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Aliases for DPH7 Gene

Aliases for DPH7 Gene

  • Diphthamide Biosynthesis 7 2 3
  • WDR85 3 4 6
  • Diphthamide Biosynthesis Protein 7 3 4
  • WD Repeat-Containing Protein 85 3 4
  • WD Repeat Domain 85 2 3
  • C9orf112 3 4
  • Chromosome 9 Open Reading Frame 112 2
  • Diphthine Methyltransferase 3
  • EC 3.1.1.97 4
  • RRT2 3

External Ids for DPH7 Gene

Previous HGNC Symbols for DPH7 Gene

  • C9orf112
  • WDR85

Previous GeneCards Identifiers for DPH7 Gene

  • GC09M140450

Summaries for DPH7 Gene

Entrez Gene Summary for DPH7 Gene

  • WDR85 is a WD repeat-containing protein that plays a role in the first step of diphthamide biosynthesis (Carette et al., 2009 [PubMed 19965467]).[supplied by OMIM, Feb 2010]

GeneCards Summary for DPH7 Gene

DPH7 (Diphthamide Biosynthesis 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DPH7 Gene

  • Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPH7 Gene

Genomics for DPH7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPH7 Gene

Start:
137,554,902 bp from pter
End:
137,578,935 bp from pter
Size:
24,034 bases
Orientation:
Minus strand

Genomic View for DPH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPH7 Gene

No data available for Regulatory Elements for DPH7 Gene

Proteins for DPH7 Gene

  • Protein details for DPH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTV6-DPH7_HUMAN
    Recommended name:
    Diphthine methyltransferase
    Protein Accession:
    Q9BTV6
    Secondary Accessions:
    • Q96AB7

    Protein attributes for DPH7 Gene

    Size:
    452 amino acids
    Molecular mass:
    50575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPH7 Gene

Proteomics data for DPH7 Gene at MOPED

Post-translational modifications for DPH7 Gene

  • Ubiquitination at Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for DPH7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPH7 Gene

Domains for DPH7 Gene

Gene Families for DPH7 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for DPH7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BTV6

UniProtKB/Swiss-Prot:

DPH7_HUMAN :
  • Q9BTV6
Family:
  • Belongs to the DPH7 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DPH7: view

No data available for Suggested Antigen Peptide Sequences for DPH7 Gene

Function for DPH7 Gene

Molecular function for DPH7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Diphthine methyl ester-[translation elongation factor 2] + H(2)O = diphthine-[translation elongation factor 2] + methanol.
UniProtKB/Swiss-Prot Function: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

Enzyme Numbers (IUBMB) for DPH7 Gene

Gene Ontology (GO) - Molecular Function for DPH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0061685 diphthine methylesterase activity IEA --
genes like me logo Genes that share ontologies with DPH7: view

Animal Model Products

CRISPR Products

miRNA for DPH7 Gene

miRTarBase miRNAs that target DPH7

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPH7 Gene

Localization for DPH7 Gene

Gene Ontology (GO) - Cellular Components for DPH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DPH7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for DPH7 Gene

Pathways for DPH7 Gene

SuperPathways for DPH7 Gene

No Data Available

UniProtKB/Swiss-Prot Q9BTV6-DPH7_HUMAN

  • Pathway: Protein modification; peptidyl-diphthamide biosynthesis

Interacting Proteins for DPH7 Gene

Gene Ontology (GO) - Biological Process for DPH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with DPH7: view

No data available for Pathways by source for DPH7 Gene

Transcripts for DPH7 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPH7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPH7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: - - -
SP3:

Relevant External Links for DPH7 Gene

GeneLoc Exon Structure for
DPH7
ECgene alternative splicing isoforms for
DPH7

Expression for DPH7 Gene

mRNA expression in normal human tissues for DPH7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPH7 Gene

genes like me logo Genes that share expressions with DPH7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPH7 Gene

Orthologs for DPH7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH7 36
  • 99 (a)
OneToOne
WDR85 35
  • 91.13 (n)
  • 89.79 (a)
cow
(Bos Taurus)
Mammalia DPH7 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPH7 36
  • 64 (a)
OneToOne
WDR85 35
  • 77.38 (n)
  • 68.31 (a)
mouse
(Mus musculus)
Mammalia Dph7 35
  • 74.51 (n)
  • 68.95 (a)
Dph7 36
  • 62 (a)
OneToOne
Wdr85 16
oppossum
(Monodelphis domestica)
Mammalia DPH7 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPH7 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPH7 36
  • 48 (a)
OneToOne
WDR85 35
  • 60.75 (n)
  • 54.76 (a)
lizard
(Anolis carolinensis)
Reptilia DPH7 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr85 35
  • 57.04 (n)
  • 50.37 (a)
zebrafish
(Danio rerio)
Actinopterygii dph7 35
  • 56.33 (n)
  • 53.61 (a)
dph7 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002839 35
  • 51.8 (n)
  • 42.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3184 35
  • 48.14 (n)
  • 41.53 (a)
CG3184 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y43F4B.9 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRT2 36
  • 26 (a)
OneToOne
RRT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63010 35
  • 46.21 (n)
  • 39.32 (a)
rice
(Oryza sativa)
Liliopsida Os04g0507900 35
  • 51.14 (n)
  • 41.78 (a)
Species with no ortholog for DPH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPH7 Gene

ENSEMBL:
Gene Tree for DPH7 (if available)
TreeFam:
Gene Tree for DPH7 (if available)

Paralogs for DPH7 Gene

Selected SIMAP similar genes for DPH7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPH7: view

No data available for Paralogs for DPH7 Gene

Variants for DPH7 Gene

Sequence variations from dbSNP and Humsavar for DPH7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10110 -- 137,555,130(+) AGTGC(A/C)CAGGC utr-variant-3-prime
rs821314 - 137,574,376(+) GTCCC(C/T)GGCCC missense, reference, utr-variant-5-prime
rs821315 -- 137,576,045(+) AGGTC(C/T)CTTCT intron-variant, utr-variant-5-prime
rs821316 -- 137,576,793(+) gctga(C/T)gcagg intron-variant
rs821319 -- 137,565,330(-) CACCC(A/C)GGGGA intron-variant

Relevant External Links for DPH7 Gene

HapMap Linkage Disequilibrium report
DPH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DPH7 Gene

Disorders for DPH7 Gene

No disorders were found for DPH7 Gene.

No data available for UniProtKB/Swiss-Prot for DPH7 Gene

Publications for DPH7 Gene

  1. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. (PMID: 23486472) Wei H. … Pastan I. (J. Biol. Chem. 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Haploid genetic screens in human cells identify host factors used by pathogens. (PMID: 19965467) Carette J.E. … Brummelkamp T.R. (Science 2009) 3 4

Products for DPH7 Gene

Sources for DPH7 Gene

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