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Aliases for DPH6 Gene

Aliases for DPH6 Gene

  • Diphthamine Biosynthesis 6 2 3 5
  • ATP-Binding Domain-Containing Protein 4 3 4
  • Diphthamide Synthetase 3 4
  • ATP Binding Domain 4 2 3
  • Diphthamide Synthase 3 4
  • Protein DPH6 Homolog 3 4
  • ATPBD4 3 4
  • DPH6 Homolog (S. Cerevisiae) 2
  • Diphthine--Ammonia Ligase 2
  • DPH6 Homolog 3
  • EC 6.3.1.14 4

External Ids for DPH6 Gene

Previous HGNC Symbols for DPH6 Gene

  • ATPBD4

Previous GeneCards Identifiers for DPH6 Gene

  • GC15M035510

Summaries for DPH6 Gene

GeneCards Summary for DPH6 Gene

DPH6 (Diphthamine Biosynthesis 6) is a Protein Coding gene. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include diphthine-ammonia ligase activity.

UniProtKB/Swiss-Prot for DPH6 Gene

  • Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPH6 Gene

Genomics for DPH6 Gene

Regulatory Elements for DPH6 Gene

Enhancers for DPH6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPH6 on UCSC Golden Path with GeneCards custom track

Promoters for DPH6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPH6 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPH6 Gene

Chromosome:
15
Start:
35,217,345 bp from pter
End:
35,546,222 bp from pter
Size:
328,878 bases
Orientation:
Minus strand

Genomic View for DPH6 Gene

Genes around DPH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPH6 Gene

Proteins for DPH6 Gene

  • Protein details for DPH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8W6-DPH6_HUMAN
    Recommended name:
    Diphthine--ammonia ligase
    Protein Accession:
    Q7L8W6
    Secondary Accessions:
    • B3KWG1
    • Q96HJ6

    Protein attributes for DPH6 Gene

    Size:
    267 amino acids
    Molecular mass:
    30307 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • When transfected in S.cerevisiae, able to restore diphthamide biosynthesis in a strain lacking DPH6.

    Alternative splice isoforms for DPH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPH6 Gene

Proteomics data for DPH6 Gene at MOPED

Post-translational modifications for DPH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPH6 Gene

No data available for DME Specific Peptides for DPH6 Gene

Domains & Families for DPH6 Gene

Protein Domains for DPH6 Gene

Suggested Antigen Peptide Sequences for DPH6 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L8W6

UniProtKB/Swiss-Prot:

DPH6_HUMAN :
  • Belongs to the Diphthine--ammonia ligase family.
Family:
  • Belongs to the Diphthine--ammonia ligase family.
genes like me logo Genes that share domains with DPH6: view

No data available for Gene Families for DPH6 Gene

Function for DPH6 Gene

Molecular function for DPH6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + diphthine-[translation elongation factor 2] + NH(3) = AMP + diphosphate + diphthamide-[translation elongation factor 2].
UniProtKB/Swiss-Prot Function:
Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).

Enzyme Numbers (IUBMB) for DPH6 Gene

genes like me logo Genes that share phenotypes with DPH6: view

Animal Models for DPH6 Gene

MGI Knock Outs for DPH6:
  • Dph6 tm1a(KOMP)Wtsi

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPH6 Gene

Localization for DPH6 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DPH6 Gene

Pathways & Interactions for DPH6 Gene

genes like me logo Genes that share pathways with DPH6: view

UniProtKB/Swiss-Prot Q7L8W6-DPH6_HUMAN

  • Pathway: Protein modification; peptidyl-diphthamide biosynthesis.

Interacting Proteins for DPH6 Gene

Gene Ontology (GO) - Biological Process for DPH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with DPH6: view

No data available for SIGNOR curated interactions for DPH6 Gene

Drugs & Compounds for DPH6 Gene

(2) Drugs for DPH6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Diphthamide Experimental Pharma 0

(4) Additional Compounds for DPH6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Diphthine
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with DPH6: view

Transcripts for DPH6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DPH6 Gene

No ASD Table

Relevant External Links for DPH6 Gene

GeneLoc Exon Structure for
DPH6
ECgene alternative splicing isoforms for
DPH6

Expression for DPH6 Gene

mRNA expression in normal human tissues for DPH6 Gene

Protein differential expression in normal tissues from HIPED for DPH6 Gene

This gene is overexpressed in Heart (42.0), Bone (10.0), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPH6 Gene



genes like me logo Genes that share expression patterns with DPH6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DPH6 Gene

Orthologs for DPH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPH6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPH6 35
  • 93.73 (n)
  • 94.36 (a)
DPH6 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPH6 35
  • 93.56 (n)
  • 94.21 (a)
DPH6 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dph6 35
  • 86.09 (n)
  • 87.97 (a)
Dph6 16
Dph6 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATPBD4 35
  • 99.5 (n)
  • 99.25 (a)
ATPBD4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dph6 35
  • 86.09 (n)
  • 87.97 (a)
oppossum
(Monodelphis domestica)
Mammalia DPH6 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPH6 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATPBD4 35
  • 79.51 (n)
  • 80 (a)
ATPBD4 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPH6 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dph6 35
  • 70.9 (n)
  • 75.79 (a)
Str.6583 35
zebrafish
(Danio rerio)
Actinopterygii dph6 35
  • 68.27 (n)
  • 72.8 (a)
dph6 36
  • 36 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001943 35
  • 57.18 (n)
  • 63.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1578 35
  • 58.27 (n)
  • 61.38 (a)
CG1578 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01A2.5 35
  • 59.54 (n)
  • 58.87 (a)
E01A2.5 36
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL164W 35
  • 53.47 (n)
  • 50.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16984g 35
  • 56.18 (n)
  • 52.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPH6 35
  • 53.65 (n)
  • 52.19 (a)
-- 36
  • 18 (a)
OneToOne
DPH6 38
corn
(Zea mays)
Liliopsida Zm.17755 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02670 35
  • 48.28 (n)
  • 43.35 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug71 35
  • 58.55 (n)
  • 56.84 (a)
Species with no ortholog for DPH6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPH6 Gene

ENSEMBL:
Gene Tree for DPH6 (if available)
TreeFam:
Gene Tree for DPH6 (if available)

Paralogs for DPH6 Gene

No data available for Paralogs for DPH6 Gene

Variants for DPH6 Gene

Sequence variations from dbSNP and Humsavar for DPH6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34907758 - 35,538,464(+) CAGAC(C/G/T)CCACT reference, missense
VAR_031404 -
rs167612 -- 35,310,518(-) TTCAC(A/G)TTCAT intron-variant
rs5022459 -- 35,543,259(+) CACAT(A/T)ATATA intron-variant
rs318335 -- 35,308,478(-) CCCAC(C/T)CCTCA intron-variant

Variation tolerance for DPH6 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DPH6 Gene

Disorders for DPH6 Gene

Relevant External Links for DPH6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPH6

No disorders were found for DPH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPH6 Gene

Publications for DPH6 Gene

  1. Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. (PMID: 23169644) Su X. … Lin H. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4 67
  2. The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network. (PMID: 23468660) Uthman S. … Schaffrath R. (PLoS Genet. 2013) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for DPH6 Gene

Sources for DPH6 Gene

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