Aliases for DPH7 Gene
External Ids for DPH7 Gene
Previous HGNC Symbols for DPH7 Gene
Previous GeneCards Identifiers for DPH7 Gene
WDR85 is a WD repeat-containing protein that plays a role in the first step of diphthamide biosynthesis (Carette et al., 2009 [PubMed 19965467]).[supplied by OMIM, Feb 2010]
GeneCards Summary for DPH7 Gene
DPH7 (Diphthamide Biosynthesis 7) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include diphthine methylesterase activity.
UniProtKB/Swiss-Prot for DPH7 Gene
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).