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Aliases for DPH6 Gene

Aliases for DPH6 Gene

  • Diphthamine Biosynthesis 6 2 3
  • ATP-Binding Domain-Containing Protein 4 3 4
  • Diphthine--Ammonia Ligase 2 3
  • Diphthamide Synthetase 3 4
  • ATP Binding Domain 4 2 3
  • Diphthamide Synthase 3 4
  • Protein DPH6 Homolog 3 4
  • ATPBD4 3 4
  • DPH6 Homolog (S. Cerevisiae) 2
  • DPH6 Homolog 3
  • EC 6.3.1.14 4

External Ids for DPH6 Gene

Previous HGNC Symbols for DPH6 Gene

  • ATPBD4

Previous GeneCards Identifiers for DPH6 Gene

  • GC15M035510

Summaries for DPH6 Gene

GeneCards Summary for DPH6 Gene

DPH6 (Diphthamine Biosynthesis 6) is a Protein Coding gene. Among its related pathways are diphthamide biosynthesis. GO annotations related to this gene include diphthine-ammonia ligase activity.

UniProtKB/Swiss-Prot for DPH6 Gene

  • Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPH6 Gene

Genomics for DPH6 Gene

Genomic Location for DPH6 Gene

Start:
35,217,345 bp from pter
End:
35,546,605 bp from pter
Size:
329,261 bases
Orientation:
Minus strand

Genomic View for DPH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPH6 Gene

No data available for Regulatory Elements for DPH6 Gene

Proteins for DPH6 Gene

  • Protein details for DPH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8W6-DPH6_HUMAN
    Recommended name:
    Diphthine--ammonia ligase
    Protein Accession:
    Q7L8W6
    Secondary Accessions:
    • B3KWG1
    • Q96HJ6

    Protein attributes for DPH6 Gene

    Size:
    267 amino acids
    Molecular mass:
    30307 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • When transfected in S.cerevisiae, able to restore diphthamide biosynthesis in a strain lacking DPH6.

    Alternative splice isoforms for DPH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPH6 Gene

Proteomics data for DPH6 Gene at MOPED

Post-translational modifications for DPH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPH6 Gene

No data available for DME Specific Peptides for DPH6 Gene

Domains for DPH6 Gene

Protein Domains for DPH6 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L8W6

UniProtKB/Swiss-Prot:

DPH6_HUMAN :
  • Q7L8W6
Family:
  • Belongs to the Diphthine--ammonia ligase family.
genes like me logo Genes that share domains with DPH6: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for DPH6 Gene

Function for DPH6 Gene

Molecular function for DPH6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + diphthine-[translation elongation factor 2] + NH(3) = AMP + diphosphate + diphthamide-[translation elongation factor 2]
UniProtKB/Swiss-Prot Function: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).

Enzyme Numbers (IUBMB) for DPH6 Gene

Gene Ontology (GO) - Molecular Function for DPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0017178 diphthine-ammonia ligase activity TAS 23169644
genes like me logo Genes that share ontologies with DPH6: view

Phenotypes for DPH6 Gene

GenomeRNAi human phenotypes for DPH6:
genes like me logo Genes that share phenotypes with DPH6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPH6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DPH6 Gene

Localization for DPH6 Gene

Gene Ontology (GO) - Cellular Components for DPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DPH6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for DPH6 Gene

Pathways for DPH6 Gene

SuperPathways for DPH6 Gene

Superpath Contained pathways
1 diphthamide biosynthesis
genes like me logo Genes that share pathways with DPH6: view

Pathways by source for DPH6 Gene

1 BioSystems pathway for DPH6 Gene

UniProtKB/Swiss-Prot Q7L8W6-DPH6_HUMAN

  • Pathway: Protein modification; peptidyl-diphthamide biosynthesis

Interacting Proteins for DPH6 Gene

Gene Ontology (GO) - Biological Process for DPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine TAS 23169644
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with DPH6: view

Transcripts for DPH6 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPH6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPH6 Gene

No ASD Table

Relevant External Links for DPH6 Gene

GeneLoc Exon Structure for
DPH6
ECgene alternative splicing isoforms for
DPH6

Expression for DPH6 Gene

mRNA expression in normal human tissues for DPH6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DPH6 Gene

genes like me logo Genes that share expressions with DPH6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPH6 Gene

Orthologs for DPH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATPBD4 35
  • 99.5 (n)
  • 99.25 (a)
ATPBD4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPH6 35
  • 93.73 (n)
  • 94.36 (a)
DPH6 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPH6 35
  • 93.56 (n)
  • 94.21 (a)
DPH6 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atpbd4 16
Dph6 35
  • 86.09 (n)
  • 87.97 (a)
Dph6 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPH6 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPH6 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dph6 35
  • 86.09 (n)
  • 87.97 (a)
chicken
(Gallus gallus)
Aves ATPBD4 35
  • 79.51 (n)
  • 80 (a)
ATPBD4 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPH6 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dph6 35
  • 70.9 (n)
  • 75.79 (a)
Str.6583 35
zebrafish
(Danio rerio)
Actinopterygii dph6 35
  • 68.27 (n)
  • 72.8 (a)
dph6 36
  • 36 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001943 35
  • 57.18 (n)
  • 63.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1578 35
  • 58.27 (n)
  • 61.38 (a)
CG1578 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01A2.5 35
  • 59.54 (n)
  • 58.87 (a)
E01A2.5 36
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL164W 35
  • 53.47 (n)
  • 50.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 18 (a)
OneToOne
-- 38
DPH6 35
  • 53.65 (n)
  • 52.19 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16984g 35
  • 56.18 (n)
  • 52.11 (a)
corn
(Zea mays)
Liliopsida Zm.17755 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02670 35
  • 48.28 (n)
  • 43.35 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug71 35
  • 58.55 (n)
  • 56.84 (a)
Species with no ortholog for DPH6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPH6 Gene

ENSEMBL:
Gene Tree for DPH6 (if available)
TreeFam:
Gene Tree for DPH6 (if available)

Paralogs for DPH6 Gene

No data available for Paralogs for DPH6 Gene

Variants for DPH6 Gene

Sequence variations from dbSNP and Humsavar for DPH6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs877163 -- 35,394,066(-) GAGAA(A/G)CGTAA intron-variant
rs897322 -- 35,418,575(-) AGTAA(A/G)ATAGA intron-variant
rs958384 -- 35,475,086(-) TACTA(G/T)GTCTG intron-variant
rs970955 -- 35,499,290(-) AAGTT(C/T)TGAAA intron-variant
rs973480 -- 35,500,216(-) TATTT(A/C)CCTGA intron-variant

Relevant External Links for DPH6 Gene

HapMap Linkage Disequilibrium report
DPH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DPH6 Gene

Disorders for DPH6 Gene

No disorders were found for DPH6 Gene.

No data available for UniProtKB/Swiss-Prot for DPH6 Gene

Publications for DPH6 Gene

  1. Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. (PMID: 23169644) Su X. … Lin H. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4
  2. The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network. (PMID: 23468660) Uthman S. … Schaffrath R. (PLoS Genet. 2013) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DPH6 Gene

Sources for DPH6 Gene

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