide more |
81.5(n)
91.1(a) |
|
419349 XM_417511.3 XP_417511.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DPM16 |
-- |
82(a) |
1 ↔ 1 |
GL343226.1(2010358-2020898) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.28122 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.26(n) |
|
BX843875.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.129342 |
Transcribed sequence with moderate similarity to protein more |
75.73(n) |
|
CA474488.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG101661 , 3 |
protein amino acid glycosylation
dolichyl-phosphate
more3
CG101661 |
75(a)3
65.68(n)1
75(a)1 |
|
37E53
352401 NM_136136.21 NP_609980.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y66H1A.23
dpm-11 |
dolichol-phosphate mannosyltransferase3
Protein DPM-11 |
64(a)3
64.07(n)1
65.37(a)1 |
|
IV(445577-448335)3
1768741 NM_067530.31 NP_499931.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G205751 |
dolichol-phosphate mannosyltransferase |
61.32(n)
63.79(a) |
|
838646 NM_101908.3 NP_564118.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.74482 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
73.06(n) |
|
AK070153.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
arnC6gtrB6 |
undecaprenyl phosphate-L-Ara4FN transferaseCPS-53 (KpLE1) prophage; bactoprenol glucosyl tran... |
19(a)17(a) |
1 ↔ 1possible ortholog |
Chromosome(2365093-2366061) Chromosome(2466236-2467156) |
ENSEMBL Gene Tree for DPM1 (if available)
TreeFam Gene Tree for DPM1 (if available) |
Paralogs
for DPM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DPM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DPM1 (49551404 - 49575092 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DPM1: --
Human Gene Mutation Database (HGMD): DPM1
Locus Specific Mutation Databases (LSDB): DPM1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPM1 |
|
Disorders
/ Diseases
for DPM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPM1 for disorders About GeneDecksing
OMIM gene information: 603503
OMIM disorders: 608799
UniProtKB/Swiss-Prot: DPM1_HUMAN, O60762
Defects in DPM1 are the cause of congenital disorder of glycosylation type 1E (CDG1E) [MIM:608799]. CDGs aremetabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. Theyare characterized by under-glycosylated serum glycoproteins. CDG1E is an autosomal recessive disorder, characterizedby severe developmental delay, hypotnia, seizures, and dysmorphic features
18  diseases for DPM1: About MalaCardscongenital disorder of glycosylation type 1e congenital disorder of glycosylation recurrent respiratory papillomatosis choanal atresia
hepatic vein thrombosis polycythemia vera bruxism babesiosis
polycythemia thrombocytosis thrombosis myelofibrosis
hepatitis pneumonia tuberculosis malaria
mycobacterium tuberculosis alcoholism
1 disease from the University of Copenhagen DISEASES database for DPM1:Congenital disorder of glycosylation 1 Novoseek disease relationship for DPM1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| congenital disorders |
80 |
2 |
10642597 (1) |
GeneTests: DPM1
Congenital Disorders of Glycosylation
Human Genome Epidemiology (HuGE) Navigator: DPM1 (1 document)
Export disorders for DPM1 gene to outside databases
|
Publications
for DPM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPM1 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with DPM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. (PubMed id 9535917)1, 2, 3, 9 Tomita S.... Kinoshita T. (1998)
- Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe. (PubMed id 9223280)1, 2, 3, 9 Colussi P.A.... Orlean P. (1997)
- Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie). (PubMed id 10642597)1, 2, 9 Kim S.... Freeze H.H. (2000)
- Congenital disorder of glycosylation (CDG) type Ie. A new patient. (PubMed id 15669674)1, 2, 9 Garcia-Silva M.T.... Briones P. (2004)
- Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie. (PubMed id 10642602)1, 2, 9 Imbach T....Hennet T. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PubMed id 10835346)1, 9 Maeda Y.... Kinoshita T. (2000)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for DPM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DPM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DPM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DPM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DPM1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DPM1 | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ |
|
| | |
About This Section
| Patent Information for DPM1 gene:
Search GeneIP for patents involving DPM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DPM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for DPM1 | | OriGene shRNA RFP for DPM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPM1 | | | OriGene Protein Over-expression Lysate for DPM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DPM1 | | OriGene 3'-UTR Clone for DPM1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DPM1 | | OriGene Custom Protein Services for DPM1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPM1 |
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| | | | Search Tocris compounds for DPM1 |
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 | | | DPM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPM1 |
|  |  |  |  | | | | ThermoFisher Antibodies for DPM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPM1 |
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