Aliases for DPH7 Gene
External Ids for DPH7 Gene
Previous HGNC Symbols for DPH7 Gene
Previous GeneCards Identifiers for DPH7 Gene
Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]
GeneCards Summary for DPH7 Gene
DPH7 (Diphthamide Biosynthesis 7) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include diphthine methylesterase activity.
UniProtKB/Swiss-Prot for DPH7 Gene
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).